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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:WHSC1L1-ADAM18

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: WHSC1L1-ADAM18
FusionPDB ID: 99193
FusionGDB2.0 ID: 99193
HgeneTgene
Gene symbol

WHSC1L1

ADAM18

Gene ID

54904

8749

Gene namenuclear receptor binding SET domain protein 3ADAM metallopeptidase domain 18
SynonymsKMT3F|KMT3G|WHISTLE|WHSC1L1|pp14328ADAM27|tMDCIII
Cytomap

8p11.23

8p11.22

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase NSD3WHSC1-like 1 isoform 9 with methyltransferase activity to lysineWolf-Hirschhorn syndrome candidate 1-like 1nuclear SET domain-containing protein 3protein whistledisintegrin and metalloproteinase domain-containing protein 18a disintegrin and metalloproteinase domain 18transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III
Modification date2020031320200313
UniProtAcc.

Q9Y3Q7

Ensembl transtripts involved in fusion geneENST idsENST00000317025, ENST00000433384, 
ENST00000527502, ENST00000316985, 
ENST00000525081, 		ENST00000523755, 
ENST00000520772, ENST00000541111, 
ENST00000379866, ENST00000265707, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score31 X 27 X 13=108818 X 8 X 6=384
# samples 469
** MAII scorelog2(46/10881*10)=-4.56403347974706
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/384*10)=-2.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: WHSC1L1 [Title/Abstract] AND ADAM18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)WHSC1L1(38137058)-ADAM18(39587417), # samples:2
Anticipated loss of major functional domain due to fusion event.WHSC1L1-ADAM18 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WHSC1L1-ADAM18 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WHSC1L1-ADAM18 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WHSC1L1-ADAM18 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WHSC1L1-ADAM18 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
WHSC1L1-ADAM18 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
WHSC1L1-ADAM18 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
WHSC1L1-ADAM18 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWHSC1L1

GO:0016571

histone methylation

16682010


check buttonFusion gene breakpoints across WHSC1L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADAM18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-D5-6926-01AWHSC1L1chr8

38137058

-ADAM18chr8

39587417

+
ChimerDB4COADTCGA-D5-6926WHSC1L1chr8

38137057

-ADAM18chr8

39587416

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000317025WHSC1L1chr838137057-ENST00000265707ADAM18chr839587416+4444427851843481276
ENST00000433384WHSC1L1chr838137057-ENST00000265707ADAM18chr839587416+4270410449141741227
ENST00000527502WHSC1L1chr838137057-ENST00000265707ADAM18chr839587416+398538199238891265
ENST00000317025WHSC1L1chr838137058-ENST00000265707ADAM18chr839587417+4444427851843481276
ENST00000433384WHSC1L1chr838137058-ENST00000265707ADAM18chr839587417+4270410449141741227
ENST00000527502WHSC1L1chr838137058-ENST00000265707ADAM18chr839587417+398538199238891265

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317025ENST00000265707WHSC1L1chr838137057-ADAM18chr839587416+0.0009716080.99902844
ENST00000433384ENST00000265707WHSC1L1chr838137057-ADAM18chr839587416+0.0009693820.9990306
ENST00000527502ENST00000265707WHSC1L1chr838137057-ADAM18chr839587416+0.0006523980.9993476
ENST00000317025ENST00000265707WHSC1L1chr838137058-ADAM18chr839587417+0.0009716080.99902844
ENST00000433384ENST00000265707WHSC1L1chr838137058-ADAM18chr839587417+0.0009693820.9990306
ENST00000527502ENST00000265707WHSC1L1chr838137058-ADAM18chr839587417+0.0006523980.9993476

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99193_99193_1_WHSC1L1-ADAM18_WHSC1L1_chr8_38137057_ENST00000317025_ADAM18_chr8_39587416_ENST00000265707_length(amino acids)=1276AA_BP=1253
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYN
QYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV
QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQV
GDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR
PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRH
SQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ
DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPL
KKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGE
CCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHK
ASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAE
LMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQG
LKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANK
VIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEF
VNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAVIHPLYQ

--------------------------------------------------------------

>99193_99193_2_WHSC1L1-ADAM18_WHSC1L1_chr8_38137057_ENST00000433384_ADAM18_chr8_39587416_ENST00000265707_length(amino acids)=1227AA_BP=1204
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYN
QYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV
QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQV
GDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR
PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRH
SQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ
DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPL
KKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGE
CCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHK
ASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGGRLLCCESCPASFHPECLSIEMPEGCWNC
NDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKK
ALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCP
AGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYS

--------------------------------------------------------------

>99193_99193_3_WHSC1L1-ADAM18_WHSC1L1_chr8_38137057_ENST00000527502_ADAM18_chr8_39587416_ENST00000265707_length(amino acids)=1265AA_BP=1242
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYN
QYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV
QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQV
GDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR
PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRH
SQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ
DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPL
KKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGE
CCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHK
ASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAE
LMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQG
LKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANK
VIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEF
VNEYVGELIDEEECRLRIKRAHENSDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAVIHPLYQKAMTWDINIAQ

--------------------------------------------------------------

>99193_99193_4_WHSC1L1-ADAM18_WHSC1L1_chr8_38137058_ENST00000317025_ADAM18_chr8_39587417_ENST00000265707_length(amino acids)=1276AA_BP=1253
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYN
QYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV
QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQV
GDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR
PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRH
SQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ
DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPL
KKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGE
CCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHK
ASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAE
LMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQG
LKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANK
VIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEF
VNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAVIHPLYQ

--------------------------------------------------------------

>99193_99193_5_WHSC1L1-ADAM18_WHSC1L1_chr8_38137058_ENST00000433384_ADAM18_chr8_39587417_ENST00000265707_length(amino acids)=1227AA_BP=1204
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYN
QYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV
QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQV
GDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR
PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRH
SQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ
DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPL
KKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGE
CCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHK
ASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGGRLLCCESCPASFHPECLSIEMPEGCWNC
NDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKK
ALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCP
AGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYS

--------------------------------------------------------------

>99193_99193_6_WHSC1L1-ADAM18_WHSC1L1_chr8_38137058_ENST00000527502_ADAM18_chr8_39587417_ENST00000265707_length(amino acids)=1265AA_BP=1242
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYN
QYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV
QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQV
GDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR
PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRH
SQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ
DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPL
KKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGE
CCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHK
ASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAE
LMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQG
LKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANK
VIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEF
VNEYVGELIDEEECRLRIKRAHENSDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAVIHPLYQKAMTWDINIAQ

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38137058/chr8:39587417)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ADAM18

Q9Y3Q7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000317025-21241033_10691253.33333333333331438.0Coiled coilOntology_term=ECO:0000255
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000433384-20231033_10691204.33333333333331389.0Coiled coilOntology_term=ECO:0000255
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000317025-21241033_10691253.33333333333331438.0Coiled coilOntology_term=ECO:0000255
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000433384-20231033_10691204.33333333333331389.0Coiled coilOntology_term=ECO:0000255
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000317025-21241093_11431253.33333333333331438.0DomainAWS
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000317025-2124270_3331253.33333333333331438.0DomainPWWP 1
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000317025-2124960_10221253.33333333333331438.0DomainPWWP 2
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000433384-20231093_11431204.33333333333331389.0DomainAWS
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000433384-2023270_3331204.33333333333331389.0DomainPWWP 1
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000433384-2023960_10221204.33333333333331389.0DomainPWWP 2
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000317025-21241093_11431253.33333333333331438.0DomainAWS
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000317025-2124270_3331253.33333333333331438.0DomainPWWP 1
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000317025-2124960_10221253.33333333333331438.0DomainPWWP 2
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000433384-20231093_11431204.33333333333331389.0DomainAWS
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000433384-2023270_3331204.33333333333331389.0DomainPWWP 1
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000433384-2023960_10221204.33333333333331389.0DomainPWWP 2
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000317025-2124701_7481253.33333333333331438.0Zinc fingerPHD-type 1
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000317025-2124749_8051253.33333333333331438.0Zinc fingerPHD-type 2
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000317025-2124862_9551253.33333333333331438.0Zinc fingerPHD-type 3
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000433384-2023701_7481204.33333333333331389.0Zinc fingerPHD-type 1
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000433384-2023749_8051204.33333333333331389.0Zinc fingerPHD-type 2
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000433384-2023862_9551204.33333333333331389.0Zinc fingerPHD-type 3
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000317025-2124701_7481253.33333333333331438.0Zinc fingerPHD-type 1
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000317025-2124749_8051253.33333333333331438.0Zinc fingerPHD-type 2
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000317025-2124862_9551253.33333333333331438.0Zinc fingerPHD-type 3
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000433384-2023701_7481204.33333333333331389.0Zinc fingerPHD-type 1
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000433384-2023749_8051204.33333333333331389.0Zinc fingerPHD-type 2
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000433384-2023862_9551204.33333333333331389.0Zinc fingerPHD-type 3
TgeneADAM18chr8:38137057chr8:39587416ENST0000052077206480_6220183.0Compositional biasNote=Cys-rich
TgeneADAM18chr8:38137058chr8:39587417ENST0000052077206480_6220183.0Compositional biasNote=Cys-rich
TgeneADAM18chr8:38137057chr8:39587416ENST0000052077206184_3810183.0DomainPeptidase M12B
TgeneADAM18chr8:38137057chr8:39587416ENST0000052077206390_4790183.0DomainDisintegrin
TgeneADAM18chr8:38137057chr8:39587416ENST0000052077206620_6540183.0DomainNote=EGF-like
TgeneADAM18chr8:38137058chr8:39587417ENST0000052077206184_3810183.0DomainPeptidase M12B
TgeneADAM18chr8:38137058chr8:39587417ENST0000052077206390_4790183.0DomainDisintegrin
TgeneADAM18chr8:38137058chr8:39587417ENST0000052077206620_6540183.0DomainNote=EGF-like
TgeneADAM18chr8:38137057chr8:39587416ENST000003798661719709_739701.6666666666666716.0Topological domainCytoplasmic
TgeneADAM18chr8:38137057chr8:39587416ENST0000052077206177_6870183.0Topological domainExtracellular
TgeneADAM18chr8:38137057chr8:39587416ENST0000052077206709_7390183.0Topological domainCytoplasmic
TgeneADAM18chr8:38137058chr8:39587417ENST000003798661719709_739701.6666666666666716.0Topological domainCytoplasmic
TgeneADAM18chr8:38137058chr8:39587417ENST0000052077206177_6870183.0Topological domainExtracellular
TgeneADAM18chr8:38137058chr8:39587417ENST0000052077206709_7390183.0Topological domainCytoplasmic
TgeneADAM18chr8:38137057chr8:39587416ENST0000052077206688_7080183.0TransmembraneHelical
TgeneADAM18chr8:38137058chr8:39587417ENST0000052077206688_7080183.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000316985-1101033_10690646.0Coiled coilOntology_term=ECO:0000255
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000316985-1101033_10690646.0Coiled coilOntology_term=ECO:0000255
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000316985-1101093_11430646.0DomainAWS
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000316985-1101145_12620646.0DomainSET
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000316985-1101269_12850646.0DomainPost-SET
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000316985-110270_3330646.0DomainPWWP 1
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000316985-110960_10220646.0DomainPWWP 2
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000317025-21241145_12621253.33333333333331438.0DomainSET
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000317025-21241269_12851253.33333333333331438.0DomainPost-SET
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000433384-20231145_12621204.33333333333331389.0DomainSET
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000433384-20231269_12851204.33333333333331389.0DomainPost-SET
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000316985-1101093_11430646.0DomainAWS
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000316985-1101145_12620646.0DomainSET
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000316985-1101269_12850646.0DomainPost-SET
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000316985-110270_3330646.0DomainPWWP 1
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000316985-110960_10220646.0DomainPWWP 2
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000317025-21241145_12621253.33333333333331438.0DomainSET
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000317025-21241269_12851253.33333333333331438.0DomainPost-SET
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000433384-20231145_12621204.33333333333331389.0DomainSET
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000433384-20231269_12851204.33333333333331389.0DomainPost-SET
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000316985-1101321_13680646.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000316985-110701_7480646.0Zinc fingerPHD-type 1
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000316985-110749_8050646.0Zinc fingerPHD-type 2
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000316985-110862_9550646.0Zinc fingerPHD-type 3
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000317025-21241321_13681253.33333333333331438.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1L1chr8:38137057chr8:39587416ENST00000433384-20231321_13681204.33333333333331389.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000316985-1101321_13680646.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000316985-110701_7480646.0Zinc fingerPHD-type 1
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000316985-110749_8050646.0Zinc fingerPHD-type 2
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000316985-110862_9550646.0Zinc fingerPHD-type 3
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000317025-21241321_13681253.33333333333331438.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1L1chr8:38137058chr8:39587417ENST00000433384-20231321_13681204.33333333333331389.0Zinc fingerPHD-type 4%3B atypical
TgeneADAM18chr8:38137057chr8:39587416ENST000002657071820480_622725.6666666666666740.0Compositional biasNote=Cys-rich
TgeneADAM18chr8:38137057chr8:39587416ENST000003798661719480_622701.6666666666666716.0Compositional biasNote=Cys-rich
TgeneADAM18chr8:38137058chr8:39587417ENST000002657071820480_622725.6666666666666740.0Compositional biasNote=Cys-rich
TgeneADAM18chr8:38137058chr8:39587417ENST000003798661719480_622701.6666666666666716.0Compositional biasNote=Cys-rich
TgeneADAM18chr8:38137057chr8:39587416ENST000002657071820184_381725.6666666666666740.0DomainPeptidase M12B
TgeneADAM18chr8:38137057chr8:39587416ENST000002657071820390_479725.6666666666666740.0DomainDisintegrin
TgeneADAM18chr8:38137057chr8:39587416ENST000002657071820620_654725.6666666666666740.0DomainNote=EGF-like
TgeneADAM18chr8:38137057chr8:39587416ENST000003798661719184_381701.6666666666666716.0DomainPeptidase M12B
TgeneADAM18chr8:38137057chr8:39587416ENST000003798661719390_479701.6666666666666716.0DomainDisintegrin
TgeneADAM18chr8:38137057chr8:39587416ENST000003798661719620_654701.6666666666666716.0DomainNote=EGF-like
TgeneADAM18chr8:38137058chr8:39587417ENST000002657071820184_381725.6666666666666740.0DomainPeptidase M12B
TgeneADAM18chr8:38137058chr8:39587417ENST000002657071820390_479725.6666666666666740.0DomainDisintegrin
TgeneADAM18chr8:38137058chr8:39587417ENST000002657071820620_654725.6666666666666740.0DomainNote=EGF-like
TgeneADAM18chr8:38137058chr8:39587417ENST000003798661719184_381701.6666666666666716.0DomainPeptidase M12B
TgeneADAM18chr8:38137058chr8:39587417ENST000003798661719390_479701.6666666666666716.0DomainDisintegrin
TgeneADAM18chr8:38137058chr8:39587417ENST000003798661719620_654701.6666666666666716.0DomainNote=EGF-like
TgeneADAM18chr8:38137057chr8:39587416ENST000002657071820177_687725.6666666666666740.0Topological domainExtracellular
TgeneADAM18chr8:38137057chr8:39587416ENST000002657071820709_739725.6666666666666740.0Topological domainCytoplasmic
TgeneADAM18chr8:38137057chr8:39587416ENST000003798661719177_687701.6666666666666716.0Topological domainExtracellular
TgeneADAM18chr8:38137058chr8:39587417ENST000002657071820177_687725.6666666666666740.0Topological domainExtracellular
TgeneADAM18chr8:38137058chr8:39587417ENST000002657071820709_739725.6666666666666740.0Topological domainCytoplasmic
TgeneADAM18chr8:38137058chr8:39587417ENST000003798661719177_687701.6666666666666716.0Topological domainExtracellular
TgeneADAM18chr8:38137057chr8:39587416ENST000002657071820688_708725.6666666666666740.0TransmembraneHelical
TgeneADAM18chr8:38137057chr8:39587416ENST000003798661719688_708701.6666666666666716.0TransmembraneHelical
TgeneADAM18chr8:38137058chr8:39587417ENST000002657071820688_708725.6666666666666740.0TransmembraneHelical
TgeneADAM18chr8:38137058chr8:39587417ENST000003798661719688_708701.6666666666666716.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
WHSC1L1
ADAM18


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to WHSC1L1-ADAM18


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to WHSC1L1-ADAM18


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource