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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:VAPB-IKZF3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: VAPB-IKZF3
FusionPDB ID: 97893
FusionGDB2.0 ID: 97893
HgeneTgene
Gene symbol

VAPB

IKZF3

Gene ID

9217

22806

Gene nameVAMP associated protein B and CIKAROS family zinc finger 3
SynonymsALS8|VAMP-B|VAP-BAIO|AIOLOS|ZNFN1A3
Cytomap

20q13.32

17q12-q21.1

Type of geneprotein-codingprotein-coding
Descriptionvesicle-associated membrane protein-associated protein B/CVAMP (vesicle-associated membrane protein)-associated protein B and CVAMP-associated 33 kDa proteinzinc finger protein Aioloszinc finger DNA binding protein Aioloszinc finger protein, subfamily 1A, 3 (Aiolos)
Modification date2020031320200327
UniProtAcc.

Q9UKT9

Ensembl transtripts involved in fusion geneENST idsENST00000265619, ENST00000395802, 
ENST00000475243, 		ENST00000346872, 
ENST00000377944, ENST00000394189, 
ENST00000439167, ENST00000535189, 
ENST00000583368, ENST00000346243, 
ENST00000350532, ENST00000351680, 
ENST00000377945, ENST00000377952, 
ENST00000377958, ENST00000439016, 
ENST00000467757, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 5 X 7=42034 X 12 X 14=5712
# samples 1449
** MAII scorelog2(14/420*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(49/5712*10)=-3.54314232502653
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: VAPB [Title/Abstract] AND IKZF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)VAPB(56964573)-IKZF3(37934022), # samples:1
Anticipated loss of major functional domain due to fusion event.VAPB-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
VAPB-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
VAPB-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
VAPB-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneVAPB

GO:0019048

modulation by virus of host morphology or physiology

16227268

HgeneVAPB

GO:0036498

IRE1-mediated unfolded protein response

20940299


check buttonFusion gene breakpoints across VAPB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IKZF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AXX000009VAPBchr20

56964573

+IKZF3chr17

37934022

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000475243VAPBchr2056964573+ENST00000346872IKZF3chr1737934022-20623963381216292
ENST00000475243VAPBchr2056964573+ENST00000394189IKZF3chr1737934022-17233963381216292
ENST00000475243VAPBchr2056964573+ENST00000439167IKZF3chr1737934022-17233963381216292
ENST00000475243VAPBchr2056964573+ENST00000535189IKZF3chr1737934022-17233963381216292
ENST00000475243VAPBchr2056964573+ENST00000377944IKZF3chr1737934022-17233963381216292
ENST00000395802VAPBchr2056964573+ENST00000346872IKZF3chr1737934022-18712051471025292
ENST00000395802VAPBchr2056964573+ENST00000394189IKZF3chr1737934022-15322051471025292
ENST00000395802VAPBchr2056964573+ENST00000439167IKZF3chr1737934022-15322051471025292
ENST00000395802VAPBchr2056964573+ENST00000535189IKZF3chr1737934022-15322051471025292
ENST00000395802VAPBchr2056964573+ENST00000377944IKZF3chr1737934022-15322051471025292

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000475243ENST00000346872VAPBchr2056964573+IKZF3chr1737934022-0.0034116650.99658835
ENST00000475243ENST00000394189VAPBchr2056964573+IKZF3chr1737934022-0.0047805850.9952194
ENST00000475243ENST00000439167VAPBchr2056964573+IKZF3chr1737934022-0.0047805850.9952194
ENST00000475243ENST00000535189VAPBchr2056964573+IKZF3chr1737934022-0.0047805850.9952194
ENST00000475243ENST00000377944VAPBchr2056964573+IKZF3chr1737934022-0.0047805850.9952194
ENST00000395802ENST00000346872VAPBchr2056964573+IKZF3chr1737934022-0.001760630.9982394
ENST00000395802ENST00000394189VAPBchr2056964573+IKZF3chr1737934022-0.002512410.99748755
ENST00000395802ENST00000439167VAPBchr2056964573+IKZF3chr1737934022-0.002512410.99748755
ENST00000395802ENST00000535189VAPBchr2056964573+IKZF3chr1737934022-0.002512410.99748755
ENST00000395802ENST00000377944VAPBchr2056964573+IKZF3chr1737934022-0.002512410.99748755

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>97893_97893_1_VAPB-IKZF3_VAPB_chr20_56964573_ENST00000395802_IKZF3_chr17_37934022_ENST00000346872_length(amino acids)=292AA_BP=19
MAKVEQVLSLEPQHELKFRASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQA
INNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQ
NHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGY

--------------------------------------------------------------

>97893_97893_2_VAPB-IKZF3_VAPB_chr20_56964573_ENST00000395802_IKZF3_chr17_37934022_ENST00000377944_length(amino acids)=292AA_BP=19
MAKVEQVLSLEPQHELKFRASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQA
INNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQ
NHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGY

--------------------------------------------------------------

>97893_97893_3_VAPB-IKZF3_VAPB_chr20_56964573_ENST00000395802_IKZF3_chr17_37934022_ENST00000394189_length(amino acids)=292AA_BP=19
MAKVEQVLSLEPQHELKFRASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQA
INNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQ
NHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGY

--------------------------------------------------------------

>97893_97893_4_VAPB-IKZF3_VAPB_chr20_56964573_ENST00000395802_IKZF3_chr17_37934022_ENST00000439167_length(amino acids)=292AA_BP=19
MAKVEQVLSLEPQHELKFRASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQA
INNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQ
NHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGY

--------------------------------------------------------------

>97893_97893_5_VAPB-IKZF3_VAPB_chr20_56964573_ENST00000395802_IKZF3_chr17_37934022_ENST00000535189_length(amino acids)=292AA_BP=19
MAKVEQVLSLEPQHELKFRASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQA
INNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQ
NHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGY

--------------------------------------------------------------

>97893_97893_6_VAPB-IKZF3_VAPB_chr20_56964573_ENST00000475243_IKZF3_chr17_37934022_ENST00000346872_length(amino acids)=292AA_BP=19
MAKVEQVLSLEPQHELKFRASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQA
INNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQ
NHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGY

--------------------------------------------------------------

>97893_97893_7_VAPB-IKZF3_VAPB_chr20_56964573_ENST00000475243_IKZF3_chr17_37934022_ENST00000377944_length(amino acids)=292AA_BP=19
MAKVEQVLSLEPQHELKFRASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQA
INNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQ
NHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGY

--------------------------------------------------------------

>97893_97893_8_VAPB-IKZF3_VAPB_chr20_56964573_ENST00000475243_IKZF3_chr17_37934022_ENST00000394189_length(amino acids)=292AA_BP=19
MAKVEQVLSLEPQHELKFRASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQA
INNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQ
NHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGY

--------------------------------------------------------------

>97893_97893_9_VAPB-IKZF3_VAPB_chr20_56964573_ENST00000475243_IKZF3_chr17_37934022_ENST00000439167_length(amino acids)=292AA_BP=19
MAKVEQVLSLEPQHELKFRASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQA
INNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQ
NHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGY

--------------------------------------------------------------

>97893_97893_10_VAPB-IKZF3_VAPB_chr20_56964573_ENST00000475243_IKZF3_chr17_37934022_ENST00000535189_length(amino acids)=292AA_BP=19
MAKVEQVLSLEPQHELKFRASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQA
INNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQ
NHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGY

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:56964573/chr17:37934022)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IKZF3

Q9UKT9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269|PubMed:10369681}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIKZF3chr20:56964573chr17:37934022ENST0000034624306118_1400.0432.0Zinc fingerC2H2-type 1
TgeneIKZF3chr20:56964573chr17:37934022ENST0000034624306146_1680.0432.0Zinc fingerC2H2-type 2
TgeneIKZF3chr20:56964573chr17:37934022ENST0000034624306174_1960.0432.0Zinc fingerC2H2-type 3
TgeneIKZF3chr20:56964573chr17:37934022ENST0000034624306202_2240.0432.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000034624306452_4740.0432.0Zinc fingerC2H2-type 5
TgeneIKZF3chr20:56964573chr17:37934022ENST0000034624306480_5040.0432.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000034687258452_474236.33333333333334510.0Zinc fingerC2H2-type 5
TgeneIKZF3chr20:56964573chr17:37934022ENST0000034687258480_504236.33333333333334510.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000035053207118_1400.0471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr20:56964573chr17:37934022ENST0000035053207146_1680.0471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr20:56964573chr17:37934022ENST0000035053207174_1960.0471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr20:56964573chr17:37934022ENST0000035053207202_2240.0471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000035053207452_4740.0471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr20:56964573chr17:37934022ENST0000035053207480_5040.0471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000035168047202_224197.33333333333334471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000035168047452_474197.33333333333334471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr20:56964573chr17:37934022ENST0000035168047480_504197.33333333333334471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037794436118_14093.33333333333333367.0Zinc fingerC2H2-type 1
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037794436146_16893.33333333333333367.0Zinc fingerC2H2-type 2
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037794436174_19693.33333333333333367.0Zinc fingerC2H2-type 3
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037794436202_22493.33333333333333367.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037794436452_47493.33333333333333367.0Zinc fingerC2H2-type 5
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037794436480_50493.33333333333333367.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037794505118_1400376.0Zinc fingerC2H2-type 1
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037794505146_1680376.0Zinc fingerC2H2-type 2
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037794505174_1960376.0Zinc fingerC2H2-type 3
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037794505202_2240376.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037794505452_4740376.0Zinc fingerC2H2-type 5
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037794505480_5040376.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037795204118_1400289.0Zinc fingerC2H2-type 1
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037795204146_1680289.0Zinc fingerC2H2-type 2
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037795204174_1960289.0Zinc fingerC2H2-type 3
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037795204202_2240289.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037795204452_4740289.0Zinc fingerC2H2-type 5
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037795204480_5040289.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037795847174_196149.33333333333334423.0Zinc fingerC2H2-type 3
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037795847202_224149.33333333333334423.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037795847452_474149.33333333333334423.0Zinc fingerC2H2-type 5
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037795847480_504149.33333333333334423.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000039418925118_14054.333333333333336328.0Zinc fingerC2H2-type 1
TgeneIKZF3chr20:56964573chr17:37934022ENST0000039418925146_16854.333333333333336328.0Zinc fingerC2H2-type 2
TgeneIKZF3chr20:56964573chr17:37934022ENST0000039418925174_19654.333333333333336328.0Zinc fingerC2H2-type 3
TgeneIKZF3chr20:56964573chr17:37934022ENST0000039418925202_22454.333333333333336328.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000039418925452_47454.333333333333336328.0Zinc fingerC2H2-type 5
TgeneIKZF3chr20:56964573chr17:37934022ENST0000039418925480_50454.333333333333336328.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000043901636146_168141.33333333333334415.0Zinc fingerC2H2-type 2
TgeneIKZF3chr20:56964573chr17:37934022ENST0000043901636174_196141.33333333333334415.0Zinc fingerC2H2-type 3
TgeneIKZF3chr20:56964573chr17:37934022ENST0000043901636202_224141.33333333333334415.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000043901636452_474141.33333333333334415.0Zinc fingerC2H2-type 5
TgeneIKZF3chr20:56964573chr17:37934022ENST0000043901636480_504141.33333333333334415.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000043916736174_196163.33333333333334437.0Zinc fingerC2H2-type 3
TgeneIKZF3chr20:56964573chr17:37934022ENST0000043916736202_224163.33333333333334437.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000043916736452_474163.33333333333334437.0Zinc fingerC2H2-type 5
TgeneIKZF3chr20:56964573chr17:37934022ENST0000043916736480_504163.33333333333334437.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000046775747202_224180.33333333333334454.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000046775747452_474180.33333333333334454.0Zinc fingerC2H2-type 5
TgeneIKZF3chr20:56964573chr17:37934022ENST0000046775747480_504180.33333333333334454.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000053518947202_224202.33333333333334476.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000053518947452_474202.33333333333334476.0Zinc fingerC2H2-type 5
TgeneIKZF3chr20:56964573chr17:37934022ENST0000053518947480_504202.33333333333334476.0Zinc fingerC2H2-type 6%3B atypical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVAPBchr20:56964573chr17:37934022ENST00000395802+13159_19619.333333333333332100.0Coiled coilOntology_term=ECO:0000255
HgeneVAPBchr20:56964573chr17:37934022ENST00000475243+16159_19619.333333333333332244.0Coiled coilOntology_term=ECO:0000255
HgeneVAPBchr20:56964573chr17:37934022ENST00000395802+137_12419.333333333333332100.0DomainMSP
HgeneVAPBchr20:56964573chr17:37934022ENST00000475243+167_12419.333333333333332244.0DomainMSP
HgeneVAPBchr20:56964573chr17:37934022ENST00000395802+132_22219.333333333333332100.0Topological domainCytoplasmic
HgeneVAPBchr20:56964573chr17:37934022ENST00000475243+162_22219.333333333333332244.0Topological domainCytoplasmic
HgeneVAPBchr20:56964573chr17:37934022ENST00000395802+13223_24319.333333333333332100.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVAPBchr20:56964573chr17:37934022ENST00000475243+16223_24319.333333333333332244.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneIKZF3chr20:56964573chr17:37934022ENST0000034687258118_140236.33333333333334510.0Zinc fingerC2H2-type 1
TgeneIKZF3chr20:56964573chr17:37934022ENST0000034687258146_168236.33333333333334510.0Zinc fingerC2H2-type 2
TgeneIKZF3chr20:56964573chr17:37934022ENST0000034687258174_196236.33333333333334510.0Zinc fingerC2H2-type 3
TgeneIKZF3chr20:56964573chr17:37934022ENST0000034687258202_224236.33333333333334510.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr20:56964573chr17:37934022ENST0000035168047118_140197.33333333333334471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr20:56964573chr17:37934022ENST0000035168047146_168197.33333333333334471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr20:56964573chr17:37934022ENST0000035168047174_196197.33333333333334471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037795847118_140149.33333333333334423.0Zinc fingerC2H2-type 1
TgeneIKZF3chr20:56964573chr17:37934022ENST0000037795847146_168149.33333333333334423.0Zinc fingerC2H2-type 2
TgeneIKZF3chr20:56964573chr17:37934022ENST0000043901636118_140141.33333333333334415.0Zinc fingerC2H2-type 1
TgeneIKZF3chr20:56964573chr17:37934022ENST0000043916736118_140163.33333333333334437.0Zinc fingerC2H2-type 1
TgeneIKZF3chr20:56964573chr17:37934022ENST0000043916736146_168163.33333333333334437.0Zinc fingerC2H2-type 2
TgeneIKZF3chr20:56964573chr17:37934022ENST0000046775747118_140180.33333333333334454.0Zinc fingerC2H2-type 1
TgeneIKZF3chr20:56964573chr17:37934022ENST0000046775747146_168180.33333333333334454.0Zinc fingerC2H2-type 2
TgeneIKZF3chr20:56964573chr17:37934022ENST0000046775747174_196180.33333333333334454.0Zinc fingerC2H2-type 3
TgeneIKZF3chr20:56964573chr17:37934022ENST0000053518947118_140202.33333333333334476.0Zinc fingerC2H2-type 1
TgeneIKZF3chr20:56964573chr17:37934022ENST0000053518947146_168202.33333333333334476.0Zinc fingerC2H2-type 2
TgeneIKZF3chr20:56964573chr17:37934022ENST0000053518947174_196202.33333333333334476.0Zinc fingerC2H2-type 3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
VAPB
IKZF3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to VAPB-IKZF3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to VAPB-IKZF3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource