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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:USP36-DNAH17

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: USP36-DNAH17
	FusionPDB ID: 97429
	FusionGDB2.0 ID: 97429
		Hgene	Tgene
	Gene symbol	USP36	DNAH17
	Gene ID	57602	8632
	Gene name	ubiquitin specific peptidase 36	dynein axonemal heavy chain 17
	Synonyms	DUB1	DNAHL1\|DNEL2\|SPGF39
	Cytomap	17q25.3	17q25.3
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin carboxyl-terminal hydrolase 36deubiquitinating enzyme 36ubiquitin specific protease 36ubiquitin thioesterase 36ubiquitin-specific-processing protease 36	dynein heavy chain 17, axonemalaxonemal beta dynein heavy chain 17axonemal dynein heavy chain-like protein 1ciliary dynein heavy chain 17ciliary dynein heavy chain-like protein 1dynein light chain 2, axonemaldynein, axonemal, heavy polypeptide 17
	Modification date	20200313	20200320
	UniProtAcc	.	Q9UFH2
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000312010, ENST00000449938, ENST00000542802, ENST00000588467, ENST00000589424, ENST00000590546,	ENST00000586052, ENST00000389840, ENST00000585328,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 7 X 4=140	15 X 16 X 11=2640
	# samples	7	19
	** MAII score	log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/2640*10)=-3.79646660591487 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: USP36 [Title/Abstract] AND DNAH17 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	USP36(76808942)-DNAH17(76433950), # samples:2 USP36(76808941)-DNAH17(76433950), # samples:2
Anticipated loss of major functional domain due to fusion event.	USP36-DNAH17 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. USP36-DNAH17 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. USP36-DNAH17 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. USP36-DNAH17 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. USP36-DNAH17 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. USP36-DNAH17 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	USP36	GO:0007000	nucleolus organization	19208757
Hgene	USP36	GO:0016579	protein deubiquitination	14715245\|19208757\|25775507
Hgene	USP36	GO:2000232	regulation of rRNA processing	19208757

Fusion gene breakpoints across USP36 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DNAH17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-V5-AASV-01A	USP36	chr17	76808942	-	DNAH17	chr17	76433950	-
ChimerDB4	ESCA	TCGA-V5-AASV	USP36	chr17	76808941	-	DNAH17	chr17	76433950	-
ChimerDB4	ESCA	TCGA-V5-AASV	USP36	chr17	76808942	-	DNAH17	chr17	76433950	-
ChimerDB4	ESCA	TCGA-V5-AASV	USP36	chr17	76808942	-	DNAH17	chr17	76433962	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000542802	USP36	chr17	76808942	-	ENST00000389840	DNAH17	chr17	76433950	-	3731	1851	444	3521	1025
ENST00000542802	USP36	chr17	76808942	-	ENST00000585328	DNAH17	chr17	76433950	-	3644	1851	444	3434	996
ENST00000449938	USP36	chr17	76808942	-	ENST00000389840	DNAH17	chr17	76433950	-	3843	1963	1204	3633	809
ENST00000449938	USP36	chr17	76808942	-	ENST00000585328	DNAH17	chr17	76433950	-	3756	1963	1204	3546	780
ENST00000542802	USP36	chr17	76808941	-	ENST00000389840	DNAH17	chr17	76433950	-	3731	1851	444	3521	1025
ENST00000542802	USP36	chr17	76808941	-	ENST00000585328	DNAH17	chr17	76433950	-	3644	1851	444	3434	996
ENST00000449938	USP36	chr17	76808941	-	ENST00000389840	DNAH17	chr17	76433950	-	3843	1963	1204	3633	809
ENST00000449938	USP36	chr17	76808941	-	ENST00000585328	DNAH17	chr17	76433950	-	3756	1963	1204	3546	780

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000542802	ENST00000389840	USP36	chr17	76808942	-	DNAH17	chr17	76433950	-	0.001978512	0.9980215
ENST00000542802	ENST00000585328	USP36	chr17	76808942	-	DNAH17	chr17	76433950	-	0.001781503	0.9982185
ENST00000449938	ENST00000389840	USP36	chr17	76808942	-	DNAH17	chr17	76433950	-	0.002234086	0.9977659
ENST00000449938	ENST00000585328	USP36	chr17	76808942	-	DNAH17	chr17	76433950	-	0.002625756	0.9973743
ENST00000542802	ENST00000389840	USP36	chr17	76808941	-	DNAH17	chr17	76433950	-	0.001978512	0.9980215
ENST00000542802	ENST00000585328	USP36	chr17	76808941	-	DNAH17	chr17	76433950	-	0.001781503	0.9982185
ENST00000449938	ENST00000389840	USP36	chr17	76808941	-	DNAH17	chr17	76433950	-	0.002234086	0.9977659
ENST00000449938	ENST00000585328	USP36	chr17	76808941	-	DNAH17	chr17	76433950	-	0.002625756	0.9973743

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>97429_97429_1_USP36-DNAH17_USP36_chr17_76808941_ENST00000449938_DNAH17_chr17_76433950_ENST00000389840_length(amino acids)=809AA_BP=1
MLSPSLKGWGLLFRLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAYMCAKCK
KKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQ
MNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIPDHSKKNIGNGIISSPLTGKNIHLVARWLGTLDKKLE
HYSTGSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKALDLFTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRK
FGAQGWNRSYPFNNGDLTISINVLYNYLEANPKVPWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTEMLEGDVLLAPGFQIPPNL
DYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSGAGTGVSREEKAGSLKLLPSERKGEDLELRRGGCPGT
GFQVKAVLDDILEKIPETFNMAEIMAKAAEKTPYVVVAFQECERMNILTNEMRRSLKELNLGLKGELTITTDVEDLSTALFYDTVPDTWV
ARAYPSMMGLAAWYADLLLRIRELEAWTTDFALPTTVWLAGFFNPQSFLTAIMQSMARKNEWPLDKMCLSVEVTKKNREDMTAPPREGSY

--------------------------------------------------------------

>97429_97429_2_USP36-DNAH17_USP36_chr17_76808941_ENST00000449938_DNAH17_chr17_76433950_ENST00000585328_length(amino acids)=780AA_BP=1
MLSPSLKGWGLLFRLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAYMCAKCK
KKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQ
MNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIPDHSKKNIGNGIISSPLTGKNIHLVARWLGTLDKKLE
HYSTGSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKALDLFTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRK
FGAQGWNRSYPFNNGDLTISINVLYNYLEANPKVPWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTEMLEGDVLLAPGFQIPPNL
DYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSGAGTGVSREEKVKAVLDDILEKIPETFNMAEIMAKAA
EKTPYVVVAFQECERMNILTNEMRRSLKELNLGLKGELTITTDVEDLSTALFYDTVPDTWVARAYPSMMGLAAWYADLLLRIRELEAWTT
DFALPTTVWLAGFFNPQSFLTAIMQSMARKNEWPLDKMCLSVEVTKKNREDMTAPPREGSYVYGLFMEGARWDTQTGVIAEARLKELTPA

--------------------------------------------------------------

>97429_97429_3_USP36-DNAH17_USP36_chr17_76808941_ENST00000542802_DNAH17_chr17_76433950_ENST00000389840_length(amino acids)=1025AA_BP=0
MPIVDKLKEALKPGRKDSADDGELGKLLASSAKKVLLQKIEFEPASKSFSYQLEALKSKYVLLNPKTEGASRHKSGDDPPARRQGSEHTY
ESCGDGVPAPQKVLFPTERLSLRWERVFRVGAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFAN
SGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLD
VALEIRQAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNG
DPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIP
DHSKKNIGNGIISSPLTGKNIHLVARWLGTLDKKLEHYSTGSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKAL
DLFTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTISINVLYNYLEANPKVPWDDLRYLFGEIMYGGHITD
DWDRRLCRTYLAEYIRTEMLEGDVLLAPGFQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSG
AGTGVSREEKAGSLKLLPSERKGEDLELRRGGCPGTGFQVKAVLDDILEKIPETFNMAEIMAKAAEKTPYVVVAFQECERMNILTNEMRR
SLKELNLGLKGELTITTDVEDLSTALFYDTVPDTWVARAYPSMMGLAAWYADLLLRIRELEAWTTDFALPTTVWLAGFFNPQSFLTAIMQ
SMARKNEWPLDKMCLSVEVTKKNREDMTAPPREGSYVYGLFMEGARWDTQTGVIAEARLKELTPAMPVIFIKAIPVDRMETKNIYECPVY

--------------------------------------------------------------

>97429_97429_4_USP36-DNAH17_USP36_chr17_76808941_ENST00000542802_DNAH17_chr17_76433950_ENST00000585328_length(amino acids)=996AA_BP=0
MPIVDKLKEALKPGRKDSADDGELGKLLASSAKKVLLQKIEFEPASKSFSYQLEALKSKYVLLNPKTEGASRHKSGDDPPARRQGSEHTY
ESCGDGVPAPQKVLFPTERLSLRWERVFRVGAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFAN
SGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLD
VALEIRQAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNG
DPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIP
DHSKKNIGNGIISSPLTGKNIHLVARWLGTLDKKLEHYSTGSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKAL
DLFTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTISINVLYNYLEANPKVPWDDLRYLFGEIMYGGHITD
DWDRRLCRTYLAEYIRTEMLEGDVLLAPGFQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSG
AGTGVSREEKVKAVLDDILEKIPETFNMAEIMAKAAEKTPYVVVAFQECERMNILTNEMRRSLKELNLGLKGELTITTDVEDLSTALFYD
TVPDTWVARAYPSMMGLAAWYADLLLRIRELEAWTTDFALPTTVWLAGFFNPQSFLTAIMQSMARKNEWPLDKMCLSVEVTKKNREDMTA
PPREGSYVYGLFMEGARWDTQTGVIAEARLKELTPAMPVIFIKAIPVDRMETKNIYECPVYKTRIRGPTYVWTFNLKTKEKAAKWILAAV

--------------------------------------------------------------

>97429_97429_5_USP36-DNAH17_USP36_chr17_76808942_ENST00000449938_DNAH17_chr17_76433950_ENST00000389840_length(amino acids)=809AA_BP=1
MLSPSLKGWGLLFRLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAYMCAKCK
KKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQ
MNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIPDHSKKNIGNGIISSPLTGKNIHLVARWLGTLDKKLE
HYSTGSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKALDLFTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRK
FGAQGWNRSYPFNNGDLTISINVLYNYLEANPKVPWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTEMLEGDVLLAPGFQIPPNL
DYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSGAGTGVSREEKAGSLKLLPSERKGEDLELRRGGCPGT
GFQVKAVLDDILEKIPETFNMAEIMAKAAEKTPYVVVAFQECERMNILTNEMRRSLKELNLGLKGELTITTDVEDLSTALFYDTVPDTWV
ARAYPSMMGLAAWYADLLLRIRELEAWTTDFALPTTVWLAGFFNPQSFLTAIMQSMARKNEWPLDKMCLSVEVTKKNREDMTAPPREGSY

--------------------------------------------------------------

>97429_97429_6_USP36-DNAH17_USP36_chr17_76808942_ENST00000449938_DNAH17_chr17_76433950_ENST00000585328_length(amino acids)=780AA_BP=1
MLSPSLKGWGLLFRLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAYMCAKCK
KKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQ
MNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIPDHSKKNIGNGIISSPLTGKNIHLVARWLGTLDKKLE
HYSTGSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKALDLFTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRK
FGAQGWNRSYPFNNGDLTISINVLYNYLEANPKVPWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTEMLEGDVLLAPGFQIPPNL
DYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSGAGTGVSREEKVKAVLDDILEKIPETFNMAEIMAKAA
EKTPYVVVAFQECERMNILTNEMRRSLKELNLGLKGELTITTDVEDLSTALFYDTVPDTWVARAYPSMMGLAAWYADLLLRIRELEAWTT
DFALPTTVWLAGFFNPQSFLTAIMQSMARKNEWPLDKMCLSVEVTKKNREDMTAPPREGSYVYGLFMEGARWDTQTGVIAEARLKELTPA

--------------------------------------------------------------

>97429_97429_7_USP36-DNAH17_USP36_chr17_76808942_ENST00000542802_DNAH17_chr17_76433950_ENST00000389840_length(amino acids)=1025AA_BP=0
MPIVDKLKEALKPGRKDSADDGELGKLLASSAKKVLLQKIEFEPASKSFSYQLEALKSKYVLLNPKTEGASRHKSGDDPPARRQGSEHTY
ESCGDGVPAPQKVLFPTERLSLRWERVFRVGAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFAN
SGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLD
VALEIRQAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNG
DPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIP
DHSKKNIGNGIISSPLTGKNIHLVARWLGTLDKKLEHYSTGSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKAL
DLFTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTISINVLYNYLEANPKVPWDDLRYLFGEIMYGGHITD
DWDRRLCRTYLAEYIRTEMLEGDVLLAPGFQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSG
AGTGVSREEKAGSLKLLPSERKGEDLELRRGGCPGTGFQVKAVLDDILEKIPETFNMAEIMAKAAEKTPYVVVAFQECERMNILTNEMRR
SLKELNLGLKGELTITTDVEDLSTALFYDTVPDTWVARAYPSMMGLAAWYADLLLRIRELEAWTTDFALPTTVWLAGFFNPQSFLTAIMQ
SMARKNEWPLDKMCLSVEVTKKNREDMTAPPREGSYVYGLFMEGARWDTQTGVIAEARLKELTPAMPVIFIKAIPVDRMETKNIYECPVY

--------------------------------------------------------------

>97429_97429_8_USP36-DNAH17_USP36_chr17_76808942_ENST00000542802_DNAH17_chr17_76433950_ENST00000585328_length(amino acids)=996AA_BP=0
MPIVDKLKEALKPGRKDSADDGELGKLLASSAKKVLLQKIEFEPASKSFSYQLEALKSKYVLLNPKTEGASRHKSGDDPPARRQGSEHTY
ESCGDGVPAPQKVLFPTERLSLRWERVFRVGAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFAN
SGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLD
VALEIRQAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNG
DPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIP
DHSKKNIGNGIISSPLTGKNIHLVARWLGTLDKKLEHYSTGSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKAL
DLFTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTISINVLYNYLEANPKVPWDDLRYLFGEIMYGGHITD
DWDRRLCRTYLAEYIRTEMLEGDVLLAPGFQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSG
AGTGVSREEKVKAVLDDILEKIPETFNMAEIMAKAAEKTPYVVVAFQECERMNILTNEMRRSLKELNLGLKGELTITTDVEDLSTALFYD
TVPDTWVARAYPSMMGLAAWYADLLLRIRELEAWTTDFALPTTVWLAGFFNPQSFLTAIMQSMARKNEWPLDKMCLSVEVTKKNREDMTA
PPREGSYVYGLFMEGARWDTQTGVIAEARLKELTPAMPVIFIKAIPVDRMETKNIYECPVYKTRIRGPTYVWTFNLKTKEKAAKWILAAV

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:76808942/chr17:76433950)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DNAH17 Q9UFH2
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (Probable). Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating (PubMed:31178125). {ECO:0000269\|PubMed:31178125, ECO:0000305\|PubMed:31178125}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

USP36

chr17:76808941

chr17:76433950

ENST00000312010

122_423

469.0

1124.0

Domain

Note=USP

Hgene

USP36

chr17:76808941

chr17:76433950

ENST00000542802

122_423

469.0

1772.0

Domain

Note=USP

Hgene

USP36

chr17:76808942

chr17:76433950

ENST00000312010

122_423

469.0

1124.0

Domain

Note=USP

Hgene

USP36

chr17:76808942

chr17:76433950

ENST00000542802

122_423

469.0

1772.0

Domain

Note=USP

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

4147_4182

3929.0

4486.0

Repeat

Note=TPR 3

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

4147_4182

3929.0

4486.0

Repeat

Note=TPR 3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

3027_3086

3929.0

4486.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

3257_3309

3929.0

4486.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

3027_3086

3929.0

4486.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

3257_3309

3929.0

4486.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

1847_1854

3929.0

4486.0

Nucleotide binding

ATP

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

2128_2135

3929.0

4486.0

Nucleotide binding

ATP

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

2455_2462

3929.0

4486.0

Nucleotide binding

ATP

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

2801_2808

3929.0

4486.0

Nucleotide binding

ATP

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

1847_1854

3929.0

4486.0

Nucleotide binding

ATP

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

2128_2135

3929.0

4486.0

Nucleotide binding

ATP

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

2455_2462

3929.0

4486.0

Nucleotide binding

ATP

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

2801_2808

3929.0

4486.0

Nucleotide binding

ATP

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

1809_2030

3929.0

4486.0

Region

AAA 1

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

1_1808

3929.0

4486.0

Region

Stem

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

2090_2311

3929.0

4486.0

Region

AAA 2

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

2417_2665

3929.0

4486.0

Region

AAA 3

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

2763_3012

3929.0

4486.0

Region

AAA 4

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

3027_3313

3929.0

4486.0

Region

Stalk

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

3405_3632

3929.0

4486.0

Region

AAA 5

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

3842_4068

3929.0

4486.0

Region

AAA 6

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

1809_2030

3929.0

4486.0

Region

AAA 1

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

1_1808

3929.0

4486.0

Region

Stem

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

2090_2311

3929.0

4486.0

Region

AAA 2

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

2417_2665

3929.0

4486.0

Region

AAA 3

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

2763_3012

3929.0

4486.0

Region

AAA 4

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

3027_3313

3929.0

4486.0

Region

Stalk

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

3405_3632

3929.0

4486.0

Region

AAA 5

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

3842_4068

3929.0

4486.0

Region

AAA 6

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

1019_1052

3929.0

4486.0

Repeat

Note=TPR 1

Tgene

DNAH17

chr17:76808941

chr17:76433950

ENST00000389840

1702_1736

3929.0

4486.0

Repeat

Note=TPR 2

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

1019_1052

3929.0

4486.0

Repeat

Note=TPR 1

Tgene

DNAH17

chr17:76808942

chr17:76433950

ENST00000389840

1702_1736

3929.0

4486.0

Repeat

Note=TPR 2

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1807_USP36_76808942_DNAH17_76433950_ranked_0.pdb	USP36	76808941	76808942	ENST00000585328	DNAH17	chr17	76433950	-	MPIVDKLKEALKPGRKDSADDGELGKLLASSAKKVLLQKIEFEPASKSFSYQLEALKSKYVLLNPKTEGASRHKSGDDPPARRQGSEHTY ESCGDGVPAPQKVLFPTERLSLRWERVFRVGAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFAN SGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLD VALEIRQAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNG DPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIP DHSKKNIGNGIISSPLTGKNIHLVARWLGTLDKKLEHYSTGSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKAL DLFTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTISINVLYNYLEANPKVPWDDLRYLFGEIMYGGHITD DWDRRLCRTYLAEYIRTEMLEGDVLLAPGFQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSG AGTGVSREEKAGSLKLLPSERKGEDLELRRGGCPGTGFQVKAVLDDILEKIPETFNMAEIMAKAAEKTPYVVVAFQECERMNILTNEMRR SLKELNLGLKGELTITTDVEDLSTALFYDTVPDTWVARAYPSMMGLAAWYADLLLRIRELEAWTTDFALPTTVWLAGFFNPQSFLTAIMQ SMARKNEWPLDKMCLSVEVTKKNREDMTAPPREGSYVYGLFMEGARWDTQTGVIAEARLKELTPAMPVIFIKAIPVDRMETKNIYECPVY	1025

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

USP36_pLDDT.png

DNAH17_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
USP36
DNAH17

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to USP36-DNAH17

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to USP36-DNAH17

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source