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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:WHSC1L1-FGFR1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: WHSC1L1-FGFR1
FusionPDB ID: 99203
FusionGDB2.0 ID: 99203
HgeneTgene
Gene symbol

WHSC1L1

FGFR1

Gene ID

54904

2260

Gene namenuclear receptor binding SET domain protein 3fibroblast growth factor receptor 1
SynonymsKMT3F|KMT3G|WHISTLE|WHSC1L1|pp14328BFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1
Cytomap

8p11.23

8p11.23

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase NSD3WHSC1-like 1 isoform 9 with methyltransferase activity to lysineWolf-Hirschhorn syndrome candidate 1-like 1nuclear SET domain-containing protein 3protein whistlefibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgr
Modification date2020031320200329
UniProtAcc.

Q9NVK5

Ensembl transtripts involved in fusion geneENST idsENST00000317025, ENST00000433384, 
ENST00000527502, ENST00000316985, 
ENST00000525081, 		ENST00000496629, 
ENST00000425967, ENST00000326324, 
ENST00000335922, ENST00000341462, 
ENST00000356207, ENST00000397091, 
ENST00000397108, ENST00000397113, 
ENST00000447712, ENST00000532791, 
ENST00000397103, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score31 X 27 X 13=1088125 X 34 X 7=5950
# samples 4622
** MAII scorelog2(46/10881*10)=-4.56403347974706
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/5950*10)=-4.75731423955801
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: WHSC1L1 [Title/Abstract] AND FGFR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)WHSC1L1(38239317)-FGFR1(38315052), # samples:6
Anticipated loss of major functional domain due to fusion event.WHSC1L1-FGFR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WHSC1L1-FGFR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WHSC1L1-FGFR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WHSC1L1-FGFR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WHSC1L1-FGFR1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
WHSC1L1-FGFR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
WHSC1L1-FGFR1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
WHSC1L1-FGFR1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
WHSC1L1-FGFR1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
WHSC1L1-FGFR1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWHSC1L1

GO:0016571

histone methylation

16682010

TgeneFGFR1

GO:0008284

positive regulation of cell proliferation

8663044

TgeneFGFR1

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

TgeneFGFR1

GO:0010863

positive regulation of phospholipase C activity

18480409

TgeneFGFR1

GO:0018108

peptidyl-tyrosine phosphorylation

8622701|18480409

TgeneFGFR1

GO:0043406

positive regulation of MAP kinase activity

8622701|18480409

TgeneFGFR1

GO:0046777

protein autophosphorylation

8622701

TgeneFGFR1

GO:2000546

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

21885851


check buttonFusion gene breakpoints across WHSC1L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FGFR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A26X-01AWHSC1L1chr8

38162105

-FGFR1chr8

38285611

-
ChimerDB4BRCATCGA-E2-A15A-01AWHSC1L1chr8

38239317

-FGFR1chr8

38315052

-
ChimerDB4BRCATCGA-E2-A15A-01AWHSC1L1chr8

38239317

-FGFR1chr8

38318773

-
ChimerDB4BRCATCGA-E2-A15A-06AWHSC1L1chr8

38239317

-FGFR1chr8

38315052

-
ChimerDB4BRCATCGA-E2-A15AWHSC1L1chr8

38239316

-FGFR1chr8

38315052

-
ChimerDB4LUADTCGA-44-4112-01AWHSC1L1chr8

38239317

-FGFR1chr8

38315052

-
ChimerDB4LUSCTCGA-77-8008WHSC1L1chr8

38162104

-FGFR1chr8

38277253

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000317025WHSC1L1chr838162104-ENST00000341462FGFR1chr838277253-700431295183265915
ENST00000433384WHSC1L1chr838162104-ENST00000341462FGFR1chr838277253-697731024913238915
ENST00000527502WHSC1L1chr838162104-ENST00000341462FGFR1chr838277253-65782703922839915

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317025ENST00000341462WHSC1L1chr838162104-FGFR1chr838277253-0.0007429110.999257
ENST00000433384ENST00000341462WHSC1L1chr838162104-FGFR1chr838277253-0.0007472240.99925274
ENST00000527502ENST00000341462WHSC1L1chr838162104-FGFR1chr838277253-0.0006238560.9993761

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99203_99203_1_WHSC1L1-FGFR1_WHSC1L1_chr8_38162104_ENST00000317025_FGFR1_chr8_38277253_ENST00000341462_length(amino acids)=915AA_BP=871
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYN
QYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV
QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQV
GDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR
PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRH
SQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ
DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPL
KKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGE
CCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHK
ASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARAGREAGSDDLAPVPGDHHLLHRGLPHLLHG

--------------------------------------------------------------

>99203_99203_2_WHSC1L1-FGFR1_WHSC1L1_chr8_38162104_ENST00000433384_FGFR1_chr8_38277253_ENST00000341462_length(amino acids)=915AA_BP=871
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYN
QYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV
QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQV
GDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR
PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRH
SQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ
DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPL
KKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGE
CCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHK
ASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARAGREAGSDDLAPVPGDHHLLHRGLPHLLHG

--------------------------------------------------------------

>99203_99203_3_WHSC1L1-FGFR1_WHSC1L1_chr8_38162104_ENST00000527502_FGFR1_chr8_38277253_ENST00000341462_length(amino acids)=915AA_BP=871
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYN
QYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV
QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQV
GDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR
PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRH
SQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ
DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPL
KKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGE
CCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHK
ASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARAGREAGSDDLAPVPGDHHLLHRGLPHLLHG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38239317/chr8:38315052)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FGFR1

Q9NVK5

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May be involved in wound healing pathway. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000317025-1424270_333870.33333333333341438.0DomainPWWP 1
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000433384-1423270_333870.33333333333341389.0DomainPWWP 1
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000317025-1424701_748870.33333333333341438.0Zinc fingerPHD-type 1
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000317025-1424749_805870.33333333333341438.0Zinc fingerPHD-type 2
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000433384-1423701_748870.33333333333341389.0Zinc fingerPHD-type 1
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000433384-1423749_805870.33333333333341389.0Zinc fingerPHD-type 2
TgeneFGFR1chr8:38162104chr8:38277253ENST00000326324617478_767269.3333333333333732.0DomainProtein kinase
TgeneFGFR1chr8:38162104chr8:38277253ENST00000335922819478_767352.3333333333333813.0DomainProtein kinase
TgeneFGFR1chr8:38162104chr8:38277253ENST00000356207617478_767271.3333333333333734.0DomainProtein kinase
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397091718478_767358.3333333333333821.0DomainProtein kinase
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397108819478_767358.3333333333333821.0DomainProtein kinase
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397113718478_767358.3333333333333821.0DomainProtein kinase
TgeneFGFR1chr8:38162104chr8:38277253ENST00000425967819478_767391.3333333333333854.0DomainProtein kinase
TgeneFGFR1chr8:38162104chr8:38277253ENST00000447712718478_767360.3333333333333823.0DomainProtein kinase
TgeneFGFR1chr8:38162104chr8:38277253ENST00000532791718478_767360.3333333333333821.0DomainProtein kinase
TgeneFGFR1chr8:38162104chr8:38277253ENST00000326324617484_490269.3333333333333732.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000326324617562_564269.3333333333333732.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000335922819484_490352.3333333333333813.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000335922819562_564352.3333333333333813.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000356207617484_490271.3333333333333734.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000356207617562_564271.3333333333333734.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397091718484_490358.3333333333333821.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397091718562_564358.3333333333333821.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397108819484_490358.3333333333333821.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397108819562_564358.3333333333333821.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397113718484_490358.3333333333333821.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397113718562_564358.3333333333333821.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000425967819484_490391.3333333333333854.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000425967819562_564391.3333333333333854.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000447712718484_490360.3333333333333823.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000447712718562_564360.3333333333333823.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000532791718484_490360.3333333333333821.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000532791718562_564360.3333333333333821.0Nucleotide bindingNote=ATP
TgeneFGFR1chr8:38162104chr8:38277253ENST00000326324617398_822269.3333333333333732.0Topological domainCytoplasmic
TgeneFGFR1chr8:38162104chr8:38277253ENST00000335922819398_822352.3333333333333813.0Topological domainCytoplasmic
TgeneFGFR1chr8:38162104chr8:38277253ENST00000356207617398_822271.3333333333333734.0Topological domainCytoplasmic
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397091718398_822358.3333333333333821.0Topological domainCytoplasmic
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397108819398_822358.3333333333333821.0Topological domainCytoplasmic
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397113718398_822358.3333333333333821.0Topological domainCytoplasmic
TgeneFGFR1chr8:38162104chr8:38277253ENST00000425967819398_822391.3333333333333854.0Topological domainCytoplasmic
TgeneFGFR1chr8:38162104chr8:38277253ENST00000447712718398_822360.3333333333333823.0Topological domainCytoplasmic
TgeneFGFR1chr8:38162104chr8:38277253ENST00000532791718398_822360.3333333333333821.0Topological domainCytoplasmic
TgeneFGFR1chr8:38162104chr8:38277253ENST00000326324617377_397269.3333333333333732.0TransmembraneHelical
TgeneFGFR1chr8:38162104chr8:38277253ENST00000335922819377_397352.3333333333333813.0TransmembraneHelical
TgeneFGFR1chr8:38162104chr8:38277253ENST00000356207617377_397271.3333333333333734.0TransmembraneHelical
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397091718377_397358.3333333333333821.0TransmembraneHelical
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397108819377_397358.3333333333333821.0TransmembraneHelical
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397113718377_397358.3333333333333821.0TransmembraneHelical
TgeneFGFR1chr8:38162104chr8:38277253ENST00000447712718377_397360.3333333333333823.0TransmembraneHelical
TgeneFGFR1chr8:38162104chr8:38277253ENST00000532791718377_397360.3333333333333821.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000316985-1101033_10690646.0Coiled coilOntology_term=ECO:0000255
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000317025-14241033_1069870.33333333333341438.0Coiled coilOntology_term=ECO:0000255
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000433384-14231033_1069870.33333333333341389.0Coiled coilOntology_term=ECO:0000255
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000316985-1101093_11430646.0DomainAWS
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000316985-1101145_12620646.0DomainSET
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000316985-1101269_12850646.0DomainPost-SET
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000316985-110270_3330646.0DomainPWWP 1
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000316985-110960_10220646.0DomainPWWP 2
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000317025-14241093_1143870.33333333333341438.0DomainAWS
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000317025-14241145_1262870.33333333333341438.0DomainSET
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000317025-14241269_1285870.33333333333341438.0DomainPost-SET
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000317025-1424960_1022870.33333333333341438.0DomainPWWP 2
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000433384-14231093_1143870.33333333333341389.0DomainAWS
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000433384-14231145_1262870.33333333333341389.0DomainSET
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000433384-14231269_1285870.33333333333341389.0DomainPost-SET
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000433384-1423960_1022870.33333333333341389.0DomainPWWP 2
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000316985-1101321_13680646.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000316985-110701_7480646.0Zinc fingerPHD-type 1
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000316985-110749_8050646.0Zinc fingerPHD-type 2
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000316985-110862_9550646.0Zinc fingerPHD-type 3
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000317025-14241321_1368870.33333333333341438.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000317025-1424862_955870.33333333333341438.0Zinc fingerPHD-type 3
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000433384-14231321_1368870.33333333333341389.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1L1chr8:38162104chr8:38277253ENST00000433384-1423862_955870.33333333333341389.0Zinc fingerPHD-type 3
TgeneFGFR1chr8:38162104chr8:38277253ENST00000326324617158_246269.3333333333333732.0DomainNote=Ig-like C2-type 2
TgeneFGFR1chr8:38162104chr8:38277253ENST00000326324617255_357269.3333333333333732.0DomainNote=Ig-like C2-type 3
TgeneFGFR1chr8:38162104chr8:38277253ENST0000032632461725_119269.3333333333333732.0DomainNote=Ig-like C2-type 1
TgeneFGFR1chr8:38162104chr8:38277253ENST00000335922819158_246352.3333333333333813.0DomainNote=Ig-like C2-type 2
TgeneFGFR1chr8:38162104chr8:38277253ENST00000335922819255_357352.3333333333333813.0DomainNote=Ig-like C2-type 3
TgeneFGFR1chr8:38162104chr8:38277253ENST0000033592281925_119352.3333333333333813.0DomainNote=Ig-like C2-type 1
TgeneFGFR1chr8:38162104chr8:38277253ENST00000356207617158_246271.3333333333333734.0DomainNote=Ig-like C2-type 2
TgeneFGFR1chr8:38162104chr8:38277253ENST00000356207617255_357271.3333333333333734.0DomainNote=Ig-like C2-type 3
TgeneFGFR1chr8:38162104chr8:38277253ENST0000035620761725_119271.3333333333333734.0DomainNote=Ig-like C2-type 1
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397091718158_246358.3333333333333821.0DomainNote=Ig-like C2-type 2
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397091718255_357358.3333333333333821.0DomainNote=Ig-like C2-type 3
TgeneFGFR1chr8:38162104chr8:38277253ENST0000039709171825_119358.3333333333333821.0DomainNote=Ig-like C2-type 1
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397108819158_246358.3333333333333821.0DomainNote=Ig-like C2-type 2
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397108819255_357358.3333333333333821.0DomainNote=Ig-like C2-type 3
TgeneFGFR1chr8:38162104chr8:38277253ENST0000039710881925_119358.3333333333333821.0DomainNote=Ig-like C2-type 1
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397113718158_246358.3333333333333821.0DomainNote=Ig-like C2-type 2
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397113718255_357358.3333333333333821.0DomainNote=Ig-like C2-type 3
TgeneFGFR1chr8:38162104chr8:38277253ENST0000039711371825_119358.3333333333333821.0DomainNote=Ig-like C2-type 1
TgeneFGFR1chr8:38162104chr8:38277253ENST00000425967819158_246391.3333333333333854.0DomainNote=Ig-like C2-type 2
TgeneFGFR1chr8:38162104chr8:38277253ENST00000425967819255_357391.3333333333333854.0DomainNote=Ig-like C2-type 3
TgeneFGFR1chr8:38162104chr8:38277253ENST0000042596781925_119391.3333333333333854.0DomainNote=Ig-like C2-type 1
TgeneFGFR1chr8:38162104chr8:38277253ENST00000447712718158_246360.3333333333333823.0DomainNote=Ig-like C2-type 2
TgeneFGFR1chr8:38162104chr8:38277253ENST00000447712718255_357360.3333333333333823.0DomainNote=Ig-like C2-type 3
TgeneFGFR1chr8:38162104chr8:38277253ENST0000044771271825_119360.3333333333333823.0DomainNote=Ig-like C2-type 1
TgeneFGFR1chr8:38162104chr8:38277253ENST00000532791718158_246360.3333333333333821.0DomainNote=Ig-like C2-type 2
TgeneFGFR1chr8:38162104chr8:38277253ENST00000532791718255_357360.3333333333333821.0DomainNote=Ig-like C2-type 3
TgeneFGFR1chr8:38162104chr8:38277253ENST0000053279171825_119360.3333333333333821.0DomainNote=Ig-like C2-type 1
TgeneFGFR1chr8:38162104chr8:38277253ENST00000326324617160_177269.3333333333333732.0RegionNote=Heparin-binding
TgeneFGFR1chr8:38162104chr8:38277253ENST00000335922819160_177352.3333333333333813.0RegionNote=Heparin-binding
TgeneFGFR1chr8:38162104chr8:38277253ENST00000356207617160_177271.3333333333333734.0RegionNote=Heparin-binding
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397091718160_177358.3333333333333821.0RegionNote=Heparin-binding
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397108819160_177358.3333333333333821.0RegionNote=Heparin-binding
TgeneFGFR1chr8:38162104chr8:38277253ENST00000397113718160_177358.3333333333333821.0RegionNote=Heparin-binding
TgeneFGFR1chr8:38162104chr8:38277253ENST00000425967819160_177391.3333333333333854.0RegionNote=Heparin-binding
TgeneFGFR1chr8:38162104chr8:38277253ENST00000447712718160_177360.3333333333333823.0RegionNote=Heparin-binding
TgeneFGFR1chr8:38162104chr8:38277253ENST00000532791718160_177360.3333333333333821.0RegionNote=Heparin-binding
TgeneFGFR1chr8:38162104chr8:38277253ENST0000032632461722_376269.3333333333333732.0Topological domainExtracellular
TgeneFGFR1chr8:38162104chr8:38277253ENST0000033592281922_376352.3333333333333813.0Topological domainExtracellular
TgeneFGFR1chr8:38162104chr8:38277253ENST0000035620761722_376271.3333333333333734.0Topological domainExtracellular
TgeneFGFR1chr8:38162104chr8:38277253ENST0000039709171822_376358.3333333333333821.0Topological domainExtracellular
TgeneFGFR1chr8:38162104chr8:38277253ENST0000039710881922_376358.3333333333333821.0Topological domainExtracellular
TgeneFGFR1chr8:38162104chr8:38277253ENST0000039711371822_376358.3333333333333821.0Topological domainExtracellular
TgeneFGFR1chr8:38162104chr8:38277253ENST0000042596781922_376391.3333333333333854.0Topological domainExtracellular
TgeneFGFR1chr8:38162104chr8:38277253ENST0000044771271822_376360.3333333333333823.0Topological domainExtracellular
TgeneFGFR1chr8:38162104chr8:38277253ENST0000053279171822_376360.3333333333333821.0Topological domainExtracellular
TgeneFGFR1chr8:38162104chr8:38277253ENST00000425967819377_397391.3333333333333854.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
FGFR1FDPS, FRS3, NCAM1, FGF1, FGFR1, FRS2, PLCG1, FGF2, SHB, GRB14, BNIP2, KPNB1, CREBBP, STAT3, JAK2, SRC, NEDD4, PPP2R1B, FGF23, PTK6, ITK, NCK1, VAV1, HSP90AA1, ERBB3, CTPS2, CDK9, RPS6KA3, CDC20, TSPAN3, CEACAM21, IL20RB, LGALS8, TGFBR2, GINM1, DLK1, LTBR, TNFRSF10B, EVI2A, MREG, HEPACAM2, GOLGA7B, LDLRAD4, CRK, CTNNB1, CDH1, FGF8, SOS1, PIK3R1, PKM, FGF3, FGF5, FGF6, FGF9, FGF10, FGF17, CD44, RPS6KA1, SLA, PIK3R2, SH3BP2, NCK2, TENC1, RTN1, RTN3, PVRL1, EPHA4, YES1, L1CAM, TNK2, AKT1, PDP1, FGFR2, FAM8A1, TMEM30B, LRRN2, LITAF, C16orf58, ZDHHC11, IFNGR1, GAD1, FCGRT, IL27RA, RAET1E, SLC1A1, C14orf37, MANSC1, TPCN2, CD79B, SCN3B, C19orf45, HTR1A, FLRT1, KAL1, RASA1, CDH2, ZMYM2, FGF4, OPCML, SHC1, S100B, AGER, KLB, CDH11, TGFBR3, PTPN1, IL17RD, FBXO7, CRKL, RPN1, STOML2, DDOST, CANX, LMAN2, TMED9, RCN2, HSPA6, CDC37, HSPA2, ACTG1, ACTA1, PARD3, PGRMC1, PHGDH, ATP5B, VDAC1, VDAC2, SLC25A6, RUVBL2, RPA1, PLCG2, RAP1A, PHB, RAB1A, RAB5A, RAB8A, RAB4A, RAB14, RAB15, ARF4, RAB2B, RAB9A, COPA, SEC22B, TMEM109, STX12, CLPTM1, HSPA1L, DNAJC13, DNAJB1, TUBB4A, TUBA4A, AFAP1, TUBA1B, MTCH1, BAX, IMMT, GNB1, RAB7A, RAB11B, GAB1, PTPN11, RXRA, RARA, Nr4a2, H3F3A, Nr4a1, TH, UBC, SHE, Il17rd, PDGFRB, MFHAS1, PDK1, HEXIM1, LARP7, GNAI1, RIN1, ITGB3, KIAA1429, ERBB2, APEX1, ORF3a, ORF3b, CORO1C, HSP90AB3P, HSP90AB1, BAG2, MRPS7, MRPS31, MRPS14, P4HB, CDK1, HPX, ATP5O, LIMA1, TMOD3, CORO1B, ACTB, PLEC, RPL22L1, PPM1B, TBL2, DIMT1, SPATS2L, FARSB, HSD17B10, NUFIP2, TRMT10C, SND1, OBSCN, AIMP2, RARS, SRP19, POLRMT, MRPS2, MRPS26, BOLA2, ARGLU1, PFKFB3, MRPS6, CFL1, MRPS33, RPL22, KCTD5, HSPD1, EGFR, HULC, LDHA, MKRN2, DDX58, MLC1, IL3RA, IL32, AQP9, KCNE3, UGT1A7, GJA8, CLEC4A, AVPR1B, DEFB135, RNF149, C7orf34, EPB41L4A, CRLF2, DEFB109P1B, TBXA2R, NRSN1, OR1M1, IFNAR1, SYT2, CDH16, FBXO2, TSHR, MFI2, BCAN, CSNK1G2, CDHR4, CTSG, C1QTNF9B, PCDHA8, IZUMO1, CD8B, SFTPC, GREM2, DHFRL1, CD83, KCNC3, ANK1, PTPRN2, TMEM59, PCDHB7, P2RX4,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
WHSC1L1
FGFR1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to WHSC1L1-FGFR1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to WHSC1L1-FGFR1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFGFR1C1563720Kallmann Syndrome 2 (disorder)18CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFGFR1C1845146Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate6GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGFR1C0011570Mental Depression5PSYGENET
TgeneFGFR1C0011581Depressive disorder5CTD_human;PSYGENET
TgeneFGFR1C0220658Pfeiffer Syndrome5GENOMICS_ENGLAND;UNIPROT
TgeneFGFR1C0432283Osteoglophonic dwarfism5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGFR1C0041696Unipolar Depression4CTD_human;PSYGENET
TgeneFGFR1C0406612Encephalocraniocutaneous lipomatosis4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGFR1C0005586Bipolar Disorder3PSYGENET
TgeneFGFR1C0795998JACKSON-WEISS SYNDROME3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFGFR1C1269683Major Depressive Disorder3PSYGENET
TgeneFGFR1C0006142Malignant neoplasm of breast2CGI;CTD_human
TgeneFGFR1C0007131Non-Small Cell Lung Carcinoma2CTD_human
TgeneFGFR1C0007137Squamous cell carcinoma2CTD_human
TgeneFGFR1C0027022Myeloproliferative disease2CTD_human
TgeneFGFR1C0162809Kallmann Syndrome2CTD_human;ORPHANET
TgeneFGFR1C0432122Interfrontal craniofaciosynostosis2GENOMICS_ENGLAND;UNIPROT
TgeneFGFR1C0678222Breast Carcinoma2CGI;CTD_human
TgeneFGFR1C1257931Mammary Neoplasms, Human2CTD_human
TgeneFGFR1C1458155Mammary Neoplasms2CTD_human
TgeneFGFR1C4704874Mammary Carcinoma, Human2CTD_human
TgeneFGFR1C0004114Astrocytoma1CTD_human
TgeneFGFR1C0008924Cleft upper lip1CTD_human
TgeneFGFR1C0008925Cleft Palate1CTD_human
TgeneFGFR1C0010278Craniosynostosis1CTD_human;GENOMICS_ENGLAND
TgeneFGFR1C0011573Endogenous depression1CTD_human
TgeneFGFR1C0017638Glioma1CTD_human
TgeneFGFR1C0018824Heart valve disease1CTD_human
TgeneFGFR1C0024121Lung Neoplasms1CTD_human
TgeneFGFR1C0025193Melancholia1CTD_human
TgeneFGFR1C0036341Schizophrenia1CTD_human
TgeneFGFR1C0085682Hypophosphatemia1GENOMICS_ENGLAND
TgeneFGFR1C0086133Depressive Syndrome1CTD_human
TgeneFGFR1C0149925Small cell carcinoma of lung1CTD_human
TgeneFGFR1C0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneFGFR1C0206726gliosarcoma1ORPHANET
TgeneFGFR1C0242379Malignant neoplasm of lung1CTD_human
TgeneFGFR1C0259783mixed gliomas1CTD_human
TgeneFGFR1C0265535Trigonocephaly1CTD_human;ORPHANET
TgeneFGFR1C0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneFGFR1C0280785Diffuse Astrocytoma1CTD_human
TgeneFGFR1C0282126Depression, Neurotic1CTD_human
TgeneFGFR1C0334579Anaplastic astrocytoma1CTD_human
TgeneFGFR1C0334580Protoplasmic astrocytoma1CTD_human
TgeneFGFR1C0334581Gemistocytic astrocytoma1CTD_human
TgeneFGFR1C0334582Fibrillary Astrocytoma1CTD_human
TgeneFGFR1C0334583Pilocytic Astrocytoma1CTD_human
TgeneFGFR1C0334588Giant Cell Glioblastoma1ORPHANET
TgeneFGFR1C0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneFGFR1C0338503Septo-Optic Dysplasia1ORPHANET
TgeneFGFR1C0342384Idiopathic hypogonadotropic hypogonadism1GENOMICS_ENGLAND
TgeneFGFR1C0376634Craniofacial Abnormalities1CTD_human
TgeneFGFR1C0431362Lobar Holoprosencephaly1ORPHANET
TgeneFGFR1C0547065Mixed oligoastrocytoma1CTD_human
TgeneFGFR1C0555198Malignant Glioma1CTD_human
TgeneFGFR1C0750935Cerebral Astrocytoma1CTD_human
TgeneFGFR1C0750936Intracranial Astrocytoma1CTD_human
TgeneFGFR1C0751617Semilobar Holoprosencephaly1ORPHANET
TgeneFGFR1C1519086Pilomyxoid astrocytoma1ORPHANET
TgeneFGFR1C1704230Grade I Astrocytoma1CTD_human
TgeneFGFR1C1837218Cleft palate, isolated1CTD_human
TgeneFGFR1C1852406Cutis Gyrata Syndrome of Beare And Stevenson1GENOMICS_ENGLAND
TgeneFGFR1C2931196Craniofacial dysostosis type 11GENOMICS_ENGLAND
TgeneFGFR1C3150773CHROMOSOME 8p11 MYELOPROLIFERATIVE SYNDROME1ORPHANET