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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PAIP1 (NCBI Gene ID:10605)

Gene Summary

Gene Summary

Gene Information	Gene Name: PAIP1
	Gene ID: 10605
	Gene Symbol	PAIP1
	Gene ID	10605
	Gene Name	poly(A) binding protein interacting protein 1
	Synonyms	-
	Cytomap	5p12
	Type of Gene	protein-coding
	Description	polyadenylate-binding protein-interacting protein 1PABC1-interacting protein 1PABP-interacting protein 1PAIP-1
	Modification date	20200313
	UniProtAcc	Q9H074

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
PAIP1	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'PAIP1[title] AND translation [title] AND human.'

Gene	Title	PMID
PAIP1	Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†	30295753

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000306846	43529887	43529981	Frame-shift
ENST00000306846	43533839	43533894	Frame-shift
ENST00000306846	43536920	43537046	In-frame
ENST00000306846	43539025	43539137	Frame-shift
ENST00000306846	43543105	43543218	Frame-shift
ENST00000306846	43547829	43548015	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000306846	43536920	43537046	2799	1080	1205	479	282	324
ENST00000306846	43547829	43548015	2799	669	854	479	145	207

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9H074	145	207	1	479	Chain	ID=PRO_0000058177;Note=Polyadenylate-binding protein-interacting protein 1
Q9H074	282	324	1	479	Chain	ID=PRO_0000058177;Note=Polyadenylate-binding protein-interacting protein 1
Q9H074	145	207	159	376	Domain	Note=MIF4G
Q9H074	282	324	159	376	Domain	Note=MIF4G
Q9H074	145	207	158	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RK6
Q9H074	145	207	173	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RK6
Q9H074	145	207	176	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RK6
Q9H074	145	207	194	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RK6
Q9H074	282	324	288	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RK6
Q9H074	282	324	294	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RK6
Q9H074	282	324	313	336	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3RK6

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	PAIP1	-5.71279064132007	0.00220467399393826
BRCA	PAIP1	1.33783668607252	1.59729685534959e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
OV	PAIP1	hsa-miR-182-5p	94	0.345086655852472	0.0126057143920277
UCEC	PAIP1	hsa-miR-182-5p	94	0.369595110771581	0.0321435165682908

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
COAD	PAIP1	0.045047492	0.032785328

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PAIP1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
LUSC	TF	PAIP1	ZNF131	0.804592176	8.17E-127
SKCM	TF	PAIP1	ZNF131	0.821445497	3.36E-117
THYM	Cell metabolism gene	PAIP1	PDHX	0.800509803	1.88E-28
THYM	Cell metabolism gene	PAIP1	PNPLA8	0.808829457	1.91E-29
THYM	Cell metabolism gene	PAIP1	SUCLA2	0.818548612	1.14E-30
THYM	Cell metabolism gene	PAIP1	PIP5K1A	0.825646914	1.30E-31
THYM	Cell metabolism gene	PAIP1	BCKDHB	0.827689532	6.84E-32
THYM	Cell metabolism gene	PAIP1	AUH	0.830690139	2.62E-32
THYM	Cell metabolism gene	PAIP1	PIK3R4	0.83248791	1.46E-32
THYM	Cell metabolism gene	PAIP1	AASDHPPT	0.834778297	6.88E-33
THYM	Cell metabolism gene	PAIP1	TRMT11	0.850062783	3.28E-35
THYM	Cell metabolism gene	PAIP1	PAPSS1	0.85696551	2.41E-36
THYM	CGC	PAIP1	NFE2L2	0.801323607	1.51E-28
THYM	CGC	PAIP1	MLLT10	0.817138237	1.73E-30
THYM	CGC	PAIP1	PALB2	0.818862832	1.04E-30
THYM	Epifactor	PAIP1	ADNP	0.801223139	1.55E-28
THYM	Epifactor	PAIP1	HLTF	0.803512931	8.35E-29
THYM	Epifactor	PAIP1	TAF2	0.805018273	5.52E-29
THYM	Epifactor	PAIP1	TADA1	0.805580071	4.73E-29
THYM	Epifactor	PAIP1	MLLT10	0.817138237	1.73E-30
THYM	Epifactor	PAIP1	RNF2	0.821819594	4.24E-31
THYM	Epifactor	PAIP1	AEBP2	0.853586515	8.80E-36
THYM	IUPHAR	PAIP1	NFE2L2	0.801323607	1.51E-28
THYM	IUPHAR	PAIP1	PIP5K1A	0.825646914	1.30E-31
THYM	IUPHAR	PAIP1	NEK4	0.825828693	1.23E-31
THYM	IUPHAR	PAIP1	PIK3R4	0.83248791	1.46E-32
THYM	IUPHAR	PAIP1	MAP4K3	0.835269668	5.84E-33
THYM	Kinase	PAIP1	NEK4	0.825828693	1.23E-31
THYM	Kinase	PAIP1	PIK3R4	0.83248791	1.46E-32
THYM	Kinase	PAIP1	MAP4K3	0.835269668	5.84E-33
THYM	TF	PAIP1	ZBTB43	0.800461376	1.91E-28
THYM	TF	PAIP1	ADNP	0.801223139	1.55E-28
THYM	TF	PAIP1	NFE2L2	0.801323607	1.51E-28
THYM	TF	PAIP1	ZNF468	0.822607495	3.33E-31
THYM	TF	PAIP1	TOPORS	0.828264017	5.70E-32
THYM	TF	PAIP1	ZNF28	0.831450393	2.05E-32
THYM	TF	PAIP1	ZNF280B	0.831827774	1.81E-32
THYM	TF	PAIP1	ZFP30	0.8454211	1.77E-34
THYM	TF	PAIP1	AEBP2	0.853586515	8.80E-36
THYM	TF	PAIP1	ZNF567	0.854648994	5.88E-36
THYM	TF	PAIP1	ZNF136	0.875300692	1.13E-39
THYM	TSG	PAIP1	HLTF	0.803512931	8.35E-29
THYM	TSG	PAIP1	PALB2	0.818862832	1.04E-30
THYM	TSG	PAIP1	TOPORS	0.828264017	5.70E-32
THYM	TSG	PAIP1	RCHY1	0.846971109	1.01E-34
UCS	Cell metabolism gene	PAIP1	PDHX	0.800509803	1.88E-28
UCS	Cell metabolism gene	PAIP1	PNPLA8	0.808829457	1.91E-29
UCS	Cell metabolism gene	PAIP1	SUCLA2	0.818548612	1.14E-30
UCS	Cell metabolism gene	PAIP1	PIP5K1A	0.825646914	1.30E-31
UCS	Cell metabolism gene	PAIP1	BCKDHB	0.827689532	6.84E-32
UCS	Cell metabolism gene	PAIP1	AUH	0.830690139	2.62E-32
UCS	Cell metabolism gene	PAIP1	PIK3R4	0.83248791	1.46E-32
UCS	Cell metabolism gene	PAIP1	AASDHPPT	0.834778297	6.88E-33
UCS	Cell metabolism gene	PAIP1	TRMT11	0.850062783	3.28E-35
UCS	Cell metabolism gene	PAIP1	PAPSS1	0.85696551	2.41E-36
UCS	CGC	PAIP1	NFE2L2	0.801323607	1.51E-28
UCS	CGC	PAIP1	MLLT10	0.817138237	1.73E-30
UCS	CGC	PAIP1	PALB2	0.818862832	1.04E-30
UCS	Epifactor	PAIP1	ADNP	0.801223139	1.55E-28
UCS	Epifactor	PAIP1	HLTF	0.803512931	8.35E-29
UCS	Epifactor	PAIP1	TAF2	0.805018273	5.52E-29
UCS	Epifactor	PAIP1	TADA1	0.805580071	4.73E-29
UCS	Epifactor	PAIP1	MLLT10	0.817138237	1.73E-30
UCS	Epifactor	PAIP1	RNF2	0.821819594	4.24E-31
UCS	Epifactor	PAIP1	AEBP2	0.853586515	8.80E-36
UCS	IUPHAR	PAIP1	NFE2L2	0.801323607	1.51E-28
UCS	IUPHAR	PAIP1	PIP5K1A	0.825646914	1.30E-31
UCS	IUPHAR	PAIP1	NEK4	0.825828693	1.23E-31
UCS	IUPHAR	PAIP1	PIK3R4	0.83248791	1.46E-32
UCS	IUPHAR	PAIP1	MAP4K3	0.835269668	5.84E-33
UCS	Kinase	PAIP1	NEK4	0.825828693	1.23E-31
UCS	Kinase	PAIP1	PIK3R4	0.83248791	1.46E-32
UCS	Kinase	PAIP1	MAP4K3	0.835269668	5.84E-33
UCS	TF	PAIP1	ZBTB43	0.800461376	1.91E-28
UCS	TF	PAIP1	ADNP	0.801223139	1.55E-28
UCS	TF	PAIP1	NFE2L2	0.801323607	1.51E-28
UCS	TF	PAIP1	ZNF468	0.822607495	3.33E-31
UCS	TF	PAIP1	TOPORS	0.828264017	5.70E-32
UCS	TF	PAIP1	ZNF28	0.831450393	2.05E-32
UCS	TF	PAIP1	ZNF280B	0.831827774	1.81E-32
UCS	TF	PAIP1	ZFP30	0.8454211	1.77E-34
UCS	TF	PAIP1	AEBP2	0.853586515	8.80E-36
UCS	TF	PAIP1	ZNF567	0.854648994	5.88E-36
UCS	TF	PAIP1	ZNF136	0.875300692	1.13E-39
UCS	TSG	PAIP1	HLTF	0.803512931	8.35E-29
UCS	TSG	PAIP1	PALB2	0.818862832	1.04E-30
UCS	TSG	PAIP1	TOPORS	0.828264017	5.70E-32
UCS	TSG	PAIP1	RCHY1	0.846971109	1.01E-34
UVM	Cell metabolism gene	PAIP1	SLC19A2	0.800911753	4.73E-19
UVM	Cell metabolism gene	PAIP1	SDHD	0.801907869	3.97E-19
UVM	Cell metabolism gene	PAIP1	GPD2	0.802044875	3.88E-19
UVM	Cell metabolism gene	PAIP1	SRP72	0.8022702	3.72E-19
UVM	Cell metabolism gene	PAIP1	RFK	0.803107809	3.21E-19
UVM	Cell metabolism gene	PAIP1	POLR2B	0.803619697	2.93E-19
UVM	Cell metabolism gene	PAIP1	HMGCR	0.804131788	2.67E-19
UVM	Cell metabolism gene	PAIP1	POLR3F	0.8047312	2.40E-19
UVM	Cell metabolism gene	PAIP1	LYPLA1	0.806436983	1.77E-19
UVM	Cell metabolism gene	PAIP1	IPMK	0.806648524	1.70E-19
UVM	Cell metabolism gene	PAIP1	PIK3C3	0.807657488	1.42E-19
UVM	Cell metabolism gene	PAIP1	ALG13	0.808507769	1.21E-19
UVM	Cell metabolism gene	PAIP1	GNPNAT1	0.808635154	1.18E-19
UVM	Cell metabolism gene	PAIP1	CPOX	0.808795545	1.15E-19
UVM	Cell metabolism gene	PAIP1	DDX20	0.809281771	1.05E-19
UVM	Cell metabolism gene	PAIP1	MINPP1	0.809935233	9.32E-20
UVM	Cell metabolism gene	PAIP1	PMPCB	0.811524474	6.94E-20
UVM	Cell metabolism gene	PAIP1	PIP5K1A	0.811890966	6.48E-20
UVM	Cell metabolism gene	PAIP1	LPGAT1	0.815043146	3.57E-20
UVM	Cell metabolism gene	PAIP1	SEH1L	0.816773665	2.56E-20
UVM	Cell metabolism gene	PAIP1	NUP50	0.819863909	1.41E-20
UVM	Cell metabolism gene	PAIP1	COL4A3BP	0.820791124	1.17E-20
UVM	Cell metabolism gene	PAIP1	FPGT	0.821907135	9.39E-21
UVM	Cell metabolism gene	PAIP1	GLS	0.822045499	9.14E-21
UVM	Cell metabolism gene	PAIP1	MED7	0.822074766	9.09E-21
UVM	Cell metabolism gene	PAIP1	NUPL1	0.824073086	6.09E-21
UVM	Cell metabolism gene	PAIP1	PLA2G12A	0.824220653	5.91E-21
UVM	Cell metabolism gene	PAIP1	FAR1	0.825229127	4.82E-21
UVM	Cell metabolism gene	PAIP1	DCP2	0.825494019	4.57E-21
UVM	Cell metabolism gene	PAIP1	PSMD14	0.827691577	2.91E-21
UVM	Cell metabolism gene	PAIP1	GPAM	0.828192721	2.63E-21
UVM	Cell metabolism gene	PAIP1	PSMD10	0.82965515	1.94E-21
UVM	Cell metabolism gene	PAIP1	PANK3	0.83037796	1.67E-21
UVM	Cell metabolism gene	PAIP1	TXNRD1	0.831430374	1.34E-21
UVM	Cell metabolism gene	PAIP1	MTM1	0.832954495	9.66E-22
UVM	Cell metabolism gene	PAIP1	NUP54	0.834260456	7.30E-22
UVM	Cell metabolism gene	PAIP1	UGGT2	0.83478756	6.52E-22
UVM	Cell metabolism gene	PAIP1	SUCLA2	0.834917616	6.34E-22
UVM	Cell metabolism gene	PAIP1	ACADSB	0.836751536	4.25E-22
UVM	Cell metabolism gene	PAIP1	PPAT	0.837202886	3.85E-22
UVM	Cell metabolism gene	PAIP1	MANEA	0.837768967	3.40E-22
UVM	Cell metabolism gene	PAIP1	DBT	0.838215934	3.08E-22
UVM	Cell metabolism gene	PAIP1	SRP19	0.838505059	2.89E-22
UVM	Cell metabolism gene	PAIP1	NUP107	0.838536047	2.87E-22
UVM	Cell metabolism gene	PAIP1	SEC24B	0.838587385	2.84E-22
UVM	Cell metabolism gene	PAIP1	NFYB	0.839657775	2.24E-22
UVM	Cell metabolism gene	PAIP1	PIK3CA	0.83996386	2.09E-22
UVM	Cell metabolism gene	PAIP1	CSGALNACT2	0.840031501	2.06E-22
UVM	Cell metabolism gene	PAIP1	XPO1	0.840844921	1.71E-22
UVM	Cell metabolism gene	PAIP1	CLOCK	0.841917395	1.35E-22
UVM	Cell metabolism gene	PAIP1	BPNT1	0.843808469	8.74E-23
UVM	Cell metabolism gene	PAIP1	DIS3	0.844724527	7.08E-23
UVM	Cell metabolism gene	PAIP1	L2HGDH	0.846571816	4.61E-23
UVM	Cell metabolism gene	PAIP1	TNPO1	0.846635968	4.54E-23
UVM	Cell metabolism gene	PAIP1	ENOPH1	0.847801684	3.45E-23
UVM	Cell metabolism gene	PAIP1	ETNK1	0.848222681	3.12E-23
UVM	Cell metabolism gene	PAIP1	GXYLT1	0.849248578	2.45E-23
UVM	Cell metabolism gene	PAIP1	HMGCS1	0.850350861	1.88E-23
UVM	Cell metabolism gene	PAIP1	UGP2	0.850712875	1.72E-23
UVM	Cell metabolism gene	PAIP1	EDEM3	0.85083193	1.67E-23
UVM	Cell metabolism gene	PAIP1	PIGA	0.851573135	1.40E-23
UVM	Cell metabolism gene	PAIP1	DCK	0.853332562	9.09E-24
UVM	Cell metabolism gene	PAIP1	PIKFYVE	0.853711133	8.28E-24
UVM	Cell metabolism gene	PAIP1	RANBP2	0.8553352	5.53E-24
UVM	Cell metabolism gene	PAIP1	PRKAA1	0.857469279	3.23E-24
UVM	Cell metabolism gene	PAIP1	ALG10B	0.859894387	1.74E-24
UVM	Cell metabolism gene	PAIP1	PHAX	0.860562153	1.46E-24
UVM	Cell metabolism gene	PAIP1	CCT2	0.861490462	1.15E-24
UVM	Cell metabolism gene	PAIP1	AGPS	0.861766716	1.07E-24
UVM	Cell metabolism gene	PAIP1	AASDHPPT	0.863807004	6.22E-25
UVM	Cell metabolism gene	PAIP1	MED17	0.864786839	4.79E-25
UVM	Cell metabolism gene	PAIP1	VBP1	0.865594909	3.85E-25
UVM	Cell metabolism gene	PAIP1	FBXL3	0.866818249	2.76E-25
UVM	Cell metabolism gene	PAIP1	CNOT8	0.87146894	7.57E-26
UVM	Cell metabolism gene	PAIP1	ACSL4	0.871534577	7.43E-26
UVM	Cell metabolism gene	PAIP1	GNPDA2	0.876520928	1.75E-26
UVM	Cell metabolism gene	PAIP1	NUDT12	0.879069473	8.16E-27
UVM	Cell metabolism gene	PAIP1	PPP1CB	0.881499149	3.88E-27
UVM	Cell metabolism gene	PAIP1	MTMR6	0.88261676	2.74E-27
UVM	Cell metabolism gene	PAIP1	IDI1	0.887562954	5.63E-28
UVM	Cell metabolism gene	PAIP1	C1GALT1	0.889886544	2.61E-28
UVM	Cell metabolism gene	PAIP1	GRPEL2	0.890092692	2.44E-28
UVM	Cell metabolism gene	PAIP1	PNPLA8	0.891819122	1.36E-28
UVM	Cell metabolism gene	PAIP1	NAMPT	0.897495061	1.85E-29
UVM	Cell metabolism gene	PAIP1	SACM1L	0.900597649	5.94E-30
UVM	Cell metabolism gene	PAIP1	PSMC6	0.902062243	3.43E-30
UVM	Cell metabolism gene	PAIP1	NUPL2	0.915981176	1.14E-32
UVM	CGC	PAIP1	ATRX	0.800364183	5.21E-19
UVM	CGC	PAIP1	ZCCHC8	0.801852235	4.01E-19
UVM	CGC	PAIP1	SDHD	0.801907869	3.97E-19
UVM	CGC	PAIP1	ARHGAP5	0.802485469	3.58E-19
UVM	CGC	PAIP1	ATM	0.802575902	3.53E-19
UVM	CGC	PAIP1	TRIM33	0.806359269	1.79E-19
UVM	CGC	PAIP1	RAD21	0.810039606	9.14E-20
UVM	CGC	PAIP1	USP8	0.814420022	4.02E-20
UVM	CGC	PAIP1	PWWP2A	0.815655033	3.18E-20
UVM	CGC	PAIP1	BMPR1A	0.817548808	2.21E-20
UVM	CGC	PAIP1	ARID2	0.817938428	2.05E-20
UVM	CGC	PAIP1	BAZ1A	0.82144996	1.03E-20
UVM	CGC	PAIP1	SMAD4	0.82588178	4.22E-21
UVM	CGC	PAIP1	APC	0.827718631	2.90E-21
UVM	CGC	PAIP1	ABI1	0.828035176	2.71E-21
UVM	CGC	PAIP1	PALB2	0.828200956	2.62E-21
UVM	CGC	PAIP1	DDX10	0.83428139	7.27E-22
UVM	CGC	PAIP1	FIP1L1	0.834396299	7.09E-22
UVM	CGC	PAIP1	RGPD3	0.835409794	5.70E-22
UVM	CGC	PAIP1	BCLAF1	0.839875296	2.13E-22
UVM	CGC	PAIP1	PIK3CA	0.83996386	2.09E-22
UVM	CGC	PAIP1	ATF1	0.839985088	2.08E-22
UVM	CGC	PAIP1	XPO1	0.840844921	1.71E-22
UVM	CGC	PAIP1	ERCC4	0.842727714	1.12E-22
UVM	CGC	PAIP1	GOLGA5	0.846438235	4.75E-23
UVM	CGC	PAIP1	CUL3	0.84730183	3.88E-23
UVM	CGC	PAIP1	RAD17	0.847666463	3.56E-23
UVM	CGC	PAIP1	MLLT10	0.848076379	3.23E-23
UVM	CGC	PAIP1	ETNK1	0.848222681	3.12E-23
UVM	CGC	PAIP1	FBXO11	0.848252476	3.10E-23
UVM	CGC	PAIP1	MALT1	0.850215944	1.94E-23
UVM	CGC	PAIP1	DICER1	0.850701069	1.73E-23
UVM	CGC	PAIP1	CREB1	0.854491325	6.83E-24
UVM	CGC	PAIP1	DEK	0.855180303	5.75E-24
UVM	CGC	PAIP1	RANBP2	0.8553352	5.53E-24
UVM	CGC	PAIP1	HSP90AA1	0.856333634	4.31E-24
UVM	CGC	PAIP1	KIF5B	0.858436913	2.53E-24
UVM	CGC	PAIP1	POT1	0.861296199	1.21E-24
UVM	CGC	PAIP1	DDX5	0.861451872	1.16E-24
UVM	CGC	PAIP1	PMS1	0.864356583	5.37E-25
UVM	CGC	PAIP1	CDC73	0.871453389	7.60E-26
UVM	CGC	PAIP1	SF3B1	0.874745719	2.95E-26
UVM	CGC	PAIP1	PHF6	0.87834819	1.01E-26
UVM	CGC	PAIP1	MSH2	0.87862402	9.33E-27
UVM	CGC	PAIP1	SUZ12	0.889622252	2.85E-28
UVM	CGC	PAIP1	STAG2	0.891970702	1.29E-28
UVM	Epifactor	PAIP1	MYSM1	0.800003656	5.55E-19
UVM	Epifactor	PAIP1	ATRX	0.800364183	5.21E-19
UVM	Epifactor	PAIP1	ANKRD32	0.801186249	4.51E-19
UVM	Epifactor	PAIP1	ATM	0.802575902	3.53E-19
UVM	Epifactor	PAIP1	DNAJC2	0.803586938	2.95E-19
UVM	Epifactor	PAIP1	SUV39H2	0.803889091	2.79E-19
UVM	Epifactor	PAIP1	MBIP	0.804150583	2.67E-19
UVM	Epifactor	PAIP1	RPS6KA5	0.805004877	2.29E-19
UVM	Epifactor	PAIP1	TAF9B	0.80589408	1.95E-19
UVM	Epifactor	PAIP1	SMYD2	0.805961423	1.93E-19
UVM	Epifactor	PAIP1	CIR1	0.80609543	1.88E-19
UVM	Epifactor	PAIP1	TRIM33	0.806359269	1.79E-19
UVM	Epifactor	PAIP1	SMARCAD1	0.806957544	1.61E-19
UVM	Epifactor	PAIP1	SENP1	0.80744156	1.47E-19
UVM	Epifactor	PAIP1	CDK17	0.807814733	1.38E-19
UVM	Epifactor	PAIP1	UBE2D1	0.808446648	1.23E-19
UVM	Epifactor	PAIP1	PHF14	0.80969554	9.74E-20
UVM	Epifactor	PAIP1	HLTF	0.809873212	9.42E-20
UVM	Epifactor	PAIP1	TAF9	0.811328054	7.19E-20
UVM	Epifactor	PAIP1	UBE2B	0.813079135	5.18E-20
UVM	Epifactor	PAIP1	WAC	0.813584527	4.71E-20
UVM	Epifactor	PAIP1	MPHOSPH8	0.813948694	4.40E-20
UVM	Epifactor	PAIP1	FAM175A	0.814194744	4.20E-20
UVM	Epifactor	PAIP1	CUL4B	0.814762331	3.77E-20
UVM	Epifactor	PAIP1	PHF20L1	0.817118894	2.40E-20
UVM	Epifactor	PAIP1	ARID2	0.817938428	2.05E-20
UVM	Epifactor	PAIP1	RAD54B	0.819798293	1.42E-20
UVM	Epifactor	PAIP1	BAZ1A	0.82144996	1.03E-20
UVM	Epifactor	PAIP1	TDG	0.822896621	7.71E-21
UVM	Epifactor	PAIP1	INO80D	0.824086421	6.07E-21
UVM	Epifactor	PAIP1	UHRF2	0.824138956	6.01E-21
UVM	Epifactor	PAIP1	YAF2	0.824347411	5.76E-21
UVM	Epifactor	PAIP1	HCFC2	0.82521856	4.83E-21
UVM	Epifactor	PAIP1	EPC1	0.826533947	3.69E-21
UVM	Epifactor	PAIP1	USP15	0.827123499	3.27E-21
UVM	Epifactor	PAIP1	DDX21	0.828393549	2.52E-21
UVM	Epifactor	PAIP1	ZBTB33	0.831539253	1.30E-21
UVM	Epifactor	PAIP1	CBX3	0.83239973	1.09E-21
UVM	Epifactor	PAIP1	ATAD2B	0.833055289	9.45E-22
UVM	Epifactor	PAIP1	HMGB1	0.83382831	8.01E-22
UVM	Epifactor	PAIP1	TAF1	0.835232754	5.92E-22
UVM	Epifactor	PAIP1	PHIP	0.835865684	5.16E-22
UVM	Epifactor	PAIP1	OGT	0.835946918	5.07E-22
UVM	Epifactor	PAIP1	CTBP2	0.836056184	4.95E-22
UVM	Epifactor	PAIP1	CHUK	0.838981479	2.60E-22
UVM	Epifactor	PAIP1	NFYB	0.839657775	2.24E-22
UVM	Epifactor	PAIP1	CHD9	0.840178814	1.99E-22
UVM	Epifactor	PAIP1	BRMS1L	0.840470356	1.87E-22
UVM	Epifactor	PAIP1	PARG	0.840738894	1.76E-22
UVM	Epifactor	PAIP1	EPC2	0.841709388	1.41E-22
UVM	Epifactor	PAIP1	CLOCK	0.841917395	1.35E-22
UVM	Epifactor	PAIP1	ARID4A	0.847090514	4.08E-23
UVM	Epifactor	PAIP1	CUL3	0.84730183	3.88E-23
UVM	Epifactor	PAIP1	AEBP2	0.84760973	3.61E-23
UVM	Epifactor	PAIP1	MLLT10	0.848076379	3.23E-23
UVM	Epifactor	PAIP1	ARID4B	0.848520571	2.91E-23
UVM	Epifactor	PAIP1	DDX50	0.850616069	1.76E-23
UVM	Epifactor	PAIP1	ATF2	0.8514893	1.43E-23
UVM	Epifactor	PAIP1	ZMYND11	0.852740096	1.05E-23
UVM	Epifactor	PAIP1	NSL1	0.8529906	9.89E-24
UVM	Epifactor	PAIP1	UCHL5	0.853048768	9.75E-24
UVM	Epifactor	PAIP1	HAT1	0.853729636	8.24E-24
UVM	Epifactor	PAIP1	DNTTIP2	0.854193781	7.35E-24
UVM	Epifactor	PAIP1	RCOR3	0.854655504	6.55E-24
UVM	Epifactor	PAIP1	DEK	0.855180303	5.75E-24
UVM	Epifactor	PAIP1	NIPBL	0.855746535	4.99E-24
UVM	Epifactor	PAIP1	BAZ2B	0.855855456	4.86E-24
UVM	Epifactor	PAIP1	PRKAA1	0.857469279	3.23E-24
UVM	Epifactor	PAIP1	JMJD1C	0.859805232	1.78E-24
UVM	Epifactor	PAIP1	SMEK1	0.860761672	1.39E-24
UVM	Epifactor	PAIP1	PCGF6	0.86167841	1.09E-24
UVM	Epifactor	PAIP1	ZRANB3	0.863951094	5.99E-25
UVM	Epifactor	PAIP1	VRK1	0.865195213	4.29E-25
UVM	Epifactor	PAIP1	MASTL	0.86968348	1.25E-25
UVM	Epifactor	PAIP1	SIRT1	0.871406576	7.70E-26
UVM	Epifactor	PAIP1	CDC73	0.871453389	7.60E-26
UVM	Epifactor	PAIP1	CUL5	0.873130962	4.71E-26
UVM	Epifactor	PAIP1	SF3B1	0.874745719	2.95E-26
UVM	Epifactor	PAIP1	ACTR6	0.877967287	1.14E-26
UVM	Epifactor	PAIP1	TAF7	0.879417219	7.34E-27
UVM	Epifactor	PAIP1	RLIM	0.883725151	1.93E-27
UVM	Epifactor	PAIP1	RMI1	0.884233998	1.65E-27
UVM	Epifactor	PAIP1	TADA1	0.885834821	9.87E-28
UVM	Epifactor	PAIP1	CHD1	0.887359515	6.02E-28
UVM	Epifactor	PAIP1	SUZ12	0.889622252	2.85E-28
UVM	Epifactor	PAIP1	FAM175B	0.893675616	7.17E-29
UVM	Epifactor	PAIP1	YY1	0.898352206	1.36E-29
UVM	Epifactor	PAIP1	SMEK2	0.898887079	1.12E-29
UVM	Epifactor	PAIP1	BRCC3	0.901527686	4.19E-30
UVM	Epifactor	PAIP1	TLK1	0.902555437	2.84E-30
UVM	Epifactor	PAIP1	YEATS4	0.916925379	7.45E-33
UVM	Epifactor	PAIP1	CUL2	0.928184451	3.16E-35
UVM	IUPHAR	PAIP1	SLC19A2	0.800911753	4.73E-19
UVM	IUPHAR	PAIP1	CRBN	0.801598805	4.19E-19
UVM	IUPHAR	PAIP1	ATM	0.802575902	3.53E-19
UVM	IUPHAR	PAIP1	USP1	0.803045985	3.25E-19
UVM	IUPHAR	PAIP1	CLK4	0.803066208	3.23E-19
UVM	IUPHAR	PAIP1	SLC37A3	0.803510121	2.99E-19
UVM	IUPHAR	PAIP1	SUV39H2	0.803889091	2.79E-19
UVM	IUPHAR	PAIP1	HMGCR	0.804131788	2.67E-19
UVM	IUPHAR	PAIP1	RPS6KA5	0.805004877	2.29E-19
UVM	IUPHAR	PAIP1	TAOK3	0.805078181	2.26E-19
UVM	IUPHAR	PAIP1	SMYD2	0.805961423	1.93E-19
UVM	IUPHAR	PAIP1	TRIM33	0.806359269	1.79E-19
UVM	IUPHAR	PAIP1	ABCB10	0.806818746	1.65E-19
UVM	IUPHAR	PAIP1	SENP1	0.80744156	1.47E-19
UVM	IUPHAR	PAIP1	PIK3C3	0.807657488	1.42E-19
UVM	IUPHAR	PAIP1	CDK17	0.807814733	1.38E-19
UVM	IUPHAR	PAIP1	BMPR2	0.808159763	1.29E-19
UVM	IUPHAR	PAIP1	ADAM17	0.811510669	6.95E-20
UVM	IUPHAR	PAIP1	PIP5K1A	0.811890966	6.48E-20
UVM	IUPHAR	PAIP1	NR3C1	0.81523663	3.44E-20
UVM	IUPHAR	PAIP1	NR2C1	0.816462556	2.72E-20
UVM	IUPHAR	PAIP1	BMPR1A	0.817548808	2.21E-20
UVM	IUPHAR	PAIP1	CSNK1A1	0.818149266	1.97E-20
UVM	IUPHAR	PAIP1	MAP3K2	0.8190838	1.64E-20
UVM	IUPHAR	PAIP1	PLK4	0.820537123	1.23E-20
UVM	IUPHAR	PAIP1	BAZ1A	0.82144996	1.03E-20
UVM	IUPHAR	PAIP1	SLC25A24	0.821741918	9.71E-21
UVM	IUPHAR	PAIP1	GLS	0.822045499	9.14E-21
UVM	IUPHAR	PAIP1	MAPK6	0.822733459	7.97E-21
UVM	IUPHAR	PAIP1	PLA2G12A	0.824220653	5.91E-21
UVM	IUPHAR	PAIP1	TNKS2	0.825706284	4.37E-21
UVM	IUPHAR	PAIP1	PSMD14	0.827691577	2.91E-21
UVM	IUPHAR	PAIP1	STK17A	0.828891316	2.27E-21
UVM	IUPHAR	PAIP1	PRMT3	0.829263732	2.10E-21
UVM	IUPHAR	PAIP1	METAP2	0.831575529	1.29E-21
UVM	IUPHAR	PAIP1	ATAD2B	0.833055289	9.45E-22
UVM	IUPHAR	PAIP1	TAF1	0.835232754	5.92E-22
UVM	IUPHAR	PAIP1	PHIP	0.835865684	5.16E-22
UVM	IUPHAR	PAIP1	MAGT1	0.836988986	4.04E-22
UVM	IUPHAR	PAIP1	PPAT	0.837202886	3.85E-22
UVM	IUPHAR	PAIP1	CHUK	0.838981479	2.60E-22
UVM	IUPHAR	PAIP1	NEK1	0.839732293	2.20E-22
UVM	IUPHAR	PAIP1	PIK3CA	0.83996386	2.09E-22
UVM	IUPHAR	PAIP1	XPO1	0.840844921	1.71E-22
UVM	IUPHAR	PAIP1	PRPF4B	0.841157897	1.60E-22
UVM	IUPHAR	PAIP1	EGLN1	0.84172188	1.41E-22
UVM	IUPHAR	PAIP1	CLOCK	0.841917395	1.35E-22
UVM	IUPHAR	PAIP1	IRAK4	0.843855043	8.65E-23
UVM	IUPHAR	PAIP1	FBXO11	0.848252476	3.10E-23
UVM	IUPHAR	PAIP1	MALT1	0.850215944	1.94E-23
UVM	IUPHAR	PAIP1	HMGCS1	0.850350861	1.88E-23
UVM	IUPHAR	PAIP1	NEK7	0.850673318	1.74E-23
UVM	IUPHAR	PAIP1	SLK	0.851860067	1.30E-23
UVM	IUPHAR	PAIP1	MFN1	0.852061781	1.24E-23
UVM	IUPHAR	PAIP1	ZMYND11	0.852740096	1.05E-23
UVM	IUPHAR	PAIP1	RIOK2	0.853194284	9.40E-24
UVM	IUPHAR	PAIP1	PIKFYVE	0.853711133	8.28E-24
UVM	IUPHAR	PAIP1	HAT1	0.853729636	8.24E-24
UVM	IUPHAR	PAIP1	RIOK3	0.853785324	8.13E-24
UVM	IUPHAR	PAIP1	TRPM7	0.854119034	7.49E-24
UVM	IUPHAR	PAIP1	BAZ2B	0.855855456	4.86E-24
UVM	IUPHAR	PAIP1	HSP90AA1	0.856333634	4.31E-24
UVM	IUPHAR	PAIP1	XIAP	0.857360346	3.32E-24
UVM	IUPHAR	PAIP1	PRKAA1	0.857469279	3.23E-24
UVM	IUPHAR	PAIP1	VRK2	0.857869823	2.92E-24
UVM	IUPHAR	PAIP1	JMJD1C	0.859805232	1.78E-24
UVM	IUPHAR	PAIP1	MAP4K3	0.860884418	1.34E-24
UVM	IUPHAR	PAIP1	TBK1	0.863349111	7.03E-25
UVM	IUPHAR	PAIP1	SCYL2	0.864398924	5.31E-25
UVM	IUPHAR	PAIP1	VRK1	0.865195213	4.29E-25
UVM	IUPHAR	PAIP1	MASTL	0.86968348	1.25E-25
UVM	IUPHAR	PAIP1	SIRT1	0.871406576	7.70E-26
UVM	IUPHAR	PAIP1	SLC30A9	0.87345527	4.29E-26
UVM	IUPHAR	PAIP1	USP14	0.882032711	3.29E-27
UVM	IUPHAR	PAIP1	YES1	0.883515115	2.07E-27
UVM	IUPHAR	PAIP1	BIRC2	0.886879865	7.03E-28
UVM	IUPHAR	PAIP1	IDI1	0.887562954	5.63E-28
UVM	IUPHAR	PAIP1	SLC25A46	0.896497612	2.65E-29
UVM	IUPHAR	PAIP1	TLK1	0.902555437	2.84E-30
UVM	IUPHAR	PAIP1	CSNK1G3	0.903033837	2.37E-30
UVM	IUPHAR	PAIP1	STK38L	0.904654664	1.27E-30
UVM	IUPHAR	PAIP1	SLC30A5	0.907879265	3.52E-31
UVM	Kinase	PAIP1	ATM	0.802575902	3.53E-19
UVM	Kinase	PAIP1	CLK4	0.803066208	3.23E-19
UVM	Kinase	PAIP1	RPS6KA5	0.805004877	2.29E-19
UVM	Kinase	PAIP1	TAOK3	0.805078181	2.26E-19
UVM	Kinase	PAIP1	TRIM33	0.806359269	1.79E-19
UVM	Kinase	PAIP1	PAN3	0.807244428	1.53E-19
UVM	Kinase	PAIP1	CDK17	0.807814733	1.38E-19
UVM	Kinase	PAIP1	BMPR2	0.808159763	1.29E-19
UVM	Kinase	PAIP1	BMPR1A	0.817548808	2.21E-20
UVM	Kinase	PAIP1	CSNK1A1	0.818149266	1.97E-20
UVM	Kinase	PAIP1	MAP3K2	0.8190838	1.64E-20
UVM	Kinase	PAIP1	PLK4	0.820537123	1.23E-20
UVM	Kinase	PAIP1	COL4A3BP	0.820791124	1.17E-20
UVM	Kinase	PAIP1	BAZ1A	0.82144996	1.03E-20
UVM	Kinase	PAIP1	MAPK6	0.822733459	7.97E-21
UVM	Kinase	PAIP1	STK17A	0.828891316	2.27E-21
UVM	Kinase	PAIP1	TAF1	0.835232754	5.92E-22
UVM	Kinase	PAIP1	CHUK	0.838981479	2.60E-22
UVM	Kinase	PAIP1	NEK1	0.839732293	2.20E-22
UVM	Kinase	PAIP1	PRPF4B	0.841157897	1.60E-22
UVM	Kinase	PAIP1	IRAK4	0.843855043	8.65E-23
UVM	Kinase	PAIP1	NEK7	0.850673318	1.74E-23
UVM	Kinase	PAIP1	SLK	0.851860067	1.30E-23
UVM	Kinase	PAIP1	RIOK2	0.853194284	9.40E-24
UVM	Kinase	PAIP1	RIOK3	0.853785324	8.13E-24
UVM	Kinase	PAIP1	TRPM7	0.854119034	7.49E-24
UVM	Kinase	PAIP1	PRKAA1	0.857469279	3.23E-24
UVM	Kinase	PAIP1	VRK2	0.857869823	2.92E-24
UVM	Kinase	PAIP1	MAP4K3	0.860884418	1.34E-24
UVM	Kinase	PAIP1	TBK1	0.863349111	7.03E-25
UVM	Kinase	PAIP1	SCYL2	0.864398924	5.31E-25
UVM	Kinase	PAIP1	VRK1	0.865195213	4.29E-25
UVM	Kinase	PAIP1	MASTL	0.86968348	1.25E-25
UVM	Kinase	PAIP1	YES1	0.883515115	2.07E-27
UVM	Kinase	PAIP1	TLK1	0.902555437	2.84E-30
UVM	Kinase	PAIP1	CSNK1G3	0.903033837	2.37E-30
UVM	Kinase	PAIP1	STK38L	0.904654664	1.27E-30
UVM	TF	PAIP1	MYSM1	0.800003656	5.55E-19
UVM	TF	PAIP1	ZNF485	0.800457482	5.12E-19
UVM	TF	PAIP1	ZNF558	0.801383838	4.35E-19
UVM	TF	PAIP1	ZNF225	0.801526046	4.25E-19
UVM	TF	PAIP1	RLF	0.801723562	4.10E-19
UVM	TF	PAIP1	ZNF230	0.802511011	3.57E-19
UVM	TF	PAIP1	ZNF449	0.804640686	2.44E-19
UVM	TF	PAIP1	ZNF44	0.805154164	2.23E-19
UVM	TF	PAIP1	ZFP30	0.805373586	2.14E-19
UVM	TF	PAIP1	ZNF277	0.805564588	2.07E-19
UVM	TF	PAIP1	ZNF525	0.806126522	1.87E-19
UVM	TF	PAIP1	ZNF292	0.807711707	1.40E-19
UVM	TF	PAIP1	ZNF587	0.80866683	1.18E-19
UVM	TF	PAIP1	ZNF613	0.808807818	1.15E-19
UVM	TF	PAIP1	ZNF200	0.809697236	9.74E-20
UVM	TF	PAIP1	ZNF10	0.80976134	9.62E-20
UVM	TF	PAIP1	ELF1	0.809781338	9.59E-20
UVM	TF	PAIP1	ZNF644	0.811213979	7.35E-20
UVM	TF	PAIP1	ZNF611	0.811499151	6.97E-20
UVM	TF	PAIP1	JRKL	0.812687841	5.58E-20
UVM	TF	PAIP1	ZNF23	0.813579474	4.72E-20
UVM	TF	PAIP1	ZNF326	0.813649092	4.65E-20
UVM	TF	PAIP1	NKRF	0.814008869	4.35E-20
UVM	TF	PAIP1	ADNP2	0.815109495	3.53E-20
UVM	TF	PAIP1	NR3C1	0.81523663	3.44E-20
UVM	TF	PAIP1	PRDM10	0.81556732	3.23E-20
UVM	TF	PAIP1	ZNF83	0.816324909	2.80E-20
UVM	TF	PAIP1	NR2C1	0.816462556	2.72E-20
UVM	TF	PAIP1	ZNF20	0.816680557	2.61E-20
UVM	TF	PAIP1	ZNF484	0.817114972	2.40E-20
UVM	TF	PAIP1	ZNF222	0.817528426	2.22E-20
UVM	TF	PAIP1	ZNF765	0.817596916	2.19E-20
UVM	TF	PAIP1	ARID2	0.817938428	2.05E-20
UVM	TF	PAIP1	ZNF782	0.81895766	1.68E-20
UVM	TF	PAIP1	ZNF25	0.819307028	1.57E-20
UVM	TF	PAIP1	ZNF564	0.820110111	1.34E-20
UVM	TF	PAIP1	ZNF680	0.82130098	1.06E-20
UVM	TF	PAIP1	ZNF808	0.821534219	1.01E-20
UVM	TF	PAIP1	ZNF566	0.821933484	9.34E-21
UVM	TF	PAIP1	TOPORS	0.824301164	5.82E-21
UVM	TF	PAIP1	ZNF627	0.82456765	5.51E-21
UVM	TF	PAIP1	ZFX	0.825271044	4.78E-21
UVM	TF	PAIP1	SMAD4	0.82588178	4.22E-21
UVM	TF	PAIP1	ZNF92	0.826095066	4.04E-21
UVM	TF	PAIP1	ZNF443	0.826097236	4.04E-21
UVM	TF	PAIP1	ZNF675	0.826230386	3.93E-21
UVM	TF	PAIP1	ZNF84	0.827458537	3.06E-21
UVM	TF	PAIP1	VEZF1	0.827784375	2.86E-21
UVM	TF	PAIP1	ZNF614	0.829071069	2.19E-21
UVM	TF	PAIP1	ZNF235	0.829118556	2.17E-21
UVM	TF	PAIP1	PRMT3	0.829263732	2.10E-21
UVM	TF	PAIP1	ZNF700	0.829767748	1.89E-21
UVM	TF	PAIP1	ZNF518A	0.830314754	1.69E-21
UVM	TF	PAIP1	ZNF283	0.830671562	1.57E-21
UVM	TF	PAIP1	ZNF780B	0.830788141	1.53E-21
UVM	TF	PAIP1	ZBTB33	0.831539253	1.30E-21
UVM	TF	PAIP1	CREBZF	0.831776979	1.24E-21
UVM	TF	PAIP1	ZNF182	0.832676062	1.03E-21
UVM	TF	PAIP1	PURB	0.832754103	1.01E-21
UVM	TF	PAIP1	ZNF160	0.833120722	9.32E-22
UVM	TF	PAIP1	ZNF234	0.833668402	8.29E-22
UVM	TF	PAIP1	ZNF585A	0.83427056	7.29E-22
UVM	TF	PAIP1	ZNF708	0.835189735	5.97E-22
UVM	TF	PAIP1	ZNF606	0.835448354	5.65E-22
UVM	TF	PAIP1	ZNF260	0.835776646	5.26E-22
UVM	TF	PAIP1	ZNF658	0.835883907	5.14E-22
UVM	TF	PAIP1	ZNF223	0.836612679	4.38E-22
UVM	TF	PAIP1	ZNF91	0.836618565	4.38E-22
UVM	TF	PAIP1	ZNF226	0.837105858	3.94E-22
UVM	TF	PAIP1	ZNF45	0.83732354	3.75E-22
UVM	TF	PAIP1	ZNF146	0.837760476	3.41E-22
UVM	TF	PAIP1	THAP1	0.838164632	3.12E-22
UVM	TF	PAIP1	TMF1	0.838181869	3.11E-22
UVM	TF	PAIP1	ZNF43	0.838379214	2.97E-22
UVM	TF	PAIP1	NFYB	0.839657775	2.24E-22
UVM	TF	PAIP1	ATF1	0.839985088	2.08E-22
UVM	TF	PAIP1	ZNF354B	0.840100735	2.03E-22
UVM	TF	PAIP1	ZNF600	0.840889315	1.70E-22
UVM	TF	PAIP1	THAP2	0.840889902	1.70E-22
UVM	TF	PAIP1	ZNF37A	0.840970508	1.67E-22
UVM	TF	PAIP1	ZNF138	0.841477469	1.49E-22
UVM	TF	PAIP1	CLOCK	0.841917395	1.35E-22
UVM	TF	PAIP1	ZNF354A	0.843141059	1.02E-22
UVM	TF	PAIP1	MEF2A	0.843148549	1.02E-22
UVM	TF	PAIP1	ZNF555	0.843167274	1.01E-22
UVM	TF	PAIP1	ZNF184	0.843216443	1.00E-22
UVM	TF	PAIP1	ZNF143	0.844061529	8.25E-23
UVM	TF	PAIP1	DMTF1	0.844101238	8.17E-23
UVM	TF	PAIP1	ZNF780A	0.844499459	7.46E-23
UVM	TF	PAIP1	ZNF470	0.844617718	7.26E-23
UVM	TF	PAIP1	ZNF12	0.844922035	6.76E-23
UVM	TF	PAIP1	ZNF721	0.845792154	5.53E-23
UVM	TF	PAIP1	FOXN2	0.845850849	5.45E-23
UVM	TF	PAIP1	ZNF253	0.847321371	3.86E-23
UVM	TF	PAIP1	ZNF227	0.847500293	3.70E-23
UVM	TF	PAIP1	AEBP2	0.84760973	3.61E-23
UVM	TF	PAIP1	ZNF441	0.848061683	3.24E-23
UVM	TF	PAIP1	ZNF440	0.84826791	3.09E-23
UVM	TF	PAIP1	ZNF320	0.848491989	2.93E-23
UVM	TF	PAIP1	ZNF527	0.84888246	2.67E-23
UVM	TF	PAIP1	ZNF347	0.850581376	1.78E-23
UVM	TF	PAIP1	ZC3H8	0.850991408	1.61E-23
UVM	TF	PAIP1	ZNF397	0.851440821	1.44E-23
UVM	TF	PAIP1	ATF2	0.8514893	1.43E-23
UVM	TF	PAIP1	ZNF507	0.851970017	1.27E-23
UVM	TF	PAIP1	ZNF195	0.852306591	1.17E-23
UVM	TF	PAIP1	ZNF569	0.853377395	8.99E-24
UVM	TF	PAIP1	ZNF75D	0.854166463	7.40E-24
UVM	TF	PAIP1	ZNF148	0.854273925	7.21E-24
UVM	TF	PAIP1	CREB1	0.854491325	6.83E-24
UVM	TF	PAIP1	BAZ2B	0.855855456	4.86E-24
UVM	TF	PAIP1	ZNF510	0.857205006	3.46E-24
UVM	TF	PAIP1	ZNF26	0.857685368	3.06E-24
UVM	TF	PAIP1	ZBTB6	0.858887559	2.25E-24
UVM	TF	PAIP1	RBAK	0.859631574	1.86E-24
UVM	TF	PAIP1	ZBTB11	0.859892139	1.74E-24
UVM	TF	PAIP1	HDX	0.8599503	1.71E-24
UVM	TF	PAIP1	ZNF461	0.860361926	1.54E-24
UVM	TF	PAIP1	ZNF268	0.861003107	1.30E-24
UVM	TF	PAIP1	PCGF6	0.86167841	1.09E-24
UVM	TF	PAIP1	ZNF24	0.861903188	1.03E-24
UVM	TF	PAIP1	ZBTB41	0.862094896	9.79E-25
UVM	TF	PAIP1	ZNF430	0.864345673	5.39E-25
UVM	TF	PAIP1	ZNF41	0.868745521	1.62E-25
UVM	TF	PAIP1	ZNF302	0.869131158	1.46E-25
UVM	TF	PAIP1	ZNF280C	0.869861594	1.19E-25
UVM	TF	PAIP1	ZFP14	0.870086337	1.12E-25
UVM	TF	PAIP1	AHCTF1	0.870260966	1.06E-25
UVM	TF	PAIP1	ZNF280D	0.871962943	6.58E-26
UVM	TF	PAIP1	ZNF140	0.872445871	5.73E-26
UVM	TF	PAIP1	GABPA	0.874428756	3.23E-26
UVM	TF	PAIP1	ZNF800	0.8747036	2.99E-26
UVM	TF	PAIP1	ZNF267	0.874719159	2.97E-26
UVM	TF	PAIP1	ZNF14	0.876781628	1.62E-26
UVM	TF	PAIP1	ZNF431	0.876948419	1.54E-26
UVM	TF	PAIP1	ZNF383	0.87697466	1.53E-26
UVM	TF	PAIP1	LIN54	0.877064681	1.49E-26
UVM	TF	PAIP1	ZNF181	0.878345135	1.02E-26
UVM	TF	PAIP1	ELF2	0.878563456	9.51E-27
UVM	TF	PAIP1	ZNF567	0.879336729	7.52E-27
UVM	TF	PAIP1	ZNF254	0.879762069	6.61E-27
UVM	TF	PAIP1	ZNF420	0.881410975	3.98E-27
UVM	TF	PAIP1	THAP6	0.88149553	3.88E-27
UVM	TF	PAIP1	THAP9	0.881804466	3.53E-27
UVM	TF	PAIP1	ZNF701	0.882443487	2.89E-27
UVM	TF	PAIP1	NFXL1	0.883092512	2.36E-27
UVM	TF	PAIP1	ZNF845	0.884160994	1.68E-27
UVM	TF	PAIP1	IKZF5	0.885540435	1.08E-27
UVM	TF	PAIP1	ZNF432	0.886715582	7.42E-28
UVM	TF	PAIP1	ZNF33A	0.887768278	5.26E-28
UVM	TF	PAIP1	SMAD5	0.889543352	2.93E-28
UVM	TF	PAIP1	MYNN	0.890002423	2.51E-28
UVM	TF	PAIP1	ZNF761	0.891295282	1.62E-28
UVM	TF	PAIP1	ZNF791	0.891855379	1.34E-28
UVM	TF	PAIP1	SP3	0.892192503	1.20E-28
UVM	TF	PAIP1	CEBPZ	0.895176708	4.24E-29
UVM	TF	PAIP1	ZBTB1	0.89670518	2.46E-29
UVM	TF	PAIP1	YY1	0.898352206	1.36E-29
UVM	TF	PAIP1	GPBP1	0.898788508	1.16E-29
UVM	TF	PAIP1	ZNF180	0.900586875	5.97E-30
UVM	TF	PAIP1	ZNF468	0.900664193	5.80E-30
UVM	TF	PAIP1	ZNF136	0.901760263	3.84E-30
UVM	TF	PAIP1	THAP5	0.902804256	2.58E-30
UVM	TF	PAIP1	ZNF28	0.909768177	1.63E-31
UVM	TF	PAIP1	ZNF131	0.923370915	3.61E-34
UVM	TSG	PAIP1	SDHD	0.801907869	3.97E-19
UVM	TSG	PAIP1	GTPBP4	0.802119044	3.82E-19
UVM	TSG	PAIP1	ATM	0.802575902	3.53E-19
UVM	TSG	PAIP1	RFWD2	0.802941609	3.31E-19
UVM	TSG	PAIP1	APAF1	0.8049488	2.31E-19
UVM	TSG	PAIP1	ZNF292	0.807711707	1.40E-19
UVM	TSG	PAIP1	BMPR2	0.808159763	1.29E-19
UVM	TSG	PAIP1	SKP2	0.809365491	1.03E-19
UVM	TSG	PAIP1	HLTF	0.809873212	9.42E-20
UVM	TSG	PAIP1	NEDD4	0.811201488	7.37E-20
UVM	TSG	PAIP1	PNN	0.812119593	6.21E-20
UVM	TSG	PAIP1	PTPN2	0.812637552	5.63E-20
UVM	TSG	PAIP1	ANXA7	0.81520652	3.46E-20
UVM	TSG	PAIP1	BMPR1A	0.817548808	2.21E-20
UVM	TSG	PAIP1	USP33	0.817925099	2.05E-20
UVM	TSG	PAIP1	ARID2	0.817938428	2.05E-20
UVM	TSG	PAIP1	CSNK1A1	0.818149266	1.97E-20
UVM	TSG	PAIP1	WDR11	0.818788704	1.74E-20
UVM	TSG	PAIP1	TMEFF1	0.820035557	1.36E-20
UVM	TSG	PAIP1	UHRF2	0.824138956	6.01E-21
UVM	TSG	PAIP1	TOPORS	0.824301164	5.82E-21
UVM	TSG	PAIP1	SMAD4	0.82588178	4.22E-21
UVM	TSG	PAIP1	APC	0.827718631	2.90E-21
UVM	TSG	PAIP1	RB1CC1	0.827951239	2.76E-21
UVM	TSG	PAIP1	PALB2	0.828200956	2.62E-21
UVM	TSG	PAIP1	CCAR1	0.829672634	1.93E-21
UVM	TSG	PAIP1	MLH3	0.830493093	1.63E-21
UVM	TSG	PAIP1	ECT2	0.838500557	2.89E-22
UVM	TSG	PAIP1	CHUK	0.838981479	2.60E-22
UVM	TSG	PAIP1	EGLN1	0.84172188	1.41E-22
UVM	TSG	PAIP1	DMTF1	0.844101238	8.17E-23
UVM	TSG	PAIP1	COPS2	0.847944626	3.33E-23
UVM	TSG	PAIP1	GORAB	0.848937334	2.63E-23
UVM	TSG	PAIP1	FAM188A	0.849538244	2.28E-23
UVM	TSG	PAIP1	DICER1	0.850701069	1.73E-23
UVM	TSG	PAIP1	ZMYND11	0.852740096	1.05E-23
UVM	TSG	PAIP1	KRIT1	0.853720651	8.26E-24
UVM	TSG	PAIP1	SMCHD1	0.855353648	5.51E-24
UVM	TSG	PAIP1	PRKAA1	0.857469279	3.23E-24
UVM	TSG	PAIP1	RBBP8	0.859401794	1.97E-24
UVM	TSG	PAIP1	RINT1	0.860035603	1.68E-24
UVM	TSG	PAIP1	GGNBP2	0.861341938	1.19E-24
UVM	TSG	PAIP1	INTS6	0.870522042	9.89E-26
UVM	TSG	PAIP1	SIRT1	0.871406576	7.70E-26
UVM	TSG	PAIP1	CDC73	0.871453389	7.60E-26
UVM	TSG	PAIP1	CUL5	0.873130962	4.71E-26
UVM	TSG	PAIP1	DCLRE1A	0.873323196	4.45E-26
UVM	TSG	PAIP1	PHF6	0.87834819	1.01E-26
UVM	TSG	PAIP1	MSH2	0.87862402	9.33E-27
UVM	TSG	PAIP1	VEZT	0.881661394	3.69E-27
UVM	TSG	PAIP1	TANK	0.883323129	2.19E-27
UVM	TSG	PAIP1	LIN9	0.887072756	6.61E-28
UVM	TSG	PAIP1	CHD1	0.887359515	6.02E-28
UVM	TSG	PAIP1	SUZ12	0.889622252	2.85E-28
UVM	TSG	PAIP1	PPM1A	0.892440827	1.10E-28
UVM	TSG	PAIP1	CUL2	0.928184451	3.16E-35

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUAD	PAIP1	EIF4A2	1.8359785836448	0.000162905479402723
THCA	PAIP1	PARN	1.04396980067497	0.000304188719124466
COAD	PAIP1	PARN	-2.63498150551249	0.00197160243988037
CHOL	PAIP1	PABPC1	-4.56272528815353	0.00390625
PRAD	PAIP1	PAIP2	-1.03296562711068	0.00620723523605432
KICH	PAIP1	CNOT3	-1.1461250404339	0.00882232189178467
BLCA	PAIP1	PABPC1	1.31485302792746	0.0180816650390625
CHOL	PAIP1	PABPC1L	2.78331172494241	0.01953125
ESCA	PAIP1	EIF4A1	-1.24538073199285	0.0419921875
LUAD	PAIP1	PABPC1L	-2.51583026501524	1.30692790027182e-05
BRCA	PAIP1	EIF4B	-2.16032742029696	2.35556737304054e-22
LIHC	PAIP1	PABPC1	-1.72076961362188	2.98009622125841e-06
LIHC	PAIP1	CNOT3	-1.23300348731276	3.17814170396599e-08
LUSC	PAIP1	PABPC1L	-2.50538171229714	3.79466966402315e-05
STAD	PAIP1	PABPC1L	-2.43245436541992	4.02145087718964e-06
LIHC	PAIP1	PABPC1L	-2.77562492714404	6.17267413816717e-05
KICH	PAIP1	EIF4E	1.61675210562671	6.55651092529297e-06
KICH	PAIP1	PABPC1L	2.22531868187715	7.49826431274414e-05
KIRC	PAIP1	EIF4B	1.14997140510474	7.59366366705366e-09
KIRC	PAIP1	PARN	-1.24669594753579	7.99520634435384e-07
KICH	PAIP1	EIF4A1	1.14485583309571	8.16583633422851e-06
PRAD	PAIP1	PABPC1	-2.10200318363476	8.55379952759014e-07
BRCA	PAIP1	CNOT3	-2.12666858749727	9.14937084127887e-14

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PAIP1

PABPC1, EIF4A1, USP12, CSDE1, SYNCRIP, HNRNPD, UBR5, CUL3, CAND1, UPF2, NUBP2, CBX6, ADSL, PDCD4, WWP2, BMI1, TRA2A, HNRNPDL, DND1, ILF2, LUC7L2, RBMX, MKRN2, STAU2, PABPC1L, ZCCHC3, FTSJ3, RPS15, H2AFX, SF3B4, PAIP2, EIF3B, EIF3G, EIF3A, HSPA4L, NUP50, PPM1G, TPD52, Pabpc1, Ubr5, ELAVL2, CELF5, GSPT2, SREK1, ORF21, WDR77, BICD2, SNRNP70, RND1, MYB, EMC2, N, nsp2, nsp9, nsp3, DDX19B, ASCC2, CNOT1, CNOT3, RQCD1, LARP4B, PABPC4, TDRD3, TDRD7, TOP3B, UPF1, ASCC1, HELZ, ASCC3, TNRC6B, CNOT10, LARP4, CTIF, PRNP, NDN, RBM45, OGT, DDRGK1, FZR1, SMAD4, DAZL, HNRNPCL1, FAM120A, RBMS2, PAIP2B, SNIP1, PABPC5, HNRNPC, PER1, PUM2, LARP1, IREB2, PABPC4L, CASC3, SUGP2, MKRN1, CLK3, IGF2BP3, NCBP1, ZNF326, YBX1, SUPV3L1, IGF2BP2, MTERF3, TRUB2, APOBEC3F, WBSCR16, SRRM2, PTCD1, MOV10, KIF1C, CCDC9, ZC3H18, RNPS1, HNRNPL, SRSF10, LARP1B, ZFR, CDKN2AIP, C17orf85, DHX36, PNN, SRRT, SRRM1, NBR1, SQSTM1, OPTN,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PAIP1	KIRP	chr5	43555937	43555937	A	-	Frame_Shift_Del	p.Y144fs	4
PAIP1	UCEC	chr5	43547955	43547955	A	C	Missense_Mutation	p.L166V	3
PAIP1	LUAD	chr5	43537010	43537010	T	A	Missense_Mutation	p.I295F	3
PAIP1	UCEC	chr5	43529910	43529910	C	T	Missense_Mutation	p.D442N	3
PAIP1	PAAD	chr5	43533874	43533874	T	C	Silent	p.T406T	3
PAIP1	HNSC	chr5	43539127	43539127	C	T	Missense_Mutation	p.E249K	3
PAIP1	BLCA	chr5	43547975	43547975	G	C	Nonsense_Mutation	p.S159*	3
PAIP1	HNSC	chr5	43527498	43527498	C	G	Missense_Mutation	p.E474Q	2
PAIP1	SKCM	chr5	43556095	43556095	G	C	Missense_Mutation	p.T91R	2
PAIP1	BLCA	chr5	43547922	43547922	C	G	Missense_Mutation	p.E177Q	2
PAIP1	KIRC	chr5	43543190	43543190	A	T	Missense_Mutation	p.M217K	2
PAIP1	BLCA	chr5	43533846	43533846	C	T	Missense_Mutation	p.D416N	2
PAIP1	UCEC	chr5	43527495	43527495	G	A	Missense_Mutation	p.R475C	2
PAIP1	SARC	chr5	43535014	43535014	C	G	Missense_Mutation		2
PAIP1	UCEC	chr5	43527543	43527543	C	T	Nonsense_Mutation	p.W348*	2
PAIP1	LUAD	chr5	43535667	43535667	C	G	Missense_Mutation	p.E350Q	2
PAIP1	PAAD	chr5	43533874	43533874	T	C	Silent		2
PAIP1	UCEC	chr5	43529902	43529902	G	A	Silent	p.S444	2
PAIP1	KIRC	chr5	43555964	43555964	A	T	Missense_Mutation	p.F135I	2
PAIP1	STAD	chr5	43527569	43527569	T	C	Missense_Mutation	p.Y450C	2
PAIP1	BLCA	chr5	43547879	43547879	A	T	Missense_Mutation	p.V191D	2
PAIP1	SARC	chr5	43535014	43535014	C	G	Missense_Mutation	p.V380L	2
PAIP1	UCEC	chr5	43535057	43535057	C	T	Missense_Mutation	p.M365I	2
PAIP1	STAD	chr5	43556088	43556088	G	A	Silent	p.P93P	2
PAIP1	UCEC	chr5	43535703	43535703	C	A	Nonsense_Mutation	p.G338*	2
PAIP1	PCPG	chr5	43535001	43535001	G	A	Missense_Mutation		2
PAIP1	STAD	chr5	43536983	43536983	G	A	Silent	p.L304L	2
PAIP1	HNSC	chr5	43535702	43535702	C	T	Missense_Mutation	p.G338E	2
PAIP1	UCEC	chr5	43543181	43543181	C	G	Missense_Mutation	p.R220P	2
PAIP1	CESC	chr5	43527498	43527498	C	T	Missense_Mutation		2
PAIP1	ACC	chr5	43539100	43539100	T	C	Missense_Mutation	p.K258E	2
PAIP1	BLCA	chr5	43543211	43543211	G	C	Missense_Mutation	p.S210C	2
PAIP1	HNSC	chr5	43529915	43529915	C	T	Missense_Mutation	p.G440E	2
PAIP1	HNSC	chr5	43527528	43527528	C	G	Missense_Mutation	p.E464Q	2
PAIP1	BLCA	chr5	43556029	43556029	A	T	Missense_Mutation	p.M113K	2
PAIP1	COAD	chr5	43535710	43535710	C	A	Missense_Mutation	p.K223N	1
PAIP1	LUSC	chr5	43536991	43536991	C	T	Missense_Mutation	p.R301Q	1
PAIP1	READ	chr5	43556027	43556027	C	G	Missense_Mutation	p.A2P	1
PAIP1	BLCA	chr5	43539109	43539109	G	C	Missense_Mutation		1
PAIP1	SKCM	chr5	43533857	43533857	A	G	Missense_Mutation	p.F412S	1
PAIP1	COAD	chr5	43539070	43539070	G	T	Missense_Mutation	p.H156N	1
PAIP1	LUSC	chr5	43547830	43547830	C	A	Missense_Mutation	p.Q207_splice	1
PAIP1	READ	chr5	43555938	43555938	A	C	Missense_Mutation	p.S31R	1
PAIP1	BLCA	chr5	43543211	43543211	G	C	Missense_Mutation		1
PAIP1	SKCM	chr5	43536967	43536967	G	A	Missense_Mutation	p.S197F	1
PAIP1	SKCM	chr5	43556007	43556007	T	A	Silent	p.V120V	1
PAIP1	LUAD	chr5	43556025	43556025	A	T	Silent	p.A114A	1
PAIP1	ESCA	chr5	43547975	43547975	G	T	Nonsense_Mutation	p.S159X	1
PAIP1	LUSC	chr5	43547890	43547890	C	T	Silent	p.L187L	1
PAIP1	SARC	chr5	43543217	43543217	G	T	Missense_Mutation		1
PAIP1	BLCA	chr5	43556029	43556029	A	T	Translation_Start_Site		1
PAIP1	KIRC	chr5	43555944	43555944	A	T	Silent	p.S141S	1
PAIP1	SKCM	chr5	43547949	43547949	G	A	Missense_Mutation	p.H56Y	1
PAIP1	STAD	chr5	43543171	43543173	ATT	-	In_Frame_Del		1
PAIP1	BLCA	chr5	43529943	43529943	C	G	Missense_Mutation	p.D431H	1
PAIP1	LUAD	chr5	43535036	43535036	G	C	Silent	p.L372L	1
PAIP1	GBM	chr5	43527541	43527541	G	A	Silent		1
PAIP1	OV	chr5	43539094	43539094	C	A	Missense_Mutation	p.D260Y	1
PAIP1	BLCA	chr5	43547922	43547922	C	G	Missense_Mutation		1
PAIP1	KIRC	chr5	43547861	43547861	A	C	Missense_Mutation	p.L197W	1
PAIP1	SKCM	chr5	43529903	43529903	G	A	Missense_Mutation	p.S444F	1
PAIP1	STAD	chr5	43543171	43543173	ATT	-	In_Frame_Del	p.223_224del	1
PAIP1	BLCA	chr5	43527531	43527531	C	G	Nonstop_Mutation	p.*352Y	1
PAIP1	HNSC	chr5	43535702	43535702	C	T	Missense_Mutation		1
PAIP1	SARC	chr5	43539102	43539102	G	T	Missense_Mutation		1
PAIP1	BLCA	chr5	43533846	43533846	C	T	Missense_Mutation		1
PAIP1	SKCM	chr5	43529889	43529889	G	A	Splice_Site	p.P449_splice	1
PAIP1	LUAD	chr5	43547901	43547901	C	G	Missense_Mutation	p.A184P	1
PAIP1	HNSC	chr5	43527528	43527528	C	G	Missense_Mutation		1
PAIP1	BLCA	chr5	43529943	43529943	C	G	Missense_Mutation		1
PAIP1	KIRC	chr5	43556087	43556087	G	T	Missense_Mutation	p.L94M	1
PAIP1	SKCM	chr5	43529916	43529916	C	T	Missense_Mutation	p.G440R	1
PAIP1	BLCA	chr5	43543124	43543124	C	G	Missense_Mutation	p.R239P	1
PAIP1	LUAD	chr5	43543193	43543193	T	C	Missense_Mutation	p.Y216C	1
PAIP1	HNSC	chr5	43539127	43539127	C	T	Missense_Mutation		1
PAIP1	SKCM	chr5	43529889	43529889	G	A	Missense_Mutation	p.P337S	1
PAIP1	BLCA	chr5	43547879	43547879	A	T	Missense_Mutation		1
PAIP1	SKCM	chr5	43539082	43539082	G	A	Nonsense_Mutation	p.R264*	1
PAIP1	BLCA	chr5	43527531	43527531	C	G	Missense_Mutation	p.E463Q	1
PAIP1	LUAD	chr5	43548014	43548014	T	G	Splice_Site	p.E146_splice	1
PAIP1	SKCM	chr5	43556007	43556007	T	A	Silent	p.V8V	1
PAIP1	BLCA	chr5	43539109	43539109	G	C	Missense_Mutation	p.Q255E	1
PAIP1	LGG	chr5	43535672	43535672	C	A	Missense_Mutation		1
PAIP1	SKCM	chr5	43547949	43547949	G	A	Missense_Mutation	p.H168Y	1
PAIP1	PCPG	chr5	43536935	43536935	C	A	Missense_Mutation		1
PAIP1	STAD	chr5	43543171	43543173	ATT	-	In_Frame_Del	p.N223del	1
PAIP1	LUAD	chr5	43529946	43529946	C	G	Missense_Mutation	p.E430Q	1
PAIP1	SKCM	chr5	43533857	43533857	A	G	Missense_Mutation	p.F300S	1
PAIP1	LIHC	chr5	43543142	43543142	G	-	Frame_Shift_Del	p.P233fs	1
PAIP1	SKCM	chr5	43543198	43543198	G	A	Silent	p.F214F	1
PAIP1	PCPG	chr5	43535001	43535001	G	A	Missense_Mutation	p.S384L	1
PAIP1	TGCT	chr5	43539098	43539098	T	C	Silent	p.K258K	1
PAIP1	CESC	chr5	43527498	43527498	C	T	Missense_Mutation	p.E474K	1
PAIP1	LUAD	chr5	43548014	43548014	T	G	Missense_Mutation	p.E146A	1
PAIP1	ACC	chr5	43539100	43539100	T	C	Missense_Mutation	p.K146E	1
PAIP1	SKCM	chr5	43529903	43529903	G	A	Missense_Mutation	p.S332F	1
PAIP1	LIHC	chr5	43543202	43543202	T	-	Frame_Shift_Del	p.N213fs	1
PAIP1	SKCM	chr5	43536967	43536967	G	A	Missense_Mutation	p.S309F	1
PAIP1	READ	chr5	43535681	43535681	A	C	Missense_Mutation	p.I233S	1
PAIP1	THYM	chr5	43539115	43539115	T	A	Nonsense_Mutation	p.K253X	1
PAIP1	COAD	chr5	43527537	43527537	C	G	Missense_Mutation	p.E349Q	1
PAIP1	LUSC	chr5	43543192	43543192	A	G	Silent	p.Y216Y	1
PAIP1	ACC	chr5	43556100	43556100	C	T	Splice_Site	p.E89_splice	1
PAIP1	SKCM	chr5	43533872	43533872	G	A	Missense_Mutation	p.S295F	1
PAIP1	SKCM	chr5	43533872	43533872	G	A	Missense_Mutation	p.S407F	1
PAIP1	LIHC	chr5	43536968	43536968	A	-	Frame_Shift_Del	p.S309fs	1

Copy number variation (CNV) of PAIP1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PAIP1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
96018	LUAD	TCGA-44-4112	C5orf28	chr5	43483923	-	PAIP1	chr5	43556101	-
96018	LUAD	TCGA-44-4112-01A	C5orf28	chr5	43483924	-	PAIP1	chr5	43556101	-
96018	OV	TCGA-24-1469	HMGCS1	chr5	43307867	-	PAIP1	chr5	43527571	-
96018	OV	TCGA-24-1469	HMGCS1	chr5	43313457	-	PAIP1	chr5	43527571	-
96018	OV	TCGA-24-1469-01A	HMGCS1	chr5	43307868	-	PAIP1	chr5	43527571	-
96018	OV	TCGA-24-1469-01A	HMGCS1	chr5	43313458	-	PAIP1	chr5	43527571	-
96018	N/A	BU734173	HSP90AA1	chr14	102551205	+	PAIP1	chr5	43535707	+
62384	HNSC	TCGA-CQ-A4C9	PAIP1	chr5	43555932	-	C5orf28	chr5	43446659	-
80584	OV	TCGA-13-1506	PAIP1	chr5	43555931	-	DAB2	chr5	39375186	-
80584	OV	TCGA-13-1506-01A	PAIP1	chr5	43555932	-	DAB2	chr5	39375186	-
79079	OV	TCGA-13-0760	PAIP1	chr5	43533839	-	FBXO38	chr5	147817894	+
92935	STAD	TCGA-HU-8604-01A	PAIP1	chr5	43555932	-	FGF10	chr5	44310632	-
101214	N/A	BM709680	PAIP1	chr5	43535707	-	HSP90AA1	chr14	102551205	-
96018	SKCM	TCGA-GF-A6C8-06A	PRELID2	chr5	145144494	-	PAIP1	chr5	43556101	-
96026	BRCA	TCGA-C8-A26W-01A	UBE2D2	chr5	138941400	+	PAIP1	chr5	43556101	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	PAIP1	0.00217321421645542	0.061
KIRP	PAIP1	0.00267806625608248	0.072
READ	PAIP1	0.0171450478243604	0.45
HNSC	PAIP1	0.0393546108638816	0.98
LGG	PAIP1	0.048024561777883	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	PAIP1	0.000208209192824121	0.0069
KICH	PAIP1	0.00584946334160738	0.18
THYM	PAIP1	0.00244477353681776	0.078

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source