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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL35 (NCBI Gene ID:11224)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL35
	Gene ID: 11224
	Gene Symbol	RPL35
	Gene ID	11224
	Gene Name	ribosomal protein L35
	Synonyms	DBA19\|L35
	Cytomap	9q33.3
	Type of Gene	protein-coding
	Description	60S ribosomal protein L35large ribosomal subunit protein uL29
	Modification date	20200313
	UniProtAcc	P42766

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL35	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL35[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL35	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000348462	127622461	127622543	Frame-shift
ENST00000348462	127623697	127623834	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	RPL35	-1.06475238059392	2.72286325678163e-08
KIRP	RPL35	-1.52981101975496	9.0546440333128e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
UCS	RPL35	0.043252562	0.010179898
CESC	RPL35	-0.031389883	0.015152651
PRAD	RPL35	0.047945964	0.034204922
PCPG	RPL35	0.068428459	0.047274068

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL35 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
BRCA	Cell metabolism gene	RPL35	FAU	0.802055079	1.82E-274
CESC	Cell metabolism gene	RPL35	FAU	0.80477511	2.73E-71
CESC	Cell metabolism gene	RPL35	PSMB7	0.81848835	1.24E-75
CHOL	TF	RPL35	REXO4	0.83707159	7.81E-13
DLBC	Cell metabolism gene	RPL35	PGLS	0.800590584	8.48E-12
DLBC	Cell metabolism gene	RPL35	PSMC3	0.804316393	5.74E-12
DLBC	Cell metabolism gene	RPL35	DGUOK	0.805907078	4.85E-12
DLBC	Cell metabolism gene	RPL35	ITPA	0.808525733	3.65E-12
DLBC	Cell metabolism gene	RPL35	EXOSC4	0.810610949	2.91E-12
DLBC	Cell metabolism gene	RPL35	POLR2J	0.815304074	1.72E-12
DLBC	Cell metabolism gene	RPL35	HSD17B10	0.822794134	7.26E-13
DLBC	Cell metabolism gene	RPL35	TIMM50	0.823276851	6.85E-13
DLBC	Cell metabolism gene	RPL35	PTDSS2	0.825663494	5.15E-13
DLBC	Cell metabolism gene	RPL35	SNRPD3	0.829398739	3.27E-13
DLBC	Cell metabolism gene	RPL35	TIMM9	0.837489495	1.17E-13
DLBC	Cell metabolism gene	RPL35	POLR2I	0.840015463	8.41E-14
DLBC	Cell metabolism gene	RPL35	PSMD13	0.841090541	7.29E-14
DLBC	Cell metabolism gene	RPL35	POLR2L	0.842528242	6.01E-14
DLBC	Cell metabolism gene	RPL35	DPM2	0.842682388	5.89E-14
DLBC	Cell metabolism gene	RPL35	PMPCA	0.843379319	5.36E-14
DLBC	Cell metabolism gene	RPL35	PSMB7	0.845904425	3.80E-14
DLBC	Cell metabolism gene	RPL35	GFER	0.846915825	3.30E-14
DLBC	Cell metabolism gene	RPL35	GEMIN7	0.849184206	2.40E-14
DLBC	Cell metabolism gene	RPL35	MED27	0.84984166	2.19E-14
DLBC	Cell metabolism gene	RPL35	PFDN4	0.857606528	7.05E-15
DLBC	Cell metabolism gene	RPL35	TIMM13	0.86130461	4.01E-15
DLBC	Cell metabolism gene	RPL35	PSMB3	0.861519299	3.88E-15
DLBC	Cell metabolism gene	RPL35	POLR2F	0.862667565	3.24E-15
DLBC	Cell metabolism gene	RPL35	PSMC5	0.864969862	2.26E-15
DLBC	Cell metabolism gene	RPL35	PFDN5	0.873681176	5.37E-16
DLBC	Cell metabolism gene	RPL35	TOMM22	0.875205979	4.13E-16
DLBC	Cell metabolism gene	RPL35	FAU	0.879208089	2.04E-16
DLBC	Cell metabolism gene	RPL35	NME2	0.89691721	6.48E-18
DLBC	Cell metabolism gene	RPL35	SNRPD2	0.919799286	2.59E-20
DLBC	CGC	RPL35	U2AF1	0.802221153	7.16E-12
DLBC	CGC	RPL35	NTHL1	0.802757922	6.77E-12
DLBC	CGC	RPL35	HRAS	0.827655613	4.05E-13
DLBC	CGC	RPL35	NACA	0.833380415	1.99E-13
DLBC	Epifactor	RPL35	PRPF31	0.805769841	4.92E-12
DLBC	Epifactor	RPL35	RBX1	0.807420762	4.12E-12
DLBC	Epifactor	RPL35	EXOSC4	0.810610949	2.91E-12
DLBC	Epifactor	RPL35	MBD3	0.811063812	2.77E-12
DLBC	Epifactor	RPL35	PPP4C	0.819158244	1.11E-12
DLBC	Epifactor	RPL35	TAF10	0.82427444	6.08E-13
DLBC	Epifactor	RPL35	DMAP1	0.82695795	4.40E-13
DLBC	Epifactor	RPL35	FBL	0.852429452	1.51E-14
DLBC	IUPHAR	RPL35	SLC25A39	0.804362956	5.71E-12
DLBC	IUPHAR	RPL35	SLC25A26	0.808394007	3.71E-12
DLBC	IUPHAR	RPL35	HRAS	0.827655613	4.05E-13
DLBC	IUPHAR	RPL35	MFSD2B	0.843761875	5.09E-14
DLBC	TF	RPL35	MBD3	0.811063812	2.77E-12
DLBC	TF	RPL35	THAP7	0.822074726	7.90E-13
DLBC	TF	RPL35	ZNF444	0.822418932	7.58E-13
DLBC	TF	RPL35	THAP3	0.833973303	1.84E-13
DLBC	TF	RPL35	THAP4	0.841984109	6.47E-14
DLBC	TF	RPL35	REXO4	0.870590835	9.04E-16
DLBC	TF	RPL35	NME2	0.89691721	6.48E-18
DLBC	TSG	RPL35	PHB	0.800413457	8.64E-12
DLBC	TSG	RPL35	TSSC4	0.831963707	2.37E-13
DLBC	TSG	RPL35	PARK7	0.861945458	3.63E-15
DLBC	TSG	RPL35	GNB2L1	0.879537982	1.92E-16
DLBC	TSG	RPL35	GADD45GIP1	0.908070283	5.26E-19
GBM	Cell metabolism gene	RPL35	CCT4	0.810331302	2.60E-41
GBM	Cell metabolism gene	RPL35	SNRPG	0.81850556	8.93E-43
GBM	Cell metabolism gene	RPL35	FAU	0.821750335	2.23E-43
HNSC	Cell metabolism gene	RPL35	PSMB7	0.804620423	8.89E-130
KICH	Cell metabolism gene	RPL35	SEC61B	0.817692132	4.63E-23
KICH	Cell metabolism gene	RPL35	SNRPD2	0.849865507	1.72E-26
KIRP	Cell metabolism gene	RPL35	PGLS	0.811040181	9.85E-77
KIRP	Cell metabolism gene	RPL35	PFDN5	0.821463823	2.71E-80
KIRP	Cell metabolism gene	RPL35	POLR2I	0.830168596	1.89E-83
KIRP	Cell metabolism gene	RPL35	SNRPD2	0.869049317	3.98E-100
KIRP	Cell metabolism gene	RPL35	FAU	0.905872459	8.46E-122
KIRP	Epifactor	RPL35	TAF10	0.828616168	7.12E-83
KIRP	TSG	RPL35	GADD45GIP1	0.862198715	7.97E-97
LAML	Cell metabolism gene	RPL35	SNRPD2	0.84209877	1.01E-47
LAML	Epifactor	RPL35	FBL	0.812451595	6.41E-42
LGG	Cell metabolism gene	RPL35	FAU	0.819319224	1.17E-129
LIHC	Cell metabolism gene	RPL35	PFDN5	0.804037592	4.22E-97
LUAD	Cell metabolism gene	RPL35	FAU	0.824094993	8.34E-144
PAAD	Cell metabolism gene	RPL35	FAU	0.831458567	4.48E-48
PCPG	Cell metabolism gene	RPL35	PFDN5	0.813729037	1.83E-45
PCPG	Cell metabolism gene	RPL35	FAU	0.834583475	8.73E-50
PCPG	IUPHAR	RPL35	CSNK2B	0.818794567	1.84E-46
PCPG	TF	RPL35	ZNF358	0.803372347	1.63E-43
PRAD	Cell metabolism gene	RPL35	GFER	0.800896518	3.80E-124
PRAD	Cell metabolism gene	RPL35	NME2	0.803880885	9.51E-126
PRAD	Cell metabolism gene	RPL35	ZNRD1	0.803905911	9.22E-126
PRAD	Cell metabolism gene	RPL35	PGLS	0.808545912	2.62E-128
PRAD	Cell metabolism gene	RPL35	TOMM7	0.824854518	7.65E-138
PRAD	Cell metabolism gene	RPL35	PFDN5	0.832505714	1.15E-142
PRAD	Cell metabolism gene	RPL35	POLR2F	0.852588186	1.41E-156
PRAD	Cell metabolism gene	RPL35	POLR2I	0.860219593	2.04E-162
PRAD	Cell metabolism gene	RPL35	PSMB7	0.879167099	1.49E-178
PRAD	Cell metabolism gene	RPL35	SNRPD2	0.900062992	7.68E-200
PRAD	Cell metabolism gene	RPL35	FAU	0.91516105	2.14E-218
PRAD	CGC	RPL35	NACA	0.813618372	3.58E-131
PRAD	Epifactor	RPL35	FBL	0.857370597	3.39E-160
PRAD	TF	RPL35	NME2	0.803880885	9.51E-126
PRAD	TF	RPL35	THAP3	0.804033904	7.86E-126
PRAD	TF	RPL35	ZNF524	0.819533754	1.26E-134
PRAD	TSG	RPL35	GADD45GIP1	0.825710478	2.27E-138
PRAD	TSG	RPL35	GNB2L1	0.826328576	9.40E-139
READ	Cell metabolism gene	RPL35	PSMB7	0.840965635	3.12E-29
THCA	Cell metabolism gene	RPL35	DPM3	0.815569224	1.56E-137
THCA	Cell metabolism gene	RPL35	PSMB7	0.818620154	2.16E-139
THCA	Cell metabolism gene	RPL35	POLR2I	0.834162625	1.96E-149
THCA	Cell metabolism gene	RPL35	DGUOK	0.838416344	2.29E-152
THCA	Cell metabolism gene	RPL35	PFDN5	0.877773089	2.58E-184
THCA	Cell metabolism gene	RPL35	SNRPD2	0.891704227	2.19E-198
THCA	Cell metabolism gene	RPL35	FAU	0.924508578	6.16E-241
THCA	Epifactor	RPL35	TAF10	0.832867355	1.47E-148
THCA	IUPHAR	RPL35	CSNK2B	0.808258327	3.23E-133
THCA	TF	RPL35	ZNF524	0.812186304	1.64E-135
THCA	TSG	RPL35	AIP	0.838419137	2.28E-152
THCA	TSG	RPL35	GADD45GIP1	0.84270063	2.09E-155
THYM	Cell metabolism gene	RPL35	MPST	0.800908399	1.69E-28
THYM	Cell metabolism gene	RPL35	UROS	0.805271131	5.15E-29
THYM	Cell metabolism gene	RPL35	MMAB	0.805975595	4.24E-29
THYM	Cell metabolism gene	RPL35	LSM2	0.806631908	3.53E-29
THYM	Cell metabolism gene	RPL35	LCMT1	0.806756907	3.41E-29
THYM	Cell metabolism gene	RPL35	SMPD2	0.806963441	3.22E-29
THYM	Cell metabolism gene	RPL35	TOMM7	0.807404493	2.85E-29
THYM	Cell metabolism gene	RPL35	TBCB	0.80848119	2.11E-29
THYM	Cell metabolism gene	RPL35	PCYT2	0.809332355	1.66E-29
THYM	Cell metabolism gene	RPL35	TAZ	0.809340796	1.65E-29
THYM	Cell metabolism gene	RPL35	OAZ1	0.812610652	6.50E-30
THYM	Cell metabolism gene	RPL35	PSMB1	0.812693545	6.34E-30
THYM	Cell metabolism gene	RPL35	SEC61G	0.814105725	4.21E-30
THYM	Cell metabolism gene	RPL35	TOMM22	0.814140598	4.17E-30
THYM	Cell metabolism gene	RPL35	ATP5G1	0.818037373	1.32E-30
THYM	Cell metabolism gene	RPL35	HSD17B10	0.820036347	7.27E-31
THYM	Cell metabolism gene	RPL35	PSMB10	0.820749799	5.86E-31
THYM	Cell metabolism gene	RPL35	POLD2	0.823979682	2.18E-31
THYM	Cell metabolism gene	RPL35	ALG3	0.824530985	1.84E-31
THYM	Cell metabolism gene	RPL35	PGP	0.82595541	1.18E-31
THYM	Cell metabolism gene	RPL35	LSM4	0.826517779	9.89E-32
THYM	Cell metabolism gene	RPL35	TIMM17B	0.82814143	5.92E-32
THYM	Cell metabolism gene	RPL35	SSR4	0.828145207	5.92E-32
THYM	Cell metabolism gene	RPL35	GFER	0.82841963	5.42E-32
THYM	Cell metabolism gene	RPL35	POLE4	0.828933013	4.60E-32
THYM	Cell metabolism gene	RPL35	DGUOK	0.829454042	3.90E-32
THYM	Cell metabolism gene	RPL35	PPCDC	0.82976294	3.53E-32
THYM	Cell metabolism gene	RPL35	SNRPD3	0.829795665	3.49E-32
THYM	Cell metabolism gene	RPL35	PSMD13	0.831255844	2.18E-32
THYM	Cell metabolism gene	RPL35	SRM	0.831981804	1.72E-32
THYM	Cell metabolism gene	RPL35	FPGS	0.832730759	1.35E-32
THYM	Cell metabolism gene	RPL35	POLD4	0.834349584	7.93E-33
THYM	Cell metabolism gene	RPL35	PSMC1	0.836814919	3.48E-33
THYM	Cell metabolism gene	RPL35	PSMC5	0.837322847	2.94E-33
THYM	Cell metabolism gene	RPL35	TOMM40	0.838431849	2.02E-33
THYM	Cell metabolism gene	RPL35	PSME2	0.839487098	1.41E-33
THYM	Cell metabolism gene	RPL35	MIF	0.841520647	6.98E-34
THYM	Cell metabolism gene	RPL35	HMBS	0.848105493	6.73E-35
THYM	Cell metabolism gene	RPL35	GEMIN7	0.848650419	5.51E-35
THYM	Cell metabolism gene	RPL35	GEMIN6	0.849085637	4.70E-35
THYM	Cell metabolism gene	RPL35	PSMC3	0.851250071	2.12E-35
THYM	Cell metabolism gene	RPL35	PHPT1	0.852900092	1.14E-35
THYM	Cell metabolism gene	RPL35	PHKG2	0.853693694	8.45E-36
THYM	Cell metabolism gene	RPL35	EXOSC5	0.855715369	3.91E-36
THYM	Cell metabolism gene	RPL35	IDH3G	0.855979602	3.53E-36
THYM	Cell metabolism gene	RPL35	MVD	0.856264554	3.16E-36
THYM	Cell metabolism gene	RPL35	PSMD4	0.85656458	2.81E-36
THYM	Cell metabolism gene	RPL35	GMPPA	0.85845236	1.35E-36
THYM	Cell metabolism gene	RPL35	NANS	0.858665718	1.24E-36
THYM	Cell metabolism gene	RPL35	PTGES2	0.860503309	5.99E-37
THYM	Cell metabolism gene	RPL35	TIMM10	0.863840491	1.55E-37
THYM	Cell metabolism gene	RPL35	POLR2F	0.865779636	6.98E-38
THYM	Cell metabolism gene	RPL35	PMPCA	0.869472436	1.47E-38
THYM	Cell metabolism gene	RPL35	WBSCR22	0.869502167	1.45E-38
THYM	Cell metabolism gene	RPL35	MTX1	0.870287862	1.03E-38
THYM	Cell metabolism gene	RPL35	ITPA	0.871268126	6.75E-39
THYM	Cell metabolism gene	RPL35	GUK1	0.87158347	5.89E-39
THYM	Cell metabolism gene	RPL35	SSR2	0.872096267	4.70E-39
THYM	Cell metabolism gene	RPL35	EBP	0.872643011	3.70E-39
THYM	Cell metabolism gene	RPL35	EXOSC4	0.883024113	3.10E-41
THYM	Cell metabolism gene	RPL35	APRT	0.888459938	2.11E-42
THYM	Cell metabolism gene	RPL35	SLC27A5	0.892464101	2.66E-43
THYM	Cell metabolism gene	RPL35	POLR2J	0.89569535	4.71E-44
THYM	Cell metabolism gene	RPL35	ACOT8	0.895960259	4.07E-44
THYM	Cell metabolism gene	RPL35	POLR2H	0.896186293	3.60E-44
THYM	Cell metabolism gene	RPL35	PSMB3	0.902070284	1.30E-45
THYM	Cell metabolism gene	RPL35	PSMB7	0.904810574	2.57E-46
THYM	Cell metabolism gene	RPL35	TIMM13	0.905767546	1.45E-46
THYM	Cell metabolism gene	RPL35	POLR2I	0.906432054	9.64E-47
THYM	Cell metabolism gene	RPL35	DPM3	0.909467891	1.46E-47
THYM	Cell metabolism gene	RPL35	TIMM50	0.910438323	7.88E-48
THYM	Cell metabolism gene	RPL35	PGLS	0.91080607	6.23E-48
THYM	Cell metabolism gene	RPL35	TIMM8B	0.915492382	2.82E-49
THYM	Cell metabolism gene	RPL35	PFDN5	0.916029486	1.95E-49
THYM	Cell metabolism gene	RPL35	DPM2	0.916402705	1.51E-49
THYM	Cell metabolism gene	RPL35	SNRPD2	0.917925221	5.25E-50
THYM	Cell metabolism gene	RPL35	FAU	0.943704578	1.71E-59
THYM	CGC	RPL35	MGMT	0.827313927	7.70E-32
THYM	CGC	RPL35	ASPSCR1	0.835693808	5.07E-33
THYM	CGC	RPL35	SDHAF2	0.843303676	3.74E-34
THYM	CGC	RPL35	TFPT	0.854171657	7.05E-36
THYM	CGC	RPL35	RBM10	0.871135315	7.15E-39
THYM	Epifactor	RPL35	PELP1	0.801213714	1.56E-28
THYM	Epifactor	RPL35	PRMT1	0.807649379	2.66E-29
THYM	Epifactor	RPL35	DMAP1	0.81302448	5.77E-30
THYM	Epifactor	RPL35	ZGPAT	0.818465613	1.17E-30
THYM	Epifactor	RPL35	RRP8	0.827483843	7.30E-32
THYM	Epifactor	RPL35	RUVBL2	0.832442325	1.48E-32
THYM	Epifactor	RPL35	PPP4C	0.838622721	1.89E-33
THYM	Epifactor	RPL35	LAS1L	0.845041528	2.03E-34
THYM	Epifactor	RPL35	NOC2L	0.845855403	1.51E-34
THYM	Epifactor	RPL35	MBD3	0.849673291	3.79E-35
THYM	Epifactor	RPL35	TFPT	0.854171657	7.05E-36
THYM	Epifactor	RPL35	EXOSC5	0.855715369	3.91E-36
THYM	Epifactor	RPL35	C17orf49	0.863447702	1.82E-37
THYM	Epifactor	RPL35	CCDC101	0.868148613	2.58E-38
THYM	Epifactor	RPL35	EXOSC4	0.883024113	3.10E-41
THYM	Epifactor	RPL35	INO80E	0.886770243	4.94E-42
THYM	Epifactor	RPL35	FBL	0.890227537	8.54E-43
THYM	Epifactor	RPL35	PRPF31	0.894203123	1.05E-43
THYM	Epifactor	RPL35	TAF10	0.913929576	8.07E-49
THYM	Epifactor	RPL35	BRMS1	0.914225585	6.62E-49
THYM	Epifactor	RPL35	SIRT6	0.914787698	4.54E-49
THYM	Epifactor	RPL35	ZNHIT1	0.916246532	1.68E-49
THYM	IUPHAR	RPL35	MPST	0.800908399	1.69E-28
THYM	IUPHAR	RPL35	MAP3K11	0.803175448	9.16E-29
THYM	IUPHAR	RPL35	SMPD2	0.806963441	3.22E-29
THYM	IUPHAR	RPL35	PRMT1	0.807649379	2.66E-29
THYM	IUPHAR	RPL35	PPIA	0.809484004	1.59E-29
THYM	IUPHAR	RPL35	PSMB1	0.812693545	6.34E-30
THYM	IUPHAR	RPL35	EGLN2	0.814212106	4.09E-30
THYM	IUPHAR	RPL35	ATP6V0B	0.822258623	3.70E-31
THYM	IUPHAR	RPL35	SIRT3	0.848604774	5.61E-35
THYM	IUPHAR	RPL35	PHKG2	0.853693694	8.45E-36
THYM	IUPHAR	RPL35	MVD	0.856264554	3.16E-36
THYM	IUPHAR	RPL35	PTGES2	0.860503309	5.99E-37
THYM	IUPHAR	RPL35	SLC27A5	0.892464101	2.66E-43
THYM	IUPHAR	RPL35	SIRT6	0.914787698	4.54E-49
THYM	Kinase	RPL35	MAP3K11	0.803175448	9.16E-29
THYM	Kinase	RPL35	FASTK	0.811936585	7.89E-30
THYM	Kinase	RPL35	PHKG2	0.853693694	8.45E-36
THYM	TF	RPL35	RBCK1	0.808686045	1.99E-29
THYM	TF	RPL35	ZNF580	0.817032711	1.78E-30
THYM	TF	RPL35	ZGPAT	0.818465613	1.17E-30
THYM	TF	RPL35	DRAP1	0.820302287	6.71E-31
THYM	TF	RPL35	ZNF511	0.822280126	3.68E-31
THYM	TF	RPL35	USF1	0.826152805	1.11E-31
THYM	TF	RPL35	ZNF32	0.831924064	1.76E-32
THYM	TF	RPL35	REXO4	0.832536366	1.44E-32
THYM	TF	RPL35	IRF3	0.833982412	8.95E-33
THYM	TF	RPL35	GLI4	0.838399141	2.04E-33
THYM	TF	RPL35	ZNF428	0.841813339	6.31E-34
THYM	TF	RPL35	ZBTB48	0.842622629	4.75E-34
THYM	TF	RPL35	MBD3	0.849673291	3.79E-35
THYM	TF	RPL35	ETV2	0.850121169	3.21E-35
THYM	TF	RPL35	THAP3	0.859529119	8.82E-37
THYM	TF	RPL35	ZNF688	0.864922471	9.95E-38
THYM	TF	RPL35	ZNF581	0.870180229	1.08E-38
THYM	TF	RPL35	ZNF524	0.874022138	2.01E-39
THYM	TF	RPL35	THAP7	0.877893703	3.48E-40
THYM	TF	RPL35	ZNF787	0.885054534	1.15E-41
THYM	TSG	RPL35	STUB1	0.831161928	2.25E-32
THYM	TSG	RPL35	IRF3	0.833982412	8.95E-33
THYM	TSG	RPL35	PARK7	0.839281789	1.51E-33
THYM	TSG	RPL35	ZBTB48	0.842622629	4.75E-34
THYM	TSG	RPL35	ST20	0.843890204	3.05E-34
THYM	TSG	RPL35	GABARAP	0.846606408	1.16E-34
THYM	TSG	RPL35	SIRT3	0.848604774	5.61E-35
THYM	TSG	RPL35	GLTSCR2	0.850901801	2.41E-35
THYM	TSG	RPL35	GNB2L1	0.864600833	1.14E-37
THYM	TSG	RPL35	NPRL2	0.895159744	6.30E-44
THYM	TSG	RPL35	TSSC4	0.89702493	2.27E-44
THYM	TSG	RPL35	BRMS1	0.914225585	6.62E-49
THYM	TSG	RPL35	SIRT6	0.914787698	4.54E-49
THYM	TSG	RPL35	GADD45GIP1	0.924786938	3.43E-52
UCEC	Cell metabolism gene	RPL35	PSMB7	0.805624956	3.97E-47
UCEC	Cell metabolism gene	RPL35	PFDN5	0.817376091	1.51E-49
UCEC	Cell metabolism gene	RPL35	FAU	0.84540581	4.22E-56
UCS	Cell metabolism gene	RPL35	MPST	0.800908399	1.69E-28
UCS	Cell metabolism gene	RPL35	UROS	0.805271131	5.15E-29
UCS	Cell metabolism gene	RPL35	MMAB	0.805975595	4.24E-29
UCS	Cell metabolism gene	RPL35	LSM2	0.806631908	3.53E-29
UCS	Cell metabolism gene	RPL35	LCMT1	0.806756907	3.41E-29
UCS	Cell metabolism gene	RPL35	SMPD2	0.806963441	3.22E-29
UCS	Cell metabolism gene	RPL35	TOMM7	0.807404493	2.85E-29
UCS	Cell metabolism gene	RPL35	TBCB	0.80848119	2.11E-29
UCS	Cell metabolism gene	RPL35	PCYT2	0.809332355	1.66E-29
UCS	Cell metabolism gene	RPL35	TAZ	0.809340796	1.65E-29
UCS	Cell metabolism gene	RPL35	OAZ1	0.812610652	6.50E-30
UCS	Cell metabolism gene	RPL35	PSMB1	0.812693545	6.34E-30
UCS	Cell metabolism gene	RPL35	SEC61G	0.814105725	4.21E-30
UCS	Cell metabolism gene	RPL35	TOMM22	0.814140598	4.17E-30
UCS	Cell metabolism gene	RPL35	ATP5G1	0.818037373	1.32E-30
UCS	Cell metabolism gene	RPL35	HSD17B10	0.820036347	7.27E-31
UCS	Cell metabolism gene	RPL35	PSMB10	0.820749799	5.86E-31
UCS	Cell metabolism gene	RPL35	POLD2	0.823979682	2.18E-31
UCS	Cell metabolism gene	RPL35	ALG3	0.824530985	1.84E-31
UCS	Cell metabolism gene	RPL35	PGP	0.82595541	1.18E-31
UCS	Cell metabolism gene	RPL35	LSM4	0.826517779	9.89E-32
UCS	Cell metabolism gene	RPL35	TIMM17B	0.82814143	5.92E-32
UCS	Cell metabolism gene	RPL35	SSR4	0.828145207	5.92E-32
UCS	Cell metabolism gene	RPL35	GFER	0.82841963	5.42E-32
UCS	Cell metabolism gene	RPL35	POLE4	0.828933013	4.60E-32
UCS	Cell metabolism gene	RPL35	DGUOK	0.829454042	3.90E-32
UCS	Cell metabolism gene	RPL35	PPCDC	0.82976294	3.53E-32
UCS	Cell metabolism gene	RPL35	SNRPD3	0.829795665	3.49E-32
UCS	Cell metabolism gene	RPL35	PSMD13	0.831255844	2.18E-32
UCS	Cell metabolism gene	RPL35	SRM	0.831981804	1.72E-32
UCS	Cell metabolism gene	RPL35	FPGS	0.832730759	1.35E-32
UCS	Cell metabolism gene	RPL35	POLD4	0.834349584	7.93E-33
UCS	Cell metabolism gene	RPL35	PSMC1	0.836814919	3.48E-33
UCS	Cell metabolism gene	RPL35	PSMC5	0.837322847	2.94E-33
UCS	Cell metabolism gene	RPL35	TOMM40	0.838431849	2.02E-33
UCS	Cell metabolism gene	RPL35	PSME2	0.839487098	1.41E-33
UCS	Cell metabolism gene	RPL35	MIF	0.841520647	6.98E-34
UCS	Cell metabolism gene	RPL35	HMBS	0.848105493	6.73E-35
UCS	Cell metabolism gene	RPL35	GEMIN7	0.848650419	5.51E-35
UCS	Cell metabolism gene	RPL35	GEMIN6	0.849085637	4.70E-35
UCS	Cell metabolism gene	RPL35	PSMC3	0.851250071	2.12E-35
UCS	Cell metabolism gene	RPL35	PHPT1	0.852900092	1.14E-35
UCS	Cell metabolism gene	RPL35	PHKG2	0.853693694	8.45E-36
UCS	Cell metabolism gene	RPL35	EXOSC5	0.855715369	3.91E-36
UCS	Cell metabolism gene	RPL35	IDH3G	0.855979602	3.53E-36
UCS	Cell metabolism gene	RPL35	MVD	0.856264554	3.16E-36
UCS	Cell metabolism gene	RPL35	PSMD4	0.85656458	2.81E-36
UCS	Cell metabolism gene	RPL35	GMPPA	0.85845236	1.35E-36
UCS	Cell metabolism gene	RPL35	NANS	0.858665718	1.24E-36
UCS	Cell metabolism gene	RPL35	PTGES2	0.860503309	5.99E-37
UCS	Cell metabolism gene	RPL35	TIMM10	0.863840491	1.55E-37
UCS	Cell metabolism gene	RPL35	POLR2F	0.865779636	6.98E-38
UCS	Cell metabolism gene	RPL35	PMPCA	0.869472436	1.47E-38
UCS	Cell metabolism gene	RPL35	WBSCR22	0.869502167	1.45E-38
UCS	Cell metabolism gene	RPL35	MTX1	0.870287862	1.03E-38
UCS	Cell metabolism gene	RPL35	ITPA	0.871268126	6.75E-39
UCS	Cell metabolism gene	RPL35	GUK1	0.87158347	5.89E-39
UCS	Cell metabolism gene	RPL35	SSR2	0.872096267	4.70E-39
UCS	Cell metabolism gene	RPL35	EBP	0.872643011	3.70E-39
UCS	Cell metabolism gene	RPL35	EXOSC4	0.883024113	3.10E-41
UCS	Cell metabolism gene	RPL35	APRT	0.888459938	2.11E-42
UCS	Cell metabolism gene	RPL35	SLC27A5	0.892464101	2.66E-43
UCS	Cell metabolism gene	RPL35	POLR2J	0.89569535	4.71E-44
UCS	Cell metabolism gene	RPL35	ACOT8	0.895960259	4.07E-44
UCS	Cell metabolism gene	RPL35	POLR2H	0.896186293	3.60E-44
UCS	Cell metabolism gene	RPL35	PSMB3	0.902070284	1.30E-45
UCS	Cell metabolism gene	RPL35	PSMB7	0.904810574	2.57E-46
UCS	Cell metabolism gene	RPL35	TIMM13	0.905767546	1.45E-46
UCS	Cell metabolism gene	RPL35	POLR2I	0.906432054	9.64E-47
UCS	Cell metabolism gene	RPL35	DPM3	0.909467891	1.46E-47
UCS	Cell metabolism gene	RPL35	TIMM50	0.910438323	7.88E-48
UCS	Cell metabolism gene	RPL35	PGLS	0.91080607	6.23E-48
UCS	Cell metabolism gene	RPL35	TIMM8B	0.915492382	2.82E-49
UCS	Cell metabolism gene	RPL35	PFDN5	0.916029486	1.95E-49
UCS	Cell metabolism gene	RPL35	DPM2	0.916402705	1.51E-49
UCS	Cell metabolism gene	RPL35	SNRPD2	0.917925221	5.25E-50
UCS	Cell metabolism gene	RPL35	FAU	0.943704578	1.71E-59
UCS	CGC	RPL35	MGMT	0.827313927	7.70E-32
UCS	CGC	RPL35	ASPSCR1	0.835693808	5.07E-33
UCS	CGC	RPL35	SDHAF2	0.843303676	3.74E-34
UCS	CGC	RPL35	TFPT	0.854171657	7.05E-36
UCS	CGC	RPL35	RBM10	0.871135315	7.15E-39
UCS	Epifactor	RPL35	PELP1	0.801213714	1.56E-28
UCS	Epifactor	RPL35	PRMT1	0.807649379	2.66E-29
UCS	Epifactor	RPL35	DMAP1	0.81302448	5.77E-30
UCS	Epifactor	RPL35	ZGPAT	0.818465613	1.17E-30
UCS	Epifactor	RPL35	RRP8	0.827483843	7.30E-32
UCS	Epifactor	RPL35	RUVBL2	0.832442325	1.48E-32
UCS	Epifactor	RPL35	PPP4C	0.838622721	1.89E-33
UCS	Epifactor	RPL35	LAS1L	0.845041528	2.03E-34
UCS	Epifactor	RPL35	NOC2L	0.845855403	1.51E-34
UCS	Epifactor	RPL35	MBD3	0.849673291	3.79E-35
UCS	Epifactor	RPL35	TFPT	0.854171657	7.05E-36
UCS	Epifactor	RPL35	EXOSC5	0.855715369	3.91E-36
UCS	Epifactor	RPL35	C17orf49	0.863447702	1.82E-37
UCS	Epifactor	RPL35	CCDC101	0.868148613	2.58E-38
UCS	Epifactor	RPL35	EXOSC4	0.883024113	3.10E-41
UCS	Epifactor	RPL35	INO80E	0.886770243	4.94E-42
UCS	Epifactor	RPL35	FBL	0.890227537	8.54E-43
UCS	Epifactor	RPL35	PRPF31	0.894203123	1.05E-43
UCS	Epifactor	RPL35	TAF10	0.913929576	8.07E-49
UCS	Epifactor	RPL35	BRMS1	0.914225585	6.62E-49
UCS	Epifactor	RPL35	SIRT6	0.914787698	4.54E-49
UCS	Epifactor	RPL35	ZNHIT1	0.916246532	1.68E-49
UCS	IUPHAR	RPL35	MPST	0.800908399	1.69E-28
UCS	IUPHAR	RPL35	MAP3K11	0.803175448	9.16E-29
UCS	IUPHAR	RPL35	SMPD2	0.806963441	3.22E-29
UCS	IUPHAR	RPL35	PRMT1	0.807649379	2.66E-29
UCS	IUPHAR	RPL35	PPIA	0.809484004	1.59E-29
UCS	IUPHAR	RPL35	PSMB1	0.812693545	6.34E-30
UCS	IUPHAR	RPL35	EGLN2	0.814212106	4.09E-30
UCS	IUPHAR	RPL35	ATP6V0B	0.822258623	3.70E-31
UCS	IUPHAR	RPL35	SIRT3	0.848604774	5.61E-35
UCS	IUPHAR	RPL35	PHKG2	0.853693694	8.45E-36
UCS	IUPHAR	RPL35	MVD	0.856264554	3.16E-36
UCS	IUPHAR	RPL35	PTGES2	0.860503309	5.99E-37
UCS	IUPHAR	RPL35	SLC27A5	0.892464101	2.66E-43
UCS	IUPHAR	RPL35	SIRT6	0.914787698	4.54E-49
UCS	Kinase	RPL35	MAP3K11	0.803175448	9.16E-29
UCS	Kinase	RPL35	FASTK	0.811936585	7.89E-30
UCS	Kinase	RPL35	PHKG2	0.853693694	8.45E-36
UCS	TF	RPL35	RBCK1	0.808686045	1.99E-29
UCS	TF	RPL35	ZNF580	0.817032711	1.78E-30
UCS	TF	RPL35	ZGPAT	0.818465613	1.17E-30
UCS	TF	RPL35	DRAP1	0.820302287	6.71E-31
UCS	TF	RPL35	ZNF511	0.822280126	3.68E-31
UCS	TF	RPL35	USF1	0.826152805	1.11E-31
UCS	TF	RPL35	ZNF32	0.831924064	1.76E-32
UCS	TF	RPL35	REXO4	0.832536366	1.44E-32
UCS	TF	RPL35	IRF3	0.833982412	8.95E-33
UCS	TF	RPL35	GLI4	0.838399141	2.04E-33
UCS	TF	RPL35	ZNF428	0.841813339	6.31E-34
UCS	TF	RPL35	ZBTB48	0.842622629	4.75E-34
UCS	TF	RPL35	MBD3	0.849673291	3.79E-35
UCS	TF	RPL35	ETV2	0.850121169	3.21E-35
UCS	TF	RPL35	THAP3	0.859529119	8.82E-37
UCS	TF	RPL35	ZNF688	0.864922471	9.95E-38
UCS	TF	RPL35	ZNF581	0.870180229	1.08E-38
UCS	TF	RPL35	ZNF524	0.874022138	2.01E-39
UCS	TF	RPL35	THAP7	0.877893703	3.48E-40
UCS	TF	RPL35	ZNF787	0.885054534	1.15E-41
UCS	TSG	RPL35	STUB1	0.831161928	2.25E-32
UCS	TSG	RPL35	IRF3	0.833982412	8.95E-33
UCS	TSG	RPL35	PARK7	0.839281789	1.51E-33
UCS	TSG	RPL35	ZBTB48	0.842622629	4.75E-34
UCS	TSG	RPL35	ST20	0.843890204	3.05E-34
UCS	TSG	RPL35	GABARAP	0.846606408	1.16E-34
UCS	TSG	RPL35	SIRT3	0.848604774	5.61E-35
UCS	TSG	RPL35	GLTSCR2	0.850901801	2.41E-35
UCS	TSG	RPL35	GNB2L1	0.864600833	1.14E-37
UCS	TSG	RPL35	NPRL2	0.895159744	6.30E-44
UCS	TSG	RPL35	TSSC4	0.89702493	2.27E-44
UCS	TSG	RPL35	BRMS1	0.914225585	6.62E-49
UCS	TSG	RPL35	SIRT6	0.914787698	4.54E-49
UCS	TSG	RPL35	GADD45GIP1	0.924786938	3.43E-52
UVM	Cell metabolism gene	RPL35	MPST	0.822625395	8.14E-21
UVM	Cell metabolism gene	RPL35	SSR2	0.833844089	7.99E-22
UVM	Cell metabolism gene	RPL35	FAU	0.877915843	1.15E-26
UVM	CGC	RPL35	NACA	0.802430902	3.62E-19
UVM	Epifactor	RPL35	FBL	0.836071776	4.93E-22
UVM	IUPHAR	RPL35	MPST	0.822625395	8.14E-21
UVM	TF	RPL35	ZNF581	0.802804331	3.39E-19
UVM	TSG	RPL35	GNB2L1	0.852560078	1.10E-23
UVM	TSG	RPL35	GLTSCR2	0.872001393	6.50E-26

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL35	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL35	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL35	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPL35	RPS23	1.85076760664576	0.000364991836249828
COAD	RPL35	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL35	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL35	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL35	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL35	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL35	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL35	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL35	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPL35	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPL35	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL35	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL35	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL35	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL35	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPL35	RPS23	-2.03658159814007	0.046875
KIRC	RPL35	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL35	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL35	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL35	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL35	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL35	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL35	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL35	RPL37	-2.87198822058464	8.03913394748564e-12
KIRC	RPL35	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL35	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL35

PSTPIP1, PRKAA1, AGO4, TUBB2B, SGSM3, HDGF, ARRB2, CUL3, CUL4B, CUL5, CDK2, CUL1, COPS5, CAND1, NEDD8, RPS8, RPL6, RPL36, RPL7, RPS7, RPL31, RPS20, RPS24, RPSA, RPL30, RPL23A, RPL27A, RPL18, RPL11, RPL7A, RPL14, RPS19, RPS3A, RPL38, RPL10L, FN1, VCAM1, ITGA4, PAN2, CD81, IGSF8, ICAM1, LAMC3, ADH4, CDKN1A, ACTN2, MAX, TARDBP, PARP1, EIF3CL, HNRNPU, PRPSAP1, RPL17, EIF3D, G3BP1, RPL26, RPS27, RPS11, RPS12, SND1, Fbxl16, CEP250, CUL7, TXNDC16, LUZP4, LGALS3, PABPC1, RNPS1, RPL10, RPL10A, RPL12, RPL13, RPL13A, RPL15, ATP1B3, RPL18A, RPL19, RPL21, RPL22, RPL23, RPL24, RPL26L1, RPL27, RPL28, RPL3, RPL34, RPL5, RPLP0, RPN1, RPS10, RPS13, RPS15A, RPS16, RPS18, RPS25, RPS3, RPS4X, RPS5, RPS6, RPS9, UBA52, RPL35A, RPL37A, RPL4, RPL8, RPL9, RPLP2, RPS14, RPS2, RPS23, LOC101929876, RPS26, SFN, gag, HIST1H3E, NPM1, TMPO, Ccdc77, Rrbp1, Brwd3, CRBN, ZNF746, RRS1, CYLD, COX15, PDHA1, VDAC1, TRIM25, UBE2A, BRCA1, AURKA, CCT8, CIRH1A, COX5A, DNTTIP2, EIF4G1, EXOSC2, FARSA, GNL2, GTF2H1, INTS5, LIAS, MARS, MASTL, MAT2A, MBTPS2, MED17, MED22, MTBP, NIP7, NOL8, NUTF2, PHF5A, POLR2B, PPCS, PRIM2, PSMB6, PSMC2, PSMD12, RBFA, RFC5, RPL32, RPL35, RPS27A, RPS28, RRM1, SF3B1, SGOL1, SNRNP70, SRSF7, TBCB, TOMM22, TUBGCP4, WDR36, XPO1, ZNF511, API5, TRIP4, AAR2, EFTUD2, RNF4, CHD3, CHD4, RNF31, SPDL1, RIOK1, ESR2, HEXIM1, MEPCE, LARP7, HERC2, KCMF1, AGR2, RECQL4, REST, ZFP36L2, MYC, METTL14, RC3H1, RC3H2, PHB, CREBBP, MAPT, USP14, NR2C2, PPP1CC, GBF1, NIN, VRK1, HIST1H4A, ITFG1, HMGB1, CLUAP1, BIRC3, STAU1, NFX1, WWP2, Dnajc17, TEX101, LRRK2, CMTR1, PLEKHA4, RAD18, PINK1, FANCD2, NHLRC2, HCVgp1, ZC3H18, GRB7, PTPN6, C10orf120, CXorf22, TBPL1, SNIP1, ORF8, UBR5, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, ACACA, FASN, LRRC59, BRD4, Apc2, RBM39, FBP1, MKRN1, BKRF1, RIN3, SETD8, REPIN1, SET, REXO4, LIN28A, RPL7L1, HIST1H2AI, HIST1H2BD, H1FX, RSL1D1, TFAM, KRR1, RALY, MRPS7, MRPS10, DDX18, RRP1B, HADHB, KIFC1, WDR46, HIST1H1C, SRP14, PARK2, UFL1, DDRGK1, TRIM37, FZR1, NUDCD2, NAA40, MRPL9, STAU2, RANBP6, TRIM71, PABPC4L, NMNAT1, CEBPZ, RBM19, AKAP17A, TRIM26, RSBN1, ZNF346, RPL36AL, RPS15, ZC3HAV1, CLIC2, MRPL28, SDAD1, MRPL11, TTF1, MRPS35, HP1BP3, FTL, PPAN-P2RY11, YBX1, MRPS31, RPS17, MRPS24, DDX24, NSA2, ZNF770, GLYR1, MRPL32, FCF1, NCL, MRPS11, PAK1IP1, WDR74, C7orf50, BOP1, MRPS9, DHX30, MRPS30, NOC4L, PRKRA, MRPS21, NOP16, CCDC137, MRPL35, MRPS34, DKC1, KIAA0020, PURB, SRSF6, RSL24D1, PTCD3, MRPL2, ZC3H8, FTSJ3, GTPBP4, MRPL42, DDX50, APOBEC3F, MAGEB2, ZNF768, OASL, GAR1, NIFK, MRPL20, MRPS5, DDX56, SREK1, RRP12, DDX10, MRPL17, NKRF, MRPS14, SF3B2, MRPL48, MRPS23, NOL10, ABT1, IPO5, GPATCH4, MRPL55, LTV1, MRPS18C, MRPL15, GLTSCR2, MRPL52, MRPL30, MRPL40, MRPL41, HIST1H2AG, ZBTB11, MRPL16, MPHOSPH10, HIST2H2AB, ZNF512, DDX27, ZNF574, VPRBP, PURA, KRI1, MRPS18A, DAP3, MRPS26, KNOP1, MRPL18, MAK16, AATF, UTP23, DDX31, UBE2O, MRPL45, MRPL50, YBX3, ZCRB1, LARP1, MRPL47, CHERP, NOC3L, NAT10, MRPL27, MRPS27, CTCF, DDX54, MRPL24, PAPD5, RPF2, MRPS33, MOV10, MRPL46, U2SURP, MRPL13, BMS1, MYBBP1A, RPF1, KPNB1, RBM17, PRKRIR, NOC2L, RBM34, MRPS25, EPB41L5, ZCCHC3, SURF6, IPO7, MRPS18B, GADD45GIP1, SSB, MRPL3, FAM111A, BTF3, FBXW7, NLRP7, RCHY1, PDE4B, KLF4, SP1, TLX1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL35	chr9	127620141	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
RPL35	chr9	127620224	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL35	chr9	127620268	T	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL35	chr9	127620275	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL35	chr9	127620338	C	G	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_19	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL35	chr9	127620356	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL35	chr9	127620480	CAT	C	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL35	chr9	127623856	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL35	chr9	127624406	C	T	single_nucleotide_variant	Benign	not_provided

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL35	BRCA	chr9	127620210	127620210	G	C	Missense_Mutation	p.A120G	4
RPL35	BRCA	chr9	127620332	127620332	C	G	Missense_Mutation	p.K79N	3
RPL35	ESCA	chr9	127620266	127620266	G	T	Missense_Mutation	p.N101K	3
RPL35	PAAD	chr9	127620235	127620235	G	A	Missense_Mutation	p.R112W	3
RPL35	BLCA	chr9	127623766	127623766	C	T	Silent	p.L24L	2
RPL35	STAD	chr9	127620344	127620344	G	A	Silent	p.G75G	2
RPL35	UCEC	chr9	127620293	127620293	G	A	Silent	p.R92	2
RPL35	PAAD	chr9	127620235	127620235	G	A	Missense_Mutation		2
RPL35	KIRP	chr9	127622502	127622502	A	G	Missense_Mutation	p.I61T	1
RPL35	READ	chr9	127620295	127620295	G	A	Missense_Mutation	p.R92C	1
RPL35	LGG	chr9	127620260	127620260	C	A	Missense_Mutation	p.K103N	1
RPL35	SKCM	chr9	127620225	127620225	G	A	Missense_Mutation	p.P115L	1
RPL35	LGG	chr9	127623796	127623798	CTT	-	In_Frame_Del	p.K14del	1
RPL35	SKCM	chr9	127620288	127620288	C	T	Missense_Mutation	p.R94Q	1
RPL35	CESC	chr9	127622541	127622541	C	T	Missense_Mutation		1
RPL35	LGG	chr9	127620260	127620260	C	A	Missense_Mutation		1
RPL35	CESC	chr9	127620257	127620257	G	T	Silent		1
RPL35	LIHC	chr9	127622525	127622525	G	A	Silent		1
RPL35	TGCT	chr9	127624216	127624216	C	A	Missense_Mutation		1
RPL35	CESC	chr9	127622541	127622541	C	T	Missense_Mutation	p.R48Q	1
RPL35	LIHC	chr9	127622525	127622525	G	A	Silent	p.S53S	1
RPL35	CESC	chr9	127623691	127623691	C	T	RNA	NULL	1
RPL35	LIHC	chr9	127620764	127620764	G	-	Frame_Shift_Del	p.P92fs	1
RPL35	COAD	chr9	127620219	127620219	C	T	Missense_Mutation	p.R117Q	1
RPL35	MESO	chr9	127623762	127623762	C	T	Missense_Mutation	p.V26M	1
RPL35	COAD	chr9	127623796	127623798	CTT	-	In_Frame_Del	p.14_15del	1
RPL35	OV	chr9	127620287	127620287	C	T	Silent	p.R94	1
RPL35	BLCA	chr9	127623766	127623766	C	T	Silent		1
RPL35	BLCA	chr9	127624226	127624226	G	C	Missense_Mutation		1
RPL35	ESCA	chr9	127620266	127620266	G	T	Missense_Mutation		1

Copy number variation (CNV) of RPL35
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL35
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
98970	COAD	TCGA-AA-3973-01A	ABHD11	chr7	73152823	-	RPL35	chr9	127620282	-
98970	COAD	TCGA-AA-A03F-01A	BTF3	chr5	72794408	+	RPL35	chr9	127620315	-
98970	N/A	AI682966	IGFBP5	chr2	217537116	+	RPL35	chr9	127624210	-
98970	N/A	AA643790	MRPL42	chr12	93864098	+	RPL35	chr9	127620162	+
98970	ESCA	TCGA-LN-A4A2	NAV3	chr12	78415642	+	RPL35	chr9	127623834	-
98970	N/A	AA578892	PTPRT	chr20	41136512	+	RPL35	chr9	127620164	+
87239	N/A	CN394906	RPL35	chr9	127620281	+	C1orf43	chr1	154193017	-
92717	N/A	BI859351	RPL35	chr9	127620162	-	CELF1	chr11	47491861	-
92374	N/A	BF802262	RPL35	chr9	127624236	+	DIAPH1	chr5	140896229	-
76597	N/A	CF124215	RPL35	chr9	127620162	-	EXPH5	chr11	108390476	+
81159	N/A	BG029809	RPL35	chr9	127620162	-	FAM46A	chr6	82351668	+
76597	N/A	CA433490	RPL35	chr9	127620282	+	NOC2L	chr1	892529	+
84888	N/A	BG575847	RPL35	chr9	127620162	-	OSTM1	chr6	108414916	+
76597	COAD	TCGA-AA-3488-01A	RPL35	chr9	127623729	-	PDF	chr16	69363918	-
87343	N/A	AA523460	RPL35	chr9	127620162	-	PLEKHF2	chr8	96157094	+
102722	N/A	CD240085	RPL35	chr9	127620162	-	USP48	chr1	22082046	+
98970	LUSC	TCGA-85-8276	RTKN	chr2	74668833	-	RPL35	chr9	127622505	-
98970	N/A	AA603567	SCAI	chr9	127805150	-	RPL35	chr9	127620672	-
98970	LIHC	TCGA-DD-AACK-01A	SERPINA1	chr14	94844786	-	RPL35	chr9	127624240	-
98970	N/A	EC557702	TRPC6	chr11	101417849	-	RPL35	chr9	127623835	-
98970	N/A	AA502485	TXNRD1	chr12	104675198	+	RPL35	chr9	127620162	+
98970	N/A	AI056486	WDR38	chr9	127620346	+	RPL35	chr9	127622462	+
98970	N/A	AI094699	WDR38	chr9	127620294	+	RPL35	chr9	127620296	+
98970	N/A	BF245224	WDR38	chr9	127620162	-	RPL35	chr9	127624225	-
98970	N/A	BF245306	WDR38	chr9	127620164	-	RPL35	chr9	127623750	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
UVM	RPL35	0.435256294682412	-0.831820238215757	0.000612192598224687	0.000202471813925643	0.000228207995620598	80
LGG	RPL35	0.577351880188064	-0.549303354006803	0.00159078721752838	0.00132466485318669	0.00176939728279747	525
LUSC	RPL35	0.811510270835563	-0.208858235501839	0.00769176654397133	0.00735262813887501	0.00762132209427841	545
KIRC	RPL35	1.29766414524979	0.260565836919375	0.00769790200980689	0.00898012076866245	0.00770801555403325	604
KIRC	RPL35	1.29766414524979	0.260565836919375	0.00769790200980689	0.00898012076866245	0.00770801555403325	604

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	RPL35	0.00266627765671202	0.075
ACC	RPL35	0.00877960355169581	0.24
SARC	RPL35	0.0136019821254408	0.35

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL35	5.77401782068556e-05	0.0019
SARC	RPL35	0.00462963324828614	0.15

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1260899	Anemia, Diamond-Blackfan	1	GENOMICS_ENGLAND;ORPHANET
C2931850	Aase Smith syndrome 2	1	ORPHANET