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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:XBP1-TTC28

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: XBP1-TTC28
FusionPDB ID: 99579
FusionGDB2.0 ID: 99579
HgeneTgene
Gene symbol

XBP1

TTC28

Gene ID

7494

23331

Gene nameX-box binding protein 1tetratricopeptide repeat domain 28
SynonymsTREB-5|TREB5|XBP-1|XBP2TPRBK
Cytomap

22q12.1|22q12

22q12.1

Type of geneprotein-codingprotein-coding
DescriptionX-box-binding protein 1tax-responsive element-binding protein 5tetratricopeptide repeat protein 28TPR repeat protein 28TPR repeat-containing big gene cloned at KeioTPR-containing big gene cloned at Keio
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000216037, ENST00000344347, 
ENST00000403532, ENST00000405219, 
ENST00000490475, ENST00000397906, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 13 X 7=118338 X 29 X 5=5510
# samples 1641
** MAII scorelog2(16/1183*10)=-2.88630626345243
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/5510*10)=-3.74835650395307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: XBP1 [Title/Abstract] AND TTC28 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)XBP1(29192035)-TTC28(28559587), # samples:2
XBP1(29195045)-TTC28(29025818), # samples:2
Anticipated loss of major functional domain due to fusion event.XBP1-TTC28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
XBP1-TTC28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
XBP1-TTC28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
XBP1-TTC28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
XBP1-TTC28 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXBP1

GO:0002639

positive regulation of immunoglobulin production

11460154

HgeneXBP1

GO:0008284

positive regulation of cell proliferation

25656649

HgeneXBP1

GO:0030335

positive regulation of cell migration

25656649

HgeneXBP1

GO:0035470

positive regulation of vascular wound healing

25656649

HgeneXBP1

GO:0045579

positive regulation of B cell differentiation

11460154

HgeneXBP1

GO:0045582

positive regulation of T cell differentiation

11460154

HgeneXBP1

GO:0045944

positive regulation of transcription by RNA polymerase II

8657566

HgeneXBP1

GO:0071222

cellular response to lipopolysaccharide

11460154

HgeneXBP1

GO:1900100

positive regulation of plasma cell differentiation

11460154

HgeneXBP1

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

19135031


check buttonFusion gene breakpoints across XBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TTC28 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4TGCTTCGA-2X-A9D6-01AXBP1chr22

29192035

-TTC28chr22

28559587

-
ChimerDB4TGCTTCGA-2X-A9D6XBP1chr22

29192034

-TTC28chr22

28559587

-
ChimerDB4TGCTTCGA-2X-A9D6XBP1chr22

29192035

-TTC28chr22

28559587

-
ChimerDB4TGCTTCGA-4K-AAAL-01AXBP1chr22

29195045

-TTC28chr22

29025818

-
ChimerDB4TGCTTCGA-4K-AAALXBP1chr22

29195045

-TTC28chr22

29025818

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344347XBP1chr2229192035-ENST00000397906TTC28chr2228559587-11291573070852361
ENST00000216037XBP1chr2229195045-ENST00000397906TTC28chr2229025818-119463977377402555
ENST00000405219XBP1chr2229195045-ENST00000397906TTC28chr2229025818-118202719176142507
ENST00000344347XBP1chr2229195045-ENST00000397906TTC28chr2229025818-11873324076672555
ENST00000344347XBP1chr2229192034-ENST00000397906TTC28chr2228559587-11291573070852361

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344347ENST00000397906XBP1chr2229192035-TTC28chr2228559587-0.0015251230.9984749
ENST00000216037ENST00000397906XBP1chr2229195045-TTC28chr2229025818-0.0016555580.9983444
ENST00000405219ENST00000397906XBP1chr2229195045-TTC28chr2229025818-0.0016466590.99835336
ENST00000344347ENST00000397906XBP1chr2229195045-TTC28chr2229025818-0.0015585180.9984415
ENST00000344347ENST00000397906XBP1chr2229192034-TTC28chr2228559587-0.0015251230.9984749

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99579_99579_1_XBP1-TTC28_XBP1_chr22_29192034_ENST00000344347_TTC28_chr22_28559587_ENST00000397906_length(amino acids)=2361AA_BP=0
MVVVAAAPNPADGTPKVLLLSGQPASAAGAPAGQALPLMVPAQRGASPEAASGGLPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDR
KKARMSELEQQVVDLEEENQKLLLENQLLREKTHGLVVENQELRQRLGMDALVAEEEAEAKGNEVRPVAGSAESAAGAGPVVTPPEHLPM
DSGGIDSSDSEAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNK
REEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNL
GIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAH
DRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQD
LALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDR
RLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNM
GITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAM
GSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYH
QLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQL
GRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAF
ADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKFHEHYLGENTVENSSDFQASSSVTLPTATGS
ALEQHIASVREALGVESHYSRACASSETESEAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSS
LPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGSSSNEYLYERFGLLAVPSIRSLSVQSKSHLR
KNPPTYSSSTSMAAVIGNPKLPSAVMDRWLWGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTP
SMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKLVVLGSSQESNSKVTADGVIALTRAFLAAGA
QCVLVSLWPVPVAASKMFIHAFYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQALTEILQHPERARD
ALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQCSSTLQSLLGLPNP
ALQALCKLITASETGEQLISRAVKNMVGMLHQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGK
QANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLSSIASSMSFVSKPEG
GSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSK
GSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIAVERLQRSGGQVSKS
NNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQ
LDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQSTPQH
STGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPLR

--------------------------------------------------------------

>99579_99579_2_XBP1-TTC28_XBP1_chr22_29192035_ENST00000344347_TTC28_chr22_28559587_ENST00000397906_length(amino acids)=2361AA_BP=0
MVVVAAAPNPADGTPKVLLLSGQPASAAGAPAGQALPLMVPAQRGASPEAASGGLPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDR
KKARMSELEQQVVDLEEENQKLLLENQLLREKTHGLVVENQELRQRLGMDALVAEEEAEAKGNEVRPVAGSAESAAGAGPVVTPPEHLPM
DSGGIDSSDSEAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNK
REEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNL
GIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAH
DRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQD
LALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDR
RLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNM
GITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAM
GSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYH
QLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQL
GRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAF
ADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKFHEHYLGENTVENSSDFQASSSVTLPTATGS
ALEQHIASVREALGVESHYSRACASSETESEAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSS
LPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGSSSNEYLYERFGLLAVPSIRSLSVQSKSHLR
KNPPTYSSSTSMAAVIGNPKLPSAVMDRWLWGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTP
SMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKLVVLGSSQESNSKVTADGVIALTRAFLAAGA
QCVLVSLWPVPVAASKMFIHAFYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQALTEILQHPERARD
ALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQCSSTLQSLLGLPNP
ALQALCKLITASETGEQLISRAVKNMVGMLHQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGK
QANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLSSIASSMSFVSKPEG
GSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSK
GSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIAVERLQRSGGQVSKS
NNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQ
LDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQSTPQH
STGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPLR

--------------------------------------------------------------

>99579_99579_3_XBP1-TTC28_XBP1_chr22_29195045_ENST00000216037_TTC28_chr22_29025818_ENST00000397906_length(amino acids)=2555AA_BP=0
MVVVAAAPNPADGTPKVLLLSGQPASAAGAPAGQALPLMVPAQRGASPEAASGGLPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDR
KKARMSELEQQVVDLEEEIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQ
QYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPF
VVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFS
KGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQC
HEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAED
LKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQAST
HGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYC
LGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKF
YEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQK
LKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQ
AKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGV
YQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQA
VMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHD
EALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKFHEHYLGENTVENSSDF
QASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETESEAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSL
FSNTVSPTQDGTSSLPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGSSSNEYLYERFGLLAVP
SIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWLWGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFA
THISWKLSALVLTPSMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKLVVLGSSQESNSKVTAD
GVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQ
ALTEILQHPERARDALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQ
CSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGMLHQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDL
CEVGQEEVILKTGKQANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLS
SIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQ
PGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIA
VERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQH
SGRPSPGCDSQTSQLDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQA
VHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPL

--------------------------------------------------------------

>99579_99579_4_XBP1-TTC28_XBP1_chr22_29195045_ENST00000344347_TTC28_chr22_29025818_ENST00000397906_length(amino acids)=2555AA_BP=0
MVVVAAAPNPADGTPKVLLLSGQPASAAGAPAGQALPLMVPAQRGASPEAASGGLPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDR
KKARMSELEQQVVDLEEEIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQ
QYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPF
VVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFS
KGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQC
HEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAED
LKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQAST
HGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYC
LGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKF
YEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQK
LKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQ
AKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGV
YQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQA
VMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHD
EALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKFHEHYLGENTVENSSDF
QASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETESEAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSL
FSNTVSPTQDGTSSLPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGSSSNEYLYERFGLLAVP
SIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWLWGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFA
THISWKLSALVLTPSMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKLVVLGSSQESNSKVTAD
GVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQ
ALTEILQHPERARDALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQ
CSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGMLHQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDL
CEVGQEEVILKTGKQANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLS
SIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQ
PGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIA
VERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQH
SGRPSPGCDSQTSQLDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQA
VHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPL

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>99579_99579_5_XBP1-TTC28_XBP1_chr22_29195045_ENST00000405219_TTC28_chr22_29025818_ENST00000397906_length(amino acids)=2507AA_BP=1
MGMRAPVFQALLLCGRRLVVQPLNSDMRKLKNRVAAQTARDRKKARMSELEQQVVDLEEEIPLFGADTIGQRSPDGPVLSKAEFVEKVRQ
SNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLA
QDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAY
WSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNAL
ASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELA
QELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQG
RAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFH
CSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAE
ECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVY
QELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVL
DRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELG
SLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFE
RAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRAS
ALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRG
LVLYYSLAAGYLYSWLLAPGAGIVKFHEHYLGENTVENSSDFQASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETESEAGD
IMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSSLPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGP
VGRHRQLILVLEGELYLIPFALLKGSSSNEYLYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWLWGPM
PSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTPSMDGNPASSKSSFGHPYTIPESLRVQDDASDGES
ISDCPPLQELLLTAADVLDLQLPVKLVVLGSSQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGLKASA
ALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQALTEILQHPERARDALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENK
VGGIPGWQALLTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGMLHQVL
VQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGKQANRRTVHFALQSLLSLFDSTELPKRLSLDSSSS
LESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQ
TRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTG
ESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKS
QPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQLDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQS
PAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKK

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:29192035/chr22:28559587)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXBP1chr22:29192034chr22:28559587ENST00000216037-4570_133199.66666666666666262.0DomainbZIP
HgeneXBP1chr22:29192034chr22:28559587ENST00000344347-5670_133191.0377.0DomainbZIP
HgeneXBP1chr22:29192035chr22:28559587ENST00000216037-4570_133199.66666666666666262.0DomainbZIP
HgeneXBP1chr22:29192035chr22:28559587ENST00000344347-5670_133191.0377.0DomainbZIP
HgeneXBP1chr22:29192034chr22:28559587ENST00000216037-4572_94199.66666666666666262.0RegionBasic motif
HgeneXBP1chr22:29192034chr22:28559587ENST00000216037-4575_92199.66666666666666262.0RegionNuclear localization signal (NLS)%3B in isoforms 1 and isoform 2
HgeneXBP1chr22:29192034chr22:28559587ENST00000216037-4598_133199.66666666666666262.0RegionLeucine-zipper
HgeneXBP1chr22:29192034chr22:28559587ENST00000344347-5672_94191.0377.0RegionBasic motif
HgeneXBP1chr22:29192034chr22:28559587ENST00000344347-5675_92191.0377.0RegionNuclear localization signal (NLS)%3B in isoforms 1 and isoform 2
HgeneXBP1chr22:29192034chr22:28559587ENST00000344347-5698_133191.0377.0RegionLeucine-zipper
HgeneXBP1chr22:29192035chr22:28559587ENST00000216037-4572_94199.66666666666666262.0RegionBasic motif
HgeneXBP1chr22:29192035chr22:28559587ENST00000216037-4575_92199.66666666666666262.0RegionNuclear localization signal (NLS)%3B in isoforms 1 and isoform 2
HgeneXBP1chr22:29192035chr22:28559587ENST00000216037-4598_133199.66666666666666262.0RegionLeucine-zipper
HgeneXBP1chr22:29192035chr22:28559587ENST00000344347-5672_94191.0377.0RegionBasic motif
HgeneXBP1chr22:29192035chr22:28559587ENST00000344347-5675_92191.0377.0RegionNuclear localization signal (NLS)%3B in isoforms 1 and isoform 2
HgeneXBP1chr22:29192035chr22:28559587ENST00000344347-5698_133191.0377.0RegionLeucine-zipper
HgeneXBP1chr22:29195045chr22:29025818ENST00000216037-2572_94108.0262.0RegionBasic motif
HgeneXBP1chr22:29195045chr22:29025818ENST00000216037-2575_92108.0262.0RegionNuclear localization signal (NLS)%3B in isoforms 1 and isoform 2
HgeneXBP1chr22:29195045chr22:29025818ENST00000344347-2672_94108.0377.0RegionBasic motif
HgeneXBP1chr22:29195045chr22:29025818ENST00000344347-2675_92108.0377.0RegionNuclear localization signal (NLS)%3B in isoforms 1 and isoform 2
HgeneXBP1chr22:29192034chr22:28559587ENST00000216037-451_185199.66666666666666262.0Topological domainCytoplasmic
HgeneXBP1chr22:29192034chr22:28559587ENST00000344347-561_185191.0377.0Topological domainCytoplasmic
HgeneXBP1chr22:29192035chr22:28559587ENST00000216037-451_185199.66666666666666262.0Topological domainCytoplasmic
HgeneXBP1chr22:29192035chr22:28559587ENST00000344347-561_185191.0377.0Topological domainCytoplasmic
TgeneTTC28chr22:29192034chr22:28559587ENST000003979064231948_2006311.02482.0Compositional biasNote=Ser-rich
TgeneTTC28chr22:29192034chr22:28559587ENST000003979064232201_2335311.02482.0Compositional biasNote=Ser-rich
TgeneTTC28chr22:29192035chr22:28559587ENST000003979064231948_2006311.02482.0Compositional biasNote=Ser-rich
TgeneTTC28chr22:29192035chr22:28559587ENST000003979064232201_2335311.02482.0Compositional biasNote=Ser-rich
TgeneTTC28chr22:29195045chr22:29025818ENST000003979060231948_200634.02482.0Compositional biasNote=Ser-rich
TgeneTTC28chr22:29195045chr22:29025818ENST000003979060232201_233534.02482.0Compositional biasNote=Ser-rich
TgeneTTC28chr22:29192034chr22:28559587ENST000003979064231037_1070311.02482.0RepeatNote=TPR 25
TgeneTTC28chr22:29192034chr22:28559587ENST000003979064231077_1110311.02482.0RepeatNote=TPR 26
TgeneTTC28chr22:29192034chr22:28559587ENST000003979064231117_1150311.02482.0RepeatNote=TPR 27
TgeneTTC28chr22:29192034chr22:28559587ENST000003979064231169_1202311.02482.0RepeatNote=TPR 28
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423314_347311.02482.0RepeatNote=TPR 7
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423354_387311.02482.0RepeatNote=TPR 8
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423394_427311.02482.0RepeatNote=TPR 9
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423434_467311.02482.0RepeatNote=TPR 10
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423474_507311.02482.0RepeatNote=TPR 11
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423514_547311.02482.0RepeatNote=TPR 12
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423554_587311.02482.0RepeatNote=TPR 13
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423594_627311.02482.0RepeatNote=TPR 14
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423634_667311.02482.0RepeatNote=TPR 15
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423674_707311.02482.0RepeatNote=TPR 16
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423714_747311.02482.0RepeatNote=TPR 17
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423754_787311.02482.0RepeatNote=TPR 18
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423794_827311.02482.0RepeatNote=TPR 19
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423834_867311.02482.0RepeatNote=TPR 20
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423877_910311.02482.0RepeatNote=TPR 21
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423917_950311.02482.0RepeatNote=TPR 22
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423957_990311.02482.0RepeatNote=TPR 23
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423997_1030311.02482.0RepeatNote=TPR 24
TgeneTTC28chr22:29192035chr22:28559587ENST000003979064231037_1070311.02482.0RepeatNote=TPR 25
TgeneTTC28chr22:29192035chr22:28559587ENST000003979064231077_1110311.02482.0RepeatNote=TPR 26
TgeneTTC28chr22:29192035chr22:28559587ENST000003979064231117_1150311.02482.0RepeatNote=TPR 27
TgeneTTC28chr22:29192035chr22:28559587ENST000003979064231169_1202311.02482.0RepeatNote=TPR 28
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423314_347311.02482.0RepeatNote=TPR 7
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423354_387311.02482.0RepeatNote=TPR 8
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423394_427311.02482.0RepeatNote=TPR 9
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423434_467311.02482.0RepeatNote=TPR 10
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423474_507311.02482.0RepeatNote=TPR 11
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423514_547311.02482.0RepeatNote=TPR 12
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423554_587311.02482.0RepeatNote=TPR 13
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423594_627311.02482.0RepeatNote=TPR 14
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423634_667311.02482.0RepeatNote=TPR 15
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423674_707311.02482.0RepeatNote=TPR 16
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423714_747311.02482.0RepeatNote=TPR 17
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423754_787311.02482.0RepeatNote=TPR 18
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423794_827311.02482.0RepeatNote=TPR 19
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423834_867311.02482.0RepeatNote=TPR 20
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423877_910311.02482.0RepeatNote=TPR 21
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423917_950311.02482.0RepeatNote=TPR 22
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423957_990311.02482.0RepeatNote=TPR 23
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423997_1030311.02482.0RepeatNote=TPR 24
TgeneTTC28chr22:29195045chr22:29025818ENST000003979060231037_107034.02482.0RepeatNote=TPR 25
TgeneTTC28chr22:29195045chr22:29025818ENST000003979060231077_111034.02482.0RepeatNote=TPR 26
TgeneTTC28chr22:29195045chr22:29025818ENST000003979060231117_115034.02482.0RepeatNote=TPR 27
TgeneTTC28chr22:29195045chr22:29025818ENST000003979060231169_120234.02482.0RepeatNote=TPR 28
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023126_15934.02482.0RepeatNote=TPR 3
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023196_22934.02482.0RepeatNote=TPR 4
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023234_26734.02482.0RepeatNote=TPR 5
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023274_30734.02482.0RepeatNote=TPR 6
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023314_34734.02482.0RepeatNote=TPR 7
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023354_38734.02482.0RepeatNote=TPR 8
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023394_42734.02482.0RepeatNote=TPR 9
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023434_46734.02482.0RepeatNote=TPR 10
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023474_50734.02482.0RepeatNote=TPR 11
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023514_54734.02482.0RepeatNote=TPR 12
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023554_58734.02482.0RepeatNote=TPR 13
TgeneTTC28chr22:29195045chr22:29025818ENST0000039790602358_9134.02482.0RepeatNote=TPR 1
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023594_62734.02482.0RepeatNote=TPR 14
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023634_66734.02482.0RepeatNote=TPR 15
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023674_70734.02482.0RepeatNote=TPR 16
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023714_74734.02482.0RepeatNote=TPR 17
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023754_78734.02482.0RepeatNote=TPR 18
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023794_82734.02482.0RepeatNote=TPR 19
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023834_86734.02482.0RepeatNote=TPR 20
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023877_91034.02482.0RepeatNote=TPR 21
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023917_95034.02482.0RepeatNote=TPR 22
TgeneTTC28chr22:29195045chr22:29025818ENST0000039790602393_12534.02482.0RepeatNote=TPR 2
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023957_99034.02482.0RepeatNote=TPR 23
TgeneTTC28chr22:29195045chr22:29025818ENST00000397906023997_103034.02482.0RepeatNote=TPR 24

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXBP1chr22:29195045chr22:29025818ENST00000216037-2570_133108.0262.0DomainbZIP
HgeneXBP1chr22:29195045chr22:29025818ENST00000344347-2670_133108.0377.0DomainbZIP
HgeneXBP1chr22:29192034chr22:28559587ENST00000216037-45235_261199.66666666666666262.0RegionNecessary for the translational pausing of its own mRNA
HgeneXBP1chr22:29192034chr22:28559587ENST00000344347-56235_261191.0377.0RegionNecessary for the translational pausing of its own mRNA
HgeneXBP1chr22:29192035chr22:28559587ENST00000216037-45235_261199.66666666666666262.0RegionNecessary for the translational pausing of its own mRNA
HgeneXBP1chr22:29192035chr22:28559587ENST00000344347-56235_261191.0377.0RegionNecessary for the translational pausing of its own mRNA
HgeneXBP1chr22:29195045chr22:29025818ENST00000216037-25235_261108.0262.0RegionNecessary for the translational pausing of its own mRNA
HgeneXBP1chr22:29195045chr22:29025818ENST00000216037-2598_133108.0262.0RegionLeucine-zipper
HgeneXBP1chr22:29195045chr22:29025818ENST00000344347-26235_261108.0377.0RegionNecessary for the translational pausing of its own mRNA
HgeneXBP1chr22:29195045chr22:29025818ENST00000344347-2698_133108.0377.0RegionLeucine-zipper
HgeneXBP1chr22:29192034chr22:28559587ENST00000216037-45204_261199.66666666666666262.0Topological domainLumenal
HgeneXBP1chr22:29192034chr22:28559587ENST00000344347-56204_261191.0377.0Topological domainLumenal
HgeneXBP1chr22:29192035chr22:28559587ENST00000216037-45204_261199.66666666666666262.0Topological domainLumenal
HgeneXBP1chr22:29192035chr22:28559587ENST00000344347-56204_261191.0377.0Topological domainLumenal
HgeneXBP1chr22:29195045chr22:29025818ENST00000216037-251_185108.0262.0Topological domainCytoplasmic
HgeneXBP1chr22:29195045chr22:29025818ENST00000216037-25204_261108.0262.0Topological domainLumenal
HgeneXBP1chr22:29195045chr22:29025818ENST00000344347-261_185108.0377.0Topological domainCytoplasmic
HgeneXBP1chr22:29195045chr22:29025818ENST00000344347-26204_261108.0377.0Topological domainLumenal
HgeneXBP1chr22:29192034chr22:28559587ENST00000216037-45186_203199.66666666666666262.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneXBP1chr22:29192034chr22:28559587ENST00000344347-56186_203191.0377.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneXBP1chr22:29192035chr22:28559587ENST00000216037-45186_203199.66666666666666262.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneXBP1chr22:29192035chr22:28559587ENST00000344347-56186_203191.0377.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneXBP1chr22:29195045chr22:29025818ENST00000216037-25186_203108.0262.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneXBP1chr22:29195045chr22:29025818ENST00000344347-26186_203108.0377.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423126_159311.02482.0RepeatNote=TPR 3
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423196_229311.02482.0RepeatNote=TPR 4
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423234_267311.02482.0RepeatNote=TPR 5
TgeneTTC28chr22:29192034chr22:28559587ENST00000397906423274_307311.02482.0RepeatNote=TPR 6
TgeneTTC28chr22:29192034chr22:28559587ENST0000039790642358_91311.02482.0RepeatNote=TPR 1
TgeneTTC28chr22:29192034chr22:28559587ENST0000039790642393_125311.02482.0RepeatNote=TPR 2
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423126_159311.02482.0RepeatNote=TPR 3
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423196_229311.02482.0RepeatNote=TPR 4
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423234_267311.02482.0RepeatNote=TPR 5
TgeneTTC28chr22:29192035chr22:28559587ENST00000397906423274_307311.02482.0RepeatNote=TPR 6
TgeneTTC28chr22:29192035chr22:28559587ENST0000039790642358_91311.02482.0RepeatNote=TPR 1
TgeneTTC28chr22:29192035chr22:28559587ENST0000039790642393_125311.02482.0RepeatNote=TPR 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
XBP1_pLDDT.png
all structure
all structure
TTC28_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
XBP1
TTC28


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to XBP1-TTC28


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to XBP1-TTC28


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource