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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:VDAC2-NEO1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: VDAC2-NEO1
FusionPDB ID: 98012
FusionGDB2.0 ID: 98012
HgeneTgene
Gene symbol

VDAC2

NEO1

Gene ID

7417

4756

Gene namevoltage dependent anion channel 2neogenin 1
SynonymsPORIGDCC2|NGN|NTN1R2
Cytomap

10q22.2

15q24.1

Type of geneprotein-codingprotein-coding
Descriptionvoltage-dependent anion-selective channel protein 2epididymis secretory sperm binding proteinouter mitochondrial membrane protein porin 2neogeninimmunoglobulin superfamily DCC subclass member 2neogenin homolog 1
Modification date2020031320200313
UniProtAcc.

Q92859

Ensembl transtripts involved in fusion geneENST idsENST00000472137, ENST00000332211, 
ENST00000543351, ENST00000313132, 
ENST00000535553, 		ENST00000261908, 
ENST00000339362, ENST00000558964, 
ENST00000560262, ENST00000560352, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 3 X 3=278 X 8 X 4=256
# samples 38
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: VDAC2 [Title/Abstract] AND NEO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)VDAC2(76970947)-NEO1(73408881), # samples:3
Anticipated loss of major functional domain due to fusion event.VDAC2-NEO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
VDAC2-NEO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneVDAC2

GO:0006820

anion transport

8420959


check buttonFusion gene breakpoints across VDAC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NEO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-2A-AAYU-01AVDAC2chr10

76970947

-NEO1chr15

73408881

+
ChimerDB4PRADTCGA-2A-AAYU-01AVDAC2chr10

76970947

+NEO1chr15

73408881

+
ChimerDB4PRADTCGA-2A-AAYUVDAC2chr10

76970947

+NEO1chr15

73408881

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000543351VDAC2chr1076970947+ENST00000339362NEO1chr1573408881+68801158443701428
ENST00000543351VDAC2chr1076970947+ENST00000261908NEO1chr1573408881+68811158443701428
ENST00000543351VDAC2chr1076970947+ENST00000558964NEO1chr1573408881+43601158443371417
ENST00000543351VDAC2chr1076970947+ENST00000560262NEO1chr1573408881+42341158442111375
ENST00000332211VDAC2chr1076970947+ENST00000339362NEO1chr1573408881+700924421344991428
ENST00000332211VDAC2chr1076970947+ENST00000261908NEO1chr1573408881+701024421344991428
ENST00000332211VDAC2chr1076970947+ENST00000558964NEO1chr1573408881+448924421344661417
ENST00000332211VDAC2chr1076970947+ENST00000560262NEO1chr1573408881+436324421343401375

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000543351ENST00000339362VDAC2chr1076970947+NEO1chr1573408881+0.0002000340.9998
ENST00000543351ENST00000261908VDAC2chr1076970947+NEO1chr1573408881+0.0002005270.99979955
ENST00000543351ENST00000558964VDAC2chr1076970947+NEO1chr1573408881+0.0009037840.9990963
ENST00000543351ENST00000560262VDAC2chr1076970947+NEO1chr1573408881+0.000570990.9994289
ENST00000332211ENST00000339362VDAC2chr1076970947+NEO1chr1573408881+0.0002420970.99975795
ENST00000332211ENST00000261908VDAC2chr1076970947+NEO1chr1573408881+0.0002425610.99975747
ENST00000332211ENST00000558964VDAC2chr1076970947+NEO1chr1573408881+0.0010777810.9989222
ENST00000332211ENST00000560262VDAC2chr1076970947+NEO1chr1573408881+0.0006775610.9993224

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>98012_98012_1_VDAC2-NEO1_VDAC2_chr10_76970947_ENST00000332211_NEO1_chr15_73408881_ENST00000261908_length(amino acids)=1428AA_BP=11
MATHGQTCARRASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPD
EGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATE
GDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGG
SLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEH
NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIA
RERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK
LYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQN
GQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTS
IVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINA
PYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVT
KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELT
LDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVG
VITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNS
MDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSL
SDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTP

--------------------------------------------------------------

>98012_98012_2_VDAC2-NEO1_VDAC2_chr10_76970947_ENST00000332211_NEO1_chr15_73408881_ENST00000339362_length(amino acids)=1428AA_BP=11
MATHGQTCARRASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPD
EGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATE
GDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGG
SLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEH
NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIA
RERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK
LYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQN
GQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTS
IVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINA
PYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVT
KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELT
LDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVG
VITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNS
MDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSL
SDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTP

--------------------------------------------------------------

>98012_98012_3_VDAC2-NEO1_VDAC2_chr10_76970947_ENST00000332211_NEO1_chr15_73408881_ENST00000558964_length(amino acids)=1417AA_BP=11
MATHGQTCARRASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPD
EGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATE
GDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGG
SLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEH
NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIA
RERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK
LYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQN
GQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTS
IVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINA
PYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVT
KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELT
LDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIA
VFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNS
YRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVR
NTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHI

--------------------------------------------------------------

>98012_98012_4_VDAC2-NEO1_VDAC2_chr10_76970947_ENST00000332211_NEO1_chr15_73408881_ENST00000560262_length(amino acids)=1375AA_BP=11
MATHGQTCARRASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPD
EGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATE
GDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGG
SLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEH
NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIA
RERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK
LYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQN
GQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTS
IVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINA
PYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVT
KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELT
LDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVG
VITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNS
MDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQQSVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQ
SLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSY

--------------------------------------------------------------

>98012_98012_5_VDAC2-NEO1_VDAC2_chr10_76970947_ENST00000543351_NEO1_chr15_73408881_ENST00000261908_length(amino acids)=1428AA_BP=11
MATHGQTCARRASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPD
EGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATE
GDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGG
SLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEH
NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIA
RERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK
LYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQN
GQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTS
IVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINA
PYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVT
KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELT
LDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVG
VITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNS
MDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSL
SDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTP

--------------------------------------------------------------

>98012_98012_6_VDAC2-NEO1_VDAC2_chr10_76970947_ENST00000543351_NEO1_chr15_73408881_ENST00000339362_length(amino acids)=1428AA_BP=11
MATHGQTCARRASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPD
EGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATE
GDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGG
SLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEH
NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIA
RERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK
LYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQN
GQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTS
IVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINA
PYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVT
KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELT
LDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVG
VITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNS
MDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSL
SDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTP

--------------------------------------------------------------

>98012_98012_7_VDAC2-NEO1_VDAC2_chr10_76970947_ENST00000543351_NEO1_chr15_73408881_ENST00000558964_length(amino acids)=1417AA_BP=11
MATHGQTCARRASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPD
EGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATE
GDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGG
SLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEH
NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIA
RERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK
LYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQN
GQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTS
IVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINA
PYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVT
KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELT
LDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIA
VFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNS
YRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVR
NTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHI

--------------------------------------------------------------

>98012_98012_8_VDAC2-NEO1_VDAC2_chr10_76970947_ENST00000543351_NEO1_chr15_73408881_ENST00000560262_length(amino acids)=1375AA_BP=11
MATHGQTCARRASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPD
EGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATE
GDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGG
SLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEH
NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIA
RERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK
LYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQN
GQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTS
IVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINA
PYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVT
KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELT
LDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVG
VITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNS
MDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQQSVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQ
SLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSY

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:76970947/chr15:73408881)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NEO1

Q92859

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNEO1chr10:76970947chr15:73408881ENST000002619080291118_112143.3333333333333361462.0Compositional biasNote=Poly-Val
TgeneNEO1chr10:76970947chr15:73408881ENST000003393621301118_112143.3333333333333361462.0Compositional biasNote=Poly-Val
TgeneNEO1chr10:76970947chr15:73408881ENST000005589640281118_112143.3333333333333361451.0Compositional biasNote=Poly-Val
TgeneNEO1chr10:76970947chr15:73408881ENST000005602620281118_112143.3333333333333361409.0Compositional biasNote=Poly-Val
TgeneNEO1chr10:76970947chr15:73408881ENST00000261908029152_23843.3333333333333361462.0DomainNote=Ig-like C2-type 2
TgeneNEO1chr10:76970947chr15:73408881ENST00000261908029243_33643.3333333333333361462.0DomainNote=Ig-like C2-type 3
TgeneNEO1chr10:76970947chr15:73408881ENST00000261908029341_42643.3333333333333361462.0DomainNote=Ig-like C2-type 4
TgeneNEO1chr10:76970947chr15:73408881ENST00000261908029441_53543.3333333333333361462.0DomainFibronectin type-III 1
TgeneNEO1chr10:76970947chr15:73408881ENST0000026190802952_14143.3333333333333361462.0DomainNote=Ig-like C2-type 1
TgeneNEO1chr10:76970947chr15:73408881ENST00000261908029541_63143.3333333333333361462.0DomainFibronectin type-III 2
TgeneNEO1chr10:76970947chr15:73408881ENST00000261908029636_73143.3333333333333361462.0DomainFibronectin type-III 3
TgeneNEO1chr10:76970947chr15:73408881ENST00000261908029741_83143.3333333333333361462.0DomainFibronectin type-III 4
TgeneNEO1chr10:76970947chr15:73408881ENST00000261908029856_95243.3333333333333361462.0DomainFibronectin type-III 5
TgeneNEO1chr10:76970947chr15:73408881ENST00000261908029957_105443.3333333333333361462.0DomainFibronectin type-III 6
TgeneNEO1chr10:76970947chr15:73408881ENST00000339362130152_23843.3333333333333361462.0DomainNote=Ig-like C2-type 2
TgeneNEO1chr10:76970947chr15:73408881ENST00000339362130243_33643.3333333333333361462.0DomainNote=Ig-like C2-type 3
TgeneNEO1chr10:76970947chr15:73408881ENST00000339362130341_42643.3333333333333361462.0DomainNote=Ig-like C2-type 4
TgeneNEO1chr10:76970947chr15:73408881ENST00000339362130441_53543.3333333333333361462.0DomainFibronectin type-III 1
TgeneNEO1chr10:76970947chr15:73408881ENST0000033936213052_14143.3333333333333361462.0DomainNote=Ig-like C2-type 1
TgeneNEO1chr10:76970947chr15:73408881ENST00000339362130541_63143.3333333333333361462.0DomainFibronectin type-III 2
TgeneNEO1chr10:76970947chr15:73408881ENST00000339362130636_73143.3333333333333361462.0DomainFibronectin type-III 3
TgeneNEO1chr10:76970947chr15:73408881ENST00000339362130741_83143.3333333333333361462.0DomainFibronectin type-III 4
TgeneNEO1chr10:76970947chr15:73408881ENST00000339362130856_95243.3333333333333361462.0DomainFibronectin type-III 5
TgeneNEO1chr10:76970947chr15:73408881ENST00000339362130957_105443.3333333333333361462.0DomainFibronectin type-III 6
TgeneNEO1chr10:76970947chr15:73408881ENST00000558964028152_23843.3333333333333361451.0DomainNote=Ig-like C2-type 2
TgeneNEO1chr10:76970947chr15:73408881ENST00000558964028243_33643.3333333333333361451.0DomainNote=Ig-like C2-type 3
TgeneNEO1chr10:76970947chr15:73408881ENST00000558964028341_42643.3333333333333361451.0DomainNote=Ig-like C2-type 4
TgeneNEO1chr10:76970947chr15:73408881ENST00000558964028441_53543.3333333333333361451.0DomainFibronectin type-III 1
TgeneNEO1chr10:76970947chr15:73408881ENST0000055896402852_14143.3333333333333361451.0DomainNote=Ig-like C2-type 1
TgeneNEO1chr10:76970947chr15:73408881ENST00000558964028541_63143.3333333333333361451.0DomainFibronectin type-III 2
TgeneNEO1chr10:76970947chr15:73408881ENST00000558964028636_73143.3333333333333361451.0DomainFibronectin type-III 3
TgeneNEO1chr10:76970947chr15:73408881ENST00000558964028741_83143.3333333333333361451.0DomainFibronectin type-III 4
TgeneNEO1chr10:76970947chr15:73408881ENST00000558964028856_95243.3333333333333361451.0DomainFibronectin type-III 5
TgeneNEO1chr10:76970947chr15:73408881ENST00000558964028957_105443.3333333333333361451.0DomainFibronectin type-III 6
TgeneNEO1chr10:76970947chr15:73408881ENST00000560262028152_23843.3333333333333361409.0DomainNote=Ig-like C2-type 2
TgeneNEO1chr10:76970947chr15:73408881ENST00000560262028243_33643.3333333333333361409.0DomainNote=Ig-like C2-type 3
TgeneNEO1chr10:76970947chr15:73408881ENST00000560262028341_42643.3333333333333361409.0DomainNote=Ig-like C2-type 4
TgeneNEO1chr10:76970947chr15:73408881ENST00000560262028441_53543.3333333333333361409.0DomainFibronectin type-III 1
TgeneNEO1chr10:76970947chr15:73408881ENST0000056026202852_14143.3333333333333361409.0DomainNote=Ig-like C2-type 1
TgeneNEO1chr10:76970947chr15:73408881ENST00000560262028541_63143.3333333333333361409.0DomainFibronectin type-III 2
TgeneNEO1chr10:76970947chr15:73408881ENST00000560262028636_73143.3333333333333361409.0DomainFibronectin type-III 3
TgeneNEO1chr10:76970947chr15:73408881ENST00000560262028741_83143.3333333333333361409.0DomainFibronectin type-III 4
TgeneNEO1chr10:76970947chr15:73408881ENST00000560262028856_95243.3333333333333361409.0DomainFibronectin type-III 5
TgeneNEO1chr10:76970947chr15:73408881ENST00000560262028957_105443.3333333333333361409.0DomainFibronectin type-III 6
TgeneNEO1chr10:76970947chr15:73408881ENST000002619080291127_146143.3333333333333361462.0Topological domainCytoplasmic
TgeneNEO1chr10:76970947chr15:73408881ENST000003393621301127_146143.3333333333333361462.0Topological domainCytoplasmic
TgeneNEO1chr10:76970947chr15:73408881ENST000005589640281127_146143.3333333333333361451.0Topological domainCytoplasmic
TgeneNEO1chr10:76970947chr15:73408881ENST000005602620281127_146143.3333333333333361409.0Topological domainCytoplasmic
TgeneNEO1chr10:76970947chr15:73408881ENST000002619080291106_112643.3333333333333361462.0TransmembraneHelical
TgeneNEO1chr10:76970947chr15:73408881ENST000003393621301106_112643.3333333333333361462.0TransmembraneHelical
TgeneNEO1chr10:76970947chr15:73408881ENST000005589640281106_112643.3333333333333361451.0TransmembraneHelical
TgeneNEO1chr10:76970947chr15:73408881ENST000005602620281106_112643.3333333333333361409.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211253_2550310.0Nucleotide bindingNAD
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211271_2750310.0Nucleotide bindingNAD
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210253_25510.333333333333334295.0Nucleotide bindingNAD
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210271_27510.333333333333334295.0Nucleotide bindingNAD
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210253_25510.333333333333334295.0Nucleotide bindingNAD
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210271_27510.333333333333334295.0Nucleotide bindingNAD
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211106_1150310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211122_1310310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211134_1410310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211148_1560310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211161_1690310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211174_1860310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211189_1960310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211200_2090310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211213_2220310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211229_2380310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211242_2490310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211253_2620310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211265_2740310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+211284_2930310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+21137_460310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+21150_580310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+21165_750310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+21180_870310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000313132+21191_1000310.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210106_11510.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210122_13110.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210134_14110.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210148_15610.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210161_16910.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210174_18610.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210189_19610.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210200_20910.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210213_22210.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210229_23810.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210242_24910.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210253_26210.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210265_27410.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+210284_29310.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+21037_4610.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+21050_5810.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+21065_7510.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+21080_8710.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000332211+21091_10010.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210106_11510.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210122_13110.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210134_14110.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210148_15610.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210161_16910.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210174_18610.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210189_19610.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210200_20910.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210213_22210.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210229_23810.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210242_24910.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210253_26210.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210265_27410.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+210284_29310.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+21037_4610.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+21050_5810.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+21065_7510.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+21080_8710.333333333333334295.0TransmembraneBeta stranded
HgeneVDAC2chr10:76970947chr15:73408881ENST00000543351+21091_10010.333333333333334295.0TransmembraneBeta stranded
TgeneNEO1chr10:76970947chr15:73408881ENST0000026190802934_110543.3333333333333361462.0Topological domainExtracellular
TgeneNEO1chr10:76970947chr15:73408881ENST0000033936213034_110543.3333333333333361462.0Topological domainExtracellular
TgeneNEO1chr10:76970947chr15:73408881ENST0000055896402834_110543.3333333333333361451.0Topological domainExtracellular
TgeneNEO1chr10:76970947chr15:73408881ENST0000056026202834_110543.3333333333333361409.0Topological domainExtracellular


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>2050_VDAC2_76970947_NEO1_73408881_ranked_0.pdbVDAC27697094776970947ENST00000560262NEO1chr1573408881+
MATHGQTCARRASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPD
EGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATE
GDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGG
SLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEH
NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIA
RERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK
LYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQN
GQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTS
IVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINA
PYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVT
KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELT
LDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVG
VITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNS
MDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSL
SDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTP
1428


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
VDAC2_pLDDT.png
all structure
all structure
NEO1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
VDAC2
NEO1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to VDAC2-NEO1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to VDAC2-NEO1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource