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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ULK1-FBXW8

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ULK1-FBXW8
FusionPDB ID: 96750
FusionGDB2.0 ID: 96750
HgeneTgene
Gene symbol

ULK1

FBXW8

Gene ID

8408

26259

Gene nameunc-51 like autophagy activating kinase 1F-box and WD repeat domain containing 8
SynonymsATG1|ATG1A|UNC51|Unc51.1|hATG1FBW6|FBW8|FBX29|FBXO29|FBXW6
Cytomap

12q24.33

12q24.22

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase ULK1ATG1 autophagy related 1 homologautophagy-related protein 1 homologF-box/WD repeat-containing protein 8F-box and WD-40 domain protein 8F-box and WD-40 domain-containing protein 8F-box only protein 29
Modification date2020032720200313
UniProtAcc.

Q8N3Y1

Ensembl transtripts involved in fusion geneENST idsENST00000321867, ENST00000540647, 
ENST00000551773, ENST00000309909, 
ENST00000455858, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 9 X 7=50412 X 12 X 4=576
# samples 1114
** MAII scorelog2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/576*10)=-2.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ULK1 [Title/Abstract] AND FBXW8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ULK1(132403929)-FBXW8(117461952), # samples:3
Anticipated loss of major functional domain due to fusion event.ULK1-FBXW8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ULK1-FBXW8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ULK1-FBXW8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ULK1-FBXW8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ULK1-FBXW8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ULK1-FBXW8 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ULK1-FBXW8 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ULK1-FBXW8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneULK1

GO:0006914

autophagy

18936157

HgeneULK1

GO:0018105

peptidyl-serine phosphorylation

25126726|27103069

HgeneULK1

GO:0018107

peptidyl-threonine phosphorylation

27103069

HgeneULK1

GO:0031333

negative regulation of protein complex assembly

25126726

HgeneULK1

GO:0046777

protein autophosphorylation

18936157

TgeneFBXW8

GO:0008283

cell proliferation

24362026

TgeneFBXW8

GO:0016567

protein ubiquitination

18498745|24362026

TgeneFBXW8

GO:0050775

positive regulation of dendrite morphogenesis

21572988


check buttonFusion gene breakpoints across ULK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBXW8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-34-5232-01AULK1chr12

132403929

-FBXW8chr12

117461952

+
ChimerDB4LUSCTCGA-34-5232-01AULK1chr12

132403929

+FBXW8chr12

117461952

+
ChimerDB4LUSCTCGA-34-5232ULK1chr12

132402099

+FBXW8chr12

117461952

+
ChimerDB4LUSCTCGA-34-5232ULK1chr12

132403929

+FBXW8chr12

117461951

+
ChimerDB4LUSCTCGA-34-5232ULK1chr12

132403929

+FBXW8chr12

117461952

+
ChimerDB4LUSCTCGA-34-5232ULK1chr12

132404135

+FBXW8chr12

117461952

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000321867ULK1chr12132403929+ENST00000309909FBXW8chr12117461952+3929303517434641096
ENST00000321867ULK1chr12132403929+ENST00000455858FBXW8chr12117461952+6441303517434641096
ENST00000540647ULK1chr12132403929+ENST00000309909FBXW8chr12117461952+144755365982305
ENST00000540647ULK1chr12132403929+ENST00000455858FBXW8chr12117461952+395955365982305
ENST00000321867ULK1chr12132403929+ENST00000309909FBXW8chr12117461951+3929303517434641096
ENST00000321867ULK1chr12132403929+ENST00000455858FBXW8chr12117461951+6441303517434641096
ENST00000540647ULK1chr12132403929+ENST00000309909FBXW8chr12117461951+144755365982305
ENST00000540647ULK1chr12132403929+ENST00000455858FBXW8chr12117461951+395955365982305

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000321867ENST00000309909ULK1chr12132403929+FBXW8chr12117461952+0.0109887510.98901117
ENST00000321867ENST00000455858ULK1chr12132403929+FBXW8chr12117461952+0.0041421430.9958579
ENST00000540647ENST00000309909ULK1chr12132403929+FBXW8chr12117461952+0.111455040.8885449
ENST00000540647ENST00000455858ULK1chr12132403929+FBXW8chr12117461952+0.050796840.9492032
ENST00000321867ENST00000309909ULK1chr12132403929+FBXW8chr12117461951+0.0109887510.98901117
ENST00000321867ENST00000455858ULK1chr12132403929+FBXW8chr12117461951+0.0041421430.9958579
ENST00000540647ENST00000309909ULK1chr12132403929+FBXW8chr12117461951+0.111455040.8885449
ENST00000540647ENST00000455858ULK1chr12132403929+FBXW8chr12117461951+0.050796840.9492032

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>96750_96750_1_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000321867_FBXW8_chr12_117461951_ENST00000309909_length(amino acids)=1096AA_BP=946
MGPGPGLPDGARGPGDAPSPGPAPPAPRPRPARPGPRLRLSPPRLGPPPPAPRPRPACAMEPGRGGTETVGKFEFSRKDLIGHGAFAVVF
KGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ
IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSG
SSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVA
SAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPP
AHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLP
KPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTL
PDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSP
VVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEHT
EILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGG
EEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAM

--------------------------------------------------------------

>96750_96750_2_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000321867_FBXW8_chr12_117461951_ENST00000455858_length(amino acids)=1096AA_BP=946
MGPGPGLPDGARGPGDAPSPGPAPPAPRPRPARPGPRLRLSPPRLGPPPPAPRPRPACAMEPGRGGTETVGKFEFSRKDLIGHGAFAVVF
KGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ
IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSG
SSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVA
SAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPP
AHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLP
KPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTL
PDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSP
VVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEHT
EILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGG
EEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAM

--------------------------------------------------------------

>96750_96750_3_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000321867_FBXW8_chr12_117461952_ENST00000309909_length(amino acids)=1096AA_BP=946
MGPGPGLPDGARGPGDAPSPGPAPPAPRPRPARPGPRLRLSPPRLGPPPPAPRPRPACAMEPGRGGTETVGKFEFSRKDLIGHGAFAVVF
KGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ
IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSG
SSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVA
SAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPP
AHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLP
KPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTL
PDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSP
VVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEHT
EILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGG
EEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAM

--------------------------------------------------------------

>96750_96750_4_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000321867_FBXW8_chr12_117461952_ENST00000455858_length(amino acids)=1096AA_BP=946
MGPGPGLPDGARGPGDAPSPGPAPPAPRPRPARPGPRLRLSPPRLGPPPPAPRPRPACAMEPGRGGTETVGKFEFSRKDLIGHGAFAVVF
KGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ
IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSG
SSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVA
SAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPP
AHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLP
KPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTL
PDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSP
VVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEHT
EILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGG
EEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAM

--------------------------------------------------------------

>96750_96750_5_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000540647_FBXW8_chr12_117461951_ENST00000309909_length(amino acids)=305AA_BP=155
MGYNRCKPRQRHIGPWRCGSLWGMDGGHGVCWSWCAPHRPLPAAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGA
VTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSA
HQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAV

--------------------------------------------------------------

>96750_96750_6_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000540647_FBXW8_chr12_117461951_ENST00000455858_length(amino acids)=305AA_BP=155
MGYNRCKPRQRHIGPWRCGSLWGMDGGHGVCWSWCAPHRPLPAAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGA
VTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSA
HQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAV

--------------------------------------------------------------

>96750_96750_7_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000540647_FBXW8_chr12_117461952_ENST00000309909_length(amino acids)=305AA_BP=155
MGYNRCKPRQRHIGPWRCGSLWGMDGGHGVCWSWCAPHRPLPAAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGA
VTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSA
HQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAV

--------------------------------------------------------------

>96750_96750_8_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000540647_FBXW8_chr12_117461952_ENST00000455858_length(amino acids)=305AA_BP=155
MGYNRCKPRQRHIGPWRCGSLWGMDGGHGVCWSWCAPHRPLPAAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGA
VTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSA
HQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:132403929/chr12:117461952)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FBXW8

Q8N3Y1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). {ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneULK1chr12:132403929chr12:117461951ENST00000321867+2428297_310894.66666666666661051.0Compositional biasNote=Poly-Ser
HgeneULK1chr12:132403929chr12:117461952ENST00000321867+2428297_310894.66666666666661051.0Compositional biasNote=Poly-Ser
HgeneULK1chr12:132403929chr12:117461951ENST00000321867+242816_278894.66666666666661051.0DomainProtein kinase
HgeneULK1chr12:132403929chr12:117461952ENST00000321867+242816_278894.66666666666661051.0DomainProtein kinase
HgeneULK1chr12:132403929chr12:117461951ENST00000321867+242822_30894.66666666666661051.0Nucleotide bindingATP
HgeneULK1chr12:132403929chr12:117461952ENST00000321867+242822_30894.66666666666661051.0Nucleotide bindingATP
TgeneFBXW8chr12:132403929chr12:117461951ENST00000309909711473_510455.6666666666667599.0RepeatNote=WD 5
TgeneFBXW8chr12:132403929chr12:117461951ENST00000455858711430_470389.6666666666667533.0RepeatNote=WD 4
TgeneFBXW8chr12:132403929chr12:117461951ENST00000455858711473_510389.6666666666667533.0RepeatNote=WD 5
TgeneFBXW8chr12:132403929chr12:117461952ENST00000309909711473_510455.6666666666667599.0RepeatNote=WD 5
TgeneFBXW8chr12:132403929chr12:117461952ENST00000455858711430_470389.6666666666667533.0RepeatNote=WD 4
TgeneFBXW8chr12:132403929chr12:117461952ENST00000455858711473_510389.6666666666667533.0RepeatNote=WD 5

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFBXW8chr12:132403929chr12:117461951ENST00000309909711113_159455.6666666666667599.0DomainF-box
TgeneFBXW8chr12:132403929chr12:117461951ENST00000455858711113_159389.6666666666667533.0DomainF-box
TgeneFBXW8chr12:132403929chr12:117461952ENST00000309909711113_159455.6666666666667599.0DomainF-box
TgeneFBXW8chr12:132403929chr12:117461952ENST00000455858711113_159389.6666666666667533.0DomainF-box
TgeneFBXW8chr12:132403929chr12:117461951ENST00000309909711197_245455.6666666666667599.0RepeatNote=WD 1
TgeneFBXW8chr12:132403929chr12:117461951ENST00000309909711254_294455.6666666666667599.0RepeatNote=WD 2
TgeneFBXW8chr12:132403929chr12:117461951ENST00000309909711297_336455.6666666666667599.0RepeatNote=WD 3
TgeneFBXW8chr12:132403929chr12:117461951ENST00000309909711430_470455.6666666666667599.0RepeatNote=WD 4
TgeneFBXW8chr12:132403929chr12:117461951ENST00000455858711197_245389.6666666666667533.0RepeatNote=WD 1
TgeneFBXW8chr12:132403929chr12:117461951ENST00000455858711254_294389.6666666666667533.0RepeatNote=WD 2
TgeneFBXW8chr12:132403929chr12:117461951ENST00000455858711297_336389.6666666666667533.0RepeatNote=WD 3
TgeneFBXW8chr12:132403929chr12:117461952ENST00000309909711197_245455.6666666666667599.0RepeatNote=WD 1
TgeneFBXW8chr12:132403929chr12:117461952ENST00000309909711254_294455.6666666666667599.0RepeatNote=WD 2
TgeneFBXW8chr12:132403929chr12:117461952ENST00000309909711297_336455.6666666666667599.0RepeatNote=WD 3
TgeneFBXW8chr12:132403929chr12:117461952ENST00000309909711430_470455.6666666666667599.0RepeatNote=WD 4
TgeneFBXW8chr12:132403929chr12:117461952ENST00000455858711197_245389.6666666666667533.0RepeatNote=WD 1
TgeneFBXW8chr12:132403929chr12:117461952ENST00000455858711254_294389.6666666666667533.0RepeatNote=WD 2
TgeneFBXW8chr12:132403929chr12:117461952ENST00000455858711297_336389.6666666666667533.0RepeatNote=WD 3


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1862_ULK1_132403929_FBXW8_117461952_ranked_0.pdbULK1132403929132403929ENST00000455858FBXW8chr12117461952+
MGPGPGLPDGARGPGDAPSPGPAPPAPRPRPARPGPRLRLSPPRLGPPPPAPRPRPACAMEPGRGGTETVGKFEFSRKDLIGHGAFAVVF
KGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ
IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSG
SSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVA
SAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPP
AHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLP
KPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTL
PDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSP
VVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEHT
EILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGG
EEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAM
1096


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ULK1_pLDDT.png
all structure
all structure
FBXW8_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ULK1
FBXW8


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ULK1-FBXW8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ULK1-FBXW8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource