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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL3 (NCBI Gene ID:11222)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL3
	Gene ID: 11222
	Gene Symbol	MRPL3
	Gene ID	11222
	Gene Name	mitochondrial ribosomal protein L3
	Synonyms	COXPD9\|MRL3\|RPML3
	Cytomap	3q22.1
	Type of Gene	protein-coding
	Description	39S ribosomal protein L3, mitochondrialL3mtMRP-L3mitochondrial 60S ribosomal protein L3mitochondrial large ribosomal subunit protein uL3m
	Modification date	20200313
	UniProtAcc	P09001

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL3	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPL3[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL3	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000264995	131206523	131206584	Frame-shift
ENST00000264995	131217022	131217121	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000264995	131217022	131217121	1723	518	616	348	123	156

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P09001	123	156	41	348	Chain	ID=PRO_0000077253;Note=39S ribosomal protein L3%2C mitochondrial
P09001	123	156	116	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
P09001	123	156	126	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
P09001	123	156	135	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
P09001	123	156	140	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
P09001	123	156	154	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
CHOL	MRPL3	-2.68429255990621	0.00390625
ESCA	MRPL3	-4.97897094908275	0.0048828125
KIRC	MRPL3	1.69955762234244	1.97132191719422e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
SARC	MRPL3	0.260025303	0.02362424
KIRP	MRPL3	-0.040673569	0.02443645

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Cell metabolism gene	MRPL3	UMPS	0.814789115	2.06E-79
COAD	Epifactor	MRPL3	RUVBL1	0.806608992	1.17E-76
COAD	Epifactor	MRPL3	ACTL6A	0.844970626	6.90E-91
ESCA	Epifactor	MRPL3	RUVBL1	0.814082458	1.15E-47
GBM	Cell metabolism gene	MRPL3	SRPRB	0.810555425	2.38E-41
KICH	Cell metabolism gene	MRPL3	GMPS	0.808164818	3.58E-22
KICH	CGC	MRPL3	GMPS	0.808164818	3.58E-22
KICH	CGC	MRPL3	TFG	0.850967353	1.27E-26
LUSC	Cell metabolism gene	MRPL3	UMPS	0.825126706	9.35E-139
LUSC	Epifactor	MRPL3	RUVBL1	0.819315721	3.19E-135
PCPG	CGC	MRPL3	TFG	0.815913571	6.85E-46
READ	Epifactor	MRPL3	ACTL6A	0.817685221	1.89E-26
UVM	Cell metabolism gene	MRPL3	TOMM70A	0.83092635	1.48E-21
UVM	Epifactor	MRPL3	MINA	0.817077245	2.42E-20
UVM	Epifactor	MRPL3	ACTL6A	0.883462019	2.10E-27
UVM	TSG	MRPL3	SHQ1	0.829726006	1.91E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	MRPL3	MRPL15	-2.15546608137429	0.000334546435624361
KIRC	MRPL3	MRPL11	-1.04966837625557	0.000354478033746394
LIHC	MRPL3	MRPL13	1.54402472107614	0.000655351190157038
KIRC	MRPL3	MRPL46	-7.36081421944909	0.0011460554764592
KIRP	MRPL3	MRPL46	-7.17671685013906	0.00123529229313135
BLCA	MRPL3	MRPL27	-4.19270554058168	0.00202178955078125
CHOL	MRPL3	MRPL46	-2.73791743817321	0.00390625
PRAD	MRPL3	MRPS9	1.04379115553269	0.00496210155254694
COAD	MRPL3	MRPL15	1.17181689924568	0.00513318181037904
ESCA	MRPL3	MRPL13	-1.07746088474995	0.0068359375
KICH	MRPL3	MRPL43	-2.18179102009894	0.00963503122329712
ESCA	MRPL3	MRPL17	-1.18756178214998	0.009765625
LIHC	MRPL3	MRPL17	-1.06225729770915	0.0124123499319886
STAD	MRPL3	MRPL4	1.4393539135682	0.0279771662317216
PRAD	MRPL3	MRPL11	1.12581653394628	1.15996224044503e-05
BRCA	MRPL3	MRPL27	-1.5584165725499	1.16393956539382e-08
KICH	MRPL3	MRPL15	1.54522142310359	1.19209289550781e-07
LUSC	MRPL3	MRPL21	-4.98277643789037	1.45947399043856e-08
STAD	MRPL3	MRPL17	-3.90880705449186	1.49570405483246e-06
LUSC	MRPL3	MRPS9	-3.60637641031661	1.82498668910368e-07
LUSC	MRPL3	MRPL15	-4.43702988385305	1.91594862886626e-08
LUAD	MRPL3	MRPS9	-1.32894454884901	1.98978698949574e-05
COAD	MRPL3	MRPL4	2.77705897514473	2.98023223876954e-07
LUAD	MRPL3	MRPL27	-1.39404329671842	3.44055922076328e-05
LUSC	MRPL3	MRPL27	-1.81809468729316	3.90393047420304e-06
BRCA	MRPL3	MRPL15	-3.82448964360727	5.49451113259074e-14
LUAD	MRPL3	MRPL21	-1.86897497221853	6.16191557420719e-07
LUSC	MRPL3	MRPL17	-6.83409683292749	6.93230040561614e-07
BRCA	MRPL3	MRPL21	-1.5345447607194	7.40794680786486e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL3

ICT1, CAND1, APP, MRPL9, MRPL4, MRPL12, MRPS9, MRPL39, MRPL23, MRPL13, MRPL17, MRPL10, MRPL46, MRPL42, MRPL55, MRPL52, MRPL19, MRPL41, RPS18, RPS15, NDUFS3, C1QBP, pth4, MRPS27, MRPL28, RPS8, HNRNPA1, MRPL37, MRPS30, MRPL47, NTRK1, MRPL15, MRPL18, RPS3, MRPL38, RPS14, RPS5, TUFM, CENPA, SCAF11, TIMM13, MRPL50, MRPL1, NAF1, Bach1, Nfya, Mad2l1, Vps28, Gpsm1, Ccdc12, Gbf1, Topbp1, FOXB1, FOXL2, FOXS1, RPL18, PPAN, MRPL35, CYLD, TRIM25, MINOS1-NBL1, RIOK1, LARP7, RECQL4, MRM1, HSPD1, PDK1, TRMT61B, AURKAIP1, RC3H1, ALYREF, SNRNP70, NFX1, PLEKHA4, PXN, EMC2, M, ERCC6, HSCB, ZC3HAV1, PRRC2A, KIF20A, ACAD9, AUH, C12orf65, C17orf80, C21orf33, C6orf203, CHCHD1, CS, FASTKD2, GFM1, GRSF1, HINT2, LONP1, LRPPRC, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, RPUSD4, SSBP1, TACO1, TBRG4, TEFM, TMEM70, TRUB2, TSFM, VWA8, EXD2, NOC2L, HIST1H1T, CIAO1, RBMS2, YBX1, FAM120A, MRPL30, H1FNT, LIN28A, RPL37, YBX2, MALSU1, RPL32, SRSF3, MRPL53, MRPL2, HNRNPU, ZC3H3, RPL13, RPL19, PRR3, ZNF346, HIST1H2AM, RPL36AL, RPL10, RPL17, SRSF7, FAHD1, MRPL27, MRPL51, APOBEC3D, RBM47, RPL13A, GADD45GIP1, ABT1, RPL35, WIPI1, NBR1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MRPL3	chr3	131181481	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
MRPL3	chr3	131181581	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL3	chr3	131181629	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL3	chr3	131181633	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL3	chr3	131181660	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL3	chr3	131181664	G	C	single_nucleotide_variant	Likely_pathogenic	Combined_oxidative_phosphorylation_deficiency_9\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL3	chr3	131181669	T	C	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL3	chr3	131181683	C	T	single_nucleotide_variant	Benign/Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL3	chr3	131186893	CA	C	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131186907	GA	G	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131186928	T	C	single_nucleotide_variant	Likely_benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131186943	A	G	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL3	chr3	131186944	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL3	chr3	131186945	C	G	single_nucleotide_variant	not_provided	Combined_oxidative_phosphorylation_deficiency_9	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL3	chr3	131186967	A	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_9	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL3	chr3	131188258	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131188318	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131188377	T	TAC	Microsatellite	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131188377	TAC	T	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131188528	T	G	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131188574	A	G	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL3	chr3	131188624	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131189748	A	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131189947	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131189972	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131190046	G	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL3	chr3	131190138	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131190425	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131206292	T	TA	Duplication	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131206292	TA	T	Deletion	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131206523	C	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
MRPL3	chr3	131206542	A	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL3	chr3	131206582	T	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL3	chr3	131208593	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131208683	AC	A	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131208859	G	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL3	chr3	131217196	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131217208	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131217318	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131219036	TAAA	T	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131219070	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131219082	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131219126	A	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131219286	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL3	chr3	131219293	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL3	chr3	131220121	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131220124	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131220228	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131220253	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131220357	C	T	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131220371	T	G	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131220428	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL3	chr3	131220457	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL3	chr3	131220550	G	A	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL3	chr3	131220644	A	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131220792	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131220820	A	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131221280	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL3	chr3	131221616	CG	C	Deletion	Pathogenic	Combined_oxidative_phosphorylation_deficiency_9	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
MRPL3	chr3	131221790	A	AACGGCCG	Insertion	Likely_benign	not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL3	LIHC	chr3	131208896	131208896	C	T	Missense_Mutation	p.R166Q	4
MRPL3	STAD	chr3	131217124	131217124	A	-	Splice_Site	.	3
MRPL3	ESCA	chr3	131188618	131188618	C	A	Splice_Site		3
MRPL3	BLCA	chr3	131220433	131220433	T	C	Silent	p.L73L	3
MRPL3	ESCA	chr3	131181670	131181670	G	T	Missense_Mutation	p.P315Q	3
MRPL3	STAD	chr3	131208833	131208833	A	T	Missense_Mutation	p.I187N	2
MRPL3	ESCA	chr3	131181670	131181670	G	T	Missense_Mutation		2
MRPL3	STAD	chr3	131220467	131220467	T	A	Missense_Mutation	p.K62M	2
MRPL3	LUAD	chr3	131181700	131181700	G	A	Missense_Mutation	p.P305L	2
MRPL3	STAD	chr3	131181615	131181615	A	G	Silent	p.Y333Y	2
MRPL3	COAD	chr3	131217025	131217025	G	A	Missense_Mutation	p.R156C	2
MRPL3	LUAD	chr3	131208896	131208896	C	A	Missense_Mutation	p.R166L	2
MRPL3	BLCA	chr3	131217033	131217033	G	A	Missense_Mutation	p.S153L	2
MRPL3	STAD	chr3	131217124	131217124	A	-	Splice_Site	p.V151_splice	2
MRPL3	UCEC	chr3	131181684	131181684	G	A	Silent	p.R325W	2
MRPL3	BLCA	chr3	131190094	131190094	T	C	Missense_Mutation	p.K220R	2
MRPL3	UCEC	chr3	131208901	131208901	A	C	Missense_Mutation	p.F164L	2
MRPL3	BLCA	chr3	131208827	131208827	G	T	Missense_Mutation	p.P189Q	2
MRPL3	LIHC	chr3	131188575	131188575	T	-	Frame_Shift_Del	p.M261fs	2
MRPL3	SKCM	chr3	131219361	131219361	G	A	Silent	p.S94S	2
MRPL3	UCEC	chr3	131217093	131217093	G	A	Missense_Mutation	p.T133M	2
MRPL3	LIHC	chr3	131181676	131181676	T	-	Frame_Shift_Del	p.N313fs	2
MRPL3	ACC	chr3	131219274	131219274	C	T	Silent	p.Q123Q	2
MRPL3	HNSC	chr3	131190031	131190031	C	A	Missense_Mutation	p.G241V	2
MRPL3	UCEC	chr3	131220529	131220529	A	G	Silent	p.S56P	2
MRPL3	BRCA	chr3	131188558	131188558	C	T	Missense_Mutation	p.D281N	2
MRPL3	STAD	chr3	131188567	131188567	G	A	Silent		2
MRPL3	THYM	chr3	131181588	131181588	C	T	Silent		2
MRPL3	UCEC	chr3	131220560	131220560	C	A	Splice_Site	e2-1	2
MRPL3	STAD	chr3	131188567	131188567	G	A	Silent	p.N263N	2
MRPL3	CESC	chr3	131220486	131220486	C	G	Missense_Mutation	p.E56Q	2
MRPL3	ESCA	chr3	131217123	131217124	-	A	Splice_Site	e4-2	1
MRPL3	PRAD	chr3	131186992	131186992	C	T	Silent	p.K279K	1
MRPL3	BLCA	chr3	131217033	131217033	G	A	Missense_Mutation		1
MRPL3	KIRP	chr3	131190046	131190046	G	T	Missense_Mutation		1
MRPL3	THYM	chr3	131219341	131219341	G	T	Missense_Mutation	p.A101D	1
MRPL3	COAD	chr3	131181683	131181683	C	T	Missense_Mutation	p.G311S	1
MRPL3	LUAD	chr3	131221616	131221616	C	A	Missense_Mutation	p.R17L	1
MRPL3	PRAD	chr3	131220553	131220553	G	A	Silent	p.H33H	1
MRPL3	BLCA	chr3	131208827	131208827	G	T	Missense_Mutation		1
MRPL3	LGG	chr3	131190117	131190117	A	C	Silent	p.G212G	1
MRPL3	THYM	chr3	131181588	131181588	C	T	Silent	p.A342A	1
MRPL3	COAD	chr3	131206525	131206525	T	-	Frame_Shift_Del	p.T210fs	1
MRPL3	LUAD	chr3	131221617	131221617	G	A	Nonsense_Mutation	p.R17*	1
MRPL3	READ	chr3	131217099	131217099	T	G	Missense_Mutation	p.K131T	1
MRPL3	BLCA	chr3	131220433	131220433	T	C	Silent		1
MRPL3	LGG	chr3	131190117	131190117	A	C	Silent		1
MRPL3	UCEC	chr3	131217093	131217093	G	A	Missense_Mutation	p.T160M	1
MRPL3	COAD	chr3	131208880	131208880	C	T	Silent	p.P171P	1
MRPL3	ESCA	chr3	131188618	131188618	C	A	Splice_Site	.	1
MRPL3	SARC	chr3	131220455	131220455	G	T	Missense_Mutation		1
MRPL3	BLCA	chr3	131217058	131217058	G	C	Missense_Mutation	p.L145V	1
MRPL3	LIHC	chr3	131208896	131208896	C	T	Missense_Mutation		1
MRPL3	UCEC	chr3	131208881	131208881	G	A	Missense_Mutation	p.P198L	1
MRPL3	GBM	chr3	131190114	131190114	T	C	Silent	p.K240K	1
MRPL3	SARC	chr3	131208920	131208920	G	T	Missense_Mutation		1
MRPL3	STAD	chr3	131206557	131206557	C	T	Missense_Mutation	p.R199H	1
MRPL3	LIHC	chr3	131206553	131206553	T	C	Silent		1
MRPL3	UCEC	chr3	131217123	131217124	-	A	Splice_Site	p.V151_splice	1
MRPL3	COAD	chr3	131217092	131217092	C	A	Silent	p.T133T	1
MRPL3	LUAD	chr3	131206585	131206585	C	T	Splice_Site		1
MRPL3	GBM	chr3	131190114	131190114	T	C	Silent		1
MRPL3	SKCM	chr3	131190074	131190074	G	A	Nonsense_Mutation	p.Q227X	1
MRPL3	COAD	chr3	131217099	131217099	T	A	Missense_Mutation	p.K131I	1
MRPL3	LUSC	chr3	131220414	131220414	G	T	Missense_Mutation	p.L107M	1
MRPL3	HNSC	chr3	131190031	131190031	C	A	Missense_Mutation		1
MRPL3	TGCT	chr3	131220418	131220419	AC	-	Frame_Shift_Del		1
MRPL3	COAD	chr3	131221602	131221602	G	T	Missense_Mutation	p.L22M	1
MRPL3	LUSC	chr3	131208878	131208878	G	A	Missense_Mutation	p.P199L	1
MRPL3	HNSC	chr3	131219333	131219333	G	A	Silent	p.L104L	1
MRPL3	TGCT	chr3	131220418	131220419	AC	-	Frame_Shift_Del	p.78_79del	1
MRPL3	COAD	chr3	131217026	131217026	A	C	Missense_Mutation	p.F155L	1
MRPL3	LUSC	chr3	131181652	131181652	G	T	Missense_Mutation	p.P348H	1
MRPL3	SKCM	chr3	131190074	131190074	G	A	Nonsense_Mutation	p.Q227*	1
MRPL3	TGCT	chr3	131220418	131220419	AC	-	Frame_Shift_Del	p.C78fs	1
MRPL3	LIHC	chr3	131181654	131181654	A	-	Frame_Shift_Del	p.F320fs	1
MRPL3	OV	chr3	132664369	132664369	T	C	Missense_Mutation	p.K312R	1
MRPL3	ACC	chr3	131219274	131219274	C	T	Splice_Site	p.Q123_splice	1
MRPL3	KIRP	chr3	131188617	131188617	C	T	Missense_Mutation	p.D247N	1
MRPL3	CESC	chr3	131220486	131220486	C	G	Missense_Mutation		1
MRPL3	LIHC	chr3	131188568	131188568	T	-	Frame_Shift_Del	p.N263fs	1
MRPL3	ESCA	chr3	131188618	131188618	C	A	Splice_Site	e8-1	1
MRPL3	PAAD	chr3	131219286	131219286	G	T	Silent	p.V119V	1
MRPL3	BLCA	chr3	131217058	131217058	G	C	Missense_Mutation		1
MRPL3	KIRP	chr3	131190046	131190046	G	T	Missense_Mutation	p.T263N	1
MRPL3	THYM	chr3	131190075	131190075	G	A	Silent	p.G226G	1
MRPL3	LUAD	chr3	131208916	131208916	T	A	Silent	p.T159T	1

Copy number variation (CNV) of MRPL3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
92412	PRAD	TCGA-G9-6364-01A	CPNE4	chr3	131753411	-	MRPL3	chr3	131219365	-
92412	PRAD	TCGA-HI-7171-01A	CPNE4	chr3	131753411	-	MRPL3	chr3	131220559	-
100350	STAD	TCGA-FP-8631-01A	MRPL3	chr3	131206524	-	CPNE4	chr3	131759165	-
90011	ESCA	TCGA-R6-A6Y2	MRPL3	chr3	131206523	-	TTLL11	chr9	124801647	-
92412	ACC	TCGA-OR-A5JF	PARL	chr3	183602509	-	MRPL3	chr3	131190123	-
92412	LUSC	TCGA-18-3421	RPS12	chr6	133135752	+	MRPL3	chr3	131190123	-
92413	STAD	TCGA-3M-AB47	TMPRSS4	chr11	117988169	+	MRPL3	chr3	131190123	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
KIRC	MRPL3	1.55443366214365	0.441111274883434	0.000129449956362615	0.000231513184661261	0.000141862328501181	604
KIRC	MRPL3	1.55443366214365	0.441111274883434	0.000129449956362615	0.000231513184661261	0.000141862328501181	604
PAAD	MRPL3	0.549962217294609	-0.597905698943271	0.000974671751062104	0.000798451036508865	0.000986678431894199	182
PAAD	MRPL3	0.549962217294609	-0.597905698943271	0.000974671751062104	0.000798451036508865	0.000986678431894199	182
UVM	MRPL3	4.36641619150237	1.47394257916916	0.00111209361974861	0.000492797009236859	0.00128225918204256	80
COAD	MRPL3	0.434531203983885	-0.83348752101209	0.00123634304342827	0.00121279755569414	0.00116944294022957	315
COAD	MRPL3	0.434531203983885	-0.83348752101209	0.00123634304342827	0.00121279755569414	0.00116944294022957	315
LUSC	MRPL3	0.684022172856273	-0.379764945428449	0.00284380572182949	0.00269484192272835	0.00282715997375438	545
UVM	MRPL3	4.61923782602555	1.53022971876241	0.00338299532206956	0.00332632496343027	0.00328585838368557	80
LGG	MRPL3	1.78857901327268	0.581421457255314	0.00339911060043227	0.00321637788210036	0.00339176639610178	525
BRCA	MRPL3	0.705036078642573	-0.349506302099747	0.00431277312407027	0.00377949859675957	0.00431002965233125	1200
SARC	MRPL3	0.535713916571634	-0.624154998139515	0.00463709605597528	0.00451766997405671	0.00484869415306779	265
SARC	MRPL3	1.49824941474165	0.404297369728117	0.00532009876393034	0.00625927890728453	0.00536372079303256	265
SARC	MRPL3	0.61152783371252	-0.491794807781184	0.00575385881119048	0.00531705359574612	0.00557868903067651	265
SKCM	MRPL3	1.36711912850074	0.312705699885379	0.00659686816069932	0.00687061905277741	0.0066696097680501	462
SKCM	MRPL3	1.36711912850074	0.312705699885379	0.00659686816069932	0.00687061905277741	0.0066696097680501	462
LIHC	MRPL3	1.4015780905139	0.337598809309762	0.0117596557353283	0.0112374129491856	0.0118000551090463	417
LIHC	MRPL3	1.4015780905139	0.337598809309762	0.0117596557353283	0.0112374129491856	0.0118000551090463	417
KIRP	MRPL3	0.452118233017778	-0.793811555882368	0.0126210840432792	0.016316109133562	0.013124548686759	320
KIRP	MRPL3	0.452118233017778	-0.793811555882368	0.0126210840432792	0.016316109133562	0.013124548686759	320
BLCA	MRPL3	1.36979167136105	0.314658663577059	0.0156301180581169	0.0169251962026673	0.0159507749230498	422
MESO	MRPL3	0.585639916851305	-0.53505015463606	0.0227186689226538	0.0217018217551997	0.0223001036019781	85
MESO	MRPL3	0.585639916851305	-0.53505015463606	0.0227186689226538	0.0217018217551997	0.0223001036019781	85
SKCM	MRPL3	0.76870881441787	-0.26304303603757	0.026183247629597	0.0275087237180524	0.0263025320833052	462
SKCM	MRPL3	0.76870881441787	-0.26304303603757	0.026183247629597	0.0275087237180524	0.0263025320833052	462
LAML	MRPL3	0.565367259520439	-0.57027974215481	0.0267014436721538	0.0286300021000068	0.026885403979315	160
PAAD	MRPL3	1.62186914010683	0.48357927432934	0.0303794270193965	0.0347794538928496	0.0309161287632971	182
PAAD	MRPL3	1.62186914010683	0.48357927432934	0.0303794270193965	0.0347794538928496	0.0309161287632971	182
OV	MRPL3	0.807987888367405	-0.213208210217689	0.0326926355165448	0.0301923478587003	0.0325927216264621	307
BLCA	MRPL3	0.718473148964019	-0.330626945123068	0.0346917607858932	0.0347396282929439	0.0346469688648799	422
OV	MRPL3	1.49341895813654	0.401068094152883	0.035379373773044	0.0343650481411385	0.0353217541627235	307
LUAD	MRPL3	1.30670038632256	0.267505170660399	0.0428732909230895	0.0460955778226912	0.0432787357611747	564
LUAD	MRPL3	1.30670038632256	0.267505170660399	0.0428732909230895	0.0460955778226912	0.0432787357611747	564
PCPG	MRPL3	9.14902365516335	2.21364716924038	0.0437181006826673	0.0344520532339992	0.0396039755319878	185
PCPG	MRPL3	9.14902365516335	2.21364716924038	0.0437181006826673	0.0344520532339992	0.0396039755319878	185
BRCA	MRPL3	0.768762659081015	-0.262972992899735	0.0491866228502864	0.043977017844386	0.0491610814552347	1200
LGG	MRPL3	2.74244344391354	1.00884929086292	1.7812846857289e-06	1.52149233267721e-06	2.11793859963795e-06	525
SKCM	MRPL3	1.57692629665382	0.45547757046121	2.28511481992798e-05	3.81389846511547e-05	2.28311358177727e-05	462
SKCM	MRPL3	1.57692629665382	0.45547757046121	2.28511481992798e-05	3.81389846511547e-05	2.28311358177727e-05	462
LGG	MRPL3	2.34409228178549	0.851898240302225	2.35880447372012e-05	6.90437788696931e-05	2.60174439424638e-05	525

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	MRPL3	0.000287118338575966	0.008
TGCT	MRPL3	0.00126095983361846	0.034
LUAD	MRPL3	0.0210544617961286	0.55

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MRPL3	0.0142505265414904	0.43
LGG	MRPL3	0.0348751961429709	1
LAML	MRPL3	0.0108473741624397	0.35
PAAD	MRPL3	0.0120914329694694	0.37
ESCA	MRPL3	0.000191990652315719	0.0063

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C3281234	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 9	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT