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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:WLS-TBX3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: WLS-TBX3
FusionPDB ID: 99316
FusionGDB2.0 ID: 99316
HgeneTgene
Gene symbol

WLS

TBX3

Gene ID

79971

6926

Gene nameWnt ligand secretion mediatorT-box transcription factor 3
SynonymsC1orf139|EVI|GPR177|MRP|mig-14TBX3-ISO|UMS|XHL
Cytomap

1p31.3

12q24.21

Type of geneprotein-codingprotein-coding
Descriptionprotein wntless homologG protein-coupled receptor 177integral membrane protein GPR177protein evenness interrupted homologputative NF-kappa-B-activating protein 373putative NFkB activating protein 373wntless Wnt ligand secretion mediatorT-box transcription factor TBX3T-box 3T-box protein 3bladder cancer related protein XHL
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000262348, ENST00000354777, 
ENST00000370976, ENST00000540432, 
ENST00000370971, ENST00000491811, 
ENST00000349155, ENST00000257566, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 5 X 3=753 X 1 X 2=6
# samples 53
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/6*10)=2.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: WLS [Title/Abstract] AND TBX3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)WLS(68603463)-TBX3(115110107), # samples:3
Anticipated loss of major functional domain due to fusion event.WLS-TBX3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WLS-TBX3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WLS-TBX3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WLS-TBX3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WLS-TBX3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
WLS-TBX3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
WLS-TBX3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTBX3

GO:0000122

negative regulation of transcription by RNA polymerase II

11689487

TgeneTBX3

GO:0007569

cell aging

11689487|11748239

TgeneTBX3

GO:0008284

positive regulation of cell proliferation

11689487|11748239|12032820

TgeneTBX3

GO:0009887

animal organ morphogenesis

9207801

TgeneTBX3

GO:0035136

forelimb morphogenesis

9207801

TgeneTBX3

GO:0043066

negative regulation of apoptotic process

12032820

TgeneTBX3

GO:0045662

negative regulation of myoblast differentiation

12032820

TgeneTBX3

GO:0045787

positive regulation of cell cycle

12032820

TgeneTBX3

GO:0045892

negative regulation of transcription, DNA-templated

10468588|11689487

TgeneTBX3

GO:0090398

cellular senescence

22002537


check buttonFusion gene breakpoints across WLS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TBX3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5525-01AWLSchr1

68603463

-TBX3chr12

115110107

-
ChimerDB4PRADTCGA-EJ-5525WLSchr1

68603463

-TBX3chr12

115110107

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540432WLSchr168603463-ENST00000257566TBX3chr12115110107-384818002842101605
ENST00000354777WLSchr168603463-ENST00000257566TBX3chr12115110107-380417562462057603
ENST00000262348WLSchr168603463-ENST00000257566TBX3chr12115110107-381817702542071605
ENST00000370976WLSchr168603463-ENST00000257566TBX3chr12115110107-353614882451789514

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540432ENST00000257566WLSchr168603463-TBX3chr12115110107-0.0015210090.99847895
ENST00000354777ENST00000257566WLSchr168603463-TBX3chr12115110107-0.0010079190.998992
ENST00000262348ENST00000257566WLSchr168603463-TBX3chr12115110107-0.0015000960.9984999
ENST00000370976ENST00000257566WLSchr168603463-TBX3chr12115110107-0.0013290150.99867105

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99316_99316_1_WLS-TBX3_WLS_chr1_68603463_ENST00000262348_TBX3_chr12_115110107_ENST00000257566_length(amino acids)=605AA_BP=505
MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDI
VFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECD
VLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVI
FALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQ
LTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFF
IVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGPGHVPFRKPVPLPLHVHGRSGGRLLCGSLQLGAP

--------------------------------------------------------------

>99316_99316_2_WLS-TBX3_WLS_chr1_68603463_ENST00000354777_TBX3_chr12_115110107_ENST00000257566_length(amino acids)=603AA_BP=503
MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVF
SVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVL
PFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFA
LGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLT
NPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIV
SQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGPGHVPFRKPVPLPLHVHGRSGGRLLCGSLQLGAPPP

--------------------------------------------------------------

>99316_99316_3_WLS-TBX3_WLS_chr1_68603463_ENST00000370976_TBX3_chr12_115110107_ENST00000257566_length(amino acids)=514AA_BP=414
MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIGENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDV
LPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIF
ALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQL
TNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFI
VSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGPGHVPFRKPVPLPLHVHGRSGGRLLCGSLQLGAPP

--------------------------------------------------------------

>99316_99316_4_WLS-TBX3_WLS_chr1_68603463_ENST00000540432_TBX3_chr12_115110107_ENST00000257566_length(amino acids)=605AA_BP=505
MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDI
VFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECD
VLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVI
FALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQ
LTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFF
IVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGPGHVPFRKPVPLPLHVHGRSGGRLLCGSLQLGAP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:68603463/chr12:115110107)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-11121_15505.3333333333333542.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112254_268505.3333333333333542.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112290_303505.3333333333333542.0Topological domainLumenal
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112325_331505.3333333333333542.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112353_380505.3333333333333542.0Topological domainLumenal
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-111237_232505.3333333333333542.0Topological domainLumenal
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112402_431505.3333333333333542.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112453_471505.3333333333333542.0Topological domainLumenal
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-11121_15503.3333333333333544.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112254_268503.3333333333333544.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112290_303503.3333333333333544.0Topological domainLumenal
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112325_331503.3333333333333544.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112353_380503.3333333333333544.0Topological domainLumenal
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-111237_232503.3333333333333544.0Topological domainLumenal
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112402_431503.3333333333333544.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112453_471503.3333333333333544.0Topological domainLumenal
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-10111_15414.3333333333333451.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011254_268414.3333333333333451.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011290_303414.3333333333333451.0Topological domainLumenal
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011325_331414.3333333333333451.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011353_380414.3333333333333451.0Topological domainLumenal
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-101137_232414.3333333333333451.0Topological domainLumenal
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-111216_36505.3333333333333542.0TransmembraneHelical%3B Name%3D1
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112233_253505.3333333333333542.0TransmembraneHelical%3B Name%3D2
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112269_289505.3333333333333542.0TransmembraneHelical%3B Name%3D3
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112304_324505.3333333333333542.0TransmembraneHelical%3B Name%3D4
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112332_352505.3333333333333542.0TransmembraneHelical%3B Name%3D5
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112381_401505.3333333333333542.0TransmembraneHelical%3B Name%3D6
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112432_452505.3333333333333542.0TransmembraneHelical%3B Name%3D7
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112472_492505.3333333333333542.0TransmembraneHelical%3B Name%3D8
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-111216_36503.3333333333333544.0TransmembraneHelical%3B Name%3D1
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112233_253503.3333333333333544.0TransmembraneHelical%3B Name%3D2
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112269_289503.3333333333333544.0TransmembraneHelical%3B Name%3D3
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112304_324503.3333333333333544.0TransmembraneHelical%3B Name%3D4
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112332_352503.3333333333333544.0TransmembraneHelical%3B Name%3D5
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112381_401503.3333333333333544.0TransmembraneHelical%3B Name%3D6
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112432_452503.3333333333333544.0TransmembraneHelical%3B Name%3D7
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112472_492503.3333333333333544.0TransmembraneHelical%3B Name%3D8
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-101116_36414.3333333333333451.0TransmembraneHelical%3B Name%3D1
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011233_253414.3333333333333451.0TransmembraneHelical%3B Name%3D2
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011269_289414.3333333333333451.0TransmembraneHelical%3B Name%3D3
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011304_324414.3333333333333451.0TransmembraneHelical%3B Name%3D4
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011332_352414.3333333333333451.0TransmembraneHelical%3B Name%3D5
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011381_401414.3333333333333451.0TransmembraneHelical%3B Name%3D6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWLSchr1:68603463chr12:115110107ENST00000262348-1112493_541505.3333333333333542.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000354777-1112493_541503.3333333333333544.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011402_431414.3333333333333451.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011453_471414.3333333333333451.0Topological domainLumenal
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011493_541414.3333333333333451.0Topological domainCytoplasmic
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011432_452414.3333333333333451.0TransmembraneHelical%3B Name%3D7
HgeneWLSchr1:68603463chr12:115110107ENST00000370976-1011472_492414.3333333333333451.0TransmembraneHelical%3B Name%3D8
TgeneTBX3chr1:68603463chr12:115110107ENST0000025756668107_220590.0744.0DNA bindingT-box%3B first part
TgeneTBX3chr1:68603463chr12:115110107ENST0000025756668241_305590.0744.0DNA bindingT-box%3B second part
TgeneTBX3chr1:68603463chr12:115110107ENST0000034915557107_220570.0724.0DNA bindingT-box%3B first part
TgeneTBX3chr1:68603463chr12:115110107ENST0000034915557241_305570.0724.0DNA bindingT-box%3B second part
TgeneTBX3chr1:68603463chr12:115110107ENST0000025756668544_695590.0744.0RegionNote=Transcription repression
TgeneTBX3chr1:68603463chr12:115110107ENST0000034915557544_695570.0724.0RegionNote=Transcription repression


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1282_WLS_68603463_TBX3_115110107_1282_WLS_68603463_TBX3_115110107_ranked_0.pdbWLS6860346368603463ENST00000257566TBX3chr12115110107-
MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDI
VFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECD
VLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVI
FALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQ
LTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFF
IVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGPGHVPFRKPVPLPLHVHGRSGGRLLCGSLQLGAP
605


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
WLS_pLDDT.png
all structure
all structure
TBX3_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
WLS
TBX3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to WLS-TBX3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to WLS-TBX3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource