UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:BIRC2-YAP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BIRC2-YAP1
FusionPDB ID: 9741
FusionGDB2.0 ID: 9741
HgeneTgene
Gene symbol

BIRC2

YAP1

Gene ID

329

10413

Gene namebaculoviral IAP repeat containing 2Yes1 associated transcriptional regulator
SynonymsAPI1|HIAP2|Hiap-2|MIHB|RNF48|c-IAP1|cIAP1COB1|YAP|YAP2|YAP65|YKI
Cytomap

11q22.2

11q22.1

Type of geneprotein-codingprotein-coding
Descriptionbaculoviral IAP repeat-containing protein 2IAP homolog BIAP-2NFR2-TRAF signalling complex proteinRING finger protein 48RING-type E3 ubiquitin transferase BIRC2TNFR2-TRAF-signaling complex protein 2apoptosis inhibitor 1cellular inhibitor of apoptostranscriptional coactivator YAP165 kDa Yes-associated proteinYes associated protein 1protein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog
Modification date2020032020200329
UniProtAcc

Q13490

.
Ensembl transtripts involved in fusion geneENST idsENST00000527910, ENST00000227758, 
ENST00000530675, ENST00000532672, 
ENST00000282441, ENST00000345877, 
ENST00000524575, ENST00000526343, 
ENST00000531439, ENST00000537274, 
ENST00000528834, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 5 X 3=6020 X 10 X 13=2600
# samples 421
** MAII scorelog2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2600*10)=-3.63005039024969
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: BIRC2 [Title/Abstract] AND YAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BIRC2(102221674)-YAP1(102033187), # samples:1
YAP1(102080295)-BIRC2(102248226), # samples:1
YAP1(101985125)-BIRC2(102233626), # samples:1
YAP1(102080295)-BIRC2(102248227), # samples:1
YAP1(102080295)-BIRC2(102248410), # samples:1
YAP1(101985125)-BIRC2(102233627), # samples:1
YAP1(101985124)-BIRC2(102233626), # samples:1
Anticipated loss of major functional domain due to fusion event.BIRC2-YAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BIRC2-YAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BIRC2-YAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BIRC2-YAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
YAP1-BIRC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
YAP1-BIRC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
YAP1-BIRC2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
YAP1-BIRC2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
YAP1-BIRC2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
YAP1-BIRC2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBIRC2

GO:0000209

protein polyubiquitination

11907583

HgeneBIRC2

GO:0043066

negative regulation of apoptotic process

21525013

HgeneBIRC2

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

11907583

HgeneBIRC2

GO:0051726

regulation of cell cycle

15665297

HgeneBIRC2

GO:1902523

positive regulation of protein K63-linked ubiquitination

21931591

HgeneBIRC2

GO:1902524

positive regulation of protein K48-linked ubiquitination

21931591

HgeneBIRC2

GO:1902527

positive regulation of protein monoubiquitination

21931591

TgeneYAP1

GO:0006974

cellular response to DNA damage stimulus

18280240

TgeneYAP1

GO:0008283

cell proliferation

17974916

TgeneYAP1

GO:0032570

response to progesterone

16772533

TgeneYAP1

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

16772533

TgeneYAP1

GO:0045893

positive regulation of transcription, DNA-templated

20368466

TgeneYAP1

GO:0045944

positive regulation of transcription by RNA polymerase II

25796446

TgeneYAP1

GO:0050767

regulation of neurogenesis

25433207

TgeneYAP1

GO:0050847

progesterone receptor signaling pathway

16772533

TgeneYAP1

GO:0060242

contact inhibition

17974916

TgeneYAP1

GO:0065003

protein-containing complex assembly

20368466

TgeneYAP1

GO:0071480

cellular response to gamma radiation

18280240

TgeneYAP1

GO:0072091

regulation of stem cell proliferation

25433207


check buttonFusion gene breakpoints across BIRC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across YAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-4443-01ABIRC2chr11

102221674

-YAP1chr11

102033187

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000530675BIRC2chr11102221674-ENST00000526343YAP1chr11102033187+244510121071792561
ENST00000530675BIRC2chr11102221674-ENST00000282441YAP1chr11102033187+543810121071954615
ENST00000530675BIRC2chr11102221674-ENST00000537274YAP1chr11102033187+540210121071918603
ENST00000530675BIRC2chr11102221674-ENST00000345877YAP1chr11102033187+528810121071804565
ENST00000530675BIRC2chr11102221674-ENST00000531439YAP1chr11102033187+193010121071906599
ENST00000530675BIRC2chr11102221674-ENST00000524575YAP1chr11102033187+216710121071954615
ENST00000227758BIRC2chr11102221674-ENST00000526343YAP1chr11102033187+3827239413993174591
ENST00000227758BIRC2chr11102221674-ENST00000282441YAP1chr11102033187+6820239413993336645
ENST00000227758BIRC2chr11102221674-ENST00000537274YAP1chr11102033187+6784239413993300633
ENST00000227758BIRC2chr11102221674-ENST00000345877YAP1chr11102033187+6670239413993186595
ENST00000227758BIRC2chr11102221674-ENST00000531439YAP1chr11102033187+3312239413993288629
ENST00000227758BIRC2chr11102221674-ENST00000524575YAP1chr11102033187+3549239413993336645
ENST00000532672BIRC2chr11102221674-ENST00000526343YAP1chr11102033187+270212693372049570
ENST00000532672BIRC2chr11102221674-ENST00000282441YAP1chr11102033187+569512693372211624
ENST00000532672BIRC2chr11102221674-ENST00000537274YAP1chr11102033187+565912693372175612
ENST00000532672BIRC2chr11102221674-ENST00000345877YAP1chr11102033187+554512693372061574
ENST00000532672BIRC2chr11102221674-ENST00000531439YAP1chr11102033187+218712693372163608
ENST00000532672BIRC2chr11102221674-ENST00000524575YAP1chr11102033187+242412693372211624

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000530675ENST00000526343BIRC2chr11102221674-YAP1chr11102033187+0.0081594740.9918405
ENST00000530675ENST00000282441BIRC2chr11102221674-YAP1chr11102033187+0.0004559090.9995441
ENST00000530675ENST00000537274BIRC2chr11102221674-YAP1chr11102033187+0.0004925770.9995074
ENST00000530675ENST00000345877BIRC2chr11102221674-YAP1chr11102033187+0.0003427920.99965715
ENST00000530675ENST00000531439BIRC2chr11102221674-YAP1chr11102033187+0.017106430.9828935
ENST00000530675ENST00000524575BIRC2chr11102221674-YAP1chr11102033187+0.015768990.98423105
ENST00000227758ENST00000526343BIRC2chr11102221674-YAP1chr11102033187+0.002252690.99774724
ENST00000227758ENST00000282441BIRC2chr11102221674-YAP1chr11102033187+0.0006351930.9993648
ENST00000227758ENST00000537274BIRC2chr11102221674-YAP1chr11102033187+0.0008386620.99916136
ENST00000227758ENST00000345877BIRC2chr11102221674-YAP1chr11102033187+0.0006110620.99938893
ENST00000227758ENST00000531439BIRC2chr11102221674-YAP1chr11102033187+0.0035946920.99640536
ENST00000227758ENST00000524575BIRC2chr11102221674-YAP1chr11102033187+0.0035609280.99643904
ENST00000532672ENST00000526343BIRC2chr11102221674-YAP1chr11102033187+0.0046119030.9953881
ENST00000532672ENST00000282441BIRC2chr11102221674-YAP1chr11102033187+0.0003753650.9996246
ENST00000532672ENST00000537274BIRC2chr11102221674-YAP1chr11102033187+0.0002817440.99971825
ENST00000532672ENST00000345877BIRC2chr11102221674-YAP1chr11102033187+0.0002420820.99975795
ENST00000532672ENST00000531439BIRC2chr11102221674-YAP1chr11102033187+0.010622110.9893779
ENST00000532672ENST00000524575BIRC2chr11102221674-YAP1chr11102033187+0.0101053010.9898947

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>9741_9741_1_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000227758_YAP1_chr11_102033187_ENST00000282441_length(amino acids)=645AA_BP=331
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLML
DNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYA
MSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHA
ARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPP
VQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQ
QLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTD
SGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESV

--------------------------------------------------------------

>9741_9741_2_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000227758_YAP1_chr11_102033187_ENST00000345877_length(amino acids)=595AA_BP=331
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLML
DNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYA
MSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHA
ARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPP
VQQNMMNSASAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQVRPQELALRSQLPTLEQDG
GTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIP

--------------------------------------------------------------

>9741_9741_3_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000227758_YAP1_chr11_102033187_ENST00000524575_length(amino acids)=645AA_BP=331
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLML
DNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYA
MSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHA
ARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPP
VQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQ
QLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTD
SGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESV

--------------------------------------------------------------

>9741_9741_4_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000227758_YAP1_chr11_102033187_ENST00000526343_length(amino acids)=591AA_BP=331
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLML
DNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYA
MSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHA
ARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPP
VQQNMMNSASAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQELALRSQLPTLEQDGGTQN
PVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNV

--------------------------------------------------------------

>9741_9741_5_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000227758_YAP1_chr11_102033187_ENST00000531439_length(amino acids)=629AA_BP=331
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLML
DNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYA
MSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHA
ARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPP
VQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQ
QLQMEKERLRLKQQELLRQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDD

--------------------------------------------------------------

>9741_9741_6_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000227758_YAP1_chr11_102033187_ENST00000537274_length(amino acids)=633AA_BP=331
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLML
DNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYA
MSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHA
ARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPP
VQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQ
QLQMEKERLRLKQQELLRQVRPQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPR
TPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFL

--------------------------------------------------------------

>9741_9741_7_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000530675_YAP1_chr11_102033187_ENST00000282441_length(amino acids)=615AA_BP=301
MRRPLGSRAASVFAAPALRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSAS
LGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFY
YIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGR
NDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYI
NHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTAN
SPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTI

--------------------------------------------------------------

>9741_9741_8_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000530675_YAP1_chr11_102033187_ENST00000345877_length(amino acids)=565AA_BP=301
MRRPLGSRAASVFAAPALRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSAS
LGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFY
YIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGR
NDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASAMNQRISQSAPVKQPPPLAP
QSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQVRPQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSG
TYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALS

--------------------------------------------------------------

>9741_9741_9_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000530675_YAP1_chr11_102033187_ENST00000524575_length(amino acids)=615AA_BP=301
MRRPLGSRAASVFAAPALRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSAS
LGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFY
YIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGR
NDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYI
NHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTAN
SPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTI

--------------------------------------------------------------

>9741_9741_10_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000530675_YAP1_chr11_102033187_ENST00000526343_length(amino acids)=561AA_BP=301
MRRPLGSRAASVFAAPALRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSAS
LGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFY
YIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGR
NDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASAMNQRISQSAPVKQPPPLAP
QSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHS
RDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDIL

--------------------------------------------------------------

>9741_9741_11_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000530675_YAP1_chr11_102033187_ENST00000531439_length(amino acids)=599AA_BP=301
MRRPLGSRAASVFAAPALRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSAS
LGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFY
YIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGR
NDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYI
NHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQELALRSQLPTL
EQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYL

--------------------------------------------------------------

>9741_9741_12_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000530675_YAP1_chr11_102033187_ENST00000537274_length(amino acids)=603AA_BP=301
MRRPLGSRAASVFAAPALRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSAS
LGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFY
YIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGR
NDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYI
NHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQVRPQELALRSQ
LPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRF

--------------------------------------------------------------

>9741_9741_13_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000532672_YAP1_chr11_102033187_ENST00000282441_length(amino acids)=624AA_BP=310
MEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCS
FIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSP
SELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLA
SAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAM
TQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAM
RNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV

--------------------------------------------------------------

>9741_9741_14_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000532672_YAP1_chr11_102033187_ENST00000345877_length(amino acids)=574AA_BP=310
MEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCS
FIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSP
SELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLA
SAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASAMNQRISQSAP
VKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQVRPQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTN
SSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEEL

--------------------------------------------------------------

>9741_9741_15_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000532672_YAP1_chr11_102033187_ENST00000524575_length(amino acids)=624AA_BP=310
MEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCS
FIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSP
SELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLA
SAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAM
TQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAM
RNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV

--------------------------------------------------------------

>9741_9741_16_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000532672_YAP1_chr11_102033187_ENST00000526343_length(amino acids)=570AA_BP=310
MEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCS
FIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSP
SELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLA
SAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASAMNQRISQSAP
VKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDP
FLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSL

--------------------------------------------------------------

>9741_9741_17_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000532672_YAP1_chr11_102033187_ENST00000531439_length(amino acids)=608AA_BP=310
MEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCS
FIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSP
SELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLA
SAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAM
TQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQEL
ALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPS

--------------------------------------------------------------

>9741_9741_18_BIRC2-YAP1_BIRC2_chr11_102221674_ENST00000532672_YAP1_chr11_102033187_ENST00000537274_length(amino acids)=612AA_BP=310
MEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCS
FIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSP
SELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLA
SAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPSHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAM
TQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQVR
PQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQS

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:102221674/chr11:102033187)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BIRC2

Q13490

.
FUNCTION: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. {ECO:0000269|PubMed:15665297, ECO:0000269|PubMed:18082613, ECO:0000269|PubMed:21145488, ECO:0000269|PubMed:21653699, ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBIRC2chr11:102221674chr11:102033187ENST00000227758-39184_250331.6666666666667619.0RepeatNote=BIR 2
HgeneBIRC2chr11:102221674chr11:102033187ENST00000227758-3946_113331.6666666666667619.0RepeatNote=BIR 1
HgeneBIRC2chr11:102221674chr11:102033187ENST00000530675-39184_250282.6666666666667570.0RepeatNote=BIR 2
HgeneBIRC2chr11:102221674chr11:102033187ENST00000530675-3946_113282.6666666666667570.0RepeatNote=BIR 1
TgeneYAP1chr11:102221674chr11:102033187ENST0000028244119298_359190.66666666666666505.0Coiled coilOntology_term=ECO:0000255
TgeneYAP1chr11:102221674chr11:102033187ENST0000034587717298_359190.66666666666666455.0Coiled coilOntology_term=ECO:0000255
TgeneYAP1chr11:102221674chr11:102033187ENST0000052457519298_35912.666666666666666327.0Coiled coilOntology_term=ECO:0000255
TgeneYAP1chr11:102221674chr11:102033187ENST000005245751986_10012.666666666666666327.0Coiled coilOntology_term=ECO:0000269
TgeneYAP1chr11:102221674chr11:102033187ENST0000052634317298_359190.66666666666666451.0Coiled coilOntology_term=ECO:0000255
TgeneYAP1chr11:102221674chr11:102033187ENST0000053143918298_359190.66666666666666489.0Coiled coilOntology_term=ECO:0000255
TgeneYAP1chr11:102221674chr11:102033187ENST0000053727418298_359190.66666666666666493.0Coiled coilOntology_term=ECO:0000255
TgeneYAP1chr11:102221674chr11:102033187ENST0000028244119230_263190.66666666666666505.0DomainWW 2
TgeneYAP1chr11:102221674chr11:102033187ENST0000034587717230_263190.66666666666666455.0DomainWW 2
TgeneYAP1chr11:102221674chr11:102033187ENST0000052457519171_20412.666666666666666327.0DomainWW 1
TgeneYAP1chr11:102221674chr11:102033187ENST0000052457519230_26312.666666666666666327.0DomainWW 2
TgeneYAP1chr11:102221674chr11:102033187ENST0000052634317230_263190.66666666666666451.0DomainWW 2
TgeneYAP1chr11:102221674chr11:102033187ENST0000053143918230_263190.66666666666666489.0DomainWW 2
TgeneYAP1chr11:102221674chr11:102033187ENST0000053727418230_263190.66666666666666493.0DomainWW 2
TgeneYAP1chr11:102221674chr11:102033187ENST0000028244119291_504190.66666666666666505.0RegionNote=Transactivation domain
TgeneYAP1chr11:102221674chr11:102033187ENST0000034587717291_504190.66666666666666455.0RegionNote=Transactivation domain
TgeneYAP1chr11:102221674chr11:102033187ENST0000052457519291_50412.666666666666666327.0RegionNote=Transactivation domain
TgeneYAP1chr11:102221674chr11:102033187ENST0000052634317291_504190.66666666666666451.0RegionNote=Transactivation domain
TgeneYAP1chr11:102221674chr11:102033187ENST0000053143918291_504190.66666666666666489.0RegionNote=Transactivation domain
TgeneYAP1chr11:102221674chr11:102033187ENST0000053727418291_504190.66666666666666493.0RegionNote=Transactivation domain

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBIRC2chr11:102221674chr11:102033187ENST00000227758-39453_543331.6666666666667619.0DomainCARD
HgeneBIRC2chr11:102221674chr11:102033187ENST00000530675-39453_543282.6666666666667570.0DomainCARD
HgeneBIRC2chr11:102221674chr11:102033187ENST00000227758-39269_336331.6666666666667619.0RepeatNote=BIR 3
HgeneBIRC2chr11:102221674chr11:102033187ENST00000530675-39269_336282.6666666666667570.0RepeatNote=BIR 3
HgeneBIRC2chr11:102221674chr11:102033187ENST00000227758-39571_606331.6666666666667619.0Zinc fingerRING-type
HgeneBIRC2chr11:102221674chr11:102033187ENST00000530675-39571_606282.6666666666667570.0Zinc fingerRING-type
TgeneYAP1chr11:102221674chr11:102033187ENST000002824411986_100190.66666666666666505.0Coiled coilOntology_term=ECO:0000269
TgeneYAP1chr11:102221674chr11:102033187ENST000003458771786_100190.66666666666666455.0Coiled coilOntology_term=ECO:0000269
TgeneYAP1chr11:102221674chr11:102033187ENST000005263431786_100190.66666666666666451.0Coiled coilOntology_term=ECO:0000269
TgeneYAP1chr11:102221674chr11:102033187ENST000005314391886_100190.66666666666666489.0Coiled coilOntology_term=ECO:0000269
TgeneYAP1chr11:102221674chr11:102033187ENST000005372741886_100190.66666666666666493.0Coiled coilOntology_term=ECO:0000269
TgeneYAP1chr11:102221674chr11:102033187ENST00000282441193_49190.66666666666666505.0Compositional biasNote=Pro-rich
TgeneYAP1chr11:102221674chr11:102033187ENST00000345877173_49190.66666666666666455.0Compositional biasNote=Pro-rich
TgeneYAP1chr11:102221674chr11:102033187ENST00000524575193_4912.666666666666666327.0Compositional biasNote=Pro-rich
TgeneYAP1chr11:102221674chr11:102033187ENST00000526343173_49190.66666666666666451.0Compositional biasNote=Pro-rich
TgeneYAP1chr11:102221674chr11:102033187ENST00000531439183_49190.66666666666666489.0Compositional biasNote=Pro-rich
TgeneYAP1chr11:102221674chr11:102033187ENST00000537274183_49190.66666666666666493.0Compositional biasNote=Pro-rich
TgeneYAP1chr11:102221674chr11:102033187ENST0000028244119171_204190.66666666666666505.0DomainWW 1
TgeneYAP1chr11:102221674chr11:102033187ENST0000034587717171_204190.66666666666666455.0DomainWW 1
TgeneYAP1chr11:102221674chr11:102033187ENST0000052634317171_204190.66666666666666451.0DomainWW 1
TgeneYAP1chr11:102221674chr11:102033187ENST0000053143918171_204190.66666666666666489.0DomainWW 1
TgeneYAP1chr11:102221674chr11:102033187ENST0000053727418171_204190.66666666666666493.0DomainWW 1


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
BIRC2
YAP1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to BIRC2-YAP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to BIRC2-YAP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource