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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:VWA2-TCF7L2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: VWA2-TCF7L2
FusionPDB ID: 98611
FusionGDB2.0 ID: 98611
HgeneTgene
Gene symbol

VWA2

TCF7L2

Gene ID

340706

6934

Gene namevon Willebrand factor A domain containing 2transcription factor 7 like 2
SynonymsAMACO|CCSP-2|CCSP2|NET42TCF-4|TCF4
Cytomap

10q25.3

10q25.2-q25.3

Type of geneprotein-codingprotein-coding
Descriptionvon Willebrand factor A domain-containing protein 2a domain-containing protein similar to matrilin and collagencolon cancer diagnostic markercolon cancer secreted protein 2transcription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box)
Modification date2020031320200315
UniProtAcc

Q5GFL6

Q9NQB0

Ensembl transtripts involved in fusion geneENST idsENST00000392982, ENST00000603594, 
ENST00000542695, ENST00000369386, 
ENST00000369389, ENST00000466338, 
ENST00000349937, ENST00000352065, 
ENST00000355717, ENST00000355995, 
ENST00000369395, ENST00000369397, 
ENST00000534894, ENST00000536810, 
ENST00000538897, ENST00000543371, 
ENST00000545257, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 2 X 2=812 X 11 X 10=1320
# samples 217
** MAII scorelog2(2/8*10)=1.32192809488736log2(17/1320*10)=-2.95693127810811
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: VWA2 [Title/Abstract] AND TCF7L2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.VWA2-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
VWA2-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
VWA2-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF.
VWA2-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF.
VWA2-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor by not retaining the major functional domain in the partially deleted in-frame ORF.
VWA2-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTCF7L2

GO:0000122

negative regulation of transcription by RNA polymerase II

12799378

TgeneTCF7L2

GO:0006357

regulation of transcription by RNA polymerase II

9727977

TgeneTCF7L2

GO:0032092

positive regulation of protein binding

12799378

TgeneTCF7L2

GO:0032350

regulation of hormone metabolic process

15525634

TgeneTCF7L2

GO:0042593

glucose homeostasis

15525634

TgeneTCF7L2

GO:0043433

negative regulation of DNA-binding transcription factor activity

12799378

TgeneTCF7L2

GO:0045444

fat cell differentiation

10937998

TgeneTCF7L2

GO:0045892

negative regulation of transcription, DNA-templated

12799378|15525634

TgeneTCF7L2

GO:0045944

positive regulation of transcription by RNA polymerase II

9065401|19168596

TgeneTCF7L2

GO:0048625

myoblast fate commitment

10937998


check buttonFusion gene breakpoints across VWA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TCF7L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB4..VWA2chr10

116014807

TCF7L2chr10

114900943



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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000603594VWA2chr10116014807ENST00000534894TCF7L2chr1011490094315155823211514397
ENST00000603594VWA2chr10116014807ENST00000536810TCF7L2chr1011490094335455823211838505
ENST00000603594VWA2chr10116014807ENST00000545257TCF7L2chr1011490094335965823211889522
ENST00000603594VWA2chr10116014807ENST00000355995TCF7L2chr1011490094335965823211889522
ENST00000603594VWA2chr10116014807ENST00000543371TCF7L2chr1011490094335455823211838505
ENST00000603594VWA2chr10116014807ENST00000355717TCF7L2chr1011490094334725823211427368
ENST00000603594VWA2chr10116014807ENST00000538897TCF7L2chr1011490094335235823211478385
ENST00000603594VWA2chr10116014807ENST00000349937TCF7L2chr10114900943899582321896191
ENST00000603594VWA2chr10116014807ENST00000369397TCF7L2chr1011490094335965823211889522
ENST00000603594VWA2chr10116014807ENST00000352065TCF7L2chr1011490094315555823211478385
ENST00000603594VWA2chr10116014807ENST00000369395TCF7L2chr10114900943911582321908195
ENST00000392982VWA2chr10116014807ENST00000534894TCF7L2chr1011490094314445112501443398
ENST00000392982VWA2chr10116014807ENST00000536810TCF7L2chr1011490094334745112501767505
ENST00000392982VWA2chr10116014807ENST00000545257TCF7L2chr1011490094335255112501818522
ENST00000392982VWA2chr10116014807ENST00000355995TCF7L2chr1011490094335255112501818522
ENST00000392982VWA2chr10116014807ENST00000543371TCF7L2chr1011490094334745112501767505
ENST00000392982VWA2chr10116014807ENST00000355717TCF7L2chr1011490094334015112501356368
ENST00000392982VWA2chr10116014807ENST00000538897TCF7L2chr1011490094334525112501407385
ENST00000392982VWA2chr10116014807ENST00000349937TCF7L2chr10114900943828511250825191
ENST00000392982VWA2chr10116014807ENST00000369397TCF7L2chr1011490094335255112501818522
ENST00000392982VWA2chr10116014807ENST00000352065TCF7L2chr1011490094314845112501407385
ENST00000392982VWA2chr10116014807ENST00000369395TCF7L2chr10114900943840511250837195

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>98611_98611_1_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000392982_TCF7L2_chr10_114900943_ENST00000349937_length(amino acids)=191AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWQGQPVYPITTGGFRHPYP

--------------------------------------------------------------

>98611_98611_2_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000392982_TCF7L2_chr10_114900943_ENST00000352065_length(amino acids)=385AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITD

--------------------------------------------------------------

>98611_98611_3_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000392982_TCF7L2_chr10_114900943_ENST00000355717_length(amino acids)=368AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNGEKKSAFATYKVKAAASA

--------------------------------------------------------------

>98611_98611_4_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000392982_TCF7L2_chr10_114900943_ENST00000355995_length(amino acids)=522AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITD
LSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLS

--------------------------------------------------------------

>98611_98611_5_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000392982_TCF7L2_chr10_114900943_ENST00000369395_length(amino acids)=195AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR

--------------------------------------------------------------

>98611_98611_6_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000392982_TCF7L2_chr10_114900943_ENST00000369397_length(amino acids)=522AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITD
LSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLS

--------------------------------------------------------------

>98611_98611_7_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000392982_TCF7L2_chr10_114900943_ENST00000534894_length(amino acids)=398AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITD

--------------------------------------------------------------

>98611_98611_8_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000392982_TCF7L2_chr10_114900943_ENST00000536810_length(amino acids)=505AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDLSAPKKCRARFGLDQQN
NWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKA

--------------------------------------------------------------

>98611_98611_9_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000392982_TCF7L2_chr10_114900943_ENST00000538897_length(amino acids)=385AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITG

--------------------------------------------------------------

>98611_98611_10_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000392982_TCF7L2_chr10_114900943_ENST00000543371_length(amino acids)=505AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDANTPKKCRALFGLDRQT
LWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKA

--------------------------------------------------------------

>98611_98611_11_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000392982_TCF7L2_chr10_114900943_ENST00000545257_length(amino acids)=522AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITD
ANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLS

--------------------------------------------------------------

>98611_98611_12_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000603594_TCF7L2_chr10_114900943_ENST00000349937_length(amino acids)=191AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWQGQPVYPITTGGFRHPYP

--------------------------------------------------------------

>98611_98611_13_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000603594_TCF7L2_chr10_114900943_ENST00000352065_length(amino acids)=385AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITD

--------------------------------------------------------------

>98611_98611_14_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000603594_TCF7L2_chr10_114900943_ENST00000355717_length(amino acids)=368AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNGEKKSAFATYKVKAAASA

--------------------------------------------------------------

>98611_98611_15_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000603594_TCF7L2_chr10_114900943_ENST00000355995_length(amino acids)=522AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITD
LSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLS

--------------------------------------------------------------

>98611_98611_16_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000603594_TCF7L2_chr10_114900943_ENST00000369395_length(amino acids)=195AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR

--------------------------------------------------------------

>98611_98611_17_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000603594_TCF7L2_chr10_114900943_ENST00000369397_length(amino acids)=522AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITD
LSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLS

--------------------------------------------------------------

>98611_98611_18_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000603594_TCF7L2_chr10_114900943_ENST00000534894_length(amino acids)=397AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITD

--------------------------------------------------------------

>98611_98611_19_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000603594_TCF7L2_chr10_114900943_ENST00000536810_length(amino acids)=505AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDLSAPKKCRARFGLDQQN
NWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKA

--------------------------------------------------------------

>98611_98611_20_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000603594_TCF7L2_chr10_114900943_ENST00000538897_length(amino acids)=385AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITG

--------------------------------------------------------------

>98611_98611_21_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000603594_TCF7L2_chr10_114900943_ENST00000543371_length(amino acids)=505AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDANTPKKCRALFGLDRQT
LWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKA

--------------------------------------------------------------

>98611_98611_22_VWA2-TCF7L2_VWA2_chr10_116014807_ENST00000603594_TCF7L2_chr10_114900943_ENST00000545257_length(amino acids)=522AA_BP=87
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNK
VPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFR
HPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK
VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITD
ANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLS

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:/chr10:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VWA2

Q5GFL6

TCF7L2

Q9NQB0

FUNCTION: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000352065315318_332161.0386.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000352065315333_350161.0386.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000352065315520_537161.0386.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000352065315584_619161.0386.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355717413318_332208.0490.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355717413333_350208.0490.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355717413520_537208.0490.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355717413584_619208.0490.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355995415318_332184.0620.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355995415333_350184.0620.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355995415520_537184.0620.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355995415584_619184.0620.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000369397314318_332161.0597.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000369397314333_350161.0597.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000369397314520_537161.0597.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000369397314584_619161.0597.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000534894415318_332184.0495.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000534894415333_350184.0495.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000534894415520_537184.0495.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000534894415584_619184.0495.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000536810414318_332184.0603.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000536810414333_350184.0603.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000536810414520_537184.0603.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000536810414584_619184.0603.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000538897414318_332184.0483.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000538897414333_350184.0483.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000538897414520_537184.0483.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000538897414584_619184.0483.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000543371414318_332184.0603.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000543371414333_350184.0603.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000543371414520_537184.0603.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000543371414584_619184.0603.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000545257415318_332184.0620.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000545257415333_350184.0620.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000545257415520_537184.0620.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000545257415584_619184.0620.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000352065315350_418161.0386.0DNA bindingHMG box
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355717413350_418208.0490.0DNA bindingHMG box
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355995415350_418184.0620.0DNA bindingHMG box
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000369397314350_418161.0597.0DNA bindingHMG box
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000534894415350_418184.0495.0DNA bindingHMG box
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000536810414350_418184.0603.0DNA bindingHMG box
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000538897414350_418184.0483.0DNA bindingHMG box
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000543371414350_418184.0603.0DNA bindingHMG box
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000545257415350_418184.0620.0DNA bindingHMG box
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000352065315425_430161.0386.0MotifNuclear localization signal
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355717413425_430208.0490.0MotifNuclear localization signal
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355995415425_430184.0620.0MotifNuclear localization signal
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000369397314425_430161.0597.0MotifNuclear localization signal
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000534894415425_430184.0495.0MotifNuclear localization signal
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000536810414425_430184.0603.0MotifNuclear localization signal
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000538897414425_430184.0483.0MotifNuclear localization signal
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000543371414425_430184.0603.0MotifNuclear localization signal
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000545257415425_430184.0620.0MotifNuclear localization signal
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000352065315318_350161.0386.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000352065315420_441161.0386.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000352065315459_505161.0386.0RegionNote=Promoter-specific activation domain
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000352065315496_547161.0386.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000352065315574_619161.0386.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355717413318_350208.0490.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355717413420_441208.0490.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355717413459_505208.0490.0RegionNote=Promoter-specific activation domain
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355717413496_547208.0490.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355717413574_619208.0490.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355995415318_350184.0620.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355995415420_441184.0620.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355995415459_505184.0620.0RegionNote=Promoter-specific activation domain
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355995415496_547184.0620.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000355995415574_619184.0620.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000369397314318_350161.0597.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000369397314420_441161.0597.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000369397314459_505161.0597.0RegionNote=Promoter-specific activation domain
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000369397314496_547161.0597.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000369397314574_619161.0597.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000534894415318_350184.0495.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000534894415420_441184.0495.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000534894415459_505184.0495.0RegionNote=Promoter-specific activation domain
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000534894415496_547184.0495.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000534894415574_619184.0495.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000536810414318_350184.0603.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000536810414420_441184.0603.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000536810414459_505184.0603.0RegionNote=Promoter-specific activation domain
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000536810414496_547184.0603.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000536810414574_619184.0603.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000538897414318_350184.0483.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000538897414420_441184.0483.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000538897414459_505184.0483.0RegionNote=Promoter-specific activation domain
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000538897414496_547184.0483.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000538897414574_619184.0483.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000543371414318_350184.0603.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000543371414420_441184.0603.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000543371414459_505184.0603.0RegionNote=Promoter-specific activation domain
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000543371414496_547184.0603.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000543371414574_619184.0603.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000545257415318_350184.0620.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000545257415420_441184.0620.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000545257415459_505184.0620.0RegionNote=Promoter-specific activation domain
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000545257415496_547184.0620.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST00000545257415574_619184.0620.0RegionDisordered

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVWA2chr10:116014807chr10:114900943ENST00000392982414296_33387.0756.0DomainEGF-like 1
HgeneVWA2chr10:116014807chr10:114900943ENST00000392982414343_51787.0756.0DomainVWFA 2
HgeneVWA2chr10:116014807chr10:114900943ENST0000039298241451_22287.0756.0DomainVWFA 1
HgeneVWA2chr10:116014807chr10:114900943ENST00000392982414531_70587.0756.0DomainVWFA 3
HgeneVWA2chr10:116014807chr10:114900943ENST00000392982414712_74887.0756.0DomainEGF-like 2
HgeneVWA2chr10:116014807chr10:114900943ENST00000603594412296_33387.0726.0DomainEGF-like 1
HgeneVWA2chr10:116014807chr10:114900943ENST00000603594412343_51787.0726.0DomainVWFA 2
HgeneVWA2chr10:116014807chr10:114900943ENST0000060359441251_22287.0726.0DomainVWFA 1
HgeneVWA2chr10:116014807chr10:114900943ENST00000603594412531_70587.0726.0DomainVWFA 3
HgeneVWA2chr10:116014807chr10:114900943ENST00000603594412712_74887.0726.0DomainEGF-like 2
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000035206531516_46161.0386.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000035206531547_63161.0386.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000035206531564_91161.0386.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000035571741316_46208.0490.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000035571741347_63208.0490.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000035571741364_91208.0490.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000035599541516_46184.0620.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000035599541547_63184.0620.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000035599541564_91184.0620.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000036939731416_46161.0597.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000036939731447_63161.0597.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000036939731464_91161.0597.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000053489441516_46184.0495.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000053489441547_63184.0495.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000053489441564_91184.0495.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000053681041416_46184.0603.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000053681041447_63184.0603.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000053681041464_91184.0603.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000053889741416_46184.0483.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000053889741447_63184.0483.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000053889741464_91184.0483.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000054337141416_46184.0603.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000054337141447_63184.0603.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000054337141464_91184.0603.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000054525741516_46184.0620.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000054525741547_63184.0620.0Compositional biasPolar residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST0000054525741564_91184.0620.0Compositional biasBasic and acidic residues
TgeneTCF7L2chr10:116014807chr10:114900943ENST000003520653151_53161.0386.0RegionCTNNB1-binding
TgeneTCF7L2chr10:116014807chr10:114900943ENST000003520653151_96161.0386.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST000003557174131_53208.0490.0RegionCTNNB1-binding
TgeneTCF7L2chr10:116014807chr10:114900943ENST000003557174131_96208.0490.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST000003559954151_53184.0620.0RegionCTNNB1-binding
TgeneTCF7L2chr10:116014807chr10:114900943ENST000003559954151_96184.0620.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST000003693973141_53161.0597.0RegionCTNNB1-binding
TgeneTCF7L2chr10:116014807chr10:114900943ENST000003693973141_96161.0597.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST000005348944151_53184.0495.0RegionCTNNB1-binding
TgeneTCF7L2chr10:116014807chr10:114900943ENST000005348944151_96184.0495.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST000005368104141_53184.0603.0RegionCTNNB1-binding
TgeneTCF7L2chr10:116014807chr10:114900943ENST000005368104141_96184.0603.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST000005388974141_53184.0483.0RegionCTNNB1-binding
TgeneTCF7L2chr10:116014807chr10:114900943ENST000005388974141_96184.0483.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST000005433714141_53184.0603.0RegionCTNNB1-binding
TgeneTCF7L2chr10:116014807chr10:114900943ENST000005433714141_96184.0603.0RegionDisordered
TgeneTCF7L2chr10:116014807chr10:114900943ENST000005452574151_53184.0620.0RegionCTNNB1-binding
TgeneTCF7L2chr10:116014807chr10:114900943ENST000005452574151_96184.0620.0RegionDisordered


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (22) >>>22.pdbFusion protein BP residue: 87
CIF file (22) >>>22.cif		VWA2chr10116014807TCF7L2chr10114900943
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAV
DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNKVPVVQHPHHV
HPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSP
191
3D view using mol* of 22 (AA BP:87)
PDB file (23) >>>23.pdbFusion protein BP residue: 87
CIF file (23) >>>23.cif		VWA2chr10116014807TCF7L2chr10114900943
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAV
DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNKVPVVQHPHHV
HPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSP
195
3D view using mol* of 23 (AA BP:87)
PDB file (122) >>>122.pdbFusion protein BP residue: 87
CIF file (122) >>>122.cif		VWA2chr10116014807TCF7L2chr10114900943
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAV
DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNKVPVVQHPHHV
HPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSP
GTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHM
VPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKK
PHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQA
KYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNGEKKSAFA
368
3D view using mol* of 122 (AA BP:87)
PDB file (141) >>>141.pdbFusion protein BP residue: 87
CIF file (141) >>>141.cif		VWA2chr10116014807TCF7L2chr10114900943
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAV
DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNKVPVVQHPHHV
HPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSP
GTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHM
VPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKK
PHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQA
KYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLN
385
3D view using mol* of 141 (AA BP:87)
PDB file (142) >>>142.pdbFusion protein BP residue: 87
CIF file (142) >>>142.cif		VWA2chr10116014807TCF7L2chr10114900943
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAV
DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNKVPVVQHPHHV
HPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSP
GTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHM
VPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKK
PHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQA
KYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLN
385
3D view using mol* of 142 (AA BP:87)
PDB file (156) >>>156.pdbFusion protein BP residue: 87
CIF file (156) >>>156.cif		VWA2chr10116014807TCF7L2chr10114900943
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAV
DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNKVPVVQHPHHV
HPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSP
GTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHM
VPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKK
PHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQA
KYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLN
397
3D view using mol* of 156 (AA BP:87)
PDB file (158) >>>158.pdbFusion protein BP residue: 87
CIF file (158) >>>158.cif		VWA2chr10116014807TCF7L2chr10114900943
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAV
DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNKVPVVQHPHHV
HPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSP
GTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHM
VPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKK
PHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQA
KYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLN
398
3D view using mol* of 158 (AA BP:87)
PDB file (314) >>>314.pdbFusion protein BP residue: 87
CIF file (314) >>>314.cif		VWA2chr10116014807TCF7L2chr10114900943
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAV
DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNKVPVVQHPHHV
HPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSP
GTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHM
VPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKK
PHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQA
KYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDLSAPKKC
RARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSP
NLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKA
SALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGTQPQPLSLV
505
3D view using mol* of 314 (AA BP:87)
PDB file (315) >>>315.pdbFusion protein BP residue: 87
CIF file (315) >>>315.cif		VWA2chr10116014807TCF7L2chr10114900943
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAV
DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNKVPVVQHPHHV
HPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSP
GTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHM
VPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKK
PHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQA
KYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDANTPKKC
RALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSP
NLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKA
SALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGTQPQPLSLV
505
3D view using mol* of 315 (AA BP:87)
PDB file (345) >>>345.pdbFusion protein BP residue: 87
CIF file (345) >>>345.cif		VWA2chr10116014807TCF7L2chr10114900943
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAV
DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNKVPVVQHPHHV
HPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSP
GTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHM
VPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKK
PHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQA
KYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLN
PCLSLPPITDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCL
SPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLS
MMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSL
522
3D view using mol* of 345 (AA BP:87)
PDB file (346) >>>346.pdbFusion protein BP residue: 87
CIF file (346) >>>346.cif		VWA2chr10116014807TCF7L2chr10114900943
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAV
DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERSNKVPVVQHPHHV
HPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSP
GTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHM
VPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKK
PHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQA
KYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLN
PCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCL
SPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLS
MMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSL
522
3D view using mol* of 346 (AA BP:87)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
VWA2_pLDDT.png
all structure
all structure
TCF7L2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
VWA2_TCF7L2_22_pLDDT.png (AA BP:87)
all structure
VWA2_TCF7L2_22_pLDDT_and_active_sites.png (AA BP:87)
all structure
VWA2_TCF7L2_22_violinplot.png (AA BP:87)
all structure
VWA2_TCF7L2_23_pLDDT.png (AA BP:87)
all structure
VWA2_TCF7L2_23_pLDDT_and_active_sites.png (AA BP:87)
all structure
VWA2_TCF7L2_23_violinplot.png (AA BP:87)
all structure
VWA2_TCF7L2_122_PAE.png (AA BP:87)
all structure
VWA2_TCF7L2_122_pLDDT.png (AA BP:87)
all structure
VWA2_TCF7L2_122_pLDDT_and_active_sites.png (AA BP:87)
all structure
VWA2_TCF7L2_122_violinplot.png (AA BP:87)
all structure
VWA2_TCF7L2_141_PAE.png (AA BP:87)
all structure
VWA2_TCF7L2_141_pLDDT.png (AA BP:87)
all structure
VWA2_TCF7L2_141_pLDDT_and_active_sites.png (AA BP:87)
all structure
VWA2_TCF7L2_142_PAE.png (AA BP:87)
all structure
VWA2_TCF7L2_142_pLDDT.png (AA BP:87)
all structure
VWA2_TCF7L2_142_pLDDT_and_active_sites.png (AA BP:87)
all structure
VWA2_TCF7L2_142_violinplot.png (AA BP:87)
all structure
VWA2_TCF7L2_156_PAE.png (AA BP:87)
all structure
VWA2_TCF7L2_156_pLDDT.png (AA BP:87)
all structure
VWA2_TCF7L2_156_pLDDT_and_active_sites.png (AA BP:87)
all structure
VWA2_TCF7L2_156_violinplot.png (AA BP:87)
all structure
VWA2_TCF7L2_158_PAE.png (AA BP:87)
all structure
VWA2_TCF7L2_158_pLDDT.png (AA BP:87)
all structure
VWA2_TCF7L2_158_pLDDT_and_active_sites.png (AA BP:87)
all structure
VWA2_TCF7L2_158_violinplot.png (AA BP:87)
all structure
VWA2_TCF7L2_314_pLDDT.png (AA BP:87)
all structure
VWA2_TCF7L2_314_pLDDT_and_active_sites.png (AA BP:87)
all structure
VWA2_TCF7L2_314_violinplot.png (AA BP:87)
all structure
VWA2_TCF7L2_315_pLDDT.png (AA BP:87)
all structure
VWA2_TCF7L2_315_pLDDT_and_active_sites.png (AA BP:87)
all structure
VWA2_TCF7L2_315_violinplot.png (AA BP:87)
all structure
VWA2_TCF7L2_345_pLDDT.png (AA BP:87)
all structure
VWA2_TCF7L2_345_pLDDT_and_active_sites.png (AA BP:87)
all structure
VWA2_TCF7L2_345_violinplot.png (AA BP:87)
all structure
VWA2_TCF7L2_346_pLDDT.png (AA BP:87)
all structure
VWA2_TCF7L2_346_pLDDT_and_active_sites.png (AA BP:87)
all structure
VWA2_TCF7L2_346_violinplot.png (AA BP:87)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
VWA2_TCF7L2_22.png
all structure
VWA2_TCF7L2_23.png
all structure
VWA2_TCF7L2_122.png
all structure
VWA2_TCF7L2_141.png
all structure
VWA2_TCF7L2_142.png
all structure
VWA2_TCF7L2_156.png
all structure
VWA2_TCF7L2_158.png
all structure
VWA2_TCF7L2_314.png
all structure
VWA2_TCF7L2_315.png
all structure
VWA2_TCF7L2_345.png
all structure
VWA2_TCF7L2_346.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
221.0072141.044795.4170.5430.6730.9010.7480.9180.8141.177Chain A: 47,48,49,50,51,52,53,54,56,67,71,74,75,78
,81,82,83,84,85,87,88,89,90,91,103,104,105,106,107
,108,109,110,111,112,113,114
231.0222011.072742.2520.530.670.8490.7110.8290.8581.127Chain A: 47,48,49,50,51,52,53,54,55,56,71,74,75,78
,81,82,83,84,87,88,89,106,107,108,109,110,111,112,
113,114
1221.0221141.045442.8130.4520.7191.0330.7911.0010.790.506Chain A: 22,23,24,25,26,27,28,29,30,51,52,53,54,55
,56,57,62,66,67,69,70,73,94
1421.0271361.084400.6240.5310.6640.9130.9440.781.211.4Chain A: 56,71,74,75,78,93,94,95,96,97,99,100,101,
102,103,104,105,106,107,108,109,110,111,112,113,11
4
1561.0441071.104336.4830.5840.6780.9220.9190.7451.2331.173Chain A: 54,56,67,71,74,75,78,91,92,93,94,95,96,97
,98,100,101,102,103,104,105,106,107,108,109,110,11
2,114
1581.0441071.104333.3960.580.6780.9150.9280.7441.2471.217Chain A: 54,56,71,74,75,78,91,92,93,94,95,96,97,98
,100,101,102,103,104,105,106,107,108,109,110,111,1
12,114
3141.0431531.11524.4470.5850.6650.8541.0180.7031.4491.426Chain A: 7,10,11,14,15,36,37,38,39,40,41,43,44,45,
46,47,48,49,50,76,77,79,80,81,82,84,87,88,89
3151.0151711.075493.2340.6050.6410.8680.9280.7651.2130.723Chain A: 54,56,71,74,75,78,79,83,84,85,88,89,90,91
,92,93,94,95,97,99,100,101,102,103,104,105,106,107
,108,109,110,111,113,114
3451.0131761.057483.630.5540.6680.9671.0780.8721.2360.899Chain A: 54,56,71,74,75,78,79,81,83,84,85,88,89,90
,91,92,93,94,95,97,101,102,103,104,105,106,107,108
,109,110,112,113,114,115
3461.0211751.065435.2670.510.6780.9261.1240.8641.3020.752Chain A: 52,54,56,67,71,74,75,78,79,81,83,84,85,88
,89,90,91,92,93,94,95,104,105,106,107,108,109

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
VWA2TRAF2, TUBB7P, TCTEX1D2, UBB, KLF15, HSPA8, WDR47, HSPA2, PTPN3, DDX19B, NUDCD3, GET4, GNB2, MARCH7, HERC1, PPP2R5D, TUBB, TUBB8, DDA1, TCP11L1, RECQL4, CPNE7, CAD, STUB1, TANGO6, MTR, CCZ1, WDR73, CBWD1, RIC8B, MISP, TUBA1A,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
VWA2all structure
TCF7L2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to VWA2-TCF7L2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to VWA2-TCF7L2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTCF7L2C0036341Schizophrenia4PSYGENET
TgeneTCF7L2C0011860Diabetes Mellitus, Non-Insulin-Dependent3CTD_human
TgeneTCF7L2C0009402Colorectal Carcinoma2CTD_human;UNIPROT
TgeneTCF7L2C0009404Colorectal Neoplasms2CTD_human
TgeneTCF7L2C0001418Adenocarcinoma1CTD_human
TgeneTCF7L2C0005586Bipolar Disorder1PSYGENET
TgeneTCF7L2C0007102Malignant tumor of colon1CTD_human
TgeneTCF7L2C0007193Cardiomyopathy, Dilated1CTD_human
TgeneTCF7L2C0009375Colonic Neoplasms1CTD_human
TgeneTCF7L2C0010068Coronary heart disease1CTD_human
TgeneTCF7L2C0020507Hyperplasia1CTD_human
TgeneTCF7L2C0036337Schizoaffective Disorder1PSYGENET
TgeneTCF7L2C0087031Juvenile-Onset Still Disease1CTD_human
TgeneTCF7L2C0151744Myocardial Ischemia1CTD_human
TgeneTCF7L2C0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneTCF7L2C0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneTCF7L2C0205643Carcinoma, Cribriform1CTD_human
TgeneTCF7L2C0205644Carcinoma, Granular Cell1CTD_human
TgeneTCF7L2C0205645Adenocarcinoma, Tubular1CTD_human
TgeneTCF7L2C0600519Ventricular Remodeling1CTD_human
TgeneTCF7L2C0600520Left Ventricle Remodeling1CTD_human
TgeneTCF7L2C1449563Cardiomyopathy, Familial Idiopathic1CTD_human
TgeneTCF7L2C1535926Neurodevelopmental Disorders1CTD_human
TgeneTCF7L2C2931456Prostate cancer, familial1CTD_human
TgeneTCF7L2C3495559Juvenile arthritis1CTD_human
TgeneTCF7L2C3714758Juvenile psoriatic arthritis1CTD_human
TgeneTCF7L2C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneTCF7L2C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneTCF7L2C4722327PROSTATE CANCER, HEREDITARY, 11CTD_human