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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: DAPK1 (NCBI Gene ID:1612)


Gene Summary

check button Gene Summary
Gene InformationGene Name: DAPK1
Gene ID: 1612
Gene Symbol

DAPK1

Gene ID

1612

Gene Namedeath associated protein kinase 1
SynonymsDAPK|ROCO3
Cytomap

9q21.33

Type of Geneprotein-coding
Descriptiondeath-associated protein kinase 1DAP kinase 1
Modification date20200313
UniProtAcc

P53355


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0017148Negative regulation of translation
GO:0006417Regulation of translation
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDAPK1

GO:0006468

protein phosphorylation

10629061

HgeneDAPK1

GO:0017148

negative regulation of translation

18995835

HgeneDAPK1

GO:0035556

intracellular signal transduction

10629061

HgeneDAPK1

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

16132846

HgeneDAPK1

GO:0046777

protein autophosphorylation

10629061|12730201

HgeneDAPK1

GO:0071346

cellular response to interferon-gamma

18995835



check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
DAPK1(733 - 1119.25]


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Translation Studies in PubMed

check button We searched PubMed using 'DAPK1[title] AND translation [title] AND human.'
GeneTitlePMID
DAPK1..


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST000003580779021986890220090In-frame
ENST000004089549021986890220090In-frame
ENST000004722849021986890220090In-frame
ENST000003580779025285790252996Frame-shift
ENST000004089549025285790252996Frame-shift
ENST000004722849025285790252996Frame-shift
ENST000003580779025456490254613Frame-shift
ENST000004089549025456490254613Frame-shift
ENST000004722849025456490254613Frame-shift
ENST000003580779025829090258383In-frame
ENST000004089549025829090258383In-frame
ENST000004722849025829090258383In-frame
ENST000003580779026137590261474In-frame
ENST000004089549026137590261474In-frame
ENST000004722849026137590261474In-frame
ENST000003580779027294390273042In-frame
ENST000004089549027294390273042In-frame
ENST000004722849027294390273042In-frame
ENST000003580779030146590301654In-frame
ENST000004089549030146590301654In-frame
ENST000004722849030146590301654In-frame
ENST000003580779031192190312119In-frame
ENST000004089549031192190312119In-frame
ENST000004722849031192190312119In-frame
ENST000003580779031357090313709Frame-shift
ENST000004089549031357090313709Frame-shift
ENST000004722849031357090313709Frame-shift

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)
ENST000003580779021986890220090576024646714302194
ENST000004722849021986890220090577626348414302194
ENST000004089549021986890220090590939861914302194
ENST0000035807790258290902583835760110211941430306337
ENST0000047228490258290902583835776111912111430306337
ENST0000040895490258290902583835909125413461430306337
ENST0000035807790261375902614745760131514131430377410
ENST0000047228490261375902614745776133214301430377410
ENST0000040895490261375902614745909146715651430377410
ENST0000035807790272943902730425760200821061430608641
ENST0000047228490272943902730425776202521231430608641
ENST0000040895490272943902730425909216022581430608641
ENST0000035807790301465903016545760240825961430741804
ENST0000047228490301465903016545776242526131430741804
ENST0000040895490301465903016545909256027481430741804
ENST0000035807790311921903121195760259727941430804870
ENST0000047228490311921903121195776261428111430804870
ENST0000040895490311921903121195909274929461430804870

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.
P5335530633711430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335580487011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355219411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335537741011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335560864111430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335574180411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335530633711430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335580487011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355219411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335537741011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335560864111430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335574180411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335530633711430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335580487011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355219411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335537741011430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335560864111430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P5335574180411430ChainID=PRO_0000085910;Note=Death-associated protein kinase 1
P53355219413275DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P53355219413275DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P53355219413275DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P53355377410378407RepeatNote=ANK 1
P53355377410378407RepeatNote=ANK 1
P53355377410378407RepeatNote=ANK 1
P53355608641609638RepeatNote=ANK 8
P53355608641609638RepeatNote=ANK 8
P53355608641609638RepeatNote=ANK 8
P53355804870681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P53355741804681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P53355804870681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P53355741804681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P53355804870681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P53355741804681955DomainNote=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
P5335521941927Nucleotide bindingNote=ATP
P5335521941927Nucleotide bindingNote=ATP
P5335521941927Nucleotide bindingNote=ATP
P5335521949496Nucleotide bindingNote=ATP
P5335521949496Nucleotide bindingNote=ATP
P5335521949496Nucleotide bindingNote=ATP
P53355306337267334RegionNote=Calmodulin-binding
P53355306337267334RegionNote=Calmodulin-binding
P53355306337267334RegionNote=Calmodulin-binding
P5335521944242Binding siteNote=ATP
P5335521944242Binding siteNote=ATP
P5335521944242Binding siteNote=ATP
P53355306337308308Modified residueNote=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
P53355306337308308Modified residueNote=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
P53355306337308308Modified residueNote=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
P53355306337319319Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
P53355306337319319Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
P53355306337319319Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
P53355306337333333Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
P53355306337333333Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
P53355306337333333Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
P533553063371446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335521941446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533553774101446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533553063371446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335521941446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533553774101446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533553063371446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P5335521941446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533553774101446Alternative sequenceID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53355741804742783Alternative sequenceID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53355741804742783Alternative sequenceID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53355741804742783Alternative sequenceID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533558048707841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533557418047841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533558048707841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533557418047841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533558048707841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P533557418047841430Alternative sequenceID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53355804870805870Alternative sequenceID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
P53355804870805870Alternative sequenceID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
P53355804870805870Alternative sequenceID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
P53355608641622622Natural variantID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
P53355608641622622Natural variantID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
P53355608641622622Natural variantID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
P5335521944242MutagenesisNote=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
P5335521944242MutagenesisNote=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
P5335521944242MutagenesisNote=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
P53355306337308308MutagenesisNote=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337308308MutagenesisNote=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337313313MutagenesisNote=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337313313MutagenesisNote=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P53355306337313313MutagenesisNote=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
P5335521941321Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521941321Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521941321Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521942332Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521942332Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521942332Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943335TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943335TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943335TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943846Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943846Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521943846Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521944851Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
P5335521944851Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
P5335521944851Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
P5335521945356Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521945356Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521945356Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521945870HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521945870HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521945870HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521947984Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521947984Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521947984Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521948694Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521948694Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P5335521948694Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
P53355306337304318HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
P53355306337304318HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
P53355306337304318HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
COADDAPK12.686464644854950.00613072514533998
LIHCDAPK1-1.540537523232581.9834194260622e-05
LUADDAPK1-1.414430139292512.06541148982154e-09
THCADAPK12.391232678483363.38795198769543e-06


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a
COADDAPK1320.01056349552674650.6413058159096370.5492028198769180.1293817429279030.0260926587998054
LUADDAPK1320.04858683475099330.6111003472222220.5449947949735450.161298352516975-0.0537882546258627

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a
HNSCDAPK1320.02744146577651960.6802693705975910.529738095238095-0.1047784689947110.0307866920201429
SARCDAPK1320.01351565128688620.8056451980792320.493555299539171-0.1586206447607170.167893356323587

check buttonTranslation factor expression regulation through copy number variation of Translation factor
all structure
Cancer typeGeneCoefficientPvalue

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with DAPK1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
all structure
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue
DLBCCell metabolism geneDAPK1GALNT110.8052786935.18E-12
DLBCCell metabolism geneDAPK1PLA2G4A0.8582198126.42E-15
DLBCCell metabolism geneDAPK1DPYD0.8706339198.98E-16
DLBCCell metabolism geneDAPK1LPCAT20.882093651.21E-16
DLBCCGCDAPK1CYSLTR20.8012451397.93E-12
DLBCCGCDAPK1NCOA40.8390545449.55E-14
DLBCCGCDAPK1NFE2L20.8526045991.47E-14
DLBCEpifactorDAPK1UBE2D10.8147040761.85E-12
DLBCIUPHARDAPK1CYSLTR20.8012451397.93E-12
DLBCIUPHARDAPK1SLC36A10.8038779166.01E-12
DLBCIUPHARDAPK1IRAK30.8050891615.29E-12
DLBCIUPHARDAPK1NPC10.8101009313.08E-12
DLBCIUPHARDAPK1SGK30.8131146922.21E-12
DLBCIUPHARDAPK1DAGLA0.8135813652.09E-12
DLBCIUPHARDAPK1CCR50.8136844892.07E-12
DLBCIUPHARDAPK1PTPRE0.8158355761.62E-12
DLBCIUPHARDAPK1P2RX70.8177984931.30E-12
DLBCIUPHARDAPK1TLR50.819535481.06E-12
DLBCIUPHARDAPK1CLEC7A0.8198595841.02E-12
DLBCIUPHARDAPK1GPR1410.8238853116.37E-13
DLBCIUPHARDAPK1SLC8A10.8424294766.09E-14
DLBCIUPHARDAPK1NFE2L20.8526045991.47E-14
DLBCIUPHARDAPK1PLA2G4A0.8582198126.42E-15
DLBCIUPHARDAPK1DPYD0.8706339198.98E-16
DLBCKinaseDAPK1IRAK30.8050891615.29E-12
DLBCKinaseDAPK1SGK30.8131146922.21E-12
DLBCTFDAPK1KLF30.8071800124.23E-12
DLBCTFDAPK1NFE2L20.8526045991.47E-14
DLBCTSGDAPK1IGF2R0.8108789442.83E-12
DLBCTSGDAPK1NCOA40.8390545449.55E-14
KICHCell metabolism geneDAPK1GALNT140.8001202921.84E-21
KICHCell metabolism geneDAPK1LBR0.8026986241.10E-21
KICHCell metabolism geneDAPK1MGAT4A0.8117983631.66E-22
KICHCell metabolism geneDAPK1POLR3GL0.8213087192.06E-23
KICHCell metabolism geneDAPK1PRODH0.8240920541.10E-23
KICHCell metabolism geneDAPK1KIFC30.8591913541.23E-27
KICHEpifactorDAPK1LBR0.8026986241.10E-21
KICHEpifactorDAPK1ARRB10.8685022957.23E-29
KICHIUPHARDAPK1SCTR0.8070105124.55E-22
KICHIUPHARDAPK1GJB10.8093788362.77E-22
KICHIUPHARDAPK1PRKX0.8102971762.29E-22
KICHIUPHARDAPK1CPM0.8130374691.28E-22
KICHIUPHARDAPK1PTGER20.8131905661.23E-22
KICHIUPHARDAPK1SLC22A170.8132862021.21E-22
KICHIUPHARDAPK1ADRA2C0.8155457047.41E-23
KICHIUPHARDAPK1SPNS20.8221399621.71E-23
KICHIUPHARDAPK1TRIB20.8355720827.09E-25
KICHIUPHARDAPK1TACSTD20.8363571875.84E-25
KICHIUPHARDAPK1HUNK0.8671454831.11E-28
KICHIUPHARDAPK1LRRK20.8733622311.51E-29
KICHKinaseDAPK1PRKX0.8102971762.29E-22
KICHKinaseDAPK1TRIB20.8355720827.09E-25
KICHKinaseDAPK1HUNK0.8671454831.11E-28
KICHKinaseDAPK1LRRK20.8733622311.51E-29
KICHTFDAPK1IRX30.8002274151.80E-21
KICHTFDAPK1IRX50.8017392711.33E-21
KICHTFDAPK1GLIS30.802367161.17E-21
KICHTFDAPK1DZIP10.8059995985.60E-22
KICHTFDAPK1FOXJ10.8073901164.20E-22
KICHTFDAPK1TRERF10.8083425863.45E-22
KICHTFDAPK1ZNF6080.880075541.56E-30
KICHTSGDAPK1CASC10.8021874991.22E-21
KICHTSGDAPK1STARD130.8100705422.40E-22
KICHTSGDAPK1AJAP10.8133138391.20E-22
KICHTSGDAPK1RASAL10.819125513.37E-23
KICHTSGDAPK1PRODH0.8240920541.10E-23
KICHTSGDAPK1RHOB0.8348150658.55E-25
THYMIUPHARDAPK1HIPK10.8095519081.56E-29
THYMIUPHARDAPK1SRPK20.8230194882.93E-31
THYMKinaseDAPK1HIPK10.8095519081.56E-29
THYMKinaseDAPK1SRPK20.8230194882.93E-31
UCSIUPHARDAPK1HIPK10.8095519081.56E-29
UCSIUPHARDAPK1SRPK20.8230194882.93E-31
UCSKinaseDAPK1HIPK10.8095519081.56E-29
UCSKinaseDAPK1SRPK20.8230194882.93E-31


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
check button
* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
COADDAPK1CALM2-2.738224144063980.000109195709228516
BRCADAPK1NTN1-4.334086289605810.000397558024007123
PRADDAPK1CALM2-1.360089370474260.000529873135893225
KIRPDAPK1UNC5B2.060727487879060.000772962812334299
LUSCDAPK1NTN11.159138503861620.00128286382207415
BRCADAPK1MAPK3-1.619099761392630.00193136402459222
CHOLDAPK1MAPK3-1.540681934246760.00390625
KICHDAPK1UNC5B-3.483423970584470.00417518615722656
HNSCDAPK1UNC5B1.078708861676980.0074030871951436
UCECDAPK1TP532.032950383766940.015625
HNSCDAPK1BECN1-2.309301094612520.0224968952327345
BLCADAPK1CALM2-2.152957813347870.0229873657226562
READDAPK1CALM2-4.273497512729410.03125
CHOLDAPK1UNC5B-2.948344561633820.0390625
THCADAPK1UNC5B-6.516447061987341.06592088122663e-10
KIRCDAPK1CALM1-3.737862458196021.16831478033445e-08
COADDAPK1GRIN2B1.803891746020342.08616256713867e-06
KIRCDAPK1NTN12.609000195779682.56680392646286e-11
COADDAPK1CALM1-5.51840566486742.98023223876954e-08
THCADAPK1NTN11.379685765742893.19237330032305e-09
STADDAPK1CALM1-2.625764381225454.20957803726197e-07
KIRCDAPK1TP53-1.430509811506324.58942580328929e-09
COADDAPK1MAPK3-1.171732831463525.66244125366212e-07
STADDAPK1NTN1-1.891818286874925.8719888329506e-07
KIRCDAPK1CALM21.443178965109246.02390727604811e-08
THCADAPK1TP53-1.819601436356476.18215597921662e-07
KIRCDAPK1GRIN2B-4.924220687376746.24336886728621e-06
LIHCDAPK1CALM11.81500936696436.64579404273587e-07
COADDAPK1CALM3-4.213713720195449.14931297302247e-06


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with DAPK1
TNFRSF1A, KRIT1, FADD, YWHAQ, TP53, HSP90AA1, ST13, CCNDBP1, IKBKG, KLHL20, CUL3, LNX1, CALM1, MIB1, DAPK1, LRRK2, LRRK1, MDM2, MAPK3, MAPK1, MYL12B, BECN1, PDCD6, Mib1, PPP2R2D, PPP2R5A, PPP2CA, PPP2R1A, ACTC1, TTLL3, BAG2, CAPZA2, CAPZB, CORO1C, DDX5, EEF2, IFI30, MYO1B, MYO1D, SVIL, TMOD3, TPM3, TWF1, TSC2, TSC1, UNC5B, PPP2R1B, UNC5A, UNC5C, IVNS1ABP, ERP44, NR3C1, TNIP2, DTWD1, SLAIN2, VN1R1, TAS2R60, ZAP70, FBXL14, ABLIM1, PIM2, RCHY1, TTC27, SPATS2, PWP1, CMTM4, SH2D2A, ABL1, AHDC1, FIBP, SGK2, CDC42SE1, SCEL, SCYL1, LOXL2, VGLL4, CAPRIN1, PCP4, C17orf82, PRR16, FBXW11, MCM10, RPAP3, STARD3, EPHA1, MTHFD2, RFC5, SCRN3, C11orf63, ARRDC1-AS1, PRKAG2, ATF6, SNURF, LIMA1, PHKG2, CBLB, NECAP1, CDC42EP3, RHBDD1, DUS1L, POLR2M, C11orf65, TBC1D22B, BAIAP2, LMF2, SRSF10, ZMAT4, SNRPA, LIMS1, DUX3, ORMDL2, STUB1, SARNP, FAM126B, GTF2F1, PIM1, SNX9, CCDC149, PAK6, NECAB1, PAPSS2, FAM107A, MRGBP, TRAPPC2, RAPGEF3, PPP1R14A, DENND1C, RPL41, ARRDC1, FAM198B, WWTR1, APEX2, SPRR2G, C17orf85, TUBB4B, RASGRP2, TPD52L1, ZMYM5, CNTROB, AGR2, HRAS, HIST1H2BH, HYOU1, PELI1, LAMP2, RAB11A, EIF4ENIF1, PRRC2B,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo
DAPK1chr990114025TCsingle_nucleotide_variantLikely_benignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990114034CTsingle_nucleotide_variantLikely_benignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990252852TCsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
DAPK1chr990252939AGsingle_nucleotide_variantBenignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990255222GAsingle_nucleotide_variantLikely_benignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990255708CGsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
DAPK1chr990258281TAsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
DAPK1chr990258281TTTAInsertionBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
DAPK1chr990258282ATsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
DAPK1chr990260938CTsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
DAPK1chr990261369AGsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
DAPK1chr990261453GAsingle_nucleotide_variantBenignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990262214CGsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
DAPK1chr990262282CTsingle_nucleotide_variantBenignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990266540GAsingle_nucleotide_variantLikely_benignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990283559CTsingle_nucleotide_variantBenignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990283560GTsingle_nucleotide_variantLikely_benignnot_providedSO:0001583|missense_variantSO:0001583|missense_variant
DAPK1chr990301641CTsingle_nucleotide_variantLikely_benignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990318048GTsingle_nucleotide_variantBenignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990321043GAsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
DAPK1chr990321802GTsingle_nucleotide_variantLikely_benignnot_providedSO:0001583|missense_variantSO:0001583|missense_variant
DAPK1chr990321850CTsingle_nucleotide_variantLikely_benignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990321862AGsingle_nucleotide_variantBenignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990322027CTsingle_nucleotide_variantBenignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990322029GTsingle_nucleotide_variantLikely_benignnot_providedSO:0001583|missense_variantSO:0001583|missense_variant
DAPK1chr990322150CTsingle_nucleotide_variantLikely_benignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
DAPK1chr990322200GTsingle_nucleotide_variantBenignnot_providedSO:0001583|missense_variantSO:0001583|missense_variant


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
DAPK1PAADchr99025830090258300CTMissense_Mutationp.R310C6
DAPK1STADchr99032180290321802G-Frame_Shift_Delp.M1272fs6
DAPK1COADchr99032180190321802-GGFrame_Shift_Insp.M1272fs5
DAPK1UCECchr99026371790263717GAMissense_Mutationp.V451M5
DAPK1PRADchr99026143690261436CGMissense_Mutationp.L398V4
DAPK1UCECchr99031511590315115GAMissense_Mutationp.R945Q4
DAPK1HNSCchr99029635290296352CTNonsense_Mutationp.R679*4
DAPK1BRCAchr99022007990220079GTSilentp.L914
DAPK1BRCAchr99025286790252867TASilentp.G984
DAPK1ESCAchr99032180190321802-GFrame_Shift_Insp.R1297fs4
DAPK1KIRPchr99032182190321821TGMissense_Mutationp.F1279V4
DAPK1KIRPchr99025428990254289GCMissense_Mutationp.L148F4
DAPK1BRCAchr99032216090322160TAMissense_Mutationp.L1392M3
DAPK1KICHchr99032126090321260GAMissense_Mutationp.A1092T3
DAPK1SKCMchr99025438490254384CTMissense_Mutationp.T180I3
DAPK1HNSCchr99032193090321930GAMissense_Mutationp.R1340H3
DAPK1UCECchr99011403890114038GCMissense_Mutationp.G16R3
DAPK1LUADchr99022004690220046CTSilentp.H80H3
DAPK1LIHCchr99027297090272970GASilent3
DAPK1CHOLchr99025435290254352CGMissense_Mutation3
DAPK1CESCchr99029636390296363GASilent3
DAPK1PRADchr99025288590252885CTSilentp.F104F3
DAPK1BRCAchr99021992690219926CTSilentp.A403
DAPK1ESCAchr99025287190252871GAMissense_Mutationp.E100K3
DAPK1CHOLchr99025435290254352CGMissense_Mutationp.D169E3
DAPK1ESCAchr99029651590296515CAMissense_Mutationp.P733H3
DAPK1PRADchr99021989890219898GAMissense_Mutationp.R31H3
DAPK1BRCAchr99025692190256921CGNonsense_Mutationp.S289*3
DAPK1HNSCchr99032193090321930GAMissense_Mutation3
DAPK1UVMchr99021997890219978CTMissense_Mutationp.R58C3
DAPK1BRCAchr99032191490321914CTMissense_Mutationp.R1310W3
DAPK1ACCchr99031805790318057GTSilentp.V995V2
DAPK1BLCAchr99029640790296407GAMissense_Mutationp.G697E2
DAPK1STADchr99032113790321137GAMissense_Mutationp.V1051M2
DAPK1UCECchr99026652690266526GAMissense_Mutationp.D571N2
DAPK1THYMchr99021995890219958CTMissense_Mutationp.S51F2
DAPK1UCECchr99032175790321757CAMissense_Mutationp.F1257L2
DAPK1UCECchr99021990290219902GTMissense_Mutationp.E32D2
DAPK1CESCchr99022006690220066CTMissense_Mutationp.T87M2
DAPK1ESCAchr99032198690321986TGMissense_Mutation2
DAPK1STADchr99026225090262250CTMissense_Mutation2
DAPK1BLCAchr99028355690283556GCMissense_Mutationp.E656D2
DAPK1STADchr99026492890264928GTMissense_Mutationp.K507N2
DAPK1KIRPchr99032182190321821TGMissense_Mutation2
DAPK1UCECchr99029640590296405GASilentp.S6962
DAPK1UCECchr99032197690321976CTSilentp.L13302
DAPK1ESCAchr99025287190252871GAMissense_Mutation2
DAPK1STADchr99026225090262250CTMissense_Mutationp.R421W2
DAPK1UCECchr99025287090252870CTSilentp.G992
DAPK1BLCAchr99025291390252913GAMissense_Mutationp.E114K2
DAPK1PAADchr99021996690219966CTMissense_Mutationp.R54W2
DAPK1BLCAchr99026655890266558CTSilentp.L581L2
DAPK1STADchr99031507990315079CTMissense_Mutationp.A933V2
DAPK1UCECchr99030158190301581GASilentp.P7802
DAPK1LIHCchr99031505290315052T-Frame_Shift_Delp.I924fs2
DAPK1LGGchr99030156090301560GAMissense_Mutation2
DAPK1UCECchr99032200390322003CTSilentp.L13392
DAPK1CESCchr99022006690220066CTMissense_Mutation2
DAPK1ESCAchr99032198690321986TGMissense_Mutationp.L1359V2
DAPK1ESCAchr99029651590296515CAMissense_Mutation2
DAPK1UCECchr99025294390252943CTMissense_Mutationp.L124F2
DAPK1BLCAchr99028358490283584CTNonsense_Mutationp.R666*2
DAPK1ACCchr99032115490321154GASilentp.A1081A2
DAPK1BLCAchr99026228090262280CGMissense_Mutationp.L431V2
DAPK1STADchr99031211190312111A-Frame_Shift_Delp.E868fs2
DAPK1UCECchr99031200790312007GTSilentp.T8332
DAPK1UCECchr99032213490322134TCMissense_Mutationp.L1383P2
DAPK1SARCchr99032116890321168GAMissense_Mutation2
DAPK1STADchr99030157390301573GTMissense_Mutationp.V778L2
DAPK1KIRCchr99031196390311963GTMissense_Mutationp.V819L2
DAPK1UCECchr99025297890252978CTSilentp.I1352
DAPK1STADchr99025427090254270CAMissense_Mutationp.P142H2
DAPK1HNSCchr99027295990272959CTSilentp.L614L2
DAPK1UCECchr99032215090322150CTSilentp.A13882
DAPK1ESCAchr99025458590254585GAMissense_Mutationp.E192K2
DAPK1SKCMchr99031368590313685CTMissense_Mutationp.S909L2
DAPK1STADchr99031795590317955CTSilentp.P961P2
DAPK1KIRCchr99025529790255297TCSilentp.D238D2
DAPK1UCECchr99025439390254393TGMissense_Mutationp.F183C2
DAPK1LIHCchr99031803690318036GASilent2
DAPK1CHOLchr99025534090255340AGMissense_Mutation2
DAPK1SKCMchr99031208590312085CTSilentp.F859F2
DAPK1UCECchr99031512090315120CAMissense_Mutationp.H947N2
DAPK1HNSCchr99029636390296363GCMissense_Mutationp.Q682H2
DAPK1UCECchr99032222490322224CTMissense_Mutationp.S1413L2
DAPK1SARCchr99025297990252979GAMissense_Mutation2
DAPK1ESCAchr99025460690254606GTMissense_Mutationp.D199Y2
DAPK1UCECchr99025471090254710CTMissense_Mutationp.S187L2
DAPK1CHOLchr99025534090255340AGMissense_Mutationp.R253G2
DAPK1LGGchr99030156090301560GAMissense_Mutationp.M773I2
DAPK1UCECchr99031513590315135CTNonsense_Mutationp.R952*2
DAPK1UVMchr99021997890219978CTMissense_Mutation2
DAPK1CESCchr99026484290264842GCMissense_Mutation2
DAPK1SARCchr99029640590296405GASilentp.S696S2
DAPK1ESCAchr99032206590322065CTMissense_Mutationp.A1385V2
DAPK1SKCMchr99021996790219967GAMissense_Mutationp.R54Q2
DAPK1STADchr99026494590264945CTMissense_Mutationp.T513M2
DAPK1UCECchr99025533190255331GTMissense_Mutationp.D250Y2
DAPK1STADchr99026371190263711CAMissense_Mutationp.L449I2
DAPK1UCECchr99032111990321119CAMissense_Mutationp.L1045M2
DAPK1LGGchr99032185090321850CTSilent2
DAPK1UVMchr99032155790321557GAMissense_Mutation2
DAPK1CESCchr99030151590301515GASilent2
DAPK1SARCchr99032107490321074CTNonsense_Mutationp.Q1055*2
DAPK1ESCAchr99032118190321181CTSilent2
DAPK1SKCMchr99032111890321118CTSilentp.V1069V2
DAPK1SKCMchr99021996890219968GASilentp.R54R2
DAPK1STADchr99031362490313624GAMissense_Mutationp.A889T2
DAPK1UCECchr99025534390255343ACSilentp.R2542
DAPK1LUADchr99031208890312088GTSilentp.L860L2
DAPK1STADchr99026656190266561TAMissense_Mutationp.H582Q2
DAPK1UCECchr99032119690321196GASilentp.Q10702
DAPK1SARCchr99028351290283512GAMissense_Mutation2
DAPK1CESCchr99032137590321375GAMissense_Mutation2
DAPK1SARCchr99032116890321168GAMissense_Mutationp.R1086Q2
DAPK1COADchr99032132790321327GAMissense_Mutationp.R1114H2
DAPK1STADchr99025531890255318TCSilentp.S245S2
DAPK1UCECchr99025832290258322GTMissense_Mutationp.R317I2
DAPK1PAADchr99021996690219966CTMissense_Mutation2
DAPK1PRADchr99026228990262289AGMissense_Mutationp.N434D2
DAPK1ESCAchr99032132790321327GAMissense_Mutationp.R1139H2
DAPK1STADchr99031368690313686GASilentp.S909S2
DAPK1HNSCchr99026486890264868GANonsense_Mutationp.W487*2
DAPK1UCECchr99032147590321475CTSilentp.G11632
DAPK1COADchr99025296690252966CTSilentp.H131H2
DAPK1ESCAchr99032132790321327GAMissense_Mutation2
DAPK1BLCAchr99026230990262309GTSilentp.V440V2
DAPK1SKCMchr99030155590301555GAMissense_Mutationp.G772R2
DAPK1STADchr99028352390283523GASilentp.T645T2
DAPK1UCECchr99026376790263767CTSilentp.F4672
DAPK1LIHCchr99027297090272970GASilentp.A617A2
DAPK1LUADchr99025572090255720GCMissense_Mutationp.K262N2
DAPK1STADchr99032173090321730CTSilentp.P1248P2
DAPK1UCECchr99032172790321727GASilentp.E12472
DAPK1HNSCchr99032193090321930GAMissense_Mutationp.R1315H2
DAPK1UVMchr99032155790321557GAMissense_Mutationp.G1216S2
DAPK1BLCAchr99027295990272959CTSilent2
DAPK1CESCchr99029636690296366CAMissense_Mutation2
DAPK1SARCchr99025297990252979GAMissense_Mutationp.A136T2
DAPK1COADchr99032158390321583CTSilentp.R1199R1
DAPK1SKCMchr99032204590322045CTSilentp.F1353F1
DAPK1GBMchr99026658790266587CTMissense_Mutationp.P591L1
DAPK1KIRPchr99031211490312114CGMissense_Mutationp.P869R1
DAPK1LIHCchr99031803690318036GASilentp.L1013L1
DAPK1LIHCchr99031676090316760C-Frame_Shift_Delp.P961fs1
DAPK1PAADchr99030163090301630GTMissense_Mutation1
DAPK1LUADchr99032149590321495GCMissense_Mutationp.W1195S1
DAPK1READchr99025439890254398GAMissense_Mutationp.A185T1
DAPK1BLCAchr99026228290262282CGSilent1
DAPK1ESCAchr99032180190321802-GFrame_Shift_Insp.Y1300fs1
DAPK1SKCMchr99032118090321180CTMissense_Mutationp.T1090I1
DAPK1HNSCchr99011399690113996AGMissense_Mutation1
DAPK1STADchr99021993890219938CTSilentp.I44I1
DAPK1HNSCchr99032133890321338GAMissense_Mutationp.D1143N1
DAPK1LGGchr99027303290273032CTMissense_Mutationp.A638V1
DAPK1LIHCchr99026662790266627CTSilent1
DAPK1LUSCchr99032144090321440CTSilentp.L1152L1
DAPK1SARCchr99032114990321149CTMissense_Mutation1
DAPK1BLCAchr99026145390261453GASilent1
DAPK1COADchr99026485190264851CTSilentp.L482L1
DAPK1SARCchr99028351290283512GASplice_Sitep.D642_splice1
DAPK1ACCchr99032115490321154GASilentp.A1056A1
DAPK1COADchr99032176190321761CTMissense_Mutationp.R1259W1
DAPK1GBMchr99022008290220082CTSilentp.I92I1
DAPK1LIHCchr99032217390322173C-Frame_Shift_Delp.S1422fs1
DAPK1LIHCchr99025434490254344A-Frame_Shift_Delp.K167fs1
DAPK1LGGchr99027295090272950CTNonsense_Mutationp.R611*1
DAPK1LUADchr99032149590321495GTMissense_Mutationp.W1195L1
DAPK1READchr99030154290301542GASilentp.P767P1
DAPK1BLCAchr99026230990262309GTSilent1
DAPK1BRCAchr99026652390266523GAMissense_Mutationp.V570I1
DAPK1ESCAchr99032194990321949C-Frame_Shift_Delp.L1348fs1
DAPK1SKCMchr99022001990220019CTSilentp.I71I1
DAPK1HNSCchr99032166490321664GASilent1
DAPK1STADchr99032137990321379CTSilentp.I1131I1
DAPK1THYMchr99021995890219958CTMissense_Mutation1
DAPK1SARCchr99030153990301539GTMissense_Mutationp.E766D1
DAPK1KIRCchr99025292690252933AATTTCTC-Frame_Shift_Delp.118_120del1
DAPK1LIHCchr99025428590254285TCMissense_Mutation1
DAPK1LUSCchr99026222090262220GTMissense_Mutationp.G411_splice1
DAPK1SARCchr99011393190113931GTMissense_Mutation1
DAPK1CESCchr99029636390296363GASilentp.Q6821
DAPK1COADchr99026498090264980GAMissense_Mutationp.D525N1
DAPK1LIHCchr99025437790254377T-Frame_Shift_Delp.F178fs1
DAPK1ACCchr99031805790318057GTSilentp.V1020V1
DAPK1SKCMchr99032111890321118CTSilentp.V1044V1
DAPK1GBMchr99025289790252897GTMissense_Mutation1
DAPK1KIRPchr99025428990254289GCMissense_Mutation1
DAPK1HNSCchr99032166490321664GASilentp.T1251T1
DAPK1READchr99025285990252859GAMissense_Mutationp.V96I1
DAPK1BLCAchr99029640790296407GAMissense_Mutation1
DAPK1SKCMchr99031196190311961CTMissense_Mutationp.P818L1
DAPK1HNSCchr99032137590321375GAMissense_Mutationp.R1155H1
DAPK1STADchr99032220690322206GAMissense_Mutationp.G1407D1
DAPK1COADchr99026652290266522CTSilentp.F569F1
DAPK1SARCchr99032107490321074CTNonsense_Mutation1
DAPK1KIRCchr99032165290321652CTSilentp.V1222V1
DAPK1LUSCchr99031366290313662GASilentp.E901E1
DAPK1SARCchr99026089290260892GTMissense_Mutation1
DAPK1CESCchr99030151590301515GASilentp.V7581
DAPK1LIHCchr99026655390266553C-Frame_Shift_Delp.P580fs1
DAPK1COADchr99032185090321850CTSilentp.H1288H1
DAPK1SKCMchr99025527390255273CASilentp.S230S1
DAPK1GBMchr99025837790258377TCSilent1
DAPK1KIRPchr99030161790301617CASilent1
DAPK1LIHCchr99026230090262300T-Frame_Shift_Delp.P437fs1
DAPK1HNSCchr99031365090313650GTSilentp.P897P1
DAPK1UCECchr99026376790263767CTSilentp.F467F1
DAPK1LGGchr99027295090272950CTNonsense_Mutation1
DAPK1LUADchr99032202890322028GTMissense_Mutationp.G1373W1
DAPK1BLCAchr99028355690283556GCMissense_Mutation1
DAPK1CESCchr99021992090219920GASilent1
DAPK1ESCAchr99032212190322121A-Frame_Shift_Delp.K1404fs1
DAPK1SKCMchr99032209190322091CTMissense_Mutationp.P1394S1
DAPK1HNSCchr99031799190317991GTSilentp.L998L1
DAPK1COADchr99029641590296415A-Frame_Shift_Delp.G699fs1
DAPK1SARCchr99028351290283512GAMissense_Mutationp.D642N1
DAPK1ESCAchr99022007990220079GTSilentp.L91L1
DAPK1LIHCchr99026231290262312AGSilent1
DAPK1LUSCchr99029647890296478CTMissense_Mutationp.P721S1
DAPK1SARCchr99021988090219880CTMissense_Mutation1
DAPK1BLCAchr99027296590272965CTMissense_Mutationp.L616F1
DAPK1LUADchr99026369490263694ATSplice_Site1
DAPK1PRADchr99032139490321394CGMissense_Mutationp.H1136Q1
DAPK1BLCAchr99025291390252913GAMissense_Mutation1
DAPK1BLCAchr99025457690254576GCMissense_Mutationp.V189L1
DAPK1DLBCchr99021990790219907GTMissense_Mutationp.S34I1
DAPK1SKCMchr99032208490322084CTSilentp.T1366T1
DAPK1HNSCchr99031365090313650GTSilent1
DAPK1STADchr99025290390252904TT-Frame_Shift_Delp.S110fs1
DAPK1KIRPchr99032144790321447GTMissense_Mutation1
DAPK1LIHCchr99031507090315070T-Frame_Shift_Delp.V930fs1
DAPK1UCECchr99032152890321528CTMissense_Mutationp.A1181V1
DAPK1LGGchr99027303290273032CTMissense_Mutation1
DAPK1LUADchr99032163590321635ACMissense_Mutationp.S1242R1
DAPK1SARCchr99030153990301539GTMissense_Mutation1
DAPK1BLCAchr99026655890266558CTSilent1
DAPK1SKCMchr99032204590322045CTSilentp.F1378F1
DAPK1COADchr99029647690296476GAMissense_Mutationp.R720Q1
DAPK1ESCAchr99031197490311974CTSilentp.C822C1
DAPK1LUSCchr99031207990312079CGSilentp.L857L1
DAPK1BLCAchr99026226590262265GCMissense_Mutationp.D426H1
DAPK1LUADchr99032113790321137GAMissense_Mutationp.V1076M1
DAPK1BLCAchr99027296590272965CTMissense_Mutation1
DAPK1BLCAchr99031801890318018CGSilentp.P1007P1
DAPK1DLBCchr99032129390321293GAMissense_Mutationp.V1103I1
DAPK1HNSCchr99032133890321338GAMissense_Mutation1
DAPK1STADchr99025436890254368A-Frame_Shift_Delp.F174fs1
DAPK1THCAchr99032202390322023GAMissense_Mutation1
DAPK1KIRPchr99032187290321872CAMissense_Mutation1
DAPK1LIHCchr99011401290114012A-Frame_Shift_Delp.E7fs1
DAPK1UCECchr99025534390255343ACSilentp.R254R1
DAPK1LGGchr99031359390313593CTSilent1
DAPK1LUADchr99026378190263781ACMissense_Mutationp.N472T1
DAPK1SARCchr99026659890266598GTMissense_Mutation1
DAPK1BLCAchr99026228090262280CGMissense_Mutation1
DAPK1CESCchr99026501590265015CTSilent1
DAPK1SKCMchr99022007690220076CTSilentp.I90I1
DAPK1HNSCchr99025286590252865GTMissense_Mutationp.G98C1
DAPK1COADchr99030159390301593GASilentp.P784P1
DAPK1SKCMchr99032140690321406CTSilentp.F1140F1
DAPK1ESCAchr99032118190321181CTSilentp.T1065T1
DAPK1STADchr99032138690321386GAMissense_Mutationp.V1134M1
DAPK1KIRCchr99029635390296353GAMissense_Mutationp.R679Q1
DAPK1LIHCchr99031803690318036GASilentp.L988L1
DAPK1MESOchr99032162890321628GTSilent1
DAPK1BLCAchr99025427290254272GCMissense_Mutationp.E143Q1
DAPK1LUADchr99031357690313576GTMissense_Mutationp.G873C1
DAPK1PRADchr99032162490321624AGMissense_Mutationp.D1238G1
DAPK1BLCAchr99026226590262265GCMissense_Mutation1
DAPK1SKCMchr99032152090321520CTSilentp.N1203N1
DAPK1HNSCchr99031799190317991GTSilent1
DAPK1STADchr99025290390252904TT-Frame_Shift_Delp.110_110del1
DAPK1THCAchr99029635290296352CTNonsense_Mutationp.R679X1
DAPK1HNSCchr99032194390321943GASilentp.P1344P1
DAPK1LGGchr99031510790315107GTMissense_Mutation1
DAPK1LUADchr99031503090315037AGGTTTGG-Splice_Sitep.917_splice1
DAPK1SARCchr99031199090311990GTMissense_Mutation1
DAPK1BLCAchr99026498090264980GAMissense_Mutation1
DAPK1SKCMchr99032227290322272CTMissense_Mutationp.S1454F1
DAPK1HNSCchr99011399690113996AGMissense_Mutationp.T2A1
DAPK1BLCAchr99026501390265013GCMissense_Mutationp.D536H1
DAPK1COADchr99032113690321136CTSilentp.S1050S1
DAPK1ESCAchr99032198690321986TGMissense_Mutationp.L1334V1
DAPK1KIRCchr99025835490258354AGMissense_Mutationp.M328V1
DAPK1LIHCchr99021988890219888A-Frame_Shift_Delp.V27fs1
DAPK1LIHCchr99025526490255264A-Frame_Shift_Delp.A227fs1
DAPK1MESOchr99026484990264849CAMissense_Mutation1
DAPK1LUADchr99032156990321569GCMissense_Mutationp.E1220Q1
DAPK1PRADchr99029653290296532ATNonsense_Mutationp.K739*1
DAPK1BLCAchr99025427290254272GCMissense_Mutation1
DAPK1SKCMchr99032208490322084CTSilentp.T1391T1
DAPK1HNSCchr99032204990322049CTMissense_Mutation1
DAPK1THYMchr99032176190321761CTMissense_Mutation1
DAPK1LGGchr99032202790322027CTSilentp.N1372N1
DAPK1HNSCchr99032133890321338GAMissense_Mutationp.D1118N1
DAPK1UCECchr99030158190301581GASilentp.P780P1
DAPK1LUADchr99032108090321080G-Frame_Shift_Delp.V1057fs1
DAPK1SARCchr99031508490315084GTMissense_Mutation1
DAPK1BLCAchr99026224890262248CTMissense_Mutation1
DAPK1BLCAchr99025692390256923GAMissense_Mutationp.A290T1
DAPK1COADchr99021997990219979GAMissense_Mutationp.R58H1
DAPK1COADchr99032123990321239CAMissense_Mutationp.L1085I1
DAPK1ESCAchr99032118190321181CTSilentp.T1090T1
DAPK1KIRCchr99032165290321652CTSilentp.V1247V1
DAPK1LIHCchr99029640390296403TCMissense_Mutationp.S696P1
DAPK1LIHCchr99025693890256938A-Frame_Shift_Delp.K295fs1
DAPK1OVchr99031205290312052CTSilentp.I8481
DAPK1BLCAchr99026501390265013GCMissense_Mutation1
DAPK1ESCAchr99032118190321181CTSilentp.T10901
DAPK1SKCMchr99032140690321406CTSilentp.F1165F1
DAPK1HNSCchr99032194390321943GASilent1
DAPK1HNSCchr99032213090322130GAMissense_Mutationp.E1407K1
DAPK1THYMchr99032185090321850CAMissense_Mutationp.H1288Q1
DAPK1LGGchr99025294490252944TAMissense_Mutationp.L124H1
DAPK1HNSCchr99031799190317991GTSilentp.L973L1
DAPK1UCECchr99031200790312007GTSilentp.T833T1
DAPK1LGGchr99025294490252944TAMissense_Mutation1
DAPK1UVMchr99032155790321557GAMissense_Mutationp.G1191S1
DAPK1LUADchr99025575290255752CGMissense_Mutationp.P273R1
DAPK1BLCAchr99025457690254576GCMissense_Mutation1
DAPK1ESCAchr99032180190321802--Frame_Shift_Ins1
DAPK1SKCMchr99032180290321802G-Frame_Shift_Delp.M1297fs1
DAPK1BLCAchr99032109990321099GAMissense_Mutationp.R1063H1
DAPK1SKCMchr99032152090321520CTSilentp.N1178N1
DAPK1LIHCchr99029652190296521CTMissense_Mutationp.P735L1
DAPK1LIHCchr99026085090260850C-Frame_Shift_Delp.A351fs1
DAPK1LUADchr99025522390255223GCMissense_Mutationp.A214P1
DAPK1BLCAchr99025692390256923GAMissense_Mutation1
DAPK1SKCMchr99032163190321631GASilentp.V1240V1
DAPK1THYMchr99026137690261376CTMissense_Mutationp.H378Y1
DAPK1LGGchr99031359390313593CTSilentp.N878N1
DAPK1HNSCchr99032194390321943GASilentp.P1319P1
DAPK1UCECchr99026498190264981AGMissense_Mutationp.D525G1
DAPK1LGGchr99032164490321644GTNonsense_Mutation1
DAPK1LUADchr99032202890322028GTMissense_Mutationp.G1348W1
DAPK1SARCchr99026373890263738GTMissense_Mutation1
DAPK1BLCAchr99031801890318018CGSilent1
DAPK1CESCchr99028351490283514CTSilent1
DAPK1SARCchr99031508490315084GTMissense_Mutationp.A935S1
DAPK1STADchr99026492490264950TCAAGAACCGAGAAGGAGAGACGCCCC-In_Frame_Del1
DAPK1COADchr99032147590321475CTSilentp.G1163G1
DAPK1ESCAchr99032206590322065CTMissense_Mutation1
DAPK1LIHCchr99030157790301577C-Frame_Shift_Delp.A779fs1
DAPK1PAADchr99025830090258300CTMissense_Mutation1
DAPK1PRADchr99032139490321394CGMissense_Mutationp.H1161Q1
DAPK1BLCAchr99032109990321099GAMissense_Mutation1
DAPK1ESCAchr99032170090321700C-Frame_Shift_Delp.Q1265fs1
DAPK1SKCMchr99031803290318032CTMissense_Mutationp.S1012L1
DAPK1HNSCchr99025286590252865GTMissense_Mutation1
DAPK1HNSCchr99032204990322049CTMissense_Mutationp.P1380S1
DAPK1THYMchr99031366290313662GTMissense_Mutationp.E901D1
DAPK1LGGchr99031510790315107GTMissense_Mutationp.K942N1
DAPK1UCECchr99025696190256962-AFrame_Shift_Insp.R302fs1
DAPK1LGGchr99032227490322274CASilent1
DAPK1LUADchr99031503090315037AGGTTTGG-Splice_Sitep.R917_splice1
DAPK1SARCchr99029640590296405GASilent1
DAPK1COADchr99025522390255223GAMissense_Mutationp.A214T1
DAPK1ESCAchr99031197490311974CTSilent1
DAPK1STADchr99032180290321802G-Frame_Shift_Del1

check buttonCopy number variation (CNV) of DAPK1
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across DAPK1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
102858SARCTCGA-K1-A6RU-01AAGTPBP1chr988356690-DAPK1chr990252858+
89658LUADTCGA-86-8075-01ADAPK1chr990114054+AGTPBP1chr988236200-
75863N/AAI051167DAPK1chr990149183+ARL6IP5chr369155217-
96510N/AEC582481DAPK1chr990138255-C11orf80chr1166564197+
102858N/ABF368862DAPK1chr990140117-DAPK1chr990139967+
92587N/ABE737723DAPK1chr990140491+EML1chr14100303358-
83874N/ABI495211DAPK1chr990169342-GCOM1chr1558009753-
93324N/ABF994061DAPK1chr990117527-GRIA3chrX122437509-
102330BRCATCGA-B6-A0I8-01ADAPK1chr990296541+GRIN2Dchr1948922842+
84019N/ABC003614DAPK1chr990260886+MAMDC2chr972832516+
70820Non-CancerTCGA-CG-5730-11ADAPK1chr990114054+NFIL3chr994173188-
60214N/AW79389DAPK1chr990140269-NRBP1chr227662728-
96051N/ABI049651DAPK1chr990163342+RBM5chr350145518-
21356N/AEI704264DAPK1chr990161976+RP11-410D17.2chr1658903281+
57943KIRPTCGA-UZ-A9PQ-01ADAPK1chr990273042+WSCD1chr175792077+
102858N/ABI494742DNERchr2230222345-DAPK1chr990168146-
102858N/AAV699194MTRNR2L12chr396037546-DAPK1chr990186346+
102858STADTCGA-BR-8364-01ARAPGEF1chr9134615157-DAPK1chr990219869+
102858KIRCTCGA-B8-A8YJ-01ASPIN1chr991003453-DAPK1chr990283512+
102858BRCATCGA-AO-A0J2-01ATGDSchr1395248305-DAPK1chr990321047+
102858KIRPTCGA-UZ-A9PQ-01AWSCD1chr175792150+DAPK1chr990283512+
102863BRCATCGA-E2-A1LG-01AZNF738chr1921558766+DAPK1chr990311922+


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
HNSCDAPK10.0004967029923986280.014
LIHCDAPK10.0006268981144053810.017
BLCADAPK10.01649339146846520.43
BRCADAPK10.02151016664190380.54
LGGDAPK10.02368718925463150.57
LUSCDAPK10.02709822408999140.62

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
THCADAPK10.0479106573977891
KIRPDAPK10.00593094841951450.19
LGGDAPK12.48975819407262e-078.2e-06
BRCADAPK10.008656311158489820.27
ESCADAPK10.01277447027205430.38
THYMDAPK10.02006919644510160.58

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
P53355DB040695,6-Dihydro-Benzo[H]Cinnolin-3-YlamineSmall moleculeExperimental
P53355DB04395Phosphoaminophosphonic Acid-Adenylate EsterSmall moleculeExperimental
P53355DB074446-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONESmall moleculeExperimental
P53355DB040695,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine
P53355DB04395Phosphoaminophosphonic Acid-Adenylate Ester
P53355DB074446-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source
C0007131Non-Small Cell Lung Carcinoma1CTD_human
C0007134Renal Cell Carcinoma1CTD_human
C0007138Carcinoma, Transitional Cell1CTD_human
C0010606Adenoid Cystic Carcinoma1CTD_human
C0023467Leukemia, Myelocytic, Acute1CTD_human
C0026998Acute Myeloid Leukemia, M11CTD_human
C0087031Juvenile-Onset Still Disease1CTD_human
C0153633Malignant neoplasm of brain1CTD_human
C0205641Adenocarcinoma, Basal Cell1CTD_human
C0205642Adenocarcinoma, Oxyphilic1CTD_human
C0205643Carcinoma, Cribriform1CTD_human
C0205644Carcinoma, Granular Cell1CTD_human
C0205645Adenocarcinoma, Tubular1CTD_human
C0220636Malignant neoplasm of salivary gland1CTD_human
C0242379Malignant neoplasm of lung1CTD_human
C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
C0496899Benign neoplasm of brain, unspecified1CTD_human
C0750974Brain Tumor, Primary1CTD_human
C0750977Recurrent Brain Neoplasm1CTD_human
C0750979Primary malignant neoplasm of brain1CTD_human
C0877578Treatment related secondary malignancy1CTD_human
C1266042Chromophobe Renal Cell Carcinoma1CTD_human
C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
C1306837Papillary Renal Cell Carcinoma1CTD_human
C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
C3495559Juvenile arthritis1CTD_human
C3714758Juvenile psoriatic arthritis1CTD_human
C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human