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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:BDP1-KDM5A

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: BDP1-KDM5A
	FusionPDB ID: 9568
	FusionGDB2.0 ID: 9568
		Hgene	Tgene
	Gene symbol	BDP1	KDM5A
	Gene ID	55814	5927
	Gene name	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	lysine demethylase 5A
	Synonyms	DFNB112\|HSA238520\|TAF3B1\|TFC5\|TFIIIB''\|TFIIIB150\|TFIIIB90\|TFNR	RBBP-2\|RBBP2\|RBP2
	Cytomap	5q13.2	12p13.33
	Type of gene	protein-coding	protein-coding
	Description	transcription factor TFIIIB component B'' homologRNA polymerase III transcription initiation factor B''TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1transcription factor IIIB 150transcription factor-like nuclear	lysine-specific demethylase 5AJumonji, AT rich interactive domain 1A (RBP2-like)histone demethylase JARID1Ajumonji/ARID domain-containing protein 1Alysine (K)-specific demethylase 5Aretinoblastoma binding protein 2
	Modification date	20200313	20200313
	UniProtAcc	A6H8Y1	P29375
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000358731, ENST00000380675,	ENST00000382815, ENST00000540838, ENST00000399788,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 8 X 5=320	10 X 11 X 4=440
	# samples	9	10
	** MAII score	log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/440*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: BDP1 [Title/Abstract] AND KDM5A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	BDP1(70811993)-KDM5A(402303), # samples:2
Anticipated loss of major functional domain due to fusion event.	BDP1-KDM5A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BDP1-KDM5A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BDP1-KDM5A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BDP1-KDM5A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	KDM5A	GO:0034720	histone H3-K4 demethylation	18270511
Tgene	KDM5A	GO:0045893	positive regulation of transcription, DNA-templated	11358960

Fusion gene breakpoints across BDP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KDM5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CB119428	BDP1	chr5	70811993	+	KDM5A	chr12	402303	-
ChiTaRS5.0	N/A	CB119529	BDP1	chr5	70811993	+	KDM5A	chr12	402303	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000358731

BDP1

chr5

70811993

ENST00000399788

KDM5A

chr12

402303

10930

5017

263

4930

1555

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000358731	ENST00000399788	BDP1	chr5	70811993	+	KDM5A	chr12	402303	-	0.000142348	0.99985766

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>9568_9568_1_BDP1-KDM5A_BDP1_chr5_70811993_ENST00000358731_KDM5A_chr12_402303_ENST00000399788_length(amino acids)=1555AA_BP=
MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSST
VSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPD
RSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRT
KGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKR
PFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDA
EQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRT
DPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKS
VLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAE
RKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTR
FQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMET
GLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRR
KISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEV
IDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEME
TDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKR
DIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSL
DIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKR
PKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:70811993/chr12:402303)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BDP1 A6H8Y1	KDM5A P29375
FUNCTION: General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269\|PubMed:11040218}.	FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250\|UniProtKB:Q3UXZ9, ECO:0000269\|PubMed:11358960, ECO:0000269\|PubMed:15949438, ECO:0000269\|PubMed:17320160, ECO:0000269\|PubMed:17320161, ECO:0000269\|PubMed:17320163, ECO:0000269\|PubMed:18270511, ECO:0000269\|PubMed:19430464, ECO:0000269\|PubMed:27427228}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

1492_1587

1691.0

Compositional bias

Note=Lys-rich

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

19_60

1691.0

Domain

JmjN

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

437_603

1691.0

Domain

JmjC

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

84_174

1691.0

Domain

ARID

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

419_423

1691.0

Motif

GSGFP motif

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

1161_1218

1691.0

Zinc finger

PHD-type 2

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

1607_1661

1691.0

Zinc finger

PHD-type 3

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

293_343

1691.0

Zinc finger

PHD-type 1

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

676_728

1691.0

Zinc finger

C5HC2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1078_1103

2625.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1223_1284

2625.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

144_177

2625.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1078_1103

1360.6666666666667

Coiled coil

Ontology_term=ECO:0000255

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1223_1284

1360.6666666666667

Coiled coil

Ontology_term=ECO:0000255

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

144_177

1360.6666666666667

Coiled coil

Ontology_term=ECO:0000255

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

84_119

2625.0

Compositional bias

Note=Ser-rich

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

84_119

1360.6666666666667

Compositional bias

Note=Ser-rich

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

295_345

2625.0

Domain

Note=Myb-like

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

295_345

1360.6666666666667

Domain

Note=Myb-like

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

355_470

2625.0

Region

Note=Required for phosphorylation by CSNK2A1

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

823_1327

2625.0

Region

Note=9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N-G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R-E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X-D-L-E-E-T

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

355_470

1360.6666666666667

Region

Note=Required for phosphorylation by CSNK2A1

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

823_1327

1360.6666666666667

Region

Note=9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N-G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R-E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X-D-L-E-E-T

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1041_1094

2625.0

Repeat

Note=5

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1095_1148

2625.0

Repeat

Note=6

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1149_1203

2625.0

Repeat

Note=7

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1204_1257

2625.0

Repeat

Note=8%3B approximate

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1258_1327

2625.0

Repeat

Note=9%3B approximate

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

823_877

2625.0

Repeat

Note=1%3B approximate

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

878_932

2625.0

Repeat

Note=2

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

933_987

2625.0

Repeat

Note=3

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

988_1040

2625.0

Repeat

Note=4

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1041_1094

1360.6666666666667

Repeat

Note=5

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1095_1148

1360.6666666666667

Repeat

Note=6

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1149_1203

1360.6666666666667

Repeat

Note=7

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1204_1257

1360.6666666666667

Repeat

Note=8%3B approximate

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1258_1327

1360.6666666666667

Repeat

Note=9%3B approximate

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

823_877

1360.6666666666667

Repeat

Note=1%3B approximate

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

878_932

1360.6666666666667

Repeat

Note=2

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

933_987

1360.6666666666667

Repeat

Note=3

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

988_1040

1360.6666666666667

Repeat

Note=4

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>2082_BDP1_70811993_KDM5A_402303_ranked_0.pdb	BDP1	70811993	70811993	ENST00000399788	KDM5A	chr12	402303	-	MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSST VSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPD RSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRT KGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKR PFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDA EQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRT DPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKS VLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAE RKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTR FQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMET GLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRR KISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEV IDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEME TDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKR DIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSL DIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKR PKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCE	1555

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

BDP1_pLDDT.png

KDM5A_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
BDP1
KDM5A

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	BDP1	chr5:70811993	chr12:402303	ENST00000358731	+	1	39	1_299	0	2625.0	ZBTB43
Hgene	BDP1	chr5:70811993	chr12:402303	ENST00000380675	+	1	38	1_299	0	1360.6666666666667	ZBTB43

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Related Drugs to BDP1-KDM5A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to BDP1-KDM5A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source