UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:BID-ATP6V1E1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: BID-ATP6V1E1
	FusionPDB ID: 9720
	FusionGDB2.0 ID: 9720
		Hgene	Tgene
	Gene symbol	BID	ATP6V1E1
	Gene ID	637	529
	Gene name	BH3 interacting domain death agonist	ATPase H+ transporting V1 subunit E1
	Synonyms	FP497	ARCL2C\|ATP6E\|ATP6E2\|ATP6V1E\|P31\|Vma4
	Cytomap	22q11.21	22q11.21
	Type of gene	protein-coding	protein-coding
	Description	BH3-interacting domain death agonistBH3 interacting domain death agonist Si6 isoformBID isoform ES(1b)BID isoform L(2)BID isoform Si6Human BID coding sequenceapoptic death agonistdesmocollin type 4p22 BID	V-type proton ATPase subunit E 1ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1H(+)-transporting two-sector ATPase, 31kDa subunitH+-transporting ATP synthase chain E, vacuolarV-ATPase 31 kDa subunitV-ATPase subunit E 1V-ATPase, subunit Evac
	Modification date	20200313	20200313
	UniProtAcc	P55957	P36543
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000342111, ENST00000317361, ENST00000399765, ENST00000399767, ENST00000399774, ENST00000551952, ENST00000473439,	ENST00000253413, ENST00000399796, ENST00000399798, ENST00000478963,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 7 X 4=196	7 X 8 X 4=224
	# samples	9	10
	** MAII score	log2(9/196*10)=-1.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/224*10)=-1.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: BID [Title/Abstract] AND ATP6V1E1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ATP6V1E1(18095578)-BID(18226779), # samples:1 BID(18220783)-ATP6V1E1(18096086), # samples:1 BID(18220782)-ATP6V1E1(18096086), # samples:1
Anticipated loss of major functional domain due to fusion event.	BID-ATP6V1E1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BID-ATP6V1E1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BID-ATP6V1E1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BID-ATP6V1E1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BID-ATP6V1E1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. BID-ATP6V1E1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. BID-ATP6V1E1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BID	GO:0001836	release of cytochrome c from mitochondria	17052454
Hgene	BID	GO:0031334	positive regulation of protein complex assembly	19074440\|21041309
Hgene	BID	GO:0090150	establishment of protein localization to membrane	21041309

Fusion gene breakpoints across BID (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATP6V1E1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-BC-4073-01B	BID	chr22	18220783	-	ATP6V1E1	chr22	18096086	-
ChimerDB4	LIHC	TCGA-BC-4073	BID	chr22	18220782	-	ATP6V1E1	chr22	18096086	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000317361	BID	chr22	18220783	-	ENST00000253413	ATP6V1E1	chr22	18096086	-	2161	1041	231	1622	463
ENST00000317361	BID	chr22	18220783	-	ENST00000399796	ATP6V1E1	chr22	18096086	-	2038	1041	231	1532	433
ENST00000317361	BID	chr22	18220783	-	ENST00000399798	ATP6V1E1	chr22	18096086	-	1888	1041	231	1622	463
ENST00000551952	BID	chr22	18220783	-	ENST00000253413	ATP6V1E1	chr22	18096086	-	1780	660	6	1241	411
ENST00000551952	BID	chr22	18220783	-	ENST00000399796	ATP6V1E1	chr22	18096086	-	1657	660	6	1151	381
ENST00000551952	BID	chr22	18220783	-	ENST00000399798	ATP6V1E1	chr22	18096086	-	1507	660	6	1241	411
ENST00000317361	BID	chr22	18220782	-	ENST00000253413	ATP6V1E1	chr22	18096086	-	2161	1041	231	1622	463
ENST00000317361	BID	chr22	18220782	-	ENST00000399796	ATP6V1E1	chr22	18096086	-	2038	1041	231	1532	433
ENST00000317361	BID	chr22	18220782	-	ENST00000399798	ATP6V1E1	chr22	18096086	-	1888	1041	231	1622	463
ENST00000551952	BID	chr22	18220782	-	ENST00000253413	ATP6V1E1	chr22	18096086	-	1780	660	6	1241	411
ENST00000551952	BID	chr22	18220782	-	ENST00000399796	ATP6V1E1	chr22	18096086	-	1657	660	6	1151	381
ENST00000551952	BID	chr22	18220782	-	ENST00000399798	ATP6V1E1	chr22	18096086	-	1507	660	6	1241	411

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000317361	ENST00000253413	BID	chr22	18220783	-	ATP6V1E1	chr22	18096086	-	0.002441922	0.9975581
ENST00000317361	ENST00000399796	BID	chr22	18220783	-	ATP6V1E1	chr22	18096086	-	0.002726432	0.9972736
ENST00000317361	ENST00000399798	BID	chr22	18220783	-	ATP6V1E1	chr22	18096086	-	0.004442811	0.99555725
ENST00000551952	ENST00000253413	BID	chr22	18220783	-	ATP6V1E1	chr22	18096086	-	0.002216047	0.99778396
ENST00000551952	ENST00000399796	BID	chr22	18220783	-	ATP6V1E1	chr22	18096086	-	0.002042678	0.99795735
ENST00000551952	ENST00000399798	BID	chr22	18220783	-	ATP6V1E1	chr22	18096086	-	0.002951219	0.9970488
ENST00000317361	ENST00000253413	BID	chr22	18220782	-	ATP6V1E1	chr22	18096086	-	0.002441922	0.9975581
ENST00000317361	ENST00000399796	BID	chr22	18220782	-	ATP6V1E1	chr22	18096086	-	0.002726432	0.9972736
ENST00000317361	ENST00000399798	BID	chr22	18220782	-	ATP6V1E1	chr22	18096086	-	0.004442811	0.99555725
ENST00000551952	ENST00000253413	BID	chr22	18220782	-	ATP6V1E1	chr22	18096086	-	0.002216047	0.99778396
ENST00000551952	ENST00000399796	BID	chr22	18220782	-	ATP6V1E1	chr22	18096086	-	0.002042678	0.99795735
ENST00000551952	ENST00000399798	BID	chr22	18220782	-	ATP6V1E1	chr22	18096086	-	0.002951219	0.9970488

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>9720_9720_1_BID-ATP6V1E1_BID_chr22_18220782_ENST00000317361_ATP6V1E1_chr22_18096086_ENST00000253413_length(amino acids)=463AA_BP=1
MNDPRGPWESSEALSHQVAGLARVHSFIQQIRMCSGAGVMMARWAARGRAGWRSTVRILSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLR
DECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIP
PGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARN
AEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQG
LYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRG

--------------------------------------------------------------

>9720_9720_2_BID-ATP6V1E1_BID_chr22_18220782_ENST00000317361_ATP6V1E1_chr22_18096086_ENST00000399796_length(amino acids)=433AA_BP=1
MNDPRGPWESSEALSHQVAGLARVHSFIQQIRMCSGAGVMMARWAARGRAGWRSTVRILSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLR
DECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIP
PGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARN
AEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIP

--------------------------------------------------------------

>9720_9720_3_BID-ATP6V1E1_BID_chr22_18220782_ENST00000317361_ATP6V1E1_chr22_18096086_ENST00000399798_length(amino acids)=463AA_BP=1
MNDPRGPWESSEALSHQVAGLARVHSFIQQIRMCSGAGVMMARWAARGRAGWRSTVRILSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLR
DECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIP
PGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARN
AEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQG
LYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRG

--------------------------------------------------------------

>9720_9720_4_BID-ATP6V1E1_BID_chr22_18220782_ENST00000551952_ATP6V1E1_chr22_18096086_ENST00000253413_length(amino acids)=411AA_BP=1
MKQSRKGSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRS
SHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALL
LAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLR
ARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPE

--------------------------------------------------------------

>9720_9720_5_BID-ATP6V1E1_BID_chr22_18220782_ENST00000551952_ATP6V1E1_chr22_18096086_ENST00000399796_length(amino acids)=381AA_BP=1
MKQSRKGSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRS
SHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALL
LAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLR
ARDDLITGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQ

--------------------------------------------------------------

>9720_9720_6_BID-ATP6V1E1_BID_chr22_18220782_ENST00000551952_ATP6V1E1_chr22_18096086_ENST00000399798_length(amino acids)=411AA_BP=1
MKQSRKGSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRS
SHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALL
LAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLR
ARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPE

--------------------------------------------------------------

>9720_9720_7_BID-ATP6V1E1_BID_chr22_18220783_ENST00000317361_ATP6V1E1_chr22_18096086_ENST00000253413_length(amino acids)=463AA_BP=1
MNDPRGPWESSEALSHQVAGLARVHSFIQQIRMCSGAGVMMARWAARGRAGWRSTVRILSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLR
DECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIP
PGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARN
AEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQG
LYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRG

--------------------------------------------------------------

>9720_9720_8_BID-ATP6V1E1_BID_chr22_18220783_ENST00000317361_ATP6V1E1_chr22_18096086_ENST00000399796_length(amino acids)=433AA_BP=1
MNDPRGPWESSEALSHQVAGLARVHSFIQQIRMCSGAGVMMARWAARGRAGWRSTVRILSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLR
DECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIP
PGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARN
AEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIP

--------------------------------------------------------------

>9720_9720_9_BID-ATP6V1E1_BID_chr22_18220783_ENST00000317361_ATP6V1E1_chr22_18096086_ENST00000399798_length(amino acids)=463AA_BP=1
MNDPRGPWESSEALSHQVAGLARVHSFIQQIRMCSGAGVMMARWAARGRAGWRSTVRILSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLR
DECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIP
PGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARN
AEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQG
LYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRG

--------------------------------------------------------------

>9720_9720_10_BID-ATP6V1E1_BID_chr22_18220783_ENST00000551952_ATP6V1E1_chr22_18096086_ENST00000253413_length(amino acids)=411AA_BP=1
MKQSRKGSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRS
SHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALL
LAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLR
ARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPE

--------------------------------------------------------------

>9720_9720_11_BID-ATP6V1E1_BID_chr22_18220783_ENST00000551952_ATP6V1E1_chr22_18096086_ENST00000399796_length(amino acids)=381AA_BP=1
MKQSRKGSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRS
SHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALL
LAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLR
ARDDLITGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQ

--------------------------------------------------------------

>9720_9720_12_BID-ATP6V1E1_BID_chr22_18220783_ENST00000551952_ATP6V1E1_chr22_18096086_ENST00000399798_length(amino acids)=411AA_BP=1
MKQSRKGSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRS
SHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALL
LAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLR
ARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPE

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:18095578/chr22:18226779)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BID P55957	ATP6V1E1 P36543
FUNCTION: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. {ECO:0000250\|UniProtKB:P70444, ECO:0000269\|PubMed:14583606}.	FUNCTION: Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BID

chr22:18220782

chr22:18096086

ENST00000317361

86_100

238.0

242.0

Motif

BH3

Hgene

BID

chr22:18220782

chr22:18096086

ENST00000342111

86_100

223.66666666666666

182.33333333333334

Motif

BH3

Hgene

BID

chr22:18220782

chr22:18096086

ENST00000399774

86_100

192.0

196.0

Motif

BH3

Hgene

BID

chr22:18220782

chr22:18096086

ENST00000551952

86_100

192.0

196.0

Motif

BH3

Hgene

BID

chr22:18220783

chr22:18096086

ENST00000317361

86_100

238.0

242.0

Motif

BH3

Hgene

BID

chr22:18220783

chr22:18096086

ENST00000342111

86_100

223.66666666666666

182.33333333333334

Motif

BH3

Hgene

BID

chr22:18220783

chr22:18096086

ENST00000399774

86_100

192.0

196.0

Motif

BH3

Hgene

BID

chr22:18220783

chr22:18096086

ENST00000551952

86_100

192.0

196.0

Motif

BH3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BID

chr22:18220782

chr22:18096086

ENST00000399765

86_100

96.0

100.0

Motif

BH3

Hgene

BID

chr22:18220782

chr22:18096086

ENST00000399767

86_100

96.0

100.0

Motif

BH3

Hgene

BID

chr22:18220783

chr22:18096086

ENST00000399765

86_100

96.0

100.0

Motif

BH3

Hgene

BID

chr22:18220783

chr22:18096086

ENST00000399767

86_100

96.0

100.0

Motif

BH3

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
BID
ATP6V1E1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to BID-ATP6V1E1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to BID-ATP6V1E1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source