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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:UBR4-ASAH1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: UBR4-ASAH1
	FusionPDB ID: 96444
	FusionGDB2.0 ID: 96444
		Hgene	Tgene
	Gene symbol	UBR4	ASAH1
	Gene ID	23352	427
	Gene name	ubiquitin protein ligase E3 component n-recognin 4	N-acylsphingosine amidohydrolase 1
	Synonyms	RBAF600\|ZUBR1\|p600	AC\|ACDase\|ASAH\|PHP\|PHP32\|SMAPME
	Cytomap	1p36.13	8p22
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase UBR4N-recognin-4RING-type E3 ubiquitin transferase UBR4retinoblastoma-associated factor 600-like proteinretinoblastoma-associated factor of 600 kDazinc finger UBR1-type protein 1	acid ceramidaseN-acylethanolamine hydrolase ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 1acid CDaseacylsphingosine deacylaseputative 32 kDa heart protein
	Modification date	20200313	20200313
	UniProtAcc	.	Q13510
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000375217, ENST00000375226, ENST00000375254, ENST00000375267, ENST00000375218, ENST00000375224, ENST00000375225, ENST00000429347, ENST00000467272, ENST00000543981,	ENST00000520051, ENST00000262097, ENST00000314146, ENST00000381733, ENST00000417108, ENST00000520781,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 14 X 7=1372	13 X 10 X 8=1040
	# samples	14	16
	** MAII score	log2(14/1372*10)=-3.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1040*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: UBR4 [Title/Abstract] AND ASAH1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	UBR4(19518681)-ASAH1(17919932), # samples:1
Anticipated loss of major functional domain due to fusion event.	UBR4-ASAH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UBR4-ASAH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UBR4-ASAH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. UBR4-ASAH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UBR4	GO:0006511	ubiquitin-dependent protein catabolic process	23932781
Tgene	ASAH1	GO:0046512	sphingosine biosynthetic process	12815059
Tgene	ASAH1	GO:0046513	ceramide biosynthetic process	12764132\|12815059
Tgene	ASAH1	GO:0046514	ceramide catabolic process	12815059

Fusion gene breakpoints across UBR4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ASAH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AC-A2FG	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000375217	UBR4	chr1	19518681	-	ENST00000262097	ASAH1	chr8	17919932	-	3192	1398	4	2082	692
ENST00000375217	UBR4	chr1	19518681	-	ENST00000381733	ASAH1	chr8	17919932	-	3191	1398	4	2082	692
ENST00000375217	UBR4	chr1	19518681	-	ENST00000417108	ASAH1	chr8	17919932	-	3165	1398	4	2082	692
ENST00000375217	UBR4	chr1	19518681	-	ENST00000520781	ASAH1	chr8	17919932	-	3165	1398	4	2082	692
ENST00000375217	UBR4	chr1	19518681	-	ENST00000314146	ASAH1	chr8	17919932	-	2419	1398	4	2082	692
ENST00000375226	UBR4	chr1	19518681	-	ENST00000262097	ASAH1	chr8	17919932	-	3192	1398	4	2082	692
ENST00000375226	UBR4	chr1	19518681	-	ENST00000381733	ASAH1	chr8	17919932	-	3191	1398	4	2082	692
ENST00000375226	UBR4	chr1	19518681	-	ENST00000417108	ASAH1	chr8	17919932	-	3165	1398	4	2082	692
ENST00000375226	UBR4	chr1	19518681	-	ENST00000520781	ASAH1	chr8	17919932	-	3165	1398	4	2082	692
ENST00000375226	UBR4	chr1	19518681	-	ENST00000314146	ASAH1	chr8	17919932	-	2419	1398	4	2082	692
ENST00000375267	UBR4	chr1	19518681	-	ENST00000262097	ASAH1	chr8	17919932	-	3192	1398	4	2082	692
ENST00000375267	UBR4	chr1	19518681	-	ENST00000381733	ASAH1	chr8	17919932	-	3191	1398	4	2082	692
ENST00000375267	UBR4	chr1	19518681	-	ENST00000417108	ASAH1	chr8	17919932	-	3165	1398	4	2082	692
ENST00000375267	UBR4	chr1	19518681	-	ENST00000520781	ASAH1	chr8	17919932	-	3165	1398	4	2082	692
ENST00000375267	UBR4	chr1	19518681	-	ENST00000314146	ASAH1	chr8	17919932	-	2419	1398	4	2082	692
ENST00000375254	UBR4	chr1	19518681	-	ENST00000262097	ASAH1	chr8	17919932	-	3216	1422	28	2106	692
ENST00000375254	UBR4	chr1	19518681	-	ENST00000381733	ASAH1	chr8	17919932	-	3215	1422	28	2106	692
ENST00000375254	UBR4	chr1	19518681	-	ENST00000417108	ASAH1	chr8	17919932	-	3189	1422	28	2106	692
ENST00000375254	UBR4	chr1	19518681	-	ENST00000520781	ASAH1	chr8	17919932	-	3189	1422	28	2106	692
ENST00000375254	UBR4	chr1	19518681	-	ENST00000314146	ASAH1	chr8	17919932	-	2443	1422	28	2106	692

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000375217	ENST00000262097	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000948045	0.999052
ENST00000375217	ENST00000381733	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000951685	0.9990483
ENST00000375217	ENST00000417108	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000880895	0.9991191
ENST00000375217	ENST00000520781	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000880895	0.9991191
ENST00000375217	ENST00000314146	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.004018062	0.99598193
ENST00000375226	ENST00000262097	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000948045	0.999052
ENST00000375226	ENST00000381733	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000951685	0.9990483
ENST00000375226	ENST00000417108	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000880895	0.9991191
ENST00000375226	ENST00000520781	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000880895	0.9991191
ENST00000375226	ENST00000314146	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.004018062	0.99598193
ENST00000375267	ENST00000262097	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000948045	0.999052
ENST00000375267	ENST00000381733	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000951685	0.9990483
ENST00000375267	ENST00000417108	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000880895	0.9991191
ENST00000375267	ENST00000520781	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000880895	0.9991191
ENST00000375267	ENST00000314146	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.004018062	0.99598193
ENST00000375254	ENST00000262097	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000967059	0.999033
ENST00000375254	ENST00000381733	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.000970751	0.9990293
ENST00000375254	ENST00000417108	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.00089581	0.9991042
ENST00000375254	ENST00000520781	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.00089581	0.9991042
ENST00000375254	ENST00000314146	UBR4	chr1	19518681	-	ASAH1	chr8	17919932	-	0.00417639	0.9958236

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>96444_96444_1_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375217_ASAH1_chr8_17919932_ENST00000262097_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_2_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375217_ASAH1_chr8_17919932_ENST00000314146_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_3_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375217_ASAH1_chr8_17919932_ENST00000381733_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_4_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375217_ASAH1_chr8_17919932_ENST00000417108_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_5_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375217_ASAH1_chr8_17919932_ENST00000520781_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_6_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375226_ASAH1_chr8_17919932_ENST00000262097_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_7_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375226_ASAH1_chr8_17919932_ENST00000314146_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_8_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375226_ASAH1_chr8_17919932_ENST00000381733_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_9_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375226_ASAH1_chr8_17919932_ENST00000417108_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_10_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375226_ASAH1_chr8_17919932_ENST00000520781_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_11_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375254_ASAH1_chr8_17919932_ENST00000262097_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_12_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375254_ASAH1_chr8_17919932_ENST00000314146_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_13_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375254_ASAH1_chr8_17919932_ENST00000381733_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_14_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375254_ASAH1_chr8_17919932_ENST00000417108_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_15_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375254_ASAH1_chr8_17919932_ENST00000520781_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_16_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375267_ASAH1_chr8_17919932_ENST00000262097_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_17_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375267_ASAH1_chr8_17919932_ENST00000314146_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_18_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375267_ASAH1_chr8_17919932_ENST00000381733_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_19_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375267_ASAH1_chr8_17919932_ENST00000417108_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

>96444_96444_20_UBR4-ASAH1_UBR4_chr1_19518681_ENST00000375267_ASAH1_chr8_17919932_ENST00000520781_length(amino acids)=692AA_BP=465
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCS
LIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYI
NRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGK
KDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:19518681/chr8:17919932)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ASAH1 Q13510
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (PubMed:10610716, PubMed:7744740, PubMed:15655246, PubMed:11451951). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:10610716). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (PubMed:7744740, PubMed:15655246). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:12764132, PubMed:12815059). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (PubMed:12764132). Has also an N-acylethanolamine hydrolase activity (PubMed:15655246). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (PubMed:17713573). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (PubMed:22261821). {ECO:0000250\|UniProtKB:Q9WV54, ECO:0000269\|PubMed:10610716, ECO:0000269\|PubMed:11451951, ECO:0000269\|PubMed:12764132, ECO:0000269\|PubMed:12815059, ECO:0000269\|PubMed:15655246, ECO:0000269\|PubMed:17713573, ECO:0000269\|PubMed:22261821, ECO:0000269\|PubMed:7744740, ECO:0000303\|PubMed:10610716}.; FUNCTION: [Isoform 2]: May directly regulate steroidogenesis by binding the nuclear receptor NR5A1 and negatively regulating its transcriptional activity. {ECO:0000305\|PubMed:22927646}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375217

106

9_15

464.6666666666667

5177.0

Compositional bias

Note=Poly-Ala

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375226

106

9_15

464.6666666666667

5160.0

Compositional bias

Note=Poly-Ala

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375254

106

9_15

464.6666666666667

5184.0

Compositional bias

Note=Poly-Ala

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375267

107

9_15

464.6666666666667

5205.0

Compositional bias

Note=Poly-Ala

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375217

106

2728_2738

464.6666666666667

5177.0

Compositional bias

Note=Poly-Asp

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375217

106

3339_3370

464.6666666666667

5177.0

Compositional bias

Note=Ser-rich

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375217

106

608_631

464.6666666666667

5177.0

Compositional bias

Note=Pro-rich

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375218

2728_2738

213.0

Compositional bias

Note=Poly-Asp

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375218

3339_3370

213.0

Compositional bias

Note=Ser-rich

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375218

608_631

213.0

Compositional bias

Note=Pro-rich

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375218

9_15

213.0

Compositional bias

Note=Poly-Ala

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375226

106

2728_2738

464.6666666666667

5160.0

Compositional bias

Note=Poly-Asp

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375226

106

3339_3370

464.6666666666667

5160.0

Compositional bias

Note=Ser-rich

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375226

106

608_631

464.6666666666667

5160.0

Compositional bias

Note=Pro-rich

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375254

106

2728_2738

464.6666666666667

5184.0

Compositional bias

Note=Poly-Asp

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375254

106

3339_3370

464.6666666666667

5184.0

Compositional bias

Note=Ser-rich

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375254

106

608_631

464.6666666666667

5184.0

Compositional bias

Note=Pro-rich

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375267

107

2728_2738

464.6666666666667

5205.0

Compositional bias

Note=Poly-Asp

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375267

107

3339_3370

464.6666666666667

5205.0

Compositional bias

Note=Ser-rich

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375267

107

608_631

464.6666666666667

5205.0

Compositional bias

Note=Pro-rich

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375217

106

850_870

464.6666666666667

5177.0

Transmembrane

Helical

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375217

106

993_1013

464.6666666666667

5177.0

Transmembrane

Helical

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375218

850_870

213.0

Transmembrane

Helical

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375218

993_1013

213.0

Transmembrane

Helical

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375226

106

850_870

464.6666666666667

5160.0

Transmembrane

Helical

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375226

106

993_1013

464.6666666666667

5160.0

Transmembrane

Helical

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375254

106

850_870

464.6666666666667

5184.0

Transmembrane

Helical

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375254

106

993_1013

464.6666666666667

5184.0

Transmembrane

Helical

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375267

107

850_870

464.6666666666667

5205.0

Transmembrane

Helical

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375267

107

993_1013

464.6666666666667

5205.0

Transmembrane

Helical

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375217

106

1656_1729

464.6666666666667

5177.0

Zinc finger

UBR-type

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375218

1656_1729

213.0

Zinc finger

UBR-type

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375226

106

1656_1729

464.6666666666667

5160.0

Zinc finger

UBR-type

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375254

106

1656_1729

464.6666666666667

5184.0

Zinc finger

UBR-type

Hgene

UBR4

chr1:19518681

chr8:17919932

ENST00000375267

107

1656_1729

464.6666666666667

5205.0

Zinc finger

UBR-type

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
UBR4
ASAH1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to UBR4-ASAH1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to UBR4-ASAH1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source