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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:BCR-ABL1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: BCR-ABL1
	FusionPDB ID: 9501
	FusionGDB2.0 ID: 9501
		Hgene	Tgene
	Gene symbol	BCR	ABL1
	Gene ID	613	25
	Gene name	BCR activator of RhoGEF and GTPase	ABL proto-oncogene 1, non-receptor tyrosine kinase
	Synonyms	ALL\|BCR1\|CML\|D22S11\|D22S662\|PHL	ABL\|BCR-ABL\|CHDSKM\|JTK7\|bcr/abl\|c-ABL\|c-ABL1\|p150\|v-abl
	Cytomap	22q11.23	9q34.12
	Type of gene	protein-coding	protein-coding
	Description	breakpoint cluster region proteinBCR, RhoGEF and GTPase activating proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26	tyrosine-protein kinase ABL1ABL protooncogene 1 nonreceptor tyrosine kinaseAbelson tyrosine-protein kinase 1bcr/c-abl oncogene proteinc-abl oncogene 1, receptor tyrosine kinaseproto-oncogene c-Ablproto-oncogene tyrosine-protein kinase ABL1truncated
	Modification date	20200313	20200327
	UniProtAcc	P11274	P00519
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000436990, ENST00000305877, ENST00000359540, ENST00000398512,	ENST00000318560,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	22 X 142 X 16=49984	21 X 149 X 8=25032
	# samples	163	154
	** MAII score	log2(163/49984*10)=-4.93852248902354 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(154/25032*10)=-4.02277130765866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: BCR [Title/Abstract] AND ABL1 [Title/Abstract] AND fusion [Title/Abstract] Expression of the ABL-BCR Fusion Gene in Philadelphia-Positive Acute Lymphoblastic Leukemia (pmid: 8490164) A Philadelphia-negative chronic myeloid leukemia with a BCR/ABL fusion gene on chromosome 9 (pmid: 9809034)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	BCR(23632600)-ABL1(133729451), # samples:12 ABL1(133589842)-BCR(23634728), # samples:6
Anticipated loss of major functional domain due to fusion event.	BCR-ABL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BCR-ABL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BCR-ABL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BCR-ABL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BCR-ABL1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. BCR-ABL1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. BCR-ABL1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. BCR-ABL1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. BCR-ABL1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. BCR-ABL1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. BCR-ABL1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BCR	GO:0090630	activation of GTPase activity	7479768
Tgene	ABL1	GO:0006974	cellular response to DNA damage stimulus	15657060
Tgene	ABL1	GO:0006975	DNA damage induced protein phosphorylation	18280240
Tgene	ABL1	GO:0018108	peptidyl-tyrosine phosphorylation	7590236\|9144171\|10713049\|11121037
Tgene	ABL1	GO:0038083	peptidyl-tyrosine autophosphorylation	10518561
Tgene	ABL1	GO:0042770	signal transduction in response to DNA damage	9037071\|15657060
Tgene	ABL1	GO:0043065	positive regulation of apoptotic process	9037071
Tgene	ABL1	GO:0046777	protein autophosphorylation	10713049
Tgene	ABL1	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	15657060
Tgene	ABL1	GO:0051353	positive regulation of oxidoreductase activity	12893824
Tgene	ABL1	GO:0051444	negative regulation of ubiquitin-protein transferase activity	20823226
Tgene	ABL1	GO:0070301	cellular response to hydrogen peroxide	10713049
Tgene	ABL1	GO:0071103	DNA conformation change	9558345
Tgene	ABL1	GO:0071901	negative regulation of protein serine/threonine kinase activity	11121037
Tgene	ABL1	GO:1990051	activation of protein kinase C activity	10713049
Tgene	ABL1	GO:2001020	regulation of response to DNA damage stimulus	9461559

Fusion gene breakpoints across BCR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ABL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	biphenotypic leukemia;acute myeloid leukemia;acute lymphoblastic leukemia;lymphoblastic lymphoma;chronic myeloid leukemia	AB069693	BCR	chr22	23615962		ABL1	chr9	133590436
ChimerDB4	LAML	TCGA-AB-2817-03A	BCR	chr22	23524426	-	ABL1	chr9	133729451	+
ChimerDB4	LAML	TCGA-AB-2817-03A	BCR	chr22	23524426	+	ABL1	chr9	133729451	+
ChimerDB4	LAML	TCGA-AB-2817_700GEAAXX_5	BCR	chr22	23524426	+	ABL1	chr9	133729451	+
ChimerDB4	LAML	TCGA-AB-2817_700GFAAXX_5	BCR	chr22	23524426	+	ABL1	chr9	133729451	+
ChimerDB4	LAML	TCGA-AB-2817	BCR	chr22	23524426	+	ABL1	chr9	133729450	+
ChimerDB4	LAML	TCGA-AB-2901-03A	BCR	chr22	23632600	-	ABL1	chr9	133729451	+
ChimerDB4	LAML	TCGA-AB-2901-03A	BCR	chr22	23632600	+	ABL1	chr9	133729451	+
ChimerDB4	LAML	TCGA-AB-2901_61GABAAXX_2	BCR	chr22	23632600	+	ABL1	chr9	133729451	+
ChimerDB4	LAML	TCGA-AB-2901_700FEAAXX_2	BCR	chr22	23632600	+	ABL1	chr9	133729451	+
ChimerDB4	LAML	TCGA-AB-2901	BCR	chr22	23632600	+	ABL1	chr9	133729450	+
ChimerDB4	LAML	TCGA-AB-2941-03A	BCR	chr22	23632600	-	ABL1	chr9	133729451	+
ChimerDB4	LAML	TCGA-AB-2941-03A	BCR	chr22	23632600	+	ABL1	chr9	133729451	+
ChimerDB4	LAML	TCGA-AB-2941_703RKAAXX_5	BCR	chr22	23632600	+	ABL1	chr9	133729451	+
ChimerDB4	LAML	TCGA-AB-2941_70417AAXX_8	BCR	chr22	23632600	+	ABL1	chr9	133729451	+
ChimerDB4	LAML	TCGA-AB-2944-03A	BCR	chr22	23524426	-	ABL1	chr9	133729451	+
ChimerDB4	LAML	TCGA-AB-2944-03A	BCR	chr22	23524426	+	ABL1	chr9	133729451	+
ChimerKB3	.	.	BCR	chr22	23524426	+	ABL1	chr9	133729448	+
ChimerKB3	.	.	BCR	chr22	23524426	+	ABL1	chr9	133729450	+
ChimerKB3	.	.	BCR	chr22	23524426	+	ABL1	chr9	133738147	+
ChimerKB3	.	.	BCR	chr22	23524427	+	ABL1	chr9	133747512	+
ChimerKB3	.	.	BCR	chr22	23524430	+	ABL1	chr9	133730185	+
ChimerKB3	.	.	BCR	chr22	23596172	+	ABL1	chr9	133729537	+
ChimerKB3	.	.	BCR	chr22	23596172	+	ABL1	chr9	133762357	+
ChimerKB3	.	.	BCR	chr22	23603179	+	ABL1	chr9	133729540	+
ChimerKB3	.	.	BCR	chr22	23613779	+	ABL1	chr9	133729451	+
ChimerKB3	.	.	BCR	chr22	23615961	+	ABL1	chr9	133729450	+
ChimerKB3	.	.	BCR	chr22	23631779	+	ABL1	chr9	133729451	+
ChimerKB3	.	.	BCR	chr22	23631808	+	ABL1	chr9	133729449	+
ChimerKB3	.	.	BCR	chr22	23631808	+	ABL1	chr9	133738148	+
ChimerKB3	.	.	BCR	chr22	23631809	+	ABL1	chr9	133747514	+
ChimerKB3	.	.	BCR	chr22	23631811	+	ABL1	chr9	133730186	+
ChimerKB3	.	.	BCR	chr22	23631881	+	ABL1	chr9	133729090	+
ChimerKB3	.	.	BCR	chr22	23632451	+	ABL1	chr9	133615066	+
ChimerKB3	.	.	BCR	chr22	23632600	+	ABL1	chr9	133729450	+
ChimerKB3	.	.	BCR	chr22	23632600	+	ABL1	chr9	133729451	+
ChimerKB3	.	.	BCR	chr22	23632601	+	ABL1	chr9	133747516	+
ChimerKB3	.	.	BCR	chr22	23632602	+	ABL1	chr9	133730188	+
ChimerKB3	.	.	BCR	chr22	23634575	+	ABL1	chr9	133607565	+
ChimerKB3	.	.	BCR	chr22	23654023	+	ABL1	chr9	133729451	+
ChiTaRS5.0	N/A	AB069693	BCR	chr22	23615962	+	ABL1	chr9	133590492	-
ChiTaRS5.0	N/A	AF113911	BCR	chr22	23524426	+	ABL1	chr9	133729448	+
ChiTaRS5.0	N/A	AF192533	BCR	chr22	23634816	+	ABL1	chr9	133729527	+
ChiTaRS5.0	N/A	AF487522	BCR	chr22	23654023	+	ABL1	chr9	133729451	+
ChiTaRS5.0	N/A	AF533988	BCR	chr22	23596172	+	ABL1	chr9	133762357	+
ChiTaRS5.0	N/A	AJ131466	BCR	chr22	23632600	+	ABL1	chr9	133729451	+
ChiTaRS5.0	N/A	AJ131467	BCR	chr22	23631808	+	ABL1	chr9	133729449	+
ChiTaRS5.0	N/A	AM400881	BCR	chr22	23631865	+	ABL1	chr9	133729719	+
ChiTaRS5.0	N/A	AM491359	BCR	chr22	23631811	+	ABL1	chr9	133730186	+
ChiTaRS5.0	N/A	AM491360	BCR	chr22	23632602	+	ABL1	chr9	133730188	+
ChiTaRS5.0	N/A	AM491361	BCR	chr22	23524430	+	ABL1	chr9	133730185	+
ChiTaRS5.0	N/A	AM491362	BCR	chr22	23613779	+	ABL1	chr9	133729451	+
ChiTaRS5.0	N/A	AM491363	BCR	chr22	23654023	+	ABL1	chr9	133729451	+
ChiTaRS5.0	N/A	AM600680	BCR	chr22	23632358	+	ABL1	chr9	133729652	+
ChiTaRS5.0	N/A	AM886138	BCR	chr22	23632056	+	ABL1	chr9	133729676	+
ChiTaRS5.0	N/A	AY043457	BCR	chr22	23631811	+	ABL1	chr9	133730186	+
ChiTaRS5.0	N/A	AY789120	BCR	chr22	23631881	+	ABL1	chr9	133729090	+
ChiTaRS5.0	N/A	DQ898313	BCR	chr22	23524426	+	ABL1	chr9	133738147	+
ChiTaRS5.0	N/A	DQ898314	BCR	chr22	23631808	+	ABL1	chr9	133738148	+
ChiTaRS5.0	N/A	DQ898315	BCR	chr22	23632732	+	ABL1	chr9	133738145	+
ChiTaRS5.0	N/A	DQ912588	BCR	chr22	23524427	+	ABL1	chr9	133747512	+
ChiTaRS5.0	N/A	DQ912589	BCR	chr22	23631809	+	ABL1	chr9	133747514	+
ChiTaRS5.0	N/A	DQ912590	BCR	chr22	23632601	+	ABL1	chr9	133747516	+
ChiTaRS5.0	N/A	EF158045	BCR	chr22	23631808	+	ABL1	chr9	133729449	+
ChiTaRS5.0	N/A	EF423615	BCR	chr22	23631779	+	ABL1	chr9	133729451	+
ChiTaRS5.0	N/A	EU216059	BCR	chr22	23603622	+	ABL1	chr9	133729451	+
ChiTaRS5.0	N/A	EU216060	BCR	chr22	23610619	+	ABL1	chr9	133730198	+
ChiTaRS5.0	N/A	EU216064	BCR	chr22	23603179	+	ABL1	chr9	133729540	+
ChiTaRS5.0	N/A	EU216066	BCR	chr22	23631808	+	ABL1	chr9	133729449	+
ChiTaRS5.0	N/A	EU216070	BCR	chr22	23596172	+	ABL1	chr9	133729537	+
ChiTaRS5.0	N/A	EU216071	BCR	chr22	23632600	+	ABL1	chr9	133729451	+
ChiTaRS5.0	N/A	EU236680	BCR	chr22	23632602	+	ABL1	chr9	133730188	+
ChiTaRS5.0	N/A	EU394716	BCR	chr22	23652600	+	ABL1	chr9	133659336	+
ChiTaRS5.0	N/A	EU394717	BCR	chr22	23615935	+	ABL1	chr9	133729435	+
ChiTaRS5.0	N/A	EU447303	BCR	chr22	23632600	+	ABL1	chr9	133596052	+
ChiTaRS5.0	N/A	FN820207	BCR	chr22	23633144	+	ABL1	chr9	133687480	+
ChiTaRS5.0	N/A	FN820208	BCR	chr22	23632390	+	ABL1	chr9	133660816	+
ChiTaRS5.0	N/A	FN820209	BCR	chr22	23633728	+	ABL1	chr9	133660179	+
ChiTaRS5.0	N/A	FN820210	BCR	chr22	23632277	+	ABL1	chr9	133665067	+
ChiTaRS5.0	N/A	FN820212	BCR	chr22	23634036	+	ABL1	chr9	133662857	+
ChiTaRS5.0	N/A	FN820213	BCR	chr22	23634138	+	ABL1	chr9	133601947	+
ChiTaRS5.0	N/A	FN820215	BCR	chr22	23631916	+	ABL1	chr9	133640514	+
ChiTaRS5.0	N/A	FN820216	BCR	chr22	23633418	+	ABL1	chr9	133627389	+
ChiTaRS5.0	N/A	FN820217	BCR	chr22	23633006	+	ABL1	chr9	133645620	+
ChiTaRS5.0	N/A	FN820218	BCR	chr22	23632754	+	ABL1	chr9	133608657	+
ChiTaRS5.0	N/A	FN820219	BCR	chr22	23632172	+	ABL1	chr9	133620393	+
ChiTaRS5.0	N/A	FN820221	BCR	chr22	23633301	+	ABL1	chr9	133707488	+
ChiTaRS5.0	N/A	FN820222	BCR	chr22	23634541	+	ABL1	chr9	133720348	+
ChiTaRS5.0	N/A	FN820223	BCR	chr22	23631960	+	ABL1	chr9	133594223	+
ChiTaRS5.0	N/A	FN820224	BCR	chr22	23632168	+	ABL1	chr9	133615399	+
ChiTaRS5.0	N/A	FN820225	BCR	chr22	23642964	+	ABL1	chr9	133632531	+
ChiTaRS5.0	N/A	FN820226	BCR	chr22	23632024	+	ABL1	chr9	133718268	+
ChiTaRS5.0	N/A	FN820227	BCR	chr22	23631888	+	ABL1	chr9	133688104	+
ChiTaRS5.0	N/A	FN820228	BCR	chr22	23632404	+	ABL1	chr9	133710298	+
ChiTaRS5.0	N/A	FN820229	BCR	chr22	23632149	+	ABL1	chr9	133659982	+
ChiTaRS5.0	N/A	FN820230	BCR	chr22	23633893	+	ABL1	chr9	133603228	+
ChiTaRS5.0	N/A	FN820231	BCR	chr22	23632055	+	ABL1	chr9	133637694	+
ChiTaRS5.0	N/A	FN820232	BCR	chr22	23632363	+	ABL1	chr9	133628687	+
ChiTaRS5.0	N/A	FN820233	BCR	chr22	23632436	+	ABL1	chr9	133648360	+
ChiTaRS5.0	N/A	FN820235	BCR	chr22	23632085	+	ABL1	chr9	133656686	+
ChiTaRS5.0	N/A	FN820236	BCR	chr22	23631879	+	ABL1	chr9	133704376	+
ChiTaRS5.0	N/A	FN820237	BCR	chr22	23634598	+	ABL1	chr9	133695869	+
ChiTaRS5.0	N/A	FN820238	BCR	chr22	23632000	+	ABL1	chr9	133717558	+
ChiTaRS5.0	N/A	FN820239	BCR	chr22	23632092	+	ABL1	chr9	133669183	+
ChiTaRS5.0	N/A	FN820240	BCR	chr22	23632409	+	ABL1	chr9	133724937	+
ChiTaRS5.0	N/A	FN820242	BCR	chr22	23634657	+	ABL1	chr9	133619936	+
ChiTaRS5.0	N/A	FN820243	BCR	chr22	23632403	+	ABL1	chr9	133620823	+
ChiTaRS5.0	N/A	FN820244	BCR	chr22	23633798	+	ABL1	chr9	133606780	+
ChiTaRS5.0	N/A	FN820245	BCR	chr22	23633141	+	ABL1	chr9	133517392	+
ChiTaRS5.0	N/A	FN820246	BCR	chr22	23631980	+	ABL1	chr9	133605482	+
ChiTaRS5.0	N/A	FN820247	BCR	chr22	23631845	+	ABL1	chr9	133677896	+
ChiTaRS5.0	N/A	FN820248	BCR	chr22	23634778	+	ABL1	chr9	133640908	+
ChiTaRS5.0	N/A	FN820249	BCR	chr22	23632065	+	ABL1	chr9	133630729	+
ChiTaRS5.0	N/A	FN820250	BCR	chr22	23632677	+	ABL1	chr9	133721864	+
ChiTaRS5.0	N/A	FN820251	BCR	chr22	23632328	+	ABL1	chr9	133708513	+
ChiTaRS5.0	N/A	FN820252	BCR	chr22	23633892	+	ABL1	chr9	133711788	+
ChiTaRS5.0	N/A	FN820255	BCR	chr22	23634312	+	ABL1	chr9	133714311	+
ChiTaRS5.0	N/A	FN820257	BCR	chr22	23633633	+	ABL1	chr9	133722745	+
ChiTaRS5.0	N/A	FN820258	BCR	chr22	23633112	+	ABL1	chr9	133681993	+
ChiTaRS5.0	N/A	FN820261	BCR	chr22	23632771	+	ABL1	chr9	133682658	+
ChiTaRS5.0	N/A	FN820262	BCR	chr22	23632831	+	ABL1	chr9	133596999	+
ChiTaRS5.0	N/A	FN820263	BCR	chr22	23632387	+	ABL1	chr9	133610087	+
ChiTaRS5.0	N/A	FN820264	BCR	chr22	23631891	+	ABL1	chr9	133649239	+
ChiTaRS5.0	N/A	FN820266	BCR	chr22	23634622	+	ABL1	chr9	133680092	+
ChiTaRS5.0	N/A	FN820267	BCR	chr22	23631960	+	ABL1	chr9	133591499	+
ChiTaRS5.0	N/A	JQ425238	BCR	chr22	23634575	+	ABL1	chr9	133607565	+
ChiTaRS5.0	N/A	JQ425239	BCR	chr22	23632721	+	ABL1	chr9	133686163	+
ChiTaRS5.0	N/A	JQ425241	BCR	chr22	23633710	+	ABL1	chr9	133674522	+
ChiTaRS5.0	N/A	JQ425244	BCR	chr22	23632564	+	ABL1	chr9	133614220	+
ChiTaRS5.0	N/A	JQ425249	BCR	chr22	23633428	+	ABL1	chr9	133651603	+
ChiTaRS5.0	N/A	JQ425253	BCR	chr22	23632742	+	ABL1	chr9	133607147	+
ChiTaRS5.0	N/A	KR091980	BCR	chr22	23633762	+	ABL1	chr9	133644494	+
ChiTaRS5.0	N/A	KR091981	BCR	chr22	23631907	+	ABL1	chr9	133615409	+
ChiTaRS5.0	N/A	KR091983	BCR	chr22	23634316	+	ABL1	chr9	133656848	+
ChiTaRS5.0	N/A	KR091984	BCR	chr22	23634094	+	ABL1	chr9	133716014	+
ChiTaRS5.0	N/A	KR091985	BCR	chr22	23632972	+	ABL1	chr9	133645075	+
ChiTaRS5.0	N/A	KR091986	BCR	chr22	23634698	+	ABL1	chr9	133618150	+
ChiTaRS5.0	N/A	KR091987	BCR	chr22	23634664	+	ABL1	chr9	133604081	+
ChiTaRS5.0	N/A	KR091988	BCR	chr22	23632035	+	ABL1	chr9	133679658	+
ChiTaRS5.0	N/A	KR091989	BCR	chr22	23633009	+	ABL1	chr9	133634547	+
ChiTaRS5.0	N/A	KR091990	BCR	chr22	23633604	+	ABL1	chr9	133716816	+
ChiTaRS5.0	N/A	KR091991	BCR	chr22	23633295	+	ABL1	chr9	133716070	+
ChiTaRS5.0	N/A	KR091992	BCR	chr22	23633170	+	ABL1	chr9	133517392	+
ChiTaRS5.0	N/A	KR091993	BCR	chr22	23633012	+	ABL1	chr9	133606669	+
ChiTaRS5.0	N/A	KR091994	BCR	chr22	23633568	+	ABL1	chr9	133590657	+
ChiTaRS5.0	N/A	KR091995	BCR	chr22	23634167	+	ABL1	chr9	133650106	+
ChiTaRS5.0	N/A	KR091996	BCR	chr22	23634065	+	ABL1	chr9	133724686	+
ChiTaRS5.0	N/A	KR091997	BCR	chr22	23632492	+	ABL1	chr9	133653642	+
ChiTaRS5.0	N/A	KR091998	BCR	chr22	23633886	+	ABL1	chr9	133726837	+
ChiTaRS5.0	N/A	KR091999	BCR	chr22	23633966	+	ABL1	chr9	133651678	+
ChiTaRS5.0	N/A	KR092000	BCR	chr22	23632628	+	ABL1	chr9	133589802	+
ChiTaRS5.0	N/A	KR092001	BCR	chr22	23632963	+	ABL1	chr9	133658788	+
ChiTaRS5.0	N/A	KR092002	BCR	chr22	23634207	+	ABL1	chr9	133616461	+
ChiTaRS5.0	N/A	KR092003	BCR	chr22	23634207	+	ABL1	chr9	133616461	+
ChiTaRS5.0	N/A	KR092004	BCR	chr22	23634567	+	ABL1	chr9	133598296	+
ChiTaRS5.0	N/A	KR092005	BCR	chr22	23633637	+	ABL1	chr9	133644370	+
ChiTaRS5.0	N/A	KR092006	BCR	chr22	23634681	+	ABL1	chr9	133660338	+
ChiTaRS5.0	N/A	KR092007	BCR	chr22	23632179	+	ABL1	chr9	133629979	+
ChiTaRS5.0	N/A	KR092008	BCR	chr22	23632432	+	ABL1	chr9	133677059	+
ChiTaRS5.0	N/A	KR092009	BCR	chr22	23633071	+	ABL1	chr9	133635337	+
ChiTaRS5.0	N/A	KR092010	BCR	chr22	23633539	+	ABL1	chr9	133601330	+
ChiTaRS5.0	N/A	KR092011	BCR	chr22	23632926	+	ABL1	chr9	133616518	+
ChiTaRS5.0	N/A	KR092012	BCR	chr22	23632255	+	ABL1	chr9	133643802	+
ChiTaRS5.0	N/A	KR092013	BCR	chr22	23634546	+	ABL1	chr9	133722214	+
ChiTaRS5.0	N/A	KR092014	BCR	chr22	23634226	+	ABL1	chr9	133679583	+
ChiTaRS5.0	N/A	KR092015	BCR	chr22	23633667	+	ABL1	chr9	133590447	+
ChiTaRS5.0	N/A	KR092016	BCR	chr22	23633610	+	ABL1	chr9	133644123	+
ChiTaRS5.0	N/A	KR092017	BCR	chr22	23632664	+	ABL1	chr9	133719046	+
ChiTaRS5.0	N/A	KR092018	BCR	chr22	23634603	+	ABL1	chr9	133717382	+
ChiTaRS5.0	N/A	KR092019	BCR	chr22	23633973	+	ABL1	chr9	133696184	+
ChiTaRS5.0	N/A	KR092020	BCR	chr22	23633919	+	ABL1	chr9	133590709	+
ChiTaRS5.0	N/A	KR092022	BCR	chr22	23634507	+	ABL1	chr9	133592438	+
ChiTaRS5.0	N/A	KR092023	BCR	chr22	23633830	+	ABL1	chr9	133662471	+
ChiTaRS5.0	N/A	KR092024	BCR	chr22	23632152	+	ABL1	chr9	133663835	+
ChiTaRS5.0	N/A	KT696168	BCR	chr22	23631808	+	ABL1	chr9	133729449	+
ChiTaRS5.0	N/A	KU234180	BCR	chr22	23615905	+	ABL1	chr9	133710870	+
ChiTaRS5.0	N/A	KU375572	BCR	chr22	23631808	+	ABL1	chr9	133729449	+
ChiTaRS5.0	N/A	KU705509	BCR	chr22	23631808	+	ABL1	chr9	133729449	+
ChiTaRS5.0	N/A	KU705510	BCR	chr22	23631808	+	ABL1	chr9	133729449	+
ChiTaRS5.0	N/A	M13096	BCR	chr22	23632600	+	ABL1	chr9	133729451	+
ChiTaRS5.0	N/A	M17541	BCR	chr22	23524426	+	ABL1	chr9	133729448	+
ChiTaRS5.0	N/A	M19695	BCR	chr22	23632601	+	ABL1	chr9	133655756	+
ChiTaRS5.0	N/A	M19730	BCR	chr22	23524426	+	ABL1	chr9	133729448	+
ChiTaRS5.0	N/A	M25946	BCR	chr22	23632600	+	ABL1	chr9	133729451	+
ChiTaRS5.0	N/A	M31759	BCR	chr22	23633068	+	ABL1	chr9	133697851	+
ChiTaRS5.0	N/A	MH743144	BCR	chr22	23524426	+	ABL1	chr9	133729448	+
ChiTaRS5.0	N/A	S72478	BCR	chr22	23632602	+	ABL1	chr9	133730188	+
ChiTaRS5.0	N/A	S72479	BCR	chr22	23524430	+	ABL1	chr9	133730185	+
ChiTaRS5.0	N/A	U19399	BCR	chr22	23632845	+	ABL1	chr9	133727499	+
ChiTaRS5.0	N/A	U19400	BCR	chr22	23633595	+	ABL1	chr9	133705632	+
ChiTaRS5.0	N/A	U19406	BCR	chr22	23631916	+	ABL1	chr9	133722533	+
ChiTaRS5.0	N/A	U19408	BCR	chr22	23632451	+	ABL1	chr9	133615066	+
ChiTaRS5.0	N/A	X06418	BCR	chr22	23524426	+	ABL1	chr9	133729448	+
ChiTaRS5.0	N/A	X07537	BCR	chr22	23524426	+	ABL1	chr9	133729448	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000305877	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729448	+	7336	2030	751	5343	1530
ENST00000359540	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729448	+	7181	1875	596	5188	1530
ENST00000398512	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729448	+	7181	1875	596	5188	1530
ENST00000305877	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729450	+	7336	2030	751	5343	1530
ENST00000359540	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729450	+	7181	1875	596	5188	1530
ENST00000398512	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729450	+	7181	1875	596	5188	1530
ENST00000305877	BCR	chr22	23524430	+	ENST00000318560	ABL1	chr9	133730185	+	7162	2030	751	5169	1472
ENST00000359540	BCR	chr22	23524430	+	ENST00000318560	ABL1	chr9	133730185	+	7007	1875	596	5014	1472
ENST00000398512	BCR	chr22	23524430	+	ENST00000318560	ABL1	chr9	133730185	+	7007	1875	596	5014	1472
ENST00000305877	BCR	chr22	23613779	+	ENST00000318560	ABL1	chr9	133729451	+	7978	2672	751	5985	1744
ENST00000359540	BCR	chr22	23613779	+	ENST00000318560	ABL1	chr9	133729451	+	7823	2517	596	5830	1744
ENST00000305877	BCR	chr22	23631779	+	ENST00000318560	ABL1	chr9	133729451	+	8688	3382	3363	6695	1110
ENST00000359540	BCR	chr22	23631779	+	ENST00000318560	ABL1	chr9	133729451	+	8533	3227	3208	6540	1110
ENST00000305877	BCR	chr22	23631808	+	ENST00000318560	ABL1	chr9	133729449	+	8764	3458	751	6771	2006
ENST00000359540	BCR	chr22	23631808	+	ENST00000318560	ABL1	chr9	133729449	+	8609	3303	596	6616	2006
ENST00000305877	BCR	chr22	23631811	+	ENST00000318560	ABL1	chr9	133730186	+	8590	3458	751	6597	1948
ENST00000359540	BCR	chr22	23631811	+	ENST00000318560	ABL1	chr9	133730186	+	8435	3303	596	6442	1948
ENST00000305877	BCR	chr22	23632600	+	ENST00000318560	ABL1	chr9	133729450	+	8839	3533	751	6846	2031
ENST00000359540	BCR	chr22	23632600	+	ENST00000318560	ABL1	chr9	133729450	+	8684	3378	596	6691	2031
ENST00000305877	BCR	chr22	23632600	+	ENST00000318560	ABL1	chr9	133729451	+	8839	3533	751	6846	2031
ENST00000359540	BCR	chr22	23632600	+	ENST00000318560	ABL1	chr9	133729451	+	8684	3378	596	6691	2031
ENST00000305877	BCR	chr22	23632602	+	ENST00000318560	ABL1	chr9	133730188	+	8665	3533	751	6672	1973
ENST00000359540	BCR	chr22	23632602	+	ENST00000318560	ABL1	chr9	133730188	+	8510	3378	596	6517	1973
ENST00000305877	BCR	chr22	23654023	+	ENST00000318560	ABL1	chr9	133729451	+	9379	4073	751	7386	2211
ENST00000359540	BCR	chr22	23654023	+	ENST00000318560	ABL1	chr9	133729451	+	9092	3786	596	7099	2167
ENST00000305877	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729451	+	7336	2030	751	5343	1530
ENST00000359540	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729451	+	7181	1875	596	5188	1530
ENST00000398512	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729451	+	7181	1875	596	5188	1530
ENST00000305877	BCR	chr22	23632600	+	ENST00000318560	ABL1	chr9	133729451	+	8839	3533	751	6846	2031
ENST00000359540	BCR	chr22	23632600	+	ENST00000318560	ABL1	chr9	133729451	+	8684	3378	596	6691	2031
ENST00000305877	BCR	chr22	23632600	+	ENST00000318560	ABL1	chr9	133729450	+	8839	3533	751	6846	2031
ENST00000359540	BCR	chr22	23632600	+	ENST00000318560	ABL1	chr9	133729450	+	8684	3378	596	6691	2031
ENST00000305877	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729450	+	7336	2030	751	5343	1530
ENST00000359540	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729450	+	7181	1875	596	5188	1530
ENST00000398512	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729450	+	7181	1875	596	5188	1530
ENST00000305877	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729448	+	7336	2030	751	5343	1530
ENST00000359540	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729448	+	7181	1875	596	5188	1530
ENST00000398512	BCR	chr22	23524426	+	ENST00000318560	ABL1	chr9	133729448	+	7181	1875	596	5188	1530
ENST00000305877	BCR	chr22	23654023	+	ENST00000318560	ABL1	chr9	133729451	+	9379	4073	751	7386	2211
ENST00000359540	BCR	chr22	23654023	+	ENST00000318560	ABL1	chr9	133729451	+	9092	3786	596	7099	2167
ENST00000305877	BCR	chr22	23631808	+	ENST00000318560	ABL1	chr9	133729449	+	8764	3458	751	6771	2006
ENST00000359540	BCR	chr22	23631808	+	ENST00000318560	ABL1	chr9	133729449	+	8609	3303	596	6616	2006
ENST00000305877	BCR	chr22	23631811	+	ENST00000318560	ABL1	chr9	133730186	+	8590	3458	751	6597	1948
ENST00000359540	BCR	chr22	23631811	+	ENST00000318560	ABL1	chr9	133730186	+	8435	3303	596	6442	1948
ENST00000305877	BCR	chr22	23632602	+	ENST00000318560	ABL1	chr9	133730188	+	8665	3533	751	6672	1973
ENST00000359540	BCR	chr22	23632602	+	ENST00000318560	ABL1	chr9	133730188	+	8510	3378	596	6517	1973
ENST00000305877	BCR	chr22	23524430	+	ENST00000318560	ABL1	chr9	133730185	+	7162	2030	751	5169	1472
ENST00000359540	BCR	chr22	23524430	+	ENST00000318560	ABL1	chr9	133730185	+	7007	1875	596	5014	1472
ENST00000398512	BCR	chr22	23524430	+	ENST00000318560	ABL1	chr9	133730185	+	7007	1875	596	5014	1472
ENST00000305877	BCR	chr22	23613779	+	ENST00000318560	ABL1	chr9	133729451	+	7978	2672	751	5985	1744
ENST00000359540	BCR	chr22	23613779	+	ENST00000318560	ABL1	chr9	133729451	+	7823	2517	596	5830	1744
ENST00000305877	BCR	chr22	23631779	+	ENST00000318560	ABL1	chr9	133729451	+	8688	3382	3363	6695	1110
ENST00000359540	BCR	chr22	23631779	+	ENST00000318560	ABL1	chr9	133729451	+	8533	3227	3208	6540	1110
ENST00000305877	BCR	chr22	23615905	+	ENST00000318560	ABL1	chr9	133710870	+	8129	2781	2792	6136	1114
ENST00000359540	BCR	chr22	23615905	+	ENST00000318560	ABL1	chr9	133710870	+	7974	2626	2637	5981	1114

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000305877	ENST00000318560	BCR	chr22	23524426	+	ABL1	chr9	133729451	+	0.004791084	0.9952089
ENST00000359540	ENST00000318560	BCR	chr22	23524426	+	ABL1	chr9	133729451	+	0.004495037	0.99550503
ENST00000398512	ENST00000318560	BCR	chr22	23524426	+	ABL1	chr9	133729451	+	0.004495037	0.99550503
ENST00000305877	ENST00000318560	BCR	chr22	23632600	+	ABL1	chr9	133729451	+	0.007060856	0.9929391
ENST00000359540	ENST00000318560	BCR	chr22	23632600	+	ABL1	chr9	133729451	+	0.006598799	0.9934012
ENST00000305877	ENST00000318560	BCR	chr22	23632600	+	ABL1	chr9	133729450	+	0.007060856	0.9929391
ENST00000359540	ENST00000318560	BCR	chr22	23632600	+	ABL1	chr9	133729450	+	0.006598799	0.9934012
ENST00000305877	ENST00000318560	BCR	chr22	23524426	+	ABL1	chr9	133729450	+	0.004791084	0.9952089
ENST00000359540	ENST00000318560	BCR	chr22	23524426	+	ABL1	chr9	133729450	+	0.004495037	0.99550503
ENST00000398512	ENST00000318560	BCR	chr22	23524426	+	ABL1	chr9	133729450	+	0.004495037	0.99550503
ENST00000305877	ENST00000318560	BCR	chr22	23524426	+	ABL1	chr9	133729448	+	0.004791084	0.9952089
ENST00000359540	ENST00000318560	BCR	chr22	23524426	+	ABL1	chr9	133729448	+	0.004495037	0.99550503
ENST00000398512	ENST00000318560	BCR	chr22	23524426	+	ABL1	chr9	133729448	+	0.004495037	0.99550503
ENST00000305877	ENST00000318560	BCR	chr22	23654023	+	ABL1	chr9	133729451	+	0.006147568	0.9938524
ENST00000359540	ENST00000318560	BCR	chr22	23654023	+	ABL1	chr9	133729451	+	0.005948206	0.99405175
ENST00000305877	ENST00000318560	BCR	chr22	23631808	+	ABL1	chr9	133729449	+	0.007167646	0.9928323
ENST00000359540	ENST00000318560	BCR	chr22	23631808	+	ABL1	chr9	133729449	+	0.006694621	0.9933054
ENST00000305877	ENST00000318560	BCR	chr22	23631811	+	ABL1	chr9	133730186	+	0.0073375	0.99266255
ENST00000359540	ENST00000318560	BCR	chr22	23631811	+	ABL1	chr9	133730186	+	0.006870943	0.99312913
ENST00000305877	ENST00000318560	BCR	chr22	23632602	+	ABL1	chr9	133730188	+	0.007320939	0.9926791
ENST00000359540	ENST00000318560	BCR	chr22	23632602	+	ABL1	chr9	133730188	+	0.006857449	0.9931425
ENST00000305877	ENST00000318560	BCR	chr22	23524430	+	ABL1	chr9	133730185	+	0.004913177	0.99508685
ENST00000359540	ENST00000318560	BCR	chr22	23524430	+	ABL1	chr9	133730185	+	0.004611767	0.99538815
ENST00000398512	ENST00000318560	BCR	chr22	23524430	+	ABL1	chr9	133730185	+	0.004611767	0.99538815
ENST00000305877	ENST00000318560	BCR	chr22	23613779	+	ABL1	chr9	133729451	+	0.005766662	0.9942333
ENST00000359540	ENST00000318560	BCR	chr22	23613779	+	ABL1	chr9	133729451	+	0.005396213	0.9946038
ENST00000305877	ENST00000318560	BCR	chr22	23631779	+	ABL1	chr9	133729451	+	0.05435984	0.94564015
ENST00000359540	ENST00000318560	BCR	chr22	23631779	+	ABL1	chr9	133729451	+	0.052943673	0.9470563
ENST00000305877	ENST00000318560	BCR	chr22	23615905	+	ABL1	chr9	133710870	+	0.04901826	0.95098174
ENST00000359540	ENST00000318560	BCR	chr22	23615905	+	ABL1	chr9	133710870	+	0.047086153	0.9529138

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>9501_9501_1_BCR-ABL1_BCR_chr22_23524426_ENST00000305877_ABL1_chr9_133729448_ENST00000318560_length(amino acids)=1530AA_BP=426
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR

--------------------------------------------------------------

>9501_9501_2_BCR-ABL1_BCR_chr22_23524426_ENST00000305877_ABL1_chr9_133729450_ENST00000318560_length(amino acids)=1530AA_BP=426
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR

--------------------------------------------------------------

>9501_9501_3_BCR-ABL1_BCR_chr22_23524426_ENST00000305877_ABL1_chr9_133729451_ENST00000318560_length(amino acids)=1530AA_BP=426
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR

--------------------------------------------------------------

>9501_9501_4_BCR-ABL1_BCR_chr22_23524426_ENST00000359540_ABL1_chr9_133729448_ENST00000318560_length(amino acids)=1530AA_BP=426
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR

--------------------------------------------------------------

>9501_9501_5_BCR-ABL1_BCR_chr22_23524426_ENST00000359540_ABL1_chr9_133729450_ENST00000318560_length(amino acids)=1530AA_BP=426
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR

--------------------------------------------------------------

>9501_9501_6_BCR-ABL1_BCR_chr22_23524426_ENST00000359540_ABL1_chr9_133729451_ENST00000318560_length(amino acids)=1530AA_BP=426
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR

--------------------------------------------------------------

>9501_9501_7_BCR-ABL1_BCR_chr22_23524426_ENST00000398512_ABL1_chr9_133729448_ENST00000318560_length(amino acids)=1530AA_BP=426
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR

--------------------------------------------------------------

>9501_9501_8_BCR-ABL1_BCR_chr22_23524426_ENST00000398512_ABL1_chr9_133729450_ENST00000318560_length(amino acids)=1530AA_BP=426
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR

--------------------------------------------------------------

>9501_9501_9_BCR-ABL1_BCR_chr22_23524426_ENST00000398512_ABL1_chr9_133729451_ENST00000318560_length(amino acids)=1530AA_BP=426
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR

--------------------------------------------------------------

>9501_9501_10_BCR-ABL1_BCR_chr22_23524430_ENST00000305877_ABL1_chr9_133730185_ENST00000318560_length(amino acids)=1472AA_BP=426
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDAGEKLRVLGYNHNGEWCEAQTKNGQ
GWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAEL
VHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVK
VADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV
YELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGE
SDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAF
TPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPR
DLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPAS
GLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSP
SQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLIST
RVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQ

--------------------------------------------------------------

>9501_9501_11_BCR-ABL1_BCR_chr22_23524430_ENST00000359540_ABL1_chr9_133730185_ENST00000318560_length(amino acids)=1472AA_BP=426
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDAGEKLRVLGYNHNGEWCEAQTKNGQ
GWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAEL
VHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVK
VADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV
YELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGE
SDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAF
TPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPR
DLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPAS
GLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSP
SQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLIST
RVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQ

--------------------------------------------------------------

>9501_9501_12_BCR-ABL1_BCR_chr22_23524430_ENST00000398512_ABL1_chr9_133730185_ENST00000318560_length(amino acids)=1472AA_BP=426
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDAGEKLRVLGYNHNGEWCEAQTKNGQ
GWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAEL
VHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVK
VADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV
YELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGE
SDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAF
TPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPR
DLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPAS
GLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSP
SQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLIST
RVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQ

--------------------------------------------------------------

>9501_9501_13_BCR-ABL1_BCR_chr22_23613779_ENST00000305877_ABL1_chr9_133729451_ENST00000318560_length(amino acids)=1744AA_BP=637
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLEKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKN
GQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLA
ELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKE
AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHL
VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPE
KVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQ
GESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGAL
AFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTL
PRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAP
ASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQ
SPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLI
STRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRE

--------------------------------------------------------------

>9501_9501_14_BCR-ABL1_BCR_chr22_23613779_ENST00000359540_ABL1_chr9_133729451_ENST00000318560_length(amino acids)=1744AA_BP=637
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLEKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKN
GQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLA
ELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKE
AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHL
VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPE
KVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQ
GESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGAL
AFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTL
PRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAP
ASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQ
SPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLI
STRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRE

--------------------------------------------------------------

>9501_9501_15_BCR-ABL1_BCR_chr22_23615905_ENST00000305877_ABL1_chr9_133710870_ENST00000318560_length(amino acids)=1114AA_BP=
MSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKN
GQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLA
ELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKE
AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHL
VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPE
KVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQ
GESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGAL
AFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTL
PRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAP
ASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQ
SPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLI
STRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRE

--------------------------------------------------------------

>9501_9501_16_BCR-ABL1_BCR_chr22_23615905_ENST00000359540_ABL1_chr9_133710870_ENST00000318560_length(amino acids)=1114AA_BP=
MSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKN
GQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLA
ELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKE
AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHL
VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPE
KVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQ
GESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGAL
AFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTL
PRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAP
ASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQ
SPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLI
STRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRE

--------------------------------------------------------------

>9501_9501_17_BCR-ABL1_BCR_chr22_23631779_ENST00000305877_ABL1_chr9_133729451_ENST00000318560_length(amino acids)=1110AA_BP=6
MTINKEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGW
VPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVH
HHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVM
KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVA
DFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYE
LMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESD
PLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTP
LDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDL
QSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGL
PHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQ
EAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRV
SLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQIC

--------------------------------------------------------------

>9501_9501_18_BCR-ABL1_BCR_chr22_23631779_ENST00000359540_ABL1_chr9_133729451_ENST00000318560_length(amino acids)=1110AA_BP=6
MTINKEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGW
VPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVH
HHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVM
KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVA
DFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYE
LMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESD
PLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTP
LDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDL
QSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGL
PHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQ
EAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRV
SLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQIC

--------------------------------------------------------------

>9501_9501_19_BCR-ABL1_BCR_chr22_23631808_ENST00000305877_ABL1_chr9_133729449_ENST00000318560_length(amino acids)=2006AA_BP=902
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKA
TERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
KEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSN
YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHST
VADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK
HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGL
SRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA
CWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDH
EPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTA
DPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTG
RQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKE
EAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAG
EAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRK
TRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATA

--------------------------------------------------------------

>9501_9501_20_BCR-ABL1_BCR_chr22_23631808_ENST00000359540_ABL1_chr9_133729449_ENST00000318560_length(amino acids)=2006AA_BP=902
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKA
TERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
KEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSN
YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHST
VADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK
HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGL
SRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA
CWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDH
EPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTA
DPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTG
RQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKE
EAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAG
EAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRK
TRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATA

--------------------------------------------------------------

>9501_9501_21_BCR-ABL1_BCR_chr22_23631811_ENST00000305877_ABL1_chr9_133730186_ENST00000318560_length(amino acids)=1948AA_BP=902
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKA
TERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
KEGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVY
HYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWK
KYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME
YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG
IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKT
RTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFR
EMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKR
FLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIM
ESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKL
SRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVP
STLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVD

--------------------------------------------------------------

>9501_9501_22_BCR-ABL1_BCR_chr22_23631811_ENST00000359540_ABL1_chr9_133730186_ENST00000318560_length(amino acids)=1948AA_BP=902
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKA
TERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
KEGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVY
HYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWK
KYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME
YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG
IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKT
RTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFR
EMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKR
FLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIM
ESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKL
SRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVP
STLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVD

--------------------------------------------------------------

>9501_9501_23_BCR-ABL1_BCR_chr22_23632600_ENST00000305877_ABL1_chr9_133729450_ENST00000318560_length(amino acids)=2031AA_BP=928
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKA
TERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
KEDDESPGLYGFLNVIVHSATGFKQSSKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLR
VLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA
SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVA
VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNF
IHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY
ELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAA
EHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPE
RRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSA
SCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSS
PPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAP
PPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSAS
SALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRN

--------------------------------------------------------------

>9501_9501_24_BCR-ABL1_BCR_chr22_23632600_ENST00000305877_ABL1_chr9_133729451_ENST00000318560_length(amino acids)=2031AA_BP=928
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKA
TERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
KEDDESPGLYGFLNVIVHSATGFKQSSKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLR
VLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA
SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVA
VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNF
IHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY
ELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAA
EHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPE
RRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSA
SCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSS
PPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAP
PPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSAS
SALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRN

--------------------------------------------------------------

>9501_9501_25_BCR-ABL1_BCR_chr22_23632600_ENST00000359540_ABL1_chr9_133729450_ENST00000318560_length(amino acids)=2031AA_BP=928
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKA
TERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
KEDDESPGLYGFLNVIVHSATGFKQSSKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLR
VLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA
SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVA
VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNF
IHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY
ELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAA
EHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPE
RRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSA
SCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSS
PPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAP
PPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSAS
SALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRN

--------------------------------------------------------------

>9501_9501_26_BCR-ABL1_BCR_chr22_23632600_ENST00000359540_ABL1_chr9_133729451_ENST00000318560_length(amino acids)=2031AA_BP=928
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKA
TERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
KEDDESPGLYGFLNVIVHSATGFKQSSKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLR
VLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA
SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVA
VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNF
IHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY
ELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAA
EHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPE
RRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSA
SCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSS
PPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAP
PPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSAS
SALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRN

--------------------------------------------------------------

>9501_9501_27_BCR-ABL1_BCR_chr22_23632602_ENST00000305877_ABL1_chr9_133730188_ENST00000318560_length(amino acids)=1973AA_BP=926
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKA
TERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
KEDDESPGLYGFLNVIVHSATGFKQSSSEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGING
SFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEM
ERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL
RECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS
IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVE
KELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKT
NLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLW
KKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTR
GTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSK
GPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKK
PVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNS

--------------------------------------------------------------

>9501_9501_28_BCR-ABL1_BCR_chr22_23632602_ENST00000359540_ABL1_chr9_133730188_ENST00000318560_length(amino acids)=1973AA_BP=926
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKA
TERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
KEDDESPGLYGFLNVIVHSATGFKQSSSEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGING
SFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEM
ERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL
RECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS
IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVE
KELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKT
NLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLW
KKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTR
GTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSK
GPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKK
PVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNS

--------------------------------------------------------------

>9501_9501_29_BCR-ABL1_BCR_chr22_23654023_ENST00000305877_ABL1_chr9_133729451_ENST00000318560_length(amino acids)=2211AA_BP=1108
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKA
TERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
KEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKED
GESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIER
RGMEEVGIYRVSGVATDIQALKAAFDVKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLR
VLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA
SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVA
VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNF
IHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY
ELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAA
EHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPE
RRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSA
SCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSS
PPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAP
PPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSAS
SALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRN

--------------------------------------------------------------

>9501_9501_30_BCR-ABL1_BCR_chr22_23654023_ENST00000359540_ABL1_chr9_133729451_ENST00000318560_length(amino acids)=2167AA_BP=1064
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKA
TERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
KEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNELDPQALQDRDWQRTVIAMNGIEVKLSVKFN
SREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVKALQRPVASDFEPQGLS
EAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVS
RNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKP
TVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYI
ITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPI
KWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAF
ETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGG
LNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGAL
RESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALP
RKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTP
TSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNS
DAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVL
DSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:23632600/chr9:133729451)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BCR P11274	ABL1 P00519
FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250\|UniProtKB:Q6PAJ1, ECO:0000269\|PubMed:1657398, ECO:0000269\|PubMed:17116687, ECO:0000269\|PubMed:1903516, ECO:0000269\|PubMed:23940119, ECO:0000269\|PubMed:7479768}.	FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250\|UniProtKB:P00520, ECO:0000269\|PubMed:10391250, ECO:0000269\|PubMed:11971963, ECO:0000269\|PubMed:12379650, ECO:0000269\|PubMed:12531427, ECO:0000269\|PubMed:12672821, ECO:0000269\|PubMed:15031292, ECO:0000269\|PubMed:15556646, ECO:0000269\|PubMed:15657060, ECO:0000269\|PubMed:15886098, ECO:0000269\|PubMed:16424036, ECO:0000269\|PubMed:16678104, ECO:0000269\|PubMed:16943190, ECO:0000269\|PubMed:17306540, ECO:0000269\|PubMed:17623672, ECO:0000269\|PubMed:18328268, ECO:0000269\|PubMed:18945674, ECO:0000269\|PubMed:19891780, ECO:0000269\|PubMed:20357770, ECO:0000269\|PubMed:20417104, ECO:0000269\|PubMed:28428613, ECO:0000269\|PubMed:9037071, ECO:0000269\|PubMed:9144171, ECO:0000269\|PubMed:9461559}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000305877

824_827

902.3333333333334

1272.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000359540

824_827

902.3333333333334

1228.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000305877

824_827

902.3333333333334

1272.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000359540

824_827

902.3333333333334

1228.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000305877

824_827

927.3333333333334

1272.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000359540

824_827

927.3333333333334

1228.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000305877

824_827

927.3333333333334

1272.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000359540

824_827

927.3333333333334

1228.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000305877

824_827

927.3333333333334

1272.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000359540

824_827

927.3333333333334

1228.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000305877

824_827

1107.3333333333333

1272.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000359540

824_827

1063.3333333333333

1228.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000305877

498_691

902.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000305877

708_866

902.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000359540

498_691

902.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000359540

708_866

902.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000305877

498_691

902.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000305877

708_866

902.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000359540

498_691

902.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000359540

708_866

902.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000305877

498_691

927.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000305877

708_866

927.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000359540

498_691

927.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000359540

708_866

927.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000305877

498_691

927.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000305877

708_866

927.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000359540

498_691

927.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000359540

708_866

927.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000305877

498_691

927.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000305877

708_866

927.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000359540

498_691

927.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000359540

708_866

927.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000305877

498_691

1107.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000305877

708_866

1107.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000305877

893_1020

1107.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000359540

498_691

1063.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000359540

708_866

1063.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000359540

893_1020

1063.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000305877

197_385

426.3333333333333

1272.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000305877

1_426

426.3333333333333

1272.0

Region

Note=Kinase

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000359540

197_385

426.3333333333333

1228.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000359540

1_426

426.3333333333333

1228.0

Region

Note=Kinase

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000305877

197_385

426.3333333333333

1272.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000305877

1_426

426.3333333333333

1272.0

Region

Note=Kinase

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000359540

197_385

426.3333333333333

1228.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000359540

1_426

426.3333333333333

1228.0

Region

Note=Kinase

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000305877

197_385

426.3333333333333

1272.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000305877

1_426

426.3333333333333

1272.0

Region

Note=Kinase

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000359540

197_385

426.3333333333333

1228.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000359540

1_426

426.3333333333333

1228.0

Region

Note=Kinase

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000305877

197_385

426.3333333333333

1272.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000305877

1_426

426.3333333333333

1272.0

Region

Note=Kinase

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000359540

197_385

426.3333333333333

1228.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000359540

1_426

426.3333333333333

1228.0

Region

Note=Kinase

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000305877

197_385

640.3333333333334

1272.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000305877

1_426

640.3333333333334

1272.0

Region

Note=Kinase

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000359540

197_385

640.3333333333334

1228.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000359540

1_426

640.3333333333334

1228.0

Region

Note=Kinase

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000305877

197_385

902.3333333333334

1272.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000305877

1_426

902.3333333333334

1272.0

Region

Note=Kinase

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000359540

197_385

902.3333333333334

1228.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000359540

1_426

902.3333333333334

1228.0

Region

Note=Kinase

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000305877

197_385

902.3333333333334

1272.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000305877

1_426

902.3333333333334

1272.0

Region

Note=Kinase

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000359540

197_385

902.3333333333334

1228.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000359540

1_426

902.3333333333334

1228.0

Region

Note=Kinase

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000305877

197_385

927.3333333333334

1272.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000305877

1_426

927.3333333333334

1272.0

Region

Note=Kinase

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000359540

197_385

927.3333333333334

1228.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000359540

1_426

927.3333333333334

1228.0

Region

Note=Kinase

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000305877

197_385

927.3333333333334

1272.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000305877

1_426

927.3333333333334

1272.0

Region

Note=Kinase

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000359540

197_385

927.3333333333334

1228.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000359540

1_426

927.3333333333334

1228.0

Region

Note=Kinase

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000305877

197_385

927.3333333333334

1272.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000305877

1_426

927.3333333333334

1272.0

Region

Note=Kinase

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000359540

197_385

927.3333333333334

1228.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000359540

1_426

927.3333333333334

1228.0

Region

Note=Kinase

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000305877

197_385

1107.3333333333333

1272.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000305877

1_426

1107.3333333333333

1272.0

Region

Note=Kinase

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000359540

197_385

1063.3333333333333

1228.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000359540

1_426

1063.3333333333333

1228.0

Region

Note=Kinase

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

605_609

26.333333333333332

1131.0

Compositional bias

Note=Poly-Lys

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

782_1019

26.333333333333332

1131.0

Compositional bias

Note=Pro-rich

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

897_903

26.333333333333332

1131.0

Compositional bias

Note=Poly-Pro

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

605_609

26.333333333333332

1131.0

Compositional bias

Note=Poly-Lys

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

782_1019

26.333333333333332

1131.0

Compositional bias

Note=Pro-rich

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

897_903

26.333333333333332

1131.0

Compositional bias

Note=Poly-Pro

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

605_609

26.333333333333332

1131.0

Compositional bias

Note=Poly-Lys

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

782_1019

26.333333333333332

1131.0

Compositional bias

Note=Pro-rich

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

897_903

26.333333333333332

1131.0

Compositional bias

Note=Poly-Pro

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

605_609

84.33333333333333

1131.0

Compositional bias

Note=Poly-Lys

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

782_1019

84.33333333333333

1131.0

Compositional bias

Note=Pro-rich

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

897_903

84.33333333333333

1131.0

Compositional bias

Note=Poly-Pro

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

605_609

26.333333333333332

1131.0

Compositional bias

Note=Poly-Lys

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

782_1019

26.333333333333332

1131.0

Compositional bias

Note=Pro-rich

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

897_903

26.333333333333332

1131.0

Compositional bias

Note=Poly-Pro

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

18_22

1131.0

Compositional bias

Note=Poly-Ser

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

605_609

1131.0

Compositional bias

Note=Poly-Lys

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

782_1019

1131.0

Compositional bias

Note=Pro-rich

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

897_903

1131.0

Compositional bias

Note=Poly-Pro

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

605_609

26.333333333333332

1131.0

Compositional bias

Note=Poly-Lys

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

782_1019

26.333333333333332

1131.0

Compositional bias

Note=Pro-rich

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

897_903

26.333333333333332

1131.0

Compositional bias

Note=Poly-Pro

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

605_609

26.333333333333332

1131.0

Compositional bias

Note=Poly-Lys

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

782_1019

26.333333333333332

1131.0

Compositional bias

Note=Pro-rich

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

897_903

26.333333333333332

1131.0

Compositional bias

Note=Poly-Pro

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

605_609

84.33333333333333

1131.0

Compositional bias

Note=Poly-Lys

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

782_1019

84.33333333333333

1131.0

Compositional bias

Note=Pro-rich

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

897_903

84.33333333333333

1131.0

Compositional bias

Note=Poly-Pro

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

605_609

26.333333333333332

1131.0

Compositional bias

Note=Poly-Lys

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

782_1019

26.333333333333332

1131.0

Compositional bias

Note=Pro-rich

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

897_903

26.333333333333332

1131.0

Compositional bias

Note=Poly-Pro

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

605_609

26.333333333333332

1131.0

Compositional bias

Note=Poly-Lys

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

782_1019

26.333333333333332

1131.0

Compositional bias

Note=Pro-rich

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

897_903

26.333333333333332

1131.0

Compositional bias

Note=Poly-Pro

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

605_609

84.33333333333333

1131.0

Compositional bias

Note=Poly-Lys

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

782_1019

84.33333333333333

1131.0

Compositional bias

Note=Pro-rich

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

897_903

84.33333333333333

1131.0

Compositional bias

Note=Poly-Pro

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

605_609

26.333333333333332

1131.0

Compositional bias

Note=Poly-Lys

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

782_1019

26.333333333333332

1131.0

Compositional bias

Note=Pro-rich

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

897_903

26.333333333333332

1131.0

Compositional bias

Note=Poly-Pro

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

127_217

26.333333333333332

1131.0

Domain

SH2

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

242_493

26.333333333333332

1131.0

Domain

Protein kinase

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

61_121

26.333333333333332

1131.0

Domain

SH3

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

127_217

26.333333333333332

1131.0

Domain

SH2

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

242_493

26.333333333333332

1131.0

Domain

Protein kinase

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

61_121

26.333333333333332

1131.0

Domain

SH3

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

127_217

26.333333333333332

1131.0

Domain

SH2

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

242_493

26.333333333333332

1131.0

Domain

Protein kinase

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

61_121

26.333333333333332

1131.0

Domain

SH3

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

127_217

84.33333333333333

1131.0

Domain

SH2

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

242_493

84.33333333333333

1131.0

Domain

Protein kinase

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

127_217

26.333333333333332

1131.0

Domain

SH2

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

242_493

26.333333333333332

1131.0

Domain

Protein kinase

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

61_121

26.333333333333332

1131.0

Domain

SH3

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

127_217

1131.0

Domain

SH2

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

242_493

1131.0

Domain

Protein kinase

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

61_121

1131.0

Domain

SH3

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

127_217

26.333333333333332

1131.0

Domain

SH2

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

242_493

26.333333333333332

1131.0

Domain

Protein kinase

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

61_121

26.333333333333332

1131.0

Domain

SH3

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

127_217

26.333333333333332

1131.0

Domain

SH2

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

242_493

26.333333333333332

1131.0

Domain

Protein kinase

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

61_121

26.333333333333332

1131.0

Domain

SH3

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

127_217

84.33333333333333

1131.0

Domain

SH2

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

242_493

84.33333333333333

1131.0

Domain

Protein kinase

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

127_217

26.333333333333332

1131.0

Domain

SH2

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

242_493

26.333333333333332

1131.0

Domain

Protein kinase

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

61_121

26.333333333333332

1131.0

Domain

SH3

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

127_217

26.333333333333332

1131.0

Domain

SH2

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

242_493

26.333333333333332

1131.0

Domain

Protein kinase

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

61_121

26.333333333333332

1131.0

Domain

SH3

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

127_217

84.33333333333333

1131.0

Domain

SH2

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

242_493

84.33333333333333

1131.0

Domain

Protein kinase

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

127_217

26.333333333333332

1131.0

Domain

SH2

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

242_493

26.333333333333332

1131.0

Domain

Protein kinase

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

61_121

26.333333333333332

1131.0

Domain

SH3

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

1090_1100

26.333333333333332

1131.0

Motif

Nuclear export signal

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

381_405

26.333333333333332

1131.0

Motif

Note=Kinase activation loop

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

709_715

26.333333333333332

1131.0

Motif

Nuclear localization signal 2

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

762_769

26.333333333333332

1131.0

Motif

Nuclear localization signal 3

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

1090_1100

26.333333333333332

1131.0

Motif

Nuclear export signal

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

381_405

26.333333333333332

1131.0

Motif

Note=Kinase activation loop

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

709_715

26.333333333333332

1131.0

Motif

Nuclear localization signal 2

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

762_769

26.333333333333332

1131.0

Motif

Nuclear localization signal 3

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

1090_1100

26.333333333333332

1131.0

Motif

Nuclear export signal

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

381_405

26.333333333333332

1131.0

Motif

Note=Kinase activation loop

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

709_715

26.333333333333332

1131.0

Motif

Nuclear localization signal 2

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

762_769

26.333333333333332

1131.0

Motif

Nuclear localization signal 3

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

1090_1100

84.33333333333333

1131.0

Motif

Nuclear export signal

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

381_405

84.33333333333333

1131.0

Motif

Note=Kinase activation loop

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

709_715

84.33333333333333

1131.0

Motif

Nuclear localization signal 2

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

762_769

84.33333333333333

1131.0

Motif

Nuclear localization signal 3

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

1090_1100

26.333333333333332

1131.0

Motif

Nuclear export signal

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

381_405

26.333333333333332

1131.0

Motif

Note=Kinase activation loop

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

709_715

26.333333333333332

1131.0

Motif

Nuclear localization signal 2

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

762_769

26.333333333333332

1131.0

Motif

Nuclear localization signal 3

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

1090_1100

1131.0

Motif

Nuclear export signal

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

381_405

1131.0

Motif

Note=Kinase activation loop

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

709_715

1131.0

Motif

Nuclear localization signal 2

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

762_769

1131.0

Motif

Nuclear localization signal 3

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

1090_1100

26.333333333333332

1131.0

Motif

Nuclear export signal

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

381_405

26.333333333333332

1131.0

Motif

Note=Kinase activation loop

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

709_715

26.333333333333332

1131.0

Motif

Nuclear localization signal 2

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

762_769

26.333333333333332

1131.0

Motif

Nuclear localization signal 3

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

1090_1100

26.333333333333332

1131.0

Motif

Nuclear export signal

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

381_405

26.333333333333332

1131.0

Motif

Note=Kinase activation loop

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

709_715

26.333333333333332

1131.0

Motif

Nuclear localization signal 2

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

762_769

26.333333333333332

1131.0

Motif

Nuclear localization signal 3

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

1090_1100

84.33333333333333

1131.0

Motif

Nuclear export signal

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

381_405

84.33333333333333

1131.0

Motif

Note=Kinase activation loop

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

709_715

84.33333333333333

1131.0

Motif

Nuclear localization signal 2

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

762_769

84.33333333333333

1131.0

Motif

Nuclear localization signal 3

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

1090_1100

26.333333333333332

1131.0

Motif

Nuclear export signal

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

381_405

26.333333333333332

1131.0

Motif

Note=Kinase activation loop

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

709_715

26.333333333333332

1131.0

Motif

Nuclear localization signal 2

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

762_769

26.333333333333332

1131.0

Motif

Nuclear localization signal 3

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

1090_1100

26.333333333333332

1131.0

Motif

Nuclear export signal

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

381_405

26.333333333333332

1131.0

Motif

Note=Kinase activation loop

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

709_715

26.333333333333332

1131.0

Motif

Nuclear localization signal 2

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

762_769

26.333333333333332

1131.0

Motif

Nuclear localization signal 3

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

1090_1100

84.33333333333333

1131.0

Motif

Nuclear export signal

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

381_405

84.33333333333333

1131.0

Motif

Note=Kinase activation loop

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

709_715

84.33333333333333

1131.0

Motif

Nuclear localization signal 2

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

762_769

84.33333333333333

1131.0

Motif

Nuclear localization signal 3

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

1090_1100

26.333333333333332

1131.0

Motif

Nuclear export signal

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

381_405

26.333333333333332

1131.0

Motif

Note=Kinase activation loop

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

709_715

26.333333333333332

1131.0

Motif

Nuclear localization signal 2

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

762_769

26.333333333333332

1131.0

Motif

Nuclear localization signal 3

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

248_256

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

316_322

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

248_256

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

316_322

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

248_256

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

316_322

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

248_256

84.33333333333333

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

316_322

84.33333333333333

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

248_256

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

316_322

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

248_256

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

316_322

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

248_256

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

316_322

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

248_256

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

316_322

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

248_256

84.33333333333333

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

316_322

84.33333333333333

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

248_256

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

316_322

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

248_256

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

316_322

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

248_256

84.33333333333333

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

316_322

84.33333333333333

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

248_256

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

316_322

26.333333333333332

1131.0

Nucleotide binding

Note=ATP

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

869_968

26.333333333333332

1131.0

Region

DNA-binding

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

953_1130

26.333333333333332

1131.0

Region

Note=F-actin-binding

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

869_968

26.333333333333332

1131.0

Region

DNA-binding

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

953_1130

26.333333333333332

1131.0

Region

Note=F-actin-binding

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

869_968

26.333333333333332

1131.0

Region

DNA-binding

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

953_1130

26.333333333333332

1131.0

Region

Note=F-actin-binding

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

869_968

84.33333333333333

1131.0

Region

DNA-binding

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

953_1130

84.33333333333333

1131.0

Region

Note=F-actin-binding

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

869_968

26.333333333333332

1131.0

Region

DNA-binding

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

953_1130

26.333333333333332

1131.0

Region

Note=F-actin-binding

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

1_60

1131.0

Region

Note=CAP

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

869_968

1131.0

Region

DNA-binding

Tgene

ABL1

chr22:23615905

chr9:133710870

ENST00000318560

953_1130

1131.0

Region

Note=F-actin-binding

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

869_968

26.333333333333332

1131.0

Region

DNA-binding

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

953_1130

26.333333333333332

1131.0

Region

Note=F-actin-binding

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

869_968

26.333333333333332

1131.0

Region

DNA-binding

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

953_1130

26.333333333333332

1131.0

Region

Note=F-actin-binding

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

869_968

84.33333333333333

1131.0

Region

DNA-binding

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

953_1130

84.33333333333333

1131.0

Region

Note=F-actin-binding

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

869_968

26.333333333333332

1131.0

Region

DNA-binding

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

953_1130

26.333333333333332

1131.0

Region

Note=F-actin-binding

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

869_968

26.333333333333332

1131.0

Region

DNA-binding

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

953_1130

26.333333333333332

1131.0

Region

Note=F-actin-binding

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

869_968

84.33333333333333

1131.0

Region

DNA-binding

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

953_1130

84.33333333333333

1131.0

Region

Note=F-actin-binding

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

869_968

26.333333333333332

1131.0

Region

DNA-binding

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

953_1130

26.333333333333332

1131.0

Region

Note=F-actin-binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000305877

824_827

426.3333333333333

1272.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000359540

824_827

426.3333333333333

1228.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000305877

824_827

426.3333333333333

1272.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000359540

824_827

426.3333333333333

1228.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000305877

824_827

426.3333333333333

1272.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000359540

824_827

426.3333333333333

1228.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000305877

824_827

426.3333333333333

1272.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000359540

824_827

426.3333333333333

1228.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000305877

824_827

640.3333333333334

1272.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000359540

824_827

640.3333333333334

1228.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000305877

824_827

1272.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000359540

824_827

1228.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000305877

824_827

1272.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000359540

824_827

1228.0

Compositional bias

Note=Poly-Leu

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000305877

1054_1248

426.3333333333333

1272.0

Domain

Rho-GAP

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000305877

498_691

426.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000305877

708_866

426.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000305877

893_1020

426.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000359540

1054_1248

426.3333333333333

1228.0

Domain

Rho-GAP

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000359540

498_691

426.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000359540

708_866

426.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729448

ENST00000359540

893_1020

426.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000305877

1054_1248

426.3333333333333

1272.0

Domain

Rho-GAP

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000305877

498_691

426.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000305877

708_866

426.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000305877

893_1020

426.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000359540

1054_1248

426.3333333333333

1228.0

Domain

Rho-GAP

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000359540

498_691

426.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000359540

708_866

426.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729450

ENST00000359540

893_1020

426.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000305877

1054_1248

426.3333333333333

1272.0

Domain

Rho-GAP

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000305877

498_691

426.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000305877

708_866

426.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000305877

893_1020

426.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000359540

1054_1248

426.3333333333333

1228.0

Domain

Rho-GAP

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000359540

498_691

426.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000359540

708_866

426.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23524426

chr9:133729451

ENST00000359540

893_1020

426.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000305877

1054_1248

426.3333333333333

1272.0

Domain

Rho-GAP

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000305877

498_691

426.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000305877

708_866

426.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000305877

893_1020

426.3333333333333

1272.0

Domain

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000359540

1054_1248

426.3333333333333

1228.0

Domain

Rho-GAP

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000359540

498_691

426.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000359540

708_866

426.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23524430

chr9:133730185

ENST00000359540

893_1020

426.3333333333333

1228.0

Domain

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000305877

1054_1248

640.3333333333334

1272.0

Domain

Rho-GAP

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000305877

498_691

640.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000305877

708_866

640.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000305877

893_1020

640.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000359540

1054_1248

640.3333333333334

1228.0

Domain

Rho-GAP

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000359540

498_691

640.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000359540

708_866

640.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23613779

chr9:133729451

ENST00000359540

893_1020

640.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000305877

1054_1248

1272.0

Domain

Rho-GAP

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000305877

498_691

1272.0

Domain

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000305877

708_866

1272.0

Domain

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000305877

893_1020

1272.0

Domain

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000359540

1054_1248

1228.0

Domain

Rho-GAP

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000359540

498_691

1228.0

Domain

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000359540

708_866

1228.0

Domain

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000359540

893_1020

1228.0

Domain

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000305877

1054_1248

1272.0

Domain

Rho-GAP

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000305877

498_691

1272.0

Domain

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000305877

708_866

1272.0

Domain

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000305877

893_1020

1272.0

Domain

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000359540

1054_1248

1228.0

Domain

Rho-GAP

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000359540

498_691

1228.0

Domain

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000359540

708_866

1228.0

Domain

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000359540

893_1020

1228.0

Domain

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000305877

1054_1248

902.3333333333334

1272.0

Domain

Rho-GAP

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000305877

893_1020

902.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000359540

1054_1248

902.3333333333334

1228.0

Domain

Rho-GAP

Hgene

BCR

chr22:23631808

chr9:133729449

ENST00000359540

893_1020

902.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000305877

1054_1248

902.3333333333334

1272.0

Domain

Rho-GAP

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000305877

893_1020

902.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000359540

1054_1248

902.3333333333334

1228.0

Domain

Rho-GAP

Hgene

BCR

chr22:23631811

chr9:133730186

ENST00000359540

893_1020

902.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000305877

1054_1248

927.3333333333334

1272.0

Domain

Rho-GAP

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000305877

893_1020

927.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000359540

1054_1248

927.3333333333334

1228.0

Domain

Rho-GAP

Hgene

BCR

chr22:23632600

chr9:133729450

ENST00000359540

893_1020

927.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000305877

1054_1248

927.3333333333334

1272.0

Domain

Rho-GAP

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000305877

893_1020

927.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000359540

1054_1248

927.3333333333334

1228.0

Domain

Rho-GAP

Hgene

BCR

chr22:23632600

chr9:133729451

ENST00000359540

893_1020

927.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000305877

1054_1248

927.3333333333334

1272.0

Domain

Rho-GAP

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000305877

893_1020

927.3333333333334

1272.0

Domain

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000359540

1054_1248

927.3333333333334

1228.0

Domain

Rho-GAP

Hgene

BCR

chr22:23632602

chr9:133730188

ENST00000359540

893_1020

927.3333333333334

1228.0

Domain

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000305877

1054_1248

1107.3333333333333

1272.0

Domain

Rho-GAP

Hgene

BCR

chr22:23654023

chr9:133729451

ENST00000359540

1054_1248

1063.3333333333333

1228.0

Domain

Rho-GAP

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000305877

197_385

1272.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000305877

1_426

1272.0

Region

Note=Kinase

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000359540

197_385

1228.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23615905

chr9:133710870

ENST00000359540

1_426

1228.0

Region

Note=Kinase

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000305877

197_385

1272.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000305877

1_426

1272.0

Region

Note=Kinase

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000359540

197_385

1228.0

Region

Note=Binding to ABL SH2-domain

Hgene

BCR

chr22:23631779

chr9:133729451

ENST00000359540

1_426

1228.0

Region

Note=Kinase

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

18_22

26.333333333333332

1131.0

Compositional bias

Note=Poly-Ser

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

18_22

26.333333333333332

1131.0

Compositional bias

Note=Poly-Ser

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

18_22

26.333333333333332

1131.0

Compositional bias

Note=Poly-Ser

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

18_22

84.33333333333333

1131.0

Compositional bias

Note=Poly-Ser

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

18_22

26.333333333333332

1131.0

Compositional bias

Note=Poly-Ser

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

18_22

26.333333333333332

1131.0

Compositional bias

Note=Poly-Ser

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

18_22

26.333333333333332

1131.0

Compositional bias

Note=Poly-Ser

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

18_22

84.33333333333333

1131.0

Compositional bias

Note=Poly-Ser

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

18_22

26.333333333333332

1131.0

Compositional bias

Note=Poly-Ser

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

18_22

26.333333333333332

1131.0

Compositional bias

Note=Poly-Ser

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

18_22

84.33333333333333

1131.0

Compositional bias

Note=Poly-Ser

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

18_22

26.333333333333332

1131.0

Compositional bias

Note=Poly-Ser

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

61_121

84.33333333333333

1131.0

Domain

SH3

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

61_121

84.33333333333333

1131.0

Domain

SH3

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

61_121

84.33333333333333

1131.0

Domain

SH3

Tgene

ABL1

chr22:23524426

chr9:133729448

ENST00000318560

1_60

26.333333333333332

1131.0

Region

Note=CAP

Tgene

ABL1

chr22:23524426

chr9:133729450

ENST00000318560

1_60

26.333333333333332

1131.0

Region

Note=CAP

Tgene

ABL1

chr22:23524426

chr9:133729451

ENST00000318560

1_60

26.333333333333332

1131.0

Region

Note=CAP

Tgene

ABL1

chr22:23524430

chr9:133730185

ENST00000318560

1_60

84.33333333333333

1131.0

Region

Note=CAP

Tgene

ABL1

chr22:23613779

chr9:133729451

ENST00000318560

1_60

26.333333333333332

1131.0

Region

Note=CAP

Tgene

ABL1

chr22:23631779

chr9:133729451

ENST00000318560

1_60

26.333333333333332

1131.0

Region

Note=CAP

Tgene

ABL1

chr22:23631808

chr9:133729449

ENST00000318560

1_60

26.333333333333332

1131.0

Region

Note=CAP

Tgene

ABL1

chr22:23631811

chr9:133730186

ENST00000318560

1_60

84.33333333333333

1131.0

Region

Note=CAP

Tgene

ABL1

chr22:23632600

chr9:133729450

ENST00000318560

1_60

26.333333333333332

1131.0

Region

Note=CAP

Tgene

ABL1

chr22:23632600

chr9:133729451

ENST00000318560

1_60

26.333333333333332

1131.0

Region

Note=CAP

Tgene

ABL1

chr22:23632602

chr9:133730188

ENST00000318560

1_60

84.33333333333333

1131.0

Region

Note=CAP

Tgene

ABL1

chr22:23654023

chr9:133729451

ENST00000318560

1_60

26.333333333333332

1131.0

Region

Note=CAP

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (805) >>>805.pdbFusion protein BP residue: 6 CIF file (805) >>>805.cif	BCR	chr22	23631779	+	ABL1	chr9	133729451	+	MTINKEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALY DFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGR VYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKR NKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAV KTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL VGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYE LMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVS TLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSP LLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSS FREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPN GALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSAS CVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRR QVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPA EESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQ EAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAK PSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPE RIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSY VDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSS	1110
3D view using mol* of 805 (AA BP:6)


PDB file (937)CIF file (937) >>>937.cif	BCR	chr22	23524430	+	ABL1	chr9	133730185	+	MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVN QERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPA PADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPAS VAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRI SSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAE LNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQS SRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVS EATIVGVRKTGQIWPNDGEGAFHGDAGEKLRVLGYNHNGEWCEAQTKNGQ GWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSP GQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADG LITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYE GVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTRE PPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN FIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRM ERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEK ELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGE SDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKK KTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAK SPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGS SSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSE KPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGS SPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAG SGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAG KAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKP VLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLIST RVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLE AGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGP	1472
3D view using mol* of 937 (AA BP:)


PDB file (951) >>>951.pdbFusion protein BP residue: 426 CIF file (951) >>>951.cif	BCR	chr22	23524426	+	ABL1	chr9	133729448	+	MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVN QERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPA PADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPAS VAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRI SSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAE LNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQS SRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVS EATIVGVRKTGQIWPNDGEGAFHGDAEALQRPVASDFEPQGLSEAARWNS KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWC EAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFL VRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVH HHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGG GQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA MEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAK FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE LLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEM PHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLF SALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTP LDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLAT GEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSS TFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKD IMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEP VTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP PPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSST AFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQM ASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQIC	1530
3D view using mol* of 951 (AA BP:426)


PDB file (1008) >>>1008.pdbFusion protein BP residue: 637 CIF file (1008) >>>1008.cif	BCR	chr22	23613779	+	ABL1	chr9	133729451	+	MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVN QERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPA PADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPAS VAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRI SSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAE LNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQS SRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVS EATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRK WVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKV PELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLEKALQRPVASD FEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNA AEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYV SSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKE AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVN AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYG MSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSF AEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSR RAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNE DERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEE EGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHL WKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTL PRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRL VKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEA GKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPG RDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATS LVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLP SASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDST EALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREA	1744
3D view using mol* of 1008 (AA BP:637)


PDB file (1073)CIF file (1073) >>>1073.cif	BCR	chr22	23631811	+	ABL1	chr9	133730186	+	MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVN QERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPA PADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPAS VAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRI SSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAE LNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQS SRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVS EATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRK WVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKV PELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRV TRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMT VKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQ YDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQR EKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISS DYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN KEGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPV SRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDG KLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADF GLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEI ATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSD RPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKT RTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEG GLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRG AGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFR SPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWR SVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTP PPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPH KEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSS ESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKT KATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVP STLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVV LDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFA	1948
3D view using mol* of 1073 (AA BP:)


PDB file (1081)CIF file (1081) >>>1081.cif	BCR	chr22	23632602	+	ABL1	chr9	133730188	+	MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVN QERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPA PADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPAS VAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRI SSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAE LNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQS SRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVS EATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRK WVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKV PELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRV TRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMT VKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQ YDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQR EKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISS DYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN KEDDESPGLYGFLNVIVHSATGFKQSSSEKLRVLGYNHNGEWCEAQTKNG QGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESS PGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVAD GLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVY EGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTR EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA PESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYR MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVE KELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQG ESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKK KKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPA KSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGG SSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKS EKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPG SSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKA GSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASA GKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKK PVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLIS TRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVL EAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSG	1973
3D view using mol* of 1081 (AA BP:)


PDB file (1085)CIF file (1085) >>>1085.cif	BCR	chr22	23631808	+	ABL1	chr9	133729449	+	MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVN QERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPA PADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPAS VAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRI SSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAE LNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQS SRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVS EATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRK WVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKV PELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRV TRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMT VKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQ YDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQR EKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISS DYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN KEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVA SGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEK HSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPT VYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLL DYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN HLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWA FGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA CWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQ APELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPR KERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREM DGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALR ESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPH GAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQ VTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTV APASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESR VRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAG EAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGT PISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIAS GAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSI QQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEI	2006
3D view using mol* of 1085 (AA BP:)


PDB file (1090)CIF file (1090) >>>1090.cif	BCR	chr22	23632600	+	ABL1	chr9	133729450	+	MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVN QERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPA PADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPAS VAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRI SSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAE LNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQS SRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVS EATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRK WVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKV PELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRV TRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMT VKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQ YDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQR EKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISS DYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN KEDDESPGLYGFLNVIVHSATGFKQSSKALQRPVASDFEPQGLSEAARWN SKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEW CEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSF LVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELV HHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLG GGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLV QLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISS AMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGA KFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY ELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQE SSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPE MPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNL FSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFT PLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLA TGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDS STFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFK DIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAE PVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAP PPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPS QPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSS TAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQ MASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQI	2031
3D view using mol* of 1090 (AA BP:)


PDB file (1106)CIF file (1106) >>>1106.cif	BCR	chr22	23654023	+	ABL1	chr9	133729451	+	MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVN QERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPA PADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPAS VAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRI SSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAE LNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQS SRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVS EATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRK WVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKV PELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRV TRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMT VKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQ YDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQR EKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISS DYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN KEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVY RDTAEPNWNELDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMP SRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGV ATDIQALKAAFDVKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDP NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPS NYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSI SLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTL HYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKK YSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYI ITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY NKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEG CPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQ GVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLD HEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPT PPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPS NGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRF LRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALP RKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNL TPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPG GTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGK PSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPAT PKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLR KTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNL YTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQD	2167
3D view using mol* of 1106 (AA BP:)


PDB file (1112)CIF file (1112) >>>1112.cif	BCR	chr22	23654023	+	ABL1	chr9	133729451	+	MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVN QERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPA PADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPAS VAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRI SSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAE LNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQS SRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVS EATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRK WVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKV PELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRV TRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMT VKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQ YDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQR EKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISS DYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN KEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVY RDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGK GQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTG VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQA LKAAFDVKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVAL YDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPV NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEG RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK RNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVA VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMT YGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNC LVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIK SDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVY ELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAV STLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVS PLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSS SFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVP NGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSA SCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGE NRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLR RQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGP AEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPS QEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSA KPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPP ERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVS YVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLS	2211
3D view using mol* of 1112 (AA BP:)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

BCR_pLDDT.png

ABL1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

BCR_ABL1_805_pLDDT.png (AA BP:6)

BCR_ABL1_805_pLDDT_and_active_sites.png (AA BP:6)

BCR_ABL1_805_violinplot.png (AA BP:6)

BCR_ABL1_937_pLDDT_and_active_sites.png (AA BP:)

BCR_ABL1_937_violinplot.png (AA BP:)

BCR_ABL1_951_pLDDT.png (AA BP:426)

BCR_ABL1_951_pLDDT_and_active_sites.png (AA BP:426)

BCR_ABL1_951_violinplot.png (AA BP:426)

BCR_ABL1_1008_pLDDT.png (AA BP:637)

BCR_ABL1_1008_pLDDT_and_active_sites.png (AA BP:637)

BCR_ABL1_1008_violinplot.png (AA BP:637)

BCR_ABL1_1106_pLDDT_and_active_sites.png (AA BP:)

BCR_ABL1_1106_violinplot.png (AA BP:)

BCR_ABL1_1112_pLDDT_and_active_sites.png (AA BP:)

BCR_ABL1_1112_violinplot.png (AA BP:)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

BCR_ABL1_805.png

BCR_ABL1_951.png

BCR_ABL1_1008.png

BCR_ABL1_1073.png

BCR_ABL1_1081.png

BCR_ABL1_1085.png

BCR_ABL1_1090.png

BCR_ABL1_1106.png

BCR_ABL1_1112.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
805	1.0217	386	1.0372	1146.992	0.5321	0.7305	0.9531	0.7349	1.0464	0.7023	0.7893	Chain A: 226,227,228,229,230,231,232,233,234,236,2 49,251,253,257,259,262,263,266,270,279,293,295,296 ,297,298,299,300,301,302,304,305,306,308,309,310,3 42,343,344,347,348,350,360,361,362,363,364,365,366 ,373,375,376,379,380,381,382,385,386,387,390,396,4 00,401,404,712,713,714,715,716,717,718
937	1.061	87	1.129	196.539	0.522	0.725	1.018	1.92	0.559	3.435	1.672	Chain A: 51,52,54,55,57,58,59,62,200,203,204,206,2 07,208,210,211,212,214
951	1.05	190	1.058	533.365	0.488	0.772	1.024	0.892	1.058	0.843	0.735	Chain A: 648,649,650,651,652,653,654,656,669,670,6 71,679,682,686,690,699,713,715,716,717,718,721,722 ,762,763,767,768,770,780,781,782,784,786,793,795,7 96,799,800,801,802,816
1008	1.035839	259	1.06418	1095.885	0.657407	0.727666	0.808314	0.410771	0.958341	0.428627	0.687112	Chain A: 686,687,689,713,728,729,746,747,748,749,7 50,766,768,769,770,774,776,787,789,834,835,836,837 ,838,839,841,842,878,880,881,909,910,911,914,916,9 30,931,932,933,956,959,960,963,966,967,970,986,987 ,988,990,992,1101,1104,1105,1108,1109,1111,1112
1008	1.036	259	1.064	1095.885	0.657	0.728	0.808	0.411	0.958	0.429	0.687	Chain A: 686,687,689,713,728,729,746,747,748,749,7 50,766,768,769,770,774,776,787,789,834,835,836,837 ,838,839,841,842,878,880,881,909,910,911,914,916,9 30,931,932,933,956,959,960,963,966,967,970,986,987 ,988,990,992,1101,1104,1105,1108,1109,1111,1112
1073	1.052	207	1.042	525.819	0.427	0.776	1.042	0.844	1.117	0.755	0.841	Chain A: 1066,1067,1068,1069,1070,1071,1074,1087,1 088,1089,1097,1100,1104,1108,1117,1131,1133,1134,1 135,1136,1139,1140,1179,1180,1181,1185,1186,1188,1 198,1199,1200,1201,1202,1203,1204,1211,1213,1214,1 217,1218,1219,1220,1234
1081	1.075	120	1.139	266.511	0.526	0.713	0.97	2.159	0.702	3.077	1.096	Chain A: 1175,1179,1180,1183,1184,1187,1272,1273,1 275,1276,1277,1278,1280,1284,1299,1301,1302,1303,1 304,1305,1306,1307,1308,1311,1336,1340,1345,1346,1 349,1350,1353
1085	1.031	202	1.017	546.056	0.505	0.744	0.959	0.739	1.134	0.652	0.714	Chain A: 1124,1125,1127,1128,1129,1130,1132,1145,1 147,1153,1154,1155,1158,1162,1166,1175,1189,1191,1 192,1193,1194,1197,1198,1237,1238,1239,1243,1244,1 246,1256,1257,1258,1259,1260,1261,1262,1269,1271,1 272,1275,1276,1277,1278,1292
1090	1.019	198	1.078	551.887	0.675	0.647	0.852	0.768	0.767	1.002	0.805	Chain A: 505,506,509,511,512,513,514,515,516,518,5 19,522,523,526,554,557,558,560,581,584,585,588,591 ,618,620,621,622,623,624,625,626,627,633,635,636,6 37,645,648,649,650,652,653,656,657,677,681
1106	1.061522	261	1.122442	746.025	0.528881	0.700298	0.905908	1.112799	0.729253	1.525943	0.965653	Chain A: 1008,1025,1026,1029,1030,1032,1033,1034,1 036,1037,1041,1042,1043,1044,1047,1048,1049,1050,1 053,1054,1056,1057,1058,1060,1061,1064,1069,1071,1 074,1075,1076,1077,1078,1079,1080,1081,1082,1083,1 084,1085,1252
1106	1.062	261	1.122	746.025	0.529	0.7	0.906	1.113	0.729	1.526	0.966	Chain A: 1008,1025,1026,1029,1030,1032,1033,1034,1 036,1037,1041,1042,1043,1044,1047,1048,1049,1050,1 053,1054,1056,1057,1058,1060,1061,1064,1069,1071,1 074,1075,1076,1077,1078,1079,1080,1081,1082,1083,1 084,1085,1252
1112	1.06	356	1.084	968.975	0.489	0.768	0.949	0.518	0.973	0.532	0.79	Chain A: 345,346,347,348,350,351,352,353,354,711,7 12,713,714,715,792,795,796,798,799,802,815,818,826 ,830,848,849,852,853,856,857,892,893,894,896,897,8 98,899,900,901,902,903,904,905,906,907,908,910,936 ,938,939,940,941,968,970,971,973,1004,1005,1006,10 07

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB	ZINC ID	DrugBank ID	Drug name	Docking score	Glide gscore
951	ZINC000000968330	DB00412	Rosiglitazone	-8.64188	-9.20868
951	ZINC000019632614	DB00317	Gefitinib	-8.64695	-9.06195
951	ZINC000000968326	DB01132	Pioglitazone	-8.48853	-8.92863
951	ZINC000027990463	DB08827	Lomitapide	-8.52136	-8.52446
951	ZINC000005733652	DB11259	Diosmetin	-8.46609	-8.50209
951	ZINC000019203912	DB00623	Fluphenazine	-7.88147	-8.42877
951	ZINC000001995484	DB01610	Valganciclovir	-8.18901	-8.40231
951	ZINC000053683345	DB05294	Vandetanib	-8.26725	-8.26725
951	ZINC000011617039	DB06589	Pazopanib	-8.17782	-8.18472
951	ZINC000021303210	DB00484	Brimonidine	-6.68196	-8.18356
951	ZINC000034220093	DB15058	Flutemetamol	-8.13953	-8.15363
951	ZINC000004098633	DB11263	Polydatin	-7.99163	-7.99163
951	ZINC000036701290	DB08901	Ponatinib	-7.74572	-7.95232
951	ZINC000000968327	DB01132	Pioglitazone	-7.3915	-7.8742
951	ZINC000003810860	DB00973	Ezetimibe	-7.85532	-7.85592
951	ZINC000003812851	DB09477	Enalaprilat	-6.85225	-7.82875
951	ZINC000000020253	DB00310	Chlorthalidone	-7.80733	-7.80873
951	ZINC000003830946	DB01362	Iohexol	-7.78754	-7.78754
951	ZINC000000001984	DB13873	Fenofibric acid	-7.78099	-7.78099
951	ZINC000252679615	DB01219	Dantrolene	-7.69151	-7.76391

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID	DrugBank ID	Drug name	Drug type	SMILES	Drug group
ZINC000000968330	DB00412	Rosiglitazone	Small molecule	CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C1=CC=CC=N1	Approved\|Investigational
ZINC000019632614	DB00317	Gefitinib	Small molecule	COC1=C(OCCCN2CCOCC2)C=C2C(NC3=CC(Cl)=C(F)C=C3)=NC=NC2=C1	Approved\|Investigational
ZINC000027990463	DB08827	Lomitapide	Small molecule	FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)C2=C(C=CC=C2)C2=CC=C(C=C2)C(F)(F)F)C2=CC=CC=C2C2=CC=CC=C12	Approved\|Investigational
ZINC000005733652	DB11259	Diosmetin	Small molecule	COC1=C(O)C=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2O	Experimental
ZINC000019203912	DB00623	Fluphenazine	Small molecule	OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	Approved
ZINC000053683345	DB05294	Vandetanib	Small molecule	COC1=C(OCC2CCN(C)CC2)C=C2N=CN=C(NC3=C(F)C=C(Br)C=C3)C2=C1	Approved
ZINC000011617039	DB06589	Pazopanib	Small molecule	CN(C1=CC2=NN(C)C(C)=C2C=C1)C1=CC=NC(NC2=CC=C(C)C(=C2)S(N)(=O)=O)=N1	Approved
ZINC000021303210	DB00484	Brimonidine	Small molecule	BrC1=C(NC2=NCCN2)C=CC2=NC=CN=C12	Approved
ZINC000034220093	DB15058	Flutemetamol	Small molecule	CNC1=C(F)C=C(C=C1)C1=NC2=C(S1)C=C(O)C=C2	Investigational
ZINC000004098633	DB11263	Polydatin	Small molecule	OC[C@H]1O[C@@H](OC2=CC(C=CC3=CC=C(O)C=C3)=CC(O)=C2)[C@H](O)[C@@H](O)[C@@H]1O	Approved
ZINC000036701290	DB08901	Ponatinib	Small molecule	CN1CCN(CC2=CC=C(NC(=O)C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C)C=C3)C=C2C(F)(F)F)CC1	Approved\|Investigational
ZINC000000968327	DB01132	Pioglitazone	Small molecule	CCC1=CN=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)C=C1	Approved\|Investigational
ZINC000003810860	DB00973	Ezetimibe	Small molecule	[H][C@]1(CC[C@H](O)C2=CC=C(F)C=C2)C(=O)N(C2=CC=C(F)C=C2)[C@]1([H])C1=CC=C(O)C=C1	Approved
ZINC000003812851	DB09477	Enalaprilat	Small molecule	[H][C@@](C)(N[C@@]([H])(CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@@]1([H])C(O)=O	Approved
ZINC000000001984	DB13873	Fenofibric acid	Small molecule	CC(C)(OC1=CC=C(C=C1)C(=O)C1=CC=C(Cl)C=C1)C(O)=O	Approved

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID	mol_MW	dipole	SASA	FOSA	FISA	PISA	WPSA	volume	donorHB	accptHB	IP	Human Oral Absorption	Percent Human Oral Absorption	Rule Of Five	Rule Of Three
ZINC000000968330	357.426	1.368	624.189	191.363	122.323	275.294	35.209	1104.245	1	5.25	8.364	3	100	0	0
ZINC000000968330	357.426	1.059	632.881	175.808	136.284	288.282	32.506	1111.814	1	5.25	8.367	3	96.285	0	0
ZINC000000968330	357.426	2.667	631.991	174.467	135.907	288.934	32.682	1112.198	1	5.25	8.43	3	96.39	0	0
ZINC000000968330	357.426	3.759	634.057	177.006	120.765	293.193	43.093	1110.566	1	5.25	8.52	3	100	0	0
ZINC000019632614	446.908	5.605	766.017	373.784	38.968	243.44	109.824	1351.73	1	7.7	8.493	3	100	0	0
ZINC000019632614	446.908	5.389	803.125	411.613	39.025	242.679	109.806	1392.008	1	7.7	8.484	3	100	0	1
ZINC000000968326	356.439	4.606	651.231	258.441	124.988	224.396	43.407	1141.924	1	4.75	9.063	3	100	0	0
ZINC000000968326	356.439	3.454	646.881	263.838	124.365	223.676	35.003	1134.988	1	4.75	9.205	3	100	0	0
ZINC000000968326	356.439	2.644	650.951	259.64	127.388	220.5	43.423	1141.593	1	4.75	9.146	3	100	0	0
ZINC000000968326	356.439	3.415	646.869	264.846	124.171	223.69	34.163	1135.111	1	4.75	9.231	3	100	0	0
ZINC000027990463	693.731	9.819	1082.565	277.602	57.032	525.312	222.618	2026.285	2	7	9.293	1	100	2	1
ZINC000027990463	693.731	5.182	1032.195	249.812	56.285	513.578	212.521	1985.783	2	7	9.074	1	100	2	1
ZINC000005733652	300.267	4.88	528.855	93.31	204.424	231.12	0	896.841	2	4.5	8.9	3	73.982	0	0
ZINC000005733652	300.267	6.652	527.118	93.294	202.511	231.313	0	894.005	2	4.5	8.908	3	74.287	0	0
ZINC000019203912	437.522	1.866	667.705	280.393	37.632	229.684	119.996	1257.681	1	6.2	8.126	3	95.44	0	1
ZINC000019203912	437.522	3.481	669.797	259.989	57.21	232.5	120.098	1250.575	1	6.2	8.155	3	91.657	0	1
ZINC000019203912	437.522	3.695	710.047	257.018	59.375	274.093	119.561	1303.382	1	6.2	8.086	3	92.087	0	1
ZINC000001995484	354.365	9.631	568.054	246.752	278.137	43.166	0	1064.885	6	11.9	8.542	1	5.895	2	1
ZINC000001995484	354.365	11.53	614.893	262.115	314.103	38.675	0	1087.654	6	11.9	8.454	1	0	2	1
ZINC000053683345	475.36	2.632	744.897	354.919	63.016	207.196	119.766	1322.708	1	6	8.608	3	100	0	1
ZINC000053683345	475.36	1.427	734.862	346.066	63.02	205.993	119.784	1318.245	1	6	8.627	3	100	0	1
ZINC000011617039	437.518	10.6	726.976	265.015	179.244	281.029	1.688	1314.793	3	8.5	8.135	3	84.594	0	0
ZINC000011617039	437.518	10.103	762.22	291.828	179.938	288.774	1.679	1339.843	3	8.5	8.165	3	85.215	0	1
ZINC000021303210	292.137	6.158	468.026	121.643	92.067	199.954	54.362	770.881	2	4.5	8.173	3	94.201	0	0
ZINC000021303210	292.137	5.435	472.224	121.785	84.492	200.341	65.605	771.78	2	4	8.267	3	100	0	0
ZINC000034220093	274.312	1.949	511.177	89.833	86.339	254.76	80.245	847.322	2	3.25	8.207	3	100	0	0
ZINC000034220093	274.312	1.174	509.609	89.83	84.419	255.176	80.184	844.623	2	3.25	8.146	3	100	0	0
ZINC000004098633	390.389	7.667	669.829	130.628	272.364	266.837	0	1181.188	6	10.75	8.482	2	40.085	1	0
ZINC000036701290	532.567	7.296	915.546	310.158	106.613	405.085	93.689	1633.531	1	9.5	8.988	1	72.323	1	1
ZINC000036701290	532.567	4.435	904.567	311.4	106.915	392.831	93.42	1625.419	1	9.5	9.023	2	71.892	1	1
ZINC000036701290	532.567	10.427	912.404	310.981	99.059	408.312	94.052	1630.814	1	9.5	8.961	2	73.847	1	1
ZINC000000968327	356.439	3.797	649.705	257.697	124.274	224.356	43.379	1140.406	1	4.75	9.075	3	100	0	0
ZINC000000968327	356.439	2.594	661.839	250.138	139.459	239.977	32.265	1145.281	1	4.75	9.184	3	100	0	0
ZINC000000968327	356.439	2.857	652.728	259.013	125.786	224.546	43.384	1142.385	1	4.75	9.131	3	100	0	0
ZINC000000968327	356.439	3.362	661.519	250.269	140.099	238.95	32.2	1145.298	1	4.75	9.214	3	100	0	0
ZINC000003810860	409.432	5.656	707.471	74.233	136.697	402.908	93.634	1265.987	2	4.45	8.806	1	91.961	1	1
ZINC000003812851	348.398	6.966	641.394	254.033	191.246	196.115	0	1140.873	3	8.5	9.564	1	26.276	0	1
ZINC000003812851	348.398	4.145	640.484	264.788	180.263	195.433	0	1137.41	3	8.5	9.243	1	28.647	0	1
ZINC000000020253	338.765	5.817	531.475	0	243.204	234.864	53.406	910.356	4	7.75	10.189	2	59.233	0	0
ZINC000003830946	821.143	5.327	787.47	294	369.208	9.789	114.474	1488.253	8	18.2	9.631	1	0	3	1
ZINC000000001984	318.756	1.815	576.755	125.702	133.148	246.378	71.527	990.252	1	4.75	9.562	3	86.64	0	0
ZINC000252679615	314.257	3.867	548.758	54.323	243.185	251.25	0	924.46	1	5	9.205	3	67.058	0	0
ZINC000252679615	314.257	2.557	527.996	64.383	238.233	225.38	0	905.494	1	5	9.686	3	67.506	0	0
ZINC000252679615	314.257	4.186	547.3	54.729	241.127	251.444	0	922.097	1	5	9.191	3	67.408	0	0
ZINC000252679615	314.257	2.845	525.884	65.15	235.939	224.795	0	902.055	1	5	9.671	3	67.875	0	0

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID	Smile	Surface Accessibility	Toxicity
ZINC000000968330	CN(CCOc1ccc(C[C@H]2SC(=O)NC2=O)cc1)c1ccccn1	0.155326871	0.273380926
ZINC000019632614	COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1	0.262538498	0.113127421
ZINC000000968326	CCc1ccc(CCOc2ccc(C[C@@H]3SC(=O)NC3=O)cc2)nc1	0.162255791	0.381863632
ZINC000027990463	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	0.141091549	0.274261494
ZINC000005733652	COc1ccc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc1O	0.260199086	0.67867566
ZINC000019203912	OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	0.241606725	0.269532671
ZINC000001995484	CC(C)[C@H](N)C(=O)OC[C@H](CO)OCn1cnc2c(=O)[nH]c(N)nc21	0.066223161	0.39718523
ZINC000053683345	COc1cc2/c(=Nc3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	0.142506791	0.289267966
ZINC000011617039	Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O	0.172624923	0.317118908
ZINC000021303210	Brc1c(N=C2NCCN2)ccc2nccnc12	0.083891766	0.518555162
ZINC000034220093	CNc1ccc(-c2nc3ccc(O)cc3s2)cc1F	0.301158621	0.239116152
ZINC000004098633	OC[C@H]1O[C@@H](Oc2cc(O)cc(/C=C/c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O	0.067882318	0.512213372
ZINC000036701290	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	0.143352927	0.289072356
ZINC000000968327	CCc1ccc(CCOc2ccc(C[C@H]3SC(=O)NC3=O)cc2)nc1	0.162255791	0.381863632
ZINC000003810860	O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1	0.113783441	0.30369071
ZINC000003812851	C[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N1CCC[C@H]1C(=O)O	0.137466306	0.184902995
ZINC000000020253	NS(=O)(=O)c1cc([C@]2(O)NC(=O)c3ccccc32)ccc1Cl	0.128141978	0.345401829
ZINC000003830946	CC(=O)N(C[C@@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(C(=O)NC[C@@H](O)CO)c1I	0.042332243	0.211666342
ZINC000000001984	CC(C)(Oc1ccc(C(=O)c2ccc(Cl)cc2)cc1)C(=O)O	0.435847957	0.410312877
ZINC000252679615	O=C1CN(N=Cc2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(O)=N1	0.149132109	0.500589886

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

BCR

MLLT4, HCK, PTPN6, FES, RB1, ERCC3, GRB2, ABL1, GAB2, HOXA9, CRKL, KIT, PIK3CG, IGSF21, TP53, UNC119, SOS1, PXN, RAC1, CDC42, RHOA, IL3, WDR48, TSG101, VPS28, INPP5D, MYC, HSP90AA1, HSPA8, HIF1A, CRK, GABRR1, CBL, LNX1, LRRK1, GRK5, UBASH3B, PIK3R2, SHC1, AP2M1, Grasp, CFTR, ERBB2IP, DOK1, PTGES3, HSPA4, HSPD1, UBC, CSNK2A2, STUB1, CCDC183, RSPH9, SEC13, Numb, NTRK1, CEP128, NINL, XPO1, Scai, PIK3R1, PDZK1, COMMD1, TULP3, JPH4, NAGK, USP15, SPAG9, MCM2, MCM4, WEE1, CSNK1A1, MCM6, TRIM25, RAD51, HNRNPL, EGLN3, ESR2, DPF2, RECQL4, EZR, KIAA1429, SCAI, HOOK3, PTPN3, PLK1, PLEKHA4, nsp12, nsp15, nsp2, ARHGEF39, HSCB, SAMD4B, SMG6, BRPF3, CECR2, SP110, TRIM66, AP2A1, CSNK2A1, DDX58, USP1, ACTR1A, ANK3, AP2B1, CEP135, CLTA, CTNNA1, DCTN2, MAPRE3, PFN1, RAB2A, RDX, RHOB, SQSTM1, VASP, ATG7, ATG10, ATG3, MAP4K1, NUDCD2, VPS33A, PSD4, SLA2, AGO4, DDR1, YWHAB, NAA10, YWHAH, YWHAG, SURF6, SYNC, CSNK2B, BACE2, GRAP2,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
BCR
ABL1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to BCR-ABL1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Drug	Source	PMID
BCR	ABL1	Imatinib	PubMed	32000382
BCR	ABL1	Dasatinib	MyCancerGenome
BCR	ABL1	Bosutinib	MyCancerGenome
BCR	ABL1	Nilotinib	MyCancerGenome
BCR	ABL1	Imatinib	MyCancerGenome
BCR	ABL1	Ponatinib	MyCancerGenome

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Related Diseases to BCR-ABL1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
BCR	ABL1	Chronic Myelogenous Leukemi	PubMed	32000382
BCR	ABL1	Chronic Myeloid Leukemia	MyCancerGenome
BCR	ABL1	Breast Invasive Ductal Carcinoma	MyCancerGenome
BCR	ABL1	Unknown	MyCancerGenome
BCR	ABL1	B-Cell Lymphoblastic Leukemia/Lymphoma	MyCancerGenome
BCR	ABL1	Acute Myeloid Leukemia	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	BCR	C0005586	Bipolar Disorder	4	PSYGENET
Hgene	BCR	C0023473	Myeloid Leukemia, Chronic	3	CTD_human;ORPHANET
Hgene	BCR	C0005699	Blast Phase	1	CTD_human
Hgene	BCR	C0006413	Burkitt Lymphoma	1	ORPHANET
Hgene	BCR	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	BCR	C0027022	Myeloproliferative disease	1	CTD_human
Hgene	BCR	C0027540	Necrosis	1	CTD_human
Hgene	BCR	C0027659	Neoplasms, Experimental	1	CTD_human
Hgene	BCR	C0041696	Unipolar Depression	1	PSYGENET
Hgene	BCR	C1269683	Major Depressive Disorder	1	PSYGENET
Hgene	BCR	C1292769	Precursor B-cell lymphoblastic leukemia	1	ORPHANET
Tgene	ABL1	C0023473	Myeloid Leukemia, Chronic	3	CGI;CTD_human;ORPHANET
Tgene	ABL1	C0023452	Childhood Acute Lymphoblastic Leukemia	2	CTD_human
Tgene	ABL1	C0023453	L2 Acute Lymphoblastic Leukemia	2	CTD_human
Tgene	ABL1	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	2	CGI;CTD_human
Tgene	ABL1	C0001418	Adenocarcinoma	1	CTD_human
Tgene	ABL1	C0003706	Arachnodactyly	1	GENOMICS_ENGLAND
Tgene	ABL1	C0005941	Bone Diseases, Developmental	1	CTD_human
Tgene	ABL1	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	ABL1	C0006413	Burkitt Lymphoma	1	ORPHANET
Tgene	ABL1	C0014859	Esophageal Neoplasms	1	CTD_human
Tgene	ABL1	C0015544	Failure to Thrive	1	CTD_human
Tgene	ABL1	C0018798	Congenital Heart Defects	1	CTD_human
Tgene	ABL1	C0023903	Liver neoplasms	1	CTD_human
Tgene	ABL1	C0027659	Neoplasms, Experimental	1	CTD_human
Tgene	ABL1	C0032927	Precancerous Conditions	1	CTD_human
Tgene	ABL1	C0039075	Syndactyly	1	GENOMICS_ENGLAND
Tgene	ABL1	C0151491	Congenital musculoskeletal anomalies	1	CTD_human
Tgene	ABL1	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Tgene	ABL1	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Tgene	ABL1	C0205643	Carcinoma, Cribriform	1	CTD_human
Tgene	ABL1	C0205644	Carcinoma, Granular Cell	1	CTD_human
Tgene	ABL1	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Tgene	ABL1	C0265610	Clinodactyly of fingers	1	GENOMICS_ENGLAND
Tgene	ABL1	C0282313	Condition, Preneoplastic	1	CTD_human
Tgene	ABL1	C0345904	Malignant neoplasm of liver	1	CTD_human
Tgene	ABL1	C0546837	Malignant neoplasm of esophagus	1	CTD_human
Tgene	ABL1	C0596263	Carcinogenesis	1	CTD_human
Tgene	ABL1	C0678222	Breast Carcinoma	1	CTD_human
Tgene	ABL1	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	ABL1	C1292769	Precursor B-cell lymphoblastic leukemia	1	ORPHANET
Tgene	ABL1	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	ABL1	C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1	CGI;ORPHANET
Tgene	ABL1	C4539857	CONGENITAL HEART DEFECTS AND SKELETAL MALFORMATIONS SYNDROME	1	GENOMICS_ENGLAND;UNIPROT
Tgene	ABL1	C4551485	Clinodactyly	1	GENOMICS_ENGLAND
Tgene	ABL1	C4704874	Mammary Carcinoma, Human	1	CTD_human