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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:YAP1-TMEM123

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: YAP1-TMEM123
FusionPDB ID: 99896
FusionGDB2.0 ID: 99896
HgeneTgene
Gene symbol

YAP1

TMEM123

Gene ID

10413

114908

Gene nameYes1 associated transcriptional regulatortransmembrane protein 123
SynonymsCOB1|YAP|YAP2|YAP65|YKIKCT3|PORIMIN|PORMIN
Cytomap

11q22.1

11q22.2

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional coactivator YAP165 kDa Yes-associated proteinYes associated protein 1protein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homologporiminKCT-3keratinocytes associated transmembrane protein 3pro-oncosis receptor inducing membrane injuryserine/threonine-rich receptor
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000282441, ENST00000345877, 
ENST00000524575, ENST00000526343, 
ENST00000531439, ENST00000537274, 
ENST00000528834, 
ENST00000525577, 
ENST00000532161, ENST00000361236, 
ENST00000398136, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 13 X 14=418611 X 8 X 5=440
# samples 2511
** MAII scorelog2(25/4186*10)=-4.06557231159362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: YAP1 [Title/Abstract] AND TMEM123 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TMEM123(102323254)-YAP1(102033186), # samples:1
YAP1(102033302)-TMEM123(102272937), # samples:1
Anticipated loss of major functional domain due to fusion event.YAP1-TMEM123 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
YAP1-TMEM123 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
YAP1-TMEM123 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
YAP1-TMEM123 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMEM123-YAP1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TMEM123-YAP1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYAP1

GO:0006974

cellular response to DNA damage stimulus

18280240

HgeneYAP1

GO:0008283

cell proliferation

17974916

HgeneYAP1

GO:0032570

response to progesterone

16772533

HgeneYAP1

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

16772533

HgeneYAP1

GO:0045893

positive regulation of transcription, DNA-templated

20368466

HgeneYAP1

GO:0045944

positive regulation of transcription by RNA polymerase II

25796446

HgeneYAP1

GO:0050767

regulation of neurogenesis

25433207

HgeneYAP1

GO:0050847

progesterone receptor signaling pathway

16772533

HgeneYAP1

GO:0060242

contact inhibition

17974916

HgeneYAP1

GO:0065003

protein-containing complex assembly

20368466

HgeneYAP1

GO:0071480

cellular response to gamma radiation

18280240

HgeneYAP1

GO:0072091

regulation of stem cell proliferation

25433207

TgeneTMEM123

GO:0070267

oncosis

9600958|11481458


check buttonFusion gene breakpoints across YAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM123 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-MY-A913-01AYAP1chr11

102033302

+TMEM123chr11

102272937

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000526343YAP1chr11102033302+ENST00000361236TMEM123chr11102272937-408110763881545385
ENST00000526343YAP1chr11102033302+ENST00000398136TMEM123chr11102272937-407710763881545385
ENST00000282441YAP1chr11102033302+ENST00000361236TMEM123chr11102272937-408110763881545385
ENST00000282441YAP1chr11102033302+ENST00000398136TMEM123chr11102272937-407710763881545385
ENST00000537274YAP1chr11102033302+ENST00000361236TMEM123chr11102272937-406310583701527385
ENST00000537274YAP1chr11102033302+ENST00000398136TMEM123chr11102272937-405910583701527385
ENST00000345877YAP1chr11102033302+ENST00000361236TMEM123chr11102272937-406310583701527385
ENST00000345877YAP1chr11102033302+ENST00000398136TMEM123chr11102272937-405910583701527385
ENST00000531439YAP1chr11102033302+ENST00000361236TMEM123chr11102272937-369368801157385
ENST00000531439YAP1chr11102033302+ENST00000398136TMEM123chr11102272937-368968801157385
ENST00000524575YAP1chr11102033302+ENST00000361236TMEM123chr11102272937-36045992621068268
ENST00000524575YAP1chr11102033302+ENST00000398136TMEM123chr11102272937-36005992621068268

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000526343ENST00000361236YAP1chr11102033302+TMEM123chr11102272937-0.0008754590.9991246
ENST00000526343ENST00000398136YAP1chr11102033302+TMEM123chr11102272937-0.000885520.99911445
ENST00000282441ENST00000361236YAP1chr11102033302+TMEM123chr11102272937-0.0008754590.9991246
ENST00000282441ENST00000398136YAP1chr11102033302+TMEM123chr11102272937-0.000885520.99911445
ENST00000537274ENST00000361236YAP1chr11102033302+TMEM123chr11102272937-0.0008643870.9991357
ENST00000537274ENST00000398136YAP1chr11102033302+TMEM123chr11102272937-0.0008705560.9991295
ENST00000345877ENST00000361236YAP1chr11102033302+TMEM123chr11102272937-0.0008643870.9991357
ENST00000345877ENST00000398136YAP1chr11102033302+TMEM123chr11102272937-0.0008705560.9991295
ENST00000531439ENST00000361236YAP1chr11102033302+TMEM123chr11102272937-0.0006785430.99932146
ENST00000531439ENST00000398136YAP1chr11102033302+TMEM123chr11102272937-0.0006854040.99931455
ENST00000524575ENST00000361236YAP1chr11102033302+TMEM123chr11102272937-0.0033388680.9966612
ENST00000524575ENST00000398136YAP1chr11102033302+TMEM123chr11102272937-0.0037145230.99628544

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99896_99896_1_YAP1-TMEM123_YAP1_chr11_102033302_ENST00000282441_TMEM123_chr11_102272937_ENST00000361236_length(amino acids)=385AA_BP=229
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTA
ASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVTHNSSVTSAASSVTITTTMHSEAKKGSKFDTGSFVGGIVLTLGVLSIL

--------------------------------------------------------------

>99896_99896_2_YAP1-TMEM123_YAP1_chr11_102033302_ENST00000282441_TMEM123_chr11_102272937_ENST00000398136_length(amino acids)=385AA_BP=229
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTA
ASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVTHNSSVTSAASSVTITTTMHSEAKKGSKFDTGSFVGGIVLTLGVLSIL

--------------------------------------------------------------

>99896_99896_3_YAP1-TMEM123_YAP1_chr11_102033302_ENST00000345877_TMEM123_chr11_102272937_ENST00000361236_length(amino acids)=385AA_BP=229
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTA
ASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVTHNSSVTSAASSVTITTTMHSEAKKGSKFDTGSFVGGIVLTLGVLSIL

--------------------------------------------------------------

>99896_99896_4_YAP1-TMEM123_YAP1_chr11_102033302_ENST00000345877_TMEM123_chr11_102272937_ENST00000398136_length(amino acids)=385AA_BP=229
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTA
ASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVTHNSSVTSAASSVTITTTMHSEAKKGSKFDTGSFVGGIVLTLGVLSIL

--------------------------------------------------------------

>99896_99896_5_YAP1-TMEM123_YAP1_chr11_102033302_ENST00000524575_TMEM123_chr11_102272937_ENST00000361236_length(amino acids)=268AA_BP=112
MTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAML
SQMNVTAPTSPPVQQNMMNSASETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTAASNTTTPGMVSTNMTSTTLKSTPKTTS

--------------------------------------------------------------

>99896_99896_6_YAP1-TMEM123_YAP1_chr11_102033302_ENST00000524575_TMEM123_chr11_102272937_ENST00000398136_length(amino acids)=268AA_BP=112
MTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAML
SQMNVTAPTSPPVQQNMMNSASETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTAASNTTTPGMVSTNMTSTTLKSTPKTTS

--------------------------------------------------------------

>99896_99896_7_YAP1-TMEM123_YAP1_chr11_102033302_ENST00000526343_TMEM123_chr11_102272937_ENST00000361236_length(amino acids)=385AA_BP=229
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTA
ASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVTHNSSVTSAASSVTITTTMHSEAKKGSKFDTGSFVGGIVLTLGVLSIL

--------------------------------------------------------------

>99896_99896_8_YAP1-TMEM123_YAP1_chr11_102033302_ENST00000526343_TMEM123_chr11_102272937_ENST00000398136_length(amino acids)=385AA_BP=229
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTA
ASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVTHNSSVTSAASSVTITTTMHSEAKKGSKFDTGSFVGGIVLTLGVLSIL

--------------------------------------------------------------

>99896_99896_9_YAP1-TMEM123_YAP1_chr11_102033302_ENST00000531439_TMEM123_chr11_102272937_ENST00000361236_length(amino acids)=385AA_BP=229
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTA
ASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVTHNSSVTSAASSVTITTTMHSEAKKGSKFDTGSFVGGIVLTLGVLSIL

--------------------------------------------------------------

>99896_99896_10_YAP1-TMEM123_YAP1_chr11_102033302_ENST00000531439_TMEM123_chr11_102272937_ENST00000398136_length(amino acids)=385AA_BP=229
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTA
ASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVTHNSSVTSAASSVTITTTMHSEAKKGSKFDTGSFVGGIVLTLGVLSIL

--------------------------------------------------------------

>99896_99896_11_YAP1-TMEM123_YAP1_chr11_102033302_ENST00000537274_TMEM123_chr11_102272937_ENST00000361236_length(amino acids)=385AA_BP=229
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTA
ASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVTHNSSVTSAASSVTITTTMHSEAKKGSKFDTGSFVGGIVLTLGVLSIL

--------------------------------------------------------------

>99896_99896_12_YAP1-TMEM123_YAP1_chr11_102033302_ENST00000537274_TMEM123_chr11_102272937_ENST00000398136_length(amino acids)=385AA_BP=229
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTA
ASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVTHNSSVTSAASSVTITTTMHSEAKKGSKFDTGSFVGGIVLTLGVLSIL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:102323254/chr11:102033186)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneYAP1chr11:102033302chr11:102272937ENST00000282441+3986_100229.33333333333334505.0Coiled coilOntology_term=ECO:0000269
HgeneYAP1chr11:102033302chr11:102272937ENST00000345877+3786_100229.33333333333334455.0Coiled coilOntology_term=ECO:0000269
HgeneYAP1chr11:102033302chr11:102272937ENST00000526343+3786_100229.33333333333334451.0Coiled coilOntology_term=ECO:0000269
HgeneYAP1chr11:102033302chr11:102272937ENST00000531439+3886_100229.33333333333334489.0Coiled coilOntology_term=ECO:0000269
HgeneYAP1chr11:102033302chr11:102272937ENST00000537274+3886_100229.33333333333334493.0Coiled coilOntology_term=ECO:0000269
HgeneYAP1chr11:102033302chr11:102272937ENST00000282441+393_49229.33333333333334505.0Compositional biasNote=Pro-rich
HgeneYAP1chr11:102033302chr11:102272937ENST00000345877+373_49229.33333333333334455.0Compositional biasNote=Pro-rich
HgeneYAP1chr11:102033302chr11:102272937ENST00000524575+393_4951.333333333333336327.0Compositional biasNote=Pro-rich
HgeneYAP1chr11:102033302chr11:102272937ENST00000526343+373_49229.33333333333334451.0Compositional biasNote=Pro-rich
HgeneYAP1chr11:102033302chr11:102272937ENST00000531439+383_49229.33333333333334489.0Compositional biasNote=Pro-rich
HgeneYAP1chr11:102033302chr11:102272937ENST00000537274+383_49229.33333333333334493.0Compositional biasNote=Pro-rich
HgeneYAP1chr11:102033302chr11:102272937ENST00000282441+39171_204229.33333333333334505.0DomainWW 1
HgeneYAP1chr11:102033302chr11:102272937ENST00000345877+37171_204229.33333333333334455.0DomainWW 1
HgeneYAP1chr11:102033302chr11:102272937ENST00000526343+37171_204229.33333333333334451.0DomainWW 1
HgeneYAP1chr11:102033302chr11:102272937ENST00000531439+38171_204229.33333333333334489.0DomainWW 1
HgeneYAP1chr11:102033302chr11:102272937ENST00000537274+38171_204229.33333333333334493.0DomainWW 1
TgeneTMEM123chr11:102033302chr11:102272937ENST000003612360452_15333.333333333333336190.0Compositional biasNote=Thr-rich
TgeneTMEM123chr11:102033302chr11:102272937ENST000003981361552_15352.333333333333336209.0Compositional biasNote=Thr-rich
TgeneTMEM123chr11:102033302chr11:102272937ENST0000036123604188_20833.333333333333336190.0Topological domainCytoplasmic
TgeneTMEM123chr11:102033302chr11:102272937ENST0000039813615188_20852.333333333333336209.0Topological domainCytoplasmic
TgeneTMEM123chr11:102033302chr11:102272937ENST0000036123604167_18733.333333333333336190.0TransmembraneHelical
TgeneTMEM123chr11:102033302chr11:102272937ENST0000039813615167_18752.333333333333336209.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneYAP1chr11:102033302chr11:102272937ENST00000282441+39298_359229.33333333333334505.0Coiled coilOntology_term=ECO:0000255
HgeneYAP1chr11:102033302chr11:102272937ENST00000345877+37298_359229.33333333333334455.0Coiled coilOntology_term=ECO:0000255
HgeneYAP1chr11:102033302chr11:102272937ENST00000524575+39298_35951.333333333333336327.0Coiled coilOntology_term=ECO:0000255
HgeneYAP1chr11:102033302chr11:102272937ENST00000524575+3986_10051.333333333333336327.0Coiled coilOntology_term=ECO:0000269
HgeneYAP1chr11:102033302chr11:102272937ENST00000526343+37298_359229.33333333333334451.0Coiled coilOntology_term=ECO:0000255
HgeneYAP1chr11:102033302chr11:102272937ENST00000531439+38298_359229.33333333333334489.0Coiled coilOntology_term=ECO:0000255
HgeneYAP1chr11:102033302chr11:102272937ENST00000537274+38298_359229.33333333333334493.0Coiled coilOntology_term=ECO:0000255
HgeneYAP1chr11:102033302chr11:102272937ENST00000282441+39230_263229.33333333333334505.0DomainWW 2
HgeneYAP1chr11:102033302chr11:102272937ENST00000345877+37230_263229.33333333333334455.0DomainWW 2
HgeneYAP1chr11:102033302chr11:102272937ENST00000524575+39171_20451.333333333333336327.0DomainWW 1
HgeneYAP1chr11:102033302chr11:102272937ENST00000524575+39230_26351.333333333333336327.0DomainWW 2
HgeneYAP1chr11:102033302chr11:102272937ENST00000526343+37230_263229.33333333333334451.0DomainWW 2
HgeneYAP1chr11:102033302chr11:102272937ENST00000531439+38230_263229.33333333333334489.0DomainWW 2
HgeneYAP1chr11:102033302chr11:102272937ENST00000537274+38230_263229.33333333333334493.0DomainWW 2
HgeneYAP1chr11:102033302chr11:102272937ENST00000282441+39291_504229.33333333333334505.0RegionNote=Transactivation domain
HgeneYAP1chr11:102033302chr11:102272937ENST00000345877+37291_504229.33333333333334455.0RegionNote=Transactivation domain
HgeneYAP1chr11:102033302chr11:102272937ENST00000524575+39291_50451.333333333333336327.0RegionNote=Transactivation domain
HgeneYAP1chr11:102033302chr11:102272937ENST00000526343+37291_504229.33333333333334451.0RegionNote=Transactivation domain
HgeneYAP1chr11:102033302chr11:102272937ENST00000531439+38291_504229.33333333333334489.0RegionNote=Transactivation domain
HgeneYAP1chr11:102033302chr11:102272937ENST00000537274+38291_504229.33333333333334493.0RegionNote=Transactivation domain
TgeneTMEM123chr11:102033302chr11:102272937ENST000003612360427_16633.333333333333336190.0Topological domainExtracellular
TgeneTMEM123chr11:102033302chr11:102272937ENST000003981361527_16652.333333333333336209.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
YAP1
TMEM123


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to YAP1-TMEM123


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to YAP1-TMEM123


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource