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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:WDR20-LGALS2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: WDR20-LGALS2
FusionPDB ID: 98907
FusionGDB2.0 ID: 98907
HgeneTgene
Gene symbol

WDR20

LGALS2

Gene ID

91833

3958

Gene nameWD repeat domain 20galectin 3
SynonymsDMRCBP35|GAL3|GALBP|GALIG|L31|LGALS2|MAC2
Cytomap

14q32.31

14q22.3

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 20galectin-335 kDa lectinIgE-binding proteinMAC-2 antigenadvanced glycation end-product receptor 3carbohydrate-binding protein 35epididymis secretory sperm binding proteingalactose-specific lectin 3laminin-binding proteinlectin L-29lectin, galacto
Modification date2020031320200322
UniProtAcc.

P05162

Ensembl transtripts involved in fusion geneENST idsENST00000557186, ENST00000499851, 
ENST00000545563, ENST00000299135, 
ENST00000322340, ENST00000335263, 
ENST00000342702, ENST00000424963, 
ENST00000454394, ENST00000556511, 
ENST00000556807, ENST00000558567, 
ENST00000215886, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 7 X 8=6724 X 2 X 4=32
# samples 166
** MAII scorelog2(16/672*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/32*10)=0.906890595608518
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: WDR20 [Title/Abstract] AND LGALS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)WDR20(102606509)-LGALS2(37967938), # samples:3
Anticipated loss of major functional domain due to fusion event.WDR20-LGALS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WDR20-LGALS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WDR20-LGALS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WDR20-LGALS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WDR20-LGALS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLGALS2

GO:0002548

monocyte chemotaxis

10925302

TgeneLGALS2

GO:0030593

neutrophil chemotaxis

10925302

TgeneLGALS2

GO:0031334

positive regulation of protein complex assembly

24846175

TgeneLGALS2

GO:0045806

negative regulation of endocytosis

19706535

TgeneLGALS2

GO:0048245

eosinophil chemotaxis

10925302

TgeneLGALS2

GO:0048246

macrophage chemotaxis

10925302

TgeneLGALS2

GO:0050918

positive chemotaxis

10925302

TgeneLGALS2

GO:0070232

regulation of T cell apoptotic process

8692888

TgeneLGALS2

GO:0071674

mononuclear cell migration

10925302

TgeneLGALS2

GO:0071677

positive regulation of mononuclear cell migration

10925302

TgeneLGALS2

GO:0090280

positive regulation of calcium ion import

10925302

TgeneLGALS2

GO:1903078

positive regulation of protein localization to plasma membrane

24846175

TgeneLGALS2

GO:2001200

positive regulation of dendritic cell differentiation

16116184

TgeneLGALS2

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

22761016


check buttonFusion gene breakpoints across WDR20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LGALS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-A7TD-01AWDR20chr14

102606509

-LGALS2chr22

37967938

-
ChimerDB4LGGTCGA-DU-A7TD-01AWDR20chr14

102606509

+LGALS2chr22

37967938

-
ChimerDB4LGGTCGA-DU-A7TDWDR20chr14

102606509

+LGALS2chr22

37966742

-
ChimerDB4LGGTCGA-DU-A7TDWDR20chr14

102606509

+LGALS2chr22

37967938

-
ChimerDB4LGGTCGA-DU-A7TDWDR20chr14

102661457

+LGALS2chr22

37967938

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000335263WDR20chr14102606509+ENST00000215886LGALS2chr2237967938-73732968721217
ENST00000322340WDR20chr14102606509+ENST00000215886LGALS2chr2237967938-70629837690217
ENST00000342702WDR20chr14102606509+ENST00000215886LGALS2chr2237967938-68828019672217
ENST00000556807WDR20chr14102606509+ENST00000215886LGALS2chr2237967938-68828019672217
ENST00000558567WDR20chr14102606509+ENST00000215886LGALS2chr2237967938-68427615668217
ENST00000299135WDR20chr14102606509+ENST00000215886LGALS2chr2237967938-6702621654217
ENST00000454394WDR20chr14102606509+ENST00000215886LGALS2chr2237967938-66725910651213
ENST00000556511WDR20chr14102606509+ENST00000215886LGALS2chr2237967938-6572490641213
ENST00000335263WDR20chr14102661457+ENST00000215886LGALS2chr2237967938-92051268904278
ENST00000322340WDR20chr14102661457+ENST00000215886LGALS2chr2237967938-88948137873278
ENST00000342702WDR20chr14102661457+ENST00000215886LGALS2chr2237967938-87146319855278
ENST00000558567WDR20chr14102661457+ENST00000215886LGALS2chr2237967938-86745915851278
ENST00000454394WDR20chr14102661457+ENST00000215886LGALS2chr2237967938-85044210834274
ENST00000424963WDR20chr14102606509+ENST00000215886LGALS2chr2237966742-6232983991133

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000335263ENST00000215886WDR20chr14102606509+LGALS2chr2237967938-0.0096798380.99032015
ENST00000322340ENST00000215886WDR20chr14102606509+LGALS2chr2237967938-0.0079036750.9920963
ENST00000342702ENST00000215886WDR20chr14102606509+LGALS2chr2237967938-0.0078175240.99218243
ENST00000556807ENST00000215886WDR20chr14102606509+LGALS2chr2237967938-0.0078175240.99218243
ENST00000558567ENST00000215886WDR20chr14102606509+LGALS2chr2237967938-0.0083757080.9916243
ENST00000299135ENST00000215886WDR20chr14102606509+LGALS2chr2237967938-0.0094935840.9905065
ENST00000454394ENST00000215886WDR20chr14102606509+LGALS2chr2237967938-0.0099893080.9900107
ENST00000556511ENST00000215886WDR20chr14102606509+LGALS2chr2237967938-0.00959250.9904075
ENST00000335263ENST00000215886WDR20chr14102661457+LGALS2chr2237967938-0.0099894440.99001056
ENST00000322340ENST00000215886WDR20chr14102661457+LGALS2chr2237967938-0.0079300760.9920699
ENST00000342702ENST00000215886WDR20chr14102661457+LGALS2chr2237967938-0.0079526930.9920473
ENST00000558567ENST00000215886WDR20chr14102661457+LGALS2chr2237967938-0.0089073210.9910926
ENST00000454394ENST00000215886WDR20chr14102661457+LGALS2chr2237967938-0.0105444180.9894555
ENST00000424963ENST00000215886WDR20chr14102606509+LGALS2chr2237966742-0.165347340.83465266

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>98907_98907_1_WDR20-LGALS2_WDR20_chr14_102606509_ENST00000299135_LGALS2_chr22_37967938_ENST00000215886_length(amino acids)=217AA_BP=87
LLSKMATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKGEL
EVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKV

--------------------------------------------------------------

>98907_98907_2_WDR20-LGALS2_WDR20_chr14_102606509_ENST00000322340_LGALS2_chr22_37967938_ENST00000215886_length(amino acids)=217AA_BP=87
MLSKMATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKGEL
EVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKV

--------------------------------------------------------------

>98907_98907_3_WDR20-LGALS2_WDR20_chr14_102606509_ENST00000335263_LGALS2_chr22_37967938_ENST00000215886_length(amino acids)=217AA_BP=87
MLSKMATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKGEL
EVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKV

--------------------------------------------------------------

>98907_98907_4_WDR20-LGALS2_WDR20_chr14_102606509_ENST00000342702_LGALS2_chr22_37967938_ENST00000215886_length(amino acids)=217AA_BP=87
MLSKMATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKGEL
EVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKV

--------------------------------------------------------------

>98907_98907_5_WDR20-LGALS2_WDR20_chr14_102606509_ENST00000424963_LGALS2_chr22_37966742_ENST00000215886_length(amino acids)=133AA_BP=1
MLPSNELQTMVDSLKRGLKCRFSLSVPWPRLITKLADPLVDIEVQLPAHIEAEAVAVARLVVEVYEGDADRVGSLRVEGHPVGPAVLRVR

--------------------------------------------------------------

>98907_98907_6_WDR20-LGALS2_WDR20_chr14_102606509_ENST00000454394_LGALS2_chr22_37967938_ENST00000215886_length(amino acids)=213AA_BP=83
MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKGELEVKN
MDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPD

--------------------------------------------------------------

>98907_98907_7_WDR20-LGALS2_WDR20_chr14_102606509_ENST00000556511_LGALS2_chr22_37967938_ENST00000215886_length(amino acids)=213AA_BP=83
MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKGELEVKN
MDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPD

--------------------------------------------------------------

>98907_98907_8_WDR20-LGALS2_WDR20_chr14_102606509_ENST00000556807_LGALS2_chr22_37967938_ENST00000215886_length(amino acids)=217AA_BP=87
MLSKMATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKGEL
EVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKV

--------------------------------------------------------------

>98907_98907_9_WDR20-LGALS2_WDR20_chr14_102606509_ENST00000558567_LGALS2_chr22_37967938_ENST00000215886_length(amino acids)=217AA_BP=87
MLSKMATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKGEL
EVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKV

--------------------------------------------------------------

>98907_98907_10_WDR20-LGALS2_WDR20_chr14_102661457_ENST00000322340_LGALS2_chr22_37967938_ENST00000215886_length(amino acids)=278AA_BP=148
MLSKMATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKAAD
LSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEEGELEVKNMDMKPGSTLKITGSIADGTDGFVIN
LGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFN

--------------------------------------------------------------

>98907_98907_11_WDR20-LGALS2_WDR20_chr14_102661457_ENST00000335263_LGALS2_chr22_37967938_ENST00000215886_length(amino acids)=278AA_BP=148
MLSKMATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKAAD
LSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEEGELEVKNMDMKPGSTLKITGSIADGTDGFVIN
LGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFN

--------------------------------------------------------------

>98907_98907_12_WDR20-LGALS2_WDR20_chr14_102661457_ENST00000342702_LGALS2_chr22_37967938_ENST00000215886_length(amino acids)=278AA_BP=148
MLSKMATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKAAD
LSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEEGELEVKNMDMKPGSTLKITGSIADGTDGFVIN
LGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFN

--------------------------------------------------------------

>98907_98907_13_WDR20-LGALS2_WDR20_chr14_102661457_ENST00000454394_LGALS2_chr22_37967938_ENST00000215886_length(amino acids)=274AA_BP=144
MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKAADLSKP
IDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEEGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQG
TDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSF

--------------------------------------------------------------

>98907_98907_14_WDR20-LGALS2_WDR20_chr14_102661457_ENST00000558567_LGALS2_chr22_37967938_ENST00000215886_length(amino acids)=278AA_BP=148
MLSKMATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKAAD
LSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEEGELEVKNMDMKPGSTLKITGSIADGTDGFVIN
LGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFN

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:102606509/chr22:37967938)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LGALS2

P05162

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: This protein binds beta-galactoside. Its physiological function is not yet known.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR20chr14:102661457chr22:37967938ENST00000322340+2494_138144.0196.0RepeatNote=WD 1
HgeneWDR20chr14:102661457chr22:37967938ENST00000335263+2494_138144.0582.0RepeatNote=WD 1
HgeneWDR20chr14:102661457chr22:37967938ENST00000342702+2394_138144.0570.0RepeatNote=WD 1
HgeneWDR20chr14:102661457chr22:37967938ENST00000454394+2494_138144.0601.0RepeatNote=WD 1
TgeneLGALS2chr14:102606509chr22:37967938ENST00000215886044_1312.0133.0DomainGalectin
TgeneLGALS2chr14:102661457chr22:37967938ENST00000215886044_1312.0133.0DomainGalectin
TgeneLGALS2chr14:102606509chr22:37966742ENST000002158861465_7129.666666666666668133.0RegionBeta-galactoside binding
TgeneLGALS2chr14:102606509chr22:37967938ENST000002158860465_712.0133.0RegionBeta-galactoside binding
TgeneLGALS2chr14:102661457chr22:37967938ENST000002158860465_712.0133.0RegionBeta-galactoside binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR20chr14:102606509chr22:37966742ENST00000299135+13139_21083.0640.6666666666666RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37966742ENST00000299135+13211_25283.0640.6666666666666RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37966742ENST00000299135+13253_33183.0640.6666666666666RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37966742ENST00000299135+13332_42683.0640.6666666666666RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37966742ENST00000299135+13427_52383.0640.6666666666666RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37966742ENST00000299135+13524_55983.0640.6666666666666RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37966742ENST00000299135+1394_13883.0640.6666666666666RepeatNote=WD 1
HgeneWDR20chr14:102606509chr22:37966742ENST00000322340+14139_21083.0196.0RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37966742ENST00000322340+14211_25283.0196.0RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37966742ENST00000322340+14253_33183.0196.0RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37966742ENST00000322340+14332_42683.0196.0RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37966742ENST00000322340+14427_52383.0196.0RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37966742ENST00000322340+14524_55983.0196.0RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37966742ENST00000322340+1494_13883.0196.0RepeatNote=WD 1
HgeneWDR20chr14:102606509chr22:37966742ENST00000335263+14139_21083.0582.0RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37966742ENST00000335263+14211_25283.0582.0RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37966742ENST00000335263+14253_33183.0582.0RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37966742ENST00000335263+14332_42683.0582.0RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37966742ENST00000335263+14427_52383.0582.0RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37966742ENST00000335263+14524_55983.0582.0RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37966742ENST00000335263+1494_13883.0582.0RepeatNote=WD 1
HgeneWDR20chr14:102606509chr22:37966742ENST00000342702+13139_21083.0570.0RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37966742ENST00000342702+13211_25283.0570.0RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37966742ENST00000342702+13253_33183.0570.0RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37966742ENST00000342702+13332_42683.0570.0RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37966742ENST00000342702+13427_52383.0570.0RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37966742ENST00000342702+13524_55983.0570.0RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37966742ENST00000342702+1394_13883.0570.0RepeatNote=WD 1
HgeneWDR20chr14:102606509chr22:37966742ENST00000454394+14139_21083.0601.0RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37966742ENST00000454394+14211_25283.0601.0RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37966742ENST00000454394+14253_33183.0601.0RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37966742ENST00000454394+14332_42683.0601.0RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37966742ENST00000454394+14427_52383.0601.0RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37966742ENST00000454394+14524_55983.0601.0RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37966742ENST00000454394+1494_13883.0601.0RepeatNote=WD 1
HgeneWDR20chr14:102606509chr22:37966742ENST00000556511+12139_21083.0509.0RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37966742ENST00000556511+12211_25283.0509.0RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37966742ENST00000556511+12253_33183.0509.0RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37966742ENST00000556511+12332_42683.0509.0RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37966742ENST00000556511+12427_52383.0509.0RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37966742ENST00000556511+12524_55983.0509.0RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37966742ENST00000556511+1294_13883.0509.0RepeatNote=WD 1
HgeneWDR20chr14:102606509chr22:37966742ENST00000556807+13139_21083.0521.0RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37966742ENST00000556807+13211_25283.0521.0RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37966742ENST00000556807+13253_33183.0521.0RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37966742ENST00000556807+13332_42683.0521.0RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37966742ENST00000556807+13427_52383.0521.0RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37966742ENST00000556807+13524_55983.0521.0RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37966742ENST00000556807+1394_13883.0521.0RepeatNote=WD 1
HgeneWDR20chr14:102606509chr22:37967938ENST00000299135+13139_21083.0640.6666666666666RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37967938ENST00000299135+13211_25283.0640.6666666666666RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37967938ENST00000299135+13253_33183.0640.6666666666666RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37967938ENST00000299135+13332_42683.0640.6666666666666RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37967938ENST00000299135+13427_52383.0640.6666666666666RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37967938ENST00000299135+13524_55983.0640.6666666666666RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37967938ENST00000299135+1394_13883.0640.6666666666666RepeatNote=WD 1
HgeneWDR20chr14:102606509chr22:37967938ENST00000322340+14139_21083.0196.0RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37967938ENST00000322340+14211_25283.0196.0RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37967938ENST00000322340+14253_33183.0196.0RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37967938ENST00000322340+14332_42683.0196.0RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37967938ENST00000322340+14427_52383.0196.0RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37967938ENST00000322340+14524_55983.0196.0RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37967938ENST00000322340+1494_13883.0196.0RepeatNote=WD 1
HgeneWDR20chr14:102606509chr22:37967938ENST00000335263+14139_21083.0582.0RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37967938ENST00000335263+14211_25283.0582.0RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37967938ENST00000335263+14253_33183.0582.0RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37967938ENST00000335263+14332_42683.0582.0RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37967938ENST00000335263+14427_52383.0582.0RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37967938ENST00000335263+14524_55983.0582.0RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37967938ENST00000335263+1494_13883.0582.0RepeatNote=WD 1
HgeneWDR20chr14:102606509chr22:37967938ENST00000342702+13139_21083.0570.0RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37967938ENST00000342702+13211_25283.0570.0RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37967938ENST00000342702+13253_33183.0570.0RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37967938ENST00000342702+13332_42683.0570.0RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37967938ENST00000342702+13427_52383.0570.0RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37967938ENST00000342702+13524_55983.0570.0RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37967938ENST00000342702+1394_13883.0570.0RepeatNote=WD 1
HgeneWDR20chr14:102606509chr22:37967938ENST00000454394+14139_21083.0601.0RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37967938ENST00000454394+14211_25283.0601.0RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37967938ENST00000454394+14253_33183.0601.0RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37967938ENST00000454394+14332_42683.0601.0RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37967938ENST00000454394+14427_52383.0601.0RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37967938ENST00000454394+14524_55983.0601.0RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37967938ENST00000454394+1494_13883.0601.0RepeatNote=WD 1
HgeneWDR20chr14:102606509chr22:37967938ENST00000556511+12139_21083.0509.0RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37967938ENST00000556511+12211_25283.0509.0RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37967938ENST00000556511+12253_33183.0509.0RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37967938ENST00000556511+12332_42683.0509.0RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37967938ENST00000556511+12427_52383.0509.0RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37967938ENST00000556511+12524_55983.0509.0RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37967938ENST00000556511+1294_13883.0509.0RepeatNote=WD 1
HgeneWDR20chr14:102606509chr22:37967938ENST00000556807+13139_21083.0521.0RepeatNote=WD 2
HgeneWDR20chr14:102606509chr22:37967938ENST00000556807+13211_25283.0521.0RepeatNote=WD 3
HgeneWDR20chr14:102606509chr22:37967938ENST00000556807+13253_33183.0521.0RepeatNote=WD 4
HgeneWDR20chr14:102606509chr22:37967938ENST00000556807+13332_42683.0521.0RepeatNote=WD 5
HgeneWDR20chr14:102606509chr22:37967938ENST00000556807+13427_52383.0521.0RepeatNote=WD 6
HgeneWDR20chr14:102606509chr22:37967938ENST00000556807+13524_55983.0521.0RepeatNote=WD 7
HgeneWDR20chr14:102606509chr22:37967938ENST00000556807+1394_13883.0521.0RepeatNote=WD 1
HgeneWDR20chr14:102661457chr22:37967938ENST00000299135+13139_2100640.6666666666666RepeatNote=WD 2
HgeneWDR20chr14:102661457chr22:37967938ENST00000299135+13211_2520640.6666666666666RepeatNote=WD 3
HgeneWDR20chr14:102661457chr22:37967938ENST00000299135+13253_3310640.6666666666666RepeatNote=WD 4
HgeneWDR20chr14:102661457chr22:37967938ENST00000299135+13332_4260640.6666666666666RepeatNote=WD 5
HgeneWDR20chr14:102661457chr22:37967938ENST00000299135+13427_5230640.6666666666666RepeatNote=WD 6
HgeneWDR20chr14:102661457chr22:37967938ENST00000299135+13524_5590640.6666666666666RepeatNote=WD 7
HgeneWDR20chr14:102661457chr22:37967938ENST00000299135+1394_1380640.6666666666666RepeatNote=WD 1
HgeneWDR20chr14:102661457chr22:37967938ENST00000322340+24139_210144.0196.0RepeatNote=WD 2
HgeneWDR20chr14:102661457chr22:37967938ENST00000322340+24211_252144.0196.0RepeatNote=WD 3
HgeneWDR20chr14:102661457chr22:37967938ENST00000322340+24253_331144.0196.0RepeatNote=WD 4
HgeneWDR20chr14:102661457chr22:37967938ENST00000322340+24332_426144.0196.0RepeatNote=WD 5
HgeneWDR20chr14:102661457chr22:37967938ENST00000322340+24427_523144.0196.0RepeatNote=WD 6
HgeneWDR20chr14:102661457chr22:37967938ENST00000322340+24524_559144.0196.0RepeatNote=WD 7
HgeneWDR20chr14:102661457chr22:37967938ENST00000335263+24139_210144.0582.0RepeatNote=WD 2
HgeneWDR20chr14:102661457chr22:37967938ENST00000335263+24211_252144.0582.0RepeatNote=WD 3
HgeneWDR20chr14:102661457chr22:37967938ENST00000335263+24253_331144.0582.0RepeatNote=WD 4
HgeneWDR20chr14:102661457chr22:37967938ENST00000335263+24332_426144.0582.0RepeatNote=WD 5
HgeneWDR20chr14:102661457chr22:37967938ENST00000335263+24427_523144.0582.0RepeatNote=WD 6
HgeneWDR20chr14:102661457chr22:37967938ENST00000335263+24524_559144.0582.0RepeatNote=WD 7
HgeneWDR20chr14:102661457chr22:37967938ENST00000342702+23139_210144.0570.0RepeatNote=WD 2
HgeneWDR20chr14:102661457chr22:37967938ENST00000342702+23211_252144.0570.0RepeatNote=WD 3
HgeneWDR20chr14:102661457chr22:37967938ENST00000342702+23253_331144.0570.0RepeatNote=WD 4
HgeneWDR20chr14:102661457chr22:37967938ENST00000342702+23332_426144.0570.0RepeatNote=WD 5
HgeneWDR20chr14:102661457chr22:37967938ENST00000342702+23427_523144.0570.0RepeatNote=WD 6
HgeneWDR20chr14:102661457chr22:37967938ENST00000342702+23524_559144.0570.0RepeatNote=WD 7
HgeneWDR20chr14:102661457chr22:37967938ENST00000454394+24139_210144.0601.0RepeatNote=WD 2
HgeneWDR20chr14:102661457chr22:37967938ENST00000454394+24211_252144.0601.0RepeatNote=WD 3
HgeneWDR20chr14:102661457chr22:37967938ENST00000454394+24253_331144.0601.0RepeatNote=WD 4
HgeneWDR20chr14:102661457chr22:37967938ENST00000454394+24332_426144.0601.0RepeatNote=WD 5
HgeneWDR20chr14:102661457chr22:37967938ENST00000454394+24427_523144.0601.0RepeatNote=WD 6
HgeneWDR20chr14:102661457chr22:37967938ENST00000454394+24524_559144.0601.0RepeatNote=WD 7
HgeneWDR20chr14:102661457chr22:37967938ENST00000556511+12139_2100.0509.0RepeatNote=WD 2
HgeneWDR20chr14:102661457chr22:37967938ENST00000556511+12211_2520.0509.0RepeatNote=WD 3
HgeneWDR20chr14:102661457chr22:37967938ENST00000556511+12253_3310.0509.0RepeatNote=WD 4
HgeneWDR20chr14:102661457chr22:37967938ENST00000556511+12332_4260.0509.0RepeatNote=WD 5
HgeneWDR20chr14:102661457chr22:37967938ENST00000556511+12427_5230.0509.0RepeatNote=WD 6
HgeneWDR20chr14:102661457chr22:37967938ENST00000556511+12524_5590.0509.0RepeatNote=WD 7
HgeneWDR20chr14:102661457chr22:37967938ENST00000556511+1294_1380.0509.0RepeatNote=WD 1
HgeneWDR20chr14:102661457chr22:37967938ENST00000556807+13139_2100521.0RepeatNote=WD 2
HgeneWDR20chr14:102661457chr22:37967938ENST00000556807+13211_2520521.0RepeatNote=WD 3
HgeneWDR20chr14:102661457chr22:37967938ENST00000556807+13253_3310521.0RepeatNote=WD 4
HgeneWDR20chr14:102661457chr22:37967938ENST00000556807+13332_4260521.0RepeatNote=WD 5
HgeneWDR20chr14:102661457chr22:37967938ENST00000556807+13427_5230521.0RepeatNote=WD 6
HgeneWDR20chr14:102661457chr22:37967938ENST00000556807+13524_5590521.0RepeatNote=WD 7
HgeneWDR20chr14:102661457chr22:37967938ENST00000556807+1394_1380521.0RepeatNote=WD 1
TgeneLGALS2chr14:102606509chr22:37966742ENST00000215886144_13129.666666666666668133.0DomainGalectin


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>319_WDR20_102606509_LGALS2_37967938_ranked_0.pdbWDR20102606509102606509ENST00000215886LGALS2chr2237967938-
MLSKMATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKGEL
EVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKV
217


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
WDR20_pLDDT.png
all structure
all structure
LGALS2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
WDR20
LGALS2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to WDR20-LGALS2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to WDR20-LGALS2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource