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Fusion Protein:TXNRD1-LAMTOR3 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: TXNRD1-LAMTOR3 | FusionPDB ID: 95621 | FusionGDB2.0 ID: 95621 | Hgene | Tgene | Gene symbol | TXNRD1 | LAMTOR3 | Gene ID | 7296 | 8649 |
| Gene name | thioredoxin reductase 1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 | |
| Synonyms | GRIM-12|TR|TR1|TRXR1|TXNR | MAP2K1IP1|MAPBP|MAPKSP1|MP1|PRO0633|Ragulator3 | |
| Cytomap | 12q23.3 | 4q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thioredoxin reductase 1, cytoplasmicKM-102-derived reductase-like factorgene associated with retinoic and IFN-induced mortality 12 proteingene associated with retinoic and interferon-induced mortality 12 proteinoxidoreductasetestis tissue sperm-bindi | ragulator complex protein LAMTOR3MAPK scaffold protein 1MEK binding partner 1late endosomal/lysosomal adaptor and MAPK and MTOR activator 3mitogen-activated protein kinase kinase 1 interacting protein 1mitogen-activated protein kinase scaffold protei | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q9UHA4 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000354940, ENST00000378070, ENST00000388854, ENST00000397736, ENST00000427956, ENST00000429002, ENST00000503506, ENST00000524698, ENST00000525566, ENST00000526390, ENST00000526691, ENST00000526950, ENST00000529546, ENST00000540716, ENST00000542918, ENST00000526006, | ENST00000515100, ENST00000226522, ENST00000499666, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 30 X 25 X 8=6000 | 3 X 3 X 3=27 |
| # samples | 37 | 3 | |
| ** MAII score | log2(37/6000*10)=-4.01936532486693 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: TXNRD1 [Title/Abstract] AND LAMTOR3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TXNRD1(104707095)-LAMTOR3(100803224), # samples:4 | ||
| Anticipated loss of major functional domain due to fusion event. | TXNRD1-LAMTOR3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TXNRD1-LAMTOR3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TXNRD1-LAMTOR3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TXNRD1-LAMTOR3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across TXNRD1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across LAMTOR3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-98-A53A-01A | TXNRD1 | chr12 | 104707095 | - | LAMTOR3 | chr4 | 100803224 | - |
| ChimerDB4 | LUSC | TCGA-98-A53A-01A | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - |
| ChimerDB4 | LUSC | TCGA-98-A53A | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000525566 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4366 | 634 | 15 | 707 | 230 |
| ENST00000525566 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1495 | 634 | 15 | 707 | 230 |
| ENST00000429002 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4364 | 632 | 13 | 705 | 230 |
| ENST00000429002 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1493 | 632 | 13 | 705 | 230 |
| ENST00000503506 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4466 | 734 | 442 | 807 | 121 |
| ENST00000503506 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1595 | 734 | 442 | 807 | 121 |
| ENST00000526691 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4504 | 772 | 297 | 845 | 182 |
| ENST00000526691 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1633 | 772 | 297 | 845 | 182 |
| ENST00000388854 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4436 | 704 | 229 | 777 | 182 |
| ENST00000388854 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1565 | 704 | 229 | 777 | 182 |
| ENST00000354940 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4326 | 594 | 2953 | 2627 | 108 |
| ENST00000354940 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1455 | 594 | 389 | 81 | 102 |
| ENST00000526390 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4347 | 615 | 257 | 688 | 143 |
| ENST00000526390 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1476 | 615 | 257 | 688 | 143 |
| ENST00000529546 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4003 | 271 | 2630 | 2304 | 108 |
| ENST00000529546 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1132 | 271 | 20 | 265 | 81 |
| ENST00000540716 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 3993 | 261 | 2620 | 2294 | 108 |
| ENST00000540716 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1122 | 261 | 10 | 255 | 81 |
| ENST00000524698 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4102 | 370 | 3 | 443 | 146 |
| ENST00000524698 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1231 | 370 | 3 | 443 | 146 |
| ENST00000542918 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4102 | 370 | 3 | 443 | 146 |
| ENST00000542918 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1231 | 370 | 3 | 443 | 146 |
| ENST00000378070 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4251 | 519 | 53 | 592 | 179 |
| ENST00000378070 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1380 | 519 | 53 | 592 | 179 |
| ENST00000397736 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4024 | 292 | 0 | 365 | 121 |
| ENST00000397736 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1153 | 292 | 0 | 365 | 121 |
| ENST00000427956 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4237 | 505 | 0 | 578 | 192 |
| ENST00000427956 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1366 | 505 | 0 | 578 | 192 |
| ENST00000526950 | TXNRD1 | chr12 | 104707095 | + | ENST00000499666 | LAMTOR3 | chr4 | 100803224 | - | 4177 | 445 | 78 | 518 | 146 |
| ENST00000526950 | TXNRD1 | chr12 | 104707095 | + | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | 1306 | 445 | 78 | 518 | 146 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000525566 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.00201076 | 0.9979893 |
| ENST00000525566 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.001404364 | 0.99859565 |
| ENST00000429002 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.002021804 | 0.99797827 |
| ENST00000429002 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.001408643 | 0.99859136 |
| ENST00000503506 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.17479376 | 0.8252063 |
| ENST00000503506 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.09180339 | 0.9081966 |
| ENST00000526691 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.016437171 | 0.9835629 |
| ENST00000526691 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.010647613 | 0.9893524 |
| ENST00000388854 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.016957682 | 0.98304236 |
| ENST00000388854 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.007574997 | 0.99242496 |
| ENST00000354940 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.1865999 | 0.8134001 |
| ENST00000354940 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.101772204 | 0.8982278 |
| ENST00000526390 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.021847187 | 0.9781528 |
| ENST00000526390 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.016204339 | 0.98379564 |
| ENST00000529546 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.94694126 | 0.053058773 |
| ENST00000529546 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.75456053 | 0.24543948 |
| ENST00000540716 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.94725007 | 0.052749928 |
| ENST00000540716 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.7862155 | 0.21378449 |
| ENST00000524698 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.013083735 | 0.9869163 |
| ENST00000524698 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.004432951 | 0.995567 |
| ENST00000542918 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.013083735 | 0.9869163 |
| ENST00000542918 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.004432951 | 0.995567 |
| ENST00000378070 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.005958981 | 0.994041 |
| ENST00000378070 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.004338722 | 0.9956613 |
| ENST00000397736 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.022922374 | 0.9770776 |
| ENST00000397736 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.01567156 | 0.9843284 |
| ENST00000427956 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.012663405 | 0.9873366 |
| ENST00000427956 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.008984164 | 0.9910158 |
| ENST00000526950 | ENST00000499666 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.016176047 | 0.9838239 |
| ENST00000526950 | ENST00000226522 | TXNRD1 | chr12 | 104707095 | + | LAMTOR3 | chr4 | 100803224 | - | 0.009979057 | 0.990021 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >95621_95621_1_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000354940_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=102AA_BP= MLKLCVTGSKPHTPRSCLGLEKPPRLLRHALKYLPFPETHTAAPRRNAVVPAGRPSPACSHPWARGFVWFHPTQSLQEFENDEDIRPSFR -------------------------------------------------------------- >95621_95621_2_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000354940_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=108AA_BP= MTGTPDGIAYYYTPRLYGIAYYYIPRLYGIAYYTPRLYGIAYYYTPRLYGIAYYYTPRLYGIAYYYTPRLYGIAYYYTPRLYGIAYYTPR -------------------------------------------------------------- >95621_95621_3_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000378070_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=179AA_BP=155 MSEMQQVMLTCKGVNRGHAVPAGPGRKPRPRRSSRLLAGEKHLTRSALLLCHTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLK -------------------------------------------------------------- >95621_95621_4_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000378070_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=179AA_BP=155 MSEMQQVMLTCKGVNRGHAVPAGPGRKPRPRRSSRLLAGEKHLTRSALLLCHTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLK -------------------------------------------------------------- >95621_95621_5_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000388854_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=182AA_BP=158 MPAGTTALRLGAAVCVSGKGRYFKACLSRRGGFSKPRQLRGVCGFDPVTQSFSMSCEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGP TLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLIVSLEKELAPLFEELRQVVE -------------------------------------------------------------- >95621_95621_6_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000388854_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=182AA_BP=158 MPAGTTALRLGAAVCVSGKGRYFKACLSRRGGFSKPRQLRGVCGFDPVTQSFSMSCEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGP TLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLIVSLEKELAPLFEELRQVVE -------------------------------------------------------------- >95621_95621_7_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000397736_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=121AA_BP=97 MLSRLVLNSWAQAIIRPRPPKVLGLQVTTFSEAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTP -------------------------------------------------------------- >95621_95621_8_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000397736_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=121AA_BP=97 MLSRLVLNSWAQAIIRPRPPKVLGLQVTTFSEAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTP -------------------------------------------------------------- >95621_95621_9_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000427956_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=192AA_BP=168 MPVDDYWLCLPASCARPFVQTVRVVQSCPHCCWFPGVLPSVPEPLRMPAMLPTGSHSAVLPPSHCSTAPPSTSQEPSSSADPKLCLSPPT SDSRQERNVQFGLAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLIVSLEKELAP -------------------------------------------------------------- >95621_95621_10_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000427956_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=192AA_BP=168 MPVDDYWLCLPASCARPFVQTVRVVQSCPHCCWFPGVLPSVPEPLRMPAMLPTGSHSAVLPPSHCSTAPPSTSQEPSSSADPKLCLSPPT SDSRQERNVQFGLAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLIVSLEKELAP -------------------------------------------------------------- >95621_95621_11_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000429002_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=230AA_BP=206 MCDMGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQAYIDGHSVVIFSRSTCTRCTEVKKLFK SLCVPYFVLELDQTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAA -------------------------------------------------------------- >95621_95621_12_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000429002_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=230AA_BP=206 MCDMGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQAYIDGHSVVIFSRSTCTRCTEVKKLFK SLCVPYFVLELDQTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAA -------------------------------------------------------------- >95621_95621_13_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000503506_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=121AA_BP=97 MEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTP -------------------------------------------------------------- >95621_95621_14_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000503506_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=121AA_BP=97 MEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTP -------------------------------------------------------------- >95621_95621_15_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000524698_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=146AA_BP=122 MAVSFLLVFVETVCRTAEKMEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGG -------------------------------------------------------------- >95621_95621_16_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000524698_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=146AA_BP=122 MAVSFLLVFVETVCRTAEKMEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGG -------------------------------------------------------------- >95621_95621_17_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000525566_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=230AA_BP=206 MCDMGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQAYIDGHSVVIFSRSTCTRCTEVKKLFK SLCVPYFVLELDQTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAA -------------------------------------------------------------- >95621_95621_18_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000525566_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=230AA_BP=206 MCDMGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQAYIDGHSVVIFSRSTCTRCTEVKKLFK SLCVPYFVLELDQTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAA -------------------------------------------------------------- >95621_95621_19_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000526390_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=143AA_BP=119 MEESNQEALGVTSFSFRDGGLIMLSRLVLNSWAQAIIRPRPPKVLGLQVTTFSEAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGG -------------------------------------------------------------- >95621_95621_20_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000526390_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=143AA_BP=119 MEESNQEALGVTSFSFRDGGLIMLSRLVLNSWAQAIIRPRPPKVLGLQVTTFSEAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGG -------------------------------------------------------------- >95621_95621_21_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000526691_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=182AA_BP=158 MPAGTTALRLGAAVCVSGKGRYFKACLSRRGGFSKPRQLRGVCGFDPVTQSFSMSCEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGP TLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLIVSLEKELAPLFEELRQVVE -------------------------------------------------------------- >95621_95621_22_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000526691_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=182AA_BP=158 MPAGTTALRLGAAVCVSGKGRYFKACLSRRGGFSKPRQLRGVCGFDPVTQSFSMSCEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGP TLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLIVSLEKELAPLFEELRQVVE -------------------------------------------------------------- >95621_95621_23_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000526950_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=146AA_BP=122 MPAMLPTGSHSAVLPPSHCSTAPPSTSQEPSSSADPKLCLSPPTSDSRQERNVQFGLAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGG -------------------------------------------------------------- >95621_95621_24_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000526950_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=146AA_BP=122 MPAMLPTGSHSAVLPPSHCSTAPPSTSQEPSSSADPKLCLSPPTSDSRQERNVQFGLAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGG -------------------------------------------------------------- >95621_95621_25_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000529546_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=81AA_BP= -------------------------------------------------------------- >95621_95621_26_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000529546_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=108AA_BP= MTGTPDGIAYYYTPRLYGIAYYYIPRLYGIAYYTPRLYGIAYYYTPRLYGIAYYYTPRLYGIAYYYTPRLYGIAYYYTPRLYGIAYYTPR -------------------------------------------------------------- >95621_95621_27_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000540716_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=81AA_BP= -------------------------------------------------------------- >95621_95621_28_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000540716_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=108AA_BP= MTGTPDGIAYYYTPRLYGIAYYYIPRLYGIAYYTPRLYGIAYYYTPRLYGIAYYYTPRLYGIAYYYTPRLYGIAYYYTPRLYGIAYYTPR -------------------------------------------------------------- >95621_95621_29_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000542918_LAMTOR3_chr4_100803224_ENST00000226522_length(amino acids)=146AA_BP=122 MAVSFLLVFVETVCRTAEKMEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGG -------------------------------------------------------------- >95621_95621_30_TXNRD1-LAMTOR3_TXNRD1_chr12_104707095_ENST00000542918_LAMTOR3_chr4_100803224_ENST00000499666_length(amino acids)=146AA_BP=122 MAVSFLLVFVETVCRTAEKMEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGG -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:104707095/chr4:100803224) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | LAMTOR3 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TXNRD1 | chr12:104707095 | chr4:100803224 | ENST00000525566 | + | 6 | 17 | 56_156 | 203.33333333333334 | 650.0 | Domain | Glutaredoxin |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TXNRD1 | chr12:104707095 | chr4:100803224 | ENST00000388854 | + | 4 | 15 | 56_156 | 105.33333333333333 | 550.0 | Domain | Glutaredoxin |
| Hgene | TXNRD1 | chr12:104707095 | chr4:100803224 | ENST00000503506 | + | 4 | 15 | 56_156 | 53.333333333333336 | 500.0 | Domain | Glutaredoxin |
| Hgene | TXNRD1 | chr12:104707095 | chr4:100803224 | ENST00000524698 | + | 4 | 15 | 56_156 | 53.333333333333336 | 500.0 | Domain | Glutaredoxin |
| Hgene | TXNRD1 | chr12:104707095 | chr4:100803224 | ENST00000526390 | + | 6 | 17 | 56_156 | 97.33333333333333 | 544.0 | Domain | Glutaredoxin |
| Hgene | TXNRD1 | chr12:104707095 | chr4:100803224 | ENST00000526691 | + | 4 | 15 | 56_156 | 105.33333333333333 | 552.0 | Domain | Glutaredoxin |
| Hgene | TXNRD1 | chr12:104707095 | chr4:100803224 | ENST00000388854 | + | 4 | 15 | 192_209 | 105.33333333333333 | 550.0 | Nucleotide binding | FAD |
| Hgene | TXNRD1 | chr12:104707095 | chr4:100803224 | ENST00000503506 | + | 4 | 15 | 192_209 | 53.333333333333336 | 500.0 | Nucleotide binding | FAD |
| Hgene | TXNRD1 | chr12:104707095 | chr4:100803224 | ENST00000524698 | + | 4 | 15 | 192_209 | 53.333333333333336 | 500.0 | Nucleotide binding | FAD |
| Hgene | TXNRD1 | chr12:104707095 | chr4:100803224 | ENST00000525566 | + | 6 | 17 | 192_209 | 203.33333333333334 | 650.0 | Nucleotide binding | FAD |
| Hgene | TXNRD1 | chr12:104707095 | chr4:100803224 | ENST00000526390 | + | 6 | 17 | 192_209 | 97.33333333333333 | 544.0 | Nucleotide binding | FAD |
| Hgene | TXNRD1 | chr12:104707095 | chr4:100803224 | ENST00000526691 | + | 4 | 15 | 192_209 | 105.33333333333333 | 552.0 | Nucleotide binding | FAD |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
| PDB file >>>350_TXNRD1_104707095_LAMTOR3_100803224_ranked_0.pdb | TXNRD1 | 104707095 | 104707095 | ENST00000226522 | LAMTOR3 | chr4 | 100803224 | - | MCDMGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQAYIDGHSVVIFSRSTCTRCTEVKKLFK SLCVPYFVLELDQTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAA | 230 |
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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LAMTOR3_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| TXNRD1 | |
| LAMTOR3 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to TXNRD1-LAMTOR3 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to TXNRD1-LAMTOR3 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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