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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:UBAP1-UNC13B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: UBAP1-UNC13B
	FusionPDB ID: 95915
	FusionGDB2.0 ID: 95915
		Hgene	Tgene
	Gene symbol	UBAP1	UNC13B
	Gene ID	51271	10497
	Gene name	ubiquitin associated protein 1	unc-13 homolog B
	Synonyms	NAG20\|SPG80\|UAP\|UBAP\|UBAP-1	MUNC13\|UNC13\|Unc13h2\|munc13-2
	Cytomap	9p13.3	9p13.3
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin-associated protein 1nasopharyngeal carcinoma-associated gene 20 protein	protein unc-13 homolog Bhomolog of rat Munc13 (diacylglycerol-binding)unc-13-like
	Modification date	20200313	20200329
	UniProtAcc	UMAD1	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000297661, ENST00000359544, ENST00000379186, ENST00000536252, ENST00000540348, ENST00000543944, ENST00000545103,	ENST00000481299, ENST00000378495, ENST00000378496, ENST00000396787,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	16 X 12 X 7=1344	12 X 10 X 7=840
	# samples	18	13
	** MAII score	log2(18/1344*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/840*10)=-2.69187770463767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: UBAP1 [Title/Abstract] AND UNC13B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	UBAP1(34220946)-UNC13B(35258990), # samples:3
Anticipated loss of major functional domain due to fusion event.	UBAP1-UNC13B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UBAP1-UNC13B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UBAP1-UNC13B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. UBAP1-UNC13B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. UBAP1-UNC13B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	UNC13B	GO:0043065	positive regulation of apoptotic process	10233166
Tgene	UNC13B	GO:0050714	positive regulation of protein secretion	19641095
Tgene	UNC13B	GO:0060478	acrosomal vesicle exocytosis	22248876
Tgene	UNC13B	GO:0071333	cellular response to glucose stimulus	19641095

Fusion gene breakpoints across UBAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UNC13B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-O2-A5IB-01A	UBAP1	chr9	34220946	-	UNC13B	chr9	35258990	+
ChimerDB4	LUSC	TCGA-O2-A5IB-01A	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
ChimerDB4	LUSC	TCGA-O2-A5IB	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000543944

UBAP1

chr9

34220946

ENST00000396787

UNC13B

chr9

35258990

4820

277

4677

1555

ENST00000543944

UBAP1

chr9

34220946

ENST00000378495

UNC13B

chr9

35258990

5890

277

4584

1524

ENST00000543944

UBAP1

chr9

34220946

ENST00000378496

UNC13B

chr9

35258990

4663

277

4641

1543

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000543944	ENST00000396787	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+	0.001334412	0.9986656
ENST00000543944	ENST00000378495	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+	0.002084703	0.9979153
ENST00000543944	ENST00000378496	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+	0.001385483	0.99861455

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>95915_95915_1_UBAP1-UNC13B_UBAP1_chr9_34220946_ENST00000543944_UNC13B_chr9_35258990_ENST00000378495_length(amino acids)=1524AA_BP=87
MSGAVRGRRREVGLQHGGCGTGGGYGDGLARSGQSWRWWRSLSLGAVGSSAGTEPGRPAGASTFRLLRRRQQRHSGSKWLLRSWVQIFMY
SSQEESQRKPLPTAAAQCSFEDPDSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSMQSYDLDY
PERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSHSLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKED
ATTHPPPDLVLQKDHFLGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLRRKKPLPL
VSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHE
KCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSAKITITVV
CAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVR
TLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDETAQEIVD
EFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRN
NFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGPSIRNLDF
WPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQ
VPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGK
VLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQM
ADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQLIFTAAK
ELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVD
DPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEEGPES

--------------------------------------------------------------

>95915_95915_2_UBAP1-UNC13B_UBAP1_chr9_34220946_ENST00000543944_UNC13B_chr9_35258990_ENST00000378496_length(amino acids)=1543AA_BP=87
MSGAVRGRRREVGLQHGGCGTGGGYGDGLARSGQSWRWWRSLSLGAVGSSAGTEPGRPAGASTFRLLRRRQQRHSGSKWLLRSWVQIFMY
SSQEESQRKPLPTAAAQCSFEDPDSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSMQSYDLDY
PERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSHSLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKED
ATTHPPPDLVLQKDHFLGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLRRKKPLPL
VSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHE
KCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSAKITITVV
CAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVR
TLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDETAQEIVD
EFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRN
NFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGPSIRNLDF
WPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQ
VPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGK
VLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQM
ADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQLIFTAAK
ELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQVHDGK
GIRFTANEDIRPEKGSGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWA
PKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFV

--------------------------------------------------------------

>95915_95915_3_UBAP1-UNC13B_UBAP1_chr9_34220946_ENST00000543944_UNC13B_chr9_35258990_ENST00000396787_length(amino acids)=1555AA_BP=87
MSGAVRGRRREVGLQHGGCGTGGGYGDGLARSGQSWRWWRSLSLGAVGSSAGTEPGRPAGASTFRLLRRRQQRHSGSKWLLRSWVQIFMY
SSQEESQRKPLPTAAAQCCHWTYLGWGEQQTFEDPDSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDS
CNDSMQSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSHSLSRDGQAGFGEQEKPLEVTGQAEK
EAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDS
MPDLRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQG
MRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGT
SKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRES
DDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWK
VYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLH
NSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPP
EEQGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHN
EYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILA
HYMRRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNS
FQVRIDECVRQMADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTD
QTGTQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTF
VRSQTTQVHDGKGIRFTANEDIRPEKGSGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKR
KFTTKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRILS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:34220946/chr9:35258990)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
UBAP1 UMAD1	.
137	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000543944

17_63

89.0

539.0

Domain

UMA

Tgene

UNC13B

chr9:34220946

chr9:35258990

ENST00000378495

1172_1202

156.0

1592.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

UNC13B

chr9:34220946

chr9:35258990

ENST00000378495

1013_1156

156.0

1592.0

Domain

MHD1

Tgene

UNC13B

chr9:34220946

chr9:35258990

ENST00000378495

1263_1405

156.0

1592.0

Domain

MHD2

Tgene

UNC13B

chr9:34220946

chr9:35258990

ENST00000378495

1419_1546

156.0

1592.0

Domain

C2 3

Tgene

UNC13B

chr9:34220946

chr9:35258990

ENST00000378495

583_707

156.0

1592.0

Domain

C2 2

Tgene

UNC13B

chr9:34220946

chr9:35258990

ENST00000378495

477_527

156.0

1592.0

Zinc finger

Phorbol-ester/DAG-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000297661

17_63

11.333333333333334

503.0

Domain

UMA

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000297661

389_430

11.333333333333334

503.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000297661

451_498

11.333333333333334

503.0

Domain

UBA 2

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000359544

17_63

11.333333333333334

503.0

Domain

UMA

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000359544

389_430

11.333333333333334

503.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000359544

451_498

11.333333333333334

503.0

Domain

UBA 2

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000379186

17_63

11.333333333333334

442.0

Domain

UMA

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000379186

389_430

11.333333333333334

442.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000379186

451_498

11.333333333333334

442.0

Domain

UBA 2

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000536252

17_63

11.333333333333334

503.0

Domain

UMA

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000536252

389_430

11.333333333333334

503.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000536252

451_498

11.333333333333334

503.0

Domain

UBA 2

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000540348

17_63

11.333333333333334

503.0

Domain

UMA

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000540348

389_430

11.333333333333334

503.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000540348

451_498

11.333333333333334

503.0

Domain

UBA 2

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000543944

389_430

89.0

539.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000543944

451_498

89.0

539.0

Domain

UBA 2

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000545103

17_63

567.0

Domain

UMA

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000545103

389_430

567.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000545103

451_498

567.0

Domain

UBA 2

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>2084_UBAP1_34220946_UNC13B_35258990_ranked_0.pdb	UBAP1	34220946	34220946	ENST00000378496	UNC13B	chr9	35258990	+	MSGAVRGRRREVGLQHGGCGTGGGYGDGLARSGQSWRWWRSLSLGAVGSSAGTEPGRPAGASTFRLLRRRQQRHSGSKWLLRSWVQIFMY SSQEESQRKPLPTAAAQCCHWTYLGWGEQQTFEDPDSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDS CNDSMQSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSHSLSRDGQAGFGEQEKPLEVTGQAEK EAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDS MPDLRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQG MRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGT SKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRES DDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWK VYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLH NSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPP EEQGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHN EYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILA HYMRRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNS FQVRIDECVRQMADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTD QTGTQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTF VRSQTTQVHDGKGIRFTANEDIRPEKGSGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKR KFTTKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRILS	1555

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

UBAP1_pLDDT.png

UNC13B_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
UBAP1
UNC13B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000297661	+	2	7	1_95	11.333333333333334	503.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000359544	+	2	7	1_95	11.333333333333334	503.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000379186	+	2	6	1_95	11.333333333333334	442.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000536252	+	3	8	1_95	11.333333333333334	503.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000540348	+	3	8	1_95	11.333333333333334	503.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000543944	+	2	6	1_95	89.0	539.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000545103	+	1	6	1_95	0	567.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000297661	+	2	7	260_290	11.333333333333334	503.0	PTPN23
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000359544	+	2	7	260_290	11.333333333333334	503.0	PTPN23
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000379186	+	2	6	260_290	11.333333333333334	442.0	PTPN23
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000536252	+	3	8	260_290	11.333333333333334	503.0	PTPN23
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000540348	+	3	8	260_290	11.333333333333334	503.0	PTPN23
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000543944	+	2	6	260_290	89.0	539.0	PTPN23
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000545103	+	1	6	260_290	0	567.0	PTPN23

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Related Drugs to UBAP1-UNC13B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to UBAP1-UNC13B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source