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Fusion Protein:BNIP3-ABI1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: BNIP3-ABI1 | FusionPDB ID: 9984 | FusionGDB2.0 ID: 9984 | Hgene | Tgene | Gene symbol | BNIP3 | ABI1 | Gene ID | 664 | 10006 |
| Gene name | BCL2 interacting protein 3 | abl interactor 1 | |
| Synonyms | NIP3 | ABI-1|ABLBP4|E3B1|NAP1BP|SSH3BP|SSH3BP1 | |
| Cytomap | 10q26.3 | 10p12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3BCL2/adenovirus E1B 19kDa interacting protein 3BCL2/adenovirus E1B interacting protein 3nineteen kD interacting protein-3 | abl interactor 1Abelson interactor 1Abl-interactor protein 1 longabl-binding protein 4eps8 SH3 domain-binding proteininteractor protein AblBP4nap1 binding proteinspectrin SH3 domain-binding protein 1 | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | O60238 | Q8IZP0 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000368636, ENST00000540159, | ENST00000473481, ENST00000346832, ENST00000355394, ENST00000359188, ENST00000376134, ENST00000376137, ENST00000376138, ENST00000376139, ENST00000376140, ENST00000376142, ENST00000376160, ENST00000376166, ENST00000376170, ENST00000490841, ENST00000536334, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 3 X 3 X 3=27 | 14 X 8 X 5=560 |
| # samples | 3 | 13 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/560*10)=-2.10691520391651 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: BNIP3 [Title/Abstract] AND ABI1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | BNIP3(133784141)-ABI1(27054247), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | BNIP3-ABI1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BNIP3-ABI1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BNIP3-ABI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BNIP3-ABI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BNIP3 | GO:0008626 | granzyme-mediated apoptotic signaling pathway | 9396766 |
| Hgene | BNIP3 | GO:0010637 | negative regulation of mitochondrial fusion | 20436456 |
| Hgene | BNIP3 | GO:0043065 | positive regulation of apoptotic process | 9973195|10381623 |
| Hgene | BNIP3 | GO:0043068 | positive regulation of programmed cell death | 10891486 |
| Hgene | BNIP3 | GO:0043243 | positive regulation of protein complex disassembly | 20436456 |
| Hgene | BNIP3 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process | 20436456 |
| Hgene | BNIP3 | GO:0045837 | negative regulation of membrane potential | 10891486 |
| Hgene | BNIP3 | GO:0046902 | regulation of mitochondrial membrane permeability | 10891486 |
| Hgene | BNIP3 | GO:0051607 | defense response to virus | 9973195 |
| Hgene | BNIP3 | GO:0072593 | reactive oxygen species metabolic process | 10891486 |
| Hgene | BNIP3 | GO:0090141 | positive regulation of mitochondrial fission | 20436456 |
| Hgene | BNIP3 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 20436456 |
| Hgene | BNIP3 | GO:0097345 | mitochondrial outer membrane permeabilization | 18371312 |
| Tgene | ABI1 | GO:0018108 | peptidyl-tyrosine phosphorylation | 17101133 |
| Fusion gene breakpoints across BNIP3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ABI1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-36-1568 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000376170 | ABI1 | chr10 | 27054247 | - | 3278 | 664 | 23 | 1300 | 425 |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000359188 | ABI1 | chr10 | 27054247 | - | 3365 | 664 | 23 | 1387 | 454 |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000376142 | ABI1 | chr10 | 27054247 | - | 3449 | 664 | 23 | 1471 | 482 |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000376139 | ABI1 | chr10 | 27054247 | - | 3368 | 664 | 23 | 1390 | 455 |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000376160 | ABI1 | chr10 | 27054247 | - | 3365 | 664 | 23 | 1387 | 454 |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000376166 | ABI1 | chr10 | 27054247 | - | 3278 | 664 | 23 | 1300 | 425 |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000376138 | ABI1 | chr10 | 27054247 | - | 3281 | 664 | 23 | 1303 | 426 |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000355394 | ABI1 | chr10 | 27054247 | - | 3446 | 664 | 23 | 1471 | 482 |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000490841 | ABI1 | chr10 | 27054247 | - | 3101 | 664 | 23 | 1126 | 367 |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000376137 | ABI1 | chr10 | 27054247 | - | 3188 | 664 | 23 | 1213 | 396 |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000346832 | ABI1 | chr10 | 27054247 | - | 3359 | 664 | 23 | 1384 | 453 |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000536334 | ABI1 | chr10 | 27054247 | - | 3101 | 664 | 23 | 1126 | 367 |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000376134 | ABI1 | chr10 | 27054247 | - | 3365 | 664 | 23 | 1390 | 455 |
| ENST00000368636 | BNIP3 | chr10 | 133784141 | - | ENST00000376140 | ABI1 | chr10 | 27054247 | - | 1391 | 664 | 23 | 1390 | 456 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000368636 | ENST00000376170 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.000233622 | 0.9997664 |
| ENST00000368636 | ENST00000359188 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.000156013 | 0.99984396 |
| ENST00000368636 | ENST00000376142 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.000183307 | 0.9998167 |
| ENST00000368636 | ENST00000376139 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.000205328 | 0.99979466 |
| ENST00000368636 | ENST00000376160 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.000156013 | 0.99984396 |
| ENST00000368636 | ENST00000376166 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.000233622 | 0.9997664 |
| ENST00000368636 | ENST00000376138 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.00022024 | 0.99977976 |
| ENST00000368636 | ENST00000355394 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.000184966 | 0.99981505 |
| ENST00000368636 | ENST00000490841 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.000145421 | 0.99985456 |
| ENST00000368636 | ENST00000376137 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.000144798 | 0.99985516 |
| ENST00000368636 | ENST00000346832 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.000139894 | 0.99986005 |
| ENST00000368636 | ENST00000536334 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.000145421 | 0.99985456 |
| ENST00000368636 | ENST00000376134 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.00020641 | 0.9997936 |
| ENST00000368636 | ENST00000376140 | BNIP3 | chr10 | 133784141 | - | ABI1 | chr10 | 27054247 | - | 0.0019791 | 0.9980209 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >9984_9984_1_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000346832_length(amino acids)=453AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPENISVPPPSGAPPAPPLAPLLPV STVIAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPPPPP PPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMH -------------------------------------------------------------- >9984_9984_2_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000355394_length(amino acids)=482AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPENISVPPPSGAPPAPPLAPLLPV STVIAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQ ENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVI -------------------------------------------------------------- >9984_9984_3_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000359188_length(amino acids)=454AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAPGSAPGSQYGTMTRQISRHNST TSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPP PPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIM -------------------------------------------------------------- >9984_9984_4_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000376134_length(amino acids)=455AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNS TTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPP PPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI -------------------------------------------------------------- >9984_9984_5_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000376137_length(amino acids)=396AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPVSIAPPPPPMPQLTPQIPLTGFV ARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAI -------------------------------------------------------------- >9984_9984_6_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000376138_length(amino acids)=426AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNS TTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAW -------------------------------------------------------------- >9984_9984_7_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000376139_length(amino acids)=455AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNS TTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPP PPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI -------------------------------------------------------------- >9984_9984_8_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000376140_length(amino acids)=456AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNS TTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPP PPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI -------------------------------------------------------------- >9984_9984_9_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000376142_length(amino acids)=482AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPENISVPPPSGAPPAPPLAPLLPV STVIAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQ ENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVI -------------------------------------------------------------- >9984_9984_10_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000376160_length(amino acids)=454AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAPGSAPGSQYGTMTRQISRHNST TSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPP PPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIM -------------------------------------------------------------- >9984_9984_11_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000376166_length(amino acids)=425AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAPGSAPGSQYGTMTRQISRHNST TSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWA -------------------------------------------------------------- >9984_9984_12_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000376170_length(amino acids)=425AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAPGSAPGSQYGTMTRQISRHNST TSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWA -------------------------------------------------------------- >9984_9984_13_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000490841_length(amino acids)=367AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPVADSPTPPPPPPPDDIPMFDDSP PPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE -------------------------------------------------------------- >9984_9984_14_BNIP3-ABI1_BNIP3_chr10_133784141_ENST00000368636_ABI1_chr10_27054247_ENST00000536334_length(amino acids)=367AA_BP=214 MGRGAPTSAFPPPAAEAHPAARRGLRSPQLPSGAMSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGR SSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMR NTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPVADSPTPPPPPPPDDIPMFDDSP PPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:133784141/chr10:27054247) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BNIP3 | ABI1 |
| FUNCTION: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. | FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000346832 | 6 | 12 | 260_418 | 256.6666666666667 | 497.0 | Compositional bias | Note=Pro-rich | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000359188 | 5 | 11 | 260_418 | 239.66666666666666 | 481.0 | Compositional bias | Note=Pro-rich | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376138 | 5 | 10 | 260_418 | 239.66666666666666 | 453.0 | Compositional bias | Note=Pro-rich | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376139 | 4 | 10 | 260_418 | 234.66666666666666 | 477.0 | Compositional bias | Note=Pro-rich | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376140 | 5 | 11 | 260_418 | 239.66666666666666 | 482.0 | Compositional bias | Note=Pro-rich | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376142 | 5 | 12 | 260_418 | 239.66666666666666 | 509.0 | Compositional bias | Note=Pro-rich | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376166 | 4 | 9 | 260_418 | 234.66666666666666 | 447.0 | Compositional bias | Note=Pro-rich | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376170 | 5 | 10 | 260_418 | 239.66666666666666 | 452.0 | Compositional bias | Note=Pro-rich | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000490841 | 3 | 7 | 260_418 | 175.66666666666666 | 330.0 | Compositional bias | Note=Pro-rich | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000346832 | 6 | 12 | 446_505 | 256.6666666666667 | 497.0 | Domain | SH3 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000359188 | 5 | 11 | 446_505 | 239.66666666666666 | 481.0 | Domain | SH3 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376138 | 5 | 10 | 446_505 | 239.66666666666666 | 453.0 | Domain | SH3 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376139 | 4 | 10 | 446_505 | 234.66666666666666 | 477.0 | Domain | SH3 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376140 | 5 | 11 | 446_505 | 239.66666666666666 | 482.0 | Domain | SH3 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376142 | 5 | 12 | 446_505 | 239.66666666666666 | 509.0 | Domain | SH3 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376166 | 4 | 9 | 446_505 | 234.66666666666666 | 447.0 | Domain | SH3 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376170 | 5 | 10 | 446_505 | 239.66666666666666 | 452.0 | Domain | SH3 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000490841 | 3 | 7 | 446_505 | 175.66666666666666 | 330.0 | Domain | SH3 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BNIP3 | chr10:133784141 | chr10:27054247 | ENST00000368636 | - | 5 | 6 | 165_190 | 179.66666666666666 | 195.0 | Motif | Note=BH3 |
| Hgene | BNIP3 | chr10:133784141 | chr10:27054247 | ENST00000368636 | - | 5 | 6 | 229_249 | 179.66666666666666 | 195.0 | Transmembrane | Helical |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000346832 | 6 | 12 | 45_107 | 256.6666666666667 | 497.0 | Domain | t-SNARE coiled-coil homology | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000359188 | 5 | 11 | 45_107 | 239.66666666666666 | 481.0 | Domain | t-SNARE coiled-coil homology | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376138 | 5 | 10 | 45_107 | 239.66666666666666 | 453.0 | Domain | t-SNARE coiled-coil homology | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376139 | 4 | 10 | 45_107 | 234.66666666666666 | 477.0 | Domain | t-SNARE coiled-coil homology | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376140 | 5 | 11 | 45_107 | 239.66666666666666 | 482.0 | Domain | t-SNARE coiled-coil homology | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376142 | 5 | 12 | 45_107 | 239.66666666666666 | 509.0 | Domain | t-SNARE coiled-coil homology | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376166 | 4 | 9 | 45_107 | 234.66666666666666 | 447.0 | Domain | t-SNARE coiled-coil homology | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376170 | 5 | 10 | 45_107 | 239.66666666666666 | 452.0 | Domain | t-SNARE coiled-coil homology | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000490841 | 3 | 7 | 45_107 | 175.66666666666666 | 330.0 | Domain | t-SNARE coiled-coil homology | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000346832 | 6 | 12 | 18_79 | 256.6666666666667 | 497.0 | Region | Required for binding to WASF1 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000359188 | 5 | 11 | 18_79 | 239.66666666666666 | 481.0 | Region | Required for binding to WASF1 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376138 | 5 | 10 | 18_79 | 239.66666666666666 | 453.0 | Region | Required for binding to WASF1 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376139 | 4 | 10 | 18_79 | 234.66666666666666 | 477.0 | Region | Required for binding to WASF1 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376140 | 5 | 11 | 18_79 | 239.66666666666666 | 482.0 | Region | Required for binding to WASF1 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376142 | 5 | 12 | 18_79 | 239.66666666666666 | 509.0 | Region | Required for binding to WASF1 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376166 | 4 | 9 | 18_79 | 234.66666666666666 | 447.0 | Region | Required for binding to WASF1 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000376170 | 5 | 10 | 18_79 | 239.66666666666666 | 452.0 | Region | Required for binding to WASF1 | |
| Tgene | ABI1 | chr10:133784141 | chr10:27054247 | ENST00000490841 | 3 | 7 | 18_79 | 175.66666666666666 | 330.0 | Region | Required for binding to WASF1 |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| ABI1 | ENAH, NCKAP1, EPS8L1, EPS8L2, EPS8L3, EPS8, ABL1, SOS1, NCK1, RYK, CACNA1A, CBL, NCK2, MBP, CDC123, CTTN, PIK3R1, PRKAA1, SRRM1, TCERG1, PRPF40A, APBB1, GAS7, WASF2, ZNF511, ODF3L2, UBXN11, VASP, DTNBP1, LHX4, PCMT1, BAIAP2, CYFIP1, CYFIP2, NCKAP1L, SF3A3, SSB, WASF1, WASL, MKI67, NHS, PPP2R1A, HOMER3, ABI2, RBM14, BRK1, NHSL1, KIAA1522, RAPH1, THOC6, Gtf2e2, Sass6, Nhsl1, TCF4, ZNF746, CDH1, IKBIP, AMZ1, WASF3, TIMM50, NHSL2, CGB2, COG6, CCDC22, C10orf88, CDH23, NXN, TRIM14, PCM1, ESR2, HRAS, EZR, LAMP1, ATG16L1, ACTC1, UL135, RPS6KA2, WWP2, SMARCD1, FBXL19, TTC23, FHL2, RCOR3, KIAA1217, FAM124B, ENKD1, TRIP10, VARS2, DTNB, EIF3H, HOMER1, HHEX, SORBS2, PRKAA2, RBM15, NFASC, HNRNPK, LMO1, C22orf15, CCDC57, MAB21L2, CCHCR1, PLEKHA4, IVNS1ABP, CORO1C, BCLAF1, PDCD4, PRPSAP1, AKAP12, SLC25A3, TUBB4B, TUBA1B, TRA2B, PRPS1, CMPK1, PRPS2, TUBB, SLC25A5, PRPSAP2, MYO1C, HSPA6, HSPA8, HSPB1, CAD, HSPA7, DPP7, HSD17B12, SLC25A11, ITGA3, ABI1, ESR1, KTN1, KIAA0408, MRFAP1, SRP68, SYNE2, MRFAP1L1, DST, SORBS1, TLN1, ACTN2, HULC, RIN3, OGT, C11orf52, KRAS, LAMTOR1, LCK, LYN, OCLN, RAB35, RAB9A, RHOB, STX4, STX7, ZFPL1, FXR1, SHANK3, TSC1, ARHGAP12, YWHAG, FGFR1OP2, CCR1, ACAA1, SPG11, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| BNIP3 | |
| ABI1 |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to BNIP3-ABI1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to BNIP3-ABI1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ABI1 | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
| Tgene | ABI1 | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
| Tgene | ABI1 | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
| Tgene | ABI1 | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
| Tgene | ABI1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Tgene | ABI1 | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
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