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Fusion Protein:VPS53-LRP1B |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: VPS53-LRP1B | FusionPDB ID: 98483 | FusionGDB2.0 ID: 98483 | Hgene | Tgene | Gene symbol | VPS53 | LRP1B | Gene ID | 55275 | 53353 |
| Gene name | VPS53 subunit of GARP complex | LDL receptor related protein 1B | |
| Synonyms | HCCS1|PCH2E|hVps53L|pp13624 | LRP-1B|LRP-DIT|LRPDIT | |
| Cytomap | 17p13.3 | 2q22.1-q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vacuolar protein sorting-associated protein 53 homologVPS53, GARP complex subunit | low-density lipoprotein receptor-related protein 1BLRP-deleted in tumorslow density lipoprotein receptor related protein-deleted in tumorlow density lipoprotein receptor-related protein 1Blow density lipoprotein-related protein 1B (deleted in tumors) | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q9NZR2 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000291074, ENST00000401468, ENST00000437048, ENST00000446250, ENST00000571805, ENST00000576149, ENST00000574029, | ENST00000486364, ENST00000389484, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 18 X 15 X 14=3780 | 12 X 13 X 5=780 |
| # samples | 24 | 13 | |
| ** MAII score | log2(24/3780*10)=-3.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/780*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: VPS53 [Title/Abstract] AND LRP1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | VPS53(463666)-LRP1B(142012210), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | VPS53-LRP1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. VPS53-LRP1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. VPS53-LRP1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. VPS53-LRP1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. VPS53-LRP1B seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. VPS53-LRP1B seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. VPS53-LRP1B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. VPS53-LRP1B seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across VPS53 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across LRP1B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | UCEC | TCGA-AJ-A3NF-01A | VPS53 | chr17 | 463666 | - | LRP1B | chr2 | 142012210 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000446250 | VPS53 | chr17 | 463666 | - | ENST00000389484 | LRP1B | chr2 | 142012210 | - | 17169 | 1949 | 1927 | 15405 | 4492 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000446250 | ENST00000389484 | VPS53 | chr17 | 463666 | - | LRP1B | chr2 | 142012210 | - | 0.00146098 | 0.998539 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >98483_98483_1_VPS53-LRP1B_VPS53_chr17_463666_ENST00000446250_LRP1B_chr2_142012210_ENST00000389484_length(amino acids)=4492AA_BP=7 MSGHHPAELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKI EPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQ MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALAL DLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQKRTQ PTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVN PRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHP RGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRE LNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLD ENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDE SNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCF DNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDH KTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHC SVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHK RDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGS LRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGT NMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLIN HNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFING TGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKI LFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNK TSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPIS GTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQ PRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMF SVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGYLAE DGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVEN VGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVV VSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIP HQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCK DKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNN TDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCD SSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDE NAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFM CKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYG TYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNG SDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSV VIETKISRPMALTIDYVNRRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHA ITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSD EPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCS PDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDC VSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEY DCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAP DMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCR IAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSED QVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVD WVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQ KNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDK TKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGER CEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTI GDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCE RPAPKSSKSDHISTRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHNDGGLLDPGFMID -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:463666/chr2:142012210) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | LRP1B |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | VPS53 | chr17:463666 | chr2:142012210 | ENST00000291074 | - | 14 | 18 | 97_138 | 539.0 | 671.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | VPS53 | chr17:463666 | chr2:142012210 | ENST00000437048 | - | 15 | 22 | 97_138 | 568.0 | 833.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | VPS53 | chr17:463666 | chr2:142012210 | ENST00000571805 | - | 15 | 19 | 97_138 | 568.0 | 700.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1005_1043 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 7 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1052_1089 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 8 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1094_1132 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 9 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1135_1174 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 10 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 116_154 | 114.33333333333333 | 4600.0 | Domain | EGF-like 1 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1174_1213 | 114.33333333333333 | 4600.0 | Domain | EGF-like 5 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1214_1253 | 114.33333333333333 | 4600.0 | Domain | EGF-like 6 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1527_1570 | 114.33333333333333 | 4600.0 | Domain | EGF-like 7 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 155_194 | 114.33333333333333 | 4600.0 | Domain | EGF-like 2%3B calcium-binding | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1834_1875 | 114.33333333333333 | 4600.0 | Domain | EGF-like 8 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2143_2183 | 114.33333333333333 | 4600.0 | Domain | EGF-like 9 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2464_2504 | 114.33333333333333 | 4600.0 | Domain | EGF-like 10 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2509_2548 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 11 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2551_2587 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 12 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2590_2626 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 13 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2629_2675 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 14 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2681_2717 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 15 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2719_2757 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 16 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2760_2800 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 17 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2804_2841 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 18 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2844_2885 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 19 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2890_2926 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 20 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2927_2967 | 114.33333333333333 | 4600.0 | Domain | EGF-like 11 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2968_3008 | 114.33333333333333 | 4600.0 | Domain | EGF-like 12%3B calcium-binding | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3273_3314 | 114.33333333333333 | 4600.0 | Domain | EGF-like 13 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3316_3353 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 21 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3356_3392 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 22 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3395_3432 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 23 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3435_3472 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 24 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3475_3511 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 25 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3514_3550 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 26 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3552_3588 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 27 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3593_3629 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 28 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3631_3668 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 29 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3673_3711 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 30 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3714_3752 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 31 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3761_3797 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 32 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3801_3843 | 114.33333333333333 | 4600.0 | Domain | EGF-like 14 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3844_3881 | 114.33333333333333 | 4600.0 | Domain | EGF-like 15 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 4171_4208 | 114.33333333333333 | 4600.0 | Domain | EGF-like 16 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 4213_4249 | 114.33333333333333 | 4600.0 | Domain | EGF-like 17 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 4249_4285 | 114.33333333333333 | 4600.0 | Domain | EGF-like 18 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 4285_4321 | 114.33333333333333 | 4600.0 | Domain | EGF-like 19 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 4321_4357 | 114.33333333333333 | 4600.0 | Domain | EGF-like 20 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 4357_4392 | 114.33333333333333 | 4600.0 | Domain | EGF-like 21 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 4390_4427 | 114.33333333333333 | 4600.0 | Domain | EGF-like 22 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 471_517 | 114.33333333333333 | 4600.0 | Domain | EGF-like 3 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 794_834 | 114.33333333333333 | 4600.0 | Domain | EGF-like 4 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 844_882 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 3 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 885_923 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 4 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 926_963 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 5 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 966_1003 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 6 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 4492_4495 | 114.33333333333333 | 4600.0 | Motif | Endocytosis signal | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 4559_4562 | 114.33333333333333 | 4600.0 | Motif | Endocytosis signal | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1300_1346 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 8 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1347_1389 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 9 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1390_1436 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 10 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1437_1480 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 11 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1481_1522 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 12 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1618_1660 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 13 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1661_1704 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 14 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1705_1744 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 15 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1745_1787 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 16 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1922_1964 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 17 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 1965_2007 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 28 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2008_2051 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 19 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2052_2095 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 20 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2239_2280 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 21 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2281_2329 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 22 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2330_2374 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 23 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2375_2416 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 24 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 2417_2459 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 25 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 295_337 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 1 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3055_3098 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 26 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3099_3141 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 27 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3142_3185 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 28 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3186_3224 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 29 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3225_3268 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 30 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 338_381 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 2 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 382_425 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 3 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3933_3980 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 31 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 3981_4038 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 32 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 4039_4082 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 33 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 4083_4127 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 34 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 568_610 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 4 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 611_656 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 5 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 657_706 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 6 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 707_750 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 7 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 4468_4599 | 114.33333333333333 | 4600.0 | Topological domain | Cytoplasmic | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 4445_4467 | 114.33333333333333 | 4600.0 | Transmembrane | Helical |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 31_70 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 1 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 76_114 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 2 | |
| Tgene | LRP1B | chr17:463666 | chr2:142012210 | ENST00000389484 | 2 | 91 | 25_4444 | 114.33333333333333 | 4600.0 | Topological domain | Extracellular |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| VPS53 | |
| LRP1B |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to VPS53-LRP1B |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to VPS53-LRP1B |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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