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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:UNC13B-PTPRD

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: UNC13B-PTPRD
FusionPDB ID: 96808
FusionGDB2.0 ID: 96808
HgeneTgene
Gene symbol

UNC13B

PTPRD

Gene ID

10497

5789

Gene nameunc-13 homolog Bprotein tyrosine phosphatase receptor type D
SynonymsMUNC13|UNC13|Unc13h2|munc13-2HPTP|HPTPD|HPTPDELTA|PTPD|R-PTP-delta|RPTPDELTA
Cytomap

9p13.3

9p24.1-p23

Type of geneprotein-codingprotein-coding
Descriptionprotein unc-13 homolog Bhomolog of rat Munc13 (diacylglycerol-binding)unc-13-likereceptor-type tyrosine-protein phosphatase deltaprotein tyrosine phosphatase, receptor type, delta polypeptiderceptor-type tyrosine-protein phosphatase delta
Modification date2020032920200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000378495, ENST00000378496, 
ENST00000396787, ENST00000481299, 
ENST00000471274, ENST00000355233, 
ENST00000356435, ENST00000358503, 
ENST00000360074, ENST00000381196, 
ENST00000397606, ENST00000397611, 
ENST00000397617, ENST00000463477, 
ENST00000486161, ENST00000537002, 
ENST00000540109, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 8 X 6=52827 X 25 X 10=6750
# samples 1128
** MAII scorelog2(11/528*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/6750*10)=-4.59138876988059
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: UNC13B [Title/Abstract] AND PTPRD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)UNC13B(35386290)-PTPRD(8636844), # samples:2
Anticipated loss of major functional domain due to fusion event.UNC13B-PTPRD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UNC13B-PTPRD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UNC13B-PTPRD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UNC13B-PTPRD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UNC13B-PTPRD seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
UNC13B-PTPRD seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
UNC13B-PTPRD seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUNC13B

GO:0043065

positive regulation of apoptotic process

10233166

HgeneUNC13B

GO:0050714

positive regulation of protein secretion

19641095

HgeneUNC13B

GO:0060478

acrosomal vesicle exocytosis

22248876

HgeneUNC13B

GO:0071333

cellular response to glucose stimulus

19641095

TgenePTPRD

GO:0099545

trans-synaptic signaling by trans-synaptic complex

21926414

TgenePTPRD

GO:0099560

synaptic membrane adhesion

23345436

TgenePTPRD

GO:1905606

regulation of presynapse assembly

21926414


check buttonFusion gene breakpoints across UNC13B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTPRD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CF-A27C-01AUNC13Bchr9

35386290

-PTPRDchr9

8636844

-
ChimerDB4BLCATCGA-CF-A27C-01AUNC13Bchr9

35386290

+PTPRDchr9

8636844

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396787UNC13Bchr935386290+ENST00000540109PTPRDchr98636844-92053165313188391902
ENST00000378495UNC13Bchr935386290+ENST00000540109PTPRDchr98636844-91093069303587431902
ENST00000378496UNC13Bchr935386290+ENST00000540109PTPRDchr98636844-90673027299387011902

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396787ENST00000540109UNC13Bchr935386290+PTPRDchr98636844-0.015806020.984194
ENST00000378495ENST00000540109UNC13Bchr935386290+PTPRDchr98636844-0.014850040.98515
ENST00000378496ENST00000540109UNC13Bchr935386290+PTPRDchr98636844-0.01457890.9854211

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>96808_96808_1_UNC13B-PTPRD_UNC13B_chr9_35386290_ENST00000378495_PTPRD_chr9_8636844_ENST00000540109_length(amino acids)=1902AA_BP=11
MPRLIQPPVPAAPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVA
SNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRG
ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPED
DMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEI
DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPT
QHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELV
YKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNG
IITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKV
SWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT
GAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKE
ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSK
GPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGN
SAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSI
RYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWV
VGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE
YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSAT
VVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT
CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQ
KLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP
LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPE
QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA

--------------------------------------------------------------

>96808_96808_2_UNC13B-PTPRD_UNC13B_chr9_35386290_ENST00000378496_PTPRD_chr9_8636844_ENST00000540109_length(amino acids)=1902AA_BP=11
MPRLIQPPVPAAPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVA
SNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRG
ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPED
DMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEI
DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPT
QHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELV
YKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNG
IITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKV
SWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT
GAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKE
ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSK
GPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGN
SAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSI
RYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWV
VGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE
YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSAT
VVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT
CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQ
KLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP
LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPE
QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA

--------------------------------------------------------------

>96808_96808_3_UNC13B-PTPRD_UNC13B_chr9_35386290_ENST00000396787_PTPRD_chr9_8636844_ENST00000540109_length(amino acids)=1902AA_BP=11
MPRLIQPPVPAAPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVA
SNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRG
ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPED
DMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEI
DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPT
QHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELV
YKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNG
IITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKV
SWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT
GAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKE
ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSK
GPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGN
SAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSI
RYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWV
VGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE
YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSAT
VVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT
CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQ
KLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP
LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPE
QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:35386290/chr9:8636844)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUNC13Bchr9:35386290chr9:8636844ENST00000378495+2339583_707949.01592.0DomainC2 2
HgeneUNC13Bchr9:35386290chr9:8636844ENST00000378495+2339477_527949.01592.0Zinc fingerPhorbol-ester/DAG-type
TgenePTPRDchr9:35386290chr9:8636844ENST000003552330311020_110621.3333333333333321507.0DomainFibronectin type-III 8
TgenePTPRDchr9:35386290chr9:8636844ENST00000355233031126_22421.3333333333333321507.0DomainNote=Ig-like C2-type 2
TgenePTPRDchr9:35386290chr9:8636844ENST000003552330311357_161221.3333333333333321507.0DomainTyrosine-protein phosphatase 1
TgenePTPRDchr9:35386290chr9:8636844ENST000003552330311644_190321.3333333333333321507.0DomainTyrosine-protein phosphatase 2
TgenePTPRDchr9:35386290chr9:8636844ENST00000355233031236_31821.3333333333333321507.0DomainNote=Ig-like C2-type 3
TgenePTPRDchr9:35386290chr9:8636844ENST0000035523303124_11421.3333333333333321507.0DomainNote=Ig-like C2-type 1
TgenePTPRDchr9:35386290chr9:8636844ENST00000355233031325_41521.3333333333333321507.0DomainFibronectin type-III 1
TgenePTPRDchr9:35386290chr9:8636844ENST00000355233031420_51621.3333333333333321507.0DomainFibronectin type-III 2
TgenePTPRDchr9:35386290chr9:8636844ENST00000355233031518_60721.3333333333333321507.0DomainFibronectin type-III 3
TgenePTPRDchr9:35386290chr9:8636844ENST00000355233031612_70921.3333333333333321507.0DomainFibronectin type-III 4
TgenePTPRDchr9:35386290chr9:8636844ENST00000355233031714_82221.3333333333333321507.0DomainFibronectin type-III 5
TgenePTPRDchr9:35386290chr9:8636844ENST00000355233031823_91621.3333333333333321507.0DomainFibronectin type-III 6
TgenePTPRDchr9:35386290chr9:8636844ENST00000355233031921_101621.3333333333333321507.0DomainFibronectin type-III 7
TgenePTPRDchr9:35386290chr9:8636844ENST000003564350351020_110621.3333333333333321913.0DomainFibronectin type-III 8
TgenePTPRDchr9:35386290chr9:8636844ENST00000356435035126_22421.3333333333333321913.0DomainNote=Ig-like C2-type 2
TgenePTPRDchr9:35386290chr9:8636844ENST000003564350351357_161221.3333333333333321913.0DomainTyrosine-protein phosphatase 1
TgenePTPRDchr9:35386290chr9:8636844ENST000003564350351644_190321.3333333333333321913.0DomainTyrosine-protein phosphatase 2
TgenePTPRDchr9:35386290chr9:8636844ENST00000356435035236_31821.3333333333333321913.0DomainNote=Ig-like C2-type 3
TgenePTPRDchr9:35386290chr9:8636844ENST0000035643503524_11421.3333333333333321913.0DomainNote=Ig-like C2-type 1
TgenePTPRDchr9:35386290chr9:8636844ENST00000356435035325_41521.3333333333333321913.0DomainFibronectin type-III 1
TgenePTPRDchr9:35386290chr9:8636844ENST00000356435035420_51621.3333333333333321913.0DomainFibronectin type-III 2
TgenePTPRDchr9:35386290chr9:8636844ENST00000356435035518_60721.3333333333333321913.0DomainFibronectin type-III 3
TgenePTPRDchr9:35386290chr9:8636844ENST00000356435035612_70921.3333333333333321913.0DomainFibronectin type-III 4
TgenePTPRDchr9:35386290chr9:8636844ENST00000356435035714_82221.3333333333333321913.0DomainFibronectin type-III 5
TgenePTPRDchr9:35386290chr9:8636844ENST00000356435035823_91621.3333333333333321913.0DomainFibronectin type-III 6
TgenePTPRDchr9:35386290chr9:8636844ENST00000356435035921_101621.3333333333333321913.0DomainFibronectin type-III 7
TgenePTPRDchr9:35386290chr9:8636844ENST000003811968431020_110621.3333333333333321913.0DomainFibronectin type-III 8
TgenePTPRDchr9:35386290chr9:8636844ENST00000381196843126_22421.3333333333333321913.0DomainNote=Ig-like C2-type 2
TgenePTPRDchr9:35386290chr9:8636844ENST000003811968431357_161221.3333333333333321913.0DomainTyrosine-protein phosphatase 1
TgenePTPRDchr9:35386290chr9:8636844ENST000003811968431644_190321.3333333333333321913.0DomainTyrosine-protein phosphatase 2
TgenePTPRDchr9:35386290chr9:8636844ENST00000381196843236_31821.3333333333333321913.0DomainNote=Ig-like C2-type 3
TgenePTPRDchr9:35386290chr9:8636844ENST0000038119684324_11421.3333333333333321913.0DomainNote=Ig-like C2-type 1
TgenePTPRDchr9:35386290chr9:8636844ENST00000381196843325_41521.3333333333333321913.0DomainFibronectin type-III 1
TgenePTPRDchr9:35386290chr9:8636844ENST00000381196843420_51621.3333333333333321913.0DomainFibronectin type-III 2
TgenePTPRDchr9:35386290chr9:8636844ENST00000381196843518_60721.3333333333333321913.0DomainFibronectin type-III 3
TgenePTPRDchr9:35386290chr9:8636844ENST00000381196843612_70921.3333333333333321913.0DomainFibronectin type-III 4
TgenePTPRDchr9:35386290chr9:8636844ENST00000381196843714_82221.3333333333333321913.0DomainFibronectin type-III 5
TgenePTPRDchr9:35386290chr9:8636844ENST00000381196843823_91621.3333333333333321913.0DomainFibronectin type-III 6
TgenePTPRDchr9:35386290chr9:8636844ENST00000381196843921_101621.3333333333333321913.0DomainFibronectin type-III 7
TgenePTPRDchr9:35386290chr9:8636844ENST000003976060291020_110621.3333333333333321506.0DomainFibronectin type-III 8
TgenePTPRDchr9:35386290chr9:8636844ENST00000397606029126_22421.3333333333333321506.0DomainNote=Ig-like C2-type 2
TgenePTPRDchr9:35386290chr9:8636844ENST000003976060291357_161221.3333333333333321506.0DomainTyrosine-protein phosphatase 1
TgenePTPRDchr9:35386290chr9:8636844ENST000003976060291644_190321.3333333333333321506.0DomainTyrosine-protein phosphatase 2
TgenePTPRDchr9:35386290chr9:8636844ENST00000397606029236_31821.3333333333333321506.0DomainNote=Ig-like C2-type 3
TgenePTPRDchr9:35386290chr9:8636844ENST0000039760602924_11421.3333333333333321506.0DomainNote=Ig-like C2-type 1
TgenePTPRDchr9:35386290chr9:8636844ENST00000397606029325_41521.3333333333333321506.0DomainFibronectin type-III 1
TgenePTPRDchr9:35386290chr9:8636844ENST00000397606029420_51621.3333333333333321506.0DomainFibronectin type-III 2
TgenePTPRDchr9:35386290chr9:8636844ENST00000397606029518_60721.3333333333333321506.0DomainFibronectin type-III 3
TgenePTPRDchr9:35386290chr9:8636844ENST00000397606029612_70921.3333333333333321506.0DomainFibronectin type-III 4
TgenePTPRDchr9:35386290chr9:8636844ENST00000397606029714_82221.3333333333333321506.0DomainFibronectin type-III 5
TgenePTPRDchr9:35386290chr9:8636844ENST00000397606029823_91621.3333333333333321506.0DomainFibronectin type-III 6
TgenePTPRDchr9:35386290chr9:8636844ENST00000397606029921_101621.3333333333333321506.0DomainFibronectin type-III 7
TgenePTPRDchr9:35386290chr9:8636844ENST000004861610311020_110621.3333333333333321506.0DomainFibronectin type-III 8
TgenePTPRDchr9:35386290chr9:8636844ENST00000486161031126_22421.3333333333333321506.0DomainNote=Ig-like C2-type 2
TgenePTPRDchr9:35386290chr9:8636844ENST000004861610311357_161221.3333333333333321506.0DomainTyrosine-protein phosphatase 1
TgenePTPRDchr9:35386290chr9:8636844ENST000004861610311644_190321.3333333333333321506.0DomainTyrosine-protein phosphatase 2
TgenePTPRDchr9:35386290chr9:8636844ENST00000486161031236_31821.3333333333333321506.0DomainNote=Ig-like C2-type 3
TgenePTPRDchr9:35386290chr9:8636844ENST0000048616103124_11421.3333333333333321506.0DomainNote=Ig-like C2-type 1
TgenePTPRDchr9:35386290chr9:8636844ENST00000486161031325_41521.3333333333333321506.0DomainFibronectin type-III 1
TgenePTPRDchr9:35386290chr9:8636844ENST00000486161031420_51621.3333333333333321506.0DomainFibronectin type-III 2
TgenePTPRDchr9:35386290chr9:8636844ENST00000486161031518_60721.3333333333333321506.0DomainFibronectin type-III 3
TgenePTPRDchr9:35386290chr9:8636844ENST00000486161031612_70921.3333333333333321506.0DomainFibronectin type-III 4
TgenePTPRDchr9:35386290chr9:8636844ENST00000486161031714_82221.3333333333333321506.0DomainFibronectin type-III 5
TgenePTPRDchr9:35386290chr9:8636844ENST00000486161031823_91621.3333333333333321506.0DomainFibronectin type-III 6
TgenePTPRDchr9:35386290chr9:8636844ENST00000486161031921_101621.3333333333333321506.0DomainFibronectin type-III 7
TgenePTPRDchr9:35386290chr9:8636844ENST000005401090361020_110621.3333333333333321952.3333333333333DomainFibronectin type-III 8
TgenePTPRDchr9:35386290chr9:8636844ENST00000540109036126_22421.3333333333333321952.3333333333333DomainNote=Ig-like C2-type 2
TgenePTPRDchr9:35386290chr9:8636844ENST000005401090361357_161221.3333333333333321952.3333333333333DomainTyrosine-protein phosphatase 1
TgenePTPRDchr9:35386290chr9:8636844ENST000005401090361644_190321.3333333333333321952.3333333333333DomainTyrosine-protein phosphatase 2
TgenePTPRDchr9:35386290chr9:8636844ENST00000540109036236_31821.3333333333333321952.3333333333333DomainNote=Ig-like C2-type 3
TgenePTPRDchr9:35386290chr9:8636844ENST0000054010903624_11421.3333333333333321952.3333333333333DomainNote=Ig-like C2-type 1
TgenePTPRDchr9:35386290chr9:8636844ENST00000540109036325_41521.3333333333333321952.3333333333333DomainFibronectin type-III 1
TgenePTPRDchr9:35386290chr9:8636844ENST00000540109036420_51621.3333333333333321952.3333333333333DomainFibronectin type-III 2
TgenePTPRDchr9:35386290chr9:8636844ENST00000540109036518_60721.3333333333333321952.3333333333333DomainFibronectin type-III 3
TgenePTPRDchr9:35386290chr9:8636844ENST00000540109036612_70921.3333333333333321952.3333333333333DomainFibronectin type-III 4
TgenePTPRDchr9:35386290chr9:8636844ENST00000540109036714_82221.3333333333333321952.3333333333333DomainFibronectin type-III 5
TgenePTPRDchr9:35386290chr9:8636844ENST00000540109036823_91621.3333333333333321952.3333333333333DomainFibronectin type-III 6
TgenePTPRDchr9:35386290chr9:8636844ENST00000540109036921_101621.3333333333333321952.3333333333333DomainFibronectin type-III 7
TgenePTPRDchr9:35386290chr9:8636844ENST000003552330311553_155921.3333333333333321507.0RegionSubstrate binding
TgenePTPRDchr9:35386290chr9:8636844ENST000003564350351553_155921.3333333333333321913.0RegionSubstrate binding
TgenePTPRDchr9:35386290chr9:8636844ENST000003811968431553_155921.3333333333333321913.0RegionSubstrate binding
TgenePTPRDchr9:35386290chr9:8636844ENST000003976060291553_155921.3333333333333321506.0RegionSubstrate binding
TgenePTPRDchr9:35386290chr9:8636844ENST000004861610311553_155921.3333333333333321506.0RegionSubstrate binding
TgenePTPRDchr9:35386290chr9:8636844ENST000005401090361553_155921.3333333333333321952.3333333333333RegionSubstrate binding
TgenePTPRDchr9:35386290chr9:8636844ENST000003552330311291_191221.3333333333333321507.0Topological domainCytoplasmic
TgenePTPRDchr9:35386290chr9:8636844ENST0000035523303121_126521.3333333333333321507.0Topological domainExtracellular
TgenePTPRDchr9:35386290chr9:8636844ENST000003564350351291_191221.3333333333333321913.0Topological domainCytoplasmic
TgenePTPRDchr9:35386290chr9:8636844ENST0000035643503521_126521.3333333333333321913.0Topological domainExtracellular
TgenePTPRDchr9:35386290chr9:8636844ENST000003811968431291_191221.3333333333333321913.0Topological domainCytoplasmic
TgenePTPRDchr9:35386290chr9:8636844ENST0000038119684321_126521.3333333333333321913.0Topological domainExtracellular
TgenePTPRDchr9:35386290chr9:8636844ENST000003976060291291_191221.3333333333333321506.0Topological domainCytoplasmic
TgenePTPRDchr9:35386290chr9:8636844ENST0000039760602921_126521.3333333333333321506.0Topological domainExtracellular
TgenePTPRDchr9:35386290chr9:8636844ENST000004861610311291_191221.3333333333333321506.0Topological domainCytoplasmic
TgenePTPRDchr9:35386290chr9:8636844ENST0000048616103121_126521.3333333333333321506.0Topological domainExtracellular
TgenePTPRDchr9:35386290chr9:8636844ENST000005401090361291_191221.3333333333333321952.3333333333333Topological domainCytoplasmic
TgenePTPRDchr9:35386290chr9:8636844ENST0000054010903621_126521.3333333333333321952.3333333333333Topological domainExtracellular
TgenePTPRDchr9:35386290chr9:8636844ENST000003552330311266_129021.3333333333333321507.0TransmembraneHelical
TgenePTPRDchr9:35386290chr9:8636844ENST000003564350351266_129021.3333333333333321913.0TransmembraneHelical
TgenePTPRDchr9:35386290chr9:8636844ENST000003811968431266_129021.3333333333333321913.0TransmembraneHelical
TgenePTPRDchr9:35386290chr9:8636844ENST000003976060291266_129021.3333333333333321506.0TransmembraneHelical
TgenePTPRDchr9:35386290chr9:8636844ENST000004861610311266_129021.3333333333333321506.0TransmembraneHelical
TgenePTPRDchr9:35386290chr9:8636844ENST000005401090361266_129021.3333333333333321952.3333333333333TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUNC13Bchr9:35386290chr9:8636844ENST00000378495+23391172_1202949.01592.0Coiled coilOntology_term=ECO:0000255
HgeneUNC13Bchr9:35386290chr9:8636844ENST00000378495+23391013_1156949.01592.0DomainMHD1
HgeneUNC13Bchr9:35386290chr9:8636844ENST00000378495+23391263_1405949.01592.0DomainMHD2
HgeneUNC13Bchr9:35386290chr9:8636844ENST00000378495+23391419_1546949.01592.0DomainC2 3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
UNC13B
PTPRD


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to UNC13B-PTPRD


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to UNC13B-PTPRD


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource