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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:UIMC1-DBN1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: UIMC1-DBN1
	FusionPDB ID: 96737
	FusionGDB2.0 ID: 96737
		Hgene	Tgene
	Gene symbol	UIMC1	DBN1
	Gene ID	51720	1627
	Gene name	ubiquitin interaction motif containing 1	drebrin 1
	Synonyms	RAP80\|X2HRIP110	D0S117E
	Cytomap	5q35.2	5q35.3
	Type of gene	protein-coding	protein-coding
	Description	BRCA1-A complex subunit RAP80receptor-associated protein 80retinoid X receptor-interacting protein 110	drebrindevelopmentally-regulated brain proteindrebrin Adrebrin Edrebrin E2
	Modification date	20200327	20200320
	UniProtAcc	.	Q16643
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000377219, ENST00000377227, ENST00000506128, ENST00000511320, ENST00000503273,	ENST00000393563, ENST00000512501, ENST00000292385, ENST00000309007, ENST00000393565,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 7 X 7=441	10 X 9 X 7=630
	# samples	10	10
	** MAII score	log2(10/441*10)=-2.1407786557828 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/630*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: UIMC1 [Title/Abstract] AND DBN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	UIMC1(176370336)-DBN1(176895900), # samples:3
Anticipated loss of major functional domain due to fusion event.	UIMC1-DBN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UIMC1-DBN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UIMC1-DBN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. UIMC1-DBN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UIMC1	GO:0045892	negative regulation of transcription, DNA-templated	12080054
Tgene	DBN1	GO:0051220	cytoplasmic sequestering of protein	28966017

Fusion gene breakpoints across UIMC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DBN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ACC	TCGA-OR-A5J1-01A	UIMC1	chr5	176370336	-	DBN1	chr5	176895900	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000377227	UIMC1	chr5	176370336	-	ENST00000309007	DBN1	chr5	176895900	-	4419	1730	1701	3593	630
ENST00000377227	UIMC1	chr5	176370336	-	ENST00000292385	DBN1	chr5	176895900	-	4100	1730	1701	3593	630
ENST00000377227	UIMC1	chr5	176370336	-	ENST00000393565	DBN1	chr5	176895900	-	4229	1730	1701	3731	676
ENST00000377219	UIMC1	chr5	176370336	-	ENST00000309007	DBN1	chr5	176895900	-	4453	1764	1735	3627	630
ENST00000377219	UIMC1	chr5	176370336	-	ENST00000292385	DBN1	chr5	176895900	-	4134	1764	1735	3627	630
ENST00000377219	UIMC1	chr5	176370336	-	ENST00000393565	DBN1	chr5	176895900	-	4263	1764	1735	3765	676
ENST00000506128	UIMC1	chr5	176370336	-	ENST00000309007	DBN1	chr5	176895900	-	3839	1150	1121	3013	630
ENST00000506128	UIMC1	chr5	176370336	-	ENST00000292385	DBN1	chr5	176895900	-	3520	1150	1121	3013	630
ENST00000506128	UIMC1	chr5	176370336	-	ENST00000393565	DBN1	chr5	176895900	-	3649	1150	1121	3151	676
ENST00000511320	UIMC1	chr5	176370336	-	ENST00000309007	DBN1	chr5	176895900	-	4396	1707	1678	3570	630
ENST00000511320	UIMC1	chr5	176370336	-	ENST00000292385	DBN1	chr5	176895900	-	4077	1707	1678	3570	630
ENST00000511320	UIMC1	chr5	176370336	-	ENST00000393565	DBN1	chr5	176895900	-	4206	1707	1678	3708	676

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000377227	ENST00000309007	UIMC1	chr5	176370336	-	DBN1	chr5	176895900	-	0.011123928	0.98887604
ENST00000377227	ENST00000292385	UIMC1	chr5	176370336	-	DBN1	chr5	176895900	-	0.013525403	0.9864746
ENST00000377227	ENST00000393565	UIMC1	chr5	176370336	-	DBN1	chr5	176895900	-	0.011816654	0.9881833
ENST00000377219	ENST00000309007	UIMC1	chr5	176370336	-	DBN1	chr5	176895900	-	0.010644302	0.9893556
ENST00000377219	ENST00000292385	UIMC1	chr5	176370336	-	DBN1	chr5	176895900	-	0.012943139	0.9870568
ENST00000377219	ENST00000393565	UIMC1	chr5	176370336	-	DBN1	chr5	176895900	-	0.011304744	0.9886953
ENST00000506128	ENST00000309007	UIMC1	chr5	176370336	-	DBN1	chr5	176895900	-	0.011460037	0.98854
ENST00000506128	ENST00000292385	UIMC1	chr5	176370336	-	DBN1	chr5	176895900	-	0.012914216	0.98708576
ENST00000506128	ENST00000393565	UIMC1	chr5	176370336	-	DBN1	chr5	176895900	-	0.011355712	0.98864424
ENST00000511320	ENST00000309007	UIMC1	chr5	176370336	-	DBN1	chr5	176895900	-	0.011644222	0.98835576
ENST00000511320	ENST00000292385	UIMC1	chr5	176370336	-	DBN1	chr5	176895900	-	0.014423829	0.98557615
ENST00000511320	ENST00000393565	UIMC1	chr5	176370336	-	DBN1	chr5	176895900	-	0.012394626	0.98760533

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>96737_96737_1_UIMC1-DBN1_UIMC1_chr5_176370336_ENST00000377219_DBN1_chr5_176895900_ENST00000292385_length(amino acids)=630AA_BP=9
MQWSDGGRYRALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFF
QGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKA
LDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN
PREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQE
PSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVP
PAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQT
PTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD

--------------------------------------------------------------

>96737_96737_2_UIMC1-DBN1_UIMC1_chr5_176370336_ENST00000377219_DBN1_chr5_176895900_ENST00000309007_length(amino acids)=630AA_BP=9
MQWSDGGRYRALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFF
QGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKA
LDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN
PREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQE
PSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVP
PAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQT
PTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD

--------------------------------------------------------------

>96737_96737_3_UIMC1-DBN1_UIMC1_chr5_176370336_ENST00000377219_DBN1_chr5_176895900_ENST00000393565_length(amino acids)=676AA_BP=9
MQWSDGGRYRALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFF
QGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKA
LDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN
PREFFKQQERVASASAGSCDVPSPFNHRPGRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPCSHLDSHRRMAPTPI
PTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMF
MESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLD
EVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQE

--------------------------------------------------------------

>96737_96737_4_UIMC1-DBN1_UIMC1_chr5_176370336_ENST00000377227_DBN1_chr5_176895900_ENST00000292385_length(amino acids)=630AA_BP=9
MQWSDGGRYRALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFF
QGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKA
LDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN
PREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQE
PSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVP
PAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQT
PTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD

--------------------------------------------------------------

>96737_96737_5_UIMC1-DBN1_UIMC1_chr5_176370336_ENST00000377227_DBN1_chr5_176895900_ENST00000309007_length(amino acids)=630AA_BP=9
MQWSDGGRYRALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFF
QGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKA
LDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN
PREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQE
PSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVP
PAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQT
PTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD

--------------------------------------------------------------

>96737_96737_6_UIMC1-DBN1_UIMC1_chr5_176370336_ENST00000377227_DBN1_chr5_176895900_ENST00000393565_length(amino acids)=676AA_BP=9
MQWSDGGRYRALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFF
QGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKA
LDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN
PREFFKQQERVASASAGSCDVPSPFNHRPGRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPCSHLDSHRRMAPTPI
PTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMF
MESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLD
EVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQE

--------------------------------------------------------------

>96737_96737_7_UIMC1-DBN1_UIMC1_chr5_176370336_ENST00000506128_DBN1_chr5_176895900_ENST00000292385_length(amino acids)=630AA_BP=9
MQWSDGGRYRALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFF
QGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKA
LDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN
PREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQE
PSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVP
PAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQT
PTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD

--------------------------------------------------------------

>96737_96737_8_UIMC1-DBN1_UIMC1_chr5_176370336_ENST00000506128_DBN1_chr5_176895900_ENST00000309007_length(amino acids)=630AA_BP=9
MQWSDGGRYRALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFF
QGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKA
LDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN
PREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQE
PSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVP
PAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQT
PTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD

--------------------------------------------------------------

>96737_96737_9_UIMC1-DBN1_UIMC1_chr5_176370336_ENST00000506128_DBN1_chr5_176895900_ENST00000393565_length(amino acids)=676AA_BP=9
MQWSDGGRYRALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFF
QGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKA
LDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN
PREFFKQQERVASASAGSCDVPSPFNHRPGRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPCSHLDSHRRMAPTPI
PTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMF
MESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLD
EVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQE

--------------------------------------------------------------

>96737_96737_10_UIMC1-DBN1_UIMC1_chr5_176370336_ENST00000511320_DBN1_chr5_176895900_ENST00000292385_length(amino acids)=630AA_BP=9
MQWSDGGRYRALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFF
QGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKA
LDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN
PREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQE
PSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVP
PAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQT
PTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD

--------------------------------------------------------------

>96737_96737_11_UIMC1-DBN1_UIMC1_chr5_176370336_ENST00000511320_DBN1_chr5_176895900_ENST00000309007_length(amino acids)=630AA_BP=9
MQWSDGGRYRALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFF
QGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKA
LDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN
PREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQE
PSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVP
PAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQT
PTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD

--------------------------------------------------------------

>96737_96737_12_UIMC1-DBN1_UIMC1_chr5_176370336_ENST00000511320_DBN1_chr5_176895900_ENST00000393565_length(amino acids)=676AA_BP=9
MQWSDGGRYRALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFF
QGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKA
LDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDN
PREFFKQQERVASASAGSCDVPSPFNHRPGRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPCSHLDSHRRMAPTPI
PTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMF
MESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLD
EVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQE

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:176370336/chr5:176895900)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DBN1 Q16643
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250\|UniProtKB:Q9QXS6, ECO:0000269\|PubMed:20215400}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000377227

81_108

532.3333333333334

720.0

Compositional bias

Note=Glu-rich

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000506128

81_108

366.3333333333333

554.0

Compositional bias

Note=Glu-rich

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000511320

81_108

532.3333333333334

720.0

Compositional bias

Note=Glu-rich

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000377227

105_124

532.3333333333334

720.0

Domain

UIM 2

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000377227

80_99

532.3333333333334

720.0

Domain

UIM 1

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000506128

105_124

366.3333333333333

554.0

Domain

UIM 2

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000506128

80_99

366.3333333333333

554.0

Domain

UIM 1

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000511320

105_124

532.3333333333334

720.0

Domain

UIM 2

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000511320

80_99

532.3333333333334

720.0

Domain

UIM 1

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000377227

60_78

532.3333333333334

720.0

Motif

Note=LR motif

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000506128

60_78

366.3333333333333

554.0

Motif

Note=LR motif

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000511320

60_78

532.3333333333334

720.0

Motif

Note=LR motif

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000377227

1_101

532.3333333333334

720.0

Region

Note=Necessary for transcriptional repression

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000377227

270_400

532.3333333333334

720.0

Region

Note=AIR

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000506128

1_101

366.3333333333333

554.0

Region

Note=Necessary for transcriptional repression

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000511320

1_101

532.3333333333334

720.0

Region

Note=Necessary for transcriptional repression

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000511320

270_400

532.3333333333334

720.0

Region

Note=AIR

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000377227

502_529

532.3333333333334

720.0

Zinc finger

UBZ4-type

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000511320

502_529

532.3333333333334

720.0

Zinc finger

UBZ4-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000377227

505_582

532.3333333333334

720.0

Region

Note=Zinc-finger-like region

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000506128

270_400

366.3333333333333

554.0

Region

Note=AIR

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000506128

505_582

366.3333333333333

554.0

Region

Note=Zinc-finger-like region

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000511320

505_582

532.3333333333334

720.0

Region

Note=Zinc-finger-like region

Hgene

UIMC1

chr5:176370336

chr5:176895900

ENST00000506128

502_529

366.3333333333333

554.0

Zinc finger

UBZ4-type

Tgene

DBN1

chr5:176370336

chr5:176895900

ENST00000292385

3_134

30.666666666666668

652.0

Domain

ADF-H

Tgene

DBN1

chr5:176370336

chr5:176895900

ENST00000309007

3_134

28.666666666666668

650.0

Domain

ADF-H

Tgene

DBN1

chr5:176370336

chr5:176895900

ENST00000393565

3_134

28.666666666666668

696.0

Domain

ADF-H

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
UIMC1
DBN1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to UIMC1-DBN1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to UIMC1-DBN1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source