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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:UIMC1-MXD3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: UIMC1-MXD3
	FusionPDB ID: 96741
	FusionGDB2.0 ID: 96741
		Hgene	Tgene
	Gene symbol	UIMC1	MXD3
	Gene ID	51720	83463
	Gene name	ubiquitin interaction motif containing 1	MAX dimerization protein 3
	Synonyms	RAP80\|X2HRIP110	BHLHC13\|MAD3\|MYX
	Cytomap	5q35.2	5q35.3
	Type of gene	protein-coding	protein-coding
	Description	BRCA1-A complex subunit RAP80receptor-associated protein 80retinoid X receptor-interacting protein 110	max dimerization protein 3Max-associated protein 3Max-interacting transcriptional repressor MAD3class C basic helix-loop-helix protein 13max dimerizer 3
	Modification date	20200327	20200313
	UniProtAcc	.	Q9BW11
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000377219, ENST00000377227, ENST00000506128, ENST00000511320, ENST00000503273,	ENST00000423571, ENST00000427908, ENST00000439742, ENST00000513063,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 7 X 7=441	3 X 4 X 4=48
	# samples	10	4
	** MAII score	log2(10/441*10)=-2.1407786557828 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: UIMC1 [Title/Abstract] AND MXD3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	UIMC1(176397743)-MXD3(176734965), # samples:3
Anticipated loss of major functional domain due to fusion event.	UIMC1-MXD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UIMC1-MXD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UIMC1-MXD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. UIMC1-MXD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. UIMC1-MXD3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. UIMC1-MXD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. UIMC1-MXD3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. UIMC1-MXD3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UIMC1	GO:0045892	negative regulation of transcription, DNA-templated	12080054

Fusion gene breakpoints across UIMC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MXD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-BC-A112-01A	UIMC1	chr5	176397743	-	MXD3	chr5	176734965	-
ChimerDB4	PRAD	TCGA-YJ-A8SW-01A	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000377227	UIMC1	chr5	176409470	-	ENST00000427908	MXD3	chr5	176738485	-	2411	280	303	791	162
ENST00000377227	UIMC1	chr5	176409470	-	ENST00000423571	MXD3	chr5	176738485	-	1679	280	303	1376	357
ENST00000377227	UIMC1	chr5	176409470	-	ENST00000439742	MXD3	chr5	176738485	-	1214	280	303	830	175
ENST00000377227	UIMC1	chr5	176409470	-	ENST00000513063	MXD3	chr5	176738485	-	984	280	303	830	175
ENST00000377219	UIMC1	chr5	176409470	-	ENST00000427908	MXD3	chr5	176738485	-	2445	314	337	825	162
ENST00000377219	UIMC1	chr5	176409470	-	ENST00000423571	MXD3	chr5	176738485	-	1713	314	337	1410	357
ENST00000377219	UIMC1	chr5	176409470	-	ENST00000439742	MXD3	chr5	176738485	-	1248	314	337	864	175
ENST00000377219	UIMC1	chr5	176409470	-	ENST00000513063	MXD3	chr5	176738485	-	1018	314	337	864	175
ENST00000506128	UIMC1	chr5	176409470	-	ENST00000427908	MXD3	chr5	176738485	-	2329	198	221	709	162
ENST00000506128	UIMC1	chr5	176409470	-	ENST00000423571	MXD3	chr5	176738485	-	1597	198	221	1294	357
ENST00000506128	UIMC1	chr5	176409470	-	ENST00000439742	MXD3	chr5	176738485	-	1132	198	221	748	175
ENST00000506128	UIMC1	chr5	176409470	-	ENST00000513063	MXD3	chr5	176738485	-	902	198	221	748	175
ENST00000511320	UIMC1	chr5	176409470	-	ENST00000427908	MXD3	chr5	176738485	-	2388	257	280	768	162
ENST00000511320	UIMC1	chr5	176409470	-	ENST00000423571	MXD3	chr5	176738485	-	1656	257	280	1353	357
ENST00000511320	UIMC1	chr5	176409470	-	ENST00000439742	MXD3	chr5	176738485	-	1191	257	280	807	175
ENST00000511320	UIMC1	chr5	176409470	-	ENST00000513063	MXD3	chr5	176738485	-	961	257	280	807	175

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000377227	ENST00000427908	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.15900657	0.8409934
ENST00000377227	ENST00000423571	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.32004952	0.6799505
ENST00000377227	ENST00000439742	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.030143397	0.9698566
ENST00000377227	ENST00000513063	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.02589187	0.9741081
ENST00000377219	ENST00000427908	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.13455182	0.86544824
ENST00000377219	ENST00000423571	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.31423846	0.6857615
ENST00000377219	ENST00000439742	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.016701493	0.9832985
ENST00000377219	ENST00000513063	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.01605018	0.9839498
ENST00000506128	ENST00000427908	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.10862265	0.8913774
ENST00000506128	ENST00000423571	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.33429345	0.6657065
ENST00000506128	ENST00000439742	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.029035522	0.9709645
ENST00000506128	ENST00000513063	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.02157747	0.9784225
ENST00000511320	ENST00000427908	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.07650619	0.92349386
ENST00000511320	ENST00000423571	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.3728644	0.62713563
ENST00000511320	ENST00000439742	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.02721059	0.9727894
ENST00000511320	ENST00000513063	UIMC1	chr5	176409470	-	MXD3	chr5	176738485	-	0.02295058	0.9770494

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>96741_96741_1_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000377219_MXD3_chr5_176738485_ENST00000423571_length(amino acids)=357AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE
RLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQGECPEAEGLCGPRGEPGLLTGPLPAQRSWRWMWRAWCLGVRPS
CCGASSPARSTATRTAAAPGYDVPHPGRASALYSCQAHLPGRSPPQAFRAARSHLLEWTKRTLVWEQVLPKHPAAGCQAGPLEGKGQDSS

--------------------------------------------------------------

>96741_96741_2_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000377219_MXD3_chr5_176738485_ENST00000427908_length(amino acids)=162AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE

--------------------------------------------------------------

>96741_96741_3_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000377219_MXD3_chr5_176738485_ENST00000439742_length(amino acids)=175AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE

--------------------------------------------------------------

>96741_96741_4_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000377219_MXD3_chr5_176738485_ENST00000513063_length(amino acids)=175AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE

--------------------------------------------------------------

>96741_96741_5_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000377227_MXD3_chr5_176738485_ENST00000423571_length(amino acids)=357AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE
RLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQGECPEAEGLCGPRGEPGLLTGPLPAQRSWRWMWRAWCLGVRPS
CCGASSPARSTATRTAAAPGYDVPHPGRASALYSCQAHLPGRSPPQAFRAARSHLLEWTKRTLVWEQVLPKHPAAGCQAGPLEGKGQDSS

--------------------------------------------------------------

>96741_96741_6_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000377227_MXD3_chr5_176738485_ENST00000427908_length(amino acids)=162AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE

--------------------------------------------------------------

>96741_96741_7_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000377227_MXD3_chr5_176738485_ENST00000439742_length(amino acids)=175AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE

--------------------------------------------------------------

>96741_96741_8_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000377227_MXD3_chr5_176738485_ENST00000513063_length(amino acids)=175AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE

--------------------------------------------------------------

>96741_96741_9_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000506128_MXD3_chr5_176738485_ENST00000423571_length(amino acids)=357AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE
RLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQGECPEAEGLCGPRGEPGLLTGPLPAQRSWRWMWRAWCLGVRPS
CCGASSPARSTATRTAAAPGYDVPHPGRASALYSCQAHLPGRSPPQAFRAARSHLLEWTKRTLVWEQVLPKHPAAGCQAGPLEGKGQDSS

--------------------------------------------------------------

>96741_96741_10_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000506128_MXD3_chr5_176738485_ENST00000427908_length(amino acids)=162AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE

--------------------------------------------------------------

>96741_96741_11_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000506128_MXD3_chr5_176738485_ENST00000439742_length(amino acids)=175AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE

--------------------------------------------------------------

>96741_96741_12_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000506128_MXD3_chr5_176738485_ENST00000513063_length(amino acids)=175AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE

--------------------------------------------------------------

>96741_96741_13_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000511320_MXD3_chr5_176738485_ENST00000423571_length(amino acids)=357AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE
RLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQGECPEAEGLCGPRGEPGLLTGPLPAQRSWRWMWRAWCLGVRPS
CCGASSPARSTATRTAAAPGYDVPHPGRASALYSCQAHLPGRSPPQAFRAARSHLLEWTKRTLVWEQVLPKHPAAGCQAGPLEGKGQDSS

--------------------------------------------------------------

>96741_96741_14_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000511320_MXD3_chr5_176738485_ENST00000427908_length(amino acids)=162AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE

--------------------------------------------------------------

>96741_96741_15_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000511320_MXD3_chr5_176738485_ENST00000439742_length(amino acids)=175AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE

--------------------------------------------------------------

>96741_96741_16_UIMC1-MXD3_UIMC1_chr5_176409470_ENST00000511320_MXD3_chr5_176738485_ENST00000513063_length(amino acids)=175AA_BP=
MCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:176397743/chr5:176734965)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MXD3 Q9BW11
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MXD3

chr5:176409470

chr5:176738485

ENST00000427908

57_109

23.333333333333332

194.0

Domain

bHLH

Tgene

MXD3

chr5:176409470

chr5:176738485

ENST00000439742

57_109

23.333333333333332

207.0

Domain

bHLH

Tgene

MXD3

chr5:176409470

chr5:176738485

ENST00000513063

57_109

23.333333333333332

207.0

Domain

bHLH

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000377227

81_108

49.0

720.0

Compositional bias

Note=Glu-rich

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000506128

81_108

49.0

554.0

Compositional bias

Note=Glu-rich

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000511320

81_108

49.0

720.0

Compositional bias

Note=Glu-rich

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000377227

105_124

49.0

720.0

Domain

UIM 2

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000377227

80_99

49.0

720.0

Domain

UIM 1

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000506128

105_124

49.0

554.0

Domain

UIM 2

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000506128

80_99

49.0

554.0

Domain

UIM 1

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000511320

105_124

49.0

720.0

Domain

UIM 2

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000511320

80_99

49.0

720.0

Domain

UIM 1

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000377227

60_78

49.0

720.0

Motif

Note=LR motif

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000506128

60_78

49.0

554.0

Motif

Note=LR motif

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000511320

60_78

49.0

720.0

Motif

Note=LR motif

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000377227

1_101

49.0

720.0

Region

Note=Necessary for transcriptional repression

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000377227

270_400

49.0

720.0

Region

Note=AIR

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000377227

505_582

49.0

720.0

Region

Note=Zinc-finger-like region

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000506128

1_101

49.0

554.0

Region

Note=Necessary for transcriptional repression

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000506128

270_400

49.0

554.0

Region

Note=AIR

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000506128

505_582

49.0

554.0

Region

Note=Zinc-finger-like region

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000511320

1_101

49.0

720.0

Region

Note=Necessary for transcriptional repression

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000511320

270_400

49.0

720.0

Region

Note=AIR

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000511320

505_582

49.0

720.0

Region

Note=Zinc-finger-like region

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000377227

502_529

49.0

720.0

Zinc finger

UBZ4-type

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000506128

502_529

49.0

554.0

Zinc finger

UBZ4-type

Hgene

UIMC1

chr5:176409470

chr5:176738485

ENST00000511320

502_529

49.0

720.0

Zinc finger

UBZ4-type

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
UIMC1
MXD3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	MXD3	chr5:176409470	chr5:176738485	ENST00000427908		0	6	8_25	23.333333333333332	194.0	SIN3A and SIN3B
Tgene	MXD3	chr5:176409470	chr5:176738485	ENST00000439742		0	6	8_25	23.333333333333332	207.0	SIN3A and SIN3B
Tgene	MXD3	chr5:176409470	chr5:176738485	ENST00000513063		1	7	8_25	23.333333333333332	207.0	SIN3A and SIN3B

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Related Drugs to UIMC1-MXD3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to UIMC1-MXD3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source