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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:BICD2-JAK2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BICD2-JAK2
FusionPDB ID: 9708
FusionGDB2.0 ID: 9708
HgeneTgene
Gene symbol

BICD2

JAK2

Gene ID

23299

3717

Gene nameBICD cargo adaptor 2Janus kinase 2
SynonymsSMALED2|SMALED2A|SMALED2B|bA526D8.1JTK10|THCYT3
Cytomap

9q22.31

9p24.1

Type of geneprotein-codingprotein-coding
Descriptionprotein bicaudal D homolog 2bic-D 2bicaudal D homolog 2coiled-coil protein BICD2cytoskeleton-like bicaudal D protein homolog 2homolog of Drosophila bicaudal Dtyrosine-protein kinase JAK2JAK-2Janus kinase 2 (a protein tyrosine kinase)
Modification date2020031320200329
UniProtAcc

Q8TD16

O60674

Ensembl transtripts involved in fusion geneENST idsENST00000375512, ENST00000356884, 
ENST00000487310, ENST00000381652, 
ENST00000539801, ENST00000544510, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 5 X 4=12022 X 26 X 9=5148
# samples 615
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/5148*10)=-5.10097764772482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: BICD2 [Title/Abstract] AND JAK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneJAK2

GO:0010811

positive regulation of cell-substrate adhesion

10925297

TgeneJAK2

GO:0019221

cytokine-mediated signaling pathway

8609418

TgeneJAK2

GO:0033209

tumor necrosis factor-mediated signaling pathway

8609418

TgeneJAK2

GO:0034612

response to tumor necrosis factor

8609418

TgeneJAK2

GO:0035409

histone H3-Y41 phosphorylation

19783980

TgeneJAK2

GO:0035722

interleukin-12-mediated signaling pathway

7528775

TgeneJAK2

GO:0046677

response to antibiotic

16280321

TgeneJAK2

GO:0050727

regulation of inflammatory response

10925297

TgeneJAK2

GO:0060396

growth hormone receptor signaling pathway

10925297

TgeneJAK2

GO:0070671

response to interleukin-12

7528775


check buttonFusion gene breakpoints across BICD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across JAK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..BICD2chr9

95477535

-JAK2chr9

5072492

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375512BICD2chr995477535-ENST00000539801JAK2chr95072492+431825372642941422
ENST00000375512BICD2chr995477535-ENST00000381652JAK2chr95072492+568725372642941422
ENST00000375512BICD2chr995477535-ENST00000544510JAK2chr95072492+435325372642941422

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>9708_9708_1_BICD2-JAK2_BICD2_chr9_95477535_ENST00000375512_JAK2_chr9_5072492_ENST00000381652_length(amino acids)=1422AA_BP=837
MREPQWEPAQPSATMSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEME
QLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDD
IKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNS
LRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQ
KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILA
CKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE
LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP
LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEV
ALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRL
ELLELDHEQTRRGRAKAAPKTKPATPSNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLV
LNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDP
GISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDY
EPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

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>9708_9708_2_BICD2-JAK2_BICD2_chr9_95477535_ENST00000375512_JAK2_chr9_5072492_ENST00000539801_length(amino acids)=1422AA_BP=837
MREPQWEPAQPSATMSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEME
QLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDD
IKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNS
LRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQ
KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILA
CKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE
LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP
LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEV
ALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRL
ELLELDHEQTRRGRAKAAPKTKPATPSNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLV
LNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDP
GISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDY
EPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>9708_9708_3_BICD2-JAK2_BICD2_chr9_95477535_ENST00000375512_JAK2_chr9_5072492_ENST00000544510_length(amino acids)=1422AA_BP=837
MREPQWEPAQPSATMSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEME
QLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDD
IKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNS
LRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQ
KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILA
CKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE
LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP
LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEV
ALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRL
ELLELDHEQTRRGRAKAAPKTKPATPSNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLV
LNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDP
GISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDY
EPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:/chr9:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BICD2

Q8TD16

JAK2

O60674

FUNCTION: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25962623}.FUNCTION: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980). {ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:21368206, ECO:0000269|PubMed:21423214, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:9618263}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (915)CIF file (915) >>>915.cifBICD2chr995477535-JAK2chr95072492+
MREPQWEPAQPSATMSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAET
TREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAH
TNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQ
SENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE
ENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEIS
ERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFS
DDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDL
LSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEK
VTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILA
CKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVS
LLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELAN
LYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILL
PKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRD
QIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTK
REQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKAL
KEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAI
QQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSNESLGQGTFTKIF
KGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLV
LNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKD
ILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQ
RKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNF
GSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNI
VKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKV
KEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE
FMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNV
1422
3D view using mol* of 915 (AA BP:)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
BICD2_pLDDT.png
all structure
JAK2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
BICD2_JAK2_915_pLDDT_and_active_sites.png (AA BP:)
all structure
BICD2_JAK2_915_violinplot.png (AA BP:)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
9151.041881.018456.8760.5070.75810.6041.1570.5220.74Chain A: 841,842,844,845,847,849,869,871,900,916,9
18,919,921,922,923,925,926,927,930,962,963,965,966
,967,968,970,988,989,990,991,992,994,1001,1004,100
5,1008,1009,1028,1035,1042,1043,1045,1047,1052

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
915ZINC000000000850DB00744Zileuton-7.38277-7.40137
915ZINC000014210876DB09272Eluxadoline-5.8393-7.2709
915ZINC000043100953DB09042Tedizolid phosphate-7.17581-7.26081
915ZINC000000018635DB00998Frovatriptan-7.16921-7.16971
915ZINC000000057147DB00651Dyphylline-7.15776-7.15776
915ZINC000001530636DB00927Famotidine-5.8746-7.0533
915ZINC000001886617DB01095Fluvastatin-6.98089-6.98269
915ZINC000000001735DB00350Minoxidil-6.91095-6.91095
915ZINC000049637509DB06636Isavuconazonium-4.96446-6.86916
915BelumosudilDB06636-6.82346-6.83116
915ZINC000001530600DB00369Cidofovir-6.24465-6.79795
915ZINC000003775644DB01123Proflavine-6.6114-6.6422
915ZINC000009212427DB11596Levoleucovorin-6.62715-6.62725
915ZINC000013818943DB06213Regadenoson-6.61849-6.61849
915ZINC000000896918DB01144Diclofenamide-6.57971-6.58701
915ZINC000000006481DB00740Riluzole-6.55562-6.55562
915ZINC000009212428DB11596Levoleucovorin-6.52979-6.52989
915ZINC000000009073DB00714Apomorphine-6.47236-6.51626
915ZINC000003842753DB00432Trifluridine-6.42934-6.51404
915ZINC000000002055DB08797Salicylamide-4.85598-6.50298

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000014210876DB09272EluxadolineSmall moleculeCOC1=CC=C(CN([C@@H](C)C2=NC(=CN2)C2=CC=CC=C2)C(=O)[C@@H](N)CC2=C(C)C=C(C=C2C)C(N)=O)C=C1C(O)=OApproved|Investigational
ZINC000043100953DB09042Tedizolid phosphateSmall moleculeCN1N=NC(=N1)C1=CC=C(C=N1)C1=CC=C(C=C1F)N1C[C@H](COP(O)(O)=O)OC1=OApproved
ZINC000000018635DB00998FrovatriptanSmall moleculeCN[C@@H]1CCC2=C(C1)C1=C(N2)C=CC(=C1)C(N)=OApproved|Investigational
ZINC000000057147DB00651DyphyllineSmall moleculeCN1C2=C(N(CC(O)CO)C=N2)C(=O)N(C)C1=OApproved
ZINC000001530636DB00927FamotidineSmall moleculeNC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1Approved
ZINC000001886617DB01095FluvastatinSmall moleculeCC(C)N1C(C=C[C@H](O)C[C@H](O)CC(O)=O)=C(C2=CC=C(F)C=C2)C2=CC=CC=C12Approved
ZINC000000001735DB00350MinoxidilSmall moleculeNC1=CC(=NC(N)=[N+]1[O-])N1CCCCC1Approved|Investigational
ZINC000049637509DB06636IsavuconazoniumSmall molecule[H]C(C)(OC(=O)N(C)C1=C(COC(=O)CNC)C=CC=N1)[N+]1=CN(C[C@](O)(C2=C(F)C=CC(F)=C2)[C@@]([H])(C)C2=NC(=CS2)C2=CC=C(C=C2)C#N)N=C1Approved|Investigational
ZINC000001530600DB00369CidofovirSmall moleculeNC1=NC(=O)N(C[C@@H](CO)OCP(O)(O)=O)C=C1Approved
ZINC000003775644DB01123ProflavineSmall moleculeNC1=CC2=NC3=C(C=CC(N)=C3)C=C2C=C1Approved
ZINC000009212427DB11596LevoleucovorinSmall moleculeNC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2C=O)N1Approved|Investigational
ZINC000013818943DB06213RegadenosonSmall moleculeCNC(=O)C1=CN(N=C1)C1=NC2=C(N=CN2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C(N)=N1Approved|Investigational
ZINC000000896918DB01144DiclofenamideSmall moleculeNS(=O)(=O)C1=CC(=C(Cl)C(Cl)=C1)S(N)(=O)=OApproved|Investigational
ZINC000000006481DB00740RiluzoleSmall moleculeNC1=NC2=C(S1)C=C(OC(F)(F)F)C=C2Approved|Investigational
ZINC000000009073DB00714ApomorphineSmall molecule[H][C@]12CC3=C(C(O)=C(O)C=C3)C3=CC=CC(CCN1C)=C23Approved|Investigational
ZINC000003842753DB00432TrifluridineSmall moleculeOC[C@H]1O[C@H](C[C@@H]1O)N1C=C(C(=O)NC1=O)C(F)(F)FApproved|Investigational
ZINC000000002055DB08797SalicylamideSmall moleculeNC(=O)C1=CC=CC=C1OApproved

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000000000850236.2885.297457.64285.783137.035198.52336.3755.01533.78.91375.35100
ZINC000000000850236.2885.297450.83785.532135.419201.89327.994746.83933.78.57376.55500
ZINC000014210876569.6597.127866.349287.048259.904319.39701681.617610.758.68917.53822
ZINC000014210876569.6593.679901.19287.315271.102342.77301718.172610.758.88816.54622
ZINC000014210876569.6596.683902.919270.324282.937349.65801740.575610.758.9214.83122
ZINC000014210876569.6596.148862.573279.279281.556301.73701689.73610.758.98413.05322
ZINC000014210876569.65914.843858.111275.061269.062313.98801679.1610.759.13316.01322
ZINC000014210876569.65914.363896.983280.954265.963350.06601717.668610.759.0117.35222
ZINC000043100953450.3228.428720.625174.492308.419199.97437.7411252.9792139.192117.34511
ZINC000043100953450.3228.806708.392174.655291.009204.37638.3521241.0022139.026120.70611
ZINC000000018635243.3087.2492.762217.467154.534120.7610833.223448.296366.4100
ZINC000000057147254.2455.711471.42234.45192.15644.8140796.57528.49.04363.75300
ZINC000001530636337.4328.496521.83399.501273.3951.82697.115914.026798.5235.23410
ZINC000001530636337.43213.115494.303116.816261.31243.15673.019882.5675.58.82239.67810
ZINC000001530636337.4326.659521.267100.72277.97650.89391.678913.905798.611234.15111
ZINC000001530636337.43211.671559.823101.56332.16638.03588.062950.185798.602223.15711
ZINC000001530636337.4328.716590.73582.084369.40446.6192.637969.1575.58.538220.34511
ZINC000001530636337.4323.147583.852100.402354.87439.07989.497971.384798.705218.77711
ZINC000001886617411.4725.013697.101243.2165.521241.76846.6121293.66524.48.26277.29910
ZINC000000001735209.255.141437.436217.593169.97449.8690711.86443.57.733376.87300
ZINC000001530600279.18910.973485.753106.478301.21375.1182.945819.936512.48.977118.28601
ZINC000001530600279.18913.189481.116107.174307.99561.4654.483817.63512.48.916116.85501
ZINC000003775644209.250.181433.0810137.936295.1440706.541337.603383.63700
ZINC000003775644209.250.371432.1120138.151293.9610705.014337.627383.53500
ZINC000009212427473.44416.012788.553155.209480.878152.46601386.2177.2514.258.2841021
ZINC000013818943390.3589.438610.126176.989300.388132.74901099.984614.38.883211.79121
ZINC000000896918305.1510.441443.5210273.16657.876112.48726.0574910.38245.40200
ZINC000000896918305.1510.449439.5840269.35956.169114.056719.1544910.18246.05600
ZINC000000006481234.1965.283393.4351.90387.083133.293171.157623.3228.622310000
ZINC000009212428473.44414.445779.113159.973464.37154.7701374.8037.2514.258.2671021
ZINC000000009073267.3272.782497.054198.41689.209209.4290864.1823.58.732385.24200
ZINC000000009073267.3273.056495.924195.69289.933210.30861.91423.58.758385.01500
ZINC000000009073267.3272.7496.286197.17288.825210.2890858.90623.58.722385.13100
ZINC000003842753296.2038.671452.2125.183206.5539.446111.018773.03338.610.189361.74800
ZINC000003842753296.2036.973450.843125.482197.47913.613114.268769.6938.610.058363.65500
ZINC000000002055137.1386.473320.9890148.306172.6830487.38922.259.228380.82200
ZINC000000002055137.1385.405320.1410149.757170.3840487.07322.259.337380.50600


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000000000850C[C@@H](c1cc2ccccc2s1)N(O)C(N)=O0.1363358820.223511692
ZINC000014210876COc1ccc(CN(C(=O)[C@@H](N)Cc2c(C)cc(C(N)=O)cc2C)[C@@H](C)c2nc(-c3ccccc3)c[nH]2)cc1C(=O)O0.0678197430.140534867
ZINC000043100953Cn1nnc(-c2ccc(-c3ccc(N4C[C@H](COP(=O)(O)O)OC4=O)cc3F)cn2)n10.0928451070.135775423
ZINC000000018635CN[C@@H]1CCc2[nH]c3ccc(C(N)=O)cc3c2C10.156787310.476568578
ZINC000000057147Cn1c(=O)c2c(ncn2C[C@@H](O)CO)n(C)c1=O0.1431708550.263526965
ZINC000001530636N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs10.0885838660.372327259
ZINC000001886617CC(C)n1c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)O)c(-c2ccc(F)cc2)c2ccccc210.1011703060.183209327
ZINC000000001735Nc1cc(N2CCCCC2)nc(N)[n+]1[O-]0.1297409460.395964399
ZINC000049637509CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c10.0254160270.235213823
ZINC000001530600Nc1ccn(C[C@@H](CO)OCP(=O)(O)O)c(=O)n10.0801497210.307248667
ZINC000003775644Nc1ccc2cc3ccc(N)cc3nc2c10.3467620850.473171062
ZINC000009212427Nc1nc2c(c(=O)[nH]1)N(C=O)[C@@H](CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)CN20.0637430910.499740832
ZINC000013818943CNC(=O)c1cnn(-c2nc(N)c3ncn([C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)c3n2)c10.0569500780.195718995
ZINC000000896918NS(=O)(=O)c1cc(Cl)c(Cl)c(S(N)(=O)=O)c10.2656679410.432760441
ZINC000000006481Nc1nc2ccc(OC(F)(F)F)cc2s10.2910020260.384188974
ZINC000009212428Nc1nc2c(c(=O)[nH]1)N(C=O)[C@H](CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)CN20.0637430910.499740832
ZINC000000009073CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-30.1403815320.423432224
ZINC000003842753O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1C(F)(F)F0.0733993370.470521911
ZINC000000002055NC(=O)c1ccccc1O0.5617461260.479667743


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
BICD2ACTR1A, DCTN2, DYNC1H1, RAB6A, ZRANB1, PLK1, Ranbp2, Ndc80, Plk1, gag-pol, DYNC1I1, DCTN1, DYNC1LI1, PAFAH1B1, ALK, ORC6, CORO1A, C17orf59, NEK9, HERC2, PCM1, CEP128, XPO1, PMF1, UNC5CL, MIS18A, NEFL, TCP10L, CCDC53, COG6, CAPN6, CPNE5, TRIM14, KIAA1429, DYNC1I2, DYNC1LI2, BICD1, FAM83B, TMEM201, TMEM57, USP53, BICD2, TTC17, CCDC138, USP54, SIPA1L3, TMEM131, MIB1, PLEC, CEP170B, TNRC6A, RANBP2, KPNB1, EIF4ENIF1, PKD1L1, CENPE, NEURL4, GPATCH1, TJP2, CEP55, NUP88, TAB1, ALMS1, MAST2, LRCH2, ARF3, RGPD1, TANC1, DIS3L, ABI2, CAPZA1, CAPZB, NUP62, CEP192, HSPD1, RANGAP1, SVIL, SYNJ2, KIAA1671, LUZP1, IFT22, ARFGAP3, ARHGAP1, ARHGAP12, ATG13, BORA, C17orf53, C20orf27, C2CD3, CASP9, CEP41, CUL3, DPH5, DPYSL4, ERC1, GDI2, GRIPAP1, ADRBK1, KIAA1217, KIF7, KLHL22, KLHL9, LASP1, LCP1, MTMR14, MTMR2, MVB12A, PDLIM7, PIBF1, PIN1, PLEKHA7, PLS3, POC5, RINL, RTKN, SH2D4A, SNX4, STXBP5, SUFU, TRIP6, ZC2HC1A, PDLIM5, CC2D1A, SYNJ1, ST7, CTTN, DNMBP, PDLIM3, GPBP1, MAP4K3, SORBS1, TNIK, SNCA, CALD1, SLAIN2, DBNL, EFHD2, TSR1, BCCIP, TES, ANXA2, SEPT7, PDAP1, HSD17B4, ATP6V1A, SEPT9, ZC3H7A, ECE1, IST1, BIN3, WDR18, EIF5A, OCRL, PXN, ARPC2, SNX9, NFKB1, TRDMT1, ALDH1A2, EPS8, MTMR9, SH3PXD2B, SH3GL1, TPD52L2, MAP7D2, EIF4B, TANK, PPP2R3A, PAWR, PPIP5K2, USP15, TXLNG, GAMT, CCDC50, TFCP2, CORO1B, PARD3B, HN1L, MTMR6, PPP1R2, TTC1, UBAP1, BAIAP2, GPN1, LIMD1, TRIM25, NAP1L1, CSNK1E, CSNK1D, PEBP1, NFX1, PDLIM1, ARPC5, CNN2, FOXO3, PIH1D1, PPP1R8, EXOSC2, LTV1, NEDD1, NCKAP1, EDF1, ANKS1A, PCMT1, OCIAD1, NAP1L4, FHL1, HSPH1, RPS6KB1, PSME1, LSM12, NMT1, FCHO2, PPP1R7, PAIP1, SEPT6, COPZ1, NDC80, DPYSL5, MAGI3, IBTK, ARFGAP2, AAK1, CNN3, CIAPIN1, MICALL1, CARD8, CD2AP, PTPN23, CDV3, FPGS, FXR2, AVEN, NUDT5, NCDN, WASL, TBK1, ABL2, NUP43, ACTR3, TBCE, SERBP1, VCL, CHORDC1, ZNF598, PDCL3, C1orf198, ENAH, SEPT8, PGAM1, DPYSL2, DOCK4, KATNB1, RRM2, DPYSL3, ASAP1, HBS1L, BSDC1, CRTC1, CSDE1, CCDC85C, EIF2A, DDX3X, RPP25L, SUGT1, ARFIP2, EIF4H, PATL1, TJP1, RPAP3, MLLT4, CAMSAP2, PPP2R5D, EIF3G, CAMSAP1, ITSN1, STAT3, NFATC3, FERMT2, PIN4, TBCB, VAPB, RAPH1, TAB2, MAP4K4, ARPC3, WRAP73, EXOSC6, UBE2M, WASF2, CLINT1, TTF2, BAIAP2L1, PCBP1, EXOSC7, TLN1, KIAA0355, PTPN14, EIF2D, KIAA1191, ZNF185, TAB3, MAPRE1, SASS6, PCBP2, NIN, VRK3, DYRK1A, LRRK2, USP2, HDAC4, LNX1, DCX, RBM41, POLDIP3, SNW1, PRPF31, ZC2HC1C, FAM110A, TBRG4, MFAP1, FAM50B, ZMAT2, PPP1R18, RAB6B, FAM161B, ZSCAN12, CBR3, PRPF18, FAM161A, TCEA2, MOS, ZNF417, TSGA10IP, YES1, TCEANC, ZNF648, HMHA1, ZSCAN23, ZNF669, ZNF624, CCHCR1, UTP14C, MGC50722, ZNF670, MAST4, HIST1H1A, ARHGEF15, TSPAN15, HIST2H2BE, KIF2B, DNAH5, HIST2H3PS2, HIST1H1E, HIST1H1C, HIST3H3, HIST1H2BH, HIST1H1B, nsp7, CEP135, CLTB, KRT18, KRT8, NEFM, PRPH, RAB11A, SYNE3, VIM, ZBTB2, WHAMMP3, RGPD8, VPS41, SYCE1, C1orf123, KXD1, FLAD1, BFSP1, IL17F, TENC1, MBNL1, VPS18, COPS3, UBR3, RGPD5, VPS33A, YTHDF1, PRPF6, TFIP11, PRC1, UTP14A, NXF1, RBM22, FBXO32,
JAK2PRMT5, SOCS1, PPIA, IL12RB2, EPOR, FYN, STAT5A, STAT5B, SH2B2, CXCR4, DNAJA3, HSPA8, TEC, PTPN12, PTK2, CSF2RB, GHR, VAV1, SIRPA, IRS1, BRCA1, GRB2, EGFR, PTK2B, PTPN11, TNFRSF1A, SOCS3, PTPN6, LYN, HTR2A, ERBB2, ELP2, KIT, RAF1, SH2B1, IL5RA, PPP2R1B, IFNGR1, IFNGR2, CCR5, PRLR, IL6ST, SHC1, GRB10, TUB, TSHR, STAT3, INSR, STAM, PTPN1, STAM2, IL2RB, CTLA4, ALK, IKBKG, FGFR1, STAT1, HSP90AA1, HSP90AB1, ASB2, SKP2, GTF2I, HIST3H3, HIST2H3C, CDKN1B, VHL, PIK3R1, MAP3K5, AGTR1, PTAFR, JAK2, IL4R, IL2RG, PPP1CC, ERBB3, CALM1, SRC, JAK3, PLCG1, HES1, HES5, Ifngr1, ASS1, RBMX, TRAF6, EZH2, DTX3L, EMD, KPNB1, NAP1L1, RCN1, SLC2A1, UBP1, ARL11, HSFY1, HDAC6, HNRNPL, CBL, RNF123, Lmo4, GOLPH3, IGF1R, PARP9, LNX1, LDOC1, CSK, MPL, CUL4A, CUL4B, M, JAK1, AMY1C, BPIFA2, ARHGAP18, BACH1, IGHA2, HMMR, MUC7, CST2, IGJ, PBK, MUC5B, SPRR3, ZG16B, VCP,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
BICD2all structure
JAK2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to BICD2-JAK2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to BICD2-JAK2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBICD2C4747715SPINAL MUSCULAR ATROPHY, LOWER EXTREMITY-PREDOMINANT, 2A, CHILDHOOD ONSET, AUTOSOMAL DOMINANT5GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneBICD2C4749003SPINAL MUSCULAR ATROPHY, LOWER EXTREMITY-PREDOMINANT, 2B, PRENATAL ONSET, AUTOSOMAL DOMINANT3GENOMICS_ENGLAND;UNIPROT
HgeneBICD2C0003886Arthrogryposis1GENOMICS_ENGLAND
HgeneBICD2C0020305Hydrops Fetalis1GENOMICS_ENGLAND
HgeneBICD2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneBICD2C0033999Pterygium1GENOMICS_ENGLAND
HgeneBICD2C0235659Reduced fetal movement1GENOMICS_ENGLAND
TgeneJAK2C0032463Polycythemia Vera12CTD_human;ORPHANET;UNIPROT
TgeneJAK2C0040028Thrombocythemia, Essential10CTD_human;ORPHANET
TgeneJAK2C0001815Primary Myelofibrosis9CGI;CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneJAK2C3489628Thrombocytosis, Autosomal Dominant8CTD_human
TgeneJAK2C0019154Hepatic Vein Thrombosis3CTD_human;ORPHANET
TgeneJAK2C0856761Budd-Chiari Syndrome3CTD_human;ORPHANET
TgeneJAK2C0009324Ulcerative Colitis2CTD_human
TgeneJAK2C0027022Myeloproliferative disease2CTD_human
TgeneJAK2C0151744Myocardial Ischemia2CTD_human
TgeneJAK2C0836924Thrombocytosis2CTD_human
TgeneJAK2C3281125THROMBOCYTHEMIA 32UNIPROT
TgeneJAK2C0000786Spontaneous abortion1CTD_human
TgeneJAK2C0000822Abortion, Tubal1CTD_human
TgeneJAK2C0006663Calcinosis1CTD_human
TgeneJAK2C0007873Uterine Cervical Neoplasm1CTD_human
TgeneJAK2C0018824Heart valve disease1CTD_human
TgeneJAK2C0019207Hepatoma, Morris1CTD_human
TgeneJAK2C0019208Hepatoma, Novikoff1CTD_human
TgeneJAK2C0021368Inflammation1CTD_human
TgeneJAK2C0023418leukemia1CTD_human
TgeneJAK2C0023467Leukemia, Myelocytic, Acute1CGI;CTD_human;UNIPROT
TgeneJAK2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneJAK2C0023904Liver Neoplasms, Experimental1CTD_human
TgeneJAK2C0025472Mesenteric Vascular Occlusion1CTD_human
TgeneJAK2C0026998Acute Myeloid Leukemia, M11CTD_human
TgeneJAK2C0032461Polycythemia1CTD_human
TgeneJAK2C0032962Pregnancy Complications1CTD_human
TgeneJAK2C0033578Prostatic Neoplasms1CTD_human
TgeneJAK2C0040038Thromboembolism1CTD_human
TgeneJAK2C0042487Venous Thrombosis1CTD_human
TgeneJAK2C0086404Experimental Hepatoma1CTD_human
TgeneJAK2C0149871Deep Vein Thrombosis1CTD_human
TgeneJAK2C0263628Tumoral calcinosis1CTD_human
TgeneJAK2C0376358Malignant neoplasm of prostate1CTD_human
TgeneJAK2C0400966Non-alcoholic Fatty Liver Disease1CTD_human
TgeneJAK2C0521174Microcalcification1CTD_human
TgeneJAK2C1527405Erythrocytosis1CTD_human
TgeneJAK2C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneJAK2C3241937Nonalcoholic Steatohepatitis1CTD_human
TgeneJAK2C3495676Anorectal Malformations1GENOMICS_ENGLAND
TgeneJAK2C3830362Early Pregnancy Loss1CTD_human
TgeneJAK2C4048328cervical cancer1CTD_human
TgeneJAK2C4303761Familial thrombocytosis1ORPHANET
TgeneJAK2C4552766Miscarriage1CTD_human