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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TUFT1-KMT2E

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TUFT1-KMT2E
FusionPDB ID: 95434
FusionGDB2.0 ID: 95435
HgeneTgene
Gene symbol

TUFT1

KMT2E

Gene ID

7286

55904

Gene nametuftelin 1lysine methyltransferase 2E (inactive)
Synonyms-HDCMC04P|MLL5|NKp44L|ODLURO
Cytomap

1q21.3

7q22.3

Type of geneprotein-codingprotein-coding
Descriptiontuftelininactive histone-lysine N-methyltransferase 2Ehistone-lysine N-methyltransferase 2Ehistone-lysine N-methyltransferase MLL5inactive lysine N-methyltransferase 2Elysine (K)-specific methyltransferase 2Emyeloid/lymphoid or mixed-lineage leukemia 5 (trit
Modification date2020031320200314
UniProtAcc.

Q8IZD2

Ensembl transtripts involved in fusion geneENST idsENST00000353024, ENST00000368848, 
ENST00000368849, ENST00000392712, 
ENST00000538902, 		ENST00000476671, 
ENST00000480368, ENST00000257745, 
ENST00000311117, ENST00000334877, 
ENST00000334914, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 6 X 10=6007 X 10 X 3=210
# samples 1310
** MAII scorelog2(13/600*10)=-2.20645087746743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TUFT1 [Title/Abstract] AND KMT2E [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KMT2E(104748372)-TUFT1(151542133), # samples:1
TUFT1(151538704)-KMT2E(104749389), # samples:1
Anticipated loss of major functional domain due to fusion event.TUFT1-KMT2E seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TUFT1-KMT2E seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TUFT1-KMT2E seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TUFT1-KMT2E seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2E-TUFT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2E-TUFT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TUFT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KMT2E (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-A6-5660-01ATUFT1chr1

151538704

+KMT2Echr7

104749389

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000353024TUFT1chr1151538704+ENST00000311117KMT2Echr7104749389+3226365442473809
ENST00000353024TUFT1chr1151538704+ENST00000334914KMT2Echr7104749389+1502365441501486
ENST00000353024TUFT1chr1151538704+ENST00000257745KMT2Echr7104749389+3225365442473809
ENST00000353024TUFT1chr1151538704+ENST00000334877KMT2Echr7104749389+3376365442347767
ENST00000392712TUFT1chr1151538704+ENST00000311117KMT2Echr7104749389+3238377442485813
ENST00000392712TUFT1chr1151538704+ENST00000334914KMT2Echr7104749389+1514377441513490
ENST00000392712TUFT1chr1151538704+ENST00000257745KMT2Echr7104749389+3237377442485813
ENST00000392712TUFT1chr1151538704+ENST00000334877KMT2Echr7104749389+3388377442359771
ENST00000368849TUFT1chr1151538704+ENST00000311117KMT2Echr7104749389+3403542442650868
ENST00000368849TUFT1chr1151538704+ENST00000334914KMT2Echr7104749389+1679542441678545
ENST00000368849TUFT1chr1151538704+ENST00000257745KMT2Echr7104749389+3402542442650868
ENST00000368849TUFT1chr1151538704+ENST00000334877KMT2Echr7104749389+3553542442524826
ENST00000368848TUFT1chr1151538704+ENST00000311117KMT2Echr7104749389+3325464412572843
ENST00000368848TUFT1chr1151538704+ENST00000334914KMT2Echr7104749389+1601464411600520
ENST00000368848TUFT1chr1151538704+ENST00000257745KMT2Echr7104749389+3324464412572843
ENST00000368848TUFT1chr1151538704+ENST00000334877KMT2Echr7104749389+3475464412446801
ENST00000538902TUFT1chr1151538704+ENST00000311117KMT2Echr7104749389+35386771342785883
ENST00000538902TUFT1chr1151538704+ENST00000334914KMT2Echr7104749389+18146771341813560
ENST00000538902TUFT1chr1151538704+ENST00000257745KMT2Echr7104749389+35376771342785883
ENST00000538902TUFT1chr1151538704+ENST00000334877KMT2Echr7104749389+36886771342659841

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000353024ENST00000311117TUFT1chr1151538704+KMT2Echr7104749389+0.0028688980.9971311
ENST00000353024ENST00000334914TUFT1chr1151538704+KMT2Echr7104749389+0.0055005160.99449944
ENST00000353024ENST00000257745TUFT1chr1151538704+KMT2Echr7104749389+0.0029163340.9970836
ENST00000353024ENST00000334877TUFT1chr1151538704+KMT2Echr7104749389+0.002771510.99722844
ENST00000392712ENST00000311117TUFT1chr1151538704+KMT2Echr7104749389+0.0042157460.9957842
ENST00000392712ENST00000334914TUFT1chr1151538704+KMT2Echr7104749389+0.0070653840.99293464
ENST00000392712ENST00000257745TUFT1chr1151538704+KMT2Echr7104749389+0.0042720440.99572796
ENST00000392712ENST00000334877TUFT1chr1151538704+KMT2Echr7104749389+0.003580330.99641967
ENST00000368849ENST00000311117TUFT1chr1151538704+KMT2Echr7104749389+0.0032106690.99678934
ENST00000368849ENST00000334914TUFT1chr1151538704+KMT2Echr7104749389+0.0111544170.9888455
ENST00000368849ENST00000257745TUFT1chr1151538704+KMT2Echr7104749389+0.003254460.99674547
ENST00000368849ENST00000334877TUFT1chr1151538704+KMT2Echr7104749389+0.0033585350.9966415
ENST00000368848ENST00000311117TUFT1chr1151538704+KMT2Echr7104749389+0.0062377880.9937622
ENST00000368848ENST00000334914TUFT1chr1151538704+KMT2Echr7104749389+0.0172550860.9827449
ENST00000368848ENST00000257745TUFT1chr1151538704+KMT2Echr7104749389+0.006299280.99370074
ENST00000368848ENST00000334877TUFT1chr1151538704+KMT2Echr7104749389+0.0052663870.9947336
ENST00000538902ENST00000311117TUFT1chr1151538704+KMT2Echr7104749389+0.0042994930.99570054
ENST00000538902ENST00000334914TUFT1chr1151538704+KMT2Echr7104749389+0.0210145450.9789854
ENST00000538902ENST00000257745TUFT1chr1151538704+KMT2Echr7104749389+0.0043404470.99565953
ENST00000538902ENST00000334877TUFT1chr1151538704+KMT2Echr7104749389+0.0045164510.9954835

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>95434_95434_1_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000353024_KMT2E_chr7_104749389_ENST00000257745_length(amino acids)=809AA_BP=107
MRPRGKMNGTRNWCTLVDVHPEDQAAVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEK
PNGFSQSPTALYSSPPEVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSE
ETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFS
ELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQ
ALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNF
YPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQA
LPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPP
PPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHT

--------------------------------------------------------------

>95434_95434_2_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000353024_KMT2E_chr7_104749389_ENST00000311117_length(amino acids)=809AA_BP=107
MRPRGKMNGTRNWCTLVDVHPEDQAAVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEK
PNGFSQSPTALYSSPPEVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSE
ETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFS
ELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQ
ALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNF
YPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQA
LPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPP
PPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHT

--------------------------------------------------------------

>95434_95434_3_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000353024_KMT2E_chr7_104749389_ENST00000334877_length(amino acids)=767AA_BP=107
MRPRGKMNGTRNWCTLVDVHPEDQAAVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEK
PNGFSQSPTALYSSPPEVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSE
ETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPG
SVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPP
KSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNS
TAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPP
PPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPP
PPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGF

--------------------------------------------------------------

>95434_95434_4_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000353024_KMT2E_chr7_104749389_ENST00000334914_length(amino acids)=486AA_BP=107
MRPRGKMNGTRNWCTLVDVHPEDQAAVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEK
PNGFSQSPTALYSSPPEVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSE
ETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFS
ELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQ
ALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNF

--------------------------------------------------------------

>95434_95434_5_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000368848_KMT2E_chr7_104749389_ENST00000257745_length(amino acids)=843AA_BP=141
MRPRGKMNGTRNWCTLVDVHPEDQAAAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEA
RNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNN
GDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGES
PCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTK
PDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYL
SPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSS
YYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPN
SHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTS
AQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQ

--------------------------------------------------------------

>95434_95434_6_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000368848_KMT2E_chr7_104749389_ENST00000311117_length(amino acids)=843AA_BP=141
MRPRGKMNGTRNWCTLVDVHPEDQAAAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEA
RNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNN
GDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGES
PCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTK
PDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYL
SPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSS
YYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPN
SHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTS
AQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQ

--------------------------------------------------------------

>95434_95434_7_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000368848_KMT2E_chr7_104749389_ENST00000334877_length(amino acids)=801AA_BP=141
MRPRGKMNGTRNWCTLVDVHPEDQAAAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEA
RNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNN
GDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSDPDP
ENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPP
QTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLP
ANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQ
TVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPA
PHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQH

--------------------------------------------------------------

>95434_95434_8_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000368848_KMT2E_chr7_104749389_ENST00000334914_length(amino acids)=520AA_BP=141
MRPRGKMNGTRNWCTLVDVHPEDQAAAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEA
RNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNN
GDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGES
PCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTK
PDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYL

--------------------------------------------------------------

>95434_95434_9_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000368849_KMT2E_chr7_104749389_ENST00000257745_length(amino acids)=868AA_BP=166
MRPRGKMNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKG
RSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVSLLEYRKRQREAR
KSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQ
VRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKS
PPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLH
CPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSAT
YSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQ
TAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHV
VNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGP

--------------------------------------------------------------

>95434_95434_10_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000368849_KMT2E_chr7_104749389_ENST00000311117_length(amino acids)=868AA_BP=166
MRPRGKMNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKG
RSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVSLLEYRKRQREAR
KSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQ
VRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKS
PPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLH
CPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSAT
YSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQ
TAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHV
VNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGP

--------------------------------------------------------------

>95434_95434_11_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000368849_KMT2E_chr7_104749389_ENST00000334877_length(amino acids)=826AA_BP=166
MRPRGKMNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKG
RSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVSLLEYRKRQREAR
KSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQ
VRERSYQRALLLSDHRKDKDSDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENG
VHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHH
SQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQL
KGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAV
TPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPS
SAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRA

--------------------------------------------------------------

>95434_95434_12_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000368849_KMT2E_chr7_104749389_ENST00000334914_length(amino acids)=545AA_BP=166
MRPRGKMNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKG
RSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVSLLEYRKRQREAR
KSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQ
VRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKS
PPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLH
CPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSAT

--------------------------------------------------------------

>95434_95434_13_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000392712_KMT2E_chr7_104749389_ENST00000257745_length(amino acids)=813AA_BP=111
MRPRGKMNGTRNWCTLVDVHPEDQAAAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEV
VLEKPNGFSQSPTALYSSPPEVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYN
ATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPV
PSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLS
NNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREP
QRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSG
PNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGH
HLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQA
THHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGS

--------------------------------------------------------------

>95434_95434_14_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000392712_KMT2E_chr7_104749389_ENST00000311117_length(amino acids)=813AA_BP=111
MRPRGKMNGTRNWCTLVDVHPEDQAAAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEV
VLEKPNGFSQSPTALYSSPPEVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYN
ATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPV
PSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLS
NNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREP
QRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSG
PNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGH
HLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQA
THHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGS

--------------------------------------------------------------

>95434_95434_15_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000392712_KMT2E_chr7_104749389_ENST00000334877_length(amino acids)=771AA_BP=111
MRPRGKMNGTRNWCTLVDVHPEDQAAAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEV
VLEKPNGFSQSPTALYSSPPEVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYN
ATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKP
GSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHL
ENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQ
SLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVP
PPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPP
PPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPT

--------------------------------------------------------------

>95434_95434_16_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000392712_KMT2E_chr7_104749389_ENST00000334914_length(amino acids)=490AA_BP=111
MRPRGKMNGTRNWCTLVDVHPEDQAAAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEV
VLEKPNGFSQSPTALYSSPPEVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYN
ATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPV
PSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLS
NNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREP

--------------------------------------------------------------

>95434_95434_17_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000538902_KMT2E_chr7_104749389_ENST00000257745_length(amino acids)=883AA_BP=181
MRMSSPGMTSLQLEKEECMQCVPCSPRTRVALLELYRAMCQGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSLASELVE
SHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPP
EVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEK
NEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTT
NECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSS
EQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATS
GTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVT
PGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPH
PSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPH

--------------------------------------------------------------

>95434_95434_18_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000538902_KMT2E_chr7_104749389_ENST00000311117_length(amino acids)=883AA_BP=181
MRMSSPGMTSLQLEKEECMQCVPCSPRTRVALLELYRAMCQGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSLASELVE
SHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPP
EVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEK
NEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTT
NECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSS
EQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATS
GTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVT
PGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPH
PSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPH

--------------------------------------------------------------

>95434_95434_19_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000538902_KMT2E_chr7_104749389_ENST00000334877_length(amino acids)=841AA_BP=181
MRMSSPGMTSLQLEKEECMQCVPCSPRTRVALLELYRAMCQGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSLASELVE
SHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPP
EVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEK
NEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPD
PQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSP
KPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYY
QNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSH
QQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQ
ALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGP

--------------------------------------------------------------

>95434_95434_20_TUFT1-KMT2E_TUFT1_chr1_151538704_ENST00000538902_KMT2E_chr7_104749389_ENST00000334914_length(amino acids)=560AA_BP=181
MRMSSPGMTSLQLEKEECMQCVPCSPRTRVALLELYRAMCQGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSLASELVE
SHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPP
EVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEK
NEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTT
NECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSS
EQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:104748372/chr7:151542133)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KMT2E

Q8IZD2

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:24130829, PubMed:23798402). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:24130829, PubMed:23798402). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTUFT1chr1:151538704chr7:104749389ENST00000368848+51288_126135.0366.0Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151538704chr7:104749389ENST00000368849+61388_126160.0391.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Echr1:151538704chr7:104749389ENST00000476671015559_6150610.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Echr1:151538704chr7:104749389ENST0000025774520261433_18461156.01859.0Compositional biasPro-rich
TgeneKMT2Echr1:151538704chr7:104749389ENST0000031111721271433_18461156.01859.0Compositional biasPro-rich
TgeneKMT2Echr1:151538704chr7:104749389ENST0000033487721261433_18461156.01817.0Compositional biasPro-rich
TgeneKMT2Echr1:151538704chr7:104749389ENST000004766710151433_18460610.0Compositional biasPro-rich
TgeneKMT2Echr1:151538704chr7:104749389ENST00000476671015330_4470610.0DomainSET
TgeneKMT2Echr1:151538704chr7:104749389ENST00000476671015118_1660610.0Zinc fingerPHD-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTUFT1chr1:151538704chr7:104749389ENST00000353024+411162_351101.0332.0Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151538704chr7:104749389ENST00000353024+41188_126101.0332.0Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151538704chr7:104749389ENST00000368848+512162_351135.0366.0Coiled coilOntology_term=ECO:0000255
HgeneTUFT1chr1:151538704chr7:104749389ENST00000368849+613162_351160.0391.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Echr1:151538704chr7:104749389ENST000002577452026559_6151156.01859.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Echr1:151538704chr7:104749389ENST000003111172127559_6151156.01859.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Echr1:151538704chr7:104749389ENST000003348772126559_6151156.01817.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Echr1:151538704chr7:104749389ENST000002577452026330_4471156.01859.0DomainSET
TgeneKMT2Echr1:151538704chr7:104749389ENST000003111172127330_4471156.01859.0DomainSET
TgeneKMT2Echr1:151538704chr7:104749389ENST000003348772126330_4471156.01817.0DomainSET
TgeneKMT2Echr1:151538704chr7:104749389ENST000002577452026118_1661156.01859.0Zinc fingerPHD-type
TgeneKMT2Echr1:151538704chr7:104749389ENST000003111172127118_1661156.01859.0Zinc fingerPHD-type
TgeneKMT2Echr1:151538704chr7:104749389ENST000003348772126118_1661156.01817.0Zinc fingerPHD-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TUFT1
KMT2E


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TUFT1-KMT2E


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TUFT1-KMT2E


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource