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Fusion Protein:VIM-IQCG |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: VIM-IQCG | FusionPDB ID: 98114 | FusionGDB2.0 ID: 98114 | Hgene | Tgene | Gene symbol | VIM | IQCG | Gene ID | 7431 | 84223 |
Gene name | vimentin | IQ motif containing G | |
Synonyms | - | CFAP122|DRC9 | |
Cytomap | 10p13 | 3q29 | |
Type of gene | protein-coding | protein-coding | |
Description | vimentinepididymis secretory sperm binding protein | dynein regulatory complex protein 9IQ domain-containing protein Gdynein regulatory complex subunit 9 | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | VMAC | Q9H095 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000224237, ENST00000544301, ENST00000485947, | ENST00000453254, ENST00000455191, ENST00000480302, ENST00000265239, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 38 X 18 X 13=8892 | 12 X 7 X 6=504 |
# samples | 42 | 12 | |
** MAII score | log2(42/8892*10)=-4.40404671536087 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/504*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: VIM [Title/Abstract] AND IQCG [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | VIM(17276823)-IQCG(197686891), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | VIM-IQCG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. VIM-IQCG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. VIM-IQCG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. VIM-IQCG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS5.0 | N/A | CV328902 | VIM | chr10 | 17276823 | + | IQCG | chr3 | 197686891 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000544301 | VIM | chr10 | 17276823 | + | ENST00000265239 | IQCG | chr3 | 197686891 | - | 3683 | 1421 | 1846 | 3177 | 443 |
ENST00000224237 | VIM | chr10 | 17276823 | + | ENST00000265239 | IQCG | chr3 | 197686891 | - | 3415 | 1153 | 1578 | 2909 | 443 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000544301 | ENST00000265239 | VIM | chr10 | 17276823 | + | IQCG | chr3 | 197686891 | - | 0.001888729 | 0.99811125 |
ENST00000224237 | ENST00000265239 | VIM | chr10 | 17276823 | + | IQCG | chr3 | 197686891 | - | 0.001728814 | 0.9982712 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >98114_98114_1_VIM-IQCG_VIM_chr10_17276823_ENST00000224237_IQCG_chr3_197686891_ENST00000265239_length(amino acids)=443AA_BP= MEEDSLEDSNLPPKVWHSEMTVSVTGEPPSTVEEEGIPKETDIEIIPEIPETLEPLSLPDVLRISAVLEDTTDQLSILNYIMPVQYEGRQ SICVKSREMNLEGTNLDKLPMASTITKIPSPLITEEGPNLPEIRHRGRFAVEFNKMQDLVFKKPTRQTIMTTETLKKIQIDRQFFSDVIA DTIKELQDSATYNSLLQALSKERENKMHFYDIIAREEKGRKQIISLQKQLINVKKEWQFEVQSQNEYIANLKDQLQEMKAKSNLENRYMK TNTELQIAQTQKKCNRTEELLVEEIEKLRMKTEEEARTHTEIEMFLRKEQQKLEERLEFWMEKYDKDTEMKQNELNALKATKASDLAHLQ -------------------------------------------------------------- >98114_98114_2_VIM-IQCG_VIM_chr10_17276823_ENST00000544301_IQCG_chr3_197686891_ENST00000265239_length(amino acids)=443AA_BP= MEEDSLEDSNLPPKVWHSEMTVSVTGEPPSTVEEEGIPKETDIEIIPEIPETLEPLSLPDVLRISAVLEDTTDQLSILNYIMPVQYEGRQ SICVKSREMNLEGTNLDKLPMASTITKIPSPLITEEGPNLPEIRHRGRFAVEFNKMQDLVFKKPTRQTIMTTETLKKIQIDRQFFSDVIA DTIKELQDSATYNSLLQALSKERENKMHFYDIIAREEKGRKQIISLQKQLINVKKEWQFEVQSQNEYIANLKDQLQEMKAKSNLENRYMK TNTELQIAQTQKKCNRTEELLVEEIEKLRMKTEEEARTHTEIEMFLRKEQQKLEERLEFWMEKYDKDTEMKQNELNALKATKASDLAHLQ -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:17276823/chr3:197686891) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
VIM | IQCG |
169 | FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. {ECO:0000250|UniProtKB:A3KQH2, ECO:0000250|UniProtKB:A8HQ54, ECO:0000250|UniProtKB:Q80W32}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000224237 | + | 5 | 9 | 154_245 | 336.0 | 467.0 | Coiled coil | Ontology_term=ECO:0000269 |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000224237 | + | 5 | 9 | 96_131 | 336.0 | 467.0 | Coiled coil | Ontology_term=ECO:0000269 |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000544301 | + | 6 | 10 | 154_245 | 336.0 | 467.0 | Coiled coil | Ontology_term=ECO:0000269 |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000544301 | + | 6 | 10 | 96_131 | 336.0 | 467.0 | Coiled coil | Ontology_term=ECO:0000269 |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000224237 | + | 5 | 9 | 326_329 | 336.0 | 467.0 | Motif | [IL]-x-C-x-x-[DE] motif |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000544301 | + | 6 | 10 | 326_329 | 336.0 | 467.0 | Motif | [IL]-x-C-x-x-[DE] motif |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000224237 | + | 5 | 9 | 132_153 | 336.0 | 467.0 | Region | Note=Linker 1 |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000224237 | + | 5 | 9 | 246_268 | 336.0 | 467.0 | Region | Note=Linker 12 |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000224237 | + | 5 | 9 | 2_95 | 336.0 | 467.0 | Region | Note=Head |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000544301 | + | 6 | 10 | 132_153 | 336.0 | 467.0 | Region | Note=Linker 1 |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000544301 | + | 6 | 10 | 246_268 | 336.0 | 467.0 | Region | Note=Linker 12 |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000544301 | + | 6 | 10 | 2_95 | 336.0 | 467.0 | Region | Note=Head |
Tgene | IQCG | chr10:17276823 | chr3:197686891 | ENST00000265239 | -1 | 12 | 393_422 | 0 | 444.0 | Domain | IQ | |
Tgene | IQCG | chr10:17276823 | chr3:197686891 | ENST00000455191 | 0 | 11 | 393_422 | 0 | 444.0 | Domain | IQ |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000224237 | + | 5 | 9 | 303_407 | 336.0 | 467.0 | Coiled coil | Ontology_term=ECO:0000269 |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000544301 | + | 6 | 10 | 303_407 | 336.0 | 467.0 | Coiled coil | Ontology_term=ECO:0000269 |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000224237 | + | 5 | 9 | 103_411 | 336.0 | 467.0 | Domain | IF rod |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000544301 | + | 6 | 10 | 103_411 | 336.0 | 467.0 | Domain | IF rod |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000224237 | + | 5 | 9 | 269_407 | 336.0 | 467.0 | Region | Note=Coil 2 |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000224237 | + | 5 | 9 | 408_466 | 336.0 | 467.0 | Region | Note=Tail |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000544301 | + | 6 | 10 | 269_407 | 336.0 | 467.0 | Region | Note=Coil 2 |
Hgene | VIM | chr10:17276823 | chr3:197686891 | ENST00000544301 | + | 6 | 10 | 408_466 | 336.0 | 467.0 | Region | Note=Tail |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
VIM | |
IQCG |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to VIM-IQCG |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to VIM-IQCG |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |