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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: IGF2BP1 (NCBI Gene ID:10642)

Gene Summary

Gene Summary

Gene Information	Gene Name: IGF2BP1
	Gene ID: 10642
	Gene Symbol	IGF2BP1
	Gene ID	10642
	Gene Name	insulin like growth factor 2 mRNA binding protein 1
	Synonyms	CRD-BP\|CRDBP\|IMP-1\|IMP1\|VICKZ1\|ZBP1
	Cytomap	17q21.32
	Type of Gene	protein-coding
	Description	insulin-like growth factor 2 mRNA-binding protein 1IGF-II mRNA-binding protein 1IGF2 mRNA-binding protein 1VICKZ family member 1ZBP-1coding region determinant-binding proteininsulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBPzipcode-bi
	Modification date	20200315
	UniProtAcc	Q9NZI8

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IGF2BP1	GO:0017148	negative regulation of translation	9891060
Hgene	IGF2BP1	GO:0070934	CRD-mediated mRNA stabilization	19029303

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
IGF2BP1	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'IGF2BP1[title] AND translation [title] AND human.'

Gene	Title	PMID
IGF2BP1	IGF2BP1 Significantly Enhances Translation Efficiency of Duck Hepatitis A Virus Type 1 without Affecting Viral Replication	31658691

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000290341	47115529	47115811	In-frame
ENST00000290341	47123621	47123735	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000290341	47115529	47115811	8291	736	1017	577	134	227
ENST00000290341	47123621	47123735	8291	1862	1975	577	509	547

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9NZI8	509	547	1	577	Chain	ID=PRO_0000282533;Note=Insulin-like growth factor 2 mRNA-binding protein 1
Q9NZI8	134	227	1	577	Chain	ID=PRO_0000282533;Note=Insulin-like growth factor 2 mRNA-binding protein 1
Q9NZI8	134	227	81	156	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q9NZI8	134	227	195	260	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00117
Q9NZI8	509	547	487	553	Domain	Note=KH 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00117
Q9NZI8	509	547	187	570	Region	Note=Necessary for interaction with ELAVL4 and binding to TAU mRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q9NZI8	134	227	187	570	Region	Note=Necessary for interaction with ELAVL4 and binding to TAU mRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q9NZI8	134	227	181	181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:16964243,PMID:17081983,PMID:20068231,PMID:23186163
Q9NZI8	509	547	528	528	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9NZI8	134	227	135	273	Alternative sequence	ID=VSP_045366;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.2
Q9NZI8	134	227	213	214	Mutagenesis	Note=50-fold decrease in RNA-binding affinity%2C decreased location in cytoplasmic RNP%2C increased nuclear location%3B when associated with 294-E-L-295 and 423-E-L-424. KE->EL;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12921532;Dbxref=PMID:12921532
Q9NZI8	509	547	508	517	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3KRM
Q9NZI8	509	547	520	522	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3KRM
Q9NZI8	509	547	533	541	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3KRM
Q9NZI8	509	547	543	560	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3KRM

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BRCA	IGF2BP1	-1.119264636586	6.55843695441879e-13

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
ACC	IGF2BP1	hsa-miR-93-5p	92	-0.431446639532291	7.1938938810032e-05

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
OV	IGF2BP1	1	2	0.0196369226047744	0.168319892752119	0.236771408855664	0.141202051331158	0.252203956406987

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with IGF2BP1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
KICH	IUPHAR	IGF2BP1	ABCC2	0.807609069	4.01E-22
KICH	TF	IGF2BP1	PITX2	0.822877352	1.45E-23
TGCT	Epifactor	IGF2BP1	AURKA	0.810384152	1.39E-37
TGCT	IUPHAR	IGF2BP1	AURKA	0.810384152	1.39E-37
TGCT	Kinase	IGF2BP1	AURKA	0.810384152	1.39E-37
TGCT	TF	IGF2BP1	ZNF695	0.81523368	2.30E-38
TGCT	TF	IGF2BP1	ARID3B	0.837920074	2.43E-42

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	IGF2BP1	HNRNPU	-3.25414367586013	0.000109195709228516
KIRP	IGF2BP1	ELAVL1	-2.08200657251054	0.000110303983092308
STAD	IGF2BP1	DHX9	-1.35515869279777	0.00016188295558095
THCA	IGF2BP1	IGF2BP3	1.45257168603129	0.000201301008393121
BLCA	IGF2BP1	DHX9	2.25372387794619	0.00026702880859375
KICH	IGF2BP1	HNRNPU	1.45270865891102	0.000376403331756592
HNSC	IGF2BP1	G3BP1	1.15470167292163	0.000481783007217019
PRAD	IGF2BP1	HNRNPU	-3.59255010200453	0.00074054058184854
COAD	IGF2BP1	IGF2BP3	-3.37798053665109	0.0012979805469513
STAD	IGF2BP1	ELAVL1	-2.10141075100184	0.00222697434946895
STAD	IGF2BP1	SYNCRIP	-3.24695040489934	0.00222697434946895
STAD	IGF2BP1	ELAVL4	-4.8156917527045	0.00879816571250558
LUSC	IGF2BP1	CSDE1	-1.33200117661228	0.025379830388344
LIHC	IGF2BP1	IGF2BP3	-5.69281109771662	1.19111411928294e-07
HNSC	IGF2BP1	CSDE1	-1.92574762956205	1.42088565553422e-05
THCA	IGF2BP1	CSDE1	-1.00581945790421	1.55171507174296e-05
BRCA	IGF2BP1	CSDE1	-1.23575001565702	1.5698167165288e-21
LUAD	IGF2BP1	ELAVL1	-1.15327309311237	1.64690017573449e-06
STAD	IGF2BP1	HNRNPU	-1.26566952320815	2.26888805627823e-05
PRAD	IGF2BP1	G3BP1	-4.29883961189402	2.3360983838936e-06
LIHC	IGF2BP1	HNRNPU	-1.06098658215773	2.35319665208461e-06
THCA	IGF2BP1	SYNCRIP	-3.15946429809988	2.46790521879123e-10
LIHC	IGF2BP1	ELAVL1	-1.11474497929122	3.60241778081952e-05
BRCA	IGF2BP1	YBX1	1.10467241966451	4.8741280959683e-05
KIRC	IGF2BP1	ELAVL4	-1.00392229844369	5.67077560181782e-08
THCA	IGF2BP1	ELAVL1	-1.75446983004742	5.71717197842929e-07
STAD	IGF2BP1	G3BP1	-3.96377290273826	6.0301274061203e-05
LUAD	IGF2BP1	CSDE1	-1.92573954016457	6.46801743847803e-05
KICH	IGF2BP1	IGF2BP3	-2.39951536750512	6.55651092529297e-06
LUAD	IGF2BP1	ELAVL4	-3.36373499023005	6.5815976201703e-06
KIRC	IGF2BP1	IGF2BP3	-2.08624801198165	7.33340683842416e-07
KICH	IGF2BP1	YBX1	1.86923259160472	8.16583633422851e-06
KIRP	IGF2BP1	IGF2BP3	-1.83373480983892	8.74791294336319e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with IGF2BP1

CNBP, PUF60, PRKRA, GSK3B, ARHGDIA, SMYD2, ILK, MEPCE, HNRNPA1, RPAP1, KHDRBS2, CDK9, TP53, TP63, TP73, MYC, AGO4, HDAC5, NOP56, Ybx1, ARRB2, gag, BTRC, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, CAND1, NEDD8, BIRC2, SYNCRIP, FN1, VCAM1, IFIT1, GRB2, ITGA4, CBX6, CBX8, PAN2, BAG3, FBXO6, PARK2, WWOX, IVNS1ABP, STAU1, AURKA, CDKN1A, CEP250, HAUS2, TUBGCP2, TUBGCP3, TUBGCP4, MOV10, NXF1, CUL7, OBSL1, CCDC8, RPS6KB2, IGF2BP2, IGF2BP3, RAB2A, RPL37A, XPO1, HNRNPU, Eif3e, Srp72, MKRN1, ELAVL1, NF2, ZNF746, ELAVL4, ELAVL2, RRS1, MRPS34, GSPT2, NCL, TRIM25, G3BP1, UBE2S, MTF1, FBXO32, CLEC14A, TMPO, EFTUD2, TNIP2, CHD3, CHD4, LARP7, RNF31, TNF, RIOK1, HEXIM1, RUNX1, SNAI1, RECQL4, REST, TBL1XR1, SEC23B, KHSRP, RAB1A, HNRNPD, SEC31A, BMI1, SEC24C, SEC24B, MAN1A1, PTEN, RAB5C, TRAPPC13, HDAC8, RAB1B, TRAPPC12, SAR1A, NCOR1, DCAF7, SEC23IP, NPRL3, HMGCR, ARFGAP2, B3GNT2, TSC2, VPS51, MOGS, ARIH2, IGF2R, EP300, SLC30A5, RICTOR, VPS53, TRAPPC5, TSC1, TRAPPC2, SLC39A7, MAN1B1, Prkaa1, Prkab1, HIST1H2BB, RC3H1, RC3H2, ACTC1, PHB, FAF1, USP14, NR2C2, UBQLN2, PPP1CC, HDAC2, VRK1, VDAC2, OASL, SNRNP70, Dppa3, DUSP14, ITFG1, ARAF, PPP1CA, BIRC3, NFX1, WWP2, BRD7, MATR3, TRIM28, SQSTM1, FERMT2, EHMT2, FLOT1, CD2AP, OGFOD1, TOP2A, NCEH1, PLEKHA4, KCTD10, PINK1, HCVgp1, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, ZC3H18, N, CELF1, DAZL, FAM120A, FUBP3, ALG13, ATXN2, CELF2, CSDE1, DAP3, DDX1, DDX3X, DDX6, EIF4ENIF1, FAM120C, FAM98A, GRSF1, HELZ, LARP4B, LSM12, KIAA0430, FAM195A, MEX3A, MKRN2, MRPS7, MRPS9, OTUD4, PABPC1, PABPC4, PATL1, PCBP2, PRRC2A, PRRC2B, PRRC2C, PTCD3, R3HDM1, RBMS1, RPS15A, SECISBP2, STRAP, TDRD3, TOP3B, UPF1, YTHDF2, ZC3H7A, ZCCHC11, ZCCHC3, ZCCHC6, LSM14A, MEX3B, PUM1, R3HDM2, RBM47, ZC3HAV1, ZFP36, AGO1, CPEB4, G3BP2, LARP4, MCU, MRPS26, PCBP1, RPS2, SMG1, STAU2, AGO2, MRPS18B, MRPS22, MRPS27, MRPS31, YTHDF1, LSM14B, PRMT1, USP10, YTHDF3, CAPRIN1, MRPS23, MRPS28, NUPL2, PARP12, RBMS2, SAMD4B, NEK4, DUX4, CIT, ANLN, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, MNDA, C8orf82, DHX30, METTL17, MTERF3, SLIRP, LRRC59, CDC42, NDN, BIN1, RBM45, Apc2, RBM39, LGALS9, LOC100506797, IFI16, FMR1, LIN28A, OGT, SPOP, UFL1, DDRGK1, RPS20, SERBP1, TLE4, UBQLN1, FZR1, WDR5, PAGE4, NAA40, KLHL20, BTF3, GLI1, FUBP1, APOBEC3B, HECTD1, TRIM71, CPEB1, SOX15, SP7, KLF15, KLF16, KLF4, SOX2, SOX5, SOX6, TLX1, TLX2, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
IGF2BP1	chr17	47076468	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
IGF2BP1	chr17	47103860	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
IGF2BP1	chr17	47117343	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
IGF2BP1	chr17	47117430	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
IGF2BP1	chr17	47132819	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
IGF2BP1	SKCM	chr17	47122386	47122386	C	T	Missense_Mutation	p.R452C	7
IGF2BP1	BRCA	chr17	47117353	47117353	G	A	Missense_Mutation	p.A240T	4
IGF2BP1	SKCM	chr17	47119686	47119686	G	A	Missense_Mutation	p.E342K	4
IGF2BP1	THYM	chr17	47123348	47123348	G	A	Missense_Mutation	p.A498T	3
IGF2BP1	GBM	chr17	47115627	47115627	C	T	Missense_Mutation	p.R167C	3
IGF2BP1	ACC	chr17	47117325	47117325	C	A	Missense_Mutation	p.D230E	3
IGF2BP1	READ	chr17	47115649	47115649	G	A	Missense_Mutation	p.R174Q	3
IGF2BP1	UCEC	chr17	47102991	47102991	T	C	Missense_Mutation	p.I83T	3
IGF2BP1	READ	chr17	47117401	47117401	G	A	Missense_Mutation	p.A256T	3
IGF2BP1	UCEC	chr17	47115720	47115720	C	A	Missense_Mutation	p.L198I	3
IGF2BP1	UCEC	chr17	47121355	47121355	G	T	Missense_Mutation	p.Q409H	3
IGF2BP1	GBM	chr17	47115648	47115648	C	T	Missense_Mutation		3
IGF2BP1	UCS	chr17	47075230	47075230	C	A	Missense_Mutation	p.F41L	3
IGF2BP1	BLCA	chr17	47075134	47075134	C	T	Silent	p.L9L	3
IGF2BP1	PAAD	chr17	47075176	47075176	G	A	Silent	p.A23A	3
IGF2BP1	LIHC	chr17	47117454	47117454	G	A	Splice_Site		3
IGF2BP1	PAAD	chr17	47126761	47126761	G	T	Missense_Mutation	p.Q563H	3
IGF2BP1	PAAD	chr17	47123649	47123649	G	A	Missense_Mutation	p.A519T	3
IGF2BP1	LIHC	chr17	47119724	47119724	T	C	Silent		3
IGF2BP1	PAAD	chr17	47115652	47115652	G	A	Missense_Mutation	p.G175D	3
IGF2BP1	SKCM	chr17	47117396	47117396	C	T	Missense_Mutation	p.S254F	3
IGF2BP1	ESCA	chr17	47103868	47103868	A	G	Missense_Mutation	p.N109S	3
IGF2BP1	LUAD	chr17	47120823	47120823	G	T	Missense_Mutation	p.A371S	3
IGF2BP1	PAAD	chr17	47115672	47115672	C	T	Missense_Mutation	p.P182S	3
IGF2BP1	PRAD	chr17	47121400	47121400	G	-	Frame_Shift_Del	p.K424fs	3
IGF2BP1	STAD	chr17	47123659	47123659	T	C	Missense_Mutation	p.V522A	2
IGF2BP1	LUAD	chr17	47122408	47122408	C	T	Missense_Mutation	p.P459L	2
IGF2BP1	PAAD	chr17	47075176	47075176	G	A	Silent		2
IGF2BP1	LIHC	chr17	47119724	47119724	T	C	Silent	p.D354D	2
IGF2BP1	SARC	chr17	47117380	47117380	A	T	Missense_Mutation		2
IGF2BP1	UCEC	chr17	47121442	47121442	C	T	Silent	p.S438	2
IGF2BP1	STAD	chr17	47121413	47121413	A	G	Missense_Mutation	p.K429E	2
IGF2BP1	PAAD	chr17	47115652	47115652	G	A	Missense_Mutation		2
IGF2BP1	LGG	chr17	47122357	47122357	C	T	Missense_Mutation		2
IGF2BP1	PRAD	chr17	47121347	47121347	A	G	Missense_Mutation	p.M407V	2
IGF2BP1	LIHC	chr17	47115716	47115716	C	-	Frame_Shift_Del	p.I196fs	2
IGF2BP1	SARC	chr17	47122427	47122427	G	A	Silent		2
IGF2BP1	UCEC	chr17	47122409	47122409	G	A	Silent	p.P459	2
IGF2BP1	COAD	chr17	47119662	47119662	G	A	Missense_Mutation	p.E195K	2
IGF2BP1	HNSC	chr17	47076479	47076479	G	C	Missense_Mutation	p.E62Q	2
IGF2BP1	LUAD	chr17	47123696	47123696	G	C	Missense_Mutation	p.Q534H	2
IGF2BP1	CESC	chr17	47123299	47123299	T	G	Silent		2
IGF2BP1	GBM	chr17	47115648	47115648	C	T	Missense_Mutation	p.R174W	2
IGF2BP1	UCEC	chr17	47123690	47123690	C	T	Silent	p.N532	2
IGF2BP1	STAD	chr17	47123723	47123723	C	A	Missense_Mutation	p.F543L	2
IGF2BP1	KIRC	chr17	47103846	47103846	G	C	Missense_Mutation	p.A102P	2
IGF2BP1	PAAD	chr17	47123649	47123649	G	A	Missense_Mutation		2
IGF2BP1	SKCM	chr17	47115560	47115560	G	A	Silent	p.L144L	2
IGF2BP1	CESC	chr17	47103856	47103856	G	C	Missense_Mutation		2
IGF2BP1	SARC	chr17	47117380	47117380	A	T	Missense_Mutation	p.T249S	2
IGF2BP1	STAD	chr17	47126785	47126785	G	-	Frame_Shift_Del	p.Q571fs	2
IGF2BP1	BLCA	chr17	47109291	47109291	G	A	Silent	p.T119T	2
IGF2BP1	KIRC	chr17	47119732	47119732	C	A	Missense_Mutation	p.A357D	2
IGF2BP1	CESC	chr17	47119632	47119632	G	A	Missense_Mutation		2
IGF2BP1	SARC	chr17	47121387	47121387	T	C	Missense_Mutation	p.I420T	2
IGF2BP1	STAD	chr17	47118830	47118830	G	T	Missense_Mutation	p.E303D	2
IGF2BP1	SKCM	chr17	47076519	47076519	C	T	Missense_Mutation	p.P75L	2
IGF2BP1	LUAD	chr17	47115774	47115774	G	A	Missense_Mutation	p.A216T	2
IGF2BP1	UCEC	chr17	47075275	47075275	T	G	Silent	p.T56	2
IGF2BP1	UVM	chr17	47119660	47119660	T	C	Missense_Mutation	p.I333T	2
IGF2BP1	SARC	chr17	47121387	47121387	T	C	Missense_Mutation		2
IGF2BP1	UCEC	chr17	47115724	47115724	G	A	Missense_Mutation	p.R199Q	2
IGF2BP1	CESC	chr17	47121448	47121448	G	C	Missense_Mutation		2
IGF2BP1	UCEC	chr17	47115763	47115763	G	A	Missense_Mutation	p.G212D	2
IGF2BP1	CESC	chr17	47123357	47123357	C	T	Missense_Mutation		2
IGF2BP1	UCEC	chr17	47118747	47118747	G	A	Missense_Mutation	p.E276K	2
IGF2BP1	THYM	chr17	47123348	47123348	G	A	Missense_Mutation		2
IGF2BP1	ESCA	chr17	47075262	47075262	A	T	Missense_Mutation	p.K52M	2
IGF2BP1	SARC	chr17	47115649	47115649	G	A	Missense_Mutation		2
IGF2BP1	UCEC	chr17	47119664	47119664	G	T	Missense_Mutation	p.E334D	2
IGF2BP1	LUAD	chr17	47075138	47075138	G	A	Missense_Mutation	p.E11K	2
IGF2BP1	SKCM	chr17	47115659	47115659	C	T	Silent	p.P177P	2
IGF2BP1	THYM	chr17	47121370	47121370	C	A	Silent		2
IGF2BP1	ESCA	chr17	47103868	47103868	A	G	Missense_Mutation		2
IGF2BP1	SARC	chr17	47121383	47121383	G	T	Missense_Mutation		2
IGF2BP1	UCEC	chr17	47121355	47121355	G	A	Silent	p.Q409	2
IGF2BP1	BLCA	chr17	47103857	47103857	T	C	Silent		1
IGF2BP1	COAD	chr17	47119652	47119652	G	-	Frame_Shift_Del	p.K330fs	1
IGF2BP1	HNSC	chr17	47076494	47076494	C	T	Missense_Mutation	p.R67C	1
IGF2BP1	SKCM	chr17	47119686	47119686	G	A	Missense_Mutation	p.E203K	1
IGF2BP1	LGG	chr17	47126779	47126779	T	C	Silent	p.S569S	1
IGF2BP1	LUAD	chr17	47115590	47115590	C	A	Silent	p.I154I	1
IGF2BP1	PRAD	chr17	47115612	47115612	G	A	Missense_Mutation	p.G162R	1
IGF2BP1	SKCM	chr17	47121384	47121384	C	T	Missense_Mutation	p.A280V	1
IGF2BP1	BLCA	chr17	47109314	47109314	C	G	Missense_Mutation	p.S127C	1
IGF2BP1	CESC	chr17	47074977	47074977	C	T	RNA	NULL	1
IGF2BP1	LUSC	chr17	47122365	47122365	G	T	Nonsense_Mutation	p.E445*	1
IGF2BP1	SKCM	chr17	47123298	47123298	G	A	Missense_Mutation	p.G481D	1
IGF2BP1	SKCM	chr17	47123257	47123257	G	A	Silent	p.Q467Q	1
IGF2BP1	BLCA	chr17	47115661	47115661	G	A	Missense_Mutation		1
IGF2BP1	COAD	chr17	47119661	47119661	C	T	Silent	p.I194I	1
IGF2BP1	HNSC	chr17	47117419	47117419	G	A	Missense_Mutation	p.E262K	1
IGF2BP1	LUAD	chr17	47121403	47121403	G	A	Silent	p.G425G	1
IGF2BP1	SKCM	chr17	47123661	47123661	G	A	Missense_Mutation	p.V384I	1
IGF2BP1	LUAD	chr17	47120887	47120887	G	A	Missense_Mutation	p.G392E	1
IGF2BP1	SKCM	chr17	47122386	47122386	C	T	Missense_Mutation	p.R313C	1
IGF2BP1	THYM	chr17	47121370	47121370	C	A	Silent	p.A414A	1
IGF2BP1	GBM	chr17	47118832	47118832	A	C	Missense_Mutation	p.Q304P	1
IGF2BP1	ACC	chr17	47121377	47121377	G	T	Missense_Mutation	p.V417L	1
IGF2BP1	CESC	chr17	47075053	47075053	C	T	RNA	NULL	1
IGF2BP1	LUSC	chr17	47122358	47122358	A	T	Silent	p.A442A	1
IGF2BP1	SKCM	chr17	47126797	47126797	G	A	Silent	p.R575R	1
IGF2BP1	SKCM	chr17	47126782	47126782	C	T	Silent	p.N570N	1
IGF2BP1	STAD	chr17	47075284	47075284	T	C	Splice_Site	.	1
IGF2BP1	BLCA	chr17	47109314	47109314	C	G	Missense_Mutation		1
IGF2BP1	LUAD	chr17	47122378	47122378	C	A	Missense_Mutation	p.S449Y	1
IGF2BP1	PAAD	chr17	47115672	47115672	C	T	Missense_Mutation		1
IGF2BP1	SKCM	chr17	47118857	47118857	C	T	Silent	p.I173I	1
IGF2BP1	LGG	chr17	47120867	47120867	G	A	Silent		1
IGF2BP1	SKCM	chr17	47122410	47122410	C	T	Missense_Mutation	p.P321S	1
IGF2BP1	BLCA	chr17	47075206	47075206	C	G	Missense_Mutation		1
IGF2BP1	CESC	chr17	47121448	47121448	G	C	Missense_Mutation	p.K440N	1
IGF2BP1	LIHC	chr17	47109320	47109320	G	-	Frame_Shift_Del	p.R129fs	1
IGF2BP1	LUSC	chr17	47126782	47126782	C	A	Missense_Mutation	p.N570K	1
IGF2BP1	SARC	chr17	47122427	47122427	G	A	Splice_Site	p.K465_splice	1
IGF2BP1	SKCM	chr17	47103000	47103000	G	A	Missense_Mutation	p.R86Q	1
IGF2BP1	SKCM	chr17	47123702	47123702	C	T	Silent	p.I536I	1
IGF2BP1	BLCA	chr17	47075206	47075206	C	G	Missense_Mutation	p.F33L	1
IGF2BP1	COAD	chr17	47119664	47119664	G	T	Missense_Mutation	p.E195D	1
IGF2BP1	LUAD	chr17	47115536	47115536	C	T	Silent	p.I136I	1
IGF2BP1	LGG	chr17	47126779	47126779	T	C	Silent		1
IGF2BP1	LUAD	chr17	47115600	47115600	C	G	Missense_Mutation	p.Q158E	1
IGF2BP1	SKCM	chr17	47123661	47123661	G	A	Missense_Mutation	p.V523I	1
IGF2BP1	GBM	chr17	47115627	47115627	C	T	Missense_Mutation		1
IGF2BP1	BLCA	chr17	47122364	47122364	C	A	Silent		1
IGF2BP1	CESC	chr17	47123299	47123299	T	G	Silent	p.G481	1
IGF2BP1	LIHC	chr17	47115688	47115688	C	-	Frame_Shift_Del	p.A187fs	1
IGF2BP1	LUSC	chr17	47120878	47120878	G	T	Missense_Mutation	p.S389I	1
IGF2BP1	SKCM	chr17	47119688	47119688	A	T	Missense_Mutation	p.E342D	1
IGF2BP1	SKCM	chr17	47119628	47119628	C	T	Silent	p.N322N	1
IGF2BP1	UCS	chr17	47075230	47075230	C	A	Missense_Mutation		1
IGF2BP1	COAD	chr17	47122409	47122409	G	A	Silent	p.P320P	1
IGF2BP1	LUAD	chr17	47109330	47109330	C	G	Silent	p.T132T	1
IGF2BP1	PAAD	chr17	47126761	47126761	G	T	Missense_Mutation		1
IGF2BP1	SKCM	chr17	47109315	47109315	C	T	Silent	p.S127S	1
IGF2BP1	LGG	chr17	47119680	47119680	G	A	Missense_Mutation		1
IGF2BP1	LUAD	chr17	47121402	47121402	G	T	Missense_Mutation	p.G425V	1
IGF2BP1	READ	chr17	47115563	47115563	G	T	Missense_Mutation	p.E145D	1
IGF2BP1	BLCA	chr17	47109291	47109291	G	A	Silent		1
IGF2BP1	CESC	chr17	47123357	47123357	C	T	Missense_Mutation	p.R501W	1
IGF2BP1	LIHC	chr17	47118753	47118753	C	-	Frame_Shift_Del	p.P278fs	1
IGF2BP1	SKCM	chr17	47121384	47121384	C	T	Missense_Mutation	p.A419V	1
IGF2BP1	SKCM	chr17	47126800	47126800	G	A	Silent	p.R576R	1
IGF2BP1	COAD	chr17	47123345	47123345	T	G	Missense_Mutation	p.S358A	1
IGF2BP1	KIRP	chr17	47075185	47075185	G	A	Silent	p.K26K	1
IGF2BP1	LUAD	chr17	47123622	47123622	G	T	Splice_Site	p.V510_splice	1
IGF2BP1	READ	chr17	47117344	47117344	G	A	Missense_Mutation	p.A237T	1
IGF2BP1	SKCM	chr17	47076471	47076471	G	A	Splice_Site	p.G59_splice	1
IGF2BP1	CESC	chr17	47074977	47074977	C	T	Missense_Mutation		1
IGF2BP1	GBM	chr17	47118832	47118832	A	C	Missense_Mutation		1
IGF2BP1	BLCA	chr17	47075134	47075134	C	T	Silent		1
IGF2BP1	CESC	chr17	47119632	47119632	G	A	Missense_Mutation	p.E324K	1
IGF2BP1	LIHC	chr17	47076521	47076521	A	-	Frame_Shift_Del	p.K77fs	1
IGF2BP1	SARC	chr17	47118747	47118747	G	T	Nonsense_Mutation	p.E276*	1
IGF2BP1	SKCM	chr17	47118862	47118862	C	T	Splice_Site	p.S314_splice	1
IGF2BP1	SKCM	chr17	47118753	47118753	C	T	Missense_Mutation	p.P278S	1
IGF2BP1	STAD	chr17	47076502	47076502	G	C	Missense_Mutation	p.E69D	1
IGF2BP1	BLCA	chr17	47115536	47115536	C	G	Missense_Mutation	p.I136M	1
IGF2BP1	COAD	chr17	47123665	47123665	C	T	Missense_Mutation	p.P385L	1
IGF2BP1	LGG	chr17	47122357	47122357	C	T	Missense_Mutation	p.A303V	1
IGF2BP1	LUAD	chr17	47122386	47122386	C	G	Missense_Mutation	p.R452G	1
IGF2BP1	SKCM	chr17	47126800	47126800	G	A	Silent	p.R437R	1
IGF2BP1	LIHC	chr17	47119611	47119611	G	T	Missense_Mutation		1
IGF2BP1	LUAD	chr17	47115631	47115631	G	A	Missense_Mutation	p.R168Q	1
IGF2BP1	SKCM	chr17	47123261	47123261	A	G	Missense_Mutation	p.R469G	1
IGF2BP1	GBM	chr17	47122386	47122386	C	T	Missense_Mutation		1
IGF2BP1	BLCA	chr17	47117430	47117430	T	A	Missense_Mutation		1
IGF2BP1	COAD	chr17	47109275	47109275	A	G	Missense_Mutation	p.N114S	1
IGF2BP1	HNSC	chr17	47076479	47076479	G	C	Missense_Mutation		1
IGF2BP1	LIHC	chr17	47115683	47115683	G	-	Frame_Shift_Del	p.A185fs	1
IGF2BP1	SARC	chr17	47122427	47122427	G	A	Silent	p.K465	1
IGF2BP1	SKCM	chr17	47118803	47118803	G	A	Silent	p.K294K	1
IGF2BP1	SKCM	chr17	47126745	47126745	C	G	Missense_Mutation	p.A419G	1
IGF2BP1	STAD	chr17	47075284	47075284	T	C	Splice_Site	p.G59_splice	1
IGF2BP1	BLCA	chr17	47076504	47076504	T	C	Missense_Mutation	p.I70T	1
IGF2BP1	COAD	chr17	47123707	47123707	A	T	Missense_Mutation	p.K399I	1
IGF2BP1	LGG	chr17	47122357	47122357	C	T	Missense_Mutation	p.A442V	1
IGF2BP1	LUAD	chr17	47076513	47076513	C	T	Missense_Mutation	p.S73L	1
IGF2BP1	LUAD	chr17	47117345	47117345	C	T	Missense_Mutation	p.A237V	1
IGF2BP1	SARC	chr17	47075142	47075142	G	T	Missense_Mutation		1
IGF2BP1	SKCM	chr17	47123314	47123314	G	A	Silent	p.V486V	1
IGF2BP1	GBM	chr17	47123715	47123715	G	A	Missense_Mutation		1
IGF2BP1	SKCM	chr17	47115613	47115613	G	A	Missense_Mutation	p.G162E	1
IGF2BP1	BLCA	chr17	47115536	47115536	C	G	Missense_Mutation		1
IGF2BP1	COAD	chr17	47115683	47115683	G	A	Silent	p.A185A	1
IGF2BP1	HNSC	chr17	47123652	47123652	G	A	Missense_Mutation		1
IGF2BP1	LIHC	chr17	47119675	47119675	G	-	Frame_Shift_Del	p.R338fs	1
IGF2BP1	SKCM	chr17	47123261	47123261	A	G	Missense_Mutation	p.R330G	1
IGF2BP1	STAD	chr17	47115628	47115628	G	A	Missense_Mutation	p.R167H	1
IGF2BP1	BLCA	chr17	47121335	47121335	C	G	Missense_Mutation	p.P403A	1
IGF2BP1	LGG	chr17	47119680	47119680	G	A	Missense_Mutation	p.E340K	1
IGF2BP1	LIHC	chr17	47103022	47103022	A	G	Silent	p.R93R	1
IGF2BP1	LUAD	chr17	47075159	47075159	T	A	Missense_Mutation	p.L18M	1
IGF2BP1	SARC	chr17	47123351	47123351	G	T	Missense_Mutation		1
IGF2BP1	SKCM	chr17	47123728	47123728	C	T	Missense_Mutation	p.A545V	1
IGF2BP1	SKCM	chr17	47118857	47118857	C	T	Silent	p.I312I	1
IGF2BP1	CESC	chr17	47115531	47115531	G	T	Missense_Mutation		1
IGF2BP1	HNSC	chr17	47117419	47117419	G	A	Missense_Mutation		1
IGF2BP1	SKCM	chr17	47126745	47126745	C	G	Missense_Mutation	p.A558G	1
IGF2BP1	BLCA	chr17	47076504	47076504	T	C	Missense_Mutation		1
IGF2BP1	COAD	chr17	47115784	47115784	G	A	Missense_Mutation	p.R219H	1
IGF2BP1	HNSC	chr17	47076494	47076494	C	T	Missense_Mutation		1
IGF2BP1	LIHC	chr17	47120836	47120836	T	-	Frame_Shift_Del	p.L375fs	1
IGF2BP1	OV	chr17	44430143	44430143	G	A	Missense_Mutation	p.V13M	1
IGF2BP1	SKCM	chr17	47123314	47123314	G	A	Silent	p.V347V	1
IGF2BP1	LGG	chr17	47103879	47103879	G	A	Splice_Site	p.V113_splice	1
IGF2BP1	LUAD	chr17	47117317	47117317	A	C	Splice_Site		1
IGF2BP1	SKCM	chr17	47118862	47118862	C	T	Missense_Mutation	p.S175L	1
IGF2BP1	BLCA	chr17	47103857	47103857	T	C	Silent	p.G105G	1
IGF2BP1	LIHC	chr17	47117454	47117454	G	A	Splice_Site	.	1
IGF2BP1	LUAD	chr17	47118740	47118740	G	C	Silent	p.T273T	1
IGF2BP1	SKCM	chr17	47121335	47121335	C	T	Missense_Mutation	p.P403S	1
IGF2BP1	SKCM	chr17	47123282	47123282	G	A	Missense_Mutation	p.E476K	1
IGF2BP1	CESC	chr17	47075078	47075078	G	T	Missense_Mutation		1
IGF2BP1	SKCM	chr17	47076520	47076520	C	A	Silent	p.P75P	1
IGF2BP1	BLCA	chr17	47121335	47121335	C	G	Missense_Mutation		1
IGF2BP1	COAD	chr17	47117434	47117434	G	T	Nonsense_Mutation	p.E267X	1
IGF2BP1	HNSC	chr17	47123652	47123652	G	A	Missense_Mutation	p.E520K	1
IGF2BP1	OV	chr17	44430261	44430261	A	G	Missense_Mutation	p.K52R	1
IGF2BP1	SKCM	chr17	47123298	47123298	G	A	Missense_Mutation	p.G342D	1
IGF2BP1	LGG	chr17	47120867	47120867	G	A	Silent	p.P385P	1
IGF2BP1	LUAD	chr17	47122352	47122352	G	T	Splice_Site		1
IGF2BP1	BLCA	chr17	47115661	47115661	G	A	Missense_Mutation	p.R178H	1
IGF2BP1	LIHC	chr17	47120863	47120863	C	T	Missense_Mutation	p.P384L	1
IGF2BP1	LUAD	chr17	47117317	47117317	A	C	Splice_Site	p.K228_splice	1
IGF2BP1	SKCM	chr17	47122410	47122410	C	T	Missense_Mutation	p.P460S	1
IGF2BP1	SKCM	chr17	47075151	47075151	C	T	Missense_Mutation	p.P15L	1
IGF2BP1	CESC	chr17	47075053	47075053	C	T	Missense_Mutation		1

Copy number variation (CNV) of IGF2BP1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across IGF2BP1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100498	N/A	EC559775	B4GALNT2	chr17	47207978	-	IGF2BP1	chr17	47087418	-
100498	N/A	AV700751	BTD	chr3	15684569	+	IGF2BP1	chr17	47113813	+
97139	READ	TCGA-CI-6619-01B	IGF2BP1	chr17	47109335	+	BAIAP2	chr17	79073728	+
100498	N/A	CN430059	IGF2BP1	chr17	47132731	-	IGF2BP1	chr17	47132793	+
75905	N/A	BI860748	IGF2BP1	chr17	47112155	+	SCAI	chr9	127750241	+
100498	THCA	TCGA-EM-A2CM	KAT7	chr17	47886570	+	IGF2BP1	chr17	47076470	+
100498	THCA	TCGA-EM-A2CM-01A	KAT7	chr17	47886570	+	IGF2BP1	chr17	47076471	+
100498	N/A	BF816639	NCL	chr2	232324973	+	IGF2BP1	chr17	47132662	+
100498	BRCA	TCGA-A8-A09Q-01A	PEMT	chr17	17480234	-	IGF2BP1	chr17	47118740	+
100498	BRCA	TCGA-AC-A6IV-01A	PRKCA	chr17	64302245	+	IGF2BP1	chr17	47126714	+
100498	BRCA	TCGA-A8-A09Q	RAI1	chr17	17627473	+	IGF2BP1	chr17	47076470	+
100498	BRCA	TCGA-A8-A09Q-01A	RAI1	chr17	17627473	+	IGF2BP1	chr17	47076471	+
100498	BRCA	TCGA-A8-A09Q-01A	RAI1	chr17	17627473	+	IGF2BP1	chr17	47102980	+
100502	BRCA	TCGA-A8-A09A-01A	ZBTB8OS	chr1	33093109	-	IGF2BP1	chr17	47109272	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	IGF2BP1	0.0121376998711203	0.34
KIRC	IGF2BP1	0.0129575666042593	0.35
KIRP	IGF2BP1	0.0172520396652374	0.45
DLBC	IGF2BP1	0.0198552440934227	0.5
SKCM	IGF2BP1	0.0257854615581754	0.62
SARC	IGF2BP1	0.0354552688954363	0.82

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	IGF2BP1	0.0232973550617699	0.7
LUSC	IGF2BP1	0.0439421651993956	1
THCA	IGF2BP1	0.00990543791507673	0.32
LGG	IGF2BP1	0.0413049647810115	1
OV	IGF2BP1	0.000786592586999564	0.026
ESCA	IGF2BP1	0.0337071711586922	0.98
SARC	IGF2BP1	0.0171247580050348	0.53

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C2239176	Liver carcinoma	1	CTD_human