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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:XPO1-USP34

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: XPO1-USP34
FusionPDB ID: 99668
FusionGDB2.0 ID: 99668
HgeneTgene
Gene symbol

XPO1

USP34

Gene ID

7514

9736

Gene nameexportin 1ubiquitin specific peptidase 34
SynonymsCRM-1|CRM1|emb|exp1-
Cytomap

2p15

2p15

Type of geneprotein-codingprotein-coding
Descriptionexportin-1chromosome region maintenance 1 homologchromosome region maintenance 1 protein homologexportin 1 (CRM1 homolog, yeast)exportin-1 (required for chromosome region maintenance)ubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000401558, ENST00000404992, 
ENST00000406957, ENST00000481214, 
ENST00000472689, ENST00000398571, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 15 X 9=162010 X 16 X 4=640
# samples 1915
** MAII scorelog2(19/1620*10)=-3.09192248944104
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/640*10)=-2.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: XPO1 [Title/Abstract] AND USP34 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)USP34(61597455)-XPO1(61761038), # samples:1
USP34(61632843)-XPO1(61711240), # samples:1
USP34(61697785)-XPO1(61729445), # samples:1
XPO1(61753554)-USP34(61434021), # samples:1
XPO1(61749746)-USP34(61448741), # samples:1
XPO1(61749746)-USP34(61449798), # samples:1
XPO1(61749746)-USP34(61647968), # samples:1
XPO1(61749746)-USP34(61528589), # samples:1
Anticipated loss of major functional domain due to fusion event.XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
USP34-XPO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
USP34-XPO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
XPO1-USP34 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
USP34-XPO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
USP34-XPO1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
USP34-XPO1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
USP34-XPO1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
USP34-XPO1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXPO1

GO:0006611

protein export from nucleus

22250199

TgeneUSP34

GO:0016579

protein deubiquitination

14715245

TgeneUSP34

GO:0071108

protein K48-linked deubiquitination

21383061

TgeneUSP34

GO:0090263

positive regulation of canonical Wnt signaling pathway

21383061


check buttonFusion gene breakpoints across XPO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across USP34 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A2BK-01AXPO1chr2

61749746

-USP34chr2

61647968

-
ChimerDB4BRCATCGA-AC-A8OQ-01AXPO1chr2

61749746

-USP34chr2

61448741

-
ChimerDB4BRCATCGA-AC-A8OQ-01AXPO1chr2

61749746

-USP34chr2

61449798

-
ChimerDB4GBMTCGA-27-2521-01AXPO1chr2

61749746

-USP34chr2

61528589

-
ChimerDB4OVTCGA-24-1422XPO1chr2

61753554

-USP34chr2

61434021

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000401558XPO1chr261749746-ENST00000398571USP34chr261448741-4515102910503875941
ENST00000404992XPO1chr261749746-ENST00000398571USP34chr261448741-41947087293554941
ENST00000401558XPO1chr261749746-ENST00000398571USP34chr261449798-4560102910383920960
ENST00000404992XPO1chr261749746-ENST00000398571USP34chr261449798-42397087173599960

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000401558ENST00000398571XPO1chr261749746-USP34chr261448741-0.0003413260.9996587
ENST00000404992ENST00000398571XPO1chr261749746-USP34chr261448741-0.000265710.9997342
ENST00000401558ENST00000398571XPO1chr261749746-USP34chr261449798-0.0002403250.99975973
ENST00000404992ENST00000398571XPO1chr261749746-USP34chr261449798-0.0002053860.99979466

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99668_99668_1_XPO1-USP34_XPO1_chr2_61749746_ENST00000401558_USP34_chr2_61448741_ENST00000398571_length(amino acids)=941AA_BP=
MLTMLMEFAGGPPGMPPFASYILQRIWEVIEYNPSQCLDWLAVQTPRNKLAHSWVLQNMENWVERFLLAHNYPRVRTSAAYLLVSLIPSN
SFRQMFRSTRSLHIPTRDLPLSPDTTVVLHQVYNVLLGLLSRAKLYVDAAVHGTTKLVPYFSFMTYCLISKTEKLMFSTYFMDLWNLFQP
KLSEPAIATNHNKQALLSFWYNVCADCPENIRLIVQNPVVTKNIAFNYILADHDDQDVVLFNRGMLPAYYGILRLCCEQSPAFTRQLASH
QNIQWAFKNLTPHASQYPGAVEELFNLMQLFIAQRPDMREEELEDIKQFKKTTISCYLRCLDGRSCWTTLISAFRILLESDEDRLLVVFN
RGLILMTESFNTLHMMYHEATACHVTGDLVELLSIFLSVLKSTRPYLQRKDVKQALIQWQERIEFAHKLLTLLNSYSPPELRNACIDVLK
ELVLLSPHDFLHTLVPFLQHNHCTYHHSNIPMSLGPYFPCRENIKLIGGKSNIRPPRPELNMCLLPTMVETSKGKDDVYDRMLLDYFFSY
HQFIHLLCRVAINCEKFTETLVKLSVLVAYEGLPLHLALFPKLWTELCQTQSAMSKNCIKLLCEDPVFAEYIKCILMDERTFLNNNIVYT
FMTHFLLKVQSQVFSEANCANLISTLITNLISQYQNLQSDFSNRVEISKASASLNGDLRALALLLSVHTPKQLNPALIPTLQELLSKCRT
CLQQRNSLQEQEAKERKTKDDEGATPIKRRRVSSDEEHTVDSCISDMKTETREVLTPTSTSDNETRDSSIIDPGTEQDLPSPENSSVKEY
RMEVPSSFSEDMSNIRSQHAEEQSNNGRYDDCKEFKDLHCSKDSTLAEEESEFPSTSISAVLSDLADLRSCDGQALPSQDPEVALSLSCG

--------------------------------------------------------------

>99668_99668_2_XPO1-USP34_XPO1_chr2_61749746_ENST00000401558_USP34_chr2_61449798_ENST00000398571_length(amino acids)=960AA_BP=
MLFTSIAKLTPEAANPFFKLLTMLMEFAGGPPGMPPFASYILQRIWEVIEYNPSQCLDWLAVQTPRNKLAHSWVLQNMENWVERFLLAHN
YPRVRTSAAYLLVSLIPSNSFRQMFRSTRSLHIPTRDLPLSPDTTVVLHQVYNVLLGLLSRAKLYVDAAVHGTTKLVPYFSFMTYCLISK
TEKLMFSTYFMDLWNLFQPKLSEPAIATNHNKQALLSFWYNVCADCPENIRLIVQNPVVTKNIAFNYILADHDDQDVVLFNRGMLPAYYG
ILRLCCEQSPAFTRQLASHQNIQWAFKNLTPHASQYPGAVEELFNLMQLFIAQRPDMREEELEDIKQFKKTTISCYLRCLDGRSCWTTLI
SAFRILLESDEDRLLVVFNRGLILMTESFNTLHMMYHEATACHVTGDLVELLSIFLSVLKSTRPYLQRKDVKQALIQWQERIEFAHKLLT
LLNSYSPPELRNACIDVLKELVLLSPHDFLHTLVPFLQHNHCTYHHSNIPMSLGPYFPCRENIKLIGGKSNIRPPRPELNMCLLPTMVET
SKGKDDVYDRMLLDYFFSYHQFIHLLCRVAINCEKFTETLVKLSVLVAYEGLPLHLALFPKLWTELCQTQSAMSKNCIKLLCEDPVFAEY
IKCILMDERTFLNNNIVYTFMTHFLLKVQSQVFSEANCANLISTLITNLISQYQNLQSDFSNRVEISKASASLNGDLRALALLLSVHTPK
QLNPALIPTLQELLSKCRTCLQQRNSLQEQEAKERKTKDDEGATPIKRRRVSSDEEHTVDSCISDMKTETREVLTPTSTSDNETRDSSII
DPGTEQDLPSPENSSVKEYRMEVPSSFSEDMSNIRSQHAEEQSNNGRYDDCKEFKDLHCSKDSTLAEEESEFPSTSISAVLSDLADLRSC

--------------------------------------------------------------

>99668_99668_3_XPO1-USP34_XPO1_chr2_61749746_ENST00000404992_USP34_chr2_61448741_ENST00000398571_length(amino acids)=941AA_BP=
MLTMLMEFAGGPPGMPPFASYILQRIWEVIEYNPSQCLDWLAVQTPRNKLAHSWVLQNMENWVERFLLAHNYPRVRTSAAYLLVSLIPSN
SFRQMFRSTRSLHIPTRDLPLSPDTTVVLHQVYNVLLGLLSRAKLYVDAAVHGTTKLVPYFSFMTYCLISKTEKLMFSTYFMDLWNLFQP
KLSEPAIATNHNKQALLSFWYNVCADCPENIRLIVQNPVVTKNIAFNYILADHDDQDVVLFNRGMLPAYYGILRLCCEQSPAFTRQLASH
QNIQWAFKNLTPHASQYPGAVEELFNLMQLFIAQRPDMREEELEDIKQFKKTTISCYLRCLDGRSCWTTLISAFRILLESDEDRLLVVFN
RGLILMTESFNTLHMMYHEATACHVTGDLVELLSIFLSVLKSTRPYLQRKDVKQALIQWQERIEFAHKLLTLLNSYSPPELRNACIDVLK
ELVLLSPHDFLHTLVPFLQHNHCTYHHSNIPMSLGPYFPCRENIKLIGGKSNIRPPRPELNMCLLPTMVETSKGKDDVYDRMLLDYFFSY
HQFIHLLCRVAINCEKFTETLVKLSVLVAYEGLPLHLALFPKLWTELCQTQSAMSKNCIKLLCEDPVFAEYIKCILMDERTFLNNNIVYT
FMTHFLLKVQSQVFSEANCANLISTLITNLISQYQNLQSDFSNRVEISKASASLNGDLRALALLLSVHTPKQLNPALIPTLQELLSKCRT
CLQQRNSLQEQEAKERKTKDDEGATPIKRRRVSSDEEHTVDSCISDMKTETREVLTPTSTSDNETRDSSIIDPGTEQDLPSPENSSVKEY
RMEVPSSFSEDMSNIRSQHAEEQSNNGRYDDCKEFKDLHCSKDSTLAEEESEFPSTSISAVLSDLADLRSCDGQALPSQDPEVALSLSCG

--------------------------------------------------------------

>99668_99668_4_XPO1-USP34_XPO1_chr2_61749746_ENST00000404992_USP34_chr2_61449798_ENST00000398571_length(amino acids)=960AA_BP=
MLFTSIAKLTPEAANPFFKLLTMLMEFAGGPPGMPPFASYILQRIWEVIEYNPSQCLDWLAVQTPRNKLAHSWVLQNMENWVERFLLAHN
YPRVRTSAAYLLVSLIPSNSFRQMFRSTRSLHIPTRDLPLSPDTTVVLHQVYNVLLGLLSRAKLYVDAAVHGTTKLVPYFSFMTYCLISK
TEKLMFSTYFMDLWNLFQPKLSEPAIATNHNKQALLSFWYNVCADCPENIRLIVQNPVVTKNIAFNYILADHDDQDVVLFNRGMLPAYYG
ILRLCCEQSPAFTRQLASHQNIQWAFKNLTPHASQYPGAVEELFNLMQLFIAQRPDMREEELEDIKQFKKTTISCYLRCLDGRSCWTTLI
SAFRILLESDEDRLLVVFNRGLILMTESFNTLHMMYHEATACHVTGDLVELLSIFLSVLKSTRPYLQRKDVKQALIQWQERIEFAHKLLT
LLNSYSPPELRNACIDVLKELVLLSPHDFLHTLVPFLQHNHCTYHHSNIPMSLGPYFPCRENIKLIGGKSNIRPPRPELNMCLLPTMVET
SKGKDDVYDRMLLDYFFSYHQFIHLLCRVAINCEKFTETLVKLSVLVAYEGLPLHLALFPKLWTELCQTQSAMSKNCIKLLCEDPVFAEY
IKCILMDERTFLNNNIVYTFMTHFLLKVQSQVFSEANCANLISTLITNLISQYQNLQSDFSNRVEISKASASLNGDLRALALLLSVHTPK
QLNPALIPTLQELLSKCRTCLQQRNSLQEQEAKERKTKDDEGATPIKRRRVSSDEEHTVDSCISDMKTETREVLTPTSTSDNETRDSSII
DPGTEQDLPSPENSSVKEYRMEVPSSFSEDMSNIRSQHAEEQSNNGRYDDCKEFKDLHCSKDSTLAEEESEFPSTSISAVLSDLADLRSC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:61597455/chr2:61761038)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-42546_112100.333333333333331072.0DomainImportin N-terminal
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-42546_112100.333333333333331072.0DomainImportin N-terminal
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-52646_112100.333333333333331072.0DomainImportin N-terminal
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-42546_112100.333333333333331072.0DomainImportin N-terminal
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-42546_112100.333333333333331072.0DomainImportin N-terminal
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-52646_112100.333333333333331072.0DomainImportin N-terminal
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-4251_679100.333333333333331072.0RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-425411_414100.333333333333331072.0RegionNote=Necessary for HTLV-1 Rex multimerization
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-4251_679100.333333333333331072.0RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-425411_414100.333333333333331072.0RegionNote=Necessary for HTLV-1 Rex multimerization
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-5261_679100.333333333333331072.0RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-526411_414100.333333333333331072.0RegionNote=Necessary for HTLV-1 Rex multimerization
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-4251_679100.333333333333331072.0RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-425411_414100.333333333333331072.0RegionNote=Necessary for HTLV-1 Rex multimerization
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-4251_679100.333333333333331072.0RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-425411_414100.333333333333331072.0RegionNote=Necessary for HTLV-1 Rex multimerization
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-5261_679100.333333333333331072.0RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-526411_414100.333333333333331072.0RegionNote=Necessary for HTLV-1 Rex multimerization
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-4251002_1039100.333333333333331072.0RepeatNote=HEAT 10
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-425217_240100.333333333333331072.0RepeatNote=HEAT 1
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-425241_277100.333333333333331072.0RepeatNote=HEAT 2
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-425354_472100.333333333333331072.0RepeatNote=HEAT 3
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-425515_553100.333333333333331072.0RepeatNote=HEAT 4
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-425560_597100.333333333333331072.0RepeatNote=HEAT 5
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-425602_639100.333333333333331072.0RepeatNote=HEAT 6
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-425775_813100.333333333333331072.0RepeatNote=HEAT 7
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-425885_916100.333333333333331072.0RepeatNote=HEAT 8
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-425917_954100.333333333333331072.0RepeatNote=HEAT 9
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-4251002_1039100.333333333333331072.0RepeatNote=HEAT 10
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-425217_240100.333333333333331072.0RepeatNote=HEAT 1
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-425241_277100.333333333333331072.0RepeatNote=HEAT 2
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-425354_472100.333333333333331072.0RepeatNote=HEAT 3
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-425515_553100.333333333333331072.0RepeatNote=HEAT 4
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-425560_597100.333333333333331072.0RepeatNote=HEAT 5
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-425602_639100.333333333333331072.0RepeatNote=HEAT 6
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-425775_813100.333333333333331072.0RepeatNote=HEAT 7
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-425885_916100.333333333333331072.0RepeatNote=HEAT 8
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-425917_954100.333333333333331072.0RepeatNote=HEAT 9
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-5261002_1039100.333333333333331072.0RepeatNote=HEAT 10
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-526217_240100.333333333333331072.0RepeatNote=HEAT 1
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-526241_277100.333333333333331072.0RepeatNote=HEAT 2
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-526354_472100.333333333333331072.0RepeatNote=HEAT 3
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-526515_553100.333333333333331072.0RepeatNote=HEAT 4
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-526560_597100.333333333333331072.0RepeatNote=HEAT 5
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-526602_639100.333333333333331072.0RepeatNote=HEAT 6
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-526775_813100.333333333333331072.0RepeatNote=HEAT 7
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-526885_916100.333333333333331072.0RepeatNote=HEAT 8
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-526917_954100.333333333333331072.0RepeatNote=HEAT 9
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-4251002_1039100.333333333333331072.0RepeatNote=HEAT 10
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-425217_240100.333333333333331072.0RepeatNote=HEAT 1
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-425241_277100.333333333333331072.0RepeatNote=HEAT 2
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-425354_472100.333333333333331072.0RepeatNote=HEAT 3
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-425515_553100.333333333333331072.0RepeatNote=HEAT 4
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-425560_597100.333333333333331072.0RepeatNote=HEAT 5
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-425602_639100.333333333333331072.0RepeatNote=HEAT 6
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-425775_813100.333333333333331072.0RepeatNote=HEAT 7
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-425885_916100.333333333333331072.0RepeatNote=HEAT 8
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-425917_954100.333333333333331072.0RepeatNote=HEAT 9
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-4251002_1039100.333333333333331072.0RepeatNote=HEAT 10
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-425217_240100.333333333333331072.0RepeatNote=HEAT 1
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-425241_277100.333333333333331072.0RepeatNote=HEAT 2
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-425354_472100.333333333333331072.0RepeatNote=HEAT 3
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-425515_553100.333333333333331072.0RepeatNote=HEAT 4
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-425560_597100.333333333333331072.0RepeatNote=HEAT 5
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-425602_639100.333333333333331072.0RepeatNote=HEAT 6
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-425775_813100.333333333333331072.0RepeatNote=HEAT 7
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-425885_916100.333333333333331072.0RepeatNote=HEAT 8
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-425917_954100.333333333333331072.0RepeatNote=HEAT 9
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-5261002_1039100.333333333333331072.0RepeatNote=HEAT 10
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-526217_240100.333333333333331072.0RepeatNote=HEAT 1
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-526241_277100.333333333333331072.0RepeatNote=HEAT 2
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-526354_472100.333333333333331072.0RepeatNote=HEAT 3
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-526515_553100.333333333333331072.0RepeatNote=HEAT 4
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-526560_597100.333333333333331072.0RepeatNote=HEAT 5
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-526602_639100.333333333333331072.0RepeatNote=HEAT 6
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-526775_813100.333333333333331072.0RepeatNote=HEAT 7
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-526885_916100.333333333333331072.0RepeatNote=HEAT 8
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-526917_954100.333333333333331072.0RepeatNote=HEAT 9
TgeneUSP34chr2:61749746chr2:61448741ENST0000039857164801894_22392598.03547.0DomainNote=USP
TgeneUSP34chr2:61749746chr2:61449798ENST0000039857163801894_22392583.03547.0DomainNote=USP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
XPO1
USP34


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-425800_820100.333333333333331072.0HIV-1 Rev
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-425800_820100.333333333333331072.0HIV-1 Rev
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-526800_820100.333333333333331072.0HIV-1 Rev
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-425800_820100.333333333333331072.0HIV-1 Rev
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-425800_820100.333333333333331072.0HIV-1 Rev
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-526800_820100.333333333333331072.0HIV-1 Rev
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-425327_450100.333333333333331072.0Ran and nuclear export complex formation
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-425327_450100.333333333333331072.0Ran and nuclear export complex formation
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-526327_450100.333333333333331072.0Ran and nuclear export complex formation
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-425327_450100.333333333333331072.0Ran and nuclear export complex formation
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-425327_450100.333333333333331072.0Ran and nuclear export complex formation
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-526327_450100.333333333333331072.0Ran and nuclear export complex formation
HgeneXPO1chr2:61749746chr2:61448741ENST00000401558-425411_481100.333333333333331072.0RANBP3
HgeneXPO1chr2:61749746chr2:61448741ENST00000404992-425411_481100.333333333333331072.0RANBP3
HgeneXPO1chr2:61749746chr2:61448741ENST00000406957-526411_481100.333333333333331072.0RANBP3
HgeneXPO1chr2:61749746chr2:61449798ENST00000401558-425411_481100.333333333333331072.0RANBP3
HgeneXPO1chr2:61749746chr2:61449798ENST00000404992-425411_481100.333333333333331072.0RANBP3
HgeneXPO1chr2:61749746chr2:61449798ENST00000406957-526411_481100.333333333333331072.0RANBP3


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Related Drugs to XPO1-USP34


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to XPO1-USP34


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource