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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:WHSC1-GSDMB

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: WHSC1-GSDMB
FusionPDB ID: 99189
FusionGDB2.0 ID: 99189
HgeneTgene
Gene symbol

WHSC1

GSDMB

Gene ID

7468

55876

Gene namenuclear receptor binding SET domain protein 2gasdermin B
SynonymsKMT3F|KMT3G|MMSET|REIIBP|TRX5|WHS|WHSC1GSDMB-1|GSDML|PP4052|PRO2521
Cytomap

4p16.3

17q21.1

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase NSD2IL5 promoter REII region-binding proteinWolf-Hirschhorn syndrome candidate 1multiple myeloma SET domain containing protein type IIInuclear SET domain-containing protein 2probable histone-lysine N-methyltransferagasdermin-Bgasdermin-like proteingasderminB-1
Modification date2020032920200313
UniProtAcc.

Q8TAX9

Ensembl transtripts involved in fusion geneENST idsENST00000482415, ENST00000382888, 
ENST00000382891, ENST00000382892, 
ENST00000382895, ENST00000508803, 
ENST00000398261, ENST00000420906, 
ENST00000436793, ENST00000503128, 
ENST00000514045, 		ENST00000309481, 
ENST00000360317, ENST00000394175, 
ENST00000394179, ENST00000418519, 
ENST00000520542, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score22 X 18 X 13=514812 X 13 X 9=1404
# samples 2715
** MAII scorelog2(27/5148*10)=-4.25298074116987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1404*10)=-3.22650852980868
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: WHSC1 [Title/Abstract] AND GSDMB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)WHSC1(1957915)-GSDMB(38068750), # samples:3
Anticipated loss of major functional domain due to fusion event.WHSC1-GSDMB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WHSC1-GSDMB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WHSC1-GSDMB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WHSC1-GSDMB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across WHSC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GSDMB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-38-4630-01AWHSC1chr4

1957915

-GSDMBchr17

38068750

-
ChimerDB4LUADTCGA-38-4630-01AWHSC1chr4

1957915

+GSDMBchr17

38068750

-
ChimerDB4LUADTCGA-38-4630WHSC1chr4

1957915

+GSDMBchr17

38068750

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000508803WHSC1chr41957915+ENST00000360317GSDMBchr1738068750-4262302913940441301
ENST00000508803WHSC1chr41957915+ENST00000394175GSDMBchr1738068750-4196302913939781279
ENST00000508803WHSC1chr41957915+ENST00000309481GSDMBchr1738068750-4223302913940051288
ENST00000508803WHSC1chr41957915+ENST00000520542GSDMBchr1738068750-4233302913940171292
ENST00000508803WHSC1chr41957915+ENST00000418519GSDMBchr1738068750-4260302913940441301
ENST00000508803WHSC1chr41957915+ENST00000394179GSDMBchr1738068750-4245302913940291296
ENST00000382892WHSC1chr41957915+ENST00000360317GSDMBchr1738068750-4428319530542101301
ENST00000382892WHSC1chr41957915+ENST00000394175GSDMBchr1738068750-4362319530541441279
ENST00000382892WHSC1chr41957915+ENST00000309481GSDMBchr1738068750-4389319530541711288
ENST00000382892WHSC1chr41957915+ENST00000520542GSDMBchr1738068750-4399319530541831292
ENST00000382892WHSC1chr41957915+ENST00000418519GSDMBchr1738068750-4426319530542101301
ENST00000382892WHSC1chr41957915+ENST00000394179GSDMBchr1738068750-4411319530541951296
ENST00000382891WHSC1chr41957915+ENST00000360317GSDMBchr1738068750-4253302013040351301
ENST00000382891WHSC1chr41957915+ENST00000394175GSDMBchr1738068750-4187302013039691279
ENST00000382891WHSC1chr41957915+ENST00000309481GSDMBchr1738068750-4214302013039961288
ENST00000382891WHSC1chr41957915+ENST00000520542GSDMBchr1738068750-4224302013040081292
ENST00000382891WHSC1chr41957915+ENST00000418519GSDMBchr1738068750-4251302013040351301
ENST00000382891WHSC1chr41957915+ENST00000394179GSDMBchr1738068750-4236302013040201296
ENST00000382895WHSC1chr41957915+ENST00000360317GSDMBchr1738068750-4545331242243271301
ENST00000382895WHSC1chr41957915+ENST00000394175GSDMBchr1738068750-4479331242242611279
ENST00000382895WHSC1chr41957915+ENST00000309481GSDMBchr1738068750-4506331242242881288
ENST00000382895WHSC1chr41957915+ENST00000520542GSDMBchr1738068750-4516331242243001292
ENST00000382895WHSC1chr41957915+ENST00000418519GSDMBchr1738068750-4543331242243271301
ENST00000382895WHSC1chr41957915+ENST00000394179GSDMBchr1738068750-4528331242243121296
ENST00000382888WHSC1chr41957915+ENST00000360317GSDMBchr1738068750-267614435152458647
ENST00000382888WHSC1chr41957915+ENST00000394175GSDMBchr1738068750-261014435152392625
ENST00000382888WHSC1chr41957915+ENST00000309481GSDMBchr1738068750-263714435152419634
ENST00000382888WHSC1chr41957915+ENST00000520542GSDMBchr1738068750-264714435152431638
ENST00000382888WHSC1chr41957915+ENST00000418519GSDMBchr1738068750-267414435152458647
ENST00000382888WHSC1chr41957915+ENST00000394179GSDMBchr1738068750-265914435152443642

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000508803ENST00000360317WHSC1chr41957915+GSDMBchr1738068750-0.0008487010.99915135
ENST00000508803ENST00000394175WHSC1chr41957915+GSDMBchr1738068750-0.0007283990.9992716
ENST00000508803ENST00000309481WHSC1chr41957915+GSDMBchr1738068750-0.000777890.99922216
ENST00000508803ENST00000520542WHSC1chr41957915+GSDMBchr1738068750-0.0006528160.99934715
ENST00000508803ENST00000418519WHSC1chr41957915+GSDMBchr1738068750-0.0008599610.99914
ENST00000508803ENST00000394179WHSC1chr41957915+GSDMBchr1738068750-0.0004553140.9995447
ENST00000382892ENST00000360317WHSC1chr41957915+GSDMBchr1738068750-0.0010166290.9989833
ENST00000382892ENST00000394175WHSC1chr41957915+GSDMBchr1738068750-0.0008850690.99911493
ENST00000382892ENST00000309481WHSC1chr41957915+GSDMBchr1738068750-0.0009487330.9990513
ENST00000382892ENST00000520542WHSC1chr41957915+GSDMBchr1738068750-0.000799810.99920017
ENST00000382892ENST00000418519WHSC1chr41957915+GSDMBchr1738068750-0.001030870.9989692
ENST00000382892ENST00000394179WHSC1chr41957915+GSDMBchr1738068750-0.0005588390.9994412
ENST00000382891ENST00000360317WHSC1chr41957915+GSDMBchr1738068750-0.000734550.9992655
ENST00000382891ENST00000394175WHSC1chr41957915+GSDMBchr1738068750-0.0006276930.9993723
ENST00000382891ENST00000309481WHSC1chr41957915+GSDMBchr1738068750-0.0006733460.9993267
ENST00000382891ENST00000520542WHSC1chr41957915+GSDMBchr1738068750-0.0005618370.9994381
ENST00000382891ENST00000418519WHSC1chr41957915+GSDMBchr1738068750-0.0007440680.99925596
ENST00000382891ENST00000394179WHSC1chr41957915+GSDMBchr1738068750-0.0003934420.99960655
ENST00000382895ENST00000360317WHSC1chr41957915+GSDMBchr1738068750-0.001178650.9988213
ENST00000382895ENST00000394175WHSC1chr41957915+GSDMBchr1738068750-0.0010220890.9989779
ENST00000382895ENST00000309481WHSC1chr41957915+GSDMBchr1738068750-0.0010925510.99890745
ENST00000382895ENST00000520542WHSC1chr41957915+GSDMBchr1738068750-0.0009209640.999079
ENST00000382895ENST00000418519WHSC1chr41957915+GSDMBchr1738068750-0.001194740.9988053
ENST00000382895ENST00000394179WHSC1chr41957915+GSDMBchr1738068750-0.0006433340.9993567
ENST00000382888ENST00000360317WHSC1chr41957915+GSDMBchr1738068750-0.0064909020.9935091
ENST00000382888ENST00000394175WHSC1chr41957915+GSDMBchr1738068750-0.0075225980.9924775
ENST00000382888ENST00000309481WHSC1chr41957915+GSDMBchr1738068750-0.0058570190.99414295
ENST00000382888ENST00000520542WHSC1chr41957915+GSDMBchr1738068750-0.0086513930.9913487
ENST00000382888ENST00000418519WHSC1chr41957915+GSDMBchr1738068750-0.0066357110.99336433
ENST00000382888ENST00000394179WHSC1chr41957915+GSDMBchr1738068750-0.0071345460.99286544

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99189_99189_1_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382888_GSDMB_chr17_38068750_ENST00000309481_length(amino acids)=634AA_BP=309
MMAGSFCWRMLGLVSKVGNRARCFSSMAASEEELLDFSGSELQFNSCSLHLSLHPFFNFLLGIHSCFVCKESKTDVKRCVVTQCGKFYHE
ACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNV
SWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVF
FFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQY
LATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKET
MKKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNA
AGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCALYVVVSILLELAEGPT

--------------------------------------------------------------

>99189_99189_2_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382888_GSDMB_chr17_38068750_ENST00000360317_length(amino acids)=647AA_BP=309
MMAGSFCWRMLGLVSKVGNRARCFSSMAASEEELLDFSGSELQFNSCSLHLSLHPFFNFLLGIHSCFVCKESKTDVKRCVVTQCGKFYHE
ACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNV
SWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVF
FFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQY
LATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKET
MNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHME
DPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCALYV

--------------------------------------------------------------

>99189_99189_3_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382888_GSDMB_chr17_38068750_ENST00000394175_length(amino acids)=625AA_BP=309
MMAGSFCWRMLGLVSKVGNRARCFSSMAASEEELLDFSGSELQFNSCSLHLSLHPFFNFLLGIHSCFVCKESKTDVKRCVVTQCGKFYHE
ACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNV
SWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVF
FFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQY
LATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKET
MRKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARA

--------------------------------------------------------------

>99189_99189_4_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382888_GSDMB_chr17_38068750_ENST00000394179_length(amino acids)=642AA_BP=309
MMAGSFCWRMLGLVSKVGNRARCFSSMAASEEELLDFSGSELQFNSCSLHLSLHPFFNFLLGIHSCFVCKESKTDVKRCVVTQCGKFYHE
ACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNV
SWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVF
FFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQY
LATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKET
MSAGLDIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKP
LLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCALYVVVSIL

--------------------------------------------------------------

>99189_99189_5_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382888_GSDMB_chr17_38068750_ENST00000418519_length(amino acids)=647AA_BP=309
MMAGSFCWRMLGLVSKVGNRARCFSSMAASEEELLDFSGSELQFNSCSLHLSLHPFFNFLLGIHSCFVCKESKTDVKRCVVTQCGKFYHE
ACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNV
SWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVF
FFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQY
LATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKET
MNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHME
DPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCALYV

--------------------------------------------------------------

>99189_99189_6_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382888_GSDMB_chr17_38068750_ENST00000520542_length(amino acids)=638AA_BP=309
MMAGSFCWRMLGLVSKVGNRARCFSSMAASEEELLDFSGSELQFNSCSLHLSLHPFFNFLLGIHSCFVCKESKTDVKRCVVTQCGKFYHE
ACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNV
SWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVF
FFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQY
LATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKET
MNIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSS
LFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCALYVVVSILLELA

--------------------------------------------------------------

>99189_99189_7_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382891_GSDMB_chr17_38068750_ENST00000309481_length(amino acids)=1288AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMKKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVS
EVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYD

--------------------------------------------------------------

>99189_99189_8_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382891_GSDMB_chr17_38068750_ENST00000360317_length(amino acids)=1301AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLG
KEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNW

--------------------------------------------------------------

>99189_99189_9_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382891_GSDMB_chr17_38068750_ENST00000394175_length(amino acids)=1279AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMRKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELH
MEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCAL

--------------------------------------------------------------

>99189_99189_10_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382891_GSDMB_chr17_38068750_ENST00000394179_length(amino acids)=1296AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMSAGLDIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIR
QDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELAS

--------------------------------------------------------------

>99189_99189_11_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382891_GSDMB_chr17_38068750_ENST00000418519_length(amino acids)=1301AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLG
KEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNW

--------------------------------------------------------------

>99189_99189_12_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382891_GSDMB_chr17_38068750_ENST00000520542_length(amino acids)=1292AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLE
QRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPD

--------------------------------------------------------------

>99189_99189_13_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382892_GSDMB_chr17_38068750_ENST00000309481_length(amino acids)=1288AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMKKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVS
EVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYD

--------------------------------------------------------------

>99189_99189_14_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382892_GSDMB_chr17_38068750_ENST00000360317_length(amino acids)=1301AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLG
KEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNW

--------------------------------------------------------------

>99189_99189_15_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382892_GSDMB_chr17_38068750_ENST00000394175_length(amino acids)=1279AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMRKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELH
MEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCAL

--------------------------------------------------------------

>99189_99189_16_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382892_GSDMB_chr17_38068750_ENST00000394179_length(amino acids)=1296AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMSAGLDIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIR
QDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELAS

--------------------------------------------------------------

>99189_99189_17_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382892_GSDMB_chr17_38068750_ENST00000418519_length(amino acids)=1301AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLG
KEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNW

--------------------------------------------------------------

>99189_99189_18_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382892_GSDMB_chr17_38068750_ENST00000520542_length(amino acids)=1292AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLE
QRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPD

--------------------------------------------------------------

>99189_99189_19_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382895_GSDMB_chr17_38068750_ENST00000309481_length(amino acids)=1288AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMKKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVS
EVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYD

--------------------------------------------------------------

>99189_99189_20_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382895_GSDMB_chr17_38068750_ENST00000360317_length(amino acids)=1301AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLG
KEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNW

--------------------------------------------------------------

>99189_99189_21_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382895_GSDMB_chr17_38068750_ENST00000394175_length(amino acids)=1279AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMRKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELH
MEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCAL

--------------------------------------------------------------

>99189_99189_22_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382895_GSDMB_chr17_38068750_ENST00000394179_length(amino acids)=1296AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMSAGLDIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIR
QDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELAS

--------------------------------------------------------------

>99189_99189_23_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382895_GSDMB_chr17_38068750_ENST00000418519_length(amino acids)=1301AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLG
KEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNW

--------------------------------------------------------------

>99189_99189_24_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000382895_GSDMB_chr17_38068750_ENST00000520542_length(amino acids)=1292AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLE
QRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPD

--------------------------------------------------------------

>99189_99189_25_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000508803_GSDMB_chr17_38068750_ENST00000309481_length(amino acids)=1288AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMKKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVS
EVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYD

--------------------------------------------------------------

>99189_99189_26_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000508803_GSDMB_chr17_38068750_ENST00000360317_length(amino acids)=1301AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLG
KEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNW

--------------------------------------------------------------

>99189_99189_27_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000508803_GSDMB_chr17_38068750_ENST00000394175_length(amino acids)=1279AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMRKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELH
MEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCAL

--------------------------------------------------------------

>99189_99189_28_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000508803_GSDMB_chr17_38068750_ENST00000394179_length(amino acids)=1296AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMSAGLDIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIR
QDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELAS

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>99189_99189_29_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000508803_GSDMB_chr17_38068750_ENST00000418519_length(amino acids)=1301AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLG
KEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNW

--------------------------------------------------------------

>99189_99189_30_WHSC1-GSDMB_WHSC1_chr4_1957915_ENST00000508803_GSDMB_chr17_38068750_ENST00000520542_length(amino acids)=1292AA_BP=963
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNP
QVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVS
MPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTE
DAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE
VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC
FVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA
SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE
VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNGQKAEFQILDNVDSTGELIVRLPKEIT
ISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQR
EVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLE
QRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPD

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:1957915/chr17:38068750)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GSDMB

Q8TAX9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: [Gasdermin-B]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death (PubMed:32299851). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-B, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:32299851). {ECO:0000269|PubMed:32299851}.; FUNCTION: [Gasdermin-B, N-terminal]: Pore-forming protein produced by cleavage by granzyme A (GZMA), which causes membrane permeabilization and pyroptosis in target cells of cytotoxic T and natural killer (NK) cells (PubMed:27281216, PubMed:32299851). Key downstream mediator of granzyme-mediated cell death: (1) granzyme A (GZMA), delivered to target cells from cytotoxic T- and NK-cells, (2) specifically cleaves Gasdermin-B to generate this form (PubMed:32299851). After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:32299851). Binds to membrane inner leaflet lipids, such as phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, and more weakly to phosphatidic acid (PubMed:28154144). Also binds sufatide, a component of the apical membrane of epithelial cells (PubMed:28154144). {ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:28154144, ECO:0000269|PubMed:32299851}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382891+1522453_521960.33333333333341366.0DNA bindingHMG box
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382892+1623453_521960.33333333333341366.0DNA bindingHMG box
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382895+1724453_521960.33333333333341366.0DNA bindingHMG box
HgeneWHSC1chr4:1957915chr17:38068750ENST00000508803+1522453_521960.33333333333341366.0DNA bindingHMG box
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382888+512222_286308.3333333333333714.0DomainPWWP 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382891+1522222_286960.33333333333341366.0DomainPWWP 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382891+1522880_942960.33333333333341366.0DomainPWWP 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382892+1623222_286960.33333333333341366.0DomainPWWP 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382892+1623880_942960.33333333333341366.0DomainPWWP 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382895+1724222_286960.33333333333341366.0DomainPWWP 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382895+1724880_942960.33333333333341366.0DomainPWWP 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000508803+1522222_286960.33333333333341366.0DomainPWWP 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000508803+1522880_942960.33333333333341366.0DomainPWWP 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382891+1522667_713960.33333333333341366.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382891+1522714_770960.33333333333341366.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382891+1522831_875960.33333333333341366.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382892+1623667_713960.33333333333341366.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382892+1623714_770960.33333333333341366.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382892+1623831_875960.33333333333341366.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382895+1724667_713960.33333333333341366.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382895+1724714_770960.33333333333341366.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382895+1724831_875960.33333333333341366.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1957915chr17:38068750ENST00000508803+1522667_713960.33333333333341366.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000508803+1522714_770960.33333333333341366.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000508803+1522831_875960.33333333333341366.0Zinc fingerPHD-type 3
TgeneGSDMBchr4:1957915chr17:38068750ENST00000309481110243_27178.33333333333333404.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr4:1957915chr17:38068750ENST00000360317010243_27178.33333333333333417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr4:1957915chr17:38068750ENST0000039417508243_27178.33333333333333395.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr4:1957915chr17:38068750ENST00000394179110243_27178.33333333333333412.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr4:1957915chr17:38068750ENST00000418519111243_27178.33333333333333417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr4:1957915chr17:38068750ENST00000520542110243_27178.33333333333333408.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382888+512453_521308.3333333333333714.0DNA bindingHMG box
HgeneWHSC1chr4:1957915chr17:38068750ENST00000398261+19453_5210648.0DNA bindingHMG box
HgeneWHSC1chr4:1957915chr17:38068750ENST00000420906+111453_5210630.0DNA bindingHMG box
HgeneWHSC1chr4:1957915chr17:38068750ENST00000436793+16453_5210274.0DNA bindingHMG box
HgeneWHSC1chr4:1957915chr17:38068750ENST00000503128+110453_5210648.0DNA bindingHMG box
HgeneWHSC1chr4:1957915chr17:38068750ENST00000514045+19453_5210630.0DNA bindingHMG box
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382888+5121011_1061308.3333333333333714.0DomainAWS
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382888+5121063_1180308.3333333333333714.0DomainSET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382888+5121187_1203308.3333333333333714.0DomainPost-SET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382888+512880_942308.3333333333333714.0DomainPWWP 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382891+15221011_1061960.33333333333341366.0DomainAWS
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382891+15221063_1180960.33333333333341366.0DomainSET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382891+15221187_1203960.33333333333341366.0DomainPost-SET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382892+16231011_1061960.33333333333341366.0DomainAWS
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382892+16231063_1180960.33333333333341366.0DomainSET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382892+16231187_1203960.33333333333341366.0DomainPost-SET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382895+17241011_1061960.33333333333341366.0DomainAWS
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382895+17241063_1180960.33333333333341366.0DomainSET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382895+17241187_1203960.33333333333341366.0DomainPost-SET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000398261+191011_10610648.0DomainAWS
HgeneWHSC1chr4:1957915chr17:38068750ENST00000398261+191063_11800648.0DomainSET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000398261+191187_12030648.0DomainPost-SET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000398261+19222_2860648.0DomainPWWP 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000398261+19880_9420648.0DomainPWWP 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000420906+1111011_10610630.0DomainAWS
HgeneWHSC1chr4:1957915chr17:38068750ENST00000420906+1111063_11800630.0DomainSET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000420906+1111187_12030630.0DomainPost-SET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000420906+111222_2860630.0DomainPWWP 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000420906+111880_9420630.0DomainPWWP 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000436793+161011_10610274.0DomainAWS
HgeneWHSC1chr4:1957915chr17:38068750ENST00000436793+161063_11800274.0DomainSET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000436793+161187_12030274.0DomainPost-SET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000436793+16222_2860274.0DomainPWWP 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000436793+16880_9420274.0DomainPWWP 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000503128+1101011_10610648.0DomainAWS
HgeneWHSC1chr4:1957915chr17:38068750ENST00000503128+1101063_11800648.0DomainSET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000503128+1101187_12030648.0DomainPost-SET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000503128+110222_2860648.0DomainPWWP 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000503128+110880_9420648.0DomainPWWP 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000508803+15221011_1061960.33333333333341366.0DomainAWS
HgeneWHSC1chr4:1957915chr17:38068750ENST00000508803+15221063_1180960.33333333333341366.0DomainSET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000508803+15221187_1203960.33333333333341366.0DomainPost-SET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000514045+191011_10610630.0DomainAWS
HgeneWHSC1chr4:1957915chr17:38068750ENST00000514045+191063_11800630.0DomainSET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000514045+191187_12030630.0DomainPost-SET
HgeneWHSC1chr4:1957915chr17:38068750ENST00000514045+19222_2860630.0DomainPWWP 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000514045+19880_9420630.0DomainPWWP 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382888+5121115_1118308.3333333333333714.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382888+5121141_1142308.3333333333333714.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382891+15221115_1118960.33333333333341366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382891+15221141_1142960.33333333333341366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382892+16231115_1118960.33333333333341366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382892+16231141_1142960.33333333333341366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382895+17241115_1118960.33333333333341366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382895+17241141_1142960.33333333333341366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000398261+191115_11180648.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000398261+191141_11420648.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000420906+1111115_11180630.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000420906+1111141_11420630.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000436793+161115_11180274.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000436793+161141_11420274.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000503128+1101115_11180648.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000503128+1101141_11420648.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000508803+15221115_1118960.33333333333341366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000508803+15221141_1142960.33333333333341366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000514045+191115_11180630.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000514045+191141_11420630.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382888+5121239_1286308.3333333333333714.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382888+512667_713308.3333333333333714.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382888+512714_770308.3333333333333714.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382888+512831_875308.3333333333333714.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382891+15221239_1286960.33333333333341366.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382892+16231239_1286960.33333333333341366.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1957915chr17:38068750ENST00000382895+17241239_1286960.33333333333341366.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1957915chr17:38068750ENST00000398261+191239_12860648.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1957915chr17:38068750ENST00000398261+19667_7130648.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000398261+19714_7700648.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000398261+19831_8750648.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1957915chr17:38068750ENST00000420906+1111239_12860630.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1957915chr17:38068750ENST00000420906+111667_7130630.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000420906+111714_7700630.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000420906+111831_8750630.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1957915chr17:38068750ENST00000436793+161239_12860274.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1957915chr17:38068750ENST00000436793+16667_7130274.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000436793+16714_7700274.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000436793+16831_8750274.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1957915chr17:38068750ENST00000503128+1101239_12860648.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1957915chr17:38068750ENST00000503128+110667_7130648.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000503128+110714_7700648.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000503128+110831_8750648.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1957915chr17:38068750ENST00000508803+15221239_1286960.33333333333341366.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1957915chr17:38068750ENST00000514045+191239_12860630.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1957915chr17:38068750ENST00000514045+19667_7130630.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1957915chr17:38068750ENST00000514045+19714_7700630.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1957915chr17:38068750ENST00000514045+19831_8750630.0Zinc fingerPHD-type 3
TgeneGSDMBchr4:1957915chr17:38068750ENST000003094811101_27578.33333333333333404.0RegionTriggers pyroptosis
TgeneGSDMBchr4:1957915chr17:38068750ENST000003603170101_27578.33333333333333417.0RegionTriggers pyroptosis
TgeneGSDMBchr4:1957915chr17:38068750ENST00000394175081_27578.33333333333333395.0RegionTriggers pyroptosis
TgeneGSDMBchr4:1957915chr17:38068750ENST000003941791101_27578.33333333333333412.0RegionTriggers pyroptosis
TgeneGSDMBchr4:1957915chr17:38068750ENST000004185191111_27578.33333333333333417.0RegionTriggers pyroptosis
TgeneGSDMBchr4:1957915chr17:38068750ENST000005205421101_27578.33333333333333408.0RegionTriggers pyroptosis


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

all structure
GSDMB_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
WHSC1
GSDMB


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to WHSC1-GSDMB


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to WHSC1-GSDMB


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource