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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:UBTF-MAML3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: UBTF-MAML3
FusionPDB ID: 96498
FusionGDB2.0 ID: 96498
HgeneTgene
Gene symbol

UBTF

MAML3

Gene ID

7343

55534

Gene nameupstream binding transcription factormastermind like transcriptional coactivator 3
SynonymsCONDBA|NOR-90|UBF|UBF-1|UBF1|UBF2CAGH3|ERDA3|GDN|MAM-2|MAM2|TNRC3|mam-3
Cytomap

17q21.31

4q31.1

Type of geneprotein-codingprotein-coding
Descriptionnucleolar transcription factor 190-kDa nucleolus organizer region autoantigenautoantigen NOR-90upstream binding transcription factor, RNA polymerase Imastermind-like protein 3CAG repeat containing (glia-derived nexin I alpha)expanded repeat domain, CAG/CTG 3polyglutamine richtrinucleotide repeat containing 3
Modification date2020031320200313
UniProtAcc.

Q96JK9

Ensembl transtripts involved in fusion geneENST idsENST00000302904, ENST00000343638, 
ENST00000393606, ENST00000436088, 
ENST00000526094, ENST00000527034, 
ENST00000529383, ENST00000533177, 
ENST00000537550, 		ENST00000398940, 
ENST00000327122, ENST00000509479, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 12 X 8=105613 X 13 X 8=1352
# samples 1316
** MAII scorelog2(13/1056*10)=-3.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1352*10)=-3.07895134139482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: UBTF [Title/Abstract] AND MAML3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)UBTF(42286720)-MAML3(140812121), # samples:11
Anticipated loss of major functional domain due to fusion event.UBTF-MAML3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UBTF-MAML3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UBTF-MAML3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UBTF-MAML3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UBTF-MAML3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBTF

GO:1902659

regulation of glucose mediated signaling pathway

22368283

TgeneMAML3

GO:0007219

Notch signaling pathway

12370315

TgeneMAML3

GO:0045944

positive regulation of transcription by RNA polymerase II

12370315


check buttonFusion gene breakpoints across UBTF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAML3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-P8-A5KC-01AUBTFchr17

42287492

-MAML3chr4

140812121

-
ChimerDB4PCPGTCGA-PR-A5PF-01AUBTFchr17

42286720

-MAML3chr4

140812121

-
ChimerDB4PCPGTCGA-PR-A5PH-01AUBTFchr17

42286720

-MAML3chr4

140812121

-
ChimerDB4PCPGTCGA-QR-A70H-01AUBTFchr17

42286720

-MAML3chr4

140812121

-
ChimerDB4PCPGTCGA-RW-A686-01AUBTFchr17

42287492

-MAML3chr4

140812121

-
ChimerDB4PCPGTCGA-RW-A686-06AUBTFchr17

42287492

-MAML3chr4

140812121

-
ChimerDB4PCPGTCGA-RW-A8AZ-01AUBTFchr17

42287492

-MAML3chr4

140812121

-
ChimerDB4PCPGTCGA-WB-A80K-01AUBTFchr17

42286720

-MAML3chr4

140812121

-
ChimerDB4PCPGTCGA-WB-A80KUBTFchr17

42286719

-MAML3chr4

140812121

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000302904UBTFchr1742287492-ENST00000509479MAML3chr4140812121-7638211947850671529
ENST00000302904UBTFchr1742287492-ENST00000327122MAML3chr4140812121-3748211947837471090
ENST00000529383UBTFchr1742287492-ENST00000509479MAML3chr4140812121-7418189925848471529
ENST00000529383UBTFchr1742287492-ENST00000327122MAML3chr4140812121-3528189925835271090
ENST00000526094UBTFchr1742287492-ENST00000509479MAML3chr4140812121-7307178825847361492
ENST00000526094UBTFchr1742287492-ENST00000327122MAML3chr4140812121-3417178825834161053
ENST00000302904UBTFchr1742286720-ENST00000509479MAML3chr4140812121-7917239847853461622
ENST00000302904UBTFchr1742286720-ENST00000327122MAML3chr4140812121-4027239847840261183
ENST00000529383UBTFchr1742286720-ENST00000509479MAML3chr4140812121-7697217825851261622
ENST00000529383UBTFchr1742286720-ENST00000327122MAML3chr4140812121-3807217825838061183
ENST00000526094UBTFchr1742286720-ENST00000509479MAML3chr4140812121-7586206725850151585
ENST00000526094UBTFchr1742286720-ENST00000327122MAML3chr4140812121-3696206725836951146
ENST00000302904UBTFchr1742286719-ENST00000509479MAML3chr4140812121-7917239847853461622
ENST00000302904UBTFchr1742286719-ENST00000327122MAML3chr4140812121-4027239847840261183
ENST00000529383UBTFchr1742286719-ENST00000509479MAML3chr4140812121-7697217825851261622
ENST00000529383UBTFchr1742286719-ENST00000327122MAML3chr4140812121-3807217825838061183
ENST00000526094UBTFchr1742286719-ENST00000509479MAML3chr4140812121-7586206725850151585
ENST00000526094UBTFchr1742286719-ENST00000327122MAML3chr4140812121-3696206725836951146

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000302904ENST00000509479UBTFchr1742287492-MAML3chr4140812121-0.0091483620.9908516
ENST00000302904ENST00000327122UBTFchr1742287492-MAML3chr4140812121-0.065509440.93449056
ENST00000529383ENST00000509479UBTFchr1742287492-MAML3chr4140812121-0.0054956470.99450433
ENST00000529383ENST00000327122UBTFchr1742287492-MAML3chr4140812121-0.14200580.85799426
ENST00000526094ENST00000509479UBTFchr1742287492-MAML3chr4140812121-0.0053271650.99467283
ENST00000526094ENST00000327122UBTFchr1742287492-MAML3chr4140812121-0.202822550.79717743
ENST00000302904ENST00000509479UBTFchr1742286720-MAML3chr4140812121-0.0088742370.99112576
ENST00000302904ENST00000327122UBTFchr1742286720-MAML3chr4140812121-0.106261520.8937385
ENST00000529383ENST00000509479UBTFchr1742286720-MAML3chr4140812121-0.005352560.99464744
ENST00000529383ENST00000327122UBTFchr1742286720-MAML3chr4140812121-0.281188820.7188112
ENST00000526094ENST00000509479UBTFchr1742286720-MAML3chr4140812121-0.0051754890.9948245
ENST00000526094ENST00000327122UBTFchr1742286720-MAML3chr4140812121-0.319098030.68090194
ENST00000302904ENST00000509479UBTFchr1742286719-MAML3chr4140812121-0.0088742370.99112576
ENST00000302904ENST00000327122UBTFchr1742286719-MAML3chr4140812121-0.106261520.8937385
ENST00000529383ENST00000509479UBTFchr1742286719-MAML3chr4140812121-0.005352560.99464744
ENST00000529383ENST00000327122UBTFchr1742286719-MAML3chr4140812121-0.281188820.7188112
ENST00000526094ENST00000509479UBTFchr1742286719-MAML3chr4140812121-0.0051754890.9948245
ENST00000526094ENST00000327122UBTFchr1742286719-MAML3chr4140812121-0.319098030.68090194

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>96498_96498_1_UBTF-MAML3_UBTF_chr17_42286719_ENST00000302904_MAML3_chr4_140812121_ENST00000327122_length(amino acids)=1183AA_BP=640
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQ
KHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYE
VELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMW
NDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAA
EDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQKQ
YKVHLDLWVKLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHT
PGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQ
DLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQ
SPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQ
QQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNI
LTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYA

--------------------------------------------------------------

>96498_96498_2_UBTF-MAML3_UBTF_chr17_42286719_ENST00000302904_MAML3_chr4_140812121_ENST00000509479_length(amino acids)=1622AA_BP=640
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQ
KHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYE
VELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMW
NDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAA
EDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQKQ
YKVHLDLWVKLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHT
PGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQ
DLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQ
SPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQ
QQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNI
LTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYA
ALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAE
QQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPT
SQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTV
QQGAQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPM
VMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFG

--------------------------------------------------------------

>96498_96498_3_UBTF-MAML3_UBTF_chr17_42286719_ENST00000526094_MAML3_chr4_140812121_ENST00000327122_length(amino acids)=1146AA_BP=603
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPP
NSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPAS
KKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLP
ESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPM
NGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQKQYKVHLDLWVKLQETVKRKLEGARSPLNGDQQNGACDG
NFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKD
LKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSH
SPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASG
PVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMY
PQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQ

--------------------------------------------------------------

>96498_96498_4_UBTF-MAML3_UBTF_chr17_42286719_ENST00000526094_MAML3_chr4_140812121_ENST00000509479_length(amino acids)=1585AA_BP=603
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPP
NSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPAS
KKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLP
ESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPM
NGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQKQYKVHLDLWVKLQETVKRKLEGARSPLNGDQQNGACDG
NFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKD
LKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSH
SPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASG
PVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMY
PQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQ
QQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGAS
PAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAEQQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAA
VRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQP
ASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAG
QPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQA

--------------------------------------------------------------

>96498_96498_5_UBTF-MAML3_UBTF_chr17_42286719_ENST00000529383_MAML3_chr4_140812121_ENST00000327122_length(amino acids)=1183AA_BP=640
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQ
KHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYE
VELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMW
NDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAA
EDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQKQ
YKVHLDLWVKLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHT
PGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQ
DLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQ
SPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQ
QQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNI
LTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYA

--------------------------------------------------------------

>96498_96498_6_UBTF-MAML3_UBTF_chr17_42286719_ENST00000529383_MAML3_chr4_140812121_ENST00000509479_length(amino acids)=1622AA_BP=640
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQ
KHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYE
VELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMW
NDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAA
EDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQKQ
YKVHLDLWVKLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHT
PGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQ
DLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQ
SPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQ
QQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNI
LTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYA
ALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAE
QQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPT
SQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTV
QQGAQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPM
VMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFG

--------------------------------------------------------------

>96498_96498_7_UBTF-MAML3_UBTF_chr17_42286720_ENST00000302904_MAML3_chr4_140812121_ENST00000327122_length(amino acids)=1183AA_BP=640
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQ
KHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYE
VELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMW
NDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAA
EDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQKQ
YKVHLDLWVKLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHT
PGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQ
DLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQ
SPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQ
QQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNI
LTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYA

--------------------------------------------------------------

>96498_96498_8_UBTF-MAML3_UBTF_chr17_42286720_ENST00000302904_MAML3_chr4_140812121_ENST00000509479_length(amino acids)=1622AA_BP=640
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQ
KHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYE
VELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMW
NDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAA
EDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQKQ
YKVHLDLWVKLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHT
PGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQ
DLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQ
SPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQ
QQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNI
LTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYA
ALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAE
QQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPT
SQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTV
QQGAQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPM
VMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFG

--------------------------------------------------------------

>96498_96498_9_UBTF-MAML3_UBTF_chr17_42286720_ENST00000526094_MAML3_chr4_140812121_ENST00000327122_length(amino acids)=1146AA_BP=603
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPP
NSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPAS
KKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLP
ESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPM
NGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQKQYKVHLDLWVKLQETVKRKLEGARSPLNGDQQNGACDG
NFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKD
LKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSH
SPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASG
PVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMY
PQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQ

--------------------------------------------------------------

>96498_96498_10_UBTF-MAML3_UBTF_chr17_42286720_ENST00000526094_MAML3_chr4_140812121_ENST00000509479_length(amino acids)=1585AA_BP=603
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPP
NSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPAS
KKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLP
ESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPM
NGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQKQYKVHLDLWVKLQETVKRKLEGARSPLNGDQQNGACDG
NFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKD
LKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSH
SPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASG
PVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMY
PQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQ
QQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGAS
PAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAEQQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAA
VRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQP
ASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAG
QPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQA

--------------------------------------------------------------

>96498_96498_11_UBTF-MAML3_UBTF_chr17_42286720_ENST00000529383_MAML3_chr4_140812121_ENST00000327122_length(amino acids)=1183AA_BP=640
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQ
KHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYE
VELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMW
NDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAA
EDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQKQ
YKVHLDLWVKLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHT
PGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQ
DLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQ
SPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQ
QQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNI
LTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYA

--------------------------------------------------------------

>96498_96498_12_UBTF-MAML3_UBTF_chr17_42286720_ENST00000529383_MAML3_chr4_140812121_ENST00000509479_length(amino acids)=1622AA_BP=640
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQ
KHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYE
VELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMW
NDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAA
EDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQKQ
YKVHLDLWVKLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHT
PGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQ
DLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQ
SPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQ
QQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNI
LTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYA
ALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAE
QQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPT
SQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTV
QQGAQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPM
VMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFG

--------------------------------------------------------------

>96498_96498_13_UBTF-MAML3_UBTF_chr17_42287492_ENST00000302904_MAML3_chr4_140812121_ENST00000327122_length(amino acids)=1090AA_BP=547
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQ
KHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYE
VELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMW
NDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAA
EDQKRYELQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGL
LEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLF
NEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQ
TPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQ
QHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTY
GNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALP

--------------------------------------------------------------

>96498_96498_14_UBTF-MAML3_UBTF_chr17_42287492_ENST00000302904_MAML3_chr4_140812121_ENST00000509479_length(amino acids)=1529AA_BP=547
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQ
KHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYE
VELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMW
NDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAA
EDQKRYELQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGL
LEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLF
NEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQ
TPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQ
QHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTY
GNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALP
SHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAEQQL
QQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQP
GMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQG
AQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPMVMS

--------------------------------------------------------------

>96498_96498_15_UBTF-MAML3_UBTF_chr17_42287492_ENST00000526094_MAML3_chr4_140812121_ENST00000327122_length(amino acids)=1053AA_BP=510
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPP
NSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPAS
KKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLP
ESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYELQETVKRKLEGARSPLNGDQQNGACDGNFS
PTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQ
EPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPF
AHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVA
VPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQA
FNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQ

--------------------------------------------------------------

>96498_96498_16_UBTF-MAML3_UBTF_chr17_42287492_ENST00000526094_MAML3_chr4_140812121_ENST00000509479_length(amino acids)=1492AA_BP=510
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPP
NSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPAS
KKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLP
ESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYELQETVKRKLEGARSPLNGDQQNGACDGNFS
PTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQ
EPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPF
AHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVA
VPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQA
FNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQ
QQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAG
PGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAEQQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRS
QAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASG
QGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPR
LTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYER

--------------------------------------------------------------

>96498_96498_17_UBTF-MAML3_UBTF_chr17_42287492_ENST00000529383_MAML3_chr4_140812121_ENST00000327122_length(amino acids)=1090AA_BP=547
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQ
KHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYE
VELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMW
NDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAA
EDQKRYELQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGL
LEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLF
NEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQ
TPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQ
QHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTY
GNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALP

--------------------------------------------------------------

>96498_96498_18_UBTF-MAML3_UBTF_chr17_42287492_ENST00000529383_MAML3_chr4_140812121_ENST00000509479_length(amino acids)=1529AA_BP=547
MDSWRMNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTL
TELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERN
LARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQ
KHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYE
VELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMW
NDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAA
EDQKRYELQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGL
LEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLF
NEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQ
TPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQ
QHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTY
GNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALP
SHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAEQQL
QQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQP
GMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQG
AQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPMVMS

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:42286720/chr4:140812121)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAML3

Q96JK9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBTFchr17:42286719chr4:140812121ENST00000302904-1721112_180635.0765.0DNA bindingHMG box 1
HgeneUBTFchr17:42286719chr4:140812121ENST00000302904-1721196_264635.0765.0DNA bindingHMG box 2
HgeneUBTFchr17:42286719chr4:140812121ENST00000302904-1721298_362635.0765.0DNA bindingHMG box 3
HgeneUBTFchr17:42286719chr4:140812121ENST00000302904-1721407_475635.0765.0DNA bindingHMG box 4
HgeneUBTFchr17:42286719chr4:140812121ENST00000302904-1721482_549635.0765.0DNA bindingHMG box 5
HgeneUBTFchr17:42286719chr4:140812121ENST00000302904-1721568_634635.0765.0DNA bindingHMG box 6
HgeneUBTFchr17:42286719chr4:140812121ENST00000343638-1620112_180598.0728.0DNA bindingHMG box 1
HgeneUBTFchr17:42286719chr4:140812121ENST00000343638-1620196_264598.0728.0DNA bindingHMG box 2
HgeneUBTFchr17:42286719chr4:140812121ENST00000343638-1620298_362598.0728.0DNA bindingHMG box 3
HgeneUBTFchr17:42286719chr4:140812121ENST00000343638-1620407_475598.0728.0DNA bindingHMG box 4
HgeneUBTFchr17:42286719chr4:140812121ENST00000343638-1620482_549598.0728.0DNA bindingHMG box 5
HgeneUBTFchr17:42286719chr4:140812121ENST00000393606-1620112_180598.0728.0DNA bindingHMG box 1
HgeneUBTFchr17:42286719chr4:140812121ENST00000393606-1620196_264598.0728.0DNA bindingHMG box 2
HgeneUBTFchr17:42286719chr4:140812121ENST00000393606-1620298_362598.0728.0DNA bindingHMG box 3
HgeneUBTFchr17:42286719chr4:140812121ENST00000393606-1620407_475598.0728.0DNA bindingHMG box 4
HgeneUBTFchr17:42286719chr4:140812121ENST00000393606-1620482_549598.0728.0DNA bindingHMG box 5
HgeneUBTFchr17:42286719chr4:140812121ENST00000436088-1721112_180635.0765.0DNA bindingHMG box 1
HgeneUBTFchr17:42286719chr4:140812121ENST00000436088-1721196_264635.0765.0DNA bindingHMG box 2
HgeneUBTFchr17:42286719chr4:140812121ENST00000436088-1721298_362635.0765.0DNA bindingHMG box 3
HgeneUBTFchr17:42286719chr4:140812121ENST00000436088-1721407_475635.0765.0DNA bindingHMG box 4
HgeneUBTFchr17:42286719chr4:140812121ENST00000436088-1721482_549635.0765.0DNA bindingHMG box 5
HgeneUBTFchr17:42286719chr4:140812121ENST00000436088-1721568_634635.0765.0DNA bindingHMG box 6
HgeneUBTFchr17:42286719chr4:140812121ENST00000526094-1519112_180598.0728.0DNA bindingHMG box 1
HgeneUBTFchr17:42286719chr4:140812121ENST00000526094-1519196_264598.0728.0DNA bindingHMG box 2
HgeneUBTFchr17:42286719chr4:140812121ENST00000526094-1519298_362598.0728.0DNA bindingHMG box 3
HgeneUBTFchr17:42286719chr4:140812121ENST00000526094-1519407_475598.0728.0DNA bindingHMG box 4
HgeneUBTFchr17:42286719chr4:140812121ENST00000526094-1519482_549598.0728.0DNA bindingHMG box 5
HgeneUBTFchr17:42286719chr4:140812121ENST00000529383-1620112_180635.0765.0DNA bindingHMG box 1
HgeneUBTFchr17:42286719chr4:140812121ENST00000529383-1620196_264635.0765.0DNA bindingHMG box 2
HgeneUBTFchr17:42286719chr4:140812121ENST00000529383-1620298_362635.0765.0DNA bindingHMG box 3
HgeneUBTFchr17:42286719chr4:140812121ENST00000529383-1620407_475635.0765.0DNA bindingHMG box 4
HgeneUBTFchr17:42286719chr4:140812121ENST00000529383-1620482_549635.0765.0DNA bindingHMG box 5
HgeneUBTFchr17:42286719chr4:140812121ENST00000529383-1620568_634635.0765.0DNA bindingHMG box 6
HgeneUBTFchr17:42286719chr4:140812121ENST00000533177-1620112_180598.0728.0DNA bindingHMG box 1
HgeneUBTFchr17:42286719chr4:140812121ENST00000533177-1620196_264598.0728.0DNA bindingHMG box 2
HgeneUBTFchr17:42286719chr4:140812121ENST00000533177-1620298_362598.0728.0DNA bindingHMG box 3
HgeneUBTFchr17:42286719chr4:140812121ENST00000533177-1620407_475598.0728.0DNA bindingHMG box 4
HgeneUBTFchr17:42286719chr4:140812121ENST00000533177-1620482_549598.0728.0DNA bindingHMG box 5
HgeneUBTFchr17:42286720chr4:140812121ENST00000302904-1721112_180635.0765.0DNA bindingHMG box 1
HgeneUBTFchr17:42286720chr4:140812121ENST00000302904-1721196_264635.0765.0DNA bindingHMG box 2
HgeneUBTFchr17:42286720chr4:140812121ENST00000302904-1721298_362635.0765.0DNA bindingHMG box 3
HgeneUBTFchr17:42286720chr4:140812121ENST00000302904-1721407_475635.0765.0DNA bindingHMG box 4
HgeneUBTFchr17:42286720chr4:140812121ENST00000302904-1721482_549635.0765.0DNA bindingHMG box 5
HgeneUBTFchr17:42286720chr4:140812121ENST00000302904-1721568_634635.0765.0DNA bindingHMG box 6
HgeneUBTFchr17:42286720chr4:140812121ENST00000343638-1620112_180598.0728.0DNA bindingHMG box 1
HgeneUBTFchr17:42286720chr4:140812121ENST00000343638-1620196_264598.0728.0DNA bindingHMG box 2
HgeneUBTFchr17:42286720chr4:140812121ENST00000343638-1620298_362598.0728.0DNA bindingHMG box 3
HgeneUBTFchr17:42286720chr4:140812121ENST00000343638-1620407_475598.0728.0DNA bindingHMG box 4
HgeneUBTFchr17:42286720chr4:140812121ENST00000343638-1620482_549598.0728.0DNA bindingHMG box 5
HgeneUBTFchr17:42286720chr4:140812121ENST00000393606-1620112_180598.0728.0DNA bindingHMG box 1
HgeneUBTFchr17:42286720chr4:140812121ENST00000393606-1620196_264598.0728.0DNA bindingHMG box 2
HgeneUBTFchr17:42286720chr4:140812121ENST00000393606-1620298_362598.0728.0DNA bindingHMG box 3
HgeneUBTFchr17:42286720chr4:140812121ENST00000393606-1620407_475598.0728.0DNA bindingHMG box 4
HgeneUBTFchr17:42286720chr4:140812121ENST00000393606-1620482_549598.0728.0DNA bindingHMG box 5
HgeneUBTFchr17:42286720chr4:140812121ENST00000436088-1721112_180635.0765.0DNA bindingHMG box 1
HgeneUBTFchr17:42286720chr4:140812121ENST00000436088-1721196_264635.0765.0DNA bindingHMG box 2
HgeneUBTFchr17:42286720chr4:140812121ENST00000436088-1721298_362635.0765.0DNA bindingHMG box 3
HgeneUBTFchr17:42286720chr4:140812121ENST00000436088-1721407_475635.0765.0DNA bindingHMG box 4
HgeneUBTFchr17:42286720chr4:140812121ENST00000436088-1721482_549635.0765.0DNA bindingHMG box 5
HgeneUBTFchr17:42286720chr4:140812121ENST00000436088-1721568_634635.0765.0DNA bindingHMG box 6
HgeneUBTFchr17:42286720chr4:140812121ENST00000526094-1519112_180598.0728.0DNA bindingHMG box 1
HgeneUBTFchr17:42286720chr4:140812121ENST00000526094-1519196_264598.0728.0DNA bindingHMG box 2
HgeneUBTFchr17:42286720chr4:140812121ENST00000526094-1519298_362598.0728.0DNA bindingHMG box 3
HgeneUBTFchr17:42286720chr4:140812121ENST00000526094-1519407_475598.0728.0DNA bindingHMG box 4
HgeneUBTFchr17:42286720chr4:140812121ENST00000526094-1519482_549598.0728.0DNA bindingHMG box 5
HgeneUBTFchr17:42286720chr4:140812121ENST00000529383-1620112_180635.0765.0DNA bindingHMG box 1
HgeneUBTFchr17:42286720chr4:140812121ENST00000529383-1620196_264635.0765.0DNA bindingHMG box 2
HgeneUBTFchr17:42286720chr4:140812121ENST00000529383-1620298_362635.0765.0DNA bindingHMG box 3
HgeneUBTFchr17:42286720chr4:140812121ENST00000529383-1620407_475635.0765.0DNA bindingHMG box 4
HgeneUBTFchr17:42286720chr4:140812121ENST00000529383-1620482_549635.0765.0DNA bindingHMG box 5
HgeneUBTFchr17:42286720chr4:140812121ENST00000529383-1620568_634635.0765.0DNA bindingHMG box 6
HgeneUBTFchr17:42286720chr4:140812121ENST00000533177-1620112_180598.0728.0DNA bindingHMG box 1
HgeneUBTFchr17:42286720chr4:140812121ENST00000533177-1620196_264598.0728.0DNA bindingHMG box 2
HgeneUBTFchr17:42286720chr4:140812121ENST00000533177-1620298_362598.0728.0DNA bindingHMG box 3
HgeneUBTFchr17:42286720chr4:140812121ENST00000533177-1620407_475598.0728.0DNA bindingHMG box 4
HgeneUBTFchr17:42286720chr4:140812121ENST00000533177-1620482_549598.0728.0DNA bindingHMG box 5
HgeneUBTFchr17:42287492chr4:140812121ENST00000302904-1521112_180542.0765.0DNA bindingHMG box 1
HgeneUBTFchr17:42287492chr4:140812121ENST00000302904-1521196_264542.0765.0DNA bindingHMG box 2
HgeneUBTFchr17:42287492chr4:140812121ENST00000302904-1521298_362542.0765.0DNA bindingHMG box 3
HgeneUBTFchr17:42287492chr4:140812121ENST00000302904-1521407_475542.0765.0DNA bindingHMG box 4
HgeneUBTFchr17:42287492chr4:140812121ENST00000343638-1420112_180505.0728.0DNA bindingHMG box 1
HgeneUBTFchr17:42287492chr4:140812121ENST00000343638-1420196_264505.0728.0DNA bindingHMG box 2
HgeneUBTFchr17:42287492chr4:140812121ENST00000343638-1420298_362505.0728.0DNA bindingHMG box 3
HgeneUBTFchr17:42287492chr4:140812121ENST00000343638-1420407_475505.0728.0DNA bindingHMG box 4
HgeneUBTFchr17:42287492chr4:140812121ENST00000393606-1420112_180505.0728.0DNA bindingHMG box 1
HgeneUBTFchr17:42287492chr4:140812121ENST00000393606-1420196_264505.0728.0DNA bindingHMG box 2
HgeneUBTFchr17:42287492chr4:140812121ENST00000393606-1420298_362505.0728.0DNA bindingHMG box 3
HgeneUBTFchr17:42287492chr4:140812121ENST00000393606-1420407_475505.0728.0DNA bindingHMG box 4
HgeneUBTFchr17:42287492chr4:140812121ENST00000436088-1521112_180542.0765.0DNA bindingHMG box 1
HgeneUBTFchr17:42287492chr4:140812121ENST00000436088-1521196_264542.0765.0DNA bindingHMG box 2
HgeneUBTFchr17:42287492chr4:140812121ENST00000436088-1521298_362542.0765.0DNA bindingHMG box 3
HgeneUBTFchr17:42287492chr4:140812121ENST00000436088-1521407_475542.0765.0DNA bindingHMG box 4
HgeneUBTFchr17:42287492chr4:140812121ENST00000526094-1319112_180505.0728.0DNA bindingHMG box 1
HgeneUBTFchr17:42287492chr4:140812121ENST00000526094-1319196_264505.0728.0DNA bindingHMG box 2
HgeneUBTFchr17:42287492chr4:140812121ENST00000526094-1319298_362505.0728.0DNA bindingHMG box 3
HgeneUBTFchr17:42287492chr4:140812121ENST00000526094-1319407_475505.0728.0DNA bindingHMG box 4
HgeneUBTFchr17:42287492chr4:140812121ENST00000529383-1420112_180542.0765.0DNA bindingHMG box 1
HgeneUBTFchr17:42287492chr4:140812121ENST00000529383-1420196_264542.0765.0DNA bindingHMG box 2
HgeneUBTFchr17:42287492chr4:140812121ENST00000529383-1420298_362542.0765.0DNA bindingHMG box 3
HgeneUBTFchr17:42287492chr4:140812121ENST00000529383-1420407_475542.0765.0DNA bindingHMG box 4
HgeneUBTFchr17:42287492chr4:140812121ENST00000533177-1420112_180505.0728.0DNA bindingHMG box 1
HgeneUBTFchr17:42287492chr4:140812121ENST00000533177-1420196_264505.0728.0DNA bindingHMG box 2
HgeneUBTFchr17:42287492chr4:140812121ENST00000533177-1420298_362505.0728.0DNA bindingHMG box 3
HgeneUBTFchr17:42287492chr4:140812121ENST00000533177-1420407_475505.0728.0DNA bindingHMG box 4
TgeneMAML3chr17:42286719chr4:140812121ENST0000050947905467_968156.01139.0Compositional biasNote=Gln-rich
TgeneMAML3chr17:42286719chr4:140812121ENST0000050947905548_595156.01139.0Compositional biasNote=Asn-rich
TgeneMAML3chr17:42286720chr4:140812121ENST0000050947905467_968156.01139.0Compositional biasNote=Gln-rich
TgeneMAML3chr17:42286720chr4:140812121ENST0000050947905548_595156.01139.0Compositional biasNote=Asn-rich
TgeneMAML3chr17:42287492chr4:140812121ENST0000050947905467_968156.01139.0Compositional biasNote=Gln-rich
TgeneMAML3chr17:42287492chr4:140812121ENST0000050947905548_595156.01139.0Compositional biasNote=Asn-rich

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBTFchr17:42286719chr4:140812121ENST00000302904-1721675_764635.0765.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286719chr4:140812121ENST00000343638-1620675_764598.0728.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286719chr4:140812121ENST00000393606-1620675_764598.0728.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286719chr4:140812121ENST00000436088-1721675_764635.0765.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286719chr4:140812121ENST00000526094-1519675_764598.0728.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286719chr4:140812121ENST00000529383-1620675_764635.0765.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286719chr4:140812121ENST00000533177-1620675_764598.0728.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286720chr4:140812121ENST00000302904-1721675_764635.0765.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286720chr4:140812121ENST00000343638-1620675_764598.0728.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286720chr4:140812121ENST00000393606-1620675_764598.0728.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286720chr4:140812121ENST00000436088-1721675_764635.0765.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286720chr4:140812121ENST00000526094-1519675_764598.0728.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286720chr4:140812121ENST00000529383-1620675_764635.0765.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286720chr4:140812121ENST00000533177-1620675_764598.0728.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42287492chr4:140812121ENST00000302904-1521675_764542.0765.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42287492chr4:140812121ENST00000343638-1420675_764505.0728.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42287492chr4:140812121ENST00000393606-1420675_764505.0728.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42287492chr4:140812121ENST00000436088-1521675_764542.0765.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42287492chr4:140812121ENST00000526094-1319675_764505.0728.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42287492chr4:140812121ENST00000529383-1420675_764542.0765.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42287492chr4:140812121ENST00000533177-1420675_764505.0728.0Compositional biasNote=Asp/Glu/Ser-rich (acidic)
HgeneUBTFchr17:42286719chr4:140812121ENST00000343638-1620568_634598.0728.0DNA bindingHMG box 6
HgeneUBTFchr17:42286719chr4:140812121ENST00000393606-1620568_634598.0728.0DNA bindingHMG box 6
HgeneUBTFchr17:42286719chr4:140812121ENST00000526094-1519568_634598.0728.0DNA bindingHMG box 6
HgeneUBTFchr17:42286719chr4:140812121ENST00000533177-1620568_634598.0728.0DNA bindingHMG box 6
HgeneUBTFchr17:42286720chr4:140812121ENST00000343638-1620568_634598.0728.0DNA bindingHMG box 6
HgeneUBTFchr17:42286720chr4:140812121ENST00000393606-1620568_634598.0728.0DNA bindingHMG box 6
HgeneUBTFchr17:42286720chr4:140812121ENST00000526094-1519568_634598.0728.0DNA bindingHMG box 6
HgeneUBTFchr17:42286720chr4:140812121ENST00000533177-1620568_634598.0728.0DNA bindingHMG box 6
HgeneUBTFchr17:42287492chr4:140812121ENST00000302904-1521482_549542.0765.0DNA bindingHMG box 5
HgeneUBTFchr17:42287492chr4:140812121ENST00000302904-1521568_634542.0765.0DNA bindingHMG box 6
HgeneUBTFchr17:42287492chr4:140812121ENST00000343638-1420482_549505.0728.0DNA bindingHMG box 5
HgeneUBTFchr17:42287492chr4:140812121ENST00000343638-1420568_634505.0728.0DNA bindingHMG box 6
HgeneUBTFchr17:42287492chr4:140812121ENST00000393606-1420482_549505.0728.0DNA bindingHMG box 5
HgeneUBTFchr17:42287492chr4:140812121ENST00000393606-1420568_634505.0728.0DNA bindingHMG box 6
HgeneUBTFchr17:42287492chr4:140812121ENST00000436088-1521482_549542.0765.0DNA bindingHMG box 5
HgeneUBTFchr17:42287492chr4:140812121ENST00000436088-1521568_634542.0765.0DNA bindingHMG box 6
HgeneUBTFchr17:42287492chr4:140812121ENST00000526094-1319482_549505.0728.0DNA bindingHMG box 5
HgeneUBTFchr17:42287492chr4:140812121ENST00000526094-1319568_634505.0728.0DNA bindingHMG box 6
HgeneUBTFchr17:42287492chr4:140812121ENST00000529383-1420482_549542.0765.0DNA bindingHMG box 5
HgeneUBTFchr17:42287492chr4:140812121ENST00000529383-1420568_634542.0765.0DNA bindingHMG box 6
HgeneUBTFchr17:42287492chr4:140812121ENST00000533177-1420482_549505.0728.0DNA bindingHMG box 5
HgeneUBTFchr17:42287492chr4:140812121ENST00000533177-1420568_634505.0728.0DNA bindingHMG box 6


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
UBTF_pLDDT.png
all structure
all structure
MAML3_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
UBTF
MAML3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to UBTF-MAML3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to UBTF-MAML3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource