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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:SLC34A2_ROS1

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: SLC34A2_ROS1
	KinaseFusionDB ID: KFG5871
	FusionGDB2.0 ID: KFG5871
		Hgene	Tgene
	Gene symbol	SLC34A2	ROS1
	Gene ID	10568	6098
	Gene name	solute carrier family 34 member 2	ROS proto-oncogene 1, receptor tyrosine kinase
	Synonyms	NAPI-3B\|NAPI-IIb\|NPTIIb\|NaPi2b\|PULAM	MCF3\|ROS\|c-ros-1
	Cytomap	4p15.2	6q22.1
	Type of gene	protein-coding	protein-coding
	Description	sodium-dependent phosphate transport protein 2Bsodium/phosphate cotransporter 2Bsolute carrier family 34 (sodium phosphate), member 2solute carrier family 34 (type II sodium/phosphate cotransporter), member 2type II sodium-dependent phosphate transpor	proto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1
	Modification date	20240305	20240411
	UniProtAcc	O95436	P08922
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000382051, ENST00000503434, ENST00000504570, ENST00000510033,	ENST00000368507, ENST00000368508,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: SLC34A2 [Title/Abstract] AND ROS1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SLC34A2(25665952)-ROS1(117650611), # samples:4 SLC34A2(25665952)-ROS1(117645580), # samples:4

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SLC34A2	GO:0006817	phosphate ion transport	10329428\|10610722\|12488042
Hgene	SLC34A2	GO:0030643	intracellular phosphate ion homeostasis	10610722
Tgene	ROS1	GO:0001558	regulation of cell growth	16885344
Tgene	ROS1	GO:0006468	protein phosphorylation	16885344
Tgene	ROS1	GO:0032006	regulation of TOR signaling	16885344

Kinase Fusion gene breakpoints across SLC34A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across ROS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	EU236946	SLC34A2	chr4	25665952	ROS1	chr6	117609655
ChimerKB3	.	SLC34A2	chr4	25676251	ROS1	chr6	117645578
ChimerDB4	TCGA-05-4426-01A	SLC34A2	chr4	25678323	ROS1	chr6	117645577
ChimerDB4	TCGA-05-4426-01A	SLC34A2	chr4	25678324	ROS1	chr6	117645578
ChimerDB4	TCGA-62-A46Y-01A	SLC34A2	chr4	25678323	ROS1	chr6	117650608
ChimerDB4	TCGA-62-A46Y-01A	SLC34A2	chr4	25678324	ROS1	chr6	117650609
ChimerKB3	.	SLC34A2	chr4	25678323	ROS1	chr6	117650608
ChiTaRS5.0	AB795243	SLC34A2	chr4	25678324	ROS1	chr6	117650610
ChimerKB3	.	SLC34A2	chr4	25665952	ROS1	chr6	117650609
ChiTaRS5.0	EU236946	SLC34A2	chr4	25665952	ROS1	chr6	117650611
ChiTaRS5.0	EU236947	SLC34A2	chr4	25665952	ROS1	chr6	117645580

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000382051	ENST00000368508	SLC34A2	chr4	25678324	ROS1	chr6	117645578	5233	555
ENST00000382051	ENST00000368508	SLC34A2	chr4	25678324	ROS1	chr6	117650609	5542	555
ENST00000382051	ENST00000368508	SLC34A2	chr4	25678323	ROS1	chr6	117650608	5543	543
ENST00000382051	ENST00000368508	SLC34A2	chr4	25678323	ROS1	chr6	117645577	5234	516
ENST00000382051	ENST00000368508	SLC34A2	chr4	25678324	ROS1	chr6	117650610	5542	555
ENST00000504570	ENST00000368508	SLC34A2	chr4	25665952	ROS1	chr6	117650611	2436	738
ENST00000504570	ENST00000368508	SLC34A2	chr4	25665952	ROS1	chr6	117645580	2127	635
ENST00000504570	ENST00000368508	SLC34A2	chr4	25665952	ROS1	chr6	117650609	2436	738

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000382051_ENST00000368508_SLC34A2_chr4_25678324_ROS1_chr6_117645578_length(amino acids)=555
MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTL
QDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTS
IVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFK
NGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKE
NIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSV
FTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQVRSLPRTQRPNARPCRGRPRLSGMGGWSLSFACSPPSHF

--------------------------------------------------------------

>ENST00000382051_ENST00000368508_SLC34A2_chr4_25678324_ROS1_chr6_117650609_length(amino acids)=555
MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTL
QDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTS
IVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFK
NGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKE
NIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSV
FTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQVRSLPRTQRPNARPCRGRPRLSGMGGWSLSFACSPPSHF

--------------------------------------------------------------

>ENST00000382051_ENST00000368508_SLC34A2_chr4_25678323_ROS1_chr6_117650608_length(amino acids)=543
MTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKE
GVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKK
GSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMH
FIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPA
HSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLN
SDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGD

--------------------------------------------------------------

>ENST00000382051_ENST00000368508_SLC34A2_chr4_25678323_ROS1_chr6_117645577_length(amino acids)=516
MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTL
QDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTS
IVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFK
NGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKE
NIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSV

--------------------------------------------------------------

>ENST00000382051_ENST00000368508_SLC34A2_chr4_25678324_ROS1_chr6_117650610_length(amino acids)=555
MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTL
QDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTS
IVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFK
NGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKE
NIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSV
FTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQVRSLPRTQRPNARPCRGRPRLSGMGGWSLSFACSPPSHF

--------------------------------------------------------------

>ENST00000504570_ENST00000368508_SLC34A2_chr4_25665952_ROS1_chr6_117650611_length(amino acids)=738
MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKNNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQ
DSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIR
KSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLT
FVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILG
VGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDL
CVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGI
LIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVI
NESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKP

--------------------------------------------------------------

>ENST00000504570_ENST00000368508_SLC34A2_chr4_25665952_ROS1_chr6_117645580_length(amino acids)=635
MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKNNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQ
DSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSA
KEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTL
KKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLER
MHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPY
PAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVIC
LNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGY

--------------------------------------------------------------

>ENST00000504570_ENST00000368508_SLC34A2_chr4_25665952_ROS1_chr6_117650609_length(amino acids)=738
MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKNNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQ
DSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIR
KSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLT
FVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILG
VGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDL
CVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGI
LIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVI
NESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKP

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:25665952/chr6:117650611)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SLC34A2 O95436	ROS1 P08922
FUNCTION: Involved in actively transporting phosphate into cells via Na(+) cotransport. {ECO:0000269\|PubMed:10329428}.	FUNCTION: Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000250\|UniProtKB:Q78DX7, ECO:0000269\|PubMed:11094073, ECO:0000269\|PubMed:16885344}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner	Hgeneene	Hbp	Tgeneene	Tbp	ENST	BPexon	TotalExon	Protein feature loci	BPloci	TotalLen	Feature	Note
Tgene	SLC34A2	25665952	ROS1	117650609	ENST00000504570	30	43	1752_1854	1749	2348	Domain	Note=Fibronectin type-III 9;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Tgene	SLC34A2	25665952	ROS1	117650611	ENST00000504570	30	43	1752_1854	1749	2348	Domain	Note=Fibronectin type-III 9;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Tgene	SLC34A2	25678323	ROS1	117650608	ENST00000382051	30	43	1752_1854	1749	2348	Domain	Note=Fibronectin type-III 9;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Tgene	SLC34A2	25678324	ROS1	117650609	ENST00000382051	30	43	1752_1854	1749	2348	Domain	Note=Fibronectin type-III 9;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Tgene	SLC34A2	25678324	ROS1	117650610	ENST00000382051	30	43	1752_1854	1749	2348	Domain	Note=Fibronectin type-III 9;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
Tgene	SLC34A2	25665952	ROS1	117645580	ENST00000504570	32	43	1945_2222	1852	2348	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	SLC34A2	25665952	ROS1	117650609	ENST00000504570	30	43	1945_2222	1749	2348	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	SLC34A2	25665952	ROS1	117650611	ENST00000504570	30	43	1945_2222	1749	2348	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	SLC34A2	25678323	ROS1	117645577	ENST00000382051	32	43	1945_2222	1852	2348	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	SLC34A2	25678323	ROS1	117650608	ENST00000382051	30	43	1945_2222	1749	2348	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	SLC34A2	25678324	ROS1	117645578	ENST00000382051	32	43	1945_2222	1852	2348	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	SLC34A2	25678324	ROS1	117650609	ENST00000382051	30	43	1945_2222	1749	2348	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	SLC34A2	25678324	ROS1	117650610	ENST00000382051	30	43	1945_2222	1749	2348	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>453_SLC34A2_ROS1	ENST00000504570	ENST00000368508	SLC34A2	chr4	25665952	ROS1	chr6	117650609	MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKNNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQ DSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIR KSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLT FVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILG VGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDL CVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGI LIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVI NESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKP	738
3D view using mol* of 453_SLC34A2_ROS1

PDB file >>>TKFP_759_SLC34A2_ROS1	ENST00000382051	ENST00000368508	SLC34A2	chr4	25678324	ROS1	chr6	117645578	MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTL QDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTS IVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFK NGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKE NIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSV FTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQVRSLPRTQRPNARPCRGRPRLSGMGGWSLSFACSPPSHF	555_SLC34A2_ROS1
PDB file >>>TKFP_760_SLC34A2_ROS1	ENST00000382051	ENST00000368508	SLC34A2	chr4	25678324	ROS1	chr6	117650609	MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTL QDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTS IVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFK NGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKE NIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSV FTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQVRSLPRTQRPNARPCRGRPRLSGMGGWSLSFACSPPSHF	555_SLC34A2_ROS1
PDB file >>>TKFP_761_SLC34A2_ROS1	ENST00000382051	ENST00000368508	SLC34A2	chr4	25678323	ROS1	chr6	117650608	MTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKE GVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKK GSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMH FIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPA HSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLN SDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGD	543_SLC34A2_ROS1
3D view using mol* of TKFP_761_SLC34A2_ROS1

PDB file >>>TKFP_762_SLC34A2_ROS1	ENST00000382051	ENST00000368508	SLC34A2	chr4	25678323	ROS1	chr6	117645577	MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTL QDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTS IVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFK NGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKE NIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSV	516_SLC34A2_ROS1
3D view using mol* of TKFP_762_SLC34A2_ROS1

PDB file >>>TKFP_763_SLC34A2_ROS1	ENST00000382051	ENST00000368508	SLC34A2	chr4	25678324	ROS1	chr6	117650610	MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTL QDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTS IVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFK NGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKE NIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSV FTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQVRSLPRTQRPNARPCRGRPRLSGMGGWSLSFACSPPSHF	555_SLC34A2_ROS1
PDB file >>>TKFP_764_SLC34A2_ROS1	ENST00000504570	ENST00000368508	SLC34A2	chr4	25665952	ROS1	chr6	117650611	MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKNNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQ DSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIR KSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLT FVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILG VGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDL CVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGI LIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVI NESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKP	738_SLC34A2_ROS1
3D view using mol* of TKFP_764_SLC34A2_ROS1

PDB file >>>TKFP_765_SLC34A2_ROS1	ENST00000504570	ENST00000368508	SLC34A2	chr4	25665952	ROS1	chr6	117645580	MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKNNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQ DSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSA KEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTL KKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLER MHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPY PAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVIC LNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGY	635_SLC34A2_ROS1
3D view using mol* of TKFP_765_SLC34A2_ROS1

PDB file >>>TKFP_766_SLC34A2_ROS1	ENST00000504570	ENST00000368508	SLC34A2	chr4	25665952	ROS1	chr6	117650609	MAAASSPAPAEGALTMAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKNNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQ DSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIR KSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLT FVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILG VGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDL CVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGI LIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVI NESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKP	738_SLC34A2_ROS1

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

3D view using mol* of viewer/superimpose_isoforms/TKFP_759_SLC34A2_ROS1_vs_TKFP_761_SLC34A2_ROS1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_759_SLC34A2_ROS1_vs_TKFP_762_SLC34A2_ROS1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_759_SLC34A2_ROS1_vs_TKFP_764_SLC34A2_ROS1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_759_SLC34A2_ROS1_vs_TKFP_765_SLC34A2_ROS1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_761_SLC34A2_ROS1_vs_TKFP_762_SLC34A2_ROS1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_761_SLC34A2_ROS1_vs_TKFP_764_SLC34A2_ROS1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_761_SLC34A2_ROS1_vs_TKFP_765_SLC34A2_ROS1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_762_SLC34A2_ROS1_vs_TKFP_764_SLC34A2_ROS1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_762_SLC34A2_ROS1_vs_TKFP_765_SLC34A2_ROS1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_764_SLC34A2_ROS1_vs_TKFP_765_SLC34A2_ROS1_superimposed.pdb.html

Comparison of the Secondary Structures of Fusion Protein Isoforms

./secondary_str/TKFP_759_SLC34A2_ROS1_vs_TKFP_761_SLC34A2_ROS1.png

./secondary_str/TKFP_759_SLC34A2_ROS1_vs_TKFP_762_SLC34A2_ROS1.png

./secondary_str/TKFP_759_SLC34A2_ROS1_vs_TKFP_764_SLC34A2_ROS1.png

./secondary_str/TKFP_759_SLC34A2_ROS1_vs_TKFP_765_SLC34A2_ROS1.png

./secondary_str/TKFP_761_SLC34A2_ROS1_vs_TKFP_762_SLC34A2_ROS1.png

./secondary_str/TKFP_761_SLC34A2_ROS1_vs_TKFP_764_SLC34A2_ROS1.png

./secondary_str/TKFP_761_SLC34A2_ROS1_vs_TKFP_765_SLC34A2_ROS1.png

./secondary_str/TKFP_764_SLC34A2_ROS1_vs_TKFP_762_SLC34A2_ROS1.png

./secondary_str/TKFP_764_SLC34A2_ROS1_vs_TKFP_765_SLC34A2_ROS1.png

./secondary_str/TKFP_765_SLC34A2_ROS1_vs_TKFP_762_SLC34A2_ROS1.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

SLC34A2_ROS1 does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/453_SLC34A2_ROS1.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_761_SLC34A2_ROS1_updated_violin_plot.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_762_SLC34A2_ROS1_updated_violin_plot.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_764_SLC34A2_ROS1_updated_violin_plot.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

453_SLC34A2_ROS1.png

TKFP_761_SLC34A2_ROS1.png

TKFP_762_SLC34A2_ROS1.png

TKFP_764_SLC34A2_ROS1.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB	Site score	Size	Dscore	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
TKFP_761_SLC34A2_ROS1	1.093	116	1.122	318.304	0.453	0.801	1.105	1.884	0.915	2.058	1.109	Chain A: 145,147,148,149,155,157,172,174,176,206,2 22,223,224,225,226,227,228,229,232,233,236,279,282 ,286,298,301,302,305,306
TKFP_762_SLC34A2_ROS1	1.125	237	1.148	499.751	0.345	0.853	1.084	1.264	0.932	1.357	5.231	Chain A: 175,179,182,183,186,193,196,197,200,201,2 03,204,207,238,239,242,243,246,256,260,263,264,267 ,269,448,474,477,478,480,481,484,485,488,489,498,4 99,500,501,502,514,515,516
TKFP_764_SLC34A2_ROS1	1.128	129	1.173	344.715	0.439	0.816	1.1	2.095	0.789	2.654	0.88	Chain A: 340,342,343,344,350,352,367,369,371,388,3 92,401,417,418,419,420,421,422,423,424,427,428,431 ,474,477,481,493,494,496,497,500,501

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

453_SLC34A2_ROS1_ramachandran.png

TKFP_761_SLC34A2_ROS1_ramachandran.png

TKFP_762_SLC34A2_ROS1_ramachandran.png

TKFP_764_SLC34A2_ROS1_ramachandran.png

TKFP_765_SLC34A2_ROS1_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info

Drug

Docking score

Glide g score

Glide energy

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Kinase-Substrate Information of SLC34A2_ROS1

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase

Kinase UniProt Acc

Kinase species

Substrate

Substrate UniProt Acc

Substrate phosphorylated residues

Substrate phosphorylated sites (+/-7AA)

Domain

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase

GOID

GO term

P.adjust

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Related Drugs to SLC34A2_ROS1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning SLC34A2-ROS1 and kinase inhibitors the PubMed Abstract (04-01-2024)

all structure sitemap plddt SLC34A2-ROS1

Fusion gene - drug pair 1	Fusion gene - drug pair 2	PMID	Publication date	DOI	Study title
CD74-ROS1 AND Crizotinib	SLC34A2-ROS1 AND Crizotinib	30053332	2018-09-11	10.1111/cas.13752	Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions.
CD74-ROS1 AND Crizotinib	SLC34A2-ROS1 AND Crizotinib	25688157	2015-05-14	10.1158/1078-0432.ccr-14-1350	Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer.
EML4-ALK AND Imatinib	SLC34A2-ROS1 AND Crizotinib	22617245	2012-7	10.1097/jto.0b013e3182570919	Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer.
SLC34A2-ROS1 AND Crizotinib		38070598	2024-4	10.1016/j.jtho.2023.12.009	CD74/SLC34A2-ROS1 Fusion Variants Involving the Transmembrane Region Predict Poor Response to Crizotinib in NSCLC Independent of TP53 Mutations.
SLC34A2-ROS1 AND Crizotinib		28860822	2017-8	10.2147/ott.s136297	Response to crizotinib in a lung adenocarcinoma patient harboring a novel SLC34A2-ROS1 fusion variant.

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Related Diseases to SLC34A2_ROS1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
SLC34A2	ROS1	Lung Adenocarcinoma	MyCancerGenome
SLC34A2	ROS1	Dedifferentiated Liposarcoma	MyCancerGenome
SLC34A2	ROS1	Breast Invasive Ductal Carcinoma	MyCancerGenome
SLC34A2	ROS1	Anaplastic Ganglioglioma	MyCancerGenome
SLC34A2	ROS1	Cancer Of Unknown Primary	MyCancerGenome

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	SLC34A2	C0155912	Pulmonary Alveolar Microlithiasis	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	SLC34A2	C0007131	Non-Small Cell Lung Carcinoma	2	CTD_human
Tgene	ROS1	C0007131	Non-Small Cell Lung Carcinoma	4	CTD_human

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene	Kinase Inhibitor	NCT ID	Study Status	Phases	Disease	# Enrolment	Date
SLC34A2-ROS1	Crizotinib	NCT03399487	Unknown status	Phase 2	Non-small Cell Lung Cancer Harboring ROS1 Rearrangement	46	October 2020
SLC34A2-ROS1	Crizotinib	NCT01964157	Unknown status	Phase 2	Non-small Cell Lung Cancer (NSCLC)	32	December 2019