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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: SYNCRIP (NCBI Gene ID:10492)


Gene Summary

check button Gene Summary
Gene InformationGene Name: SYNCRIP
Gene ID: 10492
Gene Symbol

SYNCRIP

Gene ID

10492

Gene Namesynaptotagmin binding cytoplasmic RNA interacting protein
SynonymsGRY-RBP|GRYRBP|HNRNPQ|HNRPQ1|NSAP1|PP68|hnRNP-Q
Cytomap

6q14.3

Type of Geneprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein QNS1-associated protein 1glycine- and tyrosine-rich RNA-binding protein
Modification date20200327
UniProtAcc

O60506


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0017148Negative regulation of translation
GO:0006417Regulation of translation
GO:0045727Positive regulation of translation
GO:0002181Cytoplasmic translation
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSYNCRIP

GO:0017148

negative regulation of translation

23071094

HgeneSYNCRIP

GO:0071346

cellular response to interferon-gamma

15479637



check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
SYNCRIP(733 - 1119.25]


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Translation Studies in PubMed

check button We searched PubMed using 'SYNCRIP[title] AND translation [title] AND human.'
GeneTitlePMID
SYNCRIPSYNCRIP, a component of dendritically localized mRNPs, binds to the translation regulator BC200 RNA18045242


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST000003696228632898586329135In-frame
ENST000003696228633369486333830Frame-shift
ENST000003696228634668486346861In-frame
ENST000003696228634696086347074In-frame
ENST0000036962286351009863511693UTR-3CDS

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)
ENST000003696228632898586329135304015101659623336386
ENST00000369622863466848634686130409911167623163222
ENST0000036962286346960863470743040877990623125163

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
STADSYNCRIP-3.246950404899340.00222697434946895
THCASYNCRIP-3.159464298099882.46790521879123e-10


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue
BRCASYNCRIPhsa-miR-196b-5p880.3075462512171370.00601593831679952


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
all structure
Cancer typeGeneCoefficientPvalue
KIRCSYNCRIP0.0361764450.017847429
LIHCSYNCRIP0.078958020.037502156
MESOSYNCRIP-0.0745944020.047141413

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with SYNCRIP (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
all structure
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue
CHOLIUPHARSYNCRIPSENP60.8011246913.87E-11
KICHCell metabolism geneSYNCRIPNUP1530.829601363.02E-24
KICHCGCSYNCRIPCDK120.8117300971.69E-22
KICHIUPHARSYNCRIPCDK120.8117300971.69E-22
KICHKinaseSYNCRIPCDK120.8117300971.69E-22
PRADCGCSYNCRIPGOPC0.8193565011.60E-134
PRADCGCSYNCRIPBCLAF10.8361324974.90E-145
PRADEpifactorSYNCRIPHDAC20.8018848661.13E-124
PRADEpifactorSYNCRIPMAP3K70.8378668623.43E-146
PRADIUPHARSYNCRIPHDAC20.8018848661.13E-124
PRADIUPHARSYNCRIPTMEM30A0.812325191.96E-130
PRADIUPHARSYNCRIPSENP60.8126929031.21E-130
PRADIUPHARSYNCRIPMAP3K70.8378668623.43E-146
PRADKinaseSYNCRIPMAP3K70.8378668623.43E-146
PRADTFSYNCRIPCDC5L0.8058577657.98E-127
THYMCell metabolism geneSYNCRIPCCNC0.8046649686.09E-29
THYMCell metabolism geneSYNCRIPAGPS0.8309298792.42E-32
THYMCell metabolism geneSYNCRIPNFYA0.8716155985.80E-39
THYMCGCSYNCRIPGOPC0.8006359291.82E-28
THYMCGCSYNCRIPCCNC0.8046649686.09E-29
THYMCGCSYNCRIPCREB10.8085502742.07E-29
THYMCGCSYNCRIPRAD210.808911231.87E-29
THYMCGCSYNCRIPSUZ120.814535943.72E-30
THYMCGCSYNCRIPFANCF0.8183828881.19E-30
THYMCGCSYNCRIPFGFR1OP0.8266065219.62E-32
THYMCGCSYNCRIPMSH20.839099271.61E-33
THYMCGCSYNCRIPDEK0.8449711192.08E-34
THYMCGCSYNCRIPCBL0.8506518442.64E-35
THYMEpifactorSYNCRIPATAD2B0.8037919127.74E-29
THYMEpifactorSYNCRIPSENP10.8088703361.89E-29
THYMEpifactorSYNCRIPRCOR10.8130022795.80E-30
THYMEpifactorSYNCRIPSUZ120.814535943.72E-30
THYMEpifactorSYNCRIPZNF7110.8200230567.30E-31
THYMEpifactorSYNCRIPING30.8309703892.39E-32
THYMEpifactorSYNCRIPDR10.8387712691.80E-33
THYMEpifactorSYNCRIPDEK0.8449711192.08E-34
THYMEpifactorSYNCRIPMBTD10.8485253765.77E-35
THYMIUPHARSYNCRIPATAD2B0.8037919127.74E-29
THYMIUPHARSYNCRIPCRY10.8043134696.71E-29
THYMIUPHARSYNCRIPSENP10.8088703361.89E-29
THYMIUPHARSYNCRIPSRPK20.816832341.89E-30
THYMIUPHARSYNCRIPOXSR10.8176631111.48E-30
THYMIUPHARSYNCRIPHIPK10.8274602187.35E-32
THYMKinaseSYNCRIPSRPK20.816832341.89E-30
THYMKinaseSYNCRIPOXSR10.8176631111.48E-30
THYMKinaseSYNCRIPHIPK10.8274602187.35E-32
THYMTFSYNCRIPZNF1430.8077446362.59E-29
THYMTFSYNCRIPCREB10.8085502742.07E-29
THYMTFSYNCRIPE2F70.8107321681.11E-29
THYMTFSYNCRIPZNF280D0.8150816933.17E-30
THYMTFSYNCRIPZKSCAN40.8196193568.25E-31
THYMTFSYNCRIPZNF7110.8200230567.30E-31
THYMTFSYNCRIPZBTB20.8267841169.10E-32
THYMTFSYNCRIPCGGBP10.8274458017.38E-32
THYMTFSYNCRIPZNF1840.8372931072.97E-33
THYMTFSYNCRIPDR10.8387712691.80E-33
THYMTFSYNCRIPZNF5190.8540270477.45E-36
THYMTFSYNCRIPNFYA0.8716155985.80E-39
THYMTFSYNCRIPCDC5L0.8742884151.78E-39
THYMTFSYNCRIPHSF20.8763197357.15E-40
THYMTSGSYNCRIPCCNC0.8046649686.09E-29
THYMTSGSYNCRIPSUZ120.814535943.72E-30
THYMTSGSYNCRIPING30.8309703892.39E-32
THYMTSGSYNCRIPMSH20.839099271.61E-33
THYMTSGSYNCRIPCBL0.8506518442.64E-35
THYMTSGSYNCRIPLIN90.8607369785.45E-37
UCSCell metabolism geneSYNCRIPCCNC0.8046649686.09E-29
UCSCell metabolism geneSYNCRIPAGPS0.8309298792.42E-32
UCSCell metabolism geneSYNCRIPNFYA0.8716155985.80E-39
UCSCGCSYNCRIPGOPC0.8006359291.82E-28
UCSCGCSYNCRIPCCNC0.8046649686.09E-29
UCSCGCSYNCRIPCREB10.8085502742.07E-29
UCSCGCSYNCRIPRAD210.808911231.87E-29
UCSCGCSYNCRIPSUZ120.814535943.72E-30
UCSCGCSYNCRIPFANCF0.8183828881.19E-30
UCSCGCSYNCRIPFGFR1OP0.8266065219.62E-32
UCSCGCSYNCRIPMSH20.839099271.61E-33
UCSCGCSYNCRIPDEK0.8449711192.08E-34
UCSCGCSYNCRIPCBL0.8506518442.64E-35
UCSEpifactorSYNCRIPATAD2B0.8037919127.74E-29
UCSEpifactorSYNCRIPSENP10.8088703361.89E-29
UCSEpifactorSYNCRIPRCOR10.8130022795.80E-30
UCSEpifactorSYNCRIPSUZ120.814535943.72E-30
UCSEpifactorSYNCRIPZNF7110.8200230567.30E-31
UCSEpifactorSYNCRIPING30.8309703892.39E-32
UCSEpifactorSYNCRIPDR10.8387712691.80E-33
UCSEpifactorSYNCRIPDEK0.8449711192.08E-34
UCSEpifactorSYNCRIPMBTD10.8485253765.77E-35
UCSIUPHARSYNCRIPATAD2B0.8037919127.74E-29
UCSIUPHARSYNCRIPCRY10.8043134696.71E-29
UCSIUPHARSYNCRIPSENP10.8088703361.89E-29
UCSIUPHARSYNCRIPSRPK20.816832341.89E-30
UCSIUPHARSYNCRIPOXSR10.8176631111.48E-30
UCSIUPHARSYNCRIPHIPK10.8274602187.35E-32
UCSKinaseSYNCRIPSRPK20.816832341.89E-30
UCSKinaseSYNCRIPOXSR10.8176631111.48E-30
UCSKinaseSYNCRIPHIPK10.8274602187.35E-32
UCSTFSYNCRIPZNF1430.8077446362.59E-29
UCSTFSYNCRIPCREB10.8085502742.07E-29
UCSTFSYNCRIPE2F70.8107321681.11E-29
UCSTFSYNCRIPZNF280D0.8150816933.17E-30
UCSTFSYNCRIPZKSCAN40.8196193568.25E-31
UCSTFSYNCRIPZNF7110.8200230567.30E-31
UCSTFSYNCRIPZBTB20.8267841169.10E-32
UCSTFSYNCRIPCGGBP10.8274458017.38E-32
UCSTFSYNCRIPZNF1840.8372931072.97E-33
UCSTFSYNCRIPDR10.8387712691.80E-33
UCSTFSYNCRIPZNF5190.8540270477.45E-36
UCSTFSYNCRIPNFYA0.8716155985.80E-39
UCSTFSYNCRIPCDC5L0.8742884151.78E-39
UCSTFSYNCRIPHSF20.8763197357.15E-40
UCSTSGSYNCRIPCCNC0.8046649686.09E-29
UCSTSGSYNCRIPSUZ120.814535943.72E-30
UCSTSGSYNCRIPING30.8309703892.39E-32
UCSTSGSYNCRIPMSH20.839099271.61E-33
UCSTSGSYNCRIPCBL0.8506518442.64E-35
UCSTSGSYNCRIPLIN90.8607369785.45E-37
UVMCell metabolism geneSYNCRIPNUP430.8223999658.52E-21
UVMCell metabolism geneSYNCRIPAGPAT50.8306814221.56E-21
UVMCell metabolism geneSYNCRIPMED230.8434600939.47E-23
UVMCell metabolism geneSYNCRIPPGM30.8584450732.52E-24
UVMCGCSYNCRIPFGFR1OP0.8201495991.33E-20
UVMCGCSYNCRIPGOPC0.822557968.25E-21
UVMCGCSYNCRIPBCLAF10.8230124727.54E-21
UVMEpifactorSYNCRIPHDAC20.8580306952.80E-24
UVMIUPHARSYNCRIPHDAC20.8580306952.80E-24
UVMTFSYNCRIPZBTB20.81147237.00E-20
UVMTFSYNCRIPZUFSP0.8554824495.33E-24


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
check button
* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
KICHSYNCRIPHNRNPR1.520761514083350.000102996826171875
COADSYNCRIPHNRNPU-3.254143675860130.000109195709228516
STADSYNCRIPHNRNPR-4.62256613084160.000364991836249828
KICHSYNCRIPHNRNPU1.452708658911020.000376403331756592
LUADSYNCRIPHNRNPA1-1.176803998249060.000379797766386831
PRADSYNCRIPHNRNPU-3.592550102004530.00074054058184854
STADSYNCRIPEPRS-1.481715813246470.000789262883452143
THCASYNCRIPRPL13A1.000555295574890.00121938003080576
ESCASYNCRIPHNRNPR-4.722717990819770.0029296875
THCASYNCRIPHNRNPK-8.734225425633890.00797530353045887
CHOLSYNCRIPHNRNPR-1.465669487673760.01171875
LUSCSYNCRIPCSDE1-1.332001176612280.025379830388344
CHOLSYNCRIPGAPDH-3.073547852614750.02734375
UCECSYNCRIPHNRNPK1.645327445048640.03125
KIRCSYNCRIPRPL13A-2.225700454772561.02382991067149e-08
BRCASYNCRIPGAPDH-1.376429025678851.15182974050406e-18
HNSCSYNCRIPCSDE1-1.925747629562051.42088565553422e-05
THCASYNCRIPCSDE1-1.005819457904211.55171507174296e-05
BRCASYNCRIPCSDE1-1.235750015657021.5698167165288e-21
STADSYNCRIPHNRNPU-1.265669523208152.26888805627823e-05
LIHCSYNCRIPEPRS-7.107310178115052.28054594243154e-08
LIHCSYNCRIPHNRNPU-1.060986582157732.35319665208461e-06
BRCASYNCRIPYBX11.104672419664514.8741280959683e-05
KIRCSYNCRIPHNRNPR1.794181915577455.98807464268008e-07
KIRCSYNCRIPHNRNPA1-6.806888427010166.00852501097204e-09
LUADSYNCRIPCSDE1-1.925739540164576.46801743847803e-05
BRCASYNCRIPIGF2BP1-1.1192646365866.55843695441879e-13
LUADSYNCRIPGAPDH-2.396252428629647.0750762948169e-11
KICHSYNCRIPYBX11.869232591604728.16583633422851e-06
LUSCSYNCRIPHNRNPA1-2.5974238417649.46872220956927e-06
PRADSYNCRIPEPRS-1.763391274572659.52775218277559e-05


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with SYNCRIP
PTPN11, PUF60, PRKRA, STK24, CNBP, PRMT1, APOBEC1, A1CF, SYT2, SYT7, SYT8, SYT9, SYT1, SYT3, SYT4, GRB2, PLCG1, INSR, MEPCE, CDK9, HNRNPA1, HNRNPH1, KHDRBS2, DOT1L, H2AFX, UBC, Ybx1, AI837181, EBNA-LP, RAD21, SF3A2, SIRT7, PAIP1, CUL3, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, HNRNPD, APP, PABPC1, HNRNPR, HNRNPA3, SRSF1, HNRNPK, HNRNPM, SRSF3, TARDBP, YBX1, ILF3, ILF2, DHX15, SNRPA1, DDX5, RALY, SRRM2, U2AF1, PPP1CA, U2AF2, SNRNP70, DDX42, DDX3X, EIF4H, IGF2BP1, PHB, PTCD3, RPL10, RBMS2, STT3B, WBSCR16, TIMM50, HNRNPA0, NDUFV2, LSM14A, IKBIP, ICT1, MYL12A, STOML2, PLP2, LETM1, RPUSD4, RPN1, SNAP23, DLAT, GAA, TMEM177, LGALS3BP, TXN, MRPS28, RPS20, ESR1, HABP4, SMURF1, FN1, VCAM1, HNRNPU, TP63, IL7R, UBL4A, ITGA4, PRMT8, CD81, IGSF8, ICAM1, HMGA1, HMGA2, CSF2, FBXO6, PARK2, IQGAP1, C14orf166, NELFB, FKBP3, GNB2L1, IARS, RPSA, MAP1S, PSMD7, RPL23A, RPL24, RPS21, RPS27L, rev, RPA3, RPA2, RPA1, STAU1, SPRTN, FUS, NUPR1, CUL7, OBSL1, CCDC8, EED, RNF2, SIRT6, FBXW11, MAEL, DDX17, MORF4L1, MORF4L2, NHP2L1, CAPN1, HNRNPL, KHDRBS1, KHDRBS3, LSM4, LUC7L, LUC7L2, METTL13, NCBP2, SF3B3, THUMPD1, UBE2S, UPF1, XRN1, ZNF598, NTRK1, SCARNA22, APBB2, BAD, BLMH, SLC25A20, CRY1, DKC1, DYNC1H1, ECHS1, PHC2, EIF2B1, CTTN, MTOR, GOLGA3, HBA1, HEXA, HNRNPAB, MAPT, MAP3K4, MKI67, MYH1, NDUFB5, NHS, NOP2, PDCL, PI4KA, PLCB3, PSMD2, PTMA, RECQL, RET, SCO1, SDC2, SS18, TARBP1, ZEB1, GCFC2, TLN1, TNFRSF1A, USP1, ZBTB14, RBM10, USP13, MTA1, PTTG1, COX5A, MRPL33, GTF2IRD1, ARHGAP32, C2CD5, HMGXB4, CEBPZ, SORBS3, TCIRG1, ABCA7, TUBB3, CDK2, HNRNPH2, PCDH7, SORT1, TSNAX, KIF21B, MRPL50, TXNL4A, EBNA1BP2, TRIOBP, HNRNPUL1, FNDC3A, SETD1B, FAM120A, MED13L, DICER1, MACF1, INTS7, TBC1D10B, WDR91, ANKRD11, RACGAP1, PNPLA8, RRP15, TRMT112, PPIL1, PPIL3, APTX, UHRF1BP1, UACA, CEP55, NAT10, UFSP2, DNAJA4, NOP10, PLXNA3, PRPF40A, BIN3, DDX24, ZNF286A, UVSSA, ICE2, IPO4, ELMO3, SBF2, TLN2, KLF16, USP32, FBXO18, SLC25A25, PTGR2, CENPV, LEMD2, NSMCE2, Junb, Nedd1, Nfyc, MCM2, MCM5, SNW1, WWP2, ZNF746, RBMXL1, ANGEL2, RPS27A, APOBEC3D, SFPQ, YTHDF1, HDLBP, RPL26L1, ZNF169, ELAVL4, DUSP11, ZC3H8, KNOP1, DDX54, CCDC137, DDX21, ZRANB2, GAR1, UTP3, QKI, CCDC59, DDX27, ELAVL2, NKAP, YPEL5, CYLD, TRIM25, G3BP1, UBE2A, BRCA1, HBP1, WDR77, CTNNB1, PPIE, YAP1, BMP4, HDAC4, KRAS, PCBP1, TRIP4, UBE2L6, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, CHD3, CHD4, TNF, RIOK1, HEXIM1, LARP7, RUNX1, UBE3A, SNAI1, HRAS, AGR2, RECQL4, GPC1, REST, ZFP36L2, MYC, WDR76, HIST1H4A, HIST1H2BB, HIST1H2AB, METTL3, METTL14, KIAA1429, RC3H1, RC3H2, FAF1, CHEK2, DISC1, USP14, NR2C2, HDAC2, MECOM, NHLRC2, VRK1, OASL, MAB21L2, DUSP14, TAF15, MATR3, ITFG1, BIRC3, NFX1, BRD7, TP53, GRIA4, GRIA1, CMTR1, MYPOP, ARIH2, PLEKHA4, KCTD10, PINK1, TFCP2, FANCD2, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, ZC3H18, DUSP1, TOR1AIP1, PKD1L2, CELF1, CPEB4, DAZL, ELAVL1, FUBP3, GRSF1, IGF2BP2, LARP4B, MKRN2, MOV10, PAIP2, PUM1, RBMS1, AIFM1, ALG13, ATXN2, BYSL, CSDE1, DDX20, EIF4ENIF1, FAM120C, GEMIN4, IGF2BP3, IPO8, OTUD4, PRRC2C, R3HDM1, SMG7, SMN1, SND1, TDRD3, TOP3B, YTHDF2, ZCCHC6, XRN2, ZC3HAV1, ANKRD28, DAP3, G3BP2, LARP4, LTV1, MRPS26, PABPC4, CAPRIN1, FMR1, PRRC2A, PRRC2B, SECISBP2, STAU2, YTHDF3, DHX57, LARP1B, MRPS34, ZC3H7A, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, TRIM55, TRIM63, ACAD9, C6orf203, MDH2, METTL15, METTL17, MRRF, MTERF3, MTIF3, TUFM, SUMO2, NDN, BRD4, RBM45, CIC, Apc2, RBM39, FBP1, MKRN1, LGALS9, IFI16, N, FAM20C, DNAJC8, EWSR1, OGT, CD274, UFL1, DDRGK1, NR4A1, KIAA1524, FBL, SERBP1, TRIM37, UBQLN1, FZR1, WDR5, NUDCD2, ZBTB2, PRR3, RBM28, RPS3, DHX36, MRPL30, PURG, HNRNPUL2, YTHDC2, HNRNPC, MRPS24, MALSU1, YBX2, SNRPC, GAPDHS, GNA13, BTF3, FBXW7, ORF8, ORF10, ORF6, ORF7b, S, AGO1, SQSTM1, PER2, CPEB1, RB1CC1,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo
SYNCRIPchr686324772TGAAIndelassociationAutism_spectrum_disorderSO:0001583|missense_variantSO:0001583|missense_variant
SYNCRIPchr686324785CTsingle_nucleotide_variantUncertain_significanceIntellectual_disabilitySO:0001583|missense_variantSO:0001583|missense_variant
SYNCRIPchr686328600CACDeletionUncertain_significancenot_providedSO:0001589|frameshift_variantSO:0001589|frameshift_variant
SYNCRIPchr686332348CCTCMicrosatelliteLikely_pathogenicnot_providedSO:0001589|frameshift_variantSO:0001589|frameshift_variant
SYNCRIPchr686332353GGTDuplicationUncertain_significancenot_providedSO:0001589|frameshift_variantSO:0001589|frameshift_variant
SYNCRIPchr686346722AGsingle_nucleotide_variantassociationAutism_spectrum_disorderSO:0001583|missense_variantSO:0001583|missense_variant
SYNCRIPchr686346961CGsingle_nucleotide_variantUncertain_significancenot_providedSO:0001583|missense_variant,SO:0001627|intron_variantSO:0001583|missense_variant,SO:0001627|intron_variant
SYNCRIPchr686351111TCsingle_nucleotide_variantUncertain_significanceSee_casesSO:0001583|missense_variant,SO:0001627|intron_variantSO:0001583|missense_variant,SO:0001627|intron_variant


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
SYNCRIPSKCMchr68633381286333812GAMissense_Mutationp.R229C5
SYNCRIPUCECchr68633238186332381TCMissense_Mutationp.Y276C3
SYNCRIPLUSCchr68632491386324913CTMissense_Mutationp.R478H3
SYNCRIPUCECchr68635017186350171TCMissense_Mutationp.H87R3
SYNCRIPGBMchr68632902386329023GTMissense_Mutation3
SYNCRIPBRCAchr68635019986350199GANonsense_Mutationp.Q78*3
SYNCRIPBRCAchr68635107486351074CTSilentp.Q283
SYNCRIPKIRPchr68633235386332354-TFrame_Shift_Insp.N285fs3
SYNCRIPHNSCchr68632853886328538TCSilentp.Q426Q3
SYNCRIPSARCchr68632902386329023GAMissense_Mutationp.A374V3
SYNCRIPESCAchr68632492986324929CGMissense_Mutationp.D473H3
SYNCRIPPAADchr68634673486346734GAMissense_Mutationp.A206V3
SYNCRIPSKCMchr68632479586324795GASilentp.P419P2
SYNCRIPTGCTchr68634682686346826CTSilent2
SYNCRIPESCAchr68632492986324929CGMissense_Mutation2
SYNCRIPHNSCchr68634676586346765CGMissense_Mutationp.D196H2
SYNCRIPSTADchr68634999486349994TCMissense_Mutationp.K107R2
SYNCRIPCHOLchr68635113486351134TCSilent2
SYNCRIPTGCTchr68634682686346826CTSilentp.E175E2
SYNCRIPBRCAchr68633225486332254TCSilentp.G3182
SYNCRIPPRADchr68633375686333756CASilentp.V247V2
SYNCRIPCHOLchr68635113486351134TCSilentp.G8G2
SYNCRIPSTADchr68633235486332354T-Frame_Shift_Del2
SYNCRIPSTADchr68634676286346762GAMissense_Mutationp.P197S2
SYNCRIPUCECchr68632496786324967TCMissense_Mutationp.Y460C2
SYNCRIPSTADchr68632491386324913CTMissense_Mutation2
SYNCRIPSTADchr68633229886332298GAMissense_Mutationp.R304C2
SYNCRIPUCECchr68632899386328993GTMissense_Mutationp.A384D2
SYNCRIPLUADchr68632501586325015CGMissense_Mutationp.R444T2
SYNCRIPCESCchr68632478286324782CTMissense_Mutation2
SYNCRIPUCECchr68632904786329047CTMissense_Mutationp.R366Q2
SYNCRIPSTADchr68632902886329028ATMissense_Mutationp.D372E2
SYNCRIPCESCchr68632490086324900TCSilent2
SYNCRIPUCECchr68632908586329085ACMissense_Mutationp.I353M2
SYNCRIPCESCchr68632474886324748CGMissense_Mutation2
SYNCRIPSARCchr68633372386333723CGMissense_Mutation2
SYNCRIPUCECchr68633239186332391CTMissense_Mutationp.V273I2
SYNCRIPLIHCchr68632856586328565T-Frame_Shift_Delp.K417fs2
SYNCRIPHNSCchr68632862786328627CTMissense_Mutationp.E397K2
SYNCRIPUCECchr68635023286350232CANonsense_Mutationp.E67*2
SYNCRIPLIHCchr68635023786350237A-Frame_Shift_Delp.L65fs2
SYNCRIPLUADchr68632900386329003GCMissense_Mutationp.R381G2
SYNCRIPSTADchr68632461386324613CTMissense_Mutationp.R578H2
SYNCRIPCESCchr68634999886349998CTMissense_Mutation2
SYNCRIPLIHCchr68633235486332354T-Frame_Shift_Delp.N285fs2
SYNCRIPLUADchr68635113086351130CTMissense_Mutationp.G10S2
SYNCRIPHNSCchr68632454786324547TAMissense_Mutationp.H600L2
SYNCRIPSTADchr68632468886324688GAMissense_Mutationp.A553V2
SYNCRIPSARCchr68633372386333723CGMissense_Mutationp.Q258H2
SYNCRIPESCAchr68633236386332363TAMissense_Mutationp.K282M2
SYNCRIPLIHCchr68632854286328542T-Frame_Shift_Delp.N425fs2
SYNCRIPLUADchr68634682886346828CTMissense_Mutationp.E175K2
SYNCRIPSTADchr68632483286324832C-Frame_Shift_Delp.G505fs2
SYNCRIPTHYMchr68632470386324703CAMissense_Mutationp.R548L1
SYNCRIPCESCchr68634999886349998CTMissense_Mutationp.E106K1
SYNCRIPLGGchr68632482586324825AGSilent1
SYNCRIPLUADchr68635003986350040-TTFrame_Shift_Insp.C92fs1
SYNCRIPSKCMchr68632455186324553CAC-In_Frame_Delp.GD598del1
SYNCRIPLIHCchr68633378086333780TCSilent1
SYNCRIPBLCAchr68634996086349963TCCT-Frame_Shift_Delp.K117fs1
SYNCRIPPAADchr68632472886324728CAMissense_Mutation1
SYNCRIPLIHCchr68633234686332346AGMissense_Mutation1
SYNCRIPSKCMchr68632488486324884A-Frame_Shift_Delp.Y453fs1
SYNCRIPSKCMchr68632488486324884A-Frame_Shift_Delp.Y488fs1
SYNCRIPESCAchr68632491186324911CAMissense_Mutationp.G479C1
SYNCRIPLUADchr68632491686324916TAMissense_Mutationp.Y477F1
SYNCRIPHNSCchr68632479586324795GASilentp.P517P1
SYNCRIPSTADchr68633234986332350CT-Frame_Shift_Delp.287_287del1
SYNCRIPLIHCchr68635113886351138TCMissense_Mutation1
SYNCRIPSKCMchr68632459986324599GANonsense_Mutationp.Q583X1
SYNCRIPTHCAchr68632458486324584GTMissense_Mutation1
SYNCRIPLUSCchr68633236386332363TGMissense_Mutationp.K282T1
SYNCRIPLUADchr68635028286350282CASplice_Sitep.G50_splice1
SYNCRIPKIRCchr68632482886324828AGSilentp.A506A1
SYNCRIPPRADchr68632485386324853CAMissense_Mutationp.R498M1
SYNCRIPCOADchr68632479286324792GASilentp.R420R1
SYNCRIPLIHCchr68632452286324522AGSilent1
SYNCRIPSKCMchr68633381286333812GAMissense_Mutationp.R131C1
SYNCRIPTHCAchr68632474386324743CTMissense_Mutation1
SYNCRIPLUSCchr68632479386324793CAMissense_Mutationp.R518L1
SYNCRIPHNSCchr68632454786324547TAMissense_Mutation1
SYNCRIPLUADchr68634998786349987CGSilentp.G109G1
SYNCRIPKIRCchr68632477586324775GCNonsense_Mutationp.S524X1
SYNCRIPPRADchr68632903386329033TANonsense_Mutationp.K371*1
SYNCRIPCOADchr68632912686329126GASilentp.L242L1
SYNCRIPLIHCchr68635020986350209CAMissense_Mutation1
SYNCRIPSKCMchr68632480086324800GAMissense_Mutationp.P418S1
SYNCRIPLUSCchr68632900986329009CGMissense_Mutationp.D379H1
SYNCRIPSTADchr68632906686329066GANonsense_Mutationp.Q360X1
SYNCRIPHNSCchr68634676586346765CGMissense_Mutation1
SYNCRIPKIRPchr68632473786324740CTCG-Frame_Shift_Delp.536_537del1
SYNCRIPPRADchr68632470186324701CAMissense_Mutationp.G549W1
SYNCRIPSTADchr68632863386328634-TFrame_Shift_Insp.D395fs1
SYNCRIPTHCAchr68632474386324743CTMissense_Mutationp.V437I1
SYNCRIPCOADchr68633381686333816TGMissense_Mutationp.E129D1
SYNCRIPLIHCchr68633379786333797TCMissense_Mutationp.I234V1
SYNCRIPSKCMchr68632455186324553CAC-In_Frame_Delp.563_564del1
SYNCRIPHNSCchr68632479586324795GASilent1
SYNCRIPLUSCchr68632467086324670CTMissense_Mutationp.G559E1
SYNCRIPREADchr68633374286333742TGMissense_Mutationp.K154T1
SYNCRIPSTADchr68632906686329066GANonsense_Mutationp.Q360*1
SYNCRIPTHCAchr68632474386324743CTMissense_Mutationp.V535I1
SYNCRIPCOADchr68635003086350030A-Frame_Shift_Delp.L95fs1
SYNCRIPLIHCchr68635016486350164CTSilentp.Q89Q1
SYNCRIPLUADchr68632469286324692CTMissense_Mutationp.G552S1
SYNCRIPSKCMchr68632470486324704GAMissense_Mutationp.R548C1
SYNCRIPHNSCchr68633381886333818CTMissense_Mutation1
SYNCRIPOVchr68632494086324940TCMissense_Mutationp.Y469C1
SYNCRIPSTADchr68635000686350007-TGTIn_Frame_Insp.R103delinsNR1
SYNCRIPLGGchr68632488686324886CGMissense_Mutationp.G487A1
SYNCRIPSTADchr68632909386329093CANonsense_Mutationp.E351*1
SYNCRIPTHYMchr68634675786346757GTSilent1
SYNCRIPCOADchr68635018086350180TCMissense_Mutationp.D84G1
SYNCRIPLUADchr68634674286346742TGMissense_Mutationp.R203S1
SYNCRIPSKCMchr68632459986324599GANonsense_Mutationp.Q583*1
SYNCRIPACCchr68632465086324650TCMissense_Mutationp.K566E1
SYNCRIPOVchr68638133686381336GAMissense_Mutationp.R577W1
SYNCRIPSTADchr68632909386329093CANonsense_Mutationp.E351X1
SYNCRIPCESCchr68633224086332240GTMissense_Mutation1
SYNCRIPLGGchr68633229786332297CTMissense_Mutationp.R304H1
SYNCRIPSARCchr68635024086350240GTMissense_Mutation1
SYNCRIPSTADchr68632863486328635-TFrame_Shift_Insp.K394fs1
SYNCRIPTHYMchr68632470386324703CAMissense_Mutation1
SYNCRIPDLBCchr68633221086332210ACMissense_Mutationp.V333G1
SYNCRIPSKCMchr68633222686332226CGMissense_Mutationp.D328H1
SYNCRIPBLCAchr68634996086349963TCCT-Frame_Shift_Del1
SYNCRIPOVchr68632476286324762ACSilentp.G5281
SYNCRIPLGGchr68633229786332297CTMissense_Mutation1
SYNCRIPSTADchr68635000786350008-TGTIn_Frame_Insp.R103T1
SYNCRIPTHYMchr68634675786346757GTSilentp.L198L1
SYNCRIPSKCMchr68632480086324800GAMissense_Mutationp.P516S1
SYNCRIPBLCAchr68632505886325058CTMissense_Mutationp.D430N1
SYNCRIPCESCchr68632474886324748CGMissense_Mutationp.R533T1
SYNCRIPLGGchr68632488686324886CGMissense_Mutation1
SYNCRIPSTADchr68632906686329066GANonsense_Mutation1
SYNCRIPTHYMchr68633221286332212CTSilentp.E332E1
SYNCRIPBLCAchr68634996086349963TCCT-Frame_Shift_Delp.KG117fs1
SYNCRIPHNSCchr68633381886333818CTMissense_Mutationp.E227K1
SYNCRIPPAADchr68632472886324728CANonsense_Mutationp.G540*1

check buttonCopy number variation (CNV) of SYNCRIP
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across SYNCRIP
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
101351N/AAW274852ATP13A1chr1919756133+SYNCRIPchr686352841+
101351GBMTCGA-4W-AA9T-01ADAAM1chr1459758024+SYNCRIPchr686329135-
101351N/ABC019360EIF3Mchr1132605399-SYNCRIPchr686352608-
101351Non-CancerTCGA-CG-5721-11AFUCA2chr6143818525-SYNCRIPchr686333830-
101351N/AAI557045KLHL4chrX86827819-SYNCRIPchr686326953-
101351N/ACF134851MAP4K5chr1450938878-SYNCRIPchr686323920+
101351N/ABU151397RAVER1chr1910433837-SYNCRIPchr686328614-
101351HNSCTCGA-CV-6962SNX14chr686298581-SYNCRIPchr686325065-
101351HNSCTCGA-CV-6962SNX14chr686303297-SYNCRIPchr686325065-
97964BRCATCGA-E2-A14VSYNCRIPchr686352514-CDK19chr6111067404-
97964BRCATCGA-E2-A14V-01ASYNCRIPchr686352514-CDK19chr6111067403-
97964BRCATCGA-E2-A14V-01ASYNCRIPchr686352515-CDK19chr6111067404-
97964BRCATCGA-E2-A14V-01ASYNCRIPchr686352515-CDK19chr6111095140-
103262Non-CancerERR315404SYNCRIPchr686352515-EEF1A1chr674229779-
88398PRADTCGA-VN-A88QSYNCRIPchr686333694-EPB41L2chr6131161738-
88398N/ABI495805SYNCRIPchr686336985-KIF3Bchr2030922814-
100295N/ABD310766SYNCRIPchr686346797-LPPchr3187893846+
96066OVTCGA-13-1497-01ASYNCRIPchr686346685-SEMA3Achr783739905-
101351N/AAA846916SYNCRIPchr686322014+SYNCRIPchr686322014-
101353N/AAW022188ZMYM2chr1320663255+SYNCRIPchr686336986+


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
HNSCSYNCRIP0.00757011671179170.21
UVMSYNCRIP0.02448651974986920.66
PAADSYNCRIP0.03929040677010551

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
LIHCSYNCRIP0.001233331958491540.039
LUSCSYNCRIP0.03555923501271011
THCASYNCRIP0.000407584487274850.013
BRCASYNCRIP0.007930293933521270.25
PCPGSYNCRIP0.03359024204923161

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source
C0023418leukemia1CTD_human