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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TTC21A-SALL2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TTC21A-SALL2
FusionPDB ID: 94937
FusionGDB2.0 ID: 94937
HgeneTgene
Gene symbol

TTC21A

SALL2

Gene ID

199223

6297

Gene nametetratricopeptide repeat domain 21Aspalt like transcription factor 2
SynonymsIFT139A|SPGF37|STI2COLB|HSAL2|Sal-2|ZNF795|p150(Sal2)
Cytomap

3p22.2

14q11.2

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 21ATPR domain containing STI2TPR repeat protein 21Astress-inducible protein 2testicular tissue protein Li 212sal-like protein 2zinc finger protein 795zinc finger protein SALL2zinc finger protein Spalt-2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000493856, ENST00000301819, 
ENST00000431162, ENST00000440121, 
ENST00000317492, ENST00000327430, 
ENST00000450879, ENST00000538754, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score1 X 1 X 1=15 X 5 X 3=75
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TTC21A [Title/Abstract] AND SALL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TTC21A(39180277)-SALL2(21993571), # samples:1
Anticipated loss of major functional domain due to fusion event.TTC21A-SALL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TTC21A-SALL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSALL2

GO:0001654

eye development

24412933


check buttonFusion gene breakpoints across TTC21A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SALL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW450316TTC21Achr3

39180277

-SALL2chr14

21993571

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000301819TTC21Achr339180277-ENST00000327430SALL2chr1421993571+85224182344931496
ENST00000301819TTC21Achr339180277-ENST00000317492SALL2chr1421993571+54284182344181471
ENST00000301819TTC21Achr339180277-ENST00000538754SALL2chr1421993571+49894182344181471
ENST00000301819TTC21Achr339180277-ENST00000450879SALL2chr1421993571+69764182344181471
ENST00000431162TTC21Achr339180277-ENST00000327430SALL2chr1421993571+847341336844441458
ENST00000431162TTC21Achr339180277-ENST00000317492SALL2chr1421993571+537941336843691433
ENST00000431162TTC21Achr339180277-ENST00000538754SALL2chr1421993571+494041336843691433
ENST00000431162TTC21Achr339180277-ENST00000450879SALL2chr1421993571+692741336843691433
ENST00000440121TTC21Achr339180277-ENST00000327430SALL2chr1421993571+820538653141761381
ENST00000440121TTC21Achr339180277-ENST00000317492SALL2chr1421993571+511138653141011356
ENST00000440121TTC21Achr339180277-ENST00000538754SALL2chr1421993571+467238653141011356
ENST00000440121TTC21Achr339180277-ENST00000450879SALL2chr1421993571+665938653141011356

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000301819ENST00000327430TTC21Achr339180277-SALL2chr1421993571+0.0037890650.99621093
ENST00000301819ENST00000317492TTC21Achr339180277-SALL2chr1421993571+0.0061547770.99384516
ENST00000301819ENST00000538754TTC21Achr339180277-SALL2chr1421993571+0.0077828670.99221706
ENST00000301819ENST00000450879TTC21Achr339180277-SALL2chr1421993571+0.0087534560.9912465
ENST00000431162ENST00000327430TTC21Achr339180277-SALL2chr1421993571+0.0037804940.9962196
ENST00000431162ENST00000317492TTC21Achr339180277-SALL2chr1421993571+0.0048287020.99517125
ENST00000431162ENST00000538754TTC21Achr339180277-SALL2chr1421993571+0.0062594470.9937405
ENST00000431162ENST00000450879TTC21Achr339180277-SALL2chr1421993571+0.0069212820.99307865
ENST00000440121ENST00000327430TTC21Achr339180277-SALL2chr1421993571+0.0046830810.995317
ENST00000440121ENST00000317492TTC21Achr339180277-SALL2chr1421993571+0.0041770480.9958229
ENST00000440121ENST00000538754TTC21Achr339180277-SALL2chr1421993571+0.0055598740.9944402
ENST00000440121ENST00000450879TTC21Achr339180277-SALL2chr1421993571+0.0060837530.9939162

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>94937_94937_1_TTC21A-SALL2_TTC21A_chr3_39180277_ENST00000301819_SALL2_chr14_21993571_ENST00000317492_length(amino acids)=1471AA_BP=
MFLPLQTLDAPSNRLAARFPRTVTPSTARRDRVPTTLPRESRSAPPHQTRTRSRERPEMSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGL
EKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWL
IGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFMMQQNYSEALEVVNQITVTSGS
FLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKI
IVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLE
FLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSP
LLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDH
PLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENR
ITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVY
DEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLL
LLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQ
LYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVS
SRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKL
LREFYPHSDSSQTQLRLLQGLCRLATREKANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLE
KSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIE
ICNDSWGQGAWTSRSHQPTEVVWRDGKWVSGEGIQKMTHSSPFNQYVAFLSNGLPMKPWNSSSTSTTTPSLAPPVLFGLGTVAGKVPPTM

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>94937_94937_2_TTC21A-SALL2_TTC21A_chr3_39180277_ENST00000301819_SALL2_chr14_21993571_ENST00000327430_length(amino acids)=1496AA_BP=1393
MFLPLQTLDAPSNRLAARFPRTVTPSTARRDRVPTTLPRESRSAPPHQTRTRSRERPEMSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGL
EKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWL
IGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFMMQQNYSEALEVVNQITVTSGS
FLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKI
IVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLE
FLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSP
LLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDH
PLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENR
ITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVY
DEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLL
LLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQ
LYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVS
SRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKL
LREFYPHSDSSQTQLRLLQGLCRLATREKANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLE
KSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIE
ICNDSWGQGAWTSRSHQPTEVVWRDGKWVSGEGIQKMTHSSPFQPPRFWVLRAHGSHLGPREERRGVSRAFPGRCHRYSGWGRRGPDLGQ

--------------------------------------------------------------

>94937_94937_3_TTC21A-SALL2_TTC21A_chr3_39180277_ENST00000301819_SALL2_chr14_21993571_ENST00000450879_length(amino acids)=1471AA_BP=
MFLPLQTLDAPSNRLAARFPRTVTPSTARRDRVPTTLPRESRSAPPHQTRTRSRERPEMSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGL
EKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWL
IGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFMMQQNYSEALEVVNQITVTSGS
FLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKI
IVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLE
FLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSP
LLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDH
PLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENR
ITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVY
DEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLL
LLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQ
LYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVS
SRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKL
LREFYPHSDSSQTQLRLLQGLCRLATREKANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLE
KSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIE
ICNDSWGQGAWTSRSHQPTEVVWRDGKWVSGEGIQKMTHSSPFNQYVAFLSNGLPMKPWNSSSTSTTTPSLAPPVLFGLGTVAGKVPPTM

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>94937_94937_4_TTC21A-SALL2_TTC21A_chr3_39180277_ENST00000301819_SALL2_chr14_21993571_ENST00000538754_length(amino acids)=1471AA_BP=
MFLPLQTLDAPSNRLAARFPRTVTPSTARRDRVPTTLPRESRSAPPHQTRTRSRERPEMSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGL
EKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWL
IGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFMMQQNYSEALEVVNQITVTSGS
FLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKI
IVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLE
FLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSP
LLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDH
PLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENR
ITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVY
DEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLL
LLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQ
LYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVS
SRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKL
LREFYPHSDSSQTQLRLLQGLCRLATREKANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLE
KSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIE
ICNDSWGQGAWTSRSHQPTEVVWRDGKWVSGEGIQKMTHSSPFNQYVAFLSNGLPMKPWNSSSTSTTTPSLAPPVLFGLGTVAGKVPPTM

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>94937_94937_5_TTC21A-SALL2_TTC21A_chr3_39180277_ENST00000431162_SALL2_chr14_21993571_ENST00000317492_length(amino acids)=1433AA_BP=
MPRESRSAPPHQTRTRSRERPEMSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHH
PDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSD
KPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNI
DACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVAT
ELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTAL
LKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSELE
NAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKKEE
GRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEARE
KMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAA
QKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQP
EMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMF
RKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDS
TWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATREKANMEAALG
SFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAY
EYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDSWGQGAWTSRSHQPTEVVWRDGKWVSGEGIQKM

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>94937_94937_6_TTC21A-SALL2_TTC21A_chr3_39180277_ENST00000431162_SALL2_chr14_21993571_ENST00000327430_length(amino acids)=1458AA_BP=1355
MPRESRSAPPHQTRTRSRERPEMSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHH
PDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSD
KPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNI
DACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVAT
ELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTAL
LKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSELE
NAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKKEE
GRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEARE
KMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAA
QKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQP
EMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMF
RKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDS
TWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATREKANMEAALG
SFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAY
EYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDSWGQGAWTSRSHQPTEVVWRDGKWVSGEGIQKM
THSSPQPPRFWVLRAHGSHLGPREERRGVSRAFPGRCHRYSGWGRRGPDLGQSQAGSNPITSRIDPCTPSSSTTPSAPRGRQWPLEYPPD

--------------------------------------------------------------

>94937_94937_7_TTC21A-SALL2_TTC21A_chr3_39180277_ENST00000431162_SALL2_chr14_21993571_ENST00000450879_length(amino acids)=1433AA_BP=
MPRESRSAPPHQTRTRSRERPEMSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHH
PDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSD
KPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNI
DACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVAT
ELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTAL
LKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSELE
NAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKKEE
GRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEARE
KMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAA
QKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQP
EMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMF
RKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDS
TWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATREKANMEAALG
SFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAY
EYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDSWGQGAWTSRSHQPTEVVWRDGKWVSGEGIQKM

--------------------------------------------------------------

>94937_94937_8_TTC21A-SALL2_TTC21A_chr3_39180277_ENST00000431162_SALL2_chr14_21993571_ENST00000538754_length(amino acids)=1433AA_BP=
MPRESRSAPPHQTRTRSRERPEMSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHH
PDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSD
KPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNI
DACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVAT
ELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTAL
LKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSELE
NAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKKEE
GRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEARE
KMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAA
QKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQP
EMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMF
RKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDS
TWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATREKANMEAALG
SFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAY
EYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDSWGQGAWTSRSHQPTEVVWRDGKWVSGEGIQKM

--------------------------------------------------------------

>94937_94937_9_TTC21A-SALL2_TTC21A_chr3_39180277_ENST00000440121_SALL2_chr14_21993571_ENST00000317492_length(amino acids)=1356AA_BP=
MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDVSLCSTMALIYAHKRCEIID
REAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKEYIDRMLKISRGFREAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKM
QLFLARQDWEQTVEMGHRILEKDESNIDACQILTVHELAREGNMTTATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGSHQVILGLV
CSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIF
LQALLMSRKHKGEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVILNPVVKAAP
ALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDY
PEAIKTLKMVIKLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDV
ALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRI
GHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIET
LNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAI
LLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYC
WHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRL
LQGLCRLATREKANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWLLLADIYCQGSKFD
LALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDSWGQGAWTSRSHQ
PTEVVWRDGKWVSGEGIQNQYVAFLSNGLPMKPWNSSSTSTTTPSLAPPVLFGLGTVAGKVPPTMGSREAKEKTAPLLFQPPAPKAVPEK

--------------------------------------------------------------

>94937_94937_10_TTC21A-SALL2_TTC21A_chr3_39180277_ENST00000440121_SALL2_chr14_21993571_ENST00000327430_length(amino acids)=1381AA_BP=1278
MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDVSLCSTMALIYAHKRCEIID
REAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKEYIDRMLKISRGFREAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKM
QLFLARQDWEQTVEMGHRILEKDESNIDACQILTVHELAREGNMTTATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGSHQVILGLV
CSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIF
LQALLMSRKHKGEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVILNPVVKAAP
ALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDY
PEAIKTLKMVIKLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDV
ALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRI
GHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIET
LNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAI
LLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYC
WHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRL
LQGLCRLATREKANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWLLLADIYCQGSKFD
LALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDSWGQGAWTSRSHQ
PTEVVWRDGKWVSGEGIQQPPRFWVLRAHGSHLGPREERRGVSRAFPGRCHRYSGWGRRGPDLGQSQAGSNPITSRIDPCTPSSSTTPSA

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>94937_94937_11_TTC21A-SALL2_TTC21A_chr3_39180277_ENST00000440121_SALL2_chr14_21993571_ENST00000450879_length(amino acids)=1356AA_BP=
MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDVSLCSTMALIYAHKRCEIID
REAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKEYIDRMLKISRGFREAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKM
QLFLARQDWEQTVEMGHRILEKDESNIDACQILTVHELAREGNMTTATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGSHQVILGLV
CSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIF
LQALLMSRKHKGEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVILNPVVKAAP
ALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDY
PEAIKTLKMVIKLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDV
ALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRI
GHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIET
LNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAI
LLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYC
WHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRL
LQGLCRLATREKANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWLLLADIYCQGSKFD
LALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDSWGQGAWTSRSHQ
PTEVVWRDGKWVSGEGIQNQYVAFLSNGLPMKPWNSSSTSTTTPSLAPPVLFGLGTVAGKVPPTMGSREAKEKTAPLLFQPPAPKAVPEK

--------------------------------------------------------------

>94937_94937_12_TTC21A-SALL2_TTC21A_chr3_39180277_ENST00000440121_SALL2_chr14_21993571_ENST00000538754_length(amino acids)=1356AA_BP=
MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDVSLCSTMALIYAHKRCEIID
REAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKEYIDRMLKISRGFREAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKM
QLFLARQDWEQTVEMGHRILEKDESNIDACQILTVHELAREGNMTTATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGSHQVILGLV
CSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIF
LQALLMSRKHKGEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVILNPVVKAAP
ALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDY
PEAIKTLKMVIKLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDV
ALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRI
GHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIET
LNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAI
LLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYC
WHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRL
LQGLCRLATREKANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWLLLADIYCQGSKFD
LALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDSWGQGAWTSRSHQ
PTEVVWRDGKWVSGEGIQNQYVAFLSNGLPMKPWNSSSTSTTTPSLAPPVLFGLGTVAGKVPPTMGSREAKEKTAPLLFQPPAPKAVPEK

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:39180277/chr14:21993571)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSALL2chr3:39180277chr14:21993571ENST0000032743002135_13901008.0Compositional biasNote=Poly-Gly
TgeneSALL2chr3:39180277chr14:21993571ENST0000032743002158_17001008.0Compositional biasNote=Poly-Pro
TgeneSALL2chr3:39180277chr14:21993571ENST0000032743002256_26501008.0Compositional biasNote=Poly-Ser
TgeneSALL2chr3:39180277chr14:21993571ENST0000032743002764_77501008.0Compositional biasNote=Poly-Glu
TgeneSALL2chr3:39180277chr14:21993571ENST0000032743002816_82101008.0Compositional biasNote=Poly-Ala
TgeneSALL2chr3:39180277chr14:21993571ENST0000032743002838_84301008.0Compositional biasNote=Poly-Pro
TgeneSALL2chr3:39180277chr14:21993571ENST000003274300234_5601008.0Zinc fingerC2H2-type 1%3B atypical
TgeneSALL2chr3:39180277chr14:21993571ENST0000032743002373_39501008.0Zinc fingerC2H2-type 2
TgeneSALL2chr3:39180277chr14:21993571ENST0000032743002401_42301008.0Zinc fingerC2H2-type 3
TgeneSALL2chr3:39180277chr14:21993571ENST0000032743002631_65301008.0Zinc fingerC2H2-type 4
TgeneSALL2chr3:39180277chr14:21993571ENST0000032743002659_68101008.0Zinc fingerC2H2-type 5
TgeneSALL2chr3:39180277chr14:21993571ENST0000032743002691_71301008.0Zinc fingerC2H2-type 6
TgeneSALL2chr3:39180277chr14:21993571ENST0000032743002911_93301008.0Zinc fingerC2H2-type 7
TgeneSALL2chr3:39180277chr14:21993571ENST0000032743002940_96301008.0Zinc fingerC2H2-type 8

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-1291028_106101322.0RepeatNote=TPR 16
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129110_14301322.0RepeatNote=TPR 2
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-1291201_123401322.0RepeatNote=TPR 17
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-1291236_126801322.0RepeatNote=TPR 18
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-1291270_130301322.0RepeatNote=TPR 19
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129146_18001322.0RepeatNote=TPR 3
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129181_21301322.0RepeatNote=TPR 4
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129215_24701322.0RepeatNote=TPR 5
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129334_36701322.0RepeatNote=TPR 6
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-1294_3801322.0RepeatNote=TPR 1
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129502_53401322.0RepeatNote=TPR 7
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129572_60501322.0RepeatNote=TPR 8
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129728_76101322.0RepeatNote=TPR 9
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129762_79501322.0RepeatNote=TPR 10
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129797_82801322.0RepeatNote=TPR 11
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129837_86901322.0RepeatNote=TPR 12
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129889_92201322.0RepeatNote=TPR 13
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129924_95601322.0RepeatNote=TPR 14
HgeneTTC21Achr3:39180277chr14:21993571ENST00000301819-129957_99001322.0RepeatNote=TPR 15
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-1291028_106101321.0RepeatNote=TPR 16
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129110_14301321.0RepeatNote=TPR 2
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-1291201_123401321.0RepeatNote=TPR 17
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-1291236_126801321.0RepeatNote=TPR 18
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-1291270_130301321.0RepeatNote=TPR 19
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129146_18001321.0RepeatNote=TPR 3
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129181_21301321.0RepeatNote=TPR 4
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129215_24701321.0RepeatNote=TPR 5
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129334_36701321.0RepeatNote=TPR 6
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-1294_3801321.0RepeatNote=TPR 1
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129502_53401321.0RepeatNote=TPR 7
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129572_60501321.0RepeatNote=TPR 8
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129728_76101321.0RepeatNote=TPR 9
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129762_79501321.0RepeatNote=TPR 10
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129797_82801321.0RepeatNote=TPR 11
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129837_86901321.0RepeatNote=TPR 12
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129889_92201321.0RepeatNote=TPR 13
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129924_95601321.0RepeatNote=TPR 14
HgeneTTC21Achr3:39180277chr14:21993571ENST00000431162-129957_99001321.0RepeatNote=TPR 15
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-1281028_106101273.0RepeatNote=TPR 16
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128110_14301273.0RepeatNote=TPR 2
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-1281201_123401273.0RepeatNote=TPR 17
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-1281236_126801273.0RepeatNote=TPR 18
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-1281270_130301273.0RepeatNote=TPR 19
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128146_18001273.0RepeatNote=TPR 3
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128181_21301273.0RepeatNote=TPR 4
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128215_24701273.0RepeatNote=TPR 5
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128334_36701273.0RepeatNote=TPR 6
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-1284_3801273.0RepeatNote=TPR 1
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128502_53401273.0RepeatNote=TPR 7
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128572_60501273.0RepeatNote=TPR 8
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128728_76101273.0RepeatNote=TPR 9
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128762_79501273.0RepeatNote=TPR 10
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128797_82801273.0RepeatNote=TPR 11
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128837_86901273.0RepeatNote=TPR 12
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128889_92201273.0RepeatNote=TPR 13
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128924_95601273.0RepeatNote=TPR 14
HgeneTTC21Achr3:39180277chr14:21993571ENST00000440121-128957_99001273.0RepeatNote=TPR 15


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TTC21A
SALL2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TTC21A-SALL2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TTC21A-SALL2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource