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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL39L (NCBI Gene ID:116832)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL39L
	Gene ID: 116832
	Gene Symbol	RPL39L
	Gene ID	116832
	Gene Name	ribosomal protein L39 like
	Synonyms	L39-2\|RPL39L1
	Cytomap	3q27.3
	Type of Gene	protein-coding
	Description	60S ribosomal protein L39-like60S ribosomal protein L39-2large ribosomal subunit protein eL39-likeribosomal protein L39-like 1ribosomal protein L39-like protein
	Modification date	20200313
	UniProtAcc	Q96EH5

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL39L	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL39L[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL39L	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000296277	186845786	186845850	3UTR-3UTR

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
UCEC	RPL39L	3.62356809518695	0.015625

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
GBM	RPL39L	-0.118487572	0.004897313

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL39L (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	CGC	RPL39L	EZH2	0.803772312	2.98E-11
CHOL	Epifactor	RPL39L	UBE2T	0.802321142	3.44E-11
CHOL	Epifactor	RPL39L	EZH2	0.803772312	2.98E-11
CHOL	IUPHAR	RPL39L	EZH2	0.803772312	2.98E-11
CHOL	TF	RPL39L	E2F1	0.810414821	1.53E-11
CHOL	TSG	RPL39L	EZH2	0.803772312	2.98E-11
CHOL	TSG	RPL39L	E2F1	0.810414821	1.53E-11
THYM	Cell metabolism gene	RPL39L	TUBA1B	0.802107391	1.22E-28
THYM	Cell metabolism gene	RPL39L	TK1	0.803183135	9.14E-29
THYM	Cell metabolism gene	RPL39L	GNA15	0.804924452	5.67E-29
THYM	Cell metabolism gene	RPL39L	LSM3	0.805831602	4.41E-29
THYM	Cell metabolism gene	RPL39L	PAFAH1B3	0.820198899	6.93E-31
THYM	Cell metabolism gene	RPL39L	PSMA5	0.822668393	3.27E-31
THYM	Cell metabolism gene	RPL39L	PSMA4	0.823111139	2.85E-31
THYM	Cell metabolism gene	RPL39L	POLD1	0.82651474	9.90E-32
THYM	Cell metabolism gene	RPL39L	DUT	0.830438077	2.84E-32
THYM	Cell metabolism gene	RPL39L	PSMB2	0.837966022	2.36E-33
THYM	Cell metabolism gene	RPL39L	ADA	0.839762514	1.28E-33
THYM	Cell metabolism gene	RPL39L	DTYMK	0.845282737	1.86E-34
THYM	Cell metabolism gene	RPL39L	TKT	0.859638362	8.44E-37
THYM	Cell metabolism gene	RPL39L	PSMA6	0.895853051	4.32E-44
THYM	Cell metabolism gene	RPL39L	IDH2	0.910703077	6.65E-48
THYM	CGC	RPL39L	FANCA	0.806162069	4.03E-29
THYM	CGC	RPL39L	RECQL4	0.816548757	2.06E-30
THYM	CGC	RPL39L	POLD1	0.82651474	9.90E-32
THYM	CGC	RPL39L	EZH2	0.830886544	2.46E-32
THYM	CGC	RPL39L	BCL2L12	0.832489924	1.46E-32
THYM	CGC	RPL39L	FANCG	0.839750353	1.29E-33
THYM	CGC	RPL39L	FEN1	0.877860182	3.53E-40
THYM	CGC	RPL39L	IDH2	0.910703077	6.65E-48
THYM	Epifactor	RPL39L	ENY2	0.803162259	9.19E-29
THYM	Epifactor	RPL39L	AURKA	0.805056194	5.47E-29
THYM	Epifactor	RPL39L	ASF1B	0.807206791	3.01E-29
THYM	Epifactor	RPL39L	PPM1G	0.808237319	2.26E-29
THYM	Epifactor	RPL39L	H2AFX	0.808256239	2.24E-29
THYM	Epifactor	RPL39L	RAD54L	0.809938701	1.40E-29
THYM	Epifactor	RPL39L	RUVBL1	0.812027386	7.68E-30
THYM	Epifactor	RPL39L	RAD51	0.812872973	6.02E-30
THYM	Epifactor	RPL39L	HIST1H2BH	0.816304043	2.21E-30
THYM	Epifactor	RPL39L	CENPA	0.819157107	9.48E-31
THYM	Epifactor	RPL39L	CHEK1	0.82963527	3.68E-32
THYM	Epifactor	RPL39L	EZH2	0.830886544	2.46E-32
THYM	Epifactor	RPL39L	SAP30	0.831730551	1.87E-32
THYM	Epifactor	RPL39L	AURKB	0.843329748	3.71E-34
THYM	Epifactor	RPL39L	UBE2T	0.861339627	4.28E-37
THYM	Epifactor	RPL39L	SUV39H1	0.862770935	2.40E-37
THYM	Epifactor	RPL39L	CHAF1A	0.8650012	9.63E-38
THYM	Epifactor	RPL39L	H2AFZ	0.868904299	1.87E-38
THYM	IUPHAR	RPL39L	UCHL3	0.800221237	2.04E-28
THYM	IUPHAR	RPL39L	DPP3	0.800510566	1.88E-28
THYM	IUPHAR	RPL39L	TP53RK	0.803145364	9.23E-29
THYM	IUPHAR	RPL39L	AURKA	0.805056194	5.47E-29
THYM	IUPHAR	RPL39L	GRK6	0.807226434	2.99E-29
THYM	IUPHAR	RPL39L	EGLN3	0.808745968	1.95E-29
THYM	IUPHAR	RPL39L	VRK3	0.809662121	1.51E-29
THYM	IUPHAR	RPL39L	LETM1	0.812462106	6.78E-30
THYM	IUPHAR	RPL39L	BIRC5	0.826413106	1.02E-31
THYM	IUPHAR	RPL39L	CHEK1	0.82963527	3.68E-32
THYM	IUPHAR	RPL39L	EZH2	0.830886544	2.46E-32
THYM	IUPHAR	RPL39L	PSMB2	0.837966022	2.36E-33
THYM	IUPHAR	RPL39L	ADA	0.839762514	1.28E-33
THYM	IUPHAR	RPL39L	AURKB	0.843329748	3.71E-34
THYM	IUPHAR	RPL39L	PLK1	0.843413068	3.60E-34
THYM	IUPHAR	RPL39L	SUV39H1	0.862770935	2.40E-37
THYM	IUPHAR	RPL39L	IDH2	0.910703077	6.65E-48
THYM	Kinase	RPL39L	TP53RK	0.803145364	9.23E-29
THYM	Kinase	RPL39L	AURKA	0.805056194	5.47E-29
THYM	Kinase	RPL39L	GRK6	0.807226434	2.99E-29
THYM	Kinase	RPL39L	VRK3	0.809662121	1.51E-29
THYM	Kinase	RPL39L	CHEK1	0.82963527	3.68E-32
THYM	Kinase	RPL39L	AURKB	0.843329748	3.71E-34
THYM	Kinase	RPL39L	PLK1	0.843413068	3.60E-34
THYM	TF	RPL39L	MXD3	0.805936662	4.29E-29
THYM	TF	RPL39L	TFDP2	0.810129297	1.32E-29
THYM	TF	RPL39L	CENPA	0.819157107	9.48E-31
THYM	TF	RPL39L	PIN1	0.823173687	2.80E-31
THYM	TF	RPL39L	GTF3A	0.843285677	3.77E-34
THYM	TF	RPL39L	E2F1	0.845415355	1.77E-34
THYM	TF	RPL39L	MYBL2	0.85597689	3.53E-36
THYM	TSG	RPL39L	H2AFX	0.808256239	2.24E-29
THYM	TSG	RPL39L	EGLN3	0.808745968	1.95E-29
THYM	TSG	RPL39L	RAD51C	0.817024826	1.79E-30
THYM	TSG	RPL39L	PIN1	0.823173687	2.80E-31
THYM	TSG	RPL39L	CHEK1	0.82963527	3.68E-32
THYM	TSG	RPL39L	EZH2	0.830886544	2.46E-32
THYM	TSG	RPL39L	MYO1A	0.836250709	4.21E-33
THYM	TSG	RPL39L	FANCG	0.839750353	1.29E-33
THYM	TSG	RPL39L	PLK1	0.843413068	3.60E-34
THYM	TSG	RPL39L	E2F1	0.845415355	1.77E-34
UCS	Cell metabolism gene	RPL39L	TUBA1B	0.802107391	1.22E-28
UCS	Cell metabolism gene	RPL39L	TK1	0.803183135	9.14E-29
UCS	Cell metabolism gene	RPL39L	GNA15	0.804924452	5.67E-29
UCS	Cell metabolism gene	RPL39L	LSM3	0.805831602	4.41E-29
UCS	Cell metabolism gene	RPL39L	PAFAH1B3	0.820198899	6.93E-31
UCS	Cell metabolism gene	RPL39L	PSMA5	0.822668393	3.27E-31
UCS	Cell metabolism gene	RPL39L	PSMA4	0.823111139	2.85E-31
UCS	Cell metabolism gene	RPL39L	POLD1	0.82651474	9.90E-32
UCS	Cell metabolism gene	RPL39L	DUT	0.830438077	2.84E-32
UCS	Cell metabolism gene	RPL39L	PSMB2	0.837966022	2.36E-33
UCS	Cell metabolism gene	RPL39L	ADA	0.839762514	1.28E-33
UCS	Cell metabolism gene	RPL39L	DTYMK	0.845282737	1.86E-34
UCS	Cell metabolism gene	RPL39L	TKT	0.859638362	8.44E-37
UCS	Cell metabolism gene	RPL39L	PSMA6	0.895853051	4.32E-44
UCS	Cell metabolism gene	RPL39L	IDH2	0.910703077	6.65E-48
UCS	CGC	RPL39L	FANCA	0.806162069	4.03E-29
UCS	CGC	RPL39L	RECQL4	0.816548757	2.06E-30
UCS	CGC	RPL39L	POLD1	0.82651474	9.90E-32
UCS	CGC	RPL39L	EZH2	0.830886544	2.46E-32
UCS	CGC	RPL39L	BCL2L12	0.832489924	1.46E-32
UCS	CGC	RPL39L	FANCG	0.839750353	1.29E-33
UCS	CGC	RPL39L	FEN1	0.877860182	3.53E-40
UCS	CGC	RPL39L	IDH2	0.910703077	6.65E-48
UCS	Epifactor	RPL39L	ENY2	0.803162259	9.19E-29
UCS	Epifactor	RPL39L	AURKA	0.805056194	5.47E-29
UCS	Epifactor	RPL39L	ASF1B	0.807206791	3.01E-29
UCS	Epifactor	RPL39L	PPM1G	0.808237319	2.26E-29
UCS	Epifactor	RPL39L	H2AFX	0.808256239	2.24E-29
UCS	Epifactor	RPL39L	RAD54L	0.809938701	1.40E-29
UCS	Epifactor	RPL39L	RUVBL1	0.812027386	7.68E-30
UCS	Epifactor	RPL39L	RAD51	0.812872973	6.02E-30
UCS	Epifactor	RPL39L	HIST1H2BH	0.816304043	2.21E-30
UCS	Epifactor	RPL39L	CENPA	0.819157107	9.48E-31
UCS	Epifactor	RPL39L	CHEK1	0.82963527	3.68E-32
UCS	Epifactor	RPL39L	EZH2	0.830886544	2.46E-32
UCS	Epifactor	RPL39L	SAP30	0.831730551	1.87E-32
UCS	Epifactor	RPL39L	AURKB	0.843329748	3.71E-34
UCS	Epifactor	RPL39L	UBE2T	0.861339627	4.28E-37
UCS	Epifactor	RPL39L	SUV39H1	0.862770935	2.40E-37
UCS	Epifactor	RPL39L	CHAF1A	0.8650012	9.63E-38
UCS	Epifactor	RPL39L	H2AFZ	0.868904299	1.87E-38
UCS	IUPHAR	RPL39L	UCHL3	0.800221237	2.04E-28
UCS	IUPHAR	RPL39L	DPP3	0.800510566	1.88E-28
UCS	IUPHAR	RPL39L	TP53RK	0.803145364	9.23E-29
UCS	IUPHAR	RPL39L	AURKA	0.805056194	5.47E-29
UCS	IUPHAR	RPL39L	GRK6	0.807226434	2.99E-29
UCS	IUPHAR	RPL39L	EGLN3	0.808745968	1.95E-29
UCS	IUPHAR	RPL39L	VRK3	0.809662121	1.51E-29
UCS	IUPHAR	RPL39L	LETM1	0.812462106	6.78E-30
UCS	IUPHAR	RPL39L	BIRC5	0.826413106	1.02E-31
UCS	IUPHAR	RPL39L	CHEK1	0.82963527	3.68E-32
UCS	IUPHAR	RPL39L	EZH2	0.830886544	2.46E-32
UCS	IUPHAR	RPL39L	PSMB2	0.837966022	2.36E-33
UCS	IUPHAR	RPL39L	ADA	0.839762514	1.28E-33
UCS	IUPHAR	RPL39L	AURKB	0.843329748	3.71E-34
UCS	IUPHAR	RPL39L	PLK1	0.843413068	3.60E-34
UCS	IUPHAR	RPL39L	SUV39H1	0.862770935	2.40E-37
UCS	IUPHAR	RPL39L	IDH2	0.910703077	6.65E-48
UCS	Kinase	RPL39L	TP53RK	0.803145364	9.23E-29
UCS	Kinase	RPL39L	AURKA	0.805056194	5.47E-29
UCS	Kinase	RPL39L	GRK6	0.807226434	2.99E-29
UCS	Kinase	RPL39L	VRK3	0.809662121	1.51E-29
UCS	Kinase	RPL39L	CHEK1	0.82963527	3.68E-32
UCS	Kinase	RPL39L	AURKB	0.843329748	3.71E-34
UCS	Kinase	RPL39L	PLK1	0.843413068	3.60E-34
UCS	TF	RPL39L	MXD3	0.805936662	4.29E-29
UCS	TF	RPL39L	TFDP2	0.810129297	1.32E-29
UCS	TF	RPL39L	CENPA	0.819157107	9.48E-31
UCS	TF	RPL39L	PIN1	0.823173687	2.80E-31
UCS	TF	RPL39L	GTF3A	0.843285677	3.77E-34
UCS	TF	RPL39L	E2F1	0.845415355	1.77E-34
UCS	TF	RPL39L	MYBL2	0.85597689	3.53E-36
UCS	TSG	RPL39L	H2AFX	0.808256239	2.24E-29
UCS	TSG	RPL39L	EGLN3	0.808745968	1.95E-29
UCS	TSG	RPL39L	RAD51C	0.817024826	1.79E-30
UCS	TSG	RPL39L	PIN1	0.823173687	2.80E-31
UCS	TSG	RPL39L	CHEK1	0.82963527	3.68E-32
UCS	TSG	RPL39L	EZH2	0.830886544	2.46E-32
UCS	TSG	RPL39L	MYO1A	0.836250709	4.21E-33
UCS	TSG	RPL39L	FANCG	0.839750353	1.29E-33
UCS	TSG	RPL39L	PLK1	0.843413068	3.60E-34
UCS	TSG	RPL39L	E2F1	0.845415355	1.77E-34

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUAD	RPL39L	RPL38	-1.66722943744988	0.000257795914027732
KIRP	RPL39L	RPL27A	-1.08412054314666	0.000280400272458792
LUSC	RPL39L	RPL38	-2.00110253296947	0.00049723236196648
KIRP	RPL39L	RPS14	-1.10710481020121	0.00114433001726866
PRAD	RPL39L	RPL29	1.34120891282909	0.00141303901136259
PRAD	RPL39L	RPL14	1.1487848232634	0.00321821289681976
COAD	RPL39L	RPL29	2.01531946700608	0.00390031933784485
ESCA	RPL39L	RPL15	1.76629417535644	0.0048828125
THCA	RPL39L	FAU	1.18509450470262	0.0152379297688856
STAD	RPL39L	RPL29	-1.21862598776416	0.0227867118082941
COAD	RPL39L	RPL27A	1.10401148181609	0.0291509032249451
KIRP	RPL39L	FAU	-1.04355048353271	0.0309218638576567
PRAD	RPL39L	RPL38	-1.37307294389303	0.0319785302138518
STAD	RPL39L	RPL27A	1.38102128420159	0.0341199110262096
THCA	RPL39L	RPS14	1.18855682463527	0.0484049760061147
HNSC	RPL39L	RPS25	2.24439018636525	1.07420805761649e-06
KIRC	RPL39L	FAU	-2.50135425883801	1.33253564327251e-08
KIRC	RPL39L	RPL27A	-2.44303111692082	1.37975994778687e-09
KIRP	RPL39L	RPL29	-3.32206918296731	2.00420618057251e-06
KIRC	RPL39L	RPL38	-2.47198269993031	2.66680331214666e-11
KIRP	RPL39L	RPL38	-2.05925877790715	4.97791916131974e-07
COAD	RPL39L	RPL14	2.38206887570306	6.03199005126954e-05
BRCA	RPL39L	RPL14	-2.51759496082785	6.20044644295049e-06
HNSC	RPL39L	RPL27A	1.53683147949011	7.17597035873042e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL39L

SRPK2, CCNDBP1, NRAS,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL39L	SKCM	chr3	186839028	186839028	G	A	Missense_Mutation	p.R21C	4
RPL39L	ESCA	chr3	186838997	186838997	G	T	Missense_Mutation		2
RPL39L	SKCM	chr3	186839019	186839019	G	A	Missense_Mutation	p.P24S	2
RPL39L	STAD	chr3	186839075	186839075	T	A	Missense_Mutation	p.K5M	2
RPL39L	UCEC	chr3	186838991	186838991	C	T	Missense_Mutation	p.S33N	2
RPL39L	COAD	chr3	186838941	186838941	C	A	Missense_Mutation	p.G50C	1
RPL39L	HNSC	chr3	186839064	186839064	T	A	Missense_Mutation	p.I9F	1
RPL39L	COAD	chr3	186839008	186839008	A	G	Silent	p.I27I	1
RPL39L	LUAD	chr3	186838966	186838966	C	T	Silent	p.R41R	1
RPL39L	ESCA	chr3	186838997	186838997	G	T	Missense_Mutation	p.P31H	1
RPL39L	READ	chr3	186839057	186839057	C	T	Missense_Mutation	p.R11Q	1
RPL39L	HNSC	chr3	186839066	186839066	G	C	Missense_Mutation		1
RPL39L	HNSC	chr3	186838972	186838972	G	T	Silent		1
RPL39L	HNSC	chr3	186839064	186839064	T	A	Missense_Mutation		1
RPL39L	HNSC	chr3	186838998	186838998	G	A	Missense_Mutation		1
RPL39L	HNSC	chr3	186839066	186839066	G	C	Missense_Mutation	p.T8S	1
RPL39L	HNSC	chr3	186838997	186838997	G	A	Missense_Mutation	p.P31L	1
RPL39L	HNSC	chr3	186838998	186838998	G	A	Missense_Mutation	p.P31S	1

Copy number variation (CNV) of RPL39L
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Fusion gene breakpoints (product of the structural variants (SVs)) across RPL39L
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100995	N/A	BG575264	RPL39L	chr3	186838736	-	DLG2	chr11	83212256	-
89400	N/A	BI492918	RPL39L	chr3	186882976	-	SETD5	chr3	9519838	-
76793	N/A	FN094363	RPL39L	chr3	186890144	+	SMNDC1	chr10	112058344	-
76793	BRCA	TCGA-A2-A0YT-01A	RPL39L	chr3	186857001	-	TIPARP	chr3	156411809	+
96543	N/A	AW021954	SETD5	chr3	9519838	+	RPL39L	chr3	186882976	+
96543	BRCA	TCGA-BH-A18V-06A	ST6GAL1	chr3	186769134	+	RPL39L	chr3	186839116	-
96545	GBM	TCGA-06-5415	UBXN7	chr3	196159197	-	RPL39L	chr3	186839116	-
96545	GBM	TCGA-06-5415	UBXN7	chr3	196159197	-	RPL39L	chr3	186845850	-
96545	GBM	TCGA-06-5415-01A	UBXN7	chr3	196159198	-	RPL39L	chr3	186845850	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	RPL39L	0.0267411758183873	0.7
ESCA	RPL39L	0.0281790881191097	0.7
BLCA	RPL39L	0.0292761976618958	0.7
HNSC	RPL39L	7.83632820472855e-06	0.00021
KIRC	RPL39L	8.69845867484102e-08	2.4e-06

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	RPL39L	1.52356628132539e-05	0.00049
STAD	RPL39L	0.015511879014873	0.4
LUAD	RPL39L	0.00217606084069971	0.065
LUSC	RPL39L	0.032180285133979	0.77
LGG	RPL39L	0.010709417494969	0.31
UCEC	RPL39L	0.0118256264928361	0.33
ESCA	RPL39L	1.41555942699007e-05	0.00047
PCPG	RPL39L	0.0133130442945183	0.36
THYM	RPL39L	0.00185177774744469	0.057
COAD	RPL39L	0.0183442629660379	0.46

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source