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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL10L (NCBI Gene ID:140801)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL10L
	Gene ID: 140801
	Gene Symbol	RPL10L
	Gene ID	140801
	Gene Name	ribosomal protein L10 like
	Synonyms	RPL10_5_1358
	Cytomap	14q21.2
	Type of Gene	protein-coding
	Description	60S ribosomal protein L10-likelarge ribosomal subunit protein uL16-like
	Modification date	20200313
	UniProtAcc	Q96L21

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL10L	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL10L[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL10L	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUSC	RPL10L	-1.36690500854163	0.0210979717247784
COAD	RPL10L	-1.78552000802138	2.08616256713867e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
SKCM	RPL10L	2	3	0.0221548795523194	0.524225641025641	0.80590626349892	-0.3462206764906	0.0258819485301183

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LGG	RPL10L	0.068819385	0.017999698
SKCM	RPL10L	0.307013055	0.030121473
MESO	RPL10L	0.06906551	0.033066499
BRCA	RPL10L	-0.017180792	0.040873783

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL10L (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	IUPHAR	RPL10L	SSTR4	0.856591663	7.87E-24
ACC	IUPHAR	RPL10L	BIRC8	0.916995838	1.82E-32
DLBC	Cell metabolism gene	RPL10L	FSHB	0.800135377	8.89E-12
DLBC	Cell metabolism gene	RPL10L	PDHA2	0.800509306	8.55E-12
DLBC	Cell metabolism gene	RPL10L	UGT1A5	0.81579556	1.63E-12
DLBC	Cell metabolism gene	RPL10L	UGT1A3	0.81579556	1.63E-12
DLBC	Cell metabolism gene	RPL10L	GPX5	0.81579556	1.63E-12
DLBC	CGC	RPL10L	PAX7	0.903189862	1.64E-18
DLBC	Epifactor	RPL10L	USP17L2	0.80175866	7.51E-12
DLBC	Epifactor	RPL10L	HIST1H2BA	0.81579556	1.63E-12
DLBC	Epifactor	RPL10L	CDY1	0.81579556	1.63E-12
DLBC	Epifactor	RPL10L	HIST1H4G	0.81579556	1.63E-12
DLBC	Epifactor	RPL10L	H1FOO	0.81579556	1.63E-12
DLBC	IUPHAR	RPL10L	TRPC7	0.81579556	1.63E-12
DLBC	IUPHAR	RPL10L	SSTR5	0.81579556	1.63E-12
DLBC	IUPHAR	RPL10L	GPRC6A	0.81579556	1.63E-12
DLBC	IUPHAR	RPL10L	MOS	0.81579556	1.63E-12
DLBC	IUPHAR	RPL10L	SLC6A18	0.81579556	1.63E-12
DLBC	IUPHAR	RPL10L	TAAR2	0.81579556	1.63E-12
DLBC	IUPHAR	RPL10L	PRLHR	0.843381873	5.36E-14
DLBC	IUPHAR	RPL10L	SLC17A6	0.868684357	1.24E-15
DLBC	Kinase	RPL10L	MOS	0.81579556	1.63E-12
DLBC	TF	RPL10L	NKX2-6	0.81579556	1.63E-12
DLBC	TF	RPL10L	FEZF2	0.81579556	1.63E-12
DLBC	TF	RPL10L	NEUROD6	0.81579556	1.63E-12
DLBC	TF	RPL10L	TGIF2LX	0.81579556	1.63E-12
DLBC	TF	RPL10L	NKX1-2	0.81579556	1.63E-12
DLBC	TF	RPL10L	HOXB1	0.81579556	1.63E-12
DLBC	TF	RPL10L	EVX2	0.81579556	1.63E-12
DLBC	TF	RPL10L	NOTO	0.81579556	1.63E-12
DLBC	TF	RPL10L	PAX7	0.903189862	1.64E-18
KICH	Cell metabolism gene	RPL10L	MUC17	0.814640745	9.03E-23
KICH	Cell metabolism gene	RPL10L	GCG	0.889964196	4.23E-32
KICH	Cell metabolism gene	RPL10L	GPX6	0.900404408	6.32E-34
KICH	Cell metabolism gene	RPL10L	TUBA3C	0.969420016	4.36E-56
KICH	CGC	RPL10L	SSX2	0.939473025	3.56E-43
KICH	CGC	RPL10L	SSX4	0.96285366	2.17E-52
KICH	CGC	RPL10L	SSX1	0.963780412	7.20E-53
KICH	Epifactor	RPL10L	H1FNT	0.805966757	5.64E-22
KICH	Epifactor	RPL10L	H2BFWT	0.806650038	4.90E-22
KICH	Epifactor	RPL10L	HIST1H2AB	0.876496571	5.32E-30
KICH	Epifactor	RPL10L	HIST1H3I	0.889762014	4.56E-32
KICH	Epifactor	RPL10L	HIST1H4L	0.93099408	1.01E-40
KICH	IUPHAR	RPL10L	PANX3	0.853310723	6.63E-27
KICH	IUPHAR	RPL10L	MMP27	0.86176753	5.73E-28
KICH	IUPHAR	RPL10L	SLCO6A1	0.947221595	9.49E-46
KICH	TF	RPL10L	FOXR2	0.825009945	8.87E-24
KICH	TF	RPL10L	BARX1	0.825707209	7.54E-24
KICH	TF	RPL10L	TBX5	0.826422785	6.39E-24
KICH	TF	RPL10L	DMRTB1	0.835657541	6.94E-25
KICH	TF	RPL10L	PROP1	0.843461348	9.54E-26
KICH	TF	RPL10L	MYT1L	0.863793195	3.11E-28
KICH	TF	RPL10L	DMBX1	0.891536451	2.31E-32
KICH	TF	RPL10L	SPZ1	0.902066026	3.10E-34
KICH	TF	RPL10L	LIN28B	0.913845208	1.35E-36
KICH	TF	RPL10L	FEZF2	0.929265551	2.92E-40
KICH	TSG	RPL10L	PAEP	0.803591494	9.17E-22
KICH	TSG	RPL10L	TBX5	0.826422785	6.39E-24
KICH	TSG	RPL10L	GKN2	0.850785149	1.34E-26

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL10L	RPL18A	-1.51651392808885	0.00016188295558095
LUSC	RPL10L	RPL18	-2.71738134960354	0.000234071565908595
KIRP	RPL10L	RPS7	-3.08161607224061	0.000256400555372238
LUAD	RPL10L	RPL38	-1.66722943744988	0.000257795914027732
BLCA	RPL10L	RPL5	-3.50581551367555	0.00026702880859375
STAD	RPL10L	RPL5	2.24361928856279	0.000433447770774365
LUSC	RPL10L	RPL38	-2.00110253296947	0.00049723236196648
LIHC	RPL10L	RPL8	-4.84588284974558	0.00110314154326131
COAD	RPL10L	RPL18	2.06383580378934	0.00144392251968384
PRAD	RPL10L	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL10L	RPL19	1.36901182894089	0.00250792503356934
PRAD	RPL10L	RPS7	2.19690532093525	0.00482349779780149
ESCA	RPL10L	RPL15	1.76629417535644	0.0048828125
KICH	RPL10L	RPS7	2.35513673345303	0.00672554969787598
LUAD	RPL10L	RPL19	-1.31398026615725	0.00993159558412698
KICH	RPL10L	RPL18	-1.4760977092445	0.0173123478889465
KICH	RPL10L	RPL5	1.79380241489629	0.0219083428382874
PRAD	RPL10L	RPL38	-1.37307294389303	0.0319785302138518
LUSC	RPL10L	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL10L	RPL19	-2.73485271276676	1.33980982873695e-10
THCA	RPL10L	RPS2	-2.9749691422722	1.8399565126656e-05
KIRC	RPL10L	RPS2	-3.31623058345719	2.17100738110179e-12
KIRC	RPL10L	RPL18	-1.49209569505049	2.49674919862186e-10
KIRC	RPL10L	RPL38	-2.47198269993031	2.66680331214666e-11
KIRC	RPL10L	RPL35	-1.06475238059392	2.72286325678163e-08
KIRP	RPL10L	RPL38	-2.05925877790715	4.97791916131974e-07
KIRP	RPL10L	RPS2	-2.72788021566791	5.12227416038514e-08
COAD	RPL10L	RPS7	1.80899366786773	5.1647424697876e-05
KIRC	RPL10L	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL10L	RPL8	-1.53003692350119	6.0301274061203e-05
LUAD	RPL10L	RPS2	-2.88992098496468	6.51132046672323e-08
KIRP	RPL10L	RPL18	-1.45428676432035	8.19191336631775e-05
KICH	RPL10L	RPS2	-4.73426315307469	8.34465026855468e-07
KIRP	RPL10L	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL10L	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL10L

PCK1, CDK2, CUL1, COPS5, CAND1, RPS28, RPL38, RPL10A, RPL11, RPL15, RPL17, RPL18, RPL23A, RPL24, RPL6, RPL7, RPL9, RPLP0P6, RPS16, RPS19, RPS26, RPS2, RPS3A, RPS3, RPS4X, RPS5, RPS8, RPL18A, RPL7A, RPL23, RPS15A, RPS6, RPL21, RPL5, RPS11, RPS23, RPS13, RPL14, RPL19, RPL4, RPL12, RPS24, EEF1A1, MOV10, RPL31, RPS10, RPS12, RPS21, SLC25A4, RPL37A, RPL27, SLC25A6, RPL22, TUBB7P, RPLP0, RPL30, EEF2, RPS27A, NPM1, RPL27A, HNRNPU, RPSA, RPL8, RPL3, CHCHD4, S100A10, ATP6V0A2, RPS14, RPL35, RPS25, RPS7, RPA3, RPA2, RPA1, CEP76, TP53, TUBG1, RPL36, RPS15, FBXW7, MCM2, ZNF746, TRIP4, RIOK1, HEXIM1, MEPCE, LARP7, RECQL4, PLEKHA4, GRB7, MAP3K14, PTPN6, CIT, ANLN, AURKB, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, Stard13, ARHGEF17, RBM39, BKRF1, CUL4A, MAGEB2, RPL10, SPRTN,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL10L	chr14	47120439	G	C	single_nucleotide_variant	Uncertain_significance	Intellectual_developmental_disorder_with_dysmorphic_facies_and_ptosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL10L	chr14	47120683	T	G	single_nucleotide_variant	Likely_pathogenic	Spermatogenesis_maturation_arrest	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL10L	chr14	47120846	G	A	single_nucleotide_variant	Uncertain_significance	Malignant_tumor_of_prostate	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL10L	HNSC	chr14	47120418	47120418	C	T	Silent	p.T174T	10
RPL10L	SKCM	chr14	47120402	47120402	C	T	Missense_Mutation	p.E180K	6
RPL10L	SKCM	chr14	47120879	47120879	G	A	Missense_Mutation	p.R21C	5
RPL10L	HNSC	chr14	47120482	47120482	C	T	Missense_Mutation	p.R153H	5
RPL10L	ACC	chr14	47120739	47120739	G	A	Silent	p.A67A	5
RPL10L	PAAD	chr14	47120892	47120892	C	T	Silent	p.P16P	4
RPL10L	LUAD	chr14	47120456	47120456	G	T	Missense_Mutation	p.R162S	3
RPL10L	ESCA	chr14	47120380	47120380	T	C	Missense_Mutation	p.K187R	3
RPL10L	SKCM	chr14	47120366	47120366	G	A	Missense_Mutation	p.P192S	3
RPL10L	ESCA	chr14	47120593	47120593	C	G	Missense_Mutation	p.R116P	3
RPL10L	PAAD	chr14	47120810	47120810	C	A	Missense_Mutation	p.D44Y	3
RPL10L	ESCA	chr14	47120658	47120658	G	C	Missense_Mutation	p.F94L	3
RPL10L	ESCA	chr14	47120705	47120705	T	G	Missense_Mutation	p.S79R	3
RPL10L	HNSC	chr14	47120482	47120482	C	T	Missense_Mutation		3
RPL10L	LUSC	chr14	47120763	47120763	C	A	Missense_Mutation	p.Q59H	3
RPL10L	ESCA	chr14	47120896	47120896	T	C	Missense_Mutation	p.K15R	3
RPL10L	UCEC	chr14	47120570	47120570	C	T	Missense_Mutation	p.G124S	3
RPL10L	LUSC	chr14	47120507	47120507	C	T	Missense_Mutation	p.E145K	3
RPL10L	SARC	chr14	47120671	47120671	C	T	Missense_Mutation	p.R90Q	3
RPL10L	LUAD	chr14	47120853	47120853	G	T	Silent	p.A29A	3
RPL10L	PAAD	chr14	47120892	47120892	C	T	Silent		3
RPL10L	STAD	chr14	47120347	47120347	T	G	Missense_Mutation		2
RPL10L	PAAD	chr14	47120810	47120810	C	A	Missense_Mutation		2
RPL10L	UCEC	chr14	47120846	47120846	G	A	Missense_Mutation	p.R32C	2
RPL10L	GBM	chr14	47120929	47120929	C	T	Missense_Mutation	p.R4H	2
RPL10L	STAD	chr14	47120347	47120347	T	G	Missense_Mutation	p.K198T	2
RPL10L	HNSC	chr14	47120455	47120455	C	A	Missense_Mutation	p.R162L	2
RPL10L	UCEC	chr14	47120881	47120881	G	T	Missense_Mutation	p.S20Y	2
RPL10L	STAD	chr14	47120878	47120878	C	T	Missense_Mutation	p.R21H	2
RPL10L	STAD	chr14	47120431	47120431	T	G	Missense_Mutation	p.K170T	2
RPL10L	HNSC	chr14	47120636	47120636	T	C	Missense_Mutation	p.M102V	2
RPL10L	BLCA	chr14	47120421	47120421	G	A	Silent	p.F173F	2
RPL10L	LUAD	chr14	47120508	47120508	G	T	Missense_Mutation	p.N144K	2
RPL10L	STAD	chr14	47120380	47120380	T	G	Missense_Mutation	p.K187T	2
RPL10L	BLCA	chr14	47120396	47120396	C	G	Missense_Mutation	p.E182Q	2
RPL10L	STAD	chr14	47120719	47120719	T	A	Missense_Mutation	p.K74I	2
RPL10L	HNSC	chr14	47120888	47120888	G	A	Missense_Mutation	p.P18S	2
RPL10L	UCEC	chr14	47120311	47120311	C	T	Missense_Mutation	p.R210Q	2
RPL10L	ESCA	chr14	47120896	47120896	T	C	Missense_Mutation		2
RPL10L	STAD	chr14	47120831	47120831	C	T	Missense_Mutation	p.G37S	2
RPL10L	LGG	chr14	47120456	47120456	G	A	Missense_Mutation	p.R162C	2
RPL10L	SKCM	chr14	47120740	47120740	G	A	Missense_Mutation	p.A67V	2
RPL10L	UCEC	chr14	47120325	47120325	G	T	Silent	p.P205	2
RPL10L	ESCA	chr14	47120380	47120380	T	C	Missense_Mutation		2
RPL10L	STAD	chr14	47120800	47120800	G	A	Missense_Mutation	p.P47L	2
RPL10L	BRCA	chr14	47120792	47120792	C	T	Missense_Mutation	p.G50S	2
RPL10L	SKCM	chr14	47120657	47120657	G	A	Missense_Mutation	p.H95Y	2
RPL10L	UCEC	chr14	47120502	47120502	C	A	Missense_Mutation	p.E146D	2
RPL10L	ESCA	chr14	47120705	47120705	T	G	Missense_Mutation		2
RPL10L	BRCA	chr14	47120828	47120828	T	C	Missense_Mutation	p.R38G	2
RPL10L	STAD	chr14	47120567	47120567	T	C	Missense_Mutation	p.T125A	2
RPL10L	SKCM	chr14	47120662	47120662	G	A	Missense_Mutation	p.P93L	2
RPL10L	UCEC	chr14	47120530	47120530	G	A	Missense_Mutation	p.S137F	2
RPL10L	ESCA	chr14	47120593	47120593	C	G	Missense_Mutation		2
RPL10L	LUAD	chr14	47120870	47120870	G	-	Frame_Shift_Del	p.R24fs	2
RPL10L	STAD	chr14	47120402	47120402	C	T	Missense_Mutation		2
RPL10L	STAD	chr14	47120473	47120473	T	C	Missense_Mutation	p.K156R	2
RPL10L	UCEC	chr14	47120566	47120566	G	A	Missense_Mutation	p.T125I	2
RPL10L	ESCA	chr14	47120658	47120658	G	C	Missense_Mutation		2
RPL10L	LUSC	chr14	47120363	47120363	C	T	Missense_Mutation	p.D193N	1
RPL10L	BLCA	chr14	47120421	47120421	G	A	Silent		1
RPL10L	HNSC	chr14	47120850	47120850	C	G	Missense_Mutation	p.K30N	1
RPL10L	DLBC	chr14	47120688	47120688	G	C	Silent	p.G84G	1
RPL10L	LIHC	chr14	47120791	47120791	C	T	Missense_Mutation		1
RPL10L	STAD	chr14	47120511	47120511	C	A	Missense_Mutation	p.Q143H	1
RPL10L	SKCM	chr14	47121028	47121028	C	T	Splice_Site	.	1
RPL10L	LUSC	chr14	47120628	47120628	G	T	Silent	p.S104S	1
RPL10L	BLCA	chr14	47120555	47120555	C	-	Frame_Shift_Del		1
RPL10L	LIHC	chr14	47120791	47120791	C	T	Missense_Mutation	p.G50D	1
RPL10L	THYM	chr14	47120575	47120575	G	T	Missense_Mutation	p.P122H	1
RPL10L	GBM	chr14	47120841	47120841	G	-	Frame_Shift_Del	p.I33fs	1
RPL10L	LUAD	chr14	47120371	47120371	A	G	Missense_Mutation	p.L190P	1
RPL10L	LUSC	chr14	47120629	47120629	G	T	Missense_Mutation	p.S104Y	1
RPL10L	BLCA	chr14	47120396	47120396	C	G	Missense_Mutation		1
RPL10L	LUAD	chr14	47120353	47120353	C	G	Missense_Mutation	p.G196A	1
RPL10L	THYM	chr14	47120329	47120329	C	T	Missense_Mutation	p.G204D	1
RPL10L	GBM	chr14	47120933	47120933	G	A	Missense_Mutation		1
RPL10L	LUAD	chr14	47120296	47120296	C	A	Nonstop_Mutation	p.*215L	1
RPL10L	LUSC	chr14	47120699	47120699	C	A	Missense_Mutation	p.G81C	1
RPL10L	BLCA	chr14	47120529	47120529	G	C	Silent	p.S137S	1
RPL10L	LUAD	chr14	47120772	47120772	T	G	Missense_Mutation	p.E56D	1
RPL10L	PRAD	chr14	47120583	47120583	A	C	Missense_Mutation	p.F119L	1
RPL10L	THYM	chr14	47120304	47120304	C	T	Silent	p.L212L	1
RPL10L	SKCM	chr14	47120333	47120333	G	A	Missense_Mutation	p.H203Y	1
RPL10L	HNSC	chr14	47120418	47120418	C	T	Silent		1
RPL10L	LUAD	chr14	47120939	47120939	T	C	Translation_Start_Site	p.M1V	1
RPL10L	LUSC	chr14	47120931	47120931	G	T	Silent	p.R3R	1
RPL10L	STAD	chr14	47120898	47120898	G	C	Missense_Mutation	p.N14K	1
RPL10L	LUAD	chr14	47120507	47120507	C	A	Nonsense_Mutation	p.E145*	1
RPL10L	SARC	chr14	47120671	47120671	C	T	Missense_Mutation		1
RPL10L	THYM	chr14	47120525	47120525	G	T	Missense_Mutation	p.R139S	1
RPL10L	HNSC	chr14	47120595	47120595	C	T	Missense_Mutation	p.M115I	1
RPL10L	LUAD	chr14	47120603	47120603	T	C	Missense_Mutation	p.T113A	1
RPL10L	SARC	chr14	47120454	47120454	G	T	Silent		1
RPL10L	SKCM	chr14	47120811	47120811	C	T	Silent	p.V43V	1
RPL10L	HNSC	chr14	47120968	47120968	G	A	Missense_Mutation		1
RPL10L	LUAD	chr14	47120662	47120662	G	C	Missense_Mutation	p.P93R	1
RPL10L	BLCA	chr14	47120594	47120594	G	A	Nonsense_Mutation	p.R116*	1
RPL10L	LUAD	chr14	47120689	47120689	C	A	Missense_Mutation	p.G84V	1
RPL10L	SKCM	chr14	47120221	47120221	T	C	Splice_Site		1
RPL10L	HNSC	chr14	47120850	47120850	C	G	Missense_Mutation		1
RPL10L	LUSC	chr14	47120930	47120930	G	T	Missense_Mutation	p.R4S	1
RPL10L	BLCA	chr14	47120555	47120555	C	-	Frame_Shift_Del	p.V129fs	1
RPL10L	SKCM	chr14	47120582	47120582	C	T	Missense_Mutation	p.G120R	1
RPL10L	HNSC	chr14	47120888	47120888	G	A	Missense_Mutation		1
RPL10L	LGG	chr14	47120403	47120403	G	A	Silent	p.D179D	1
RPL10L	LUSC	chr14	47120615	47120615	C	G	Missense_Mutation	p.D109H	1
RPL10L	LUAD	chr14	47120666	47120666	G	T	Missense_Mutation	p.H92N	1
RPL10L	LUAD	chr14	47120343	47120343	G	C	Nonsense_Mutation	p.Y199*	1
RPL10L	SKCM	chr14	47120921	47120921	G	A	Missense_Mutation	p.R7C	1
RPL10L	HNSC	chr14	47120595	47120595	C	T	Missense_Mutation		1
RPL10L	LGG	chr14	47120403	47120403	G	A	Silent		1
RPL10L	OV	chr14	47120738	47120738	C	T	Missense_Mutation	p.A68T	1
RPL10L	LUAD	chr14	47120736	47120736	G	C	Silent	p.A68A	1
RPL10L	BLCA	chr14	47120529	47120529	G	C	Silent		1
RPL10L	HNSC	chr14	47120455	47120455	C	A	Missense_Mutation		1
RPL10L	COAD	chr14	47120524	47120524	C	T	Missense_Mutation	p.R139H	1
RPL10L	LGG	chr14	47120456	47120456	G	A	Missense_Mutation		1
RPL10L	SKCM	chr14	47121027	47121027	C	T	Splice_Site	.	1
RPL10L	LUAD	chr14	47120935	47120935	C	A	Missense_Mutation	p.G2V	1

Copy number variation (CNV) of RPL10L
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL10L
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	RPL10L	0.00225729722883581	0.063
BRCA	RPL10L	0.0113151068801643	0.31

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	RPL10L	0.00829506442399226	0.27
SARC	RPL10L	0.0451012848749243	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source