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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:VPS18-NTRK3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: VPS18-NTRK3
FusionPDB ID: 98337
FusionGDB2.0 ID: 98337
HgeneTgene
Gene symbol

VPS18

NTRK3

Gene ID

57617

4916

Gene nameVPS18 core subunit of CORVET and HOPS complexesneurotrophic receptor tyrosine kinase 3
SynonymsPEP3GP145-TrkC|TRKC|gp145(trkC)
Cytomap

15q15.1

15q25.3

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 18 homologVPS18, CORVET/HOPS core subunithVPS18vacuolar protein sorting 18 homologvacuolar protein sorting protein 18NT-3 growth factor receptorETS related protein-neurotrophic receptor tyrosine kinase fusion proteinETV6-NTRK3 fusionneurotrophic tyrosine kinase, receptor, type 3tyrosine kinase receptor C
Modification date2020031320200313
UniProtAcc.

Q16288

Ensembl transtripts involved in fusion geneENST idsENST00000220509, ENST00000558474, 
ENST00000317501, ENST00000540489, 
ENST00000542733, ENST00000558306, 
ENST00000558676, ENST00000355254, 
ENST00000357724, ENST00000360948, 
ENST00000394480, ENST00000557856, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 3 X 3=2715 X 19 X 11=3135
# samples 315
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/3135*10)=-4.38543103719352
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: VPS18 [Title/Abstract] AND NTRK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)VPS18(41193212)-NTRK3(88423659), # samples:2
Anticipated loss of major functional domain due to fusion event.VPS18-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
VPS18-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
VPS18-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
VPS18-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneVPS18

GO:0007032

endosome organization

18799622

HgeneVPS18

GO:0007040

lysosome organization

18799622

HgeneVPS18

GO:2000300

regulation of synaptic vesicle exocytosis

17027648

TgeneNTRK3

GO:0000187

activation of MAPK activity

23027130

TgeneNTRK3

GO:0001933

negative regulation of protein phosphorylation

23027130

TgeneNTRK3

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

23027130

TgeneNTRK3

GO:0008284

positive regulation of cell proliferation

23027130

TgeneNTRK3

GO:0010628

positive regulation of gene expression

23027130

TgeneNTRK3

GO:0030335

positive regulation of cell migration

23027130

TgeneNTRK3

GO:0032148

activation of protein kinase B activity

23027130

TgeneNTRK3

GO:0033138

positive regulation of peptidyl-serine phosphorylation

23027130

TgeneNTRK3

GO:0050927

positive regulation of positive chemotaxis

23027130

TgeneNTRK3

GO:0090630

activation of GTPase activity

23027130

TgeneNTRK3

GO:2000251

positive regulation of actin cytoskeleton reorganization

23027130


check buttonFusion gene breakpoints across VPS18 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NTRK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-A6-2674-01AVPS18chr15

41193212

-NTRK3chr15

88423659

-
ChimerDB4COADTCGA-A6-2674-01AVPS18chr15

41193212

+NTRK3chr15

88423659

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000220509VPS18chr1541193212+ENST00000394480NTRK3chr1588423659-481625353392879846
ENST00000220509VPS18chr1541193212+ENST00000557856NTRK3chr1588423659-302425353392879846
ENST00000220509VPS18chr1541193212+ENST00000357724NTRK3chr1588423659-302425353392879846
ENST00000220509VPS18chr1541193212+ENST00000355254NTRK3chr1588423659-302425353392879846
ENST00000220509VPS18chr1541193212+ENST00000360948NTRK3chr1588423659-302425353392879846

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000220509ENST00000394480VPS18chr1541193212+NTRK3chr1588423659-0.0030213960.99697864
ENST00000220509ENST00000557856VPS18chr1541193212+NTRK3chr1588423659-0.005983330.99401665
ENST00000220509ENST00000357724VPS18chr1541193212+NTRK3chr1588423659-0.005983330.99401665
ENST00000220509ENST00000355254VPS18chr1541193212+NTRK3chr1588423659-0.005983330.99401665
ENST00000220509ENST00000360948VPS18chr1541193212+NTRK3chr1588423659-0.005983330.99401665

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>98337_98337_1_VPS18-NTRK3_VPS18_chr15_41193212_ENST00000220509_NTRK3_chr15_88423659_ENST00000355254_length(amino acids)=846AA_BP=732
MASILDEYENSLSRSAVLQPGCPSVGIPHSGYVNAQLEKEVPIFTKQRIDFTPSERITSLVVSSNQLCMSLGKDTLLRIDLGKANEPNHV
ELGRKDDAKVHKMFLDHTGSHLLIALSSTEVLYVNRNGQKVRPLARWKGQLVESVGWNKALGTESSTGPILVGTAQGHIFEAELSASEGG
LFGPAPDLYFRPLYVLNEEGGPAPVCSLEAERGPDGRSFVIATTRQRLFQFIGRAAEGAEAQGFSGLFAAYTDHPPPFREFPSNLGYSEL
AFYTPKLRSAPRAFAWMMGDGVLYGALDCGRPDSLLSEERVWEYPEGVGPGASPPLAIVLTQFHFLLLLADRVEAVCTLTGQVVLRDHFL
EKFGPLKHMVKDSSTGQLWAYTERAVFRYHVQREARDVWRTYLDMNRFDLAKEYCRERPDCLDTVLAREADFCFRQRRYLESARCYALTQ
SYFEEIALKFLEARQEEALAEFLQRKLASLKPAERTQATLLTTWLTELYLSRLGALQGDPEALTLYRETKECFRTFLSSPRHKEWLFASR
ASIHELLASHGDTEHMVYFAVIMQDYERVVAYHCQHEAYEEALAVLARHRDPQLFYKFSPILIRHIPRQLVDAWIEMGSRLDARQLIPAL
VNYSQGGEVQQVSQAIRYMEFCVNVLGETEQAIHNYLLSLYARGRPDSLLAYLEQAGASPHRVHYDLKYALRLCAEHGHHRACVHVYKVL
ELYEEAVDLALQVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVM

--------------------------------------------------------------

>98337_98337_2_VPS18-NTRK3_VPS18_chr15_41193212_ENST00000220509_NTRK3_chr15_88423659_ENST00000357724_length(amino acids)=846AA_BP=732
MASILDEYENSLSRSAVLQPGCPSVGIPHSGYVNAQLEKEVPIFTKQRIDFTPSERITSLVVSSNQLCMSLGKDTLLRIDLGKANEPNHV
ELGRKDDAKVHKMFLDHTGSHLLIALSSTEVLYVNRNGQKVRPLARWKGQLVESVGWNKALGTESSTGPILVGTAQGHIFEAELSASEGG
LFGPAPDLYFRPLYVLNEEGGPAPVCSLEAERGPDGRSFVIATTRQRLFQFIGRAAEGAEAQGFSGLFAAYTDHPPPFREFPSNLGYSEL
AFYTPKLRSAPRAFAWMMGDGVLYGALDCGRPDSLLSEERVWEYPEGVGPGASPPLAIVLTQFHFLLLLADRVEAVCTLTGQVVLRDHFL
EKFGPLKHMVKDSSTGQLWAYTERAVFRYHVQREARDVWRTYLDMNRFDLAKEYCRERPDCLDTVLAREADFCFRQRRYLESARCYALTQ
SYFEEIALKFLEARQEEALAEFLQRKLASLKPAERTQATLLTTWLTELYLSRLGALQGDPEALTLYRETKECFRTFLSSPRHKEWLFASR
ASIHELLASHGDTEHMVYFAVIMQDYERVVAYHCQHEAYEEALAVLARHRDPQLFYKFSPILIRHIPRQLVDAWIEMGSRLDARQLIPAL
VNYSQGGEVQQVSQAIRYMEFCVNVLGETEQAIHNYLLSLYARGRPDSLLAYLEQAGASPHRVHYDLKYALRLCAEHGHHRACVHVYKVL
ELYEEAVDLALQVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVM

--------------------------------------------------------------

>98337_98337_3_VPS18-NTRK3_VPS18_chr15_41193212_ENST00000220509_NTRK3_chr15_88423659_ENST00000360948_length(amino acids)=846AA_BP=732
MASILDEYENSLSRSAVLQPGCPSVGIPHSGYVNAQLEKEVPIFTKQRIDFTPSERITSLVVSSNQLCMSLGKDTLLRIDLGKANEPNHV
ELGRKDDAKVHKMFLDHTGSHLLIALSSTEVLYVNRNGQKVRPLARWKGQLVESVGWNKALGTESSTGPILVGTAQGHIFEAELSASEGG
LFGPAPDLYFRPLYVLNEEGGPAPVCSLEAERGPDGRSFVIATTRQRLFQFIGRAAEGAEAQGFSGLFAAYTDHPPPFREFPSNLGYSEL
AFYTPKLRSAPRAFAWMMGDGVLYGALDCGRPDSLLSEERVWEYPEGVGPGASPPLAIVLTQFHFLLLLADRVEAVCTLTGQVVLRDHFL
EKFGPLKHMVKDSSTGQLWAYTERAVFRYHVQREARDVWRTYLDMNRFDLAKEYCRERPDCLDTVLAREADFCFRQRRYLESARCYALTQ
SYFEEIALKFLEARQEEALAEFLQRKLASLKPAERTQATLLTTWLTELYLSRLGALQGDPEALTLYRETKECFRTFLSSPRHKEWLFASR
ASIHELLASHGDTEHMVYFAVIMQDYERVVAYHCQHEAYEEALAVLARHRDPQLFYKFSPILIRHIPRQLVDAWIEMGSRLDARQLIPAL
VNYSQGGEVQQVSQAIRYMEFCVNVLGETEQAIHNYLLSLYARGRPDSLLAYLEQAGASPHRVHYDLKYALRLCAEHGHHRACVHVYKVL
ELYEEAVDLALQVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVM

--------------------------------------------------------------

>98337_98337_4_VPS18-NTRK3_VPS18_chr15_41193212_ENST00000220509_NTRK3_chr15_88423659_ENST00000394480_length(amino acids)=846AA_BP=732
MASILDEYENSLSRSAVLQPGCPSVGIPHSGYVNAQLEKEVPIFTKQRIDFTPSERITSLVVSSNQLCMSLGKDTLLRIDLGKANEPNHV
ELGRKDDAKVHKMFLDHTGSHLLIALSSTEVLYVNRNGQKVRPLARWKGQLVESVGWNKALGTESSTGPILVGTAQGHIFEAELSASEGG
LFGPAPDLYFRPLYVLNEEGGPAPVCSLEAERGPDGRSFVIATTRQRLFQFIGRAAEGAEAQGFSGLFAAYTDHPPPFREFPSNLGYSEL
AFYTPKLRSAPRAFAWMMGDGVLYGALDCGRPDSLLSEERVWEYPEGVGPGASPPLAIVLTQFHFLLLLADRVEAVCTLTGQVVLRDHFL
EKFGPLKHMVKDSSTGQLWAYTERAVFRYHVQREARDVWRTYLDMNRFDLAKEYCRERPDCLDTVLAREADFCFRQRRYLESARCYALTQ
SYFEEIALKFLEARQEEALAEFLQRKLASLKPAERTQATLLTTWLTELYLSRLGALQGDPEALTLYRETKECFRTFLSSPRHKEWLFASR
ASIHELLASHGDTEHMVYFAVIMQDYERVVAYHCQHEAYEEALAVLARHRDPQLFYKFSPILIRHIPRQLVDAWIEMGSRLDARQLIPAL
VNYSQGGEVQQVSQAIRYMEFCVNVLGETEQAIHNYLLSLYARGRPDSLLAYLEQAGASPHRVHYDLKYALRLCAEHGHHRACVHVYKVL
ELYEEAVDLALQVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVM

--------------------------------------------------------------

>98337_98337_5_VPS18-NTRK3_VPS18_chr15_41193212_ENST00000220509_NTRK3_chr15_88423659_ENST00000557856_length(amino acids)=846AA_BP=732
MASILDEYENSLSRSAVLQPGCPSVGIPHSGYVNAQLEKEVPIFTKQRIDFTPSERITSLVVSSNQLCMSLGKDTLLRIDLGKANEPNHV
ELGRKDDAKVHKMFLDHTGSHLLIALSSTEVLYVNRNGQKVRPLARWKGQLVESVGWNKALGTESSTGPILVGTAQGHIFEAELSASEGG
LFGPAPDLYFRPLYVLNEEGGPAPVCSLEAERGPDGRSFVIATTRQRLFQFIGRAAEGAEAQGFSGLFAAYTDHPPPFREFPSNLGYSEL
AFYTPKLRSAPRAFAWMMGDGVLYGALDCGRPDSLLSEERVWEYPEGVGPGASPPLAIVLTQFHFLLLLADRVEAVCTLTGQVVLRDHFL
EKFGPLKHMVKDSSTGQLWAYTERAVFRYHVQREARDVWRTYLDMNRFDLAKEYCRERPDCLDTVLAREADFCFRQRRYLESARCYALTQ
SYFEEIALKFLEARQEEALAEFLQRKLASLKPAERTQATLLTTWLTELYLSRLGALQGDPEALTLYRETKECFRTFLSSPRHKEWLFASR
ASIHELLASHGDTEHMVYFAVIMQDYERVVAYHCQHEAYEEALAVLARHRDPQLFYKFSPILIRHIPRQLVDAWIEMGSRLDARQLIPAL
VNYSQGGEVQQVSQAIRYMEFCVNVLGETEQAIHNYLLSLYARGRPDSLLAYLEQAGASPHRVHYDLKYALRLCAEHGHHRACVHVYKVL
ELYEEAVDLALQVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVM

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:41193212/chr15:88423659)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NTRK3

Q16288

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. {ECO:0000269|PubMed:25196463}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVPS18chr15:41193212chr15:88423659ENST00000220509+45454_481732.0974.0Coiled coilOntology_term=ECO:0000255
TgeneNTRK3chr15:41193212chr15:88423659ENST00000317501015160_2090613.0DomainNote=LRRCT
TgeneNTRK3chr15:41193212chr15:88423659ENST00000317501015210_3000613.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr15:41193212chr15:88423659ENST00000317501015309_3820613.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr15:41193212chr15:88423659ENST00000317501015538_8390613.0DomainProtein kinase
TgeneNTRK3chr15:41193212chr15:88423659ENST00000540489014160_2090613.0DomainNote=LRRCT
TgeneNTRK3chr15:41193212chr15:88423659ENST00000540489014210_3000613.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr15:41193212chr15:88423659ENST00000540489014309_3820613.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr15:41193212chr15:88423659ENST00000540489014538_8390613.0DomainProtein kinase
TgeneNTRK3chr15:41193212chr15:88423659ENST00000317501015544_5520613.0Nucleotide bindingATP
TgeneNTRK3chr15:41193212chr15:88423659ENST00000540489014544_5520613.0Nucleotide bindingATP
TgeneNTRK3chr15:41193212chr15:88423659ENST00000317501015104_1250613.0RepeatNote=LRR 1
TgeneNTRK3chr15:41193212chr15:88423659ENST00000317501015128_1490613.0RepeatNote=LRR 2
TgeneNTRK3chr15:41193212chr15:88423659ENST00000540489014104_1250613.0RepeatNote=LRR 1
TgeneNTRK3chr15:41193212chr15:88423659ENST00000540489014128_1490613.0RepeatNote=LRR 2
TgeneNTRK3chr15:41193212chr15:88423659ENST0000031750101532_4290613.0Topological domainExtracellular
TgeneNTRK3chr15:41193212chr15:88423659ENST00000317501015454_8390613.0Topological domainCytoplasmic
TgeneNTRK3chr15:41193212chr15:88423659ENST0000054048901432_4290613.0Topological domainExtracellular
TgeneNTRK3chr15:41193212chr15:88423659ENST00000540489014454_8390613.0Topological domainCytoplasmic
TgeneNTRK3chr15:41193212chr15:88423659ENST00000317501015430_4530613.0TransmembraneHelical
TgeneNTRK3chr15:41193212chr15:88423659ENST00000540489014430_4530613.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVPS18chr15:41193212chr15:88423659ENST00000220509+45802_848732.0974.0Coiled coilOntology_term=ECO:0000255
HgeneVPS18chr15:41193212chr15:88423659ENST00000220509+45618_772732.0974.0RepeatNote=CHCR
HgeneVPS18chr15:41193212chr15:88423659ENST00000220509+45853_947732.0974.0Zinc fingerNote=RING-type
TgeneNTRK3chr15:41193212chr15:88423659ENST000003552541518160_209711.0826.0DomainNote=LRRCT
TgeneNTRK3chr15:41193212chr15:88423659ENST000003552541518210_300711.0826.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr15:41193212chr15:88423659ENST000003552541518309_382711.0826.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr15:41193212chr15:88423659ENST000003552541518538_839711.0826.0DomainProtein kinase
TgeneNTRK3chr15:41193212chr15:88423659ENST000003609481619160_209725.0840.0DomainNote=LRRCT
TgeneNTRK3chr15:41193212chr15:88423659ENST000003609481619210_300725.0840.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr15:41193212chr15:88423659ENST000003609481619309_382725.0840.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr15:41193212chr15:88423659ENST000003609481619538_839725.0840.0DomainProtein kinase
TgeneNTRK3chr15:41193212chr15:88423659ENST000003944801619160_209711.0826.0DomainNote=LRRCT
TgeneNTRK3chr15:41193212chr15:88423659ENST000003944801619210_300711.0826.0DomainNote=Ig-like C2-type 1
TgeneNTRK3chr15:41193212chr15:88423659ENST000003944801619309_382711.0826.0DomainNote=Ig-like C2-type 2
TgeneNTRK3chr15:41193212chr15:88423659ENST000003944801619538_839711.0826.0DomainProtein kinase
TgeneNTRK3chr15:41193212chr15:88423659ENST000003552541518544_552711.0826.0Nucleotide bindingATP
TgeneNTRK3chr15:41193212chr15:88423659ENST000003609481619544_552725.0840.0Nucleotide bindingATP
TgeneNTRK3chr15:41193212chr15:88423659ENST000003944801619544_552711.0826.0Nucleotide bindingATP
TgeneNTRK3chr15:41193212chr15:88423659ENST000003552541518104_125711.0826.0RepeatNote=LRR 1
TgeneNTRK3chr15:41193212chr15:88423659ENST000003552541518128_149711.0826.0RepeatNote=LRR 2
TgeneNTRK3chr15:41193212chr15:88423659ENST000003609481619104_125725.0840.0RepeatNote=LRR 1
TgeneNTRK3chr15:41193212chr15:88423659ENST000003609481619128_149725.0840.0RepeatNote=LRR 2
TgeneNTRK3chr15:41193212chr15:88423659ENST000003944801619104_125711.0826.0RepeatNote=LRR 1
TgeneNTRK3chr15:41193212chr15:88423659ENST000003944801619128_149711.0826.0RepeatNote=LRR 2
TgeneNTRK3chr15:41193212chr15:88423659ENST00000355254151832_429711.0826.0Topological domainExtracellular
TgeneNTRK3chr15:41193212chr15:88423659ENST000003552541518454_839711.0826.0Topological domainCytoplasmic
TgeneNTRK3chr15:41193212chr15:88423659ENST00000360948161932_429725.0840.0Topological domainExtracellular
TgeneNTRK3chr15:41193212chr15:88423659ENST000003609481619454_839725.0840.0Topological domainCytoplasmic
TgeneNTRK3chr15:41193212chr15:88423659ENST00000394480161932_429711.0826.0Topological domainExtracellular
TgeneNTRK3chr15:41193212chr15:88423659ENST000003944801619454_839711.0826.0Topological domainCytoplasmic
TgeneNTRK3chr15:41193212chr15:88423659ENST000003552541518430_453711.0826.0TransmembraneHelical
TgeneNTRK3chr15:41193212chr15:88423659ENST000003609481619430_453725.0840.0TransmembraneHelical
TgeneNTRK3chr15:41193212chr15:88423659ENST000003944801619430_453711.0826.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NTRK3NTF3, FRS2, SHC1, PLCG1, SQSTM1, PTPN1, APP, HSP90AA1, IRAK3, TNK2, NTRK1, SH3BP4, PTPRS, MYADM, C1GALT1, GNB2, C6orf120, MTOR, LGALS1, PTCD2, TMEM11, PAG1, EFR3A, TBC1D24, GNB4, TMEM192, INTS7, DENND4A, FAM171A2, KIAA0391, EPHA2, ATP7B, CXCR4, ACAD10, HRAS, EHD4, RPTOR, HEATR6, SLC39A11, NDFIP1, ERBB2, NELFB, HEY1, WDR13, KPNA4, NSD1, DOK6, SORT1, Ngfr, DDX58, UBE3C, LINGO1, NEU3, ACAD9,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
VPS18
NTRK3all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to VPS18-NTRK3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to VPS18-NTRK3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNTRK3C0036341Schizophrenia3PSYGENET
TgeneNTRK3C0041696Unipolar Depression2PSYGENET
TgeneNTRK3C1269683Major Depressive Disorder2PSYGENET
TgeneNTRK3C1332965Congenital Mesoblastic Nephroma2ORPHANET
TgeneNTRK3C0014175Endometriosis1CTD_human
TgeneNTRK3C0017638Glioma1CTD_human
TgeneNTRK3C0019569Hirschsprung Disease1GENOMICS_ENGLAND
TgeneNTRK3C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneNTRK3C0026998Acute Myeloid Leukemia, M11CTD_human
TgeneNTRK3C0038220Status Epilepticus1CTD_human
TgeneNTRK3C0238463Papillary thyroid carcinoma1ORPHANET
TgeneNTRK3C0259783mixed gliomas1CTD_human
TgeneNTRK3C0269102Endometrioma1CTD_human
TgeneNTRK3C0270823Petit mal status1CTD_human
TgeneNTRK3C0311335Grand Mal Status Epilepticus1CTD_human
TgeneNTRK3C0393734Complex Partial Status Epilepticus1CTD_human
TgeneNTRK3C0525045Mood Disorders1PSYGENET
TgeneNTRK3C0555198Malignant Glioma1CTD_human
TgeneNTRK3C0751522Status Epilepticus, Subclinical1CTD_human
TgeneNTRK3C0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneNTRK3C0751524Simple Partial Status Epilepticus1CTD_human
TgeneNTRK3C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human