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Translation Factor: MRPL10 (NCBI Gene ID:124995) |
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 Gene Summary |
| Gene Information | Gene Name: MRPL10 | Gene ID: 124995 | Gene Symbol | MRPL10 | Gene ID | 124995 |
| Gene Name | mitochondrial ribosomal protein L10 | |
| Synonyms | L10MT|MRP-L10|MRP-L8|MRPL8|RPML8 | |
| Cytomap | 17q21.32 | |
| Type of Gene | protein-coding | |
| Description | 39S ribosomal protein L10, mitochondrial39S ribosomal protein L8, mitochondrialL8mtmitochondrial large ribosomal subunit protein uL10m | |
| Modification date | 20200313 | |
| UniProtAcc | Q7Z7H8 | |
| Child GO biological process term(s) under GO:0006412 |
| GO ID | GO term |
| GO:0005840 | Ribosome |
| GO:0006412 | Translation |
| Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Inferred gene age of translation factor. |
| Gene | Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25 |
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| We searched PubMed using 'MRPL10[title] AND translation [title] AND human.' |
| Gene | Title | PMID |
| MRPL10 | . | . |
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| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. For more annotations, please visit our ExonSkipDB. |
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| Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | ORF |
| ENST00000351111 | 45904002 | 45904147 | Frame-shift |
| Exon skipping position in the amino acid sequence. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | Len(transcript seq) | Exon skip start (mRNA) | Exon Skip end (mRNA) | Len(amino acid seq) | Exon skip start (AA) | Exon Skip end (AA) |
| Potentially (partially) lost protein functional features of UniProt. |
| UniProtAcc | Exon skip start (AA) | Exon Skip end (AA) | Function feature start (AA) | Function feature end (AA) | Functional feature type | Functional feature desc. |
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| Gene expression level across TCGA pancancer |
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| Gene expression level across GTEx pantissue |
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| Expression level of gene isoforms across TCGA pancancer |
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| Expression level of gene isoforms across GTEx pantissue |
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| Cancer(tissue) type-specific expression level of Translation factor using z-score distriution |
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| Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples) |
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| Cancer type | Translation factor | FC | adj.pval |
| LIHC | MRPL10 | -3.22703617995931 | 0.000209845686767642 |
| STAD | MRPL10 | -4.87461667395871 | 0.0118026207201183 |
| LUSC | MRPL10 | -2.440715746941 | 1.79996309233889e-05 |
| LUAD | MRPL10 | -5.60579373211551 | 4.11637918366747e-07 |
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| Translation factor expression regulation through miRNA binding |
| Cancer type | Gene | miRNA | TargetScan binding score (Context++ score percentile) | Coefficient | Pvalue |
| Translation factor expression regulation through methylation in the promoter of Translation factor |
| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation) |
| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through copy number variation of Translation factor |
| Cancer type | Gene | Coefficient | Pvalue |
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| Strongly correlated genes belong to cellular important gene groups with MRPL10 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green) |
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| Cancer type | Gene group | Translation factor | Correlated gene | Coefficient | Pvalue |
| CHOL | Cell metabolism gene | MRPL10 | NME2 | 0.812294162 | 1.26E-11 |
| CHOL | TF | MRPL10 | NME2 | 0.812294162 | 1.26E-11 |
| TGCT | TSG | MRPL10 | PHB | 0.829650922 | 8.00E-41 |
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| Protein 3D structure Visit iCn3D. |
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| Protein-protein interaction networks * Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
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| Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
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 * Edge colors based on TCGA cancer types. |
| * Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P)) |
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| Cancer type | Translation factor | Interacting protein coding gene | FC | adj.pval |
| LUSC | MRPL10 | MRPL53 | -7.51258875763857 | 0.000291380503797954 |
| KIRC | MRPL10 | MRPL55 | -1.02163441832258 | 0.000291940846845375 |
| KIRC | MRPL10 | MRPL11 | -1.04966837625557 | 0.000354478033746394 |
| LIHC | MRPL10 | MRPL13 | 1.54402472107614 | 0.000655351190157038 |
| LUSC | MRPL10 | MRPL39 | -3.50411737429004 | 0.000985010025625636 |
| CHOL | MRPL10 | MRPL3 | -2.68429255990621 | 0.00390625 |
| BLCA | MRPL10 | MRPL39 | 1.69896851960452 | 0.00391769409179688 |
| LUAD | MRPL10 | MRPL39 | -1.1049452981592 | 0.00471395891927286 |
| ESCA | MRPL10 | MRPL3 | -4.97897094908275 | 0.0048828125 |
| LUAD | MRPL10 | MRPL53 | -2.94709001291011 | 0.00627510264512955 |
| ESCA | MRPL10 | MRPL13 | -1.07746088474995 | 0.0068359375 |
| PRAD | MRPL10 | ICT1 | -1.54848444909352 | 0.00907723161841939 |
| ESCA | MRPL10 | MRPL12 | -1.00174970895481 | 0.009765625 |
| CHOL | MRPL10 | MRPL12 | -3.63130566135659 | 0.01171875 |
| STAD | MRPL10 | MRPL12 | -2.48538214070711 | 0.020511694252491 |
| STAD | MRPL10 | MRPL4 | 1.4393539135682 | 0.0279771662317216 |
| COAD | MRPL10 | MRPL39 | -1.15285953291756 | 0.0357243716716767 |
| STAD | MRPL10 | MRPL53 | 1.66304360300706 | 0.0413399673998356 |
| BLCA | MRPL10 | MRPL22 | -2.25969747792543 | 0.0493659973144531 |
| BRCA | MRPL10 | MRPL22 | -2.3061823226724 | 1.15724909394453e-08 |
| PRAD | MRPL10 | MRPL11 | 1.12581653394628 | 1.15996224044503e-05 |
| LUAD | MRPL10 | MRPL12 | -3.43280900900763 | 1.96929418449732e-09 |
| KIRC | MRPL10 | MRPL3 | 1.69955762234244 | 1.97132191719422e-08 |
| BRCA | MRPL10 | ICT1 | -4.17488220449664 | 2.73719348917167e-14 |
| COAD | MRPL10 | MRPL4 | 2.77705897514473 | 2.98023223876954e-07 |
| LIHC | MRPL10 | MRPL39 | -1.65461683386216 | 3.95799979560965e-08 |
| BRCA | MRPL10 | MRPL55 | -1.64092910603924 | 6.01408870059924e-14 |
| LUSC | MRPL10 | ICT1 | -3.23093376049456 | 6.60526357089358e-07 |
| LUAD | MRPL10 | MRPL22 | -3.64343361732659 | 6.84976461567817e-06 |
| LUSC | MRPL10 | MRPL55 | -1.42665529836846 | 7.19742900589893e-05 |
| LUAD | MRPL10 | MRPL55 | -2.50406829694459 | 7.3663238952828e-06 |
| Protein-protein interactors with this translation factor (BIOGRID-3.4.160) |
| PPI interactors with MRPL10 |
| USP22, ICT1, APP, MRPL12, MRPL15, MRPL3, MRPL13, MRPL1, MRPL11, MRPL41, MRPL23, ILF3, ABCB7, SLC25A3, ABCC2, HNRNPU, BCS1L, NPM1, REL, TCF4, PNMA1, KLHL12, FAM9B, EGFR, RPS8, MRPL4, HNRNPA1, MRPL39, MRPS30, MRPL47, MRPL22, MRPL50, MRPL9, ACTN2, MRPL42, MRPL45, MRPL2, MRPL51, MRPL55, MRPL44, MRPL34, MRPL30, MRPL49, MRPL32, MRPL16, MRPL27, MRPL17, MRPL40, MRPL28, MRPL48, MRPL38, GADD45GIP1, MRPL24, MRPS18A, MRPL33, MRPL35, MRPL19, MRPL46, MRPL20, MALSU1, MRPL43, MRPL57, MRPL18, UQCC1, MRPL53, MRPL21, MRPL14, ZZEF1, C4BPB, FGF8, RPL36AL, PREPL, LEO1, MRPL36, MRPS11, MRPS14, MRPS5, GATB, PGK1, PSMD12, TAZ, WDR61, ZNF830, ESR2, LARP7, RECQL4, SERBP1, MRM1, HSPD1, PDK1, TRMT61B, AURKAIP1, VCP, RC3H2, SNRNP70, Dppa3, PRKCI, RASA1, IMMP2L, GRSF1, ARHGAP31, ECT2L, ACAD9, AUH, C12orf65, C1QBP, C21orf33, C6orf203, CS, GFM1, GFM2, HINT2, LRPPRC, MDH2, METTL15, METTL17, MRPS12, MRPS26, MRRF, MTERF3, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, SLIRP, TACO1, TBRG4, TFAM, TRUB2, TSFM, TUFM, VWA8, EXD2, CLPP, Apc2, NR3C1, HSCB, UFL1, DDRGK1, AARS2, COX8A, PDHA1, SRSF3, ZNF483, RBMS2, LIN28A, YBX2, RPL13, RPL37, RPL19, YBX1, RPL6, H1FNT, MRPL52, RPL10, YARS2, HERC2, HIST1H2AE, RNMTL1, MRPL37, KLHL22, NEURL4, NEIL1, LONP1, RBPMS, Pcbp1, M, KLF15, |
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| Clinically associated variants from ClinVar. |
| Gene | Chr | Position | RefSeq | VarSeq | RefSeeq | VarType | Pathogenic | Disease | VarInfo |
| nsSNVs with sample frequency (size of circle) from TCGA 33 cancers. |
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| SNVs and Indels |
| Gene | Cancer type | Chromosome | Start | End | RefSeeq | MutSeq | Mutation type | AAchange | # samples |
| Copy number variation (CNV) of MRPL10 * Click on the image to open the original image in a new window. |
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| Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL10 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion genes with this translation factor from FusionGDB2.0. |
| FusionGDB2 ID | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 89826 | BLCA | TCGA-HQ-A2OF-01A | MRPL10 | chr17 | 45904003 | - | MTPAP | chr10 | 30611546 | - |
| 87218 | N/A | CS190707 | MRPL10 | chr17 | 45905895 | + | PDSS2 | chr6 | 107679553 | + |
| 89357 | N/A | ES316348 | MRPL10 | chr17 | 45900877 | - | PLP1 | chrX | 103045970 | + |
| 92287 | UCEC | TCGA-AJ-A23N-01A | MRPL10 | chr17 | 45904003 | - | SKAP1 | chr17 | 46266862 | - |
| 76259 | N/A | BE265135 | RPL23 | chr17 | 37006343 | - | MRPL10 | chr17 | 45908870 | - |
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| Kaplan-Meier plots with logrank tests of overall survival (OS) |
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| Cancer type | Translation factor | Coefficent | Hazard ratio | Wald test pval | Likelihool ratio pval | Logrank test pval | # samples |
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| Differential gene expression between female and male. (Wilcoxon test, pval<0.05) |
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| Cancer type | Translation factor | pval | adj.p |
| HNSC | MRPL10 | 0.00161752749424953 | 0.044 |
| LIHC | MRPL10 | 0.00644981348883298 | 0.17 |
| BRCA | MRPL10 | 0.0455376782275547 | 1 |
| SARC | MRPL10 | 2.09119174675967e-06 | 5.9e-05 |
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| Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05) |
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| Cancer type | Translation factor | pval | adj.p |
| LUSC | MRPL10 | 0.0163103790821265 | 0.52 |
| THCA | MRPL10 | 0.0131717287164619 | 0.43 |
| KIRP | MRPL10 | 0.0494966326408977 | 1 |
| BRCA | MRPL10 | 0.048908132131617 | 1 |
| CHOL | MRPL10 | 0.0209279920616939 | 0.65 |
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| Drugs targeting genes involved in this translation factor. (DrugBank Version 5.1.8 2021-05-08) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| Diseases associated with this translation factor. (DisGeNet 4.0) |
| Disease ID | Disease Name | # PubMeds | Disease source |
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