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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:UNC45A-BLM

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: UNC45A-BLM
FusionPDB ID: 96824
FusionGDB2.0 ID: 96824
HgeneTgene
Gene symbol

UNC45A

BLM

Gene ID

55898

641

Gene nameunc-45 myosin chaperone ABLM RecQ like helicase
SynonymsGC-UNC45|GCUNC-45|GCUNC45|IRO039700|SMAP-1|SMAP1|UNC-45ABS|MGRISCE1|RECQ2|RECQL2|RECQL3
Cytomap

15q26.1

15q26.1

Type of geneprotein-codingprotein-coding
Descriptionprotein unc-45 homolog Ageneral cell UNC45smooth muscle cell associated protein-1unc-45 homolog ABloom syndrome proteinBloom syndrome RecQ like helicaseBloom syndrome, RecQ helicase-likeDNA helicase, RecQ-like type 2recQ protein-like 3
Modification date2020031320200313
UniProtAcc.

Q13867

Ensembl transtripts involved in fusion geneENST idsENST00000553671, ENST00000394275, 
ENST00000418476, 		ENST00000355112, 
ENST00000560509, ENST00000560136, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 3 X 6=1087 X 13 X 3=273
# samples 98
** MAII scorelog2(9/108*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/273*10)=-1.77082904603249
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: UNC45A [Title/Abstract] AND BLM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)UNC45A(91493845)-BLM(91298041), # samples:2
UNC45A(91483703)-BLM(91358332), # samples:2
Anticipated loss of major functional domain due to fusion event.UNC45A-BLM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UNC45A-BLM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UNC45A-BLM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UNC45A-BLM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBLM

GO:0000729

DNA double-strand break processing

21325134

TgeneBLM

GO:0006974

cellular response to DNA damage stimulus

23509288

TgeneBLM

GO:0007095

mitotic G2 DNA damage checkpoint

11309417

TgeneBLM

GO:0010165

response to X-ray

11309417

TgeneBLM

GO:0031297

replication fork processing

17115688

TgeneBLM

GO:0032508

DNA duplex unwinding

11735402|24816114|25901030

TgeneBLM

GO:0044806

G-quadruplex DNA unwinding

11735402

TgeneBLM

GO:0045893

positive regulation of transcription, DNA-templated

11781842

TgeneBLM

GO:0051259

protein complex oligomerization

28228481

TgeneBLM

GO:0051260

protein homooligomerization

28228481

TgeneBLM

GO:0061820

telomeric D-loop disassembly

19734539

TgeneBLM

GO:0071479

cellular response to ionizing radiation

23509288

TgeneBLM

GO:0072711

cellular response to hydroxyurea

23509288

TgeneBLM

GO:0072757

cellular response to camptothecin

23509288


check buttonFusion gene breakpoints across UNC45A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BLM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-38-4630-01AUNC45Achr15

91493845

+BLMchr15

91298041

+
ChimerDB4LUADTCGA-38-4630UNC45Achr15

91493845

+BLMchr15

91298040

+
ChimerDB4LUADTCGA-49-AAQV-01AUNC45Achr15

91483703

-BLMchr15

91358332

+
ChimerDB4LUADTCGA-49-AAQV-01AUNC45Achr15

91483703

+BLMchr15

91358332

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394275UNC45Achr1591493845+ENST00000355112BLMchr1591298041+6571309375763871876
ENST00000394275UNC45Achr1591493845+ENST00000560509BLMchr1591298041+6049309375759941745
ENST00000418476UNC45Achr1591493845+ENST00000355112BLMchr1591298041+582123434056371865
ENST00000418476UNC45Achr1591493845+ENST00000560509BLMchr1591298041+529923434052441734
ENST00000394275UNC45Achr1591483703+ENST00000355112BLMchr1591358332+183814777571494245
ENST00000394275UNC45Achr1591483703+ENST00000560509BLMchr1591358332+170914777571494245
ENST00000418476UNC45Achr1591483703+ENST00000355112BLMchr1591358332+108872740744234
ENST00000418476UNC45Achr1591483703+ENST00000560509BLMchr1591358332+95972740744234
ENST00000394275UNC45Achr1591493845+ENST00000355112BLMchr1591298040+6571309375763871876
ENST00000394275UNC45Achr1591493845+ENST00000560509BLMchr1591298040+6049309375759941745
ENST00000418476UNC45Achr1591493845+ENST00000355112BLMchr1591298040+582123434056371865
ENST00000418476UNC45Achr1591493845+ENST00000560509BLMchr1591298040+529923434052441734

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394275ENST00000355112UNC45Achr1591493845+BLMchr1591298041+0.0010110520.9989889
ENST00000394275ENST00000560509UNC45Achr1591493845+BLMchr1591298041+0.0023870.99761295
ENST00000418476ENST00000355112UNC45Achr1591493845+BLMchr1591298041+0.0003865440.99961346
ENST00000418476ENST00000560509UNC45Achr1591493845+BLMchr1591298041+0.0010131020.9989869
ENST00000394275ENST00000355112UNC45Achr1591483703+BLMchr1591358332+0.0044193520.9955806
ENST00000394275ENST00000560509UNC45Achr1591483703+BLMchr1591358332+0.00437960.9956204
ENST00000418476ENST00000355112UNC45Achr1591483703+BLMchr1591358332+0.0026356710.99736434
ENST00000418476ENST00000560509UNC45Achr1591483703+BLMchr1591358332+0.0028414450.9971585
ENST00000394275ENST00000355112UNC45Achr1591493845+BLMchr1591298040+0.0010110520.9989889
ENST00000394275ENST00000560509UNC45Achr1591493845+BLMchr1591298040+0.0023870.99761295
ENST00000418476ENST00000355112UNC45Achr1591493845+BLMchr1591298040+0.0003865440.99961346
ENST00000418476ENST00000560509UNC45Achr1591493845+BLMchr1591298040+0.0010131020.9989869

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>96824_96824_1_UNC45A-BLM_UNC45A_chr15_91483703_ENST00000394275_BLM_chr15_91358332_ENST00000355112_length(amino acids)=245AA_BP=
MPVASRTQTRPAPETAPARARDNLSAMTASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAET
EASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTE

--------------------------------------------------------------

>96824_96824_2_UNC45A-BLM_UNC45A_chr15_91483703_ENST00000394275_BLM_chr15_91358332_ENST00000560509_length(amino acids)=245AA_BP=
MPVASRTQTRPAPETAPARARDNLSAMTASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAET
EASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTE

--------------------------------------------------------------

>96824_96824_3_UNC45A-BLM_UNC45A_chr15_91483703_ENST00000418476_BLM_chr15_91358332_ENST00000355112_length(amino acids)=234AA_BP=
MTVSGPGTPEPRPATPGASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKAIEKDGG
DVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVV

--------------------------------------------------------------

>96824_96824_4_UNC45A-BLM_UNC45A_chr15_91483703_ENST00000418476_BLM_chr15_91358332_ENST00000560509_length(amino acids)=234AA_BP=
MTVSGPGTPEPRPATPGASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKAIEKDGG
DVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVV

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>96824_96824_5_UNC45A-BLM_UNC45A_chr15_91493845_ENST00000394275_BLM_chr15_91298040_ENST00000355112_length(amino acids)=1876AA_BP=779
MPVASRTQTRPAPETAPARARDNLSAMTASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAET
EASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTE
KKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDMGETDLMLAALRTLVGICSEHQSRTVATLSILGTRRVVSILGVESQAVSLAACH
LLQVMFDALKEGVKKGFRGKEGAIIVDPARELKVLISNLLDLLTEVGVSGQGRDNALTLLIKAVPRKSLKDPNNSLTLWVIDQGLKKILE
VGGSLQDPPGELAVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVM
ESVIALCASEQEEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKCSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQ
CRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSRLEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQH
VPEQHPKDKPSFVRARVKKLLAAGVVSAMVCMVKTESPVLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGRALIPLALEGTDVGQTKAA
QALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQ
ELNPETSTDCDARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEG
DSCPTGNSMKELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVK
DQNKHTASINDLERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSE
SIQNYTDKSAQNLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTV
VISPLRSLIVDQVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVS
QWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSG
IIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAG
RDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKD
YKTRDVTDDVKSIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLGSKSAKIQSGIFGKGSAYSRHNAERLFKKLILDKILDEDLYI
NANDQAIAYVMLGNKAQTVLNGNLKVDFMETENSSSVKKQKALVAKVSQREEMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAE
SLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSSSRGPGRSAAEELDEEIPVSSHYFASKTRNERKRKKMPA

--------------------------------------------------------------

>96824_96824_6_UNC45A-BLM_UNC45A_chr15_91493845_ENST00000394275_BLM_chr15_91298040_ENST00000560509_length(amino acids)=1745AA_BP=779
MPVASRTQTRPAPETAPARARDNLSAMTASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAET
EASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTE
KKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDMGETDLMLAALRTLVGICSEHQSRTVATLSILGTRRVVSILGVESQAVSLAACH
LLQVMFDALKEGVKKGFRGKEGAIIVDPARELKVLISNLLDLLTEVGVSGQGRDNALTLLIKAVPRKSLKDPNNSLTLWVIDQGLKKILE
VGGSLQDPPGELAVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVM
ESVIALCASEQEEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKCSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQ
CRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSRLEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQH
VPEQHPKDKPSFVRARVKKLLAAGVVSAMVCMVKTESPVLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGRALIPLALEGTDVGQTKAA
QALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQ
ELNPETSTDCDARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEG
DSCPTGNSMKELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVK
DQNKHTASINDLERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSE
SIQNYTDKSAQNLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTV
VISPLRSLIVDQVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVS
QWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSG
IIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAG
RDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKD
YKTRDVTDDVKSIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPA
EDSSPGISLSSSRGPGRSAAEELDEEIPVSSHYFASKTRNERKRKKMPASQRSKRRKTASSGSKAKGGSATCRKISSKTKSSSIIGSSSA

--------------------------------------------------------------

>96824_96824_7_UNC45A-BLM_UNC45A_chr15_91493845_ENST00000394275_BLM_chr15_91298041_ENST00000355112_length(amino acids)=1876AA_BP=779
MPVASRTQTRPAPETAPARARDNLSAMTASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAET
EASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTE
KKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDMGETDLMLAALRTLVGICSEHQSRTVATLSILGTRRVVSILGVESQAVSLAACH
LLQVMFDALKEGVKKGFRGKEGAIIVDPARELKVLISNLLDLLTEVGVSGQGRDNALTLLIKAVPRKSLKDPNNSLTLWVIDQGLKKILE
VGGSLQDPPGELAVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVM
ESVIALCASEQEEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKCSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQ
CRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSRLEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQH
VPEQHPKDKPSFVRARVKKLLAAGVVSAMVCMVKTESPVLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGRALIPLALEGTDVGQTKAA
QALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQ
ELNPETSTDCDARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEG
DSCPTGNSMKELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVK
DQNKHTASINDLERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSE
SIQNYTDKSAQNLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTV
VISPLRSLIVDQVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVS
QWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSG
IIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAG
RDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKD
YKTRDVTDDVKSIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLGSKSAKIQSGIFGKGSAYSRHNAERLFKKLILDKILDEDLYI
NANDQAIAYVMLGNKAQTVLNGNLKVDFMETENSSSVKKQKALVAKVSQREEMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAE
SLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSSSRGPGRSAAEELDEEIPVSSHYFASKTRNERKRKKMPA

--------------------------------------------------------------

>96824_96824_8_UNC45A-BLM_UNC45A_chr15_91493845_ENST00000394275_BLM_chr15_91298041_ENST00000560509_length(amino acids)=1745AA_BP=779
MPVASRTQTRPAPETAPARARDNLSAMTASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAET
EASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTE
KKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDMGETDLMLAALRTLVGICSEHQSRTVATLSILGTRRVVSILGVESQAVSLAACH
LLQVMFDALKEGVKKGFRGKEGAIIVDPARELKVLISNLLDLLTEVGVSGQGRDNALTLLIKAVPRKSLKDPNNSLTLWVIDQGLKKILE
VGGSLQDPPGELAVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVM
ESVIALCASEQEEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKCSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQ
CRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSRLEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQH
VPEQHPKDKPSFVRARVKKLLAAGVVSAMVCMVKTESPVLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGRALIPLALEGTDVGQTKAA
QALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQ
ELNPETSTDCDARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEG
DSCPTGNSMKELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVK
DQNKHTASINDLERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSE
SIQNYTDKSAQNLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTV
VISPLRSLIVDQVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVS
QWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSG
IIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAG
RDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKD
YKTRDVTDDVKSIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPA
EDSSPGISLSSSRGPGRSAAEELDEEIPVSSHYFASKTRNERKRKKMPASQRSKRRKTASSGSKAKGGSATCRKISSKTKSSSIIGSSSA

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>96824_96824_9_UNC45A-BLM_UNC45A_chr15_91493845_ENST00000418476_BLM_chr15_91298040_ENST00000355112_length(amino acids)=1865AA_BP=768
MTVSGPGTPEPRPATPGASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKAIEKDGG
DVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVV
LAREDAGAEKIFRSNGVQLLQRLLDMGETDLMLAALRTLVGICSEHQSRTVATLSILGTRRVVSILGVESQAVSLAACHLLQVMFDALKE
GVKKGFRGKEGAIIVDPARELKVLISNLLDLLTEVGVSGQGRDNALTLLIKAVPRKSLKDPNNSLTLWVIDQGLKKILEVGGSLQDPPGE
LAVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEQ
EEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKCSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQID
AGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSRLEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPS
FVRARVKKLLAAGVVSAMVCMVKTESPVLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGRALIPLALEGTDVGQTKAAQALAKLTITSN
PEMTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQELNPETSTDCD
ARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEGDSCPTGNSMKE
LNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASIND
LERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSESIQNYTDKSAQ
NLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVD
QVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYK
RMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECD
TMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLF
YTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKDYKTRDVTDDVK
SIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLGSKSAKIQSGIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQAIAYVM
LGNKAQTVLNGNLKVDFMETENSSSVKKQKALVAKVSQREEMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQ
IDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSSSRGPGRSAAEELDEEIPVSSHYFASKTRNERKRKKMPASQRSKRRKTAS

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>96824_96824_10_UNC45A-BLM_UNC45A_chr15_91493845_ENST00000418476_BLM_chr15_91298040_ENST00000560509_length(amino acids)=1734AA_BP=768
MTVSGPGTPEPRPATPGASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKAIEKDGG
DVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVV
LAREDAGAEKIFRSNGVQLLQRLLDMGETDLMLAALRTLVGICSEHQSRTVATLSILGTRRVVSILGVESQAVSLAACHLLQVMFDALKE
GVKKGFRGKEGAIIVDPARELKVLISNLLDLLTEVGVSGQGRDNALTLLIKAVPRKSLKDPNNSLTLWVIDQGLKKILEVGGSLQDPPGE
LAVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEQ
EEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKCSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQID
AGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSRLEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPS
FVRARVKKLLAAGVVSAMVCMVKTESPVLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGRALIPLALEGTDVGQTKAAQALAKLTITSN
PEMTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQELNPETSTDCD
ARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEGDSCPTGNSMKE
LNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASIND
LERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSESIQNYTDKSAQ
NLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVD
QVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYK
RMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECD
TMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLF
YTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKDYKTRDVTDDVK
SIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSS
SRGPGRSAAEELDEEIPVSSHYFASKTRNERKRKKMPASQRSKRRKTASSGSKAKGGSATCRKISSKTKSSSIIGSSSASHTSQATSGAN

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>96824_96824_11_UNC45A-BLM_UNC45A_chr15_91493845_ENST00000418476_BLM_chr15_91298041_ENST00000355112_length(amino acids)=1865AA_BP=768
MTVSGPGTPEPRPATPGASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKAIEKDGG
DVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVV
LAREDAGAEKIFRSNGVQLLQRLLDMGETDLMLAALRTLVGICSEHQSRTVATLSILGTRRVVSILGVESQAVSLAACHLLQVMFDALKE
GVKKGFRGKEGAIIVDPARELKVLISNLLDLLTEVGVSGQGRDNALTLLIKAVPRKSLKDPNNSLTLWVIDQGLKKILEVGGSLQDPPGE
LAVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEQ
EEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKCSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQID
AGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSRLEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPS
FVRARVKKLLAAGVVSAMVCMVKTESPVLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGRALIPLALEGTDVGQTKAAQALAKLTITSN
PEMTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQELNPETSTDCD
ARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEGDSCPTGNSMKE
LNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASIND
LERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSESIQNYTDKSAQ
NLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVD
QVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYK
RMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECD
TMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLF
YTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKDYKTRDVTDDVK
SIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLGSKSAKIQSGIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQAIAYVM
LGNKAQTVLNGNLKVDFMETENSSSVKKQKALVAKVSQREEMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQ
IDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSSSRGPGRSAAEELDEEIPVSSHYFASKTRNERKRKKMPASQRSKRRKTAS

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>96824_96824_12_UNC45A-BLM_UNC45A_chr15_91493845_ENST00000418476_BLM_chr15_91298041_ENST00000560509_length(amino acids)=1734AA_BP=768
MTVSGPGTPEPRPATPGASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKAIEKDGG
DVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVV
LAREDAGAEKIFRSNGVQLLQRLLDMGETDLMLAALRTLVGICSEHQSRTVATLSILGTRRVVSILGVESQAVSLAACHLLQVMFDALKE
GVKKGFRGKEGAIIVDPARELKVLISNLLDLLTEVGVSGQGRDNALTLLIKAVPRKSLKDPNNSLTLWVIDQGLKKILEVGGSLQDPPGE
LAVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEQ
EEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKCSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQID
AGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSRLEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPS
FVRARVKKLLAAGVVSAMVCMVKTESPVLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGRALIPLALEGTDVGQTKAAQALAKLTITSN
PEMTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQELNPETSTDCD
ARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEGDSCPTGNSMKE
LNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASIND
LERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSESIQNYTDKSAQ
NLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVD
QVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYK
RMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECD
TMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLF
YTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKDYKTRDVTDDVK
SIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSS
SRGPGRSAAEELDEEIPVSSHYFASKTRNERKRKKMPASQRSKRRKTASSGSKAKGGSATCRKISSKTKSSSIIGSSSASHTSQATSGAN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:91493845/chr15:91298041)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BLM

Q13867

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUNC45Achr15:91483703chr15:91358332ENST00000394275+92321_54214.0930.0RepeatNote=TPR 1
HgeneUNC45Achr15:91483703chr15:91358332ENST00000394275+92358_91214.0930.0RepeatNote=TPR 2
HgeneUNC45Achr15:91483703chr15:91358332ENST00000394275+92392_125214.0930.0RepeatNote=TPR 3
HgeneUNC45Achr15:91483703chr15:91358332ENST00000418476+62021_54229.0945.0RepeatNote=TPR 1
HgeneUNC45Achr15:91483703chr15:91358332ENST00000418476+62058_91229.0945.0RepeatNote=TPR 2
HgeneUNC45Achr15:91483703chr15:91358332ENST00000418476+62092_125229.0945.0RepeatNote=TPR 3
HgeneUNC45Achr15:91493845chr15:91298040ENST00000394275+202321_54752.6666666666666930.0RepeatNote=TPR 1
HgeneUNC45Achr15:91493845chr15:91298040ENST00000394275+202358_91752.6666666666666930.0RepeatNote=TPR 2
HgeneUNC45Achr15:91493845chr15:91298040ENST00000394275+202392_125752.6666666666666930.0RepeatNote=TPR 3
HgeneUNC45Achr15:91493845chr15:91298040ENST00000418476+172021_54767.6666666666666945.0RepeatNote=TPR 1
HgeneUNC45Achr15:91493845chr15:91298040ENST00000418476+172058_91767.6666666666666945.0RepeatNote=TPR 2
HgeneUNC45Achr15:91493845chr15:91298040ENST00000418476+172092_125767.6666666666666945.0RepeatNote=TPR 3
HgeneUNC45Achr15:91493845chr15:91298041ENST00000394275+202321_54752.6666666666666930.0RepeatNote=TPR 1
HgeneUNC45Achr15:91493845chr15:91298041ENST00000394275+202358_91752.6666666666666930.0RepeatNote=TPR 2
HgeneUNC45Achr15:91493845chr15:91298041ENST00000394275+202392_125752.6666666666666930.0RepeatNote=TPR 3
HgeneUNC45Achr15:91493845chr15:91298041ENST00000418476+172021_54767.6666666666666945.0RepeatNote=TPR 1
HgeneUNC45Achr15:91493845chr15:91298041ENST00000418476+172058_91767.6666666666666945.0RepeatNote=TPR 2
HgeneUNC45Achr15:91493845chr15:91298041ENST00000418476+172092_125767.6666666666666945.0RepeatNote=TPR 3
TgeneBLMchr15:91493845chr15:91298040ENST00000355112322557_566319.66666666666671418.0Compositional biasNote=Poly-Asp
TgeneBLMchr15:91493845chr15:91298041ENST00000355112322557_566319.66666666666671418.0Compositional biasNote=Poly-Asp
TgeneBLMchr15:91493845chr15:91298040ENST000003551123221212_1292319.66666666666671418.0DomainHRDC
TgeneBLMchr15:91493845chr15:91298040ENST00000355112322676_851319.66666666666671418.0DomainHelicase ATP-binding
TgeneBLMchr15:91493845chr15:91298040ENST00000355112322877_1024319.66666666666671418.0DomainHelicase C-terminal
TgeneBLMchr15:91493845chr15:91298041ENST000003551123221212_1292319.66666666666671418.0DomainHRDC
TgeneBLMchr15:91493845chr15:91298041ENST00000355112322676_851319.66666666666671418.0DomainHelicase ATP-binding
TgeneBLMchr15:91493845chr15:91298041ENST00000355112322877_1024319.66666666666671418.0DomainHelicase C-terminal
TgeneBLMchr15:91493845chr15:91298040ENST000003551123221334_1349319.66666666666671418.0MotifNuclear localization signal
TgeneBLMchr15:91493845chr15:91298040ENST00000355112322795_798319.66666666666671418.0MotifNote=DEAH box
TgeneBLMchr15:91493845chr15:91298041ENST000003551123221334_1349319.66666666666671418.0MotifNuclear localization signal
TgeneBLMchr15:91493845chr15:91298041ENST00000355112322795_798319.66666666666671418.0MotifNote=DEAH box
TgeneBLMchr15:91493845chr15:91298040ENST00000355112322668_672319.66666666666671418.0Nucleotide bindingATP
TgeneBLMchr15:91493845chr15:91298040ENST00000355112322692_696319.66666666666671418.0Nucleotide bindingATP
TgeneBLMchr15:91493845chr15:91298041ENST00000355112322668_672319.66666666666671418.0Nucleotide bindingATP
TgeneBLMchr15:91493845chr15:91298041ENST00000355112322692_696319.66666666666671418.0Nucleotide bindingATP
TgeneBLMchr15:91493845chr15:91298040ENST000003551123221000_1003319.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91493845chr15:91298040ENST000003551123221094_1139319.66666666666671418.0RegionDNA Holliday junction binding
TgeneBLMchr15:91493845chr15:91298040ENST000003551123221110_1112319.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91493845chr15:91298040ENST000003551123221121_1125319.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91493845chr15:91298040ENST000003551123221160_1166319.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91493845chr15:91298040ENST000003551123221227_1244319.66666666666671418.0RegionNecessary for ssDNA and DNA Holliday junction binding
TgeneBLMchr15:91493845chr15:91298040ENST00000355112322362_414319.66666666666671418.0RegionNecessary for dimerization and homooligomerization
TgeneBLMchr15:91493845chr15:91298040ENST00000355112322870_873319.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91493845chr15:91298040ENST00000355112322897_899319.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91493845chr15:91298041ENST000003551123221000_1003319.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91493845chr15:91298041ENST000003551123221094_1139319.66666666666671418.0RegionDNA Holliday junction binding
TgeneBLMchr15:91493845chr15:91298041ENST000003551123221110_1112319.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91493845chr15:91298041ENST000003551123221121_1125319.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91493845chr15:91298041ENST000003551123221160_1166319.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91493845chr15:91298041ENST000003551123221227_1244319.66666666666671418.0RegionNecessary for ssDNA and DNA Holliday junction binding
TgeneBLMchr15:91493845chr15:91298041ENST00000355112322362_414319.66666666666671418.0RegionNecessary for dimerization and homooligomerization
TgeneBLMchr15:91493845chr15:91298041ENST00000355112322870_873319.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91493845chr15:91298041ENST00000355112322897_899319.66666666666671418.0Region3' overhang DNA-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBLMchr15:91483703chr15:91358332ENST000003551122022292_2991358.66666666666671418.0Compositional biasNote=Poly-Asp
TgeneBLMchr15:91483703chr15:91358332ENST000003551122022310_3161358.66666666666671418.0Compositional biasNote=Poly-Ser
TgeneBLMchr15:91483703chr15:91358332ENST000003551122022557_5661358.66666666666671418.0Compositional biasNote=Poly-Asp
TgeneBLMchr15:91493845chr15:91298040ENST00000355112322292_299319.66666666666671418.0Compositional biasNote=Poly-Asp
TgeneBLMchr15:91493845chr15:91298040ENST00000355112322310_316319.66666666666671418.0Compositional biasNote=Poly-Ser
TgeneBLMchr15:91493845chr15:91298041ENST00000355112322292_299319.66666666666671418.0Compositional biasNote=Poly-Asp
TgeneBLMchr15:91493845chr15:91298041ENST00000355112322310_316319.66666666666671418.0Compositional biasNote=Poly-Ser
TgeneBLMchr15:91483703chr15:91358332ENST0000035511220221212_12921358.66666666666671418.0DomainHRDC
TgeneBLMchr15:91483703chr15:91358332ENST000003551122022676_8511358.66666666666671418.0DomainHelicase ATP-binding
TgeneBLMchr15:91483703chr15:91358332ENST000003551122022877_10241358.66666666666671418.0DomainHelicase C-terminal
TgeneBLMchr15:91483703chr15:91358332ENST0000035511220221334_13491358.66666666666671418.0MotifNuclear localization signal
TgeneBLMchr15:91483703chr15:91358332ENST000003551122022795_7981358.66666666666671418.0MotifNote=DEAH box
TgeneBLMchr15:91483703chr15:91358332ENST000003551122022668_6721358.66666666666671418.0Nucleotide bindingATP
TgeneBLMchr15:91483703chr15:91358332ENST000003551122022692_6961358.66666666666671418.0Nucleotide bindingATP
TgeneBLMchr15:91483703chr15:91358332ENST0000035511220221000_10031358.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91483703chr15:91358332ENST0000035511220221094_11391358.66666666666671418.0RegionDNA Holliday junction binding
TgeneBLMchr15:91483703chr15:91358332ENST0000035511220221110_11121358.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91483703chr15:91358332ENST0000035511220221121_11251358.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91483703chr15:91358332ENST0000035511220221160_11661358.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91483703chr15:91358332ENST0000035511220221227_12441358.66666666666671418.0RegionNecessary for ssDNA and DNA Holliday junction binding
TgeneBLMchr15:91483703chr15:91358332ENST000003551122022362_4141358.66666666666671418.0RegionNecessary for dimerization and homooligomerization
TgeneBLMchr15:91483703chr15:91358332ENST000003551122022870_8731358.66666666666671418.0Region3' overhang DNA-binding
TgeneBLMchr15:91483703chr15:91358332ENST000003551122022897_8991358.66666666666671418.0Region3' overhang DNA-binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
UNC45A
BLM


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to UNC45A-BLM


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to UNC45A-BLM


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource