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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:VPS13B-COX6C

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: VPS13B-COX6C
FusionPDB ID: 98268
FusionGDB2.0 ID: 98268
HgeneTgene
Gene symbol

VPS13B

COX6C

Gene ID

157680

1345

Gene namevacuolar protein sorting 13 homolog Bcytochrome c oxidase subunit 6C
SynonymsCHS1|COH1-
Cytomap

8q22.2

8q22.2

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 13Bcytochrome c oxidase subunit 6Ccytochrome c oxidase polypeptide VIccytochrome c oxidase subunit VIc preproteinepididymis secretory sperm binding protein
Modification date2020031320200313
UniProtAcc.

P09669

Ensembl transtripts involved in fusion geneENST idsENST00000395996, ENST00000355155, 
ENST00000357162, ENST00000358544, 
ENST00000441350, ENST00000521932, 
ENST00000297564, ENST00000517682, 
ENST00000518171, ENST00000520271, 
ENST00000520468, ENST00000522940, 
ENST00000523016, ENST00000524245, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score43 X 36 X 17=2631610 X 8 X 6=480
# samples 5013
** MAII scorelog2(50/26316*10)=-5.71786831273266
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/480*10)=-1.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: VPS13B [Title/Abstract] AND COX6C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)COX6C(100905866)-VPS13B(100883675), # samples:2
VPS13B(100866484)-COX6C(100899846), # samples:1
VPS13B(100026163)-COX6C(100899846), # samples:1
Anticipated loss of major functional domain due to fusion event.VPS13B-COX6C seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
VPS13B-COX6C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across VPS13B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COX6C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A0J9-01AVPS13Bchr8

100866484

+COX6Cchr8

100899846

-
ChimerDB4CESCTCGA-C5-A1MF-01AVPS13Bchr8

100026163

+COX6Cchr8

100899846

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000395996VPS13Bchr8100026163+ENST00000520468COX6Cchr8100899846-78725811137186
ENST00000395996VPS13Bchr8100026163+ENST00000520271COX6Cchr8100899846-50425811137186
ENST00000395996VPS13Bchr8100026163+ENST00000524245COX6Cchr8100899846-50325811137186
ENST00000395996VPS13Bchr8100026163+ENST00000522940COX6Cchr8100899846-50225811137186
ENST00000395996VPS13Bchr8100026163+ENST00000518171COX6Cchr8100899846-77825811137186
ENST00000358544VPS13Bchr8100026163+ENST00000520468COX6Cchr8100899846-78725811137186
ENST00000358544VPS13Bchr8100026163+ENST00000520271COX6Cchr8100899846-50425811137186
ENST00000358544VPS13Bchr8100026163+ENST00000524245COX6Cchr8100899846-50325811137186
ENST00000358544VPS13Bchr8100026163+ENST00000522940COX6Cchr8100899846-50225811137186
ENST00000358544VPS13Bchr8100026163+ENST00000518171COX6Cchr8100899846-77825811137186
ENST00000357162VPS13Bchr8100026163+ENST00000520468COX6Cchr8100899846-78725811137186
ENST00000357162VPS13Bchr8100026163+ENST00000520271COX6Cchr8100899846-50425811137186
ENST00000357162VPS13Bchr8100026163+ENST00000524245COX6Cchr8100899846-50325811137186
ENST00000357162VPS13Bchr8100026163+ENST00000522940COX6Cchr8100899846-50225811137186
ENST00000357162VPS13Bchr8100026163+ENST00000518171COX6Cchr8100899846-77825811137186
ENST00000355155VPS13Bchr8100026163+ENST00000520468COX6Cchr8100899846-78725811137186
ENST00000355155VPS13Bchr8100026163+ENST00000520271COX6Cchr8100899846-50425811137186
ENST00000355155VPS13Bchr8100026163+ENST00000524245COX6Cchr8100899846-50325811137186
ENST00000355155VPS13Bchr8100026163+ENST00000522940COX6Cchr8100899846-50225811137186
ENST00000355155VPS13Bchr8100026163+ENST00000518171COX6Cchr8100899846-77825811137186
ENST00000441350VPS13Bchr8100026163+ENST00000520468COX6Cchr8100899846-77925010336386
ENST00000441350VPS13Bchr8100026163+ENST00000520271COX6Cchr8100899846-49625010336386
ENST00000441350VPS13Bchr8100026163+ENST00000524245COX6Cchr8100899846-49525010336386
ENST00000441350VPS13Bchr8100026163+ENST00000522940COX6Cchr8100899846-49425010336386
ENST00000441350VPS13Bchr8100026163+ENST00000518171COX6Cchr8100899846-77025010336386

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000395996ENST00000520468VPS13Bchr8100026163+COX6Cchr8100899846-0.0929800050.90702
ENST00000395996ENST00000520271VPS13Bchr8100026163+COX6Cchr8100899846-0.0535537040.9464463
ENST00000395996ENST00000524245VPS13Bchr8100026163+COX6Cchr8100899846-0.050380520.9496195
ENST00000395996ENST00000522940VPS13Bchr8100026163+COX6Cchr8100899846-0.0475998070.95240027
ENST00000395996ENST00000518171VPS13Bchr8100026163+COX6Cchr8100899846-0.0533870940.9466129
ENST00000358544ENST00000520468VPS13Bchr8100026163+COX6Cchr8100899846-0.0929800050.90702
ENST00000358544ENST00000520271VPS13Bchr8100026163+COX6Cchr8100899846-0.0535537040.9464463
ENST00000358544ENST00000524245VPS13Bchr8100026163+COX6Cchr8100899846-0.050380520.9496195
ENST00000358544ENST00000522940VPS13Bchr8100026163+COX6Cchr8100899846-0.0475998070.95240027
ENST00000358544ENST00000518171VPS13Bchr8100026163+COX6Cchr8100899846-0.0533870940.9466129
ENST00000357162ENST00000520468VPS13Bchr8100026163+COX6Cchr8100899846-0.0929800050.90702
ENST00000357162ENST00000520271VPS13Bchr8100026163+COX6Cchr8100899846-0.0535537040.9464463
ENST00000357162ENST00000524245VPS13Bchr8100026163+COX6Cchr8100899846-0.050380520.9496195
ENST00000357162ENST00000522940VPS13Bchr8100026163+COX6Cchr8100899846-0.0475998070.95240027
ENST00000357162ENST00000518171VPS13Bchr8100026163+COX6Cchr8100899846-0.0533870940.9466129
ENST00000355155ENST00000520468VPS13Bchr8100026163+COX6Cchr8100899846-0.0929800050.90702
ENST00000355155ENST00000520271VPS13Bchr8100026163+COX6Cchr8100899846-0.0535537040.9464463
ENST00000355155ENST00000524245VPS13Bchr8100026163+COX6Cchr8100899846-0.050380520.9496195
ENST00000355155ENST00000522940VPS13Bchr8100026163+COX6Cchr8100899846-0.0475998070.95240027
ENST00000355155ENST00000518171VPS13Bchr8100026163+COX6Cchr8100899846-0.0533870940.9466129
ENST00000441350ENST00000520468VPS13Bchr8100026163+COX6Cchr8100899846-0.0759455040.92405444
ENST00000441350ENST00000520271VPS13Bchr8100026163+COX6Cchr8100899846-0.048383730.9516163
ENST00000441350ENST00000524245VPS13Bchr8100026163+COX6Cchr8100899846-0.047107060.9528929
ENST00000441350ENST00000522940VPS13Bchr8100026163+COX6Cchr8100899846-0.0468309930.95316905
ENST00000441350ENST00000518171VPS13Bchr8100026163+COX6Cchr8100899846-0.0627651660.9372348

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>98268_98268_1_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000355155_COX6C_chr8_100899846_ENST00000518171_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_2_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000355155_COX6C_chr8_100899846_ENST00000520271_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_3_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000355155_COX6C_chr8_100899846_ENST00000520468_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_4_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000355155_COX6C_chr8_100899846_ENST00000522940_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_5_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000355155_COX6C_chr8_100899846_ENST00000524245_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_6_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000357162_COX6C_chr8_100899846_ENST00000518171_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_7_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000357162_COX6C_chr8_100899846_ENST00000520271_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_8_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000357162_COX6C_chr8_100899846_ENST00000520468_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_9_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000357162_COX6C_chr8_100899846_ENST00000522940_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_10_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000357162_COX6C_chr8_100899846_ENST00000524245_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_11_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000358544_COX6C_chr8_100899846_ENST00000518171_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_12_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000358544_COX6C_chr8_100899846_ENST00000520271_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_13_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000358544_COX6C_chr8_100899846_ENST00000520468_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_14_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000358544_COX6C_chr8_100899846_ENST00000522940_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_15_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000358544_COX6C_chr8_100899846_ENST00000524245_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_16_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000395996_COX6C_chr8_100899846_ENST00000518171_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_17_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000395996_COX6C_chr8_100899846_ENST00000520271_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_18_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000395996_COX6C_chr8_100899846_ENST00000520468_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_19_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000395996_COX6C_chr8_100899846_ENST00000522940_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_20_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000395996_COX6C_chr8_100899846_ENST00000524245_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_21_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000441350_COX6C_chr8_100899846_ENST00000518171_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_22_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000441350_COX6C_chr8_100899846_ENST00000520271_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_23_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000441350_COX6C_chr8_100899846_ENST00000520468_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_24_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000441350_COX6C_chr8_100899846_ENST00000522940_length(amino acids)=86AA_BP=49

--------------------------------------------------------------

>98268_98268_25_VPS13B-COX6C_VPS13B_chr8_100026163_ENST00000441350_COX6C_chr8_100899846_ENST00000524245_length(amino acids)=86AA_BP=49

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:100905866/chr8:100883675)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COX6C

P09669

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P04038}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOX6Cchr8:100026163chr8:100899846ENST000002975641455_7538.096.33333333333333Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005176821455_7538.097.0Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005181711455_7538.0181.33333333333334Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005202711455_7538.049.666666666666664Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005204681455_7538.062.666666666666664Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005229401455_7538.07.333333333333333Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005230161355_7538.076.0Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005242451455_7538.068.33333333333333Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100866484chr8:100899846ENST000002975641455_7538.096.33333333333333Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005176821455_7538.097.0Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005181711455_7538.0181.33333333333334Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005202711455_7538.049.666666666666664Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005204681455_7538.062.666666666666664Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005229401455_7538.07.333333333333333Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005230161355_7538.076.0Topological domainMitochondrial intermembrane
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005242451455_7538.068.33333333333333Topological domainMitochondrial intermembrane

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOX6Cchr8:100026163chr8:100899846ENST00000297564141_1338.096.33333333333333Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100026163chr8:100899846ENST00000517682141_1338.097.0Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100026163chr8:100899846ENST00000518171141_1338.0181.33333333333334Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100026163chr8:100899846ENST00000520271141_1338.049.666666666666664Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100026163chr8:100899846ENST00000520468141_1338.062.666666666666664Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100026163chr8:100899846ENST00000522940141_1338.07.333333333333333Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100026163chr8:100899846ENST00000523016131_1338.076.0Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100026163chr8:100899846ENST00000524245141_1338.068.33333333333333Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100866484chr8:100899846ENST00000297564141_1338.096.33333333333333Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100866484chr8:100899846ENST00000517682141_1338.097.0Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100866484chr8:100899846ENST00000518171141_1338.0181.33333333333334Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100866484chr8:100899846ENST00000520271141_1338.049.666666666666664Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100866484chr8:100899846ENST00000520468141_1338.062.666666666666664Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100866484chr8:100899846ENST00000522940141_1338.07.333333333333333Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100866484chr8:100899846ENST00000523016131_1338.076.0Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100866484chr8:100899846ENST00000524245141_1338.068.33333333333333Topological domainMitochondrial matrix
TgeneCOX6Cchr8:100026163chr8:100899846ENST000002975641414_5438.096.33333333333333TransmembraneHelical
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005176821414_5438.097.0TransmembraneHelical
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005181711414_5438.0181.33333333333334TransmembraneHelical
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005202711414_5438.049.666666666666664TransmembraneHelical
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005204681414_5438.062.666666666666664TransmembraneHelical
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005229401414_5438.07.333333333333333TransmembraneHelical
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005230161314_5438.076.0TransmembraneHelical
TgeneCOX6Cchr8:100026163chr8:100899846ENST000005242451414_5438.068.33333333333333TransmembraneHelical
TgeneCOX6Cchr8:100866484chr8:100899846ENST000002975641414_5438.096.33333333333333TransmembraneHelical
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005176821414_5438.097.0TransmembraneHelical
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005181711414_5438.0181.33333333333334TransmembraneHelical
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005202711414_5438.049.666666666666664TransmembraneHelical
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005204681414_5438.062.666666666666664TransmembraneHelical
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005229401414_5438.07.333333333333333TransmembraneHelical
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005230161314_5438.076.0TransmembraneHelical
TgeneCOX6Cchr8:100866484chr8:100899846ENST000005242451414_5438.068.33333333333333TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
VPS13B
COX6C


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to VPS13B-COX6C


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to VPS13B-COX6C


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource