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Fusion Protein:BIRC3-MALT1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: BIRC3-MALT1 | FusionPDB ID: 9744 | FusionGDB2.0 ID: 9744 | Hgene | Tgene | Gene symbol | BIRC3 | MALT1 | Gene ID | 330 | 10892 |
| Gene name | baculoviral IAP repeat containing 3 | MALT1 paracaspase | |
| Synonyms | AIP1|API2|CIAP2|HAIP1|HIAP1|IAP-1|MALT2|MIHC|RNF49|c-IAP2 | IMD12|MLT|MLT1|PCASP1 | |
| Cytomap | 11q22.2 | 18q21.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | baculoviral IAP repeat-containing protein 3IAP homolog CRING finger protein 49RING-type E3 ubiquitin transferase BIRC3TNFR2-TRAF signaling complex proteinTNFR2-TRAF-signaling complex protein 1apoptosis inhibitor 2cellular inhibitor of apoptosis 2i | mucosa-associated lymphoid tissue lymphoma translocation protein 1MALT1 proteasecaspase-like proteinmucosa associated lymphoid tissue lymphoma translocation gene 1paracaspase-1 | |
| Modification date | 20200313 | 20200315 | |
| UniProtAcc | Q13489 | Q9UDY8 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000263464, ENST00000532808, ENST00000526421, | ENST00000345724, ENST00000348428, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 2 X 3 X 3=18 | 4 X 6 X 4=96 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: BIRC3 [Title/Abstract] AND MALT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | BIRC3(102201973)-MALT1(56363598), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | BIRC3-MALT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BIRC3-MALT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BIRC3-MALT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BIRC3-MALT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BIRC3 | GO:0031398 | positive regulation of protein ubiquitination | 21931591 |
| Tgene | MALT1 | GO:0006508 | proteolysis | 18223652 |
| Tgene | MALT1 | GO:0042981 | regulation of apoptotic process | 12819136 |
| Tgene | MALT1 | GO:0050852 | T cell receptor signaling pathway | 15125833 |
| Tgene | MALT1 | GO:0051168 | nuclear export | 16123224 |
| Fusion gene breakpoints across BIRC3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MALT1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerKB3 | . | . | BIRC3 | chr11 | 102201972 | + | MALT1 | chr18 | 56363597 | + |
| ChimerKB4 | . | . | BIRC3 | chr11 | 102201972 | + | MALT1 | chr18 | 56363597 | |
| ChimerKB4 | . | . | BIRC3 | chr11 | 102201972 | + | MALT1 | chr18 | 56363597 | + |
| ChiTaRS5.0 | N/A | AF123094 | BIRC3 | chr11 | 102201973 | + | MALT1 | chr18 | 56363598 | + |
| ChiTaRS5.0 | N/A | AX055871 | BIRC3 | chr11 | 102201973 | + | MALT1 | chr18 | 56363598 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000263464 | BIRC3 | chr11 | 102201972 | + | ENST00000348428 | MALT1 | chr18 | 56363597 | + | 8470 | 4074 | 2750 | 6172 | 1140 |
| ENST00000263464 | BIRC3 | chr11 | 102201972 | + | ENST00000345724 | MALT1 | chr18 | 56363597 | + | 6452 | 4074 | 2750 | 6139 | 1129 |
| ENST00000532808 | BIRC3 | chr11 | 102201972 | + | ENST00000348428 | MALT1 | chr18 | 56363597 | + | 5842 | 1446 | 122 | 3544 | 1140 |
| ENST00000532808 | BIRC3 | chr11 | 102201972 | + | ENST00000345724 | MALT1 | chr18 | 56363597 | + | 3824 | 1446 | 122 | 3511 | 1129 |
| ENST00000263464 | BIRC3 | chr11 | 102201973 | + | ENST00000348428 | MALT1 | chr18 | 56363598 | + | 8470 | 4074 | 2750 | 6172 | 1140 |
| ENST00000263464 | BIRC3 | chr11 | 102201973 | + | ENST00000345724 | MALT1 | chr18 | 56363598 | + | 6452 | 4074 | 2750 | 6139 | 1129 |
| ENST00000532808 | BIRC3 | chr11 | 102201973 | + | ENST00000348428 | MALT1 | chr18 | 56363598 | + | 5842 | 1446 | 122 | 3544 | 1140 |
| ENST00000532808 | BIRC3 | chr11 | 102201973 | + | ENST00000345724 | MALT1 | chr18 | 56363598 | + | 3824 | 1446 | 122 | 3511 | 1129 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000263464 | ENST00000348428 | BIRC3 | chr11 | 102201973 | + | MALT1 | chr18 | 56363598 | + | 0.002780849 | 0.9972192 |
| ENST00000263464 | ENST00000345724 | BIRC3 | chr11 | 102201973 | + | MALT1 | chr18 | 56363598 | + | 0.004667716 | 0.9953323 |
| ENST00000532808 | ENST00000348428 | BIRC3 | chr11 | 102201973 | + | MALT1 | chr18 | 56363598 | + | 0.000202308 | 0.99979776 |
| ENST00000532808 | ENST00000345724 | BIRC3 | chr11 | 102201973 | + | MALT1 | chr18 | 56363598 | + | 0.000354844 | 0.9996451 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >9744_9744_1_BIRC3-MALT1_BIRC3_chr11_102201972_ENST00000263464_MALT1_chr18_56363597_ENST00000345724_length(amino acids)=1129AA_BP=442 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLY PSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWP LTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVL VNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESRIKITVNPE SKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSE SKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNL GHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGH GYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSG LANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFD CGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFT VCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPAD -------------------------------------------------------------- >9744_9744_2_BIRC3-MALT1_BIRC3_chr11_102201972_ENST00000263464_MALT1_chr18_56363597_ENST00000348428_length(amino acids)=1140AA_BP=442 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLY PSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWP LTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVL VNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESRIKITVNPE SKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSE SKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEA VECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDK GVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQ GAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAH ELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSS LQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSH -------------------------------------------------------------- >9744_9744_3_BIRC3-MALT1_BIRC3_chr11_102201972_ENST00000532808_MALT1_chr18_56363597_ENST00000345724_length(amino acids)=1129AA_BP=442 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLY PSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWP LTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVL VNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESRIKITVNPE SKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSE SKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNL GHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGH GYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSG LANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFD CGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFT VCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPAD -------------------------------------------------------------- >9744_9744_4_BIRC3-MALT1_BIRC3_chr11_102201972_ENST00000532808_MALT1_chr18_56363597_ENST00000348428_length(amino acids)=1140AA_BP=442 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLY PSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWP LTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVL VNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESRIKITVNPE SKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSE SKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEA VECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDK GVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQ GAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAH ELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSS LQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSH -------------------------------------------------------------- >9744_9744_5_BIRC3-MALT1_BIRC3_chr11_102201973_ENST00000263464_MALT1_chr18_56363598_ENST00000345724_length(amino acids)=1129AA_BP=442 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLY PSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWP LTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVL VNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESRIKITVNPE SKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSE SKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNL GHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGH GYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSG LANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFD CGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFT VCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPAD -------------------------------------------------------------- >9744_9744_6_BIRC3-MALT1_BIRC3_chr11_102201973_ENST00000263464_MALT1_chr18_56363598_ENST00000348428_length(amino acids)=1140AA_BP=442 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLY PSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWP LTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVL VNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESRIKITVNPE SKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSE SKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEA VECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDK GVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQ GAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAH ELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSS LQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSH -------------------------------------------------------------- >9744_9744_7_BIRC3-MALT1_BIRC3_chr11_102201973_ENST00000532808_MALT1_chr18_56363598_ENST00000345724_length(amino acids)=1129AA_BP=442 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLY PSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWP LTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVL VNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESRIKITVNPE SKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSE SKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNL GHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGH GYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSG LANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFD CGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFT VCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPAD -------------------------------------------------------------- >9744_9744_8_BIRC3-MALT1_BIRC3_chr11_102201973_ENST00000532808_MALT1_chr18_56363598_ENST00000348428_length(amino acids)=1140AA_BP=442 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLY PSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWP LTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVL VNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESRIKITVNPE SKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSE SKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEA VECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDK GVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQ GAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAH ELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSS LQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSH -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:102201973/chr18:56363598) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BIRC3 | MALT1 |
| FUNCTION: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. {ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969}. | FUNCTION: Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475). {ECO:0000250|UniProtKB:Q2TBA3, ECO:0000269|PubMed:11262391, ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:31133753}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BIRC3 | chr11:102201973 | chr18:56363598 | ENST00000263464 | + | 6 | 9 | 169_235 | 441.3333333333333 | 605.0 | Repeat | Note=BIR 2 |
| Hgene | BIRC3 | chr11:102201973 | chr18:56363598 | ENST00000263464 | + | 6 | 9 | 255_322 | 441.3333333333333 | 605.0 | Repeat | Note=BIR 3 |
| Hgene | BIRC3 | chr11:102201973 | chr18:56363598 | ENST00000263464 | + | 6 | 9 | 29_96 | 441.3333333333333 | 605.0 | Repeat | Note=BIR 1 |
| Hgene | BIRC3 | chr11:102201973 | chr18:56363598 | ENST00000532808 | + | 7 | 10 | 169_235 | 441.3333333333333 | 605.0 | Repeat | Note=BIR 2 |
| Hgene | BIRC3 | chr11:102201973 | chr18:56363598 | ENST00000532808 | + | 7 | 10 | 255_322 | 441.3333333333333 | 605.0 | Repeat | Note=BIR 3 |
| Hgene | BIRC3 | chr11:102201973 | chr18:56363598 | ENST00000532808 | + | 7 | 10 | 29_96 | 441.3333333333333 | 605.0 | Repeat | Note=BIR 1 |
| Tgene | MALT1 | chr11:102201973 | chr18:56363598 | ENST00000345724 | 1 | 16 | 125_201 | 125.33333333333333 | 814.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | MALT1 | chr11:102201973 | chr18:56363598 | ENST00000345724 | 1 | 16 | 212_305 | 125.33333333333333 | 814.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | MALT1 | chr11:102201973 | chr18:56363598 | ENST00000348428 | 1 | 17 | 125_201 | 125.33333333333333 | 825.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | MALT1 | chr11:102201973 | chr18:56363598 | ENST00000348428 | 1 | 17 | 212_305 | 125.33333333333333 | 825.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | MALT1 | chr11:102201973 | chr18:56363598 | ENST00000345724 | 1 | 16 | 369_376 | 125.33333333333333 | 814.0 | Motif | Note=Nuclear export signal | |
| Tgene | MALT1 | chr11:102201973 | chr18:56363598 | ENST00000348428 | 1 | 17 | 369_376 | 125.33333333333333 | 825.0 | Motif | Note=Nuclear export signal | |
| Tgene | MALT1 | chr11:102201973 | chr18:56363598 | ENST00000345724 | 1 | 16 | 348_562 | 125.33333333333333 | 814.0 | Region | Note=Caspase-like | |
| Tgene | MALT1 | chr11:102201973 | chr18:56363598 | ENST00000348428 | 1 | 17 | 348_562 | 125.33333333333333 | 825.0 | Region | Note=Caspase-like |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BIRC3 | chr11:102201973 | chr18:56363598 | ENST00000263464 | + | 6 | 9 | 439_529 | 441.3333333333333 | 605.0 | Domain | CARD |
| Hgene | BIRC3 | chr11:102201973 | chr18:56363598 | ENST00000532808 | + | 7 | 10 | 439_529 | 441.3333333333333 | 605.0 | Domain | CARD |
| Hgene | BIRC3 | chr11:102201973 | chr18:56363598 | ENST00000263464 | + | 6 | 9 | 557_592 | 441.3333333333333 | 605.0 | Zinc finger | RING-type |
| Hgene | BIRC3 | chr11:102201973 | chr18:56363598 | ENST00000532808 | + | 7 | 10 | 557_592 | 441.3333333333333 | 605.0 | Zinc finger | RING-type |
| Tgene | MALT1 | chr11:102201973 | chr18:56363598 | ENST00000345724 | 1 | 16 | 39_126 | 125.33333333333333 | 814.0 | Domain | Note=Death | |
| Tgene | MALT1 | chr11:102201973 | chr18:56363598 | ENST00000348428 | 1 | 17 | 39_126 | 125.33333333333333 | 825.0 | Domain | Note=Death |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
| PDB file (819) >>>819.pdbFusion protein BP residue: 442 CIF file (819) >>>819.cif | BIRC3 | chr11 | 102201972 | + | MALT1 | chr18 | 56363597 | + | MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSL ARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLN SVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRA NQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPG DRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNL SMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLR CWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSD SPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQ RKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESRIKITVNPE SKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKD AGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPT SQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEH QGTYWCHVYNDRDSQDSKKVEIIIDELNNLGHPDNKEQTTDQPLAKDKVA LLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAV DEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNI LKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQG AEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGK QALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFD CGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKD ANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGL EDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSG GAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHAS | 1129 |
| 3D view using mol* of 819 (AA BP:442) | ||||||||||
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| PDB file (827) >>>827.pdbFusion protein BP residue: 442 CIF file (827) >>>827.cif | BIRC3 | chr11 | 102201972 | + | MALT1 | chr18 | 56363597 | + | MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSL ARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLN SVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRA NQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPG DRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNL SMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLR CWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSD SPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQ RKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESRIKITVNPE SKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKD AGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPT SQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEH QGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQT TDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLL DLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPY RSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTA NIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAE DMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAH ELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTD FPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVF TVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSN GPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPD | 1140 |
| 3D view using mol* of 827 (AA BP:442) | ||||||||||
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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MALT1_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
BIRC3_MALT1_819_pLDDT.png (AA BP:442) |
BIRC3_MALT1_819_pLDDT_and_active_sites.png (AA BP:442) |
BIRC3_MALT1_819_violinplot.png (AA BP:442) |
BIRC3_MALT1_827_pLDDT.png (AA BP:442) |
BIRC3_MALT1_827_pLDDT_and_active_sites.png (AA BP:442) |
BIRC3_MALT1_827_violinplot.png (AA BP:442) |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
| BIRC3_MALT1_819.png |
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| BIRC3_MALT1_827.png |
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Potential Active Site Information |
| The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite. |
| Fusion AA seq ID in FusionPDB | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
| 819 | 0.995 | 561 | 1.025 | 2021.299 | 0.651 | 0.672 | 0.821 | 0.424 | 0.975 | 0.435 | 1.002 | Chain A: 7,8,9,10,11,12,13,14,15,16,17,18,19,20,21 ,23,442,443,444,445,448,477,479,480,505,513,514,51 5,516,517,518,519,595,646,647,669,672,675,676,679, 682,683,684,685,687,806,809,811,812,813,818,821,82 2,869,870,871,872,873,874,875,878,879,880,881,882, 883,885,886,889,890,891,892,893,894,906,908,909,91 0,911,912,913,914,920,954,955,956,962,963,964,965, 966,967,968,969,970,971,972,974,1012,1014,1015,101 6,1019,1103,1104,1105,1106,1107,1108,1109,1110,111 1,1112,1113,1114,1115 |
| 827 | 1.005 | 299 | 1.0397 | 927.129 | 0.6234 | 0.6757 | 0.8555 | 0.4816 | 0.938 | 0.5134 | 0.8696 | Chain A: 4,5,7,8,11,12,15,683,686,687,690,695,698, 890,893,894,896,897,900,901,902,903,904,905,920,92 1,922,923,924,925,931,965,966,967,968,975,976,977, 978,979,980,981,982,983,985,1023,1024,1025,1026,10 27,1030,1115,1116,1117,1118,1119,1120,1121,1122,11 23,1124 |
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Potentially Interacting Small Molecules through Virtual Screening |
| The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide. |
| Fusion AA seq ID in FusionPDB | ZINC ID | DrugBank ID | Drug name | Docking score | Glide gscore |
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| Drug information from DrugBank of the top 20 interacting small molecules. |
| ZINC ID | DrugBank ID | Drug name | Drug type | SMILES | Drug group |
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Biochemical Features of Small Molecules |
| ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9) |
| ZINC ID | mol_MW | dipole | SASA | FOSA | FISA | PISA | WPSA | volume | donorHB | accptHB | IP | Human Oral Absorption | Percent Human Oral Absorption | Rule Of Five | Rule Of Three |
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Drug Toxicity Information |
| Toxicity information of individual drugs using eToxPred |
| ZINC ID | Smile | Surface Accessibility | Toxicity |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| BIRC3 | HTRA2, CASP9, RIPK2, DIABLO, TRAF2, TRAF1, CASP3, CASP7, BCL10, BIRC3, RAF1, TNFRSF1A, UBE2D2, RIPK1, XAF1, UBE2N, BIRC5, UBE2L3, UBE2D1, UBE2D3, UBE2I, UBE2Q2, TRAF3, TRAF6, MAVS, RIPK3, RIPK4, UBXN1, USP19, TRIM32, NOD2, COMMD1, UBC, IKBKG, CASP1, BIRC2, XIAP, E2F1, GSK3B, SEPT4, UBE2V1, IKBKE, TANK, TAB1, RNF31, RBCK1, UBA1, UBR4, WDR1, WDR61, DCAF7, WDR82, USP15, USP7, USP9X, OTUB1, DZIP3, CD40LG, SNX7, SUMO1, RCHY1, CYFIP2, TNFAIP3, EGFR, PACS2, IRF1, SPHK1, MBTPS1, HAX1, CASP8, CASP10, IKBKB, NFKB1, REL, IRF5, EGLN3, LIMA1, TLR3, PELI1, GLMN, YOD1, TNFRSF1B, SART3, JARID2, ACAD9, SEC23A, TARS2, AMOT, ZNF329, RCN2, MMP9, PRDM2, HSP90AB4P, GEMIN5, PBRM1, DNAH5, UBE4A, MYO1D, MAST2, PDXK, DYNC2H1, FLII, TTC3, EIF4G2, INCENP, PARK7, RFC2, OGDH, RPS10, POLR1A, RASAL2, ATR, CDCA2, ZFR, ATP2B3, SLC38A2, MCCC2, ATL2, ACTL6A, PHF5A, ME2, PSMD8, SACM1L, CD47, NCLN, NDUFS8, REXO4, RCC1, HIST2H2BC, ACSL3, MTDH, RPL35, NOC4L, NUP210, VARS, CPSF3, MPHOSPH8, SRSF3, NNT, CPSF1, LETM1, ARL8A, TLN1, SMARCC1, UBE2M, CS, RBM15B, CLINT1, IPO4, RCL1, CC2D2A, GTF3C3, LONP1, EXOSC9, DNPEP, PFAS, KIAA0586, CLTA, DNM1L, PPP5C, VRK1, C1orf35, ANP32E, SNRPB, H3F3A, NPEPPS, ABCF1, UCHL5, ALDH1B1, ZC3HAV1L, SLC25A24, NOL7, MOGS, HARS, BAZ1A, HIST1H2BN, STT3A, G6PD, AP2M1, HNRNPUL1, PUS1, RFC5, URB1, WARS, NIPSNAP3A, COLGALT1, CAPZB, SUCLA2, RPA2, TSG101, TMEM201, PYCR1, ECHS1, RPS17, RPL18A, SLC25A11, HIVEP1, CSNK2B, ZNF280C, TOR1AIP1, AHSA1, EIF2B1, EPHX1, CAMK2B, NOL6, PRDX6, APMAP, PRKAR2A, SLC25A13, GOT2, SMC4, PRC1, UTP15, IPO8, ARPC1A, KDM1A, MBD3, PSMA7, CSTF3, RPRD1B, POR, SEC63, SRSF9, RPL37A, ZRANB2, SFXN3, PGAM5, RBBP5, NUP62, CHCHD3, HSD17B4, MRPS35, COASY, RAD50, PAXBP1, SSB, RALY, BCAP31, DDX42, PSIP1, HSD17B10, HNRNPDL, LMNB2, C14orf166, VDAC2, NDUFS2, KIF3C, HSDL2, AGPS, PGD, LAP3, NSF, TRIP13, WDR6, SMARCAD1, LMNB1, COPB1, SLC25A5, TCERG1, COPG1, MROH8, ATP5F1, COPS4, STT3B, EIF2AK2, PITRM1, RNPEP, DHX38, SRSF1, HK1, RAB9A, RBM22, ATP2B1, BCLAF1, MYBPC1, VDAC1, MRPS27, SPEN, RRP9, SMU1, UTP14A, AIMP1, UBA6, IARS2, CACYBP, PUM1, RPL9, HYOU1, HNRNPC, EIF3H, DENND4A, DDX6, MDN1, RPS16, DARS2, NCAPD2, GLUD1, SNRPD2, EIF5A, ARPC2, NCKAP1, GNL3L, TMEM117, FLOT1, MARS, VPS35, DNAJC8, RPL6, RUVBL2, WDR5, HSPD1, IDH2, DDX24, FKBP3, TSFM, SHMT2, NDUFS3, AQR, TM9SF2, SMARCE1, PRPF4, DNAJC11, SEC11A, PHB2, DLD, TRA2A, HSD17B12, PIM1, TBL3, GARS, EIF2S2, RPL10, ANXA6, RAD21, IARS, DDX54, FTSJ3, KARS, LSG1, PDHB, KTN1, IPO7, PDGFRB, HNRNPA2B1, CSRP2, DIAPH1, ATAD3A, TFRC, CALR, RPL28, SMC1A, TOMM70A, MRPL44, RBM5, DDX1, NBR1, RPL21, MRPS34, PAICS, HNRNPU, NUP98, ERO1L, NUCKS1, RPL35A, RAB7A, HNRNPF, TAGLN2, SLC5A2, ABCE1, XPO5, GCN1L1, DLST, SAMM50, SDHA, RPS12, RPL38, PDIA3, RRP1, TIMM50, DLAT, ZC3HAV1, PHB, HIST1H4A, DDX47, TXNDC5, DDB1, POLD1, U2SURP, VIM, MINA, ZNF280D, TRAP1, TARDBP, HNRNPA3, MDH2, CAP1, PRMT5, RPL14, NAT10, TRA2B, CCT6A, HNRNPR, AAAS, ATP5L, RPS11, RNMTL1, ZNF326, RPL31, UTP3, HIST1H2AD, SFXN1, TMX1, ZC3H15, HIST1H1C, PRKCSH, ACTR3, VDAC3, ANXA5, DDOST, NOMO1, DBT, RPRD1A, ATIC, SUPV3L1, RTN3, ACTG1, ACTR2, ADSL, ERP44, DHX37, HNRNPA0, NUP188, TDRD6, RPL15, RANBP2, ALDH2, QARS, TMEM43, SF1, CCDC86, FARSB, SEC22B, SAFB, CDK2, LMNA, CRNKL1, COX4I1, NUP35, RUVBL1, U2AF1, PRPF6, PNN, EEA1, TRMT10C, WDR46, PGRMC1, THRAP3, WDR12, MLLT4, ELAVL1, SEPT7, HNRNPH1, RPS25, FUBP1, ACLY, GAPVD1, MATR3, FHL1, CAPRIN1, RAB2A, EIF5B, IDH3B, AP3B1, RPS2, HMGCL, H2AFY, AP2A1, SLC25A3, ETF1, POLDIP2, GSR, CBX3, RPF2, MCM3, HADHA, MCOLN2, KPNB1, PRDX3, TLN2, DDX39B, RBMX, PSMD6, APLP2, DAP3, DHCR24, FARSA, PCNA, HSP90B1, SFPQ, PEAK1, SNRPA, SNRNP200, GFM1, TROVE2, PDIA6, DEK, IMMT, TOP2A, RCC2, ALDH3A2, SYNCRIP, SNRNP70, PDE12, ADAR, NUP107, EIF4A3, RAB1A, RPL8, HNRNPM, RPL3, EIF5, GLO1, H2AFZ, ATP5A1, IK, PC, PHGDH, SNRPA1, SNRPD3, PPIB, PSMC4, ALDH18A1, COPB2, SCAMP3, EMC8, RAN, CTPS1, CTTN, IRS4, RPS26, GNB1, RPL18, MYO1B, MDH1, CCT7, RPS27, HMGB1, CHERP, RPS6, MAK16, SKIV2L2, HNRNPD, PRPF8, PDHA1, LARS, SPTAN1, NUMA1, GPD2, YARS, PDCD11, RPS4X, DNMT1, GBA3, FKBP4, PTPLAD1, MRPL37, RRP1B, WDR3, TMED9, MAPK15, BAZ1B, MRTO4, MSH2, PSMD11, TUFM, UQCRC1, THOC1, HADHB, ATP5B, NPM1, NUP205, ASNS, PTCD3, THOC2, CA2, POLRMT, SGOL2, EEF1D, CALU, RPL5, AIFM1, CAND1, PARP1, VAPA, NUP214, PSMB2, MCM2, RPL24, RPL30, EBNA1BP2, RPL10A, ATP2A2, USO1, PSMD12, BSG, CCDC47, SF3A3, PTBP1, HSPE1, PMPCB, PRKDC, RDH11, SSBP1, ERLIN2, FAR1, DKC1, SRSF10, RRP12, DDX5, DHX15, MYO1C, YWHAE, CCT5, CLPB, C1QBP, AUP1, GTF3C1, CLPX, FH, TOMM40, PSMD1, POLDIP3, STIP1, EHD4, SNW1, XRCC5, NEK9, ACAT1, RPL7A, SLC3A2, DNAJC9, RPS3A, SDCBP, NUDC, HSPA5, SRSF7, RBM39, NCL, EFTUD2, MKI67, ATP1A1, NUP155, RPL27A, ALYREF, SND1, PSMB1, WDR43, LYAR, RPL36, DAZAP1, LRRC47, SNRPD1, CKMT1A, EMC1, PABPC1, RPL13A, COPA, PGK1, RPN1, GTPBP4, DDX18, PPP2R1A, EZR, CCT8, HCFC1, MRPS31, PA2G4, PHF6, TOP2B, DHX9, NCBP1, CLTC, ILF3, LMAN2, P4HB, DYNC1LI1, RBM14, NONO, PRPS1, NUP88, PPA1, SMC2, SSRP1, EPRS, GANAB, FLOT2, SF3B3, XRCC6, ACIN1, DDX3X, URB2, SEPT2, RPL17, CHORDC1, AGK, SLC25A22, SSR1, NT5DC2, MTA2, MCM5, DDX21, CDC37, RFC1, ILF2, RANBP1, DIMT1, EPB41L2, H1F0, HNRNPL, NXF1, MYBBP1A, EIF3L, DARS, BAG6, NOP2, NDC1, NOC2L, DBN1, TRIM4, RPSA, FEN1, TXLNA, PFN1, GAR1, PTGES3, EIF3I, CHD1, NOP58, CCT4, SSR4, HSPA8, EIF3D, CMYA5, PSMD3, ACTN4, BCCIP, GNB2L1, AHCY, SCPEP1, PLRG1, RPS15A, U2AF2, RAP1B, GDI2, TCOF1, ACO2, HNRNPH3, RPS9, RPL23A, FN3KRP, PRPF19, NDUFS1, COPS3, UFL1, CKB, SRRM2, RSL1D1, RRP15, ABCD3, CHD4, LRPPRC, HSPH1, SLIRP, RIF1, RANGAP1, XPO1, RPL4, CSE1L, LBR, PRPF40A, RPS23, MYH9, DDX10, SPTBN1, ATXN10, NHP2L1, LDHB, DNTTIP2, CORO1C, SPTLC1, PSMC1, TPI1, ETFA, PSMC3, SRSF2, HNRNPAB, STOML2, DHX16, YBX1, RNPS1, CTNND1, EIF4E, HSP90AB1, MFGE8, GTF3C2, UTP20, TMPO, CAPZA2, CCAR1, NUP50, FBL, GART, RTCB, EIF2S1, DYNC1H1, ATP5O, LRRC59, ATP1B3, SRSF6, RPS8, CKAP5, RNF2, SDHB, ERP29, HAT1, PGAM1, WDR36, GNB1L, RRP7A, PDCD6IP, RPL27, ABCF2, PES1, GLTSCR2, HPRT1, HEATR1, CCT2, RPS13, MTHFD1, SARS, LARP1, SMC3, CDC42, TUBA1B, RPS5, RPL36A, EIF3CL, PPP2R2A, GRSF1, ERAL1, CCT3, MSH6, RPL12, ARF4, SEC31A, ARHGDIA, CANX, IPO5, SRSF5, PCMT1, NHP2, PSMA3, PEF1, BRIX1, MAPRE1, PRDX4, KIF5B, TP53, SF3A1, CYB5R3, PSMD13, KHSRP, SUPT16H, UCHL1, SNRNP40, EIF2S3, API5, PHIP, RPS19, DCAF13, SET, NOP56, SRP68, BMS1, PSMD7, SRRT, EEF2, CFL1, DNHD1, NIFK, CYCS, FANCD2, NDFIP2, SUZ12, STX12, DDX17, RPS20, ANXA2, CBR1, CSNK2A2, TPM3, MCM7, GPI, EIF3B, MAT2A, PDIA4, ESYT1, CCAR2, RPL19, HDLBP, UPF1, DHX30, MTCH2, OAT, CLIC1, RPL22, PSMA6, SNRPB2, DIS3, NUP153, RRBP1, NPM3, SF3B1, POLR2B, NUP133, NSDHL, CRKL, CTBP2, UBAP2L, EIF3E, RPS7, PSMA1, SEC23IP, PDS5B, DDX56, PFKL, TKT, NASP, DDX52, PCBP1, NCAPG, WDR77, RBM15, EIF3A, ATP5C1, THOC3, PPP2CA, HUWE1, PPP1CA, LOC93432, VAPB, ATP6V1A, DDX19A, CAD, IDH3G, OLA1, KIFC1, FASN, GTF3C5, PDS5A, WDR75, RFC3, PPIA, NMD3, MIF, MTHFD1L, PKM, DHCR7, FANCI, SCAMP2, FUBP3, PABPN1, NACA, GNAS, RAB11A, PSME3, SF3B2, STARD9, PELP1, TCP1, IMPDH2, DNAJB1, ENO1, COPE, SRPRB, SAR1A, GNL3, RPN2, RPL7, PYCR2, RPL13, XRN2, GEMIN4, CENPV, SERBP1, DNAJA1, PRDX2, MRPL4, SEC61A1, FLNA, NUP93, ARCN1, BYSL, RPLP2, ARPC4-TTLL3, EEF1G, HDAC1, SEC61B, ST13, BOLA2, TPR, PLA2G15, PRMT1, KHDRBS1, MAGED2, BUB3, CEBPZ, MCM6, UQCRC2, ALDOC, EIF4G1, UBB, COIL, CBS, PLS3, TRIM28, HLA-C, SLC7A5, NDUFV1, UGGT1, SNX2, EXOSC6, PCYOX1, GTF2I, PSMA5, PNPLA8, RBM26, GAPDH, MRE11A, NOLC1, PSMC5, STRAP, DFFA, RPL26L1, KRR1, PSAT1, NUP160, GOLGA4, RPS14, PRDM7, DDX50, VCL, AARS, EIF4A1, WAPAL, AP1M1, HSPA4L, PUF60, PWP2, ATP6V1H, CSNK2A1, SLC1A5, CAPZA1, ENAH, SERPINH1, PRKCD, ASF1A, POGZ, RARS, NOL11, TESK1, EHMT1, UBE3C, CDC5L, DRG1, MYL6, FXR1, NDUFA10, KPNA2, PMPCA, ATP8B4, AKR1B1, PFKM, PSMB5, IDE, RPLP0, LUC7L3, ATP6V0D1, UTP6, SYAP1, RAD23B, EEF1B2, ETFB, PRDX1, ZNF207, GRWD1, ANP32A, DSG2, EMD, PTPN1, SRP72, CKAP4, ALDOA, EDC4, CDK4, TRIO, RPL23, HSPA4, RBM4, MCM4, FAF2, PSMD14, MAP4, G3BP1, PSMD4, ZC3H11A, CHTOP, NOL10, CALCOCO2, SQSTM1, GLOD4, PRKD2, YBX3, KIF23, NCOA5, RBM25, DDX41, LDHA, HNRNPUL2, DNAJA2, LIG3, CSTF1, HIST2H2AB, HDGF, HLA-A, RPS3, CDKN2A, NOL9, RHOA, CTNNBL1, NDUFA4, PPA2, SRP14, RPS18, RPA1, SUPT5H, SLC16A1, PRKAR1A, NUDT4, ARF1, IDH3A, POLR2A, NIPSNAP1, CSNK1E, RACGAP1, RAC1, DPM1, CWC22, FLNB, MYL12A, CDK1, ANP32B, RPS24, RBBP4, SMCHD1, PSMA4, CTR9, CSTB, NME1-NME2, IPO9, EMC2, CIRH1A, EEF1A1, MAT2B, EIF6, HNRNPK, MDC1, GSTP1, TTN, GSPT1, BZW1, RPL7L1, PSMC6, DCTN1, ACTR1A, TMEM33, RPLP1, UBTF, DNAJC7, UTP18, TARS, TXN, H1FX, LANCL2, NAP1L1, CHAF1A, LMAN1, HSPBP1, STAG2, SUPT6H, KRI1, PEBP1, CPSF7, TM9SF3, GLS, MARCKS, RFC4, PRKACA, PLEKHA7, GLUL, KIF11, PAK1IP1, ADSS, KPNA6, DNAJA3, CPOX, PSPC1, CACNA2D2, ATAD2, TFG, MRPS9, KCTD12, CHST13, TALDO1, SLTM, CHMP4B, VPS4A, CNOT1, SAMHD1, DHX36, RTN4, RPTOR, YARS2, RIC8B, EIF3M, GALNT5, NUDT21, ATP13A1, USP10, CLUH, CDC73, AZGP1, SART1, LANCL1, DSP, LOC113230, PROSC, JUP, SPDL1, NAMPT, F2, RPL29, GGCT, APOB, HSPB1, CTSD, GIGYF2, KNTC1, SMC6, ITM2B, DHX29, CHST2, RBM19, RNF20, STX16, ACOT13, DUT, VAT1, G3BP2, DNAH10, MTOR, GFPT1, ANAPC7, TRIM14, PKP1, KIF27, DSG1, DUOX2, PHF2, CLCA2, C1orf68, LTF, GPR125, KPRP, CALML5, BLMH, S100A9, KCTD16, NF1, CDSN, SERPINB12, DSC1, CENPF, SERPINB3, SYNE1, DBNL, GLYR1, CSTA, S100A8, DCD, FASTKD2, TGM3, ADCY4, CCDC38, MLEC, SMARCA5, FUS, HSPA9, IGF2BP1, IQGAP1, RALA, SMARCA4, STAU1, TIMM44, HNRNPA1, CXCR4, ZFAND2A, BECN1, LTBR, CFLAR, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| BIRC3 |  |
| MALT1 |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to BIRC3-MALT1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to BIRC3-MALT1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| BIRC3 | MALT1 | Extranodal Marginal Zone Lymphoma Of Mucosa-Associated Lymphoid Tissue High Grade Ovarian Serous Adenocarcinoma | MyCancerGenome |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BIRC3 | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
| Hgene | BIRC3 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | BIRC3 | C0015695 | Fatty Liver | 1 | CTD_human |
| Hgene | BIRC3 | C0019693 | HIV Infections | 1 | CTD_human |
| Hgene | BIRC3 | C0023418 | leukemia | 1 | CTD_human |
| Hgene | BIRC3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | BIRC3 | C2711227 | Steatohepatitis | 1 | CTD_human |
| Hgene | BIRC3 | C4505456 | HIV Coinfection | 1 | CTD_human |
| Tgene | MALT1 | C3809583 | IMMUNODEFICIENCY 12 | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Tgene | MALT1 | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
| Tgene | MALT1 | C0494261 | Combined immunodeficiency | 1 | GENOMICS_ENGLAND |
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