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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:WHSC1-NUP210L

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: WHSC1-NUP210L
	FusionPDB ID: 99231
	FusionGDB2.0 ID: 99231
		Hgene	Tgene
	Gene symbol	WHSC1	NUP210L
	Gene ID	7468	91181
	Gene name	nuclear receptor binding SET domain protein 2	nucleoporin 210 like
	Synonyms	KMT3F\|KMT3G\|MMSET\|REIIBP\|TRX5\|WHS\|WHSC1	-
	Cytomap	4p16.3	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	histone-lysine N-methyltransferase NSD2IL5 promoter REII region-binding proteinWolf-Hirschhorn syndrome candidate 1multiple myeloma SET domain containing protein type IIInuclear SET domain-containing protein 2probable histone-lysine N-methyltransfera	nuclear pore membrane glycoprotein 210-likenuclear pore membrane glycoprotein 210-like (LOC91181)nucleoporin 210kDa likenucleoporin Nup210-like
	Modification date	20200329	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000382891, ENST00000382892, ENST00000382895, ENST00000398261, ENST00000420906, ENST00000436793, ENST00000503128, ENST00000508803, ENST00000514045, ENST00000382888, ENST00000482415,	ENST00000271854, ENST00000368553, ENST00000368559,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	22 X 18 X 13=5148	14 X 14 X 7=1372
	# samples	27	18
	** MAII score	log2(27/5148*10)=-4.25298074116987 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1372*10)=-2.93021166984314 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: WHSC1 [Title/Abstract] AND NUP210L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	WHSC1(1902978)-NUP210L(153984846), # samples:2
Anticipated loss of major functional domain due to fusion event.	WHSC1-NUP210L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. WHSC1-NUP210L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across WHSC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NUP210L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-N5-A4RA-01A	WHSC1	chr4	1902978	-	NUP210L	chr1	153984846	-
ChimerDB4	UCS	TCGA-N5-A4RA	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000508803	WHSC1	chr4	1902978	+	ENST00000368559	NUP210L	chr1	153984846	-	1909	745	139	1758	539
ENST00000508803	WHSC1	chr4	1902978	+	ENST00000368553	NUP210L	chr1	153984846	-	1448	745	139	1302	387
ENST00000508803	WHSC1	chr4	1902978	+	ENST00000271854	NUP210L	chr1	153984846	-	1444	745	139	1302	387
ENST00000382892	WHSC1	chr4	1902978	+	ENST00000368559	NUP210L	chr1	153984846	-	2075	911	305	1924	539
ENST00000382892	WHSC1	chr4	1902978	+	ENST00000368553	NUP210L	chr1	153984846	-	1614	911	305	1468	387
ENST00000382892	WHSC1	chr4	1902978	+	ENST00000271854	NUP210L	chr1	153984846	-	1610	911	305	1468	387
ENST00000382891	WHSC1	chr4	1902978	+	ENST00000368559	NUP210L	chr1	153984846	-	1900	736	130	1749	539
ENST00000382891	WHSC1	chr4	1902978	+	ENST00000368553	NUP210L	chr1	153984846	-	1439	736	130	1293	387
ENST00000382891	WHSC1	chr4	1902978	+	ENST00000271854	NUP210L	chr1	153984846	-	1435	736	130	1293	387
ENST00000382895	WHSC1	chr4	1902978	+	ENST00000368559	NUP210L	chr1	153984846	-	2192	1028	422	2041	539
ENST00000382895	WHSC1	chr4	1902978	+	ENST00000368553	NUP210L	chr1	153984846	-	1731	1028	422	1585	387
ENST00000382895	WHSC1	chr4	1902978	+	ENST00000271854	NUP210L	chr1	153984846	-	1727	1028	422	1585	387
ENST00000514045	WHSC1	chr4	1902978	+	ENST00000368559	NUP210L	chr1	153984846	-	1872	708	102	1721	539
ENST00000514045	WHSC1	chr4	1902978	+	ENST00000368553	NUP210L	chr1	153984846	-	1411	708	102	1265	387
ENST00000514045	WHSC1	chr4	1902978	+	ENST00000271854	NUP210L	chr1	153984846	-	1407	708	102	1265	387
ENST00000436793	WHSC1	chr4	1902978	+	ENST00000368559	NUP210L	chr1	153984846	-	2255	1091	485	2104	539
ENST00000436793	WHSC1	chr4	1902978	+	ENST00000368553	NUP210L	chr1	153984846	-	1794	1091	485	1648	387
ENST00000436793	WHSC1	chr4	1902978	+	ENST00000271854	NUP210L	chr1	153984846	-	1790	1091	485	1648	387
ENST00000420906	WHSC1	chr4	1902978	+	ENST00000368559	NUP210L	chr1	153984846	-	2192	1028	422	2041	539
ENST00000420906	WHSC1	chr4	1902978	+	ENST00000368553	NUP210L	chr1	153984846	-	1731	1028	422	1585	387
ENST00000420906	WHSC1	chr4	1902978	+	ENST00000271854	NUP210L	chr1	153984846	-	1727	1028	422	1585	387
ENST00000503128	WHSC1	chr4	1902978	+	ENST00000368559	NUP210L	chr1	153984846	-	1968	804	198	1817	539
ENST00000503128	WHSC1	chr4	1902978	+	ENST00000368553	NUP210L	chr1	153984846	-	1507	804	198	1361	387
ENST00000503128	WHSC1	chr4	1902978	+	ENST00000271854	NUP210L	chr1	153984846	-	1503	804	198	1361	387
ENST00000398261	WHSC1	chr4	1902978	+	ENST00000368559	NUP210L	chr1	153984846	-	1790	626	20	1639	539
ENST00000398261	WHSC1	chr4	1902978	+	ENST00000368553	NUP210L	chr1	153984846	-	1329	626	20	1183	387
ENST00000398261	WHSC1	chr4	1902978	+	ENST00000271854	NUP210L	chr1	153984846	-	1325	626	20	1183	387

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000508803	ENST00000368559	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.004039486	0.99596053
ENST00000508803	ENST00000368553	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.003061323	0.9969387
ENST00000508803	ENST00000271854	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.003141051	0.99685895
ENST00000382892	ENST00000368559	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.004740323	0.9952597
ENST00000382892	ENST00000368553	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.00302718	0.9969728
ENST00000382892	ENST00000271854	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.003096194	0.99690384
ENST00000382891	ENST00000368559	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.003291422	0.9967085
ENST00000382891	ENST00000368553	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.002865162	0.9971348
ENST00000382891	ENST00000271854	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.002964557	0.9970355
ENST00000382895	ENST00000368559	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.004560561	0.99543947
ENST00000382895	ENST00000368553	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.002882281	0.99711776
ENST00000382895	ENST00000271854	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.002939462	0.9970605
ENST00000514045	ENST00000368559	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.003848797	0.99615115
ENST00000514045	ENST00000368553	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.002927038	0.99707294
ENST00000514045	ENST00000271854	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.003018922	0.9969811
ENST00000436793	ENST00000368559	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.004692897	0.99530715
ENST00000436793	ENST00000368553	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.0031508	0.99684924
ENST00000436793	ENST00000271854	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.003233086	0.9967669
ENST00000420906	ENST00000368559	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.004560561	0.99543947
ENST00000420906	ENST00000368553	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.002882281	0.99711776
ENST00000420906	ENST00000271854	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.002939462	0.9970605
ENST00000503128	ENST00000368559	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.004603754	0.9953962
ENST00000503128	ENST00000368553	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.002810539	0.99718946
ENST00000503128	ENST00000271854	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.002858949	0.9971411
ENST00000398261	ENST00000368559	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.003364174	0.99663585
ENST00000398261	ENST00000368553	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.002722408	0.99727756
ENST00000398261	ENST00000271854	WHSC1	chr4	1902978	+	NUP210L	chr1	153984846	-	0.002802026	0.997198

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99231_99231_1_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000382891_NUP210L_chr1_153984846_ENST00000271854_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_2_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000382891_NUP210L_chr1_153984846_ENST00000368553_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_3_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000382891_NUP210L_chr1_153984846_ENST00000368559_length(amino acids)=539AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKGVYVCIIKVRPQSEELLQALSVADTSVYGWATLVSERSKNGMQRILIPFIPAFYINQSELVLSHKQ
DIGEIRVLGVDRVLRKLEVISSSPVLVVAGHSHSPLTPGLAIYSVRVVNFTSFQQMASPVFINISCVLTSQSEAVVVRAMKDKLGADHCE

--------------------------------------------------------------

>99231_99231_4_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000382892_NUP210L_chr1_153984846_ENST00000271854_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_5_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000382892_NUP210L_chr1_153984846_ENST00000368553_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_6_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000382892_NUP210L_chr1_153984846_ENST00000368559_length(amino acids)=539AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKGVYVCIIKVRPQSEELLQALSVADTSVYGWATLVSERSKNGMQRILIPFIPAFYINQSELVLSHKQ
DIGEIRVLGVDRVLRKLEVISSSPVLVVAGHSHSPLTPGLAIYSVRVVNFTSFQQMASPVFINISCVLTSQSEAVVVRAMKDKLGADHCE

--------------------------------------------------------------

>99231_99231_7_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000382895_NUP210L_chr1_153984846_ENST00000271854_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_8_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000382895_NUP210L_chr1_153984846_ENST00000368553_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_9_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000382895_NUP210L_chr1_153984846_ENST00000368559_length(amino acids)=539AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKGVYVCIIKVRPQSEELLQALSVADTSVYGWATLVSERSKNGMQRILIPFIPAFYINQSELVLSHKQ
DIGEIRVLGVDRVLRKLEVISSSPVLVVAGHSHSPLTPGLAIYSVRVVNFTSFQQMASPVFINISCVLTSQSEAVVVRAMKDKLGADHCE

--------------------------------------------------------------

>99231_99231_10_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000398261_NUP210L_chr1_153984846_ENST00000271854_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_11_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000398261_NUP210L_chr1_153984846_ENST00000368553_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_12_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000398261_NUP210L_chr1_153984846_ENST00000368559_length(amino acids)=539AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKGVYVCIIKVRPQSEELLQALSVADTSVYGWATLVSERSKNGMQRILIPFIPAFYINQSELVLSHKQ
DIGEIRVLGVDRVLRKLEVISSSPVLVVAGHSHSPLTPGLAIYSVRVVNFTSFQQMASPVFINISCVLTSQSEAVVVRAMKDKLGADHCE

--------------------------------------------------------------

>99231_99231_13_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000420906_NUP210L_chr1_153984846_ENST00000271854_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_14_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000420906_NUP210L_chr1_153984846_ENST00000368553_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_15_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000420906_NUP210L_chr1_153984846_ENST00000368559_length(amino acids)=539AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKGVYVCIIKVRPQSEELLQALSVADTSVYGWATLVSERSKNGMQRILIPFIPAFYINQSELVLSHKQ
DIGEIRVLGVDRVLRKLEVISSSPVLVVAGHSHSPLTPGLAIYSVRVVNFTSFQQMASPVFINISCVLTSQSEAVVVRAMKDKLGADHCE

--------------------------------------------------------------

>99231_99231_16_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000436793_NUP210L_chr1_153984846_ENST00000271854_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_17_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000436793_NUP210L_chr1_153984846_ENST00000368553_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_18_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000436793_NUP210L_chr1_153984846_ENST00000368559_length(amino acids)=539AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKGVYVCIIKVRPQSEELLQALSVADTSVYGWATLVSERSKNGMQRILIPFIPAFYINQSELVLSHKQ
DIGEIRVLGVDRVLRKLEVISSSPVLVVAGHSHSPLTPGLAIYSVRVVNFTSFQQMASPVFINISCVLTSQSEAVVVRAMKDKLGADHCE

--------------------------------------------------------------

>99231_99231_19_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000503128_NUP210L_chr1_153984846_ENST00000271854_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_20_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000503128_NUP210L_chr1_153984846_ENST00000368553_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_21_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000503128_NUP210L_chr1_153984846_ENST00000368559_length(amino acids)=539AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKGVYVCIIKVRPQSEELLQALSVADTSVYGWATLVSERSKNGMQRILIPFIPAFYINQSELVLSHKQ
DIGEIRVLGVDRVLRKLEVISSSPVLVVAGHSHSPLTPGLAIYSVRVVNFTSFQQMASPVFINISCVLTSQSEAVVVRAMKDKLGADHCE

--------------------------------------------------------------

>99231_99231_22_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000508803_NUP210L_chr1_153984846_ENST00000271854_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_23_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000508803_NUP210L_chr1_153984846_ENST00000368553_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_24_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000508803_NUP210L_chr1_153984846_ENST00000368559_length(amino acids)=539AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKGVYVCIIKVRPQSEELLQALSVADTSVYGWATLVSERSKNGMQRILIPFIPAFYINQSELVLSHKQ
DIGEIRVLGVDRVLRKLEVISSSPVLVVAGHSHSPLTPGLAIYSVRVVNFTSFQQMASPVFINISCVLTSQSEAVVVRAMKDKLGADHCE

--------------------------------------------------------------

>99231_99231_25_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000514045_NUP210L_chr1_153984846_ENST00000271854_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_26_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000514045_NUP210L_chr1_153984846_ENST00000368553_length(amino acids)=387AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKDHCEDSAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNST

--------------------------------------------------------------

>99231_99231_27_WHSC1-NUP210L_WHSC1_chr4_1902978_ENST00000514045_NUP210L_chr1_153984846_ENST00000368559_length(amino acids)=539AA_BP=202
MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF
NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS
LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ
FSNTLLDIPASKVFQVHSDFSMEKGVYVCIIKVRPQSEELLQALSVADTSVYGWATLVSERSKNGMQRILIPFIPAFYINQSELVLSHKQ
DIGEIRVLGVDRVLRKLEVISSSPVLVVAGHSHSPLTPGLAIYSVRVVNFTSFQQMASPVFINISCVLTSQSEAVVVRAMKDKLGADHCE

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:1902978/chr1:153984846)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NUP210L

chr4:1902978

chr1:153984846

ENST00000368559

1813_1833

1551.0

1889.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382888

453_521

714.0

DNA binding

HMG box

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382891

453_521

199.0

1366.0

DNA binding

HMG box

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382892

453_521

199.0

1366.0

DNA binding

HMG box

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382895

453_521

199.0

1366.0

DNA binding

HMG box

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000398261

453_521

199.0

648.0

DNA binding

HMG box

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000420906

453_521

199.0

630.0

DNA binding

HMG box

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000436793

453_521

199.0

274.0

DNA binding

HMG box

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000503128

453_521

199.0

648.0

DNA binding

HMG box

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000508803

453_521

199.0

1366.0

DNA binding

HMG box

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000514045

453_521

199.0

630.0

DNA binding

HMG box

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382888

1011_1061

714.0

Domain

AWS

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382888

1063_1180

714.0

Domain

SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382888

1187_1203

714.0

Domain

Post-SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382888

222_286

714.0

Domain

PWWP 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382888

880_942

714.0

Domain

PWWP 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382891

1011_1061

199.0

1366.0

Domain

AWS

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382891

1063_1180

199.0

1366.0

Domain

SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382891

1187_1203

199.0

1366.0

Domain

Post-SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382891

222_286

199.0

1366.0

Domain

PWWP 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382891

880_942

199.0

1366.0

Domain

PWWP 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382892

1011_1061

199.0

1366.0

Domain

AWS

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382892

1063_1180

199.0

1366.0

Domain

SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382892

1187_1203

199.0

1366.0

Domain

Post-SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382892

222_286

199.0

1366.0

Domain

PWWP 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382892

880_942

199.0

1366.0

Domain

PWWP 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382895

1011_1061

199.0

1366.0

Domain

AWS

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382895

1063_1180

199.0

1366.0

Domain

SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382895

1187_1203

199.0

1366.0

Domain

Post-SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382895

222_286

199.0

1366.0

Domain

PWWP 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382895

880_942

199.0

1366.0

Domain

PWWP 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000398261

1011_1061

199.0

648.0

Domain

AWS

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000398261

1063_1180

199.0

648.0

Domain

SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000398261

1187_1203

199.0

648.0

Domain

Post-SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000398261

222_286

199.0

648.0

Domain

PWWP 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000398261

880_942

199.0

648.0

Domain

PWWP 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000420906

1011_1061

199.0

630.0

Domain

AWS

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000420906

1063_1180

199.0

630.0

Domain

SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000420906

1187_1203

199.0

630.0

Domain

Post-SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000420906

222_286

199.0

630.0

Domain

PWWP 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000420906

880_942

199.0

630.0

Domain

PWWP 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000436793

1011_1061

199.0

274.0

Domain

AWS

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000436793

1063_1180

199.0

274.0

Domain

SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000436793

1187_1203

199.0

274.0

Domain

Post-SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000436793

222_286

199.0

274.0

Domain

PWWP 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000436793

880_942

199.0

274.0

Domain

PWWP 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000503128

1011_1061

199.0

648.0

Domain

AWS

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000503128

1063_1180

199.0

648.0

Domain

SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000503128

1187_1203

199.0

648.0

Domain

Post-SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000503128

222_286

199.0

648.0

Domain

PWWP 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000503128

880_942

199.0

648.0

Domain

PWWP 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000508803

1011_1061

199.0

1366.0

Domain

AWS

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000508803

1063_1180

199.0

1366.0

Domain

SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000508803

1187_1203

199.0

1366.0

Domain

Post-SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000508803

222_286

199.0

1366.0

Domain

PWWP 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000508803

880_942

199.0

1366.0

Domain

PWWP 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000514045

1011_1061

199.0

630.0

Domain

AWS

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000514045

1063_1180

199.0

630.0

Domain

SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000514045

1187_1203

199.0

630.0

Domain

Post-SET

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000514045

222_286

199.0

630.0

Domain

PWWP 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000514045

880_942

199.0

630.0

Domain

PWWP 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382888

1115_1118

714.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382888

1141_1142

714.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382891

1115_1118

199.0

1366.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382891

1141_1142

199.0

1366.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382892

1115_1118

199.0

1366.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382892

1141_1142

199.0

1366.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382895

1115_1118

199.0

1366.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382895

1141_1142

199.0

1366.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000398261

1115_1118

199.0

648.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000398261

1141_1142

199.0

648.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000420906

1115_1118

199.0

630.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000420906

1141_1142

199.0

630.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000436793

1115_1118

199.0

274.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000436793

1141_1142

199.0

274.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000503128

1115_1118

199.0

648.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000503128

1141_1142

199.0

648.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000508803

1115_1118

199.0

1366.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000508803

1141_1142

199.0

1366.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000514045

1115_1118

199.0

630.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000514045

1141_1142

199.0

630.0

Region

S-adenosyl-L-methionine binding

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382888

1239_1286

714.0

Zinc finger

PHD-type 4%3B atypical

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382888

667_713

714.0

Zinc finger

PHD-type 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382888

714_770

714.0

Zinc finger

PHD-type 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382888

831_875

714.0

Zinc finger

PHD-type 3

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382891

1239_1286

199.0

1366.0

Zinc finger

PHD-type 4%3B atypical

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382891

667_713

199.0

1366.0

Zinc finger

PHD-type 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382891

714_770

199.0

1366.0

Zinc finger

PHD-type 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382891

831_875

199.0

1366.0

Zinc finger

PHD-type 3

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382892

1239_1286

199.0

1366.0

Zinc finger

PHD-type 4%3B atypical

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382892

667_713

199.0

1366.0

Zinc finger

PHD-type 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382892

714_770

199.0

1366.0

Zinc finger

PHD-type 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382892

831_875

199.0

1366.0

Zinc finger

PHD-type 3

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382895

1239_1286

199.0

1366.0

Zinc finger

PHD-type 4%3B atypical

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382895

667_713

199.0

1366.0

Zinc finger

PHD-type 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382895

714_770

199.0

1366.0

Zinc finger

PHD-type 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000382895

831_875

199.0

1366.0

Zinc finger

PHD-type 3

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000398261

1239_1286

199.0

648.0

Zinc finger

PHD-type 4%3B atypical

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000398261

667_713

199.0

648.0

Zinc finger

PHD-type 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000398261

714_770

199.0

648.0

Zinc finger

PHD-type 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000398261

831_875

199.0

648.0

Zinc finger

PHD-type 3

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000420906

1239_1286

199.0

630.0

Zinc finger

PHD-type 4%3B atypical

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000420906

667_713

199.0

630.0

Zinc finger

PHD-type 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000420906

714_770

199.0

630.0

Zinc finger

PHD-type 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000420906

831_875

199.0

630.0

Zinc finger

PHD-type 3

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000436793

1239_1286

199.0

274.0

Zinc finger

PHD-type 4%3B atypical

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000436793

667_713

199.0

274.0

Zinc finger

PHD-type 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000436793

714_770

199.0

274.0

Zinc finger

PHD-type 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000436793

831_875

199.0

274.0

Zinc finger

PHD-type 3

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000503128

1239_1286

199.0

648.0

Zinc finger

PHD-type 4%3B atypical

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000503128

667_713

199.0

648.0

Zinc finger

PHD-type 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000503128

714_770

199.0

648.0

Zinc finger

PHD-type 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000503128

831_875

199.0

648.0

Zinc finger

PHD-type 3

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000508803

1239_1286

199.0

1366.0

Zinc finger

PHD-type 4%3B atypical

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000508803

667_713

199.0

1366.0

Zinc finger

PHD-type 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000508803

714_770

199.0

1366.0

Zinc finger

PHD-type 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000508803

831_875

199.0

1366.0

Zinc finger

PHD-type 3

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000514045

1239_1286

199.0

630.0

Zinc finger

PHD-type 4%3B atypical

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000514045

667_713

199.0

630.0

Zinc finger

PHD-type 1

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000514045

714_770

199.0

630.0

Zinc finger

PHD-type 2

Hgene

WHSC1

chr4:1902978

chr1:153984846

ENST00000514045

831_875

199.0

630.0

Zinc finger

PHD-type 3

Tgene

NUP210L

chr4:1902978

chr1:153984846

ENST00000368559

1082_1154

1551.0

1889.0

Domain

BIG2

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1153_WHSC1_1902978_NUP210L_153984846_1153_WHSC1_1902978_NUP210L_153984846_ranked_0.pdb	WHSC1	1902978	1902978	ENST00000271854	NUP210L	chr1	153984846	-	MGWMEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVF NGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDS LLEQGLVEAALVSKISSPSDKKVVVNASSRLMLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQ FSNTLLDIPASKVFQVHSDFSMEKGVYVCIIKVRPQSEELLQALSVADTSVYGWATLVSERSKNGMQRILIPFIPAFYINQSELVLSHKQ DIGEIRVLGVDRVLRKLEVISSSPVLVVAGHSHSPLTPGLAIYSVRVVNFTSFQQMASPVFINISCVLTSQSEAVVVRAMKDKLGADHCE	539

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

NUP210L_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
WHSC1
NUP210L

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to WHSC1-NUP210L

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to WHSC1-NUP210L

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source