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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:WWOX-VAT1L

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: WWOX-VAT1L
FusionPDB ID: 99500
FusionGDB2.0 ID: 99500
HgeneTgene
Gene symbol

WWOX

VAT1L

Gene ID

51741

57687

Gene nameWW domain containing oxidoreductasevesicle amine transport 1 like
SynonymsD16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1-
Cytomap

16q23.1-q23.2

16q23.1

Type of geneprotein-codingprotein-coding
DescriptionWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1synaptic vesicle membrane protein VAT-1 homolog-likevesicle amine transport protein 1 homolog (T. californica)-likevesicle amine transport protein 1 homolog-like (T. californica)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000565791, ENST00000355860, 
ENST00000402655, ENST00000406884, 
ENST00000408984, ENST00000539474, 
ENST00000566780, ENST00000569818, 
ENST00000302536, ENST00000563850, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 26 X 8=54087 X 7 X 5=245
# samples 319
** MAII scorelog2(31/5408*10)=-4.12475503100795
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/245*10)=-1.4447848426729
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: WWOX [Title/Abstract] AND VAT1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)WWOX(78133782)-VAT1L(77850818), # samples:2
Anticipated loss of major functional domain due to fusion event.WWOX-VAT1L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WWOX-VAT1L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WWOX-VAT1L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WWOX-VAT1L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WWOX-VAT1L seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
WWOX-VAT1L seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

HgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check buttonFusion gene breakpoints across WWOX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VAT1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-A6-4105-01AWWOXchr16

78198186

-VAT1Lchr16

78005747

+
ChimerDB4LUADTCGA-44-7670-01AWWOXchr16

78466649

+VAT1Lchr16

78005747

+
ChimerDB4STADTCGA-CD-8535-01AWWOXchr16

78133782

-VAT1Lchr16

77850818

+
ChimerDB4STADTCGA-CD-8535-01AWWOXchr16

78133782

+VAT1Lchr16

77850818

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000566780WWOXchr1678466649+ENST00000302536VAT1Lchr1678005747+401714223661604412
ENST00000408984WWOXchr1678466649+ENST00000302536VAT1Lchr1678005747+37361141851323412
ENST00000566780WWOXchr1678133782+ENST00000302536VAT1Lchr1677850818+39124733661499377
ENST00000406884WWOXchr1678133782+ENST00000302536VAT1Lchr1677850818+36712321251258377
ENST00000539474WWOXchr1678133782+ENST00000302536VAT1Lchr1677850818+36712321251258377
ENST00000402655WWOXchr1678133782+ENST00000302536VAT1Lchr1677850818+36712321251258377
ENST00000408984WWOXchr1678133782+ENST00000302536VAT1Lchr1677850818+3631192851218377
ENST00000355860WWOXchr1678133782+ENST00000302536VAT1Lchr1677850818+36462071001233377
ENST00000566780WWOXchr1678198186-ENST00000302536VAT1Lchr1678005747+34778823661064232
ENST00000406884WWOXchr1678198186-ENST00000302536VAT1Lchr1678005747+3236641125823232
ENST00000408984WWOXchr1678198186-ENST00000302536VAT1Lchr1678005747+319660185783232
ENST00000355860WWOXchr1678198186-ENST00000302536VAT1Lchr1678005747+3211616100798232

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000566780ENST00000302536WWOXchr1678466649+VAT1Lchr1678005747+0.0015821930.99841785
ENST00000408984ENST00000302536WWOXchr1678466649+VAT1Lchr1678005747+0.0012197620.9987802
ENST00000566780ENST00000302536WWOXchr1678133782+VAT1Lchr1677850818+0.0004011370.9995989
ENST00000406884ENST00000302536WWOXchr1678133782+VAT1Lchr1677850818+0.0003352860.99966466
ENST00000539474ENST00000302536WWOXchr1678133782+VAT1Lchr1677850818+0.0003352860.99966466
ENST00000402655ENST00000302536WWOXchr1678133782+VAT1Lchr1677850818+0.0003352860.99966466
ENST00000408984ENST00000302536WWOXchr1678133782+VAT1Lchr1677850818+0.0003215820.9996785
ENST00000355860ENST00000302536WWOXchr1678133782+VAT1Lchr1677850818+0.0003208770.9996791
ENST00000566780ENST00000302536WWOXchr1678198186-VAT1Lchr1678005747+0.0011877180.9988123
ENST00000406884ENST00000302536WWOXchr1678198186-VAT1Lchr1678005747+0.0009803720.9990196
ENST00000408984ENST00000302536WWOXchr1678198186-VAT1Lchr1678005747+0.0009279360.9990721
ENST00000355860ENST00000302536WWOXchr1678198186-VAT1Lchr1678005747+0.0009340410.99906594

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99500_99500_1_WWOX-VAT1L_WWOX_chr16_78133782_ENST00000355860_VAT1L_chr16_77850818_ENST00000302536_length(amino acids)=377AA_BP=36
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANGLNFIDLMVRQGNIDNPPKTPLVPGFECSGIVEALGDSVKGYEIGDRVMAFVNY
NAWAEVVCTPVEFVYKIPDDMSFSEAAAFPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKHEAIK
DSVTHLFDRNADYVQEVKRISAEGVDIVLDCLCGDNTGKGLSLLKPLGTYILYGSSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKV
IAGFSLLNLLFKQGRAGLIRGVVEKLIGLYNQKKIKPVVDSLWALEEVKEAMQRIHDRGNIGKLILDVEKTPTPLMANDSTETSEAGEEE

--------------------------------------------------------------

>99500_99500_2_WWOX-VAT1L_WWOX_chr16_78133782_ENST00000402655_VAT1L_chr16_77850818_ENST00000302536_length(amino acids)=377AA_BP=36
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANGLNFIDLMVRQGNIDNPPKTPLVPGFECSGIVEALGDSVKGYEIGDRVMAFVNY
NAWAEVVCTPVEFVYKIPDDMSFSEAAAFPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKHEAIK
DSVTHLFDRNADYVQEVKRISAEGVDIVLDCLCGDNTGKGLSLLKPLGTYILYGSSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKV
IAGFSLLNLLFKQGRAGLIRGVVEKLIGLYNQKKIKPVVDSLWALEEVKEAMQRIHDRGNIGKLILDVEKTPTPLMANDSTETSEAGEEE

--------------------------------------------------------------

>99500_99500_3_WWOX-VAT1L_WWOX_chr16_78133782_ENST00000406884_VAT1L_chr16_77850818_ENST00000302536_length(amino acids)=377AA_BP=36
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANGLNFIDLMVRQGNIDNPPKTPLVPGFECSGIVEALGDSVKGYEIGDRVMAFVNY
NAWAEVVCTPVEFVYKIPDDMSFSEAAAFPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKHEAIK
DSVTHLFDRNADYVQEVKRISAEGVDIVLDCLCGDNTGKGLSLLKPLGTYILYGSSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKV
IAGFSLLNLLFKQGRAGLIRGVVEKLIGLYNQKKIKPVVDSLWALEEVKEAMQRIHDRGNIGKLILDVEKTPTPLMANDSTETSEAGEEE

--------------------------------------------------------------

>99500_99500_4_WWOX-VAT1L_WWOX_chr16_78133782_ENST00000408984_VAT1L_chr16_77850818_ENST00000302536_length(amino acids)=377AA_BP=36
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANGLNFIDLMVRQGNIDNPPKTPLVPGFECSGIVEALGDSVKGYEIGDRVMAFVNY
NAWAEVVCTPVEFVYKIPDDMSFSEAAAFPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKHEAIK
DSVTHLFDRNADYVQEVKRISAEGVDIVLDCLCGDNTGKGLSLLKPLGTYILYGSSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKV
IAGFSLLNLLFKQGRAGLIRGVVEKLIGLYNQKKIKPVVDSLWALEEVKEAMQRIHDRGNIGKLILDVEKTPTPLMANDSTETSEAGEEE

--------------------------------------------------------------

>99500_99500_5_WWOX-VAT1L_WWOX_chr16_78133782_ENST00000539474_VAT1L_chr16_77850818_ENST00000302536_length(amino acids)=377AA_BP=36
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANGLNFIDLMVRQGNIDNPPKTPLVPGFECSGIVEALGDSVKGYEIGDRVMAFVNY
NAWAEVVCTPVEFVYKIPDDMSFSEAAAFPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKHEAIK
DSVTHLFDRNADYVQEVKRISAEGVDIVLDCLCGDNTGKGLSLLKPLGTYILYGSSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKV
IAGFSLLNLLFKQGRAGLIRGVVEKLIGLYNQKKIKPVVDSLWALEEVKEAMQRIHDRGNIGKLILDVEKTPTPLMANDSTETSEAGEEE

--------------------------------------------------------------

>99500_99500_6_WWOX-VAT1L_WWOX_chr16_78133782_ENST00000566780_VAT1L_chr16_77850818_ENST00000302536_length(amino acids)=377AA_BP=36
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANGLNFIDLMVRQGNIDNPPKTPLVPGFECSGIVEALGDSVKGYEIGDRVMAFVNY
NAWAEVVCTPVEFVYKIPDDMSFSEAAAFPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKHEAIK
DSVTHLFDRNADYVQEVKRISAEGVDIVLDCLCGDNTGKGLSLLKPLGTYILYGSSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKV
IAGFSLLNLLFKQGRAGLIRGVVEKLIGLYNQKKIKPVVDSLWALEEVKEAMQRIHDRGNIGKLILDVEKTPTPLMANDSTETSEAGEEE

--------------------------------------------------------------

>99500_99500_7_WWOX-VAT1L_WWOX_chr16_78198186_ENST00000355860_VAT1L_chr16_78005747_ENST00000302536_length(amino acids)=232AA_BP=172
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWVKEAMQRI

--------------------------------------------------------------

>99500_99500_8_WWOX-VAT1L_WWOX_chr16_78198186_ENST00000406884_VAT1L_chr16_78005747_ENST00000302536_length(amino acids)=232AA_BP=172
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWVKEAMQRI

--------------------------------------------------------------

>99500_99500_9_WWOX-VAT1L_WWOX_chr16_78198186_ENST00000408984_VAT1L_chr16_78005747_ENST00000302536_length(amino acids)=232AA_BP=172
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWVKEAMQRI

--------------------------------------------------------------

>99500_99500_10_WWOX-VAT1L_WWOX_chr16_78198186_ENST00000566780_VAT1L_chr16_78005747_ENST00000302536_length(amino acids)=232AA_BP=172
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWVKEAMQRI

--------------------------------------------------------------

>99500_99500_11_WWOX-VAT1L_WWOX_chr16_78466649_ENST00000408984_VAT1L_chr16_78005747_ENST00000302536_length(amino acids)=412AA_BP=352
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAM
TLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDIND
SLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMVKEAMQRI

--------------------------------------------------------------

>99500_99500_12_WWOX-VAT1L_WWOX_chr16_78466649_ENST00000566780_VAT1L_chr16_78005747_ENST00000302536_length(amino acids)=412AA_BP=352
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAM
TLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDIND
SLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMVKEAMQRI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:78133782/chr16:77850818)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWOXchr16:78198186chr16:78005747ENST00000355860-5616_49172.0190.0DomainWW 1
HgeneWWOXchr16:78198186chr16:78005747ENST00000355860-5657_90172.0190.0DomainWW 2
HgeneWWOXchr16:78198186chr16:78005747ENST00000406884-5616_49172.0235.0DomainWW 1
HgeneWWOXchr16:78198186chr16:78005747ENST00000406884-5657_90172.0235.0DomainWW 2
HgeneWWOXchr16:78198186chr16:78005747ENST00000408984-51016_49172.0311.6666666666667DomainWW 1
HgeneWWOXchr16:78198186chr16:78005747ENST00000408984-51057_90172.0311.6666666666667DomainWW 2
HgeneWWOXchr16:78198186chr16:78005747ENST00000566780-5916_49172.0415.0DomainWW 1
HgeneWWOXchr16:78198186chr16:78005747ENST00000566780-5957_90172.0415.0DomainWW 2
HgeneWWOXchr16:78466649chr16:78005747ENST00000408984+81016_49352.0311.6666666666667DomainWW 1
HgeneWWOXchr16:78466649chr16:78005747ENST00000408984+81057_90352.0311.6666666666667DomainWW 2
HgeneWWOXchr16:78466649chr16:78005747ENST00000566780+8916_49352.0415.0DomainWW 1
HgeneWWOXchr16:78466649chr16:78005747ENST00000566780+8957_90352.0415.0DomainWW 2
HgeneWWOXchr16:78198186chr16:78005747ENST00000355860-5650_55172.0190.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr16:78005747ENST00000406884-5650_55172.0235.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr16:78005747ENST00000408984-51050_55172.0311.6666666666667MotifNuclear localization signal
HgeneWWOXchr16:78198186chr16:78005747ENST00000566780-5950_55172.0415.0MotifNuclear localization signal
HgeneWWOXchr16:78466649chr16:78005747ENST00000408984+81050_55352.0311.6666666666667MotifNuclear localization signal
HgeneWWOXchr16:78466649chr16:78005747ENST00000566780+8950_55352.0415.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr16:78005747ENST00000355860-56131_137172.0190.0Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr16:78005747ENST00000406884-56131_137172.0235.0Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr16:78005747ENST00000408984-510131_137172.0311.6666666666667Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr16:78005747ENST00000566780-59131_137172.0415.0Nucleotide bindingNADP
HgeneWWOXchr16:78466649chr16:78005747ENST00000408984+810131_137352.0311.6666666666667Nucleotide bindingNADP
HgeneWWOXchr16:78466649chr16:78005747ENST00000566780+89131_137352.0415.0Nucleotide bindingNADP
HgeneWWOXchr16:78466649chr16:78005747ENST00000408984+810209_273352.0311.6666666666667RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78466649chr16:78005747ENST00000566780+89209_273352.0415.0RegionMediates targeting to the mitochondria

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWOXchr16:78133782chr16:77850818ENST00000355860+1616_4935.666666666666664190.0DomainWW 1
HgeneWWOXchr16:78133782chr16:77850818ENST00000355860+1657_9035.666666666666664190.0DomainWW 2
HgeneWWOXchr16:78133782chr16:77850818ENST00000402655+1516_4935.666666666666664312.0DomainWW 1
HgeneWWOXchr16:78133782chr16:77850818ENST00000402655+1557_9035.666666666666664312.0DomainWW 2
HgeneWWOXchr16:78133782chr16:77850818ENST00000406884+1616_4935.666666666666664235.0DomainWW 1
HgeneWWOXchr16:78133782chr16:77850818ENST00000406884+1657_9035.666666666666664235.0DomainWW 2
HgeneWWOXchr16:78133782chr16:77850818ENST00000408984+11016_4935.666666666666664311.6666666666667DomainWW 1
HgeneWWOXchr16:78133782chr16:77850818ENST00000408984+11057_9035.666666666666664311.6666666666667DomainWW 2
HgeneWWOXchr16:78133782chr16:77850818ENST00000566780+1916_4935.666666666666664415.0DomainWW 1
HgeneWWOXchr16:78133782chr16:77850818ENST00000566780+1957_9035.666666666666664415.0DomainWW 2
HgeneWWOXchr16:78133782chr16:77850818ENST00000569818+1116_49037.0DomainWW 1
HgeneWWOXchr16:78133782chr16:77850818ENST00000569818+1157_90037.0DomainWW 2
HgeneWWOXchr16:78198186chr16:78005747ENST00000402655-1516_490312.0DomainWW 1
HgeneWWOXchr16:78198186chr16:78005747ENST00000402655-1557_900312.0DomainWW 2
HgeneWWOXchr16:78198186chr16:78005747ENST00000569818-1116_49037.0DomainWW 1
HgeneWWOXchr16:78198186chr16:78005747ENST00000569818-1157_90037.0DomainWW 2
HgeneWWOXchr16:78466649chr16:78005747ENST00000355860+1616_490190.0DomainWW 1
HgeneWWOXchr16:78466649chr16:78005747ENST00000355860+1657_900190.0DomainWW 2
HgeneWWOXchr16:78466649chr16:78005747ENST00000402655+1516_490312.0DomainWW 1
HgeneWWOXchr16:78466649chr16:78005747ENST00000402655+1557_900312.0DomainWW 2
HgeneWWOXchr16:78466649chr16:78005747ENST00000406884+1616_490235.0DomainWW 1
HgeneWWOXchr16:78466649chr16:78005747ENST00000406884+1657_900235.0DomainWW 2
HgeneWWOXchr16:78466649chr16:78005747ENST00000569818+1116_49037.0DomainWW 1
HgeneWWOXchr16:78466649chr16:78005747ENST00000569818+1157_90037.0DomainWW 2
HgeneWWOXchr16:78133782chr16:77850818ENST00000355860+1650_5535.666666666666664190.0MotifNuclear localization signal
HgeneWWOXchr16:78133782chr16:77850818ENST00000402655+1550_5535.666666666666664312.0MotifNuclear localization signal
HgeneWWOXchr16:78133782chr16:77850818ENST00000406884+1650_5535.666666666666664235.0MotifNuclear localization signal
HgeneWWOXchr16:78133782chr16:77850818ENST00000408984+11050_5535.666666666666664311.6666666666667MotifNuclear localization signal
HgeneWWOXchr16:78133782chr16:77850818ENST00000566780+1950_5535.666666666666664415.0MotifNuclear localization signal
HgeneWWOXchr16:78133782chr16:77850818ENST00000569818+1150_55037.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr16:78005747ENST00000402655-1550_550312.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr16:78005747ENST00000569818-1150_55037.0MotifNuclear localization signal
HgeneWWOXchr16:78466649chr16:78005747ENST00000355860+1650_550190.0MotifNuclear localization signal
HgeneWWOXchr16:78466649chr16:78005747ENST00000402655+1550_550312.0MotifNuclear localization signal
HgeneWWOXchr16:78466649chr16:78005747ENST00000406884+1650_550235.0MotifNuclear localization signal
HgeneWWOXchr16:78466649chr16:78005747ENST00000569818+1150_55037.0MotifNuclear localization signal
HgeneWWOXchr16:78133782chr16:77850818ENST00000355860+16131_13735.666666666666664190.0Nucleotide bindingNADP
HgeneWWOXchr16:78133782chr16:77850818ENST00000402655+15131_13735.666666666666664312.0Nucleotide bindingNADP
HgeneWWOXchr16:78133782chr16:77850818ENST00000406884+16131_13735.666666666666664235.0Nucleotide bindingNADP
HgeneWWOXchr16:78133782chr16:77850818ENST00000408984+110131_13735.666666666666664311.6666666666667Nucleotide bindingNADP
HgeneWWOXchr16:78133782chr16:77850818ENST00000566780+19131_13735.666666666666664415.0Nucleotide bindingNADP
HgeneWWOXchr16:78133782chr16:77850818ENST00000569818+11131_137037.0Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr16:78005747ENST00000402655-15131_1370312.0Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr16:78005747ENST00000569818-11131_137037.0Nucleotide bindingNADP
HgeneWWOXchr16:78466649chr16:78005747ENST00000355860+16131_1370190.0Nucleotide bindingNADP
HgeneWWOXchr16:78466649chr16:78005747ENST00000402655+15131_1370312.0Nucleotide bindingNADP
HgeneWWOXchr16:78466649chr16:78005747ENST00000406884+16131_1370235.0Nucleotide bindingNADP
HgeneWWOXchr16:78466649chr16:78005747ENST00000569818+11131_137037.0Nucleotide bindingNADP
HgeneWWOXchr16:78133782chr16:77850818ENST00000355860+16209_27335.666666666666664190.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78133782chr16:77850818ENST00000402655+15209_27335.666666666666664312.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78133782chr16:77850818ENST00000406884+16209_27335.666666666666664235.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78133782chr16:77850818ENST00000408984+110209_27335.666666666666664311.6666666666667RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78133782chr16:77850818ENST00000566780+19209_27335.666666666666664415.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78133782chr16:77850818ENST00000569818+11209_273037.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr16:78005747ENST00000355860-56209_273172.0190.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr16:78005747ENST00000402655-15209_2730312.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr16:78005747ENST00000406884-56209_273172.0235.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr16:78005747ENST00000408984-510209_273172.0311.6666666666667RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr16:78005747ENST00000566780-59209_273172.0415.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr16:78005747ENST00000569818-11209_273037.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78466649chr16:78005747ENST00000355860+16209_2730190.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78466649chr16:78005747ENST00000402655+15209_2730312.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78466649chr16:78005747ENST00000406884+16209_2730235.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78466649chr16:78005747ENST00000569818+11209_273037.0RegionMediates targeting to the mitochondria


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
WWOX
VAT1L


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneWWOXchr16:78133782chr16:77850818ENST00000355860+16125_41435.666666666666664190.0MAPT
HgeneWWOXchr16:78133782chr16:77850818ENST00000402655+15125_41435.666666666666664312.0MAPT
HgeneWWOXchr16:78133782chr16:77850818ENST00000406884+16125_41435.666666666666664235.0MAPT
HgeneWWOXchr16:78133782chr16:77850818ENST00000408984+110125_41435.666666666666664311.6666666666667MAPT
HgeneWWOXchr16:78133782chr16:77850818ENST00000566780+19125_41435.666666666666664415.0MAPT
HgeneWWOXchr16:78133782chr16:77850818ENST00000569818+11125_414037.0MAPT
HgeneWWOXchr16:78198186chr16:78005747ENST00000355860-56125_414172.0190.0MAPT
HgeneWWOXchr16:78198186chr16:78005747ENST00000402655-15125_4140312.0MAPT
HgeneWWOXchr16:78198186chr16:78005747ENST00000406884-56125_414172.0235.0MAPT
HgeneWWOXchr16:78198186chr16:78005747ENST00000408984-510125_414172.0311.6666666666667MAPT
HgeneWWOXchr16:78198186chr16:78005747ENST00000566780-59125_414172.0415.0MAPT
HgeneWWOXchr16:78198186chr16:78005747ENST00000569818-11125_414037.0MAPT
HgeneWWOXchr16:78466649chr16:78005747ENST00000355860+16125_4140190.0MAPT
HgeneWWOXchr16:78466649chr16:78005747ENST00000402655+15125_4140312.0MAPT
HgeneWWOXchr16:78466649chr16:78005747ENST00000406884+16125_4140235.0MAPT
HgeneWWOXchr16:78466649chr16:78005747ENST00000566780+89125_414352.0415.0MAPT
HgeneWWOXchr16:78466649chr16:78005747ENST00000569818+11125_414037.0MAPT


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Related Drugs to WWOX-VAT1L


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to WWOX-VAT1L


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource