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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:UBQLN1-NLRP5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: UBQLN1-NLRP5
FusionPDB ID: 96404
FusionGDB2.0 ID: 96404
HgeneTgene
Gene symbol

UBQLN1

NLRP5

Gene ID

29979

126206

Gene nameubiquilin 1NLR family pyrin domain containing 5
SynonymsDA41|DSK2|PLIC-1|UBQN|XDRP1CLR19.8|MATER|NALP5|PAN11|PYPAF8
Cytomap

9q21.32|9q21.2-q21.3

19q13.43

Type of geneprotein-codingprotein-coding
Descriptionubiquilin-1hPLIC-1protein linking IAP with cytoskeleton 1testicular tissue protein Li 219NACHT, LRR and PYD domains-containing protein 5NACHT, leucine rich repeat and PYD containing 5mater protein homologmaternal antigen that embryos requirenucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000257468, ENST00000376395, 
ENST00000390649, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 12 X 8=13444 X 6 X 3=72
# samples 165
** MAII scorelog2(16/1344*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: UBQLN1 [Title/Abstract] AND NLRP5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)UBQLN1(86292642)-NLRP5(56531741), # samples:1
UBQLN1(86292641)-NLRP5(56530707), # samples:1
UBQLN1(86292641)-NLRP5(56531740), # samples:1
Anticipated loss of major functional domain due to fusion event.UBQLN1-NLRP5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UBQLN1-NLRP5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UBQLN1-NLRP5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UBQLN1-NLRP5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBQLN1

GO:0031396

regulation of protein ubiquitination

12634373

HgeneUBQLN1

GO:0031398

positive regulation of protein ubiquitination

23307288

HgeneUBQLN1

GO:0035973

aggrephagy

21143716


check buttonFusion gene breakpoints across UBQLN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NLRP5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6YR-01AUBQLN1chr9

86292642

-NLRP5chr19

56531741

+
ChimerDB4SARCTCGA-DX-A6YRUBQLN1chr9

86292641

-NLRP5chr19

56530707

+
ChimerDB4SARCTCGA-DX-A6YRUBQLN1chr9

86292641

-NLRP5chr19

56531740

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376395UBQLN1chr986292642-ENST00000390649NLRP5chr1956531741+4895162952446091361
ENST00000257468UBQLN1chr986292642-ENST00000390649NLRP5chr1956531741+4626136025543401361
ENST00000376395UBQLN1chr986292641-ENST00000390649NLRP5chr1956530707+4952162952446661380
ENST00000257468UBQLN1chr986292641-ENST00000390649NLRP5chr1956530707+4683136025543971380
ENST00000376395UBQLN1chr986292641-ENST00000390649NLRP5chr1956531740+4895162952446091361
ENST00000257468UBQLN1chr986292641-ENST00000390649NLRP5chr1956531740+4626136025543401361

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376395ENST00000390649UBQLN1chr986292642-NLRP5chr1956531741+0.0014615130.9985385
ENST00000257468ENST00000390649UBQLN1chr986292642-NLRP5chr1956531741+0.0011033940.9988966
ENST00000376395ENST00000390649UBQLN1chr986292641-NLRP5chr1956530707+0.0015746860.99842536
ENST00000257468ENST00000390649UBQLN1chr986292641-NLRP5chr1956530707+0.0011840220.998816
ENST00000376395ENST00000390649UBQLN1chr986292641-NLRP5chr1956531740+0.0014615130.9985385
ENST00000257468ENST00000390649UBQLN1chr986292641-NLRP5chr1956531740+0.0011033940.9988966

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>96404_96404_1_UBQLN1-NLRP5_UBQLN1_chr9_86292641_ENST00000257468_NLRP5_chr19_56530707_ENST00000390649_length(amino acids)=1380AA_BP=387
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDT
LSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLL
SNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYN
ALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTA
PNLVPGVGEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAF
DSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFI
IDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQ
KTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVW
NRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHS
LWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDL
IASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC
KIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLS
LAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQC
HLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDG
GVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKL

--------------------------------------------------------------

>96404_96404_2_UBQLN1-NLRP5_UBQLN1_chr9_86292641_ENST00000257468_NLRP5_chr19_56531740_ENST00000390649_length(amino acids)=1361AA_BP=368
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDT
LSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLL
SNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYN
ALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTA
PNLVPGVGEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSG
IGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCK
DWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQ
VPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGES
ELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPL
EVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVD
VKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHL
WRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALR
VSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSW
LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARL
GLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHS

--------------------------------------------------------------

>96404_96404_3_UBQLN1-NLRP5_UBQLN1_chr9_86292641_ENST00000376395_NLRP5_chr19_56530707_ENST00000390649_length(amino acids)=1380AA_BP=387
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDT
LSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLL
SNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYN
ALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTA
PNLVPGVGEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAF
DSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFI
IDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQ
KTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVW
NRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHS
LWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDL
IASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC
KIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLS
LAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQC
HLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDG
GVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKL

--------------------------------------------------------------

>96404_96404_4_UBQLN1-NLRP5_UBQLN1_chr9_86292641_ENST00000376395_NLRP5_chr19_56531740_ENST00000390649_length(amino acids)=1361AA_BP=368
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDT
LSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLL
SNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYN
ALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTA
PNLVPGVGEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSG
IGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCK
DWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQ
VPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGES
ELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPL
EVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVD
VKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHL
WRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALR
VSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSW
LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARL
GLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHS

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>96404_96404_5_UBQLN1-NLRP5_UBQLN1_chr9_86292642_ENST00000257468_NLRP5_chr19_56531741_ENST00000390649_length(amino acids)=1361AA_BP=368
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDT
LSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLL
SNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYN
ALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTA
PNLVPGVGEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSG
IGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCK
DWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQ
VPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGES
ELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPL
EVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVD
VKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHL
WRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALR
VSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSW
LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARL
GLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHS

--------------------------------------------------------------

>96404_96404_6_UBQLN1-NLRP5_UBQLN1_chr9_86292642_ENST00000376395_NLRP5_chr19_56531741_ENST00000390649_length(amino acids)=1361AA_BP=368
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDT
LSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLL
SNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYN
ALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTA
PNLVPGVGEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSG
IGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCK
DWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQ
VPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGES
ELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPL
EVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVD
VKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHL
WRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALR
VSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSW
LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARL
GLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:86292642/chr19:56531741)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-610182_210368.3333333333333562.0DomainSTI1 1
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-610212_251368.3333333333333562.0DomainSTI1 2
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-61037_111368.3333333333333562.0DomainUbiquitin-like
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-611182_210368.3333333333333590.0DomainSTI1 1
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-611212_251368.3333333333333590.0DomainSTI1 2
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-61137_111368.3333333333333590.0DomainUbiquitin-like
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-610182_210368.3333333333333562.0DomainSTI1 1
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-610212_251368.3333333333333562.0DomainSTI1 2
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-61037_111368.3333333333333562.0DomainUbiquitin-like
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-611182_210368.3333333333333590.0DomainSTI1 1
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-611212_251368.3333333333333590.0DomainSTI1 2
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-61137_111368.3333333333333590.0DomainUbiquitin-like
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-610182_210368.3333333333333562.0DomainSTI1 1
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-610212_251368.3333333333333562.0DomainSTI1 2
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-61037_111368.3333333333333562.0DomainUbiquitin-like
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-611182_210368.3333333333333590.0DomainSTI1 1
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-611212_251368.3333333333333590.0DomainSTI1 2
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-61137_111368.3333333333333590.0DomainUbiquitin-like
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315280_602188.333333333333341201.0DomainNACHT
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415280_602207.333333333333341201.0DomainNACHT
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415280_602207.333333333333341201.0DomainNACHT
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315286_293188.333333333333341201.0Nucleotide bindingATP
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415286_293207.333333333333341201.0Nucleotide bindingATP
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415286_293207.333333333333341201.0Nucleotide bindingATP
TgeneNLRP5chr9:86292641chr19:56530707ENST000003906493151007_1034188.333333333333341201.0RepeatNote=LRR 10
TgeneNLRP5chr9:86292641chr19:56530707ENST000003906493151036_1059188.333333333333341201.0RepeatNote=LRR 11
TgeneNLRP5chr9:86292641chr19:56530707ENST000003906493151064_1092188.333333333333341201.0RepeatNote=LRR 12
TgeneNLRP5chr9:86292641chr19:56530707ENST000003906493151121_1142188.333333333333341201.0RepeatNote=LRR 13
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315704_727188.333333333333341201.0RepeatNote=LRR 1
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315730_753188.333333333333341201.0RepeatNote=LRR 2
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315780_803188.333333333333341201.0RepeatNote=LRR 3
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315809_832188.333333333333341201.0RepeatNote=LRR 4
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315836_863188.333333333333341201.0RepeatNote=LRR 5
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315865_892188.333333333333341201.0RepeatNote=LRR 6
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315893_916188.333333333333341201.0RepeatNote=LRR 7
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315950_973188.333333333333341201.0RepeatNote=LRR 8
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315979_1002188.333333333333341201.0RepeatNote=LRR 9
TgeneNLRP5chr9:86292641chr19:56531740ENST000003906494151007_1034207.333333333333341201.0RepeatNote=LRR 10
TgeneNLRP5chr9:86292641chr19:56531740ENST000003906494151036_1059207.333333333333341201.0RepeatNote=LRR 11
TgeneNLRP5chr9:86292641chr19:56531740ENST000003906494151064_1092207.333333333333341201.0RepeatNote=LRR 12
TgeneNLRP5chr9:86292641chr19:56531740ENST000003906494151121_1142207.333333333333341201.0RepeatNote=LRR 13
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415704_727207.333333333333341201.0RepeatNote=LRR 1
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415730_753207.333333333333341201.0RepeatNote=LRR 2
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415780_803207.333333333333341201.0RepeatNote=LRR 3
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415809_832207.333333333333341201.0RepeatNote=LRR 4
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415836_863207.333333333333341201.0RepeatNote=LRR 5
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415865_892207.333333333333341201.0RepeatNote=LRR 6
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415893_916207.333333333333341201.0RepeatNote=LRR 7
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415950_973207.333333333333341201.0RepeatNote=LRR 8
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415979_1002207.333333333333341201.0RepeatNote=LRR 9
TgeneNLRP5chr9:86292642chr19:56531741ENST000003906494151007_1034207.333333333333341201.0RepeatNote=LRR 10
TgeneNLRP5chr9:86292642chr19:56531741ENST000003906494151036_1059207.333333333333341201.0RepeatNote=LRR 11
TgeneNLRP5chr9:86292642chr19:56531741ENST000003906494151064_1092207.333333333333341201.0RepeatNote=LRR 12
TgeneNLRP5chr9:86292642chr19:56531741ENST000003906494151121_1142207.333333333333341201.0RepeatNote=LRR 13
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415704_727207.333333333333341201.0RepeatNote=LRR 1
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415730_753207.333333333333341201.0RepeatNote=LRR 2
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415780_803207.333333333333341201.0RepeatNote=LRR 3
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415809_832207.333333333333341201.0RepeatNote=LRR 4
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415836_863207.333333333333341201.0RepeatNote=LRR 5
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415865_892207.333333333333341201.0RepeatNote=LRR 6
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415893_916207.333333333333341201.0RepeatNote=LRR 7
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415950_973207.333333333333341201.0RepeatNote=LRR 8
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415979_1002207.333333333333341201.0RepeatNote=LRR 9

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-610387_434368.3333333333333562.0DomainSTI1 3
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-610438_470368.3333333333333562.0DomainSTI1 4
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-610546_586368.3333333333333562.0DomainUBA
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-611387_434368.3333333333333590.0DomainSTI1 3
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-611438_470368.3333333333333590.0DomainSTI1 4
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-611546_586368.3333333333333590.0DomainUBA
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-610387_434368.3333333333333562.0DomainSTI1 3
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-610438_470368.3333333333333562.0DomainSTI1 4
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-610546_586368.3333333333333562.0DomainUBA
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-611387_434368.3333333333333590.0DomainSTI1 3
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-611438_470368.3333333333333590.0DomainSTI1 4
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-611546_586368.3333333333333590.0DomainUBA
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-610387_434368.3333333333333562.0DomainSTI1 3
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-610438_470368.3333333333333562.0DomainSTI1 4
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-610546_586368.3333333333333562.0DomainUBA
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-611387_434368.3333333333333590.0DomainSTI1 3
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-611438_470368.3333333333333590.0DomainSTI1 4
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-611546_586368.3333333333333590.0DomainUBA
TgeneNLRP5chr9:86292641chr19:56530707ENST0000039064931557_148188.333333333333341201.0DomainPyrin
TgeneNLRP5chr9:86292641chr19:56531740ENST0000039064941557_148207.333333333333341201.0DomainPyrin
TgeneNLRP5chr9:86292642chr19:56531741ENST0000039064941557_148207.333333333333341201.0DomainPyrin


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
UBQLN1
NLRP5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-610178_428368.3333333333333562.0UBXN4
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-611178_428368.3333333333333590.0UBXN4
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-610178_428368.3333333333333562.0UBXN4
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-611178_428368.3333333333333590.0UBXN4
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-610178_428368.3333333333333562.0UBXN4
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-611178_428368.3333333333333590.0UBXN4


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Related Drugs to UBQLN1-NLRP5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to UBQLN1-NLRP5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource