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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: CPEB2 (NCBI Gene ID:132864)

Gene Summary

Gene Summary

Gene Information	Gene Name: CPEB2
	Gene ID: 132864
	Gene Symbol	CPEB2
	Gene ID	132864
	Gene Name	cytoplasmic polyadenylation element binding protein 2
	Synonyms	CPE-BP2\|CPEB-2\|hCPEB-2
	Cytomap	4p15.32
	Type of Gene	protein-coding
	Description	cytoplasmic polyadenylation element-binding protein 2CPE-binding protein 2
	Modification date	20200313
	UniProtAcc	Q7Z5Q1

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0006414	Translational elongation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CPEB2	GO:0032869	cellular response to insulin stimulus	18752464
Hgene	CPEB2	GO:0071456	cellular response to hypoxia	18752464

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
CPEB2	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'CPEB2[title] AND translation [title] AND human.'

Gene	Title	PMID
CPEB2	CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis	32295602

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
ESCA	CPEB2	-7.48669309123719	0.0009765625
LIHC	CPEB2	-1.34250521086129	0.0131053846460223
CHOL	CPEB2	-2.13718122381461	0.01953125
KICH	CPEB2	1.185374553917	5.96046447753906e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
OV	CPEB2	hsa-miR-143-3p	86	-0.359181234207023	0.0089219418050735

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
BLCA	CPEB2	-0.042715975	0.02077252
KICH	CPEB2	0.02125362	0.039770886

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with CPEB2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	CPEB2	NCOA6	0.80900189	3.47E-12
DLBC	Cell metabolism gene	CPEB2	PIK3C2A	0.814841313	1.82E-12
DLBC	Cell metabolism gene	CPEB2	PIKFYVE	0.824220935	6.12E-13
DLBC	Cell metabolism gene	CPEB2	GALNT10	0.833675424	1.91E-13
DLBC	CGC	CPEB2	MAML2	0.802883147	6.68E-12
DLBC	CGC	CPEB2	KLF6	0.81879203	1.16E-12
DLBC	CGC	CPEB2	LATS2	0.823851299	6.40E-13
DLBC	CGC	CPEB2	ZEB1	0.84388521	5.01E-14
DLBC	Epifactor	CPEB2	NCOA6	0.80900189	3.47E-12
DLBC	Epifactor	CPEB2	CDK17	0.812390329	2.39E-12
DLBC	Epifactor	CPEB2	HCFC2	0.81624587	1.55E-12
DLBC	IUPHAR	CPEB2	CDK17	0.812390329	2.39E-12
DLBC	IUPHAR	CPEB2	SLC10A7	0.813481751	2.12E-12
DLBC	IUPHAR	CPEB2	SLC30A7	0.813784427	2.05E-12
DLBC	IUPHAR	CPEB2	PIK3C2A	0.814841313	1.82E-12
DLBC	IUPHAR	CPEB2	LATS2	0.823851299	6.40E-13
DLBC	IUPHAR	CPEB2	PIKFYVE	0.824220935	6.12E-13
DLBC	Kinase	CPEB2	CDK17	0.812390329	2.39E-12
DLBC	Kinase	CPEB2	LATS2	0.823851299	6.40E-13
DLBC	TF	CPEB2	ZNF136	0.800512527	8.55E-12
DLBC	TF	CPEB2	KLF6	0.81879203	1.16E-12
DLBC	TF	CPEB2	ZEB2	0.819749578	1.04E-12
DLBC	TF	CPEB2	ZEB1	0.84388521	5.01E-14
DLBC	TSG	CPEB2	TRIM35	0.803583893	6.20E-12
DLBC	TSG	CPEB2	KIF1B	0.805565019	5.03E-12
DLBC	TSG	CPEB2	KLF6	0.81879203	1.16E-12
DLBC	TSG	CPEB2	LATS2	0.823851299	6.40E-13
THYM	Cell metabolism gene	CPEB2	RRM2B	0.819623463	8.24E-31
THYM	Cell metabolism gene	CPEB2	CLOCK	0.823512914	2.52E-31
THYM	CGC	CPEB2	CLIP1	0.884943934	1.22E-41
THYM	Epifactor	CPEB2	ASH1L	0.807938281	2.45E-29
THYM	Epifactor	CPEB2	CLOCK	0.823512914	2.52E-31
THYM	IUPHAR	CPEB2	CLCN3	0.804957859	5.62E-29
THYM	IUPHAR	CPEB2	HIPK2	0.806425926	3.74E-29
THYM	IUPHAR	CPEB2	ASH1L	0.807938281	2.45E-29
THYM	IUPHAR	CPEB2	NIPAL2	0.81362097	4.85E-30
THYM	IUPHAR	CPEB2	RRM2B	0.819623463	8.24E-31
THYM	IUPHAR	CPEB2	CLOCK	0.823512914	2.52E-31
THYM	Kinase	CPEB2	HIPK2	0.806425926	3.74E-29
THYM	TF	CPEB2	ASH1L	0.807938281	2.45E-29
THYM	TF	CPEB2	CLOCK	0.823512914	2.52E-31
THYM	TF	CPEB2	SKIL	0.842815154	4.44E-34
THYM	TF	CPEB2	EEA1	0.86233145	2.87E-37
THYM	TSG	CPEB2	HIPK2	0.806425926	3.74E-29
THYM	TSG	CPEB2	SKIL	0.842815154	4.44E-34
UCS	Cell metabolism gene	CPEB2	RRM2B	0.819623463	8.24E-31
UCS	Cell metabolism gene	CPEB2	CLOCK	0.823512914	2.52E-31
UCS	CGC	CPEB2	CLIP1	0.884943934	1.22E-41
UCS	Epifactor	CPEB2	ASH1L	0.807938281	2.45E-29
UCS	Epifactor	CPEB2	CLOCK	0.823512914	2.52E-31
UCS	IUPHAR	CPEB2	CLCN3	0.804957859	5.62E-29
UCS	IUPHAR	CPEB2	HIPK2	0.806425926	3.74E-29
UCS	IUPHAR	CPEB2	ASH1L	0.807938281	2.45E-29
UCS	IUPHAR	CPEB2	NIPAL2	0.81362097	4.85E-30
UCS	IUPHAR	CPEB2	RRM2B	0.819623463	8.24E-31
UCS	IUPHAR	CPEB2	CLOCK	0.823512914	2.52E-31
UCS	Kinase	CPEB2	HIPK2	0.806425926	3.74E-29
UCS	TF	CPEB2	ASH1L	0.807938281	2.45E-29
UCS	TF	CPEB2	CLOCK	0.823512914	2.52E-31
UCS	TF	CPEB2	SKIL	0.842815154	4.44E-34
UCS	TF	CPEB2	EEA1	0.86233145	2.87E-37
UCS	TSG	CPEB2	HIPK2	0.806425926	3.74E-29
UCS	TSG	CPEB2	SKIL	0.842815154	4.44E-34
UVM	Cell metabolism gene	CPEB2	GNAQ	0.800860632	4.77E-19
UVM	Cell metabolism gene	CPEB2	MTMR6	0.802342785	3.68E-19
UVM	Cell metabolism gene	CPEB2	MED17	0.803218095	3.15E-19
UVM	Cell metabolism gene	CPEB2	MTR	0.804110321	2.69E-19
UVM	Cell metabolism gene	CPEB2	ACSL4	0.804587418	2.47E-19
UVM	Cell metabolism gene	CPEB2	SACM1L	0.806230527	1.83E-19
UVM	Cell metabolism gene	CPEB2	PSMC6	0.8102234	8.83E-20
UVM	Cell metabolism gene	CPEB2	XPO1	0.811541215	6.91E-20
UVM	Cell metabolism gene	CPEB2	RANBP2	0.81181689	6.57E-20
UVM	Cell metabolism gene	CPEB2	FBXL3	0.814942973	3.64E-20
UVM	Cell metabolism gene	CPEB2	ALG13	0.815193357	3.47E-20
UVM	Cell metabolism gene	CPEB2	DCK	0.819667932	1.46E-20
UVM	Cell metabolism gene	CPEB2	MANEA	0.825932449	4.18E-21
UVM	Cell metabolism gene	CPEB2	PIKFYVE	0.827365035	3.12E-21
UVM	Cell metabolism gene	CPEB2	PRKAA1	0.827440941	3.07E-21
UVM	Cell metabolism gene	CPEB2	SLC19A2	0.832816234	9.95E-22
UVM	Cell metabolism gene	CPEB2	GXYLT1	0.852814704	1.03E-23
UVM	Cell metabolism gene	CPEB2	PPP1CB	0.857370796	3.32E-24
UVM	Cell metabolism gene	CPEB2	FAR1	0.858799185	2.30E-24
UVM	Cell metabolism gene	CPEB2	GNPDA2	0.860761711	1.39E-24
UVM	Cell metabolism gene	CPEB2	ALG10B	0.864770602	4.81E-25
UVM	Cell metabolism gene	CPEB2	ETNK1	0.868144473	1.92E-25
UVM	CGC	CPEB2	GNAQ	0.800860632	4.77E-19
UVM	CGC	CPEB2	RGPD3	0.807383654	1.49E-19
UVM	CGC	CPEB2	XPO1	0.811541215	6.91E-20
UVM	CGC	CPEB2	RANBP2	0.81181689	6.57E-20
UVM	CGC	CPEB2	CDC73	0.813375499	4.90E-20
UVM	CGC	CPEB2	DICER1	0.814238151	4.16E-20
UVM	CGC	CPEB2	SMAD4	0.818613593	1.80E-20
UVM	CGC	CPEB2	MLLT10	0.820621344	1.21E-20
UVM	CGC	CPEB2	KRAS	0.821680795	9.83E-21
UVM	CGC	CPEB2	SUZ12	0.822328376	8.64E-21
UVM	CGC	CPEB2	PHF6	0.825896934	4.21E-21
UVM	CGC	CPEB2	ARID2	0.833930912	7.84E-22
UVM	CGC	CPEB2	ATRX	0.835242375	5.91E-22
UVM	CGC	CPEB2	KIF5B	0.837208518	3.85E-22
UVM	CGC	CPEB2	FBXO11	0.838509559	2.89E-22
UVM	CGC	CPEB2	BMPR1A	0.848569044	2.88E-23
UVM	CGC	CPEB2	PMS1	0.848803151	2.72E-23
UVM	CGC	CPEB2	SF3B1	0.851507009	1.42E-23
UVM	CGC	CPEB2	TET2	0.852567998	1.10E-23
UVM	CGC	CPEB2	CREB1	0.854399751	6.98E-24
UVM	CGC	CPEB2	STAG2	0.85796185	2.85E-24
UVM	CGC	CPEB2	ETNK1	0.868144473	1.92E-25
UVM	Epifactor	CPEB2	HCFC2	0.801203585	4.49E-19
UVM	Epifactor	CPEB2	SMEK1	0.802682697	3.46E-19
UVM	Epifactor	CPEB2	EID1	0.805446954	2.11E-19
UVM	Epifactor	CPEB2	BRWD1	0.806039015	1.90E-19
UVM	Epifactor	CPEB2	NIPBL	0.806222521	1.84E-19
UVM	Epifactor	CPEB2	USP15	0.806917989	1.62E-19
UVM	Epifactor	CPEB2	CDC73	0.813375499	4.90E-20
UVM	Epifactor	CPEB2	SMARCAD1	0.815616439	3.20E-20
UVM	Epifactor	CPEB2	ZMYND11	0.818085823	1.99E-20
UVM	Epifactor	CPEB2	CUL4B	0.819351413	1.55E-20
UVM	Epifactor	CPEB2	MLLT10	0.820621344	1.21E-20
UVM	Epifactor	CPEB2	AEBP2	0.822086869	9.06E-21
UVM	Epifactor	CPEB2	SUZ12	0.822328376	8.64E-21
UVM	Epifactor	CPEB2	RMI1	0.822373142	8.56E-21
UVM	Epifactor	CPEB2	CDK17	0.824485879	5.60E-21
UVM	Epifactor	CPEB2	PHIP	0.825669783	4.41E-21
UVM	Epifactor	CPEB2	SIRT1	0.82611024	4.03E-21
UVM	Epifactor	CPEB2	ARID4B	0.827245615	3.19E-21
UVM	Epifactor	CPEB2	PRKAA1	0.827440941	3.07E-21
UVM	Epifactor	CPEB2	PCGF6	0.827496838	3.03E-21
UVM	Epifactor	CPEB2	CUL2	0.831043222	1.45E-21
UVM	Epifactor	CPEB2	HMGB1	0.832591285	1.04E-21
UVM	Epifactor	CPEB2	CHD1	0.832945845	9.68E-22
UVM	Epifactor	CPEB2	EPC2	0.833054388	9.46E-22
UVM	Epifactor	CPEB2	PCGF3	0.833421107	8.74E-22
UVM	Epifactor	CPEB2	ARID2	0.833930912	7.84E-22
UVM	Epifactor	CPEB2	ATRX	0.835242375	5.91E-22
UVM	Epifactor	CPEB2	CHD9	0.836151523	4.85E-22
UVM	Epifactor	CPEB2	BAZ2B	0.838286859	3.03E-22
UVM	Epifactor	CPEB2	YEATS4	0.838786571	2.72E-22
UVM	Epifactor	CPEB2	UHRF2	0.840867036	1.71E-22
UVM	Epifactor	CPEB2	CUL5	0.845754947	5.57E-23
UVM	Epifactor	CPEB2	MBTD1	0.846729463	4.44E-23
UVM	Epifactor	CPEB2	RCOR3	0.848400871	2.99E-23
UVM	Epifactor	CPEB2	SF3B1	0.851507009	1.42E-23
UVM	Epifactor	CPEB2	OGT	0.851728382	1.35E-23
UVM	Epifactor	CPEB2	TET2	0.852567998	1.10E-23
UVM	Epifactor	CPEB2	ARID4A	0.85383723	8.03E-24
UVM	Epifactor	CPEB2	INO80D	0.855746952	4.99E-24
UVM	Epifactor	CPEB2	SMEK2	0.858168204	2.71E-24
UVM	Epifactor	CPEB2	JMJD1C	0.863007488	7.69E-25
UVM	Epifactor	CPEB2	RLIM	0.868490614	1.74E-25
UVM	Epifactor	CPEB2	ATAD2B	0.871908308	6.68E-26
UVM	IUPHAR	CPEB2	ATP6V0A2	0.800217378	5.34E-19
UVM	IUPHAR	CPEB2	TBK1	0.800348284	5.22E-19
UVM	IUPHAR	CPEB2	GNAQ	0.800860632	4.77E-19
UVM	IUPHAR	CPEB2	SLC30A9	0.801288878	4.43E-19
UVM	IUPHAR	CPEB2	TNKS2	0.802378281	3.65E-19
UVM	IUPHAR	CPEB2	PKN2	0.802910672	3.32E-19
UVM	IUPHAR	CPEB2	PRPF4B	0.803229321	3.14E-19
UVM	IUPHAR	CPEB2	MTR	0.804110321	2.69E-19
UVM	IUPHAR	CPEB2	BRWD1	0.806039015	1.90E-19
UVM	IUPHAR	CPEB2	NEK1	0.809364055	1.04E-19
UVM	IUPHAR	CPEB2	XPO1	0.811541215	6.91E-20
UVM	IUPHAR	CPEB2	SLK	0.816215708	2.85E-20
UVM	IUPHAR	CPEB2	RIOK3	0.81646072	2.72E-20
UVM	IUPHAR	CPEB2	BIRC2	0.817606057	2.18E-20
UVM	IUPHAR	CPEB2	ZMYND11	0.818085823	1.99E-20
UVM	IUPHAR	CPEB2	KRAS	0.821680795	9.83E-21
UVM	IUPHAR	CPEB2	CDK17	0.824485879	5.60E-21
UVM	IUPHAR	CPEB2	CSNK1G3	0.825214847	4.83E-21
UVM	IUPHAR	CPEB2	PHIP	0.825669783	4.41E-21
UVM	IUPHAR	CPEB2	SIRT1	0.82611024	4.03E-21
UVM	IUPHAR	CPEB2	BMPR2	0.826380168	3.81E-21
UVM	IUPHAR	CPEB2	PIKFYVE	0.827365035	3.12E-21
UVM	IUPHAR	CPEB2	PRKAA1	0.827440941	3.07E-21
UVM	IUPHAR	CPEB2	TRPM7	0.832449332	1.08E-21
UVM	IUPHAR	CPEB2	SLC19A2	0.832816234	9.95E-22
UVM	IUPHAR	CPEB2	XIAP	0.833943115	7.82E-22
UVM	IUPHAR	CPEB2	NEK7	0.836655822	4.34E-22
UVM	IUPHAR	CPEB2	BAZ2B	0.838286859	3.03E-22
UVM	IUPHAR	CPEB2	FBXO11	0.838509559	2.89E-22
UVM	IUPHAR	CPEB2	CLK4	0.844660285	7.18E-23
UVM	IUPHAR	CPEB2	NR3C1	0.845488344	5.93E-23
UVM	IUPHAR	CPEB2	BMPR1A	0.848569044	2.88E-23
UVM	IUPHAR	CPEB2	MAP4K3	0.857354291	3.33E-24
UVM	IUPHAR	CPEB2	CLK1	0.860177096	1.62E-24
UVM	IUPHAR	CPEB2	JMJD1C	0.863007488	7.69E-25
UVM	IUPHAR	CPEB2	ATAD2B	0.871908308	6.68E-26
UVM	Kinase	CPEB2	TBK1	0.800348284	5.22E-19
UVM	Kinase	CPEB2	PKN2	0.802910672	3.32E-19
UVM	Kinase	CPEB2	PRPF4B	0.803229321	3.14E-19
UVM	Kinase	CPEB2	NEK1	0.809364055	1.04E-19
UVM	Kinase	CPEB2	PAN3	0.809990638	9.22E-20
UVM	Kinase	CPEB2	SLK	0.816215708	2.85E-20
UVM	Kinase	CPEB2	RIOK3	0.81646072	2.72E-20
UVM	Kinase	CPEB2	CDK17	0.824485879	5.60E-21
UVM	Kinase	CPEB2	CSNK1G3	0.825214847	4.83E-21
UVM	Kinase	CPEB2	BMPR2	0.826380168	3.81E-21
UVM	Kinase	CPEB2	PRKAA1	0.827440941	3.07E-21
UVM	Kinase	CPEB2	TRPM7	0.832449332	1.08E-21
UVM	Kinase	CPEB2	NEK7	0.836655822	4.34E-22
UVM	Kinase	CPEB2	CLK4	0.844660285	7.18E-23
UVM	Kinase	CPEB2	BMPR1A	0.848569044	2.88E-23
UVM	Kinase	CPEB2	MAP4K3	0.857354291	3.33E-24
UVM	Kinase	CPEB2	CLK1	0.860177096	1.62E-24
UVM	TF	CPEB2	ZNF320	0.800027224	5.52E-19
UVM	TF	CPEB2	ZNF224	0.800279997	5.28E-19
UVM	TF	CPEB2	ZNF280C	0.800518945	5.07E-19
UVM	TF	CPEB2	ZNF236	0.800596588	5.00E-19
UVM	TF	CPEB2	ZNF267	0.801015886	4.64E-19
UVM	TF	CPEB2	AHCTF1	0.801646512	4.16E-19
UVM	TF	CPEB2	RBAK	0.802004402	3.90E-19
UVM	TF	CPEB2	ZNF189	0.802443253	3.61E-19
UVM	TF	CPEB2	ZNF266	0.803163723	3.18E-19
UVM	TF	CPEB2	ZNF470	0.803573852	2.95E-19
UVM	TF	CPEB2	ZNF585B	0.803939886	2.77E-19
UVM	TF	CPEB2	ZNF100	0.805225052	2.20E-19
UVM	TF	CPEB2	ZNF14	0.805238137	2.19E-19
UVM	TF	CPEB2	ZNF268	0.805611525	2.05E-19
UVM	TF	CPEB2	GABPA	0.805648637	2.04E-19
UVM	TF	CPEB2	ZNF234	0.8061684	1.85E-19
UVM	TF	CPEB2	ZNF529	0.80639702	1.78E-19
UVM	TF	CPEB2	ZNF354B	0.806716037	1.68E-19
UVM	TF	CPEB2	ZNF148	0.808657983	1.18E-19
UVM	TF	CPEB2	JRKL	0.80925115	1.06E-19
UVM	TF	CPEB2	ZNF680	0.809404173	1.03E-19
UVM	TF	CPEB2	ZBTB6	0.809675392	9.77E-20
UVM	TF	CPEB2	ZNF143	0.809760042	9.62E-20
UVM	TF	CPEB2	TMF1	0.809767988	9.61E-20
UVM	TF	CPEB2	MEF2A	0.809875124	9.42E-20
UVM	TF	CPEB2	ZNF28	0.809901357	9.38E-20
UVM	TF	CPEB2	ZFP14	0.809928808	9.33E-20
UVM	TF	CPEB2	ZNF26	0.811018244	7.62E-20
UVM	TF	CPEB2	ZNF493	0.813166195	5.10E-20
UVM	TF	CPEB2	ZNF845	0.814747257	3.78E-20
UVM	TF	CPEB2	ZNF761	0.817058544	2.43E-20
UVM	TF	CPEB2	ZNF195	0.817438422	2.26E-20
UVM	TF	CPEB2	FOXN2	0.817906684	2.06E-20
UVM	TF	CPEB2	SMAD4	0.818613593	1.80E-20
UVM	TF	CPEB2	ZNF624	0.820172731	1.32E-20
UVM	TF	CPEB2	ZMAT1	0.82027164	1.30E-20
UVM	TF	CPEB2	ZNF200	0.821706931	9.77E-21
UVM	TF	CPEB2	AEBP2	0.822086869	9.06E-21
UVM	TF	CPEB2	ZBED5	0.82218032	8.90E-21
UVM	TF	CPEB2	TOPORS	0.82228969	8.71E-21
UVM	TF	CPEB2	ZNF546	0.822571939	8.23E-21
UVM	TF	CPEB2	ZNF701	0.822655892	8.09E-21
UVM	TF	CPEB2	ZNF451	0.823624013	6.67E-21
UVM	TF	CPEB2	ZBTB44	0.824096745	6.06E-21
UVM	TF	CPEB2	ZNF226	0.824207508	5.93E-21
UVM	TF	CPEB2	ZNF800	0.824346815	5.76E-21
UVM	TF	CPEB2	NFXL1	0.824770886	5.29E-21
UVM	TF	CPEB2	ZNF260	0.824779892	5.28E-21
UVM	TF	CPEB2	ZNF254	0.825722251	4.36E-21
UVM	TF	CPEB2	SP3	0.826258626	3.91E-21
UVM	TF	CPEB2	ZNF10	0.82667539	3.59E-21
UVM	TF	CPEB2	ZNF674	0.826981737	3.37E-21
UVM	TF	CPEB2	PCGF6	0.827496838	3.03E-21
UVM	TF	CPEB2	ZNF432	0.827711447	2.90E-21
UVM	TF	CPEB2	ZNF567	0.828599793	2.41E-21
UVM	TF	CPEB2	PRDM10	0.828641615	2.39E-21
UVM	TF	CPEB2	ZNF700	0.829017755	2.21E-21
UVM	TF	CPEB2	ZNF33A	0.829410131	2.04E-21
UVM	TF	CPEB2	ZNF527	0.830444529	1.64E-21
UVM	TF	CPEB2	ZNF12	0.83045937	1.64E-21
UVM	TF	CPEB2	ZNF780A	0.83136177	1.35E-21
UVM	TF	CPEB2	ZNF721	0.83152673	1.31E-21
UVM	TF	CPEB2	ZNF780B	0.833522066	8.56E-22
UVM	TF	CPEB2	ARID2	0.833930912	7.84E-22
UVM	TF	CPEB2	ZNF75D	0.834378969	7.12E-22
UVM	TF	CPEB2	ZNF140	0.835993504	5.02E-22
UVM	TF	CPEB2	ZFX	0.836968402	4.06E-22
UVM	TF	CPEB2	ZNF136	0.837601678	3.53E-22
UVM	TF	CPEB2	BAZ2B	0.838286859	3.03E-22
UVM	TF	CPEB2	ZNF658	0.839198406	2.48E-22
UVM	TF	CPEB2	ELF2	0.839414542	2.36E-22
UVM	TF	CPEB2	ZNF606	0.839431451	2.35E-22
UVM	TF	CPEB2	ZNF302	0.840250568	1.96E-22
UVM	TF	CPEB2	ZNF182	0.842401862	1.21E-22
UVM	TF	CPEB2	ZNF181	0.843282123	9.86E-23
UVM	TF	CPEB2	ZNF25	0.843770335	8.82E-23
UVM	TF	CPEB2	ZNF180	0.843842137	8.68E-23
UVM	TF	CPEB2	THAP9	0.843961151	8.44E-23
UVM	TF	CPEB2	ZNF280D	0.844503963	7.45E-23
UVM	TF	CPEB2	ZNF441	0.844780872	6.99E-23
UVM	TF	CPEB2	ZBTB41	0.844839331	6.89E-23
UVM	TF	CPEB2	NR3C1	0.845488344	5.93E-23
UVM	TF	CPEB2	ZNF566	0.846176489	5.05E-23
UVM	TF	CPEB2	SMAD5	0.846628451	4.55E-23
UVM	TF	CPEB2	LIN54	0.847457187	3.74E-23
UVM	TF	CPEB2	ZNF43	0.848419546	2.98E-23
UVM	TF	CPEB2	THAP5	0.848638546	2.83E-23
UVM	TF	CPEB2	ZNF675	0.849192969	2.48E-23
UVM	TF	CPEB2	THAP6	0.849949584	2.07E-23
UVM	TF	CPEB2	ZBTB1	0.851458585	1.44E-23
UVM	TF	CPEB2	TET2	0.852567998	1.10E-23
UVM	TF	CPEB2	ZNF84	0.85275671	1.05E-23
UVM	TF	CPEB2	CREB1	0.854399751	6.98E-24
UVM	TF	CPEB2	ZNF141	0.856800344	3.83E-24
UVM	TF	CPEB2	DMTF1	0.857496992	3.21E-24
UVM	TF	CPEB2	IKZF5	0.857842788	2.94E-24
UVM	TF	CPEB2	EEA1	0.858205121	2.68E-24
UVM	TF	CPEB2	ZNF449	0.859782264	1.79E-24
UVM	TF	CPEB2	ZNF24	0.864637388	4.98E-25
UVM	TF	CPEB2	ZNF431	0.86589123	3.55E-25
UVM	TF	CPEB2	ZNF510	0.866678337	2.87E-25
UVM	TF	CPEB2	ZNF248	0.867251464	2.45E-25
UVM	TF	CPEB2	ZNF708	0.86803313	1.98E-25
UVM	TF	CPEB2	CREBZF	0.873426129	4.32E-26
UVM	TF	CPEB2	ZNF518A	0.881864831	3.46E-27
UVM	TSG	CPEB2	INTS6	0.804421555	2.54E-19
UVM	TSG	CPEB2	COPS2	0.805463932	2.11E-19
UVM	TSG	CPEB2	CCAR1	0.806720284	1.68E-19
UVM	TSG	CPEB2	MLH3	0.807037252	1.58E-19
UVM	TSG	CPEB2	VEZT	0.807277737	1.52E-19
UVM	TSG	CPEB2	CDC73	0.813375499	4.90E-20
UVM	TSG	CPEB2	DICER1	0.814238151	4.16E-20
UVM	TSG	CPEB2	GORAB	0.814427411	4.02E-20
UVM	TSG	CPEB2	NEDD4	0.814638535	3.86E-20
UVM	TSG	CPEB2	ZMYND11	0.818085823	1.99E-20
UVM	TSG	CPEB2	APAF1	0.818205361	1.94E-20
UVM	TSG	CPEB2	SMAD4	0.818613593	1.80E-20
UVM	TSG	CPEB2	SMCHD1	0.819084866	1.64E-20
UVM	TSG	CPEB2	KRIT1	0.821129557	1.10E-20
UVM	TSG	CPEB2	TOPORS	0.82228969	8.71E-21
UVM	TSG	CPEB2	SUZ12	0.822328376	8.64E-21
UVM	TSG	CPEB2	DCLRE1A	0.822714217	8.00E-21
UVM	TSG	CPEB2	PHF6	0.825896934	4.21E-21
UVM	TSG	CPEB2	SIRT1	0.82611024	4.03E-21
UVM	TSG	CPEB2	BMPR2	0.826380168	3.81E-21
UVM	TSG	CPEB2	PRKAA1	0.827440941	3.07E-21
UVM	TSG	CPEB2	TANK	0.829332674	2.07E-21
UVM	TSG	CPEB2	CUL2	0.831043222	1.45E-21
UVM	TSG	CPEB2	CHD1	0.832945845	9.68E-22
UVM	TSG	CPEB2	ARID2	0.833930912	7.84E-22
UVM	TSG	CPEB2	RB1CC1	0.839248618	2.45E-22
UVM	TSG	CPEB2	UHRF2	0.840867036	1.71E-22
UVM	TSG	CPEB2	CUL5	0.845754947	5.57E-23
UVM	TSG	CPEB2	BMPR1A	0.848569044	2.88E-23
UVM	TSG	CPEB2	LIN9	0.848610559	2.85E-23
UVM	TSG	CPEB2	TET2	0.852567998	1.10E-23
UVM	TSG	CPEB2	DMTF1	0.857496992	3.21E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	CPEB2	CTNNB1	1.35387002426383	0.000139892101287842
KICH	CPEB2	PKP3	1.89352426112481	0.000139892101287842
KIRP	CPEB2	CTNNB1	1.44413647030576	0.00019507110118866
HNSC	CPEB2	EEF2	-1.90805330069302	0.000299885096865183
THCA	CPEB2	EEF2	1.35574858496176	0.000711089919756285
KICH	CPEB2	FMR1	1.78310178813069	0.00102710723876953
COAD	CPEB2	EEF2	1.67025113686866	0.00197160243988037
STAD	CPEB2	EEF2	-1.87846190344448	0.00733334058895707
LUSC	CPEB2	CTNNB1	-1.53686315879634	0.00765883184752251
KIRP	CPEB2	FMR1	-1.94284822624948	0.0099095250479877
CHOL	CPEB2	PKP1	-3.09902057112593	0.01171875
UCEC	CPEB2	PKP1	-1.43579006250582	0.015625
ESCA	CPEB2	EEF2	-3.4598326417414	0.0185546875
READ	CPEB2	AURKA	2.44185876815714	0.03125
READ	CPEB2	CDK1	1.89004239599197	0.03125
READ	CPEB2	PLK1	2.49229699621777	0.03125
COAD	CPEB2	FXR2	1.01105544222868	0.0407472252845765
BLCA	CPEB2	PKP1	1.45663569275451	0.0445594787597656
BRCA	CPEB2	FMR1	-2.74053611255086	0.0481383834499222
BLCA	CPEB2	PKP3	3.7796507825186	0.0493659973144531
KIRC	CPEB2	FMR1	-2.35406916543664	1.12145348829767e-07
LIHC	CPEB2	CCNB2	-2.52392868377072	1.26395969954206e-09
HNSC	CPEB2	FMR1	-2.72606987034586	1.37760207508109e-06
KIRP	CPEB2	AURKA	-1.39611353637217	2.00234353542328e-08
KIRP	CPEB2	CCNB2	-1.18545366541394	2.00234353542328e-08
LUAD	CPEB2	PKP3	1.2887646649559	2.06445826218016e-10
COAD	CPEB2	PLK1	1.87321844191486	2.08616256713867e-07
PRAD	CPEB2	CCNB2	-1.21482461847798	2.36390621045854e-07
KIRC	CPEB2	PLK1	-1.10261987714157	2.37769366427877e-11
KICH	CPEB2	PKP1	1.26020770889859	2.5629997253418e-06
BRCA	CPEB2	PKP1	-2.38004571339973	2.68441190245168e-20
COAD	CPEB2	CCNB2	1.17232391077129	2.69412994384766e-05
PRAD	CPEB2	EEF2	1.63926479894191	2.70126293247147e-08
KIRC	CPEB2	PKP3	1.25459780293146	3.10358016139282e-10
BRCA	CPEB2	PKP3	2.0396453554909	3.16423812113157e-13
LUSC	CPEB2	PKP1	3.47380739565072	3.23227619897643e-09
KIRP	CPEB2	PLK1	-1.20762698709131	3.25962901115418e-08
KICH	CPEB2	AURKA	-5.44989541314857	5.96046447753906e-08
KIRP	CPEB2	PKP1	1.1756033395972	6.68526627123356e-05
LUSC	CPEB2	PKP3	2.0423472590436	7.13549502039471e-10
LIHC	CPEB2	PLK1	-2.42274928488654	8.27893173553169e-10
LIHC	CPEB2	CDK1	-2.27509761133223	8.79719397863617e-10
COAD	CPEB2	AURKA	2.45048892666079	8.94069671630861e-08
KIRC	CPEB2	CCNB2	-1.24795297754405	9.04004890862992e-12

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with CPEB2

Mta2, Sept7, Cul1, ATG2A, ATP6, COPS7A, EEF2, GABBR1, GAA, KEAP1, ATP1B2, NECAB2, OTUB1, PIGS, PUF60, ERI3, PSAP, SPARC, BSCL2, SEMA4B, CAPN15, SORBS3, TUBA1A, C2CD2L, HIF1A, GPX7, KIAA1429, CSK, MEX3B, KIF14, CPEB4, RBPMS, DMRTB1, TFIP11, U2AF1, USP42, Rbm14, Rbm38, U2af2, Celf1, Pcbp1, Ndel1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
CPEB2	BRCA	chr4	15054051	15054051	C	G	Silent	p.L293	4
CPEB2	UCEC	chr4	15067858	15067858	T	-	Frame_Shift_Del	p.F987fs	3
CPEB2	ESCA	chr4	15060881	15060881	G	A	Missense_Mutation	p.R884Q	3
CPEB2	COAD	chr4	15005604	15005604	G	A	Missense_Mutation	p.S436N	3
CPEB2	BRCA	chr4	15054069	15054069	C	G	Silent	p.G299	3
CPEB2	BRCA	chr4	15060048	15060048	A	G	Missense_Mutation	p.Y377C	3
CPEB2	BRCA	chr4	15067943	15067943	A	G	Missense_Mutation	p.H570R	3
CPEB2	CESC	chr4	15009019	15009019	C	T	Missense_Mutation		2
CPEB2	CESC	chr4	15009019	15009019	C	T	Missense_Mutation	p.H585Y	2
CPEB2	LIHC	chr4	15067830	15067830	C	T	Silent	p.G977G	2
CPEB2	UCEC	chr4	15009084	15009084	G	A	Silent	p.P169	2
CPEB2	ESCA	chr4	15060881	15060881	G	A	Missense_Mutation		2
CPEB2	UCEC	chr4	15009149	15009149	C	A	Missense_Mutation	p.S191Y	2
CPEB2	BLCA	chr4	15005738	15005739	-	GCG	In_Frame_Ins	p.487_488insG	2
CPEB2	UCEC	chr4	15054149	15054149	G	A	Missense_Mutation	p.R326Q	2
CPEB2	LIHC	chr4	15010032	15010032	G	A	Missense_Mutation	p.G672E	2
CPEB2	BRCA	chr4	15067831	15067831	G	A	Missense_Mutation	p.A533T	2
CPEB2	STAD	chr4	15054167	15054167	G	T	Missense_Mutation		2
CPEB2	UCEC	chr4	15054200	15054200	T	G	Missense_Mutation	p.I343S	2
CPEB2	STAD	chr4	15054167	15054167	G	T	Missense_Mutation	p.R777L	2
CPEB2	UCEC	chr4	15060051	15060051	C	T	Missense_Mutation	p.A378V	2
CPEB2	UCEC	chr4	15060121	15060121	A	T	Missense_Mutation	p.K401N	2
CPEB2	ACC	chr4	15067858	15067858	T	-	Frame_Shift_Del	p.F988fs	2
CPEB2	LIHC	chr4	15067830	15067830	C	T	Silent		2
CPEB2	COAD	chr4	15067858	15067858	T	-	Frame_Shift_Del	p.P978fs	2
CPEB2	BLCA	chr4	15063847	15063847	G	A	Missense_Mutation		1
CPEB2	HNSC	chr4	15063859	15063859	T	A	Missense_Mutation	p.L951H	1
CPEB2	SKCM	chr4	15034806	15034806	C	T	Missense_Mutation	p.P716L	1
CPEB2	UCEC	chr4	15009122	15009122	G	T	Missense_Mutation	p.R619L	1
CPEB2	CESC	chr4	15004504	15004504	C	T	Silent		1
CPEB2	LIHC	chr4	15005655	15005655	T	C	Missense_Mutation	p.L453P	1
CPEB2	STAD	chr4	15009022	15009022	C	T	Missense_Mutation	p.R586C	1
CPEB2	ESCA	chr4	15004737	15004739	CCT	-	In_Frame_Del	p.S151in_frame_del	1
CPEB2	LUAD	chr4	15067887	15067887	G	T	Missense_Mutation	p.Q996H	1
CPEB2	SARC	chr4	15067858	15067858	T	-	Frame_Shift_Del		1
CPEB2	STAD	chr4	15067820	15067820	A	G	Missense_Mutation	p.E529G	1
CPEB2	BLCA	chr4	15018869	15018869	G	T	Missense_Mutation		1
CPEB2	HNSC	chr4	15063828	15063828	A	G	Missense_Mutation	p.I941V	1
CPEB2	SKCM	chr4	15067992	15067992	C	T	Silent	p.F1031F	1
CPEB2	LIHC	chr4	15004505	15004505	G	A	Missense_Mutation	p.G70S	1
CPEB2	STAD	chr4	15055827	15055827	A	G	Missense_Mutation	p.Y816C	1
CPEB2	LUAD	chr4	15009984	15009984	C	A	Missense_Mutation	p.P656Q	1
CPEB2	SARC	chr4	15018851	15018851	T	C	Silent		1
CPEB2	STAD	chr4	15009113	15009113	A	G	Missense_Mutation	p.K179R	1
CPEB2	BLCA	chr4	15063876	15063876	G	T	Missense_Mutation		1
CPEB2	HNSC	chr4	15054114	15054114	A	G	Silent	p.S759S	1
CPEB2	SKCM	chr4	15063816	15063816	C	T	Nonsense_Mutation	p.Q937*	1
CPEB2	UCEC	chr4	15067857	15067858	-	T	Frame_Shift_Ins	p.P986fs	1
CPEB2	STAD	chr4	15067820	15067820	A	G	Missense_Mutation	p.E974G	1
CPEB2	ESCA	chr4	15063712	15063712	C	T	Missense_Mutation	p.A902V	1
CPEB2	LUAD	chr4	15009984	15009984	C	A	Missense_Mutation	p.P219Q	1
CPEB2	SKCM	chr4	15063885	15063886	-	T	Splice_Site	.	1
CPEB2	STAD	chr4	15005744	15005744	G	T	Missense_Mutation	p.G46C	1
CPEB2	BLCA	chr4	15063847	15063847	G	A	Missense_Mutation	p.R947Q	1
CPEB2	HNSC	chr4	15063786	15063786	A	G	Missense_Mutation	p.K927E	1
CPEB2	SKCM	chr4	15005738	15005739	-	GCG	In_Frame_Ins	p.480_481insA	1
CPEB2	CESC	chr4	15004504	15004504	C	T	Silent	p.L69	1
CPEB2	LIHC	chr4	15010011	15010011	A	G	Missense_Mutation	p.D665G	1
CPEB2	STAD	chr4	15054156	15054156	A	G	Silent	p.E773E	1
CPEB2	LUSC	chr4	15060838	15060838	G	C	Missense_Mutation	p.D870H	1
CPEB2	SKCM	chr4	15018896	15018897	-	T	Frame_Shift_Ins	p.L707fs	1
CPEB2	STAD	chr4	15054158	15054158	G	A	Missense_Mutation	p.R329H	1
CPEB2	BLCA	chr4	15018869	15018869	G	T	Missense_Mutation	p.D698Y	1
CPEB2	LGG	chr4	15060817	15060817	A	T	Missense_Mutation	p.I833L	1
CPEB2	SKCM	chr4	15063885	15063886	-	T	Splice_Site		1
CPEB2	CESC	chr4	15004565	15004565	C	T	Nonsense_Mutation	p.Q90*	1
CPEB2	LIHC	chr4	15060074	15060074	A	G	Missense_Mutation	p.S831G	1
CPEB2	STAD	chr4	15060834	15060834	A	G	Silent	p.L868L	1
CPEB2	GBM	chr4	15060838	15060838	G	A	Missense_Mutation	p.D870N	1
CPEB2	LUSC	chr4	15055755	15055755	A	C	Missense_Mutation	p.E792A	1
CPEB2	SKCM	chr4	15063816	15063816	C	T	Nonsense_Mutation	p.Q907X	1
CPEB2	STAD	chr4	15055827	15055827	A	G	Missense_Mutation	p.Y371C	1
CPEB2	LGG	chr4	15055831	15055831	T	C	Silent	p.F817F	1
CPEB2	SKCM	chr4	15018896	15018897	-	T	Frame_Shift_Ins	p.*707fs	1
CPEB2	STAD	chr4	15067972	15067972	C	T	Missense_Mutation	p.R1025C	1
CPEB2	GBM	chr4	15060838	15060838	G	A	Missense_Mutation		1
CPEB2	PAAD	chr4	15060083	15060083	C	T	Nonsense_Mutation	p.Q834X	1
CPEB2	SKCM	chr4	15009173	15009173	G	A	Missense_Mutation	p.R636K	1
CPEB2	STAD	chr4	15054040	15054040	C	T	Missense_Mutation	p.R290C	1
CPEB2	LGG	chr4	15060817	15060817	A	T	Missense_Mutation	p.I863L	1
CPEB2	STAD	chr4	15055785	15055785	C	A	Missense_Mutation	p.P357H	1
CPEB2	COAD	chr4	15054166	15054166	C	T	Nonsense_Mutation	p.R747X	1
CPEB2	LIHC	chr4	15060877	15060877	C	-	Frame_Shift_Del	p.P883fs	1
CPEB2	HNSC	chr4	15063828	15063828	A	G	Missense_Mutation		1
CPEB2	SKCM	chr4	15005680	15005680	C	T	Silent	p.F461F	1
CPEB2	STAD	chr4	15054156	15054156	A	G	Silent	p.E328E	1
CPEB2	LGG	chr4	15060817	15060817	A	T	Missense_Mutation		1
CPEB2	PAAD	chr4	15060083	15060083	C	T	Nonsense_Mutation	p.Q834*	1
CPEB2	STAD	chr4	15009022	15009022	C	T	Missense_Mutation	p.R149C	1
CPEB2	COAD	chr4	15060810	15060810	G	T	Splice_Site	.	1
CPEB2	LIHC	chr4	15060882	15060882	A	-	Frame_Shift_Del	p.R884fs	1
CPEB2	HNSC	chr4	15063786	15063786	A	G	Missense_Mutation		1
CPEB2	SKCM	chr4	15060078	15060078	C	T	Missense_Mutation	p.S832L	1
CPEB2	STAD	chr4	15067972	15067972	C	T	Missense_Mutation		1
CPEB2	LGG	chr4	15055831	15055831	T	C	Missense_Mutation		1
CPEB2	STAD	chr4	15009113	15009113	A	G	Missense_Mutation	p.K616R	1
CPEB2	PAAD	chr4	15060083	15060083	C	T	Nonsense_Mutation	p.Q389*	1
CPEB2	STAD	chr4	15060834	15060834	A	G	Silent	p.L423L	1
CPEB2	COAD	chr4	15063747	15063747	T	C	Missense_Mutation	p.Y884H	1
CPEB2	LIHC	chr4	15009126	15009126	A	-	Frame_Shift_Del	p.S620fs	1
CPEB2	ACC	chr4	15067858	15067858	T	-	Frame_Shift_Del	p.P986fs	1
CPEB2	HNSC	chr4	15063859	15063859	T	A	Missense_Mutation		1
CPEB2	SKCM	chr4	15067856	15067856	C	T	Missense_Mutation	p.P986L	1
CPEB2	THYM	chr4	15034808	15034808	G	T	Nonsense_Mutation	p.G717X	1
CPEB2	LIHC	chr4	15060074	15060074	A	G	Missense_Mutation		1
CPEB2	STAD	chr4	15018811	15018811	G	A	Splice_Site	.	1
CPEB2	PAAD	chr4	15060083	15060083	C	T	Nonsense_Mutation		1
CPEB2	STAD	chr4	15018811	15018811	G	A	Splice_Site	p.D242_splice	1
CPEB2	COAD	chr4	15067830	15067830	C	T	Silent	p.G947G	1
CPEB2	LIHC	chr4	15060890	15060890	T	-	Frame_Shift_Del	p.I887fs	1
CPEB2	HNSC	chr4	15054114	15054114	A	G	Silent		1
CPEB2	SKCM	chr4	15067977	15067977	A	T	Silent	p.P1026P	1
CPEB2	THYM	chr4	15005347	15005348	-	GGC	In_Frame_Ins	p.350_351PR>PAR	1
CPEB2	STAD	chr4	15063798	15063798	C	T	Nonsense_Mutation	p.R931X	1
CPEB2	LUAD	chr4	15067959	15067959	G	C	Missense_Mutation	p.K1020N	1
CPEB2	READ	chr4	15067925	15067925	G	A	Missense_Mutation	p.R979H	1
CPEB2	STAD	chr4	15063798	15063798	C	T	Nonsense_Mutation	p.R486*	1

Copy number variation (CNV) of CPEB2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across CPEB2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
81620	N/A	AX340611	ANXA4	chr2	69998097	-	CPEB2	chr4	15070560	+
81620	LUAD	TCGA-73-4659-01A	BPIFA1	chr20	31827716	+	CPEB2	chr4	15005439	+
27584	STAD	TCGA-HU-8244-01A	CPEB2	chr4	15009210	+	ATP8A1	chr4	42509171	-
89085	PRAD	TCGA-XK-AAJA-01A	CPEB2	chr4	15009210	+	LDB2	chr4	16513727	-
81631	BRCA	TCGA-B6-A0I6-01A	SHB	chr9	38067926	-	CPEB2	chr4	15060045	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	CPEB2	0.000151572278703622	0.0041
ACC	CPEB2	0.00537931826916044	0.14
TGCT	CPEB2	0.00777532462134799	0.19
THYM	CPEB2	0.0202967776284693	0.49
MESO	CPEB2	0.0230013402712388	0.53
GBM	CPEB2	0.0311328600789257	0.68
HNSC	CPEB2	3.2359037981027e-08	9.1e-07

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	CPEB2	0.0265638198411892	0.8
LGG	CPEB2	0.00123149458009987	0.041
BRCA	CPEB2	0.00204495430515051	0.065
THYM	CPEB2	0.00968574125709898	0.3

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source