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Fusion Protein:BCR-RALGPS1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: BCR-RALGPS1 | FusionPDB ID: 9533 | FusionGDB2.0 ID: 9533 | Hgene | Tgene | Gene symbol | BCR | RALGPS1 | Gene ID | 613 | 9649 |
| Gene name | BCR activator of RhoGEF and GTPase | Ral GEF with PH domain and SH3 binding motif 1 | |
| Synonyms | ALL|BCR1|CML|D22S11|D22S662|PHL | RALGEF2|RALGPS1A | |
| Cytomap | 22q11.23 | 9q33.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | breakpoint cluster region proteinBCR, RhoGEF and GTPase activating proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26 | ras-specific guanine nucleotide-releasing factor RalGPS1Ral guanine nucleotide exchange factor RalGPS1Aral guanine nucleotide exchange factor 2ralA exchange factor RalGPS1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P11274 | . | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000305877, ENST00000359540, ENST00000398512, ENST00000436990, | ENST00000394011, ENST00000480993, ENST00000259351, ENST00000373434, ENST00000373436, ENST00000394022, ENST00000424082, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 22 X 142 X 16=49984 | 10 X 10 X 7=700 |
| # samples | 163 | 11 | |
| ** MAII score | log2(163/49984*10)=-4.93852248902354 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/700*10)=-2.66985139830767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: BCR [Title/Abstract] AND RALGPS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | BCR(23615961)-RALGPS1(129831507), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | BCR-RALGPS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BCR-RALGPS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BCR-RALGPS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BCR-RALGPS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BCR | GO:0090630 | activation of GTPase activity | 7479768 |
| Tgene | RALGPS1 | GO:0032485 | regulation of Ral protein signal transduction | 10747847 |
| Fusion gene breakpoints across BCR (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across RALGPS1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | acute lymphoblastic leukemia | HQ622706 | BCR | chr22 | 23615961 | RALGPS1 | chr9 | 129831507 | ||
| ChiTaRS5.0 | N/A | HQ622706 | BCR | chr22 | 23615961 | + | RALGPS1 | chr9 | 129831507 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000305877 | BCR | chr22 | 23615961 | ENST00000424082 | RALGPS1 | chr9 | 129831507 | 4441 | 2866 | 751 | 3996 | 1081 | ||
| ENST00000305877 | BCR | chr22 | 23615961 | ENST00000259351 | RALGPS1 | chr9 | 129831507 | 8452 | 2866 | 751 | 4056 | 1101 | ||
| ENST00000305877 | BCR | chr22 | 23615961 | ENST00000394022 | RALGPS1 | chr9 | 129831507 | 3763 | 2866 | 751 | 3537 | 928 | ||
| ENST00000305877 | BCR | chr22 | 23615961 | ENST00000373436 | RALGPS1 | chr9 | 129831507 | 3823 | 2866 | 751 | 3300 | 849 | ||
| ENST00000305877 | BCR | chr22 | 23615961 | ENST00000373434 | RALGPS1 | chr9 | 129831507 | 4784 | 2866 | 751 | 3972 | 1073 | ||
| ENST00000359540 | BCR | chr22 | 23615961 | ENST00000424082 | RALGPS1 | chr9 | 129831507 | 4286 | 2711 | 596 | 3841 | 1081 | ||
| ENST00000359540 | BCR | chr22 | 23615961 | ENST00000259351 | RALGPS1 | chr9 | 129831507 | 8297 | 2711 | 596 | 3901 | 1101 | ||
| ENST00000359540 | BCR | chr22 | 23615961 | ENST00000394022 | RALGPS1 | chr9 | 129831507 | 3608 | 2711 | 596 | 3382 | 928 | ||
| ENST00000359540 | BCR | chr22 | 23615961 | ENST00000373436 | RALGPS1 | chr9 | 129831507 | 3668 | 2711 | 596 | 3145 | 849 | ||
| ENST00000359540 | BCR | chr22 | 23615961 | ENST00000373434 | RALGPS1 | chr9 | 129831507 | 4629 | 2711 | 596 | 3817 | 1073 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000305877 | ENST00000424082 | BCR | chr22 | 23615961 | RALGPS1 | chr9 | 129831507 | 0.008668287 | 0.9913317 | ||
| ENST00000305877 | ENST00000259351 | BCR | chr22 | 23615961 | RALGPS1 | chr9 | 129831507 | 0.002965416 | 0.99703455 | ||
| ENST00000305877 | ENST00000394022 | BCR | chr22 | 23615961 | RALGPS1 | chr9 | 129831507 | 0.012387792 | 0.9876122 | ||
| ENST00000305877 | ENST00000373436 | BCR | chr22 | 23615961 | RALGPS1 | chr9 | 129831507 | 0.020122487 | 0.97987753 | ||
| ENST00000305877 | ENST00000373434 | BCR | chr22 | 23615961 | RALGPS1 | chr9 | 129831507 | 0.007583242 | 0.99241674 | ||
| ENST00000359540 | ENST00000424082 | BCR | chr22 | 23615961 | RALGPS1 | chr9 | 129831507 | 0.008591279 | 0.99140877 | ||
| ENST00000359540 | ENST00000259351 | BCR | chr22 | 23615961 | RALGPS1 | chr9 | 129831507 | 0.002694634 | 0.9973054 | ||
| ENST00000359540 | ENST00000394022 | BCR | chr22 | 23615961 | RALGPS1 | chr9 | 129831507 | 0.013502391 | 0.9864976 | ||
| ENST00000359540 | ENST00000373436 | BCR | chr22 | 23615961 | RALGPS1 | chr9 | 129831507 | 0.022579413 | 0.9774206 | ||
| ENST00000359540 | ENST00000373434 | BCR | chr22 | 23615961 | RALGPS1 | chr9 | 129831507 | 0.007250411 | 0.9927496 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >9533_9533_1_BCR-RALGPS1_BCR_chr22_23615961_ENST00000305877_RALGPS1_chr9_129831507_ENST00000259351_length(amino acids)=1101AA_BP=705 MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGELLNRKDKTTFEKLDY LMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVR YIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVES KSATFPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFSEEMSSGLESPTGPCICSLGNSAAVPTMEGPLRRKTLLKE GRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHK -------------------------------------------------------------- >9533_9533_2_BCR-RALGPS1_BCR_chr22_23615961_ENST00000305877_RALGPS1_chr9_129831507_ENST00000373434_length(amino acids)=1073AA_BP=705 MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGELLNRKDKTTFEKLDY LMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVR YIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNRGRLYATLGP NWRVPVRNSPRTRSCVYSPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHVSIVGW -------------------------------------------------------------- >9533_9533_3_BCR-RALGPS1_BCR_chr22_23615961_ENST00000305877_RALGPS1_chr9_129831507_ENST00000373436_length(amino acids)=849AA_BP=705 MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGELLNRKDKTTFEKLDY LMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVR -------------------------------------------------------------- >9533_9533_4_BCR-RALGPS1_BCR_chr22_23615961_ENST00000305877_RALGPS1_chr9_129831507_ENST00000394022_length(amino acids)=928AA_BP=705 MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGELLNRKDKTTFEKLDY LMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVR YIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAVSHLSSLSHQGQAEEARLKPTSGQHPAWMWPSSSRVPAAPPASAAPRSPWPRN -------------------------------------------------------------- >9533_9533_5_BCR-RALGPS1_BCR_chr22_23615961_ENST00000305877_RALGPS1_chr9_129831507_ENST00000424082_length(amino acids)=1081AA_BP=705 MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGELLNRKDKTTFEKLDY LMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVR YIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNRGRLYATLGP NWRVPVRNSPRTRSCVYSPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPG KKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQEAGAAPGPTGTDSHEVDHLEGGAGKEAGPC -------------------------------------------------------------- >9533_9533_6_BCR-RALGPS1_BCR_chr22_23615961_ENST00000359540_RALGPS1_chr9_129831507_ENST00000259351_length(amino acids)=1101AA_BP=705 MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGELLNRKDKTTFEKLDY LMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVR YIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVES KSATFPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFSEEMSSGLESPTGPCICSLGNSAAVPTMEGPLRRKTLLKE GRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHK -------------------------------------------------------------- >9533_9533_7_BCR-RALGPS1_BCR_chr22_23615961_ENST00000359540_RALGPS1_chr9_129831507_ENST00000373434_length(amino acids)=1073AA_BP=705 MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGELLNRKDKTTFEKLDY LMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVR YIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNRGRLYATLGP NWRVPVRNSPRTRSCVYSPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHVSIVGW -------------------------------------------------------------- >9533_9533_8_BCR-RALGPS1_BCR_chr22_23615961_ENST00000359540_RALGPS1_chr9_129831507_ENST00000373436_length(amino acids)=849AA_BP=705 MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGELLNRKDKTTFEKLDY LMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVR -------------------------------------------------------------- >9533_9533_9_BCR-RALGPS1_BCR_chr22_23615961_ENST00000359540_RALGPS1_chr9_129831507_ENST00000394022_length(amino acids)=928AA_BP=705 MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGELLNRKDKTTFEKLDY LMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVR YIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAVSHLSSLSHQGQAEEARLKPTSGQHPAWMWPSSSRVPAAPPASAAPRSPWPRN -------------------------------------------------------------- >9533_9533_10_BCR-RALGPS1_BCR_chr22_23615961_ENST00000359540_RALGPS1_chr9_129831507_ENST00000424082_length(amino acids)=1081AA_BP=705 MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGELLNRKDKTTFEKLDY LMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVR YIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNRGRLYATLGP NWRVPVRNSPRTRSCVYSPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPG KKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQEAGAAPGPTGTDSHEVDHLEGGAGKEAGPC -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:23615961/chr9:129831507) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BCR | . |
| FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000305877 | + | 8 | 23 | 498_691 | 705.0 | 1272.0 | Domain | DH |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000359540 | + | 8 | 22 | 498_691 | 705.0 | 1228.0 | Domain | DH |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000305877 | + | 8 | 23 | 197_385 | 705.0 | 1272.0 | Region | Note=Binding to ABL SH2-domain |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000305877 | + | 8 | 23 | 1_426 | 705.0 | 1272.0 | Region | Note=Kinase |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000359540 | + | 8 | 22 | 197_385 | 705.0 | 1228.0 | Region | Note=Binding to ABL SH2-domain |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000359540 | + | 8 | 22 | 1_426 | 705.0 | 1228.0 | Region | Note=Kinase |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000394011 | 0 | 5 | 21_26 | 0 | 109.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000259351 | 6 | 19 | 431_543 | 161.0 | 558.0 | Domain | PH | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000373434 | 5 | 17 | 431_543 | 161.0 | 530.0 | Domain | PH | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000373436 | 6 | 12 | 431_543 | 161.0 | 306.0 | Domain | PH | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000394011 | 0 | 5 | 431_543 | 0 | 109.0 | Domain | PH | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000394011 | 0 | 5 | 50_289 | 0 | 109.0 | Domain | Ras-GEF | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000394022 | 6 | 12 | 431_543 | 161.0 | 385.0 | Domain | PH | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000424082 | 6 | 18 | 431_543 | 161.0 | 538.0 | Domain | PH | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000259351 | 6 | 19 | 330_333 | 161.0 | 558.0 | Motif | Note=PXXP | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000373434 | 5 | 17 | 330_333 | 161.0 | 530.0 | Motif | Note=PXXP | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000373436 | 6 | 12 | 330_333 | 161.0 | 306.0 | Motif | Note=PXXP | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000394011 | 0 | 5 | 330_333 | 0 | 109.0 | Motif | Note=PXXP | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000394022 | 6 | 12 | 330_333 | 161.0 | 385.0 | Motif | Note=PXXP | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000424082 | 6 | 18 | 330_333 | 161.0 | 538.0 | Motif | Note=PXXP | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000259351 | 6 | 19 | 433_557 | 161.0 | 558.0 | Region | Note=Required for stimulation of nucleotide exchange by RALA | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000373434 | 5 | 17 | 433_557 | 161.0 | 530.0 | Region | Note=Required for stimulation of nucleotide exchange by RALA | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000373436 | 6 | 12 | 433_557 | 161.0 | 306.0 | Region | Note=Required for stimulation of nucleotide exchange by RALA | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000394011 | 0 | 5 | 433_557 | 0 | 109.0 | Region | Note=Required for stimulation of nucleotide exchange by RALA | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000394022 | 6 | 12 | 433_557 | 161.0 | 385.0 | Region | Note=Required for stimulation of nucleotide exchange by RALA | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000424082 | 6 | 18 | 433_557 | 161.0 | 538.0 | Region | Note=Required for stimulation of nucleotide exchange by RALA |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000305877 | + | 8 | 23 | 824_827 | 705.0 | 1272.0 | Compositional bias | Note=Poly-Leu |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000359540 | + | 8 | 22 | 824_827 | 705.0 | 1228.0 | Compositional bias | Note=Poly-Leu |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000305877 | + | 8 | 23 | 1054_1248 | 705.0 | 1272.0 | Domain | Rho-GAP |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000305877 | + | 8 | 23 | 708_866 | 705.0 | 1272.0 | Domain | PH |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000305877 | + | 8 | 23 | 893_1020 | 705.0 | 1272.0 | Domain | C2 |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000359540 | + | 8 | 22 | 1054_1248 | 705.0 | 1228.0 | Domain | Rho-GAP |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000359540 | + | 8 | 22 | 708_866 | 705.0 | 1228.0 | Domain | PH |
| Hgene | BCR | chr22:23615961 | chr9:129831507 | ENST00000359540 | + | 8 | 22 | 893_1020 | 705.0 | 1228.0 | Domain | C2 |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000259351 | 6 | 19 | 21_26 | 161.0 | 558.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000373434 | 5 | 17 | 21_26 | 161.0 | 530.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000373436 | 6 | 12 | 21_26 | 161.0 | 306.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000394022 | 6 | 12 | 21_26 | 161.0 | 385.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000424082 | 6 | 18 | 21_26 | 161.0 | 538.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000259351 | 6 | 19 | 50_289 | 161.0 | 558.0 | Domain | Ras-GEF | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000373434 | 5 | 17 | 50_289 | 161.0 | 530.0 | Domain | Ras-GEF | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000373436 | 6 | 12 | 50_289 | 161.0 | 306.0 | Domain | Ras-GEF | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000394022 | 6 | 12 | 50_289 | 161.0 | 385.0 | Domain | Ras-GEF | |
| Tgene | RALGPS1 | chr22:23615961 | chr9:129831507 | ENST00000424082 | 6 | 18 | 50_289 | 161.0 | 538.0 | Domain | Ras-GEF |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| BCR | MLLT4, HCK, PTPN6, FES, RB1, ERCC3, GRB2, ABL1, GAB2, HOXA9, CRKL, KIT, PIK3CG, IGSF21, TP53, UNC119, SOS1, PXN, RAC1, CDC42, RHOA, IL3, WDR48, TSG101, VPS28, INPP5D, MYC, HSP90AA1, HSPA8, HIF1A, CRK, GABRR1, CBL, LNX1, LRRK1, GRK5, UBASH3B, PIK3R2, SHC1, AP2M1, Grasp, CFTR, ERBB2IP, DOK1, PTGES3, HSPA4, HSPD1, UBC, CSNK2A2, STUB1, CCDC183, RSPH9, SEC13, Numb, NTRK1, CEP128, NINL, XPO1, Scai, PIK3R1, PDZK1, COMMD1, TULP3, JPH4, NAGK, USP15, SPAG9, MCM2, MCM4, WEE1, CSNK1A1, MCM6, TRIM25, RAD51, HNRNPL, EGLN3, ESR2, DPF2, RECQL4, EZR, KIAA1429, SCAI, HOOK3, PTPN3, PLK1, PLEKHA4, nsp12, nsp15, nsp2, ARHGEF39, HSCB, SAMD4B, SMG6, BRPF3, CECR2, SP110, TRIM66, AP2A1, CSNK2A1, DDX58, USP1, ACTR1A, ANK3, AP2B1, CEP135, CLTA, CTNNA1, DCTN2, MAPRE3, PFN1, RAB2A, RDX, RHOB, SQSTM1, VASP, ATG7, ATG10, ATG3, MAP4K1, NUDCD2, VPS33A, PSD4, SLA2, AGO4, DDR1, YWHAB, NAA10, YWHAH, YWHAG, SURF6, SYNC, CSNK2B, BACE2, GRAP2, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| BCR |  |
| RALGPS1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to BCR-RALGPS1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to BCR-RALGPS1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BCR | C0005586 | Bipolar Disorder | 4 | PSYGENET |
| Hgene | BCR | C0023473 | Myeloid Leukemia, Chronic | 3 | CTD_human;ORPHANET |
| Hgene | BCR | C0005699 | Blast Phase | 1 | CTD_human |
| Hgene | BCR | C0006413 | Burkitt Lymphoma | 1 | ORPHANET |
| Hgene | BCR | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | BCR | C0027022 | Myeloproliferative disease | 1 | CTD_human |
| Hgene | BCR | C0027540 | Necrosis | 1 | CTD_human |
| Hgene | BCR | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
| Hgene | BCR | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | BCR | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Hgene | BCR | C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | ORPHANET |
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