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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: DHX36 (NCBI Gene ID:170506)

Gene Summary

Gene Summary

Gene Information	Gene Name: DHX36
	Gene ID: 170506
	Gene Symbol	DHX36
	Gene ID	170506
	Gene Name	DEAH-box helicase 36
	Synonyms	DDX36\|G4R1\|MLEL1\|RHAU
	Cytomap	3q25.2
	Type of Gene	protein-coding
	Description	ATP-dependent DNA/RNA helicase DHX36ATP-dependent RNA helicase DHX36DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36DEAD/H box polypeptide 36DEAH (Asp-Glu-Ala-His) box polypeptide 36DEAH box protein 36G4 resolvase-1MLE-like protein 1RNA helicase as
	Modification date	20200313
	UniProtAcc	Q9H2U1

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DHX36	GO:0010501	RNA secondary structure unwinding	18842585\|20472641\|21149580\|21846770\|22238380
Hgene	DHX36	GO:0017148	negative regulation of translation	24369427
Hgene	DHX36	GO:0034605	cellular response to heat	18854321
Hgene	DHX36	GO:0044806	G-quadruplex DNA unwinding	16150737\|18842585
Hgene	DHX36	GO:0090669	telomerase RNA stabilization	22238380
Hgene	DHX36	GO:1903843	cellular response to arsenite ion	18854321

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
DHX36	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'DHX36[title] AND translation [title] AND human.'

Gene	Title	PMID
DHX36	The RNA helicase DHX36-G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat-associated translation	34174288

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000496811	153998551	153998651	Frame-shift
ENST00000496811	154002371	154002458	In-frame
ENST00000496811	154006654	154006753	In-frame
ENST00000496811	154017626	154017714	Frame-shift
ENST00000496811	154018775	154018916	In-frame
ENST00000496811	154029424	154029463	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000496811	154002371	154002458	6750	2287	2373	1008	735	764
ENST00000496811	154006654	154006753	6750	2014	2112	1008	644	677
ENST00000496811	154018775	154018916	6750	1299	1439	1008	406	452
ENST00000496811	154029424	154029463	6750	685	723	1008	201	214

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9H2U1	735	764	1	1008	Chain	ID=PRO_0000247530;Note=ATP-dependent DNA/RNA helicase DHX36
Q9H2U1	406	452	1	1008	Chain	ID=PRO_0000247530;Note=ATP-dependent DNA/RNA helicase DHX36
Q9H2U1	644	677	1	1008	Chain	ID=PRO_0000247530;Note=ATP-dependent DNA/RNA helicase DHX36
Q9H2U1	201	214	1	1008	Chain	ID=PRO_0000247530;Note=ATP-dependent DNA/RNA helicase DHX36
Q9H2U1	644	677	477	647	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00542
Q9H2U1	201	214	106	386	Region	Note=RecA-like domain 1;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05B79
Q9H2U1	406	452	387	628	Region	Note=RecA-like domain 2;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05B79
Q9H2U1	644	677	629	698	Region	Note=WH domain;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05B79
Q9H2U1	644	677	638	697	Region	Note=Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q05B79
Q9H2U1	735	764	737	765	Alternative sequence	ID=VSP_020007;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9H2U1	406	452	416	416	Natural variant	ID=VAR_027141;Note=S->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:12198572,ECO:0000269\|PubMed:14731398,ECO:0000269\|PubMed:15489334;Dbxref=dbSNP:rs9438,PMID:12198572,PMID:14731398,PMID:15489334

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
COAD	DHX36	-1.04683304730666	0.00390031933784485

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
PRAD	DHX36	0.07825476	0.01007602

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with DHX36 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	DHX36	UGCG	0.806496196	4.55E-12
DLBC	Cell metabolism gene	DHX36	LMAN1	0.830054976	3.01E-13
DLBC	Cell metabolism gene	DHX36	PIK3CA	0.851225355	1.80E-14
DLBC	Cell metabolism gene	DHX36	PIK3R4	0.856120757	8.80E-15
DLBC	CGC	DHX36	PIK3CA	0.851225355	1.80E-14
DLBC	CGC	DHX36	STAG1	0.854667646	1.09E-14
DLBC	CGC	DHX36	ATR	0.881528344	1.34E-16
DLBC	Epifactor	DHX36	PPP4R2	0.800936976	8.18E-12
DLBC	Epifactor	DHX36	ADNP	0.80110934	8.04E-12
DLBC	Epifactor	DHX36	SHPRH	0.806154788	4.72E-12
DLBC	Epifactor	DHX36	EPC1	0.812462843	2.37E-12
DLBC	Epifactor	DHX36	SETD5	0.814239287	1.94E-12
DLBC	Epifactor	DHX36	SMARCAD1	0.832956704	2.10E-13
DLBC	Epifactor	DHX36	ATR	0.881528344	1.34E-16
DLBC	IUPHAR	DHX36	HIPK3	0.801275392	7.90E-12
DLBC	IUPHAR	DHX36	NEK4	0.804078058	5.89E-12
DLBC	IUPHAR	DHX36	DPP8	0.8056007	5.01E-12
DLBC	IUPHAR	DHX36	UGCG	0.806496196	4.55E-12
DLBC	IUPHAR	DHX36	ADAM17	0.808066399	3.84E-12
DLBC	IUPHAR	DHX36	TNKS2	0.820898419	9.07E-13
DLBC	IUPHAR	DHX36	ATP11B	0.822278663	7.71E-13
DLBC	IUPHAR	DHX36	ADAM10	0.826800231	4.49E-13
DLBC	IUPHAR	DHX36	ERN1	0.829196881	3.35E-13
DLBC	IUPHAR	DHX36	PIK3CA	0.851225355	1.80E-14
DLBC	IUPHAR	DHX36	NR2C2	0.854316751	1.15E-14
DLBC	IUPHAR	DHX36	PIK3R4	0.856120757	8.80E-15
DLBC	IUPHAR	DHX36	SLC33A1	0.869956792	1.00E-15
DLBC	IUPHAR	DHX36	ATR	0.881528344	1.34E-16
DLBC	Kinase	DHX36	HIPK3	0.801275392	7.90E-12
DLBC	Kinase	DHX36	NEK4	0.804078058	5.89E-12
DLBC	Kinase	DHX36	ERN1	0.829196881	3.35E-13
DLBC	Kinase	DHX36	PIK3R4	0.856120757	8.80E-15
DLBC	Kinase	DHX36	ATR	0.881528344	1.34E-16
DLBC	TF	DHX36	ZNF699	0.800848893	8.26E-12
DLBC	TF	DHX36	ADNP	0.80110934	8.04E-12
DLBC	TF	DHX36	ZNF281	0.807192945	4.22E-12
DLBC	TF	DHX36	TMF1	0.808804231	3.55E-12
DLBC	TF	DHX36	ZBTB11	0.825203871	5.44E-13
DLBC	TF	DHX36	ETV3	0.826528687	4.64E-13
DLBC	TF	DHX36	HIVEP1	0.8345052	1.72E-13
DLBC	TF	DHX36	NR2C2	0.854316751	1.15E-14
DLBC	TF	DHX36	RREB1	0.878483982	2.32E-16
DLBC	TSG	DHX36	EAF1	0.801913043	7.39E-12
DLBC	TSG	DHX36	SHPRH	0.806154788	4.72E-12
DLBC	TSG	DHX36	HIVEP1	0.8345052	1.72E-13
DLBC	TSG	DHX36	NR2C2	0.854316751	1.15E-14
DLBC	TSG	DHX36	ATR	0.881528344	1.34E-16
KICH	Cell metabolism gene	DHX36	TOMM70A	0.803532953	9.28E-22
KICH	Epifactor	DHX36	PHC3	0.802884835	1.06E-21
KICH	TF	DHX36	ZNF148	0.832366465	1.55E-24
KICH	TSG	DHX36	PHC3	0.802884835	1.06E-21
KICH	TSG	DHX36	DLG1	0.860414154	8.57E-28
LAML	TSG	DHX36	DLG1	0.805273664	1.14E-40
PCPG	Cell metabolism gene	DHX36	PIK3R4	0.807136551	3.29E-44
PCPG	IUPHAR	DHX36	PIK3R4	0.807136551	3.29E-44
PCPG	Kinase	DHX36	PIK3R4	0.807136551	3.29E-44
SKCM	Cell metabolism gene	DHX36	PIK3CA	0.861990436	2.30E-141
SKCM	CGC	DHX36	STAG1	0.808202682	1.31E-110
SKCM	CGC	DHX36	ATR	0.838926096	8.62E-127
SKCM	CGC	DHX36	PIK3CA	0.861990436	2.30E-141
SKCM	Epifactor	DHX36	SMARCA5	0.807227699	3.83E-110
SKCM	Epifactor	DHX36	HLTF	0.810221429	1.40E-111
SKCM	Epifactor	DHX36	ATR	0.838926096	8.62E-127
SKCM	IUPHAR	DHX36	PRKCI	0.812248346	1.44E-112
SKCM	IUPHAR	DHX36	ATR	0.838926096	8.62E-127
SKCM	IUPHAR	DHX36	MFN1	0.856071535	2.20E-137
SKCM	IUPHAR	DHX36	PIK3CA	0.861990436	2.30E-141
SKCM	Kinase	DHX36	PRKCI	0.812248346	1.44E-112
SKCM	Kinase	DHX36	ATR	0.838926096	8.62E-127
SKCM	TF	DHX36	ZNF148	0.844115723	7.33E-130
SKCM	TF	DHX36	MYNN	0.84980545	2.33E-133
SKCM	TF	DHX36	ZBTB11	0.859146504	1.98E-139
SKCM	TSG	DHX36	HLTF	0.810221429	1.40E-111
SKCM	TSG	DHX36	ECT2	0.812339488	1.30E-112
SKCM	TSG	DHX36	ATR	0.838926096	8.62E-127
THCA	Cell metabolism gene	DHX36	SEC24B	0.836049607	1.00E-150
THCA	CGC	DHX36	AFF4	0.800277668	1.03E-128
THCA	CGC	DHX36	LATS1	0.80254183	5.71E-130
THCA	CGC	DHX36	ASXL2	0.805823056	8.05E-132
THCA	CGC	DHX36	USP8	0.806789313	2.26E-132
THCA	CGC	DHX36	STAG1	0.842700157	2.09E-155
THCA	Epifactor	DHX36	EPC1	0.801956521	1.21E-129
THCA	Epifactor	DHX36	SMEK2	0.803519506	1.62E-130
THCA	Epifactor	DHX36	ASH1L	0.804239333	6.36E-131
THCA	Epifactor	DHX36	ASXL2	0.805823056	8.05E-132
THCA	Epifactor	DHX36	DDX21	0.806687599	2.58E-132
THCA	Epifactor	DHX36	TAF2	0.814591828	6.04E-137
THCA	Epifactor	DHX36	USP12	0.827604844	4.48E-145
THCA	Epifactor	DHX36	PPP4R2	0.831428277	1.36E-147
THCA	Epifactor	DHX36	ATF2	0.844157901	1.84E-156
THCA	IUPHAR	DHX36	LATS1	0.80254183	5.71E-130
THCA	IUPHAR	DHX36	ADAM10	0.802542209	5.71E-130
THCA	IUPHAR	DHX36	USP1	0.803596014	1.47E-130
THCA	IUPHAR	DHX36	ASH1L	0.804239333	6.36E-131
THCA	IUPHAR	DHX36	DPP8	0.805099887	2.07E-131
THCA	IUPHAR	DHX36	SLC25A40	0.81493243	3.77E-137
THCA	IUPHAR	DHX36	SLK	0.816890397	2.47E-138
THCA	IUPHAR	DHX36	HIPK3	0.816891817	2.46E-138
THCA	IUPHAR	DHX36	MAP3K2	0.827185683	8.40E-145
THCA	IUPHAR	DHX36	TNKS2	0.838505273	1.98E-152
THCA	Kinase	DHX36	LATS1	0.80254183	5.71E-130
THCA	Kinase	DHX36	SLK	0.816890397	2.47E-138
THCA	Kinase	DHX36	HIPK3	0.816891817	2.46E-138
THCA	Kinase	DHX36	MAP3K2	0.827185683	8.40E-145
THCA	TF	DHX36	ASH1L	0.804239333	6.36E-131
THCA	TF	DHX36	ZBTB26	0.8100551	2.92E-134
THCA	TF	DHX36	TMF1	0.821473465	3.67E-141
THCA	TF	DHX36	ATF2	0.844157901	1.84E-156
THCA	TSG	DHX36	LATS1	0.80254183	5.71E-130
THCA	TSG	DHX36	RBL2	0.80307761	2.86E-130
THCA	TSG	DHX36	USP12	0.827604844	4.48E-145
THYM	Cell metabolism gene	DHX36	PAPSS1	0.800827865	1.73E-28
THYM	Cell metabolism gene	DHX36	ITPR3	0.801505867	1.44E-28
THYM	Cell metabolism gene	DHX36	DPYD	0.805920412	4.30E-29
THYM	Cell metabolism gene	DHX36	LONP2	0.806707158	3.46E-29
THYM	Cell metabolism gene	DHX36	ALG10B	0.808248738	2.25E-29
THYM	Cell metabolism gene	DHX36	MTMR1	0.809192188	1.72E-29
THYM	Cell metabolism gene	DHX36	SMG1	0.809208888	1.72E-29
THYM	Cell metabolism gene	DHX36	GXYLT1	0.812208136	7.30E-30
THYM	Cell metabolism gene	DHX36	SUCLA2	0.813011842	5.79E-30
THYM	Cell metabolism gene	DHX36	PIGK	0.815148452	3.11E-30
THYM	Cell metabolism gene	DHX36	TNPO1	0.815392549	2.89E-30
THYM	Cell metabolism gene	DHX36	GLUD2	0.817219063	1.69E-30
THYM	Cell metabolism gene	DHX36	ACADM	0.819499142	8.55E-31
THYM	Cell metabolism gene	DHX36	PHAX	0.822595201	3.34E-31
THYM	Cell metabolism gene	DHX36	SEC24B	0.825620932	1.31E-31
THYM	Cell metabolism gene	DHX36	MED23	0.82772228	6.77E-32
THYM	Cell metabolism gene	DHX36	GLS	0.828098304	6.01E-32
THYM	Cell metabolism gene	DHX36	BCKDHB	0.831634932	1.93E-32
THYM	Cell metabolism gene	DHX36	PIKFYVE	0.831939402	1.75E-32
THYM	Cell metabolism gene	DHX36	POLR2B	0.833404562	1.08E-32
THYM	Cell metabolism gene	DHX36	MED17	0.834199926	8.33E-33
THYM	Cell metabolism gene	DHX36	XRN2	0.835737182	5.00E-33
THYM	Cell metabolism gene	DHX36	PATL1	0.837372036	2.89E-33
THYM	Cell metabolism gene	DHX36	SYNJ1	0.838313851	2.10E-33
THYM	Cell metabolism gene	DHX36	CDK8	0.840905108	8.64E-34
THYM	Cell metabolism gene	DHX36	TRMT11	0.841843484	6.24E-34
THYM	Cell metabolism gene	DHX36	SEC24D	0.843563267	3.42E-34
THYM	Cell metabolism gene	DHX36	MAT2B	0.8453958	1.78E-34
THYM	Cell metabolism gene	DHX36	COL4A3BP	0.848441609	5.95E-35
THYM	Cell metabolism gene	DHX36	RQCD1	0.856684925	2.69E-36
THYM	Cell metabolism gene	DHX36	PIP5K1A	0.860378801	6.29E-37
THYM	Cell metabolism gene	DHX36	ARFGEF2	0.86192867	3.38E-37
THYM	Cell metabolism gene	DHX36	MTM1	0.862553148	2.62E-37
THYM	Cell metabolism gene	DHX36	NCOA6	0.863958	1.48E-37
THYM	Cell metabolism gene	DHX36	RANBP2	0.86832701	2.39E-38
THYM	Cell metabolism gene	DHX36	NUP153	0.872571757	3.82E-39
THYM	Cell metabolism gene	DHX36	MANEA	0.873327992	2.73E-39
THYM	Cell metabolism gene	DHX36	MUT	0.880489122	1.04E-40
THYM	Cell metabolism gene	DHX36	PNPLA8	0.898314555	1.11E-44
THYM	Cell metabolism gene	DHX36	PIK3CA	0.899442172	5.88E-45
THYM	Cell metabolism gene	DHX36	AASDHPPT	0.906593017	8.74E-47
THYM	Cell metabolism gene	DHX36	PIK3R4	0.930882416	2.59E-54
THYM	CGC	DHX36	SF3B1	0.802299152	1.16E-28
THYM	CGC	DHX36	KTN1	0.805768551	4.49E-29
THYM	CGC	DHX36	GOPC	0.806477236	3.69E-29
THYM	CGC	DHX36	ATRX	0.810908997	1.06E-29
THYM	CGC	DHX36	PTPN11	0.817706584	1.46E-30
THYM	CGC	DHX36	CDC73	0.818990064	9.96E-31
THYM	CGC	DHX36	CHD2	0.823408693	2.60E-31
THYM	CGC	DHX36	ATF1	0.827211804	7.95E-32
THYM	CGC	DHX36	ZCCHC8	0.827960842	6.27E-32
THYM	CGC	DHX36	FBXO11	0.833727755	9.73E-33
THYM	CGC	DHX36	RB1	0.835047304	6.29E-33
THYM	CGC	DHX36	NSD1	0.839475931	1.41E-33
THYM	CGC	DHX36	DICER1	0.840766598	9.06E-34
THYM	CGC	DHX36	AFF4	0.843288469	3.76E-34
THYM	CGC	DHX36	MAPK1	0.859100511	1.04E-36
THYM	CGC	DHX36	FUBP1	0.863500157	1.79E-37
THYM	CGC	DHX36	BIRC6	0.864688214	1.10E-37
THYM	CGC	DHX36	NUP98	0.86542063	8.10E-38
THYM	CGC	DHX36	RANBP2	0.86832701	2.39E-38
THYM	CGC	DHX36	ATR	0.891721086	3.93E-43
THYM	CGC	DHX36	MLLT10	0.897766526	1.51E-44
THYM	CGC	DHX36	PIK3CA	0.899442172	5.88E-45
THYM	CGC	DHX36	STAG1	0.908590426	2.54E-47
THYM	Epifactor	DHX36	DDX21	0.800363861	1.96E-28
THYM	Epifactor	DHX36	YY1	0.800570915	1.85E-28
THYM	Epifactor	DHX36	ARID4A	0.801789617	1.33E-28
THYM	Epifactor	DHX36	SF3B1	0.802299152	1.16E-28
THYM	Epifactor	DHX36	USP12	0.802605984	1.07E-28
THYM	Epifactor	DHX36	MPHOSPH8	0.802766337	1.02E-28
THYM	Epifactor	DHX36	CUL2	0.806103505	4.09E-29
THYM	Epifactor	DHX36	WAC	0.807653557	2.66E-29
THYM	Epifactor	DHX36	MGA	0.810904871	1.06E-29
THYM	Epifactor	DHX36	ATRX	0.810908997	1.06E-29
THYM	Epifactor	DHX36	BRWD1	0.811112116	9.99E-30
THYM	Epifactor	DHX36	RNF2	0.814155301	4.15E-30
THYM	Epifactor	DHX36	PHF2	0.814217365	4.08E-30
THYM	Epifactor	DHX36	ZZZ3	0.816781372	1.92E-30
THYM	Epifactor	DHX36	TET3	0.817133511	1.73E-30
THYM	Epifactor	DHX36	TAF1	0.818205057	1.26E-30
THYM	Epifactor	DHX36	CDC73	0.818990064	9.96E-31
THYM	Epifactor	DHX36	INO80D	0.820771343	5.82E-31
THYM	Epifactor	DHX36	CHD2	0.823408693	2.60E-31
THYM	Epifactor	DHX36	ZRANB3	0.824429609	1.90E-31
THYM	Epifactor	DHX36	C11orf30	0.826662528	9.45E-32
THYM	Epifactor	DHX36	KDM3A	0.827958387	6.28E-32
THYM	Epifactor	DHX36	PPP4R2	0.82856413	5.18E-32
THYM	Epifactor	DHX36	MBD5	0.829017637	4.48E-32
THYM	Epifactor	DHX36	YEATS2	0.829567265	3.76E-32
THYM	Epifactor	DHX36	UBE2H	0.829636418	3.68E-32
THYM	Epifactor	DHX36	BPTF	0.832175333	1.62E-32
THYM	Epifactor	DHX36	BRPF3	0.833287284	1.12E-32
THYM	Epifactor	DHX36	RBBP5	0.834160961	8.44E-33
THYM	Epifactor	DHX36	RB1	0.835047304	6.29E-33
THYM	Epifactor	DHX36	EPC2	0.837665032	2.62E-33
THYM	Epifactor	DHX36	REST	0.83777298	2.52E-33
THYM	Epifactor	DHX36	CTR9	0.837869152	2.44E-33
THYM	Epifactor	DHX36	NSD1	0.839475931	1.41E-33
THYM	Epifactor	DHX36	RLIM	0.839855336	1.24E-33
THYM	Epifactor	DHX36	ATF2	0.840207777	1.10E-33
THYM	Epifactor	DHX36	GLYR1	0.842656044	4.70E-34
THYM	Epifactor	DHX36	SIRT1	0.844880854	2.14E-34
THYM	Epifactor	DHX36	EPC1	0.846473116	1.21E-34
THYM	Epifactor	DHX36	AEBP2	0.847713246	7.76E-35
THYM	Epifactor	DHX36	HLTF	0.848046183	6.87E-35
THYM	Epifactor	DHX36	TADA2A	0.848074554	6.80E-35
THYM	Epifactor	DHX36	PHF8	0.849263854	4.41E-35
THYM	Epifactor	DHX36	SHPRH	0.851169107	2.18E-35
THYM	Epifactor	DHX36	SMARCA5	0.852428244	1.36E-35
THYM	Epifactor	DHX36	KDM3B	0.853151589	1.04E-35
THYM	Epifactor	DHX36	MAP3K7	0.854134259	7.15E-36
THYM	Epifactor	DHX36	PHC3	0.856805298	2.56E-36
THYM	Epifactor	DHX36	NCOA6	0.863958	1.48E-37
THYM	Epifactor	DHX36	HCFC2	0.86455523	1.16E-37
THYM	Epifactor	DHX36	SMEK2	0.87148837	6.14E-39
THYM	Epifactor	DHX36	SMARCAD1	0.879328274	1.79E-40
THYM	Epifactor	DHX36	ZNF217	0.8798849	1.38E-40
THYM	Epifactor	DHX36	ADNP	0.882424609	4.14E-41
THYM	Epifactor	DHX36	ATR	0.891721086	3.93E-43
THYM	Epifactor	DHX36	JMJD1C	0.894253192	1.03E-43
THYM	Epifactor	DHX36	MLLT10	0.897766526	1.51E-44
THYM	Epifactor	DHX36	TAF2	0.89923354	6.61E-45
THYM	IUPHAR	DHX36	ITPR3	0.801505867	1.44E-28
THYM	IUPHAR	DHX36	SLC35A3	0.802971254	9.68E-29
THYM	IUPHAR	DHX36	SLC39A10	0.803449603	8.50E-29
THYM	IUPHAR	DHX36	ATP7A	0.803972246	7.36E-29
THYM	IUPHAR	DHX36	ADAM10	0.805273213	5.15E-29
THYM	IUPHAR	DHX36	DPYD	0.805920412	4.30E-29
THYM	IUPHAR	DHX36	SLC25A24	0.806333804	3.84E-29
THYM	IUPHAR	DHX36	SMG1	0.809208888	1.72E-29
THYM	IUPHAR	DHX36	BRWD1	0.811112116	9.99E-30
THYM	IUPHAR	DHX36	TMEM30A	0.812385981	6.93E-30
THYM	IUPHAR	DHX36	PHF2	0.814217365	4.08E-30
THYM	IUPHAR	DHX36	TAF1	0.818205057	1.26E-30
THYM	IUPHAR	DHX36	SENP6	0.818449724	1.17E-30
THYM	IUPHAR	DHX36	PREPL	0.82328277	2.71E-31
THYM	IUPHAR	DHX36	SLC25A36	0.825887013	1.21E-31
THYM	IUPHAR	DHX36	SENP7	0.826889584	8.80E-32
THYM	IUPHAR	DHX36	KDM3A	0.827958387	6.28E-32
THYM	IUPHAR	DHX36	GLS	0.828098304	6.01E-32
THYM	IUPHAR	DHX36	SLC38A7	0.830181857	3.09E-32
THYM	IUPHAR	DHX36	ADAM17	0.831060198	2.32E-32
THYM	IUPHAR	DHX36	NEK1	0.831343622	2.12E-32
THYM	IUPHAR	DHX36	PIKFYVE	0.831939402	1.75E-32
THYM	IUPHAR	DHX36	BPTF	0.832175333	1.62E-32
THYM	IUPHAR	DHX36	BRPF3	0.833287284	1.12E-32
THYM	IUPHAR	DHX36	NEK7	0.833456419	1.06E-32
THYM	IUPHAR	DHX36	FBXO11	0.833727755	9.73E-33
THYM	IUPHAR	DHX36	MAP4K3	0.837626025	2.65E-33
THYM	IUPHAR	DHX36	SYNJ1	0.838313851	2.10E-33
THYM	IUPHAR	DHX36	NSD1	0.839475931	1.41E-33
THYM	IUPHAR	DHX36	SCYL2	0.840889723	8.69E-34
THYM	IUPHAR	DHX36	CDK8	0.840905108	8.64E-34
THYM	IUPHAR	DHX36	MFN1	0.843049851	4.09E-34
THYM	IUPHAR	DHX36	SIRT1	0.844880854	2.14E-34
THYM	IUPHAR	DHX36	PHF8	0.849263854	4.41E-35
THYM	IUPHAR	DHX36	KDM3B	0.853151589	1.04E-35
THYM	IUPHAR	DHX36	MAP3K7	0.854134259	7.15E-36
THYM	IUPHAR	DHX36	MAPK1	0.859100511	1.04E-36
THYM	IUPHAR	DHX36	PIP5K1A	0.860378801	6.29E-37
THYM	IUPHAR	DHX36	TNKS	0.862064002	3.20E-37
THYM	IUPHAR	DHX36	ATP13A3	0.862638685	2.54E-37
THYM	IUPHAR	DHX36	SLC10A7	0.864136443	1.38E-37
THYM	IUPHAR	DHX36	BIRC6	0.864688214	1.10E-37
THYM	IUPHAR	DHX36	PDPK1	0.869792288	1.28E-38
THYM	IUPHAR	DHX36	PKN2	0.871399764	6.38E-39
THYM	IUPHAR	DHX36	SLC30A5	0.874336554	1.75E-39
THYM	IUPHAR	DHX36	MAPK8	0.876991511	5.26E-40
THYM	IUPHAR	DHX36	NEK4	0.879931601	1.35E-40
THYM	IUPHAR	DHX36	SLK	0.890790241	6.38E-43
THYM	IUPHAR	DHX36	ATR	0.891721086	3.93E-43
THYM	IUPHAR	DHX36	JMJD1C	0.894253192	1.03E-43
THYM	IUPHAR	DHX36	TNKS2	0.898431822	1.04E-44
THYM	IUPHAR	DHX36	NR2C2	0.898597128	9.46E-45
THYM	IUPHAR	DHX36	PIK3CA	0.899442172	5.88E-45
THYM	IUPHAR	DHX36	PIK3R4	0.930882416	2.59E-54
THYM	Kinase	DHX36	SMG1	0.809208888	1.72E-29
THYM	Kinase	DHX36	TAF1	0.818205057	1.26E-30
THYM	Kinase	DHX36	NEK1	0.831343622	2.12E-32
THYM	Kinase	DHX36	NEK7	0.833456419	1.06E-32
THYM	Kinase	DHX36	MAP4K3	0.837626025	2.65E-33
THYM	Kinase	DHX36	SCYL2	0.840889723	8.69E-34
THYM	Kinase	DHX36	CDK8	0.840905108	8.64E-34
THYM	Kinase	DHX36	COL4A3BP	0.848441609	5.95E-35
THYM	Kinase	DHX36	MAP3K7	0.854134259	7.15E-36
THYM	Kinase	DHX36	MAPK1	0.859100511	1.04E-36
THYM	Kinase	DHX36	PDPK1	0.869792288	1.28E-38
THYM	Kinase	DHX36	PKN2	0.871399764	6.38E-39
THYM	Kinase	DHX36	MAPK8	0.876991511	5.26E-40
THYM	Kinase	DHX36	NEK4	0.879931601	1.35E-40
THYM	Kinase	DHX36	SLK	0.890790241	6.38E-43
THYM	Kinase	DHX36	ATR	0.891721086	3.93E-43
THYM	Kinase	DHX36	PIK3R4	0.930882416	2.59E-54
THYM	TF	DHX36	YY1	0.800570915	1.85E-28
THYM	TF	DHX36	ZBTB1	0.801099877	1.61E-28
THYM	TF	DHX36	ZNF721	0.801742254	1.35E-28
THYM	TF	DHX36	RREB1	0.80357175	8.22E-29
THYM	TF	DHX36	IKZF5	0.803807423	7.70E-29
THYM	TF	DHX36	ZNF543	0.804900703	5.71E-29
THYM	TF	DHX36	ZNF347	0.80553498	4.79E-29
THYM	TF	DHX36	ZNF689	0.806163029	4.02E-29
THYM	TF	DHX36	ZBTB10	0.807255483	2.97E-29
THYM	TF	DHX36	ZNF17	0.807424412	2.83E-29
THYM	TF	DHX36	ZNF148	0.810017977	1.36E-29
THYM	TF	DHX36	FOXJ3	0.810816058	1.09E-29
THYM	TF	DHX36	ZNF664	0.810821254	1.09E-29
THYM	TF	DHX36	MGA	0.810904871	1.06E-29
THYM	TF	DHX36	ZNF782	0.81316453	5.54E-30
THYM	TF	DHX36	ZNF189	0.813659461	4.80E-30
THYM	TF	DHX36	ELK3	0.814366494	3.91E-30
THYM	TF	DHX36	ZNF548	0.814587834	3.66E-30
THYM	TF	DHX36	HIVEP1	0.815771122	2.59E-30
THYM	TF	DHX36	ZZZ3	0.816781372	1.92E-30
THYM	TF	DHX36	TET3	0.817133511	1.73E-30
THYM	TF	DHX36	ZNF134	0.817844221	1.40E-30
THYM	TF	DHX36	ZNF426	0.820633252	6.07E-31
THYM	TF	DHX36	ZNF614	0.82157545	4.56E-31
THYM	TF	DHX36	ZNF200	0.822807658	3.13E-31
THYM	TF	DHX36	ZNF281	0.825429837	1.39E-31
THYM	TF	DHX36	ATF1	0.827211804	7.95E-32
THYM	TF	DHX36	ZXDC	0.82966157	3.65E-32
THYM	TF	DHX36	ADNP2	0.829674906	3.63E-32
THYM	TF	DHX36	BPTF	0.832175333	1.62E-32
THYM	TF	DHX36	RLF	0.83446474	7.63E-33
THYM	TF	DHX36	ZNF644	0.834870725	6.67E-33
THYM	TF	DHX36	ZNF12	0.835256869	5.87E-33
THYM	TF	DHX36	RBAK	0.836020963	4.55E-33
THYM	TF	DHX36	REST	0.83777298	2.52E-33
THYM	TF	DHX36	ZBTB43	0.838041894	2.30E-33
THYM	TF	DHX36	MEF2A	0.838896856	1.72E-33
THYM	TF	DHX36	ATF2	0.840207777	1.10E-33
THYM	TF	DHX36	SP4	0.841907128	6.10E-34
THYM	TF	DHX36	GLYR1	0.842656044	4.70E-34
THYM	TF	DHX36	ZNF225	0.843829857	3.11E-34
THYM	TF	DHX36	ZNF461	0.84411195	2.82E-34
THYM	TF	DHX36	ZNF800	0.844488021	2.46E-34
THYM	TF	DHX36	JRKL	0.846773938	1.09E-34
THYM	TF	DHX36	AEBP2	0.847713246	7.76E-35
THYM	TF	DHX36	NFXL1	0.848554771	5.71E-35
THYM	TF	DHX36	ZNF813	0.849265429	4.40E-35
THYM	TF	DHX36	ZBTB39	0.850437224	2.86E-35
THYM	TF	DHX36	ZNF146	0.851734458	1.77E-35
THYM	TF	DHX36	ZNF468	0.851960381	1.62E-35
THYM	TF	DHX36	TMF1	0.851992265	1.60E-35
THYM	TF	DHX36	TOPORS	0.853208651	1.02E-35
THYM	TF	DHX36	ZNF611	0.854849572	5.44E-36
THYM	TF	DHX36	ZNF680	0.856557755	2.82E-36
THYM	TF	DHX36	ZNF765	0.856701434	2.67E-36
THYM	TF	DHX36	ZBTB11	0.860424568	6.18E-37
THYM	TF	DHX36	ZNF180	0.86124513	4.45E-37
THYM	TF	DHX36	ZFP30	0.862218269	3.01E-37
THYM	TF	DHX36	SP3	0.862756267	2.42E-37
THYM	TF	DHX36	BBX	0.86313372	2.07E-37
THYM	TF	DHX36	ZNF432	0.865789231	6.95E-38
THYM	TF	DHX36	ZNF430	0.86942195	1.50E-38
THYM	TF	DHX36	ZNF627	0.86953787	1.43E-38
THYM	TF	DHX36	ZNF304	0.87136704	6.47E-39
THYM	TF	DHX36	ZFX	0.87893167	2.15E-40
THYM	TF	DHX36	ZNF354B	0.879573315	1.60E-40
THYM	TF	DHX36	ZNF217	0.8798849	1.38E-40
THYM	TF	DHX36	ADNP	0.882424609	4.14E-41
THYM	TF	DHX36	ZNF136	0.883703521	2.23E-41
THYM	TF	DHX36	MYNN	0.885534721	9.12E-42
THYM	TF	DHX36	ZNF776	0.888897549	1.69E-42
THYM	TF	DHX36	ZNF420	0.893413241	1.61E-43
THYM	TF	DHX36	ZNF567	0.893985187	1.19E-43
THYM	TF	DHX36	NR2C2	0.898597128	9.46E-45
THYM	TF	DHX36	ZNF28	0.908507791	2.67E-47
THYM	TSG	DHX36	USP12	0.802605984	1.07E-28
THYM	TSG	DHX36	EAF1	0.80462858	6.15E-29
THYM	TSG	DHX36	PPM1A	0.805776354	4.48E-29
THYM	TSG	DHX36	CUL2	0.806103505	4.09E-29
THYM	TSG	DHX36	HIVEP1	0.815771122	2.59E-30
THYM	TSG	DHX36	PTPN11	0.817706584	1.46E-30
THYM	TSG	DHX36	TP53BP2	0.818364418	1.20E-30
THYM	TSG	DHX36	CDC73	0.818990064	9.96E-31
THYM	TSG	DHX36	KDM3A	0.827958387	6.28E-32
THYM	TSG	DHX36	RBL2	0.829690056	3.61E-32
THYM	TSG	DHX36	GORAB	0.83471906	7.01E-33
THYM	TSG	DHX36	RB1	0.835047304	6.29E-33
THYM	TSG	DHX36	DICER1	0.840766598	9.06E-34
THYM	TSG	DHX36	SIRT1	0.844880854	2.14E-34
THYM	TSG	DHX36	HLTF	0.848046183	6.87E-35
THYM	TSG	DHX36	SHPRH	0.851169107	2.18E-35
THYM	TSG	DHX36	HACE1	0.853141745	1.04E-35
THYM	TSG	DHX36	KDM3B	0.853151589	1.04E-35
THYM	TSG	DHX36	TOPORS	0.853208651	1.02E-35
THYM	TSG	DHX36	KRIT1	0.855602234	4.08E-36
THYM	TSG	DHX36	PHC3	0.856805298	2.56E-36
THYM	TSG	DHX36	USP33	0.865086255	9.30E-38
THYM	TSG	DHX36	NUP98	0.86542063	8.10E-38
THYM	TSG	DHX36	RCHY1	0.867946985	2.81E-38
THYM	TSG	DHX36	TANK	0.872193648	4.51E-39
THYM	TSG	DHX36	DLG1	0.872603602	3.76E-39
THYM	TSG	DHX36	RB1CC1	0.876281852	7.27E-40
THYM	TSG	DHX36	ATR	0.891721086	3.93E-43
THYM	TSG	DHX36	NR2C2	0.898597128	9.46E-45
UCEC	Cell metabolism gene	DHX36	PIK3R4	0.816498355	2.32E-49
UCEC	IUPHAR	DHX36	PIK3R4	0.816498355	2.32E-49
UCEC	Kinase	DHX36	PIK3R4	0.816498355	2.32E-49
UCS	Cell metabolism gene	DHX36	PAPSS1	0.800827865	1.73E-28
UCS	Cell metabolism gene	DHX36	ITPR3	0.801505867	1.44E-28
UCS	Cell metabolism gene	DHX36	DPYD	0.805920412	4.30E-29
UCS	Cell metabolism gene	DHX36	LONP2	0.806707158	3.46E-29
UCS	Cell metabolism gene	DHX36	ALG10B	0.808248738	2.25E-29
UCS	Cell metabolism gene	DHX36	MTMR1	0.809192188	1.72E-29
UCS	Cell metabolism gene	DHX36	SMG1	0.809208888	1.72E-29
UCS	Cell metabolism gene	DHX36	GXYLT1	0.812208136	7.30E-30
UCS	Cell metabolism gene	DHX36	SUCLA2	0.813011842	5.79E-30
UCS	Cell metabolism gene	DHX36	PIGK	0.815148452	3.11E-30
UCS	Cell metabolism gene	DHX36	TNPO1	0.815392549	2.89E-30
UCS	Cell metabolism gene	DHX36	GLUD2	0.817219063	1.69E-30
UCS	Cell metabolism gene	DHX36	ACADM	0.819499142	8.55E-31
UCS	Cell metabolism gene	DHX36	PHAX	0.822595201	3.34E-31
UCS	Cell metabolism gene	DHX36	SEC24B	0.825620932	1.31E-31
UCS	Cell metabolism gene	DHX36	MED23	0.82772228	6.77E-32
UCS	Cell metabolism gene	DHX36	GLS	0.828098304	6.01E-32
UCS	Cell metabolism gene	DHX36	BCKDHB	0.831634932	1.93E-32
UCS	Cell metabolism gene	DHX36	PIKFYVE	0.831939402	1.75E-32
UCS	Cell metabolism gene	DHX36	POLR2B	0.833404562	1.08E-32
UCS	Cell metabolism gene	DHX36	MED17	0.834199926	8.33E-33
UCS	Cell metabolism gene	DHX36	XRN2	0.835737182	5.00E-33
UCS	Cell metabolism gene	DHX36	PATL1	0.837372036	2.89E-33
UCS	Cell metabolism gene	DHX36	SYNJ1	0.838313851	2.10E-33
UCS	Cell metabolism gene	DHX36	CDK8	0.840905108	8.64E-34
UCS	Cell metabolism gene	DHX36	TRMT11	0.841843484	6.24E-34
UCS	Cell metabolism gene	DHX36	SEC24D	0.843563267	3.42E-34
UCS	Cell metabolism gene	DHX36	MAT2B	0.8453958	1.78E-34
UCS	Cell metabolism gene	DHX36	COL4A3BP	0.848441609	5.95E-35
UCS	Cell metabolism gene	DHX36	RQCD1	0.856684925	2.69E-36
UCS	Cell metabolism gene	DHX36	PIP5K1A	0.860378801	6.29E-37
UCS	Cell metabolism gene	DHX36	ARFGEF2	0.86192867	3.38E-37
UCS	Cell metabolism gene	DHX36	MTM1	0.862553148	2.62E-37
UCS	Cell metabolism gene	DHX36	NCOA6	0.863958	1.48E-37
UCS	Cell metabolism gene	DHX36	RANBP2	0.86832701	2.39E-38
UCS	Cell metabolism gene	DHX36	NUP153	0.872571757	3.82E-39
UCS	Cell metabolism gene	DHX36	MANEA	0.873327992	2.73E-39
UCS	Cell metabolism gene	DHX36	MUT	0.880489122	1.04E-40
UCS	Cell metabolism gene	DHX36	PNPLA8	0.898314555	1.11E-44
UCS	Cell metabolism gene	DHX36	PIK3CA	0.899442172	5.88E-45
UCS	Cell metabolism gene	DHX36	AASDHPPT	0.906593017	8.74E-47
UCS	Cell metabolism gene	DHX36	PIK3R4	0.930882416	2.59E-54
UCS	CGC	DHX36	SF3B1	0.802299152	1.16E-28
UCS	CGC	DHX36	KTN1	0.805768551	4.49E-29
UCS	CGC	DHX36	GOPC	0.806477236	3.69E-29
UCS	CGC	DHX36	ATRX	0.810908997	1.06E-29
UCS	CGC	DHX36	PTPN11	0.817706584	1.46E-30
UCS	CGC	DHX36	CDC73	0.818990064	9.96E-31
UCS	CGC	DHX36	CHD2	0.823408693	2.60E-31
UCS	CGC	DHX36	ATF1	0.827211804	7.95E-32
UCS	CGC	DHX36	ZCCHC8	0.827960842	6.27E-32
UCS	CGC	DHX36	FBXO11	0.833727755	9.73E-33
UCS	CGC	DHX36	RB1	0.835047304	6.29E-33
UCS	CGC	DHX36	NSD1	0.839475931	1.41E-33
UCS	CGC	DHX36	DICER1	0.840766598	9.06E-34
UCS	CGC	DHX36	AFF4	0.843288469	3.76E-34
UCS	CGC	DHX36	MAPK1	0.859100511	1.04E-36
UCS	CGC	DHX36	FUBP1	0.863500157	1.79E-37
UCS	CGC	DHX36	BIRC6	0.864688214	1.10E-37
UCS	CGC	DHX36	NUP98	0.86542063	8.10E-38
UCS	CGC	DHX36	RANBP2	0.86832701	2.39E-38
UCS	CGC	DHX36	ATR	0.891721086	3.93E-43
UCS	CGC	DHX36	MLLT10	0.897766526	1.51E-44
UCS	CGC	DHX36	PIK3CA	0.899442172	5.88E-45
UCS	CGC	DHX36	STAG1	0.908590426	2.54E-47
UCS	Epifactor	DHX36	DDX21	0.800363861	1.96E-28
UCS	Epifactor	DHX36	YY1	0.800570915	1.85E-28
UCS	Epifactor	DHX36	ARID4A	0.801789617	1.33E-28
UCS	Epifactor	DHX36	SF3B1	0.802299152	1.16E-28
UCS	Epifactor	DHX36	USP12	0.802605984	1.07E-28
UCS	Epifactor	DHX36	MPHOSPH8	0.802766337	1.02E-28
UCS	Epifactor	DHX36	CUL2	0.806103505	4.09E-29
UCS	Epifactor	DHX36	WAC	0.807653557	2.66E-29
UCS	Epifactor	DHX36	MGA	0.810904871	1.06E-29
UCS	Epifactor	DHX36	ATRX	0.810908997	1.06E-29
UCS	Epifactor	DHX36	BRWD1	0.811112116	9.99E-30
UCS	Epifactor	DHX36	RNF2	0.814155301	4.15E-30
UCS	Epifactor	DHX36	PHF2	0.814217365	4.08E-30
UCS	Epifactor	DHX36	ZZZ3	0.816781372	1.92E-30
UCS	Epifactor	DHX36	TET3	0.817133511	1.73E-30
UCS	Epifactor	DHX36	TAF1	0.818205057	1.26E-30
UCS	Epifactor	DHX36	CDC73	0.818990064	9.96E-31
UCS	Epifactor	DHX36	INO80D	0.820771343	5.82E-31
UCS	Epifactor	DHX36	CHD2	0.823408693	2.60E-31
UCS	Epifactor	DHX36	ZRANB3	0.824429609	1.90E-31
UCS	Epifactor	DHX36	C11orf30	0.826662528	9.45E-32
UCS	Epifactor	DHX36	KDM3A	0.827958387	6.28E-32
UCS	Epifactor	DHX36	PPP4R2	0.82856413	5.18E-32
UCS	Epifactor	DHX36	MBD5	0.829017637	4.48E-32
UCS	Epifactor	DHX36	YEATS2	0.829567265	3.76E-32
UCS	Epifactor	DHX36	UBE2H	0.829636418	3.68E-32
UCS	Epifactor	DHX36	BPTF	0.832175333	1.62E-32
UCS	Epifactor	DHX36	BRPF3	0.833287284	1.12E-32
UCS	Epifactor	DHX36	RBBP5	0.834160961	8.44E-33
UCS	Epifactor	DHX36	RB1	0.835047304	6.29E-33
UCS	Epifactor	DHX36	EPC2	0.837665032	2.62E-33
UCS	Epifactor	DHX36	REST	0.83777298	2.52E-33
UCS	Epifactor	DHX36	CTR9	0.837869152	2.44E-33
UCS	Epifactor	DHX36	NSD1	0.839475931	1.41E-33
UCS	Epifactor	DHX36	RLIM	0.839855336	1.24E-33
UCS	Epifactor	DHX36	ATF2	0.840207777	1.10E-33
UCS	Epifactor	DHX36	GLYR1	0.842656044	4.70E-34
UCS	Epifactor	DHX36	SIRT1	0.844880854	2.14E-34
UCS	Epifactor	DHX36	EPC1	0.846473116	1.21E-34
UCS	Epifactor	DHX36	AEBP2	0.847713246	7.76E-35
UCS	Epifactor	DHX36	HLTF	0.848046183	6.87E-35
UCS	Epifactor	DHX36	TADA2A	0.848074554	6.80E-35
UCS	Epifactor	DHX36	PHF8	0.849263854	4.41E-35
UCS	Epifactor	DHX36	SHPRH	0.851169107	2.18E-35
UCS	Epifactor	DHX36	SMARCA5	0.852428244	1.36E-35
UCS	Epifactor	DHX36	KDM3B	0.853151589	1.04E-35
UCS	Epifactor	DHX36	MAP3K7	0.854134259	7.15E-36
UCS	Epifactor	DHX36	PHC3	0.856805298	2.56E-36
UCS	Epifactor	DHX36	NCOA6	0.863958	1.48E-37
UCS	Epifactor	DHX36	HCFC2	0.86455523	1.16E-37
UCS	Epifactor	DHX36	SMEK2	0.87148837	6.14E-39
UCS	Epifactor	DHX36	SMARCAD1	0.879328274	1.79E-40
UCS	Epifactor	DHX36	ZNF217	0.8798849	1.38E-40
UCS	Epifactor	DHX36	ADNP	0.882424609	4.14E-41
UCS	Epifactor	DHX36	ATR	0.891721086	3.93E-43
UCS	Epifactor	DHX36	JMJD1C	0.894253192	1.03E-43
UCS	Epifactor	DHX36	MLLT10	0.897766526	1.51E-44
UCS	Epifactor	DHX36	TAF2	0.89923354	6.61E-45
UCS	IUPHAR	DHX36	ITPR3	0.801505867	1.44E-28
UCS	IUPHAR	DHX36	SLC35A3	0.802971254	9.68E-29
UCS	IUPHAR	DHX36	SLC39A10	0.803449603	8.50E-29
UCS	IUPHAR	DHX36	ATP7A	0.803972246	7.36E-29
UCS	IUPHAR	DHX36	ADAM10	0.805273213	5.15E-29
UCS	IUPHAR	DHX36	DPYD	0.805920412	4.30E-29
UCS	IUPHAR	DHX36	SLC25A24	0.806333804	3.84E-29
UCS	IUPHAR	DHX36	SMG1	0.809208888	1.72E-29
UCS	IUPHAR	DHX36	BRWD1	0.811112116	9.99E-30
UCS	IUPHAR	DHX36	TMEM30A	0.812385981	6.93E-30
UCS	IUPHAR	DHX36	PHF2	0.814217365	4.08E-30
UCS	IUPHAR	DHX36	TAF1	0.818205057	1.26E-30
UCS	IUPHAR	DHX36	SENP6	0.818449724	1.17E-30
UCS	IUPHAR	DHX36	PREPL	0.82328277	2.71E-31
UCS	IUPHAR	DHX36	SLC25A36	0.825887013	1.21E-31
UCS	IUPHAR	DHX36	SENP7	0.826889584	8.80E-32
UCS	IUPHAR	DHX36	KDM3A	0.827958387	6.28E-32
UCS	IUPHAR	DHX36	GLS	0.828098304	6.01E-32
UCS	IUPHAR	DHX36	SLC38A7	0.830181857	3.09E-32
UCS	IUPHAR	DHX36	ADAM17	0.831060198	2.32E-32
UCS	IUPHAR	DHX36	NEK1	0.831343622	2.12E-32
UCS	IUPHAR	DHX36	PIKFYVE	0.831939402	1.75E-32
UCS	IUPHAR	DHX36	BPTF	0.832175333	1.62E-32
UCS	IUPHAR	DHX36	BRPF3	0.833287284	1.12E-32
UCS	IUPHAR	DHX36	NEK7	0.833456419	1.06E-32
UCS	IUPHAR	DHX36	FBXO11	0.833727755	9.73E-33
UCS	IUPHAR	DHX36	MAP4K3	0.837626025	2.65E-33
UCS	IUPHAR	DHX36	SYNJ1	0.838313851	2.10E-33
UCS	IUPHAR	DHX36	NSD1	0.839475931	1.41E-33
UCS	IUPHAR	DHX36	SCYL2	0.840889723	8.69E-34
UCS	IUPHAR	DHX36	CDK8	0.840905108	8.64E-34
UCS	IUPHAR	DHX36	MFN1	0.843049851	4.09E-34
UCS	IUPHAR	DHX36	SIRT1	0.844880854	2.14E-34
UCS	IUPHAR	DHX36	PHF8	0.849263854	4.41E-35
UCS	IUPHAR	DHX36	KDM3B	0.853151589	1.04E-35
UCS	IUPHAR	DHX36	MAP3K7	0.854134259	7.15E-36
UCS	IUPHAR	DHX36	MAPK1	0.859100511	1.04E-36
UCS	IUPHAR	DHX36	PIP5K1A	0.860378801	6.29E-37
UCS	IUPHAR	DHX36	TNKS	0.862064002	3.20E-37
UCS	IUPHAR	DHX36	ATP13A3	0.862638685	2.54E-37
UCS	IUPHAR	DHX36	SLC10A7	0.864136443	1.38E-37
UCS	IUPHAR	DHX36	BIRC6	0.864688214	1.10E-37
UCS	IUPHAR	DHX36	PDPK1	0.869792288	1.28E-38
UCS	IUPHAR	DHX36	PKN2	0.871399764	6.38E-39
UCS	IUPHAR	DHX36	SLC30A5	0.874336554	1.75E-39
UCS	IUPHAR	DHX36	MAPK8	0.876991511	5.26E-40
UCS	IUPHAR	DHX36	NEK4	0.879931601	1.35E-40
UCS	IUPHAR	DHX36	SLK	0.890790241	6.38E-43
UCS	IUPHAR	DHX36	ATR	0.891721086	3.93E-43
UCS	IUPHAR	DHX36	JMJD1C	0.894253192	1.03E-43
UCS	IUPHAR	DHX36	TNKS2	0.898431822	1.04E-44
UCS	IUPHAR	DHX36	NR2C2	0.898597128	9.46E-45
UCS	IUPHAR	DHX36	PIK3CA	0.899442172	5.88E-45
UCS	IUPHAR	DHX36	PIK3R4	0.930882416	2.59E-54
UCS	Kinase	DHX36	SMG1	0.809208888	1.72E-29
UCS	Kinase	DHX36	TAF1	0.818205057	1.26E-30
UCS	Kinase	DHX36	NEK1	0.831343622	2.12E-32
UCS	Kinase	DHX36	NEK7	0.833456419	1.06E-32
UCS	Kinase	DHX36	MAP4K3	0.837626025	2.65E-33
UCS	Kinase	DHX36	SCYL2	0.840889723	8.69E-34
UCS	Kinase	DHX36	CDK8	0.840905108	8.64E-34
UCS	Kinase	DHX36	COL4A3BP	0.848441609	5.95E-35
UCS	Kinase	DHX36	MAP3K7	0.854134259	7.15E-36
UCS	Kinase	DHX36	MAPK1	0.859100511	1.04E-36
UCS	Kinase	DHX36	PDPK1	0.869792288	1.28E-38
UCS	Kinase	DHX36	PKN2	0.871399764	6.38E-39
UCS	Kinase	DHX36	MAPK8	0.876991511	5.26E-40
UCS	Kinase	DHX36	NEK4	0.879931601	1.35E-40
UCS	Kinase	DHX36	SLK	0.890790241	6.38E-43
UCS	Kinase	DHX36	ATR	0.891721086	3.93E-43
UCS	Kinase	DHX36	PIK3R4	0.930882416	2.59E-54
UCS	TF	DHX36	YY1	0.800570915	1.85E-28
UCS	TF	DHX36	ZBTB1	0.801099877	1.61E-28
UCS	TF	DHX36	ZNF721	0.801742254	1.35E-28
UCS	TF	DHX36	RREB1	0.80357175	8.22E-29
UCS	TF	DHX36	IKZF5	0.803807423	7.70E-29
UCS	TF	DHX36	ZNF543	0.804900703	5.71E-29
UCS	TF	DHX36	ZNF347	0.80553498	4.79E-29
UCS	TF	DHX36	ZNF689	0.806163029	4.02E-29
UCS	TF	DHX36	ZBTB10	0.807255483	2.97E-29
UCS	TF	DHX36	ZNF17	0.807424412	2.83E-29
UCS	TF	DHX36	ZNF148	0.810017977	1.36E-29
UCS	TF	DHX36	FOXJ3	0.810816058	1.09E-29
UCS	TF	DHX36	ZNF664	0.810821254	1.09E-29
UCS	TF	DHX36	MGA	0.810904871	1.06E-29
UCS	TF	DHX36	ZNF782	0.81316453	5.54E-30
UCS	TF	DHX36	ZNF189	0.813659461	4.80E-30
UCS	TF	DHX36	ELK3	0.814366494	3.91E-30
UCS	TF	DHX36	ZNF548	0.814587834	3.66E-30
UCS	TF	DHX36	HIVEP1	0.815771122	2.59E-30
UCS	TF	DHX36	ZZZ3	0.816781372	1.92E-30
UCS	TF	DHX36	TET3	0.817133511	1.73E-30
UCS	TF	DHX36	ZNF134	0.817844221	1.40E-30
UCS	TF	DHX36	ZNF426	0.820633252	6.07E-31
UCS	TF	DHX36	ZNF614	0.82157545	4.56E-31
UCS	TF	DHX36	ZNF200	0.822807658	3.13E-31
UCS	TF	DHX36	ZNF281	0.825429837	1.39E-31
UCS	TF	DHX36	ATF1	0.827211804	7.95E-32
UCS	TF	DHX36	ZXDC	0.82966157	3.65E-32
UCS	TF	DHX36	ADNP2	0.829674906	3.63E-32
UCS	TF	DHX36	BPTF	0.832175333	1.62E-32
UCS	TF	DHX36	RLF	0.83446474	7.63E-33
UCS	TF	DHX36	ZNF644	0.834870725	6.67E-33
UCS	TF	DHX36	ZNF12	0.835256869	5.87E-33
UCS	TF	DHX36	RBAK	0.836020963	4.55E-33
UCS	TF	DHX36	REST	0.83777298	2.52E-33
UCS	TF	DHX36	ZBTB43	0.838041894	2.30E-33
UCS	TF	DHX36	MEF2A	0.838896856	1.72E-33
UCS	TF	DHX36	ATF2	0.840207777	1.10E-33
UCS	TF	DHX36	SP4	0.841907128	6.10E-34
UCS	TF	DHX36	GLYR1	0.842656044	4.70E-34
UCS	TF	DHX36	ZNF225	0.843829857	3.11E-34
UCS	TF	DHX36	ZNF461	0.84411195	2.82E-34
UCS	TF	DHX36	ZNF800	0.844488021	2.46E-34
UCS	TF	DHX36	JRKL	0.846773938	1.09E-34
UCS	TF	DHX36	AEBP2	0.847713246	7.76E-35
UCS	TF	DHX36	NFXL1	0.848554771	5.71E-35
UCS	TF	DHX36	ZNF813	0.849265429	4.40E-35
UCS	TF	DHX36	ZBTB39	0.850437224	2.86E-35
UCS	TF	DHX36	ZNF146	0.851734458	1.77E-35
UCS	TF	DHX36	ZNF468	0.851960381	1.62E-35
UCS	TF	DHX36	TMF1	0.851992265	1.60E-35
UCS	TF	DHX36	TOPORS	0.853208651	1.02E-35
UCS	TF	DHX36	ZNF611	0.854849572	5.44E-36
UCS	TF	DHX36	ZNF680	0.856557755	2.82E-36
UCS	TF	DHX36	ZNF765	0.856701434	2.67E-36
UCS	TF	DHX36	ZBTB11	0.860424568	6.18E-37
UCS	TF	DHX36	ZNF180	0.86124513	4.45E-37
UCS	TF	DHX36	ZFP30	0.862218269	3.01E-37
UCS	TF	DHX36	SP3	0.862756267	2.42E-37
UCS	TF	DHX36	BBX	0.86313372	2.07E-37
UCS	TF	DHX36	ZNF432	0.865789231	6.95E-38
UCS	TF	DHX36	ZNF430	0.86942195	1.50E-38
UCS	TF	DHX36	ZNF627	0.86953787	1.43E-38
UCS	TF	DHX36	ZNF304	0.87136704	6.47E-39
UCS	TF	DHX36	ZFX	0.87893167	2.15E-40
UCS	TF	DHX36	ZNF354B	0.879573315	1.60E-40
UCS	TF	DHX36	ZNF217	0.8798849	1.38E-40
UCS	TF	DHX36	ADNP	0.882424609	4.14E-41
UCS	TF	DHX36	ZNF136	0.883703521	2.23E-41
UCS	TF	DHX36	MYNN	0.885534721	9.12E-42
UCS	TF	DHX36	ZNF776	0.888897549	1.69E-42
UCS	TF	DHX36	ZNF420	0.893413241	1.61E-43
UCS	TF	DHX36	ZNF567	0.893985187	1.19E-43
UCS	TF	DHX36	NR2C2	0.898597128	9.46E-45
UCS	TF	DHX36	ZNF28	0.908507791	2.67E-47
UCS	TSG	DHX36	USP12	0.802605984	1.07E-28
UCS	TSG	DHX36	EAF1	0.80462858	6.15E-29
UCS	TSG	DHX36	PPM1A	0.805776354	4.48E-29
UCS	TSG	DHX36	CUL2	0.806103505	4.09E-29
UCS	TSG	DHX36	HIVEP1	0.815771122	2.59E-30
UCS	TSG	DHX36	PTPN11	0.817706584	1.46E-30
UCS	TSG	DHX36	TP53BP2	0.818364418	1.20E-30
UCS	TSG	DHX36	CDC73	0.818990064	9.96E-31
UCS	TSG	DHX36	KDM3A	0.827958387	6.28E-32
UCS	TSG	DHX36	RBL2	0.829690056	3.61E-32
UCS	TSG	DHX36	GORAB	0.83471906	7.01E-33
UCS	TSG	DHX36	RB1	0.835047304	6.29E-33
UCS	TSG	DHX36	DICER1	0.840766598	9.06E-34
UCS	TSG	DHX36	SIRT1	0.844880854	2.14E-34
UCS	TSG	DHX36	HLTF	0.848046183	6.87E-35
UCS	TSG	DHX36	SHPRH	0.851169107	2.18E-35
UCS	TSG	DHX36	HACE1	0.853141745	1.04E-35
UCS	TSG	DHX36	KDM3B	0.853151589	1.04E-35
UCS	TSG	DHX36	TOPORS	0.853208651	1.02E-35
UCS	TSG	DHX36	KRIT1	0.855602234	4.08E-36
UCS	TSG	DHX36	PHC3	0.856805298	2.56E-36
UCS	TSG	DHX36	USP33	0.865086255	9.30E-38
UCS	TSG	DHX36	NUP98	0.86542063	8.10E-38
UCS	TSG	DHX36	RCHY1	0.867946985	2.81E-38
UCS	TSG	DHX36	TANK	0.872193648	4.51E-39
UCS	TSG	DHX36	DLG1	0.872603602	3.76E-39
UCS	TSG	DHX36	RB1CC1	0.876281852	7.27E-40
UCS	TSG	DHX36	ATR	0.891721086	3.93E-43
UCS	TSG	DHX36	NR2C2	0.898597128	9.46E-45
UVM	Cell metabolism gene	DHX36	SLC44A1	0.800963138	4.69E-19
UVM	Cell metabolism gene	DHX36	PPP1CB	0.802503229	3.57E-19
UVM	Cell metabolism gene	DHX36	EDEM1	0.805621111	2.05E-19
UVM	Cell metabolism gene	DHX36	ACSL4	0.807230567	1.53E-19
UVM	Cell metabolism gene	DHX36	B4GALT4	0.807892913	1.36E-19
UVM	Cell metabolism gene	DHX36	DBT	0.80794704	1.34E-19
UVM	Cell metabolism gene	DHX36	SUCLG2	0.808704863	1.17E-19
UVM	Cell metabolism gene	DHX36	NUP54	0.811509777	6.95E-20
UVM	Cell metabolism gene	DHX36	MED21	0.813712955	4.60E-20
UVM	Cell metabolism gene	DHX36	IDI1	0.813857334	4.47E-20
UVM	Cell metabolism gene	DHX36	DCP1A	0.814769163	3.76E-20
UVM	Cell metabolism gene	DHX36	CSGALNACT2	0.820622339	1.21E-20
UVM	Cell metabolism gene	DHX36	GPCPD1	0.829940023	1.83E-21
UVM	Cell metabolism gene	DHX36	GPAM	0.834965759	6.27E-22
UVM	Cell metabolism gene	DHX36	PNPLA8	0.841308806	1.54E-22
UVM	Cell metabolism gene	DHX36	AASDHPPT	0.842120733	1.29E-22
UVM	Cell metabolism gene	DHX36	AGPS	0.842687638	1.13E-22
UVM	Cell metabolism gene	DHX36	C1GALT1	0.845855643	5.44E-23
UVM	Cell metabolism gene	DHX36	GNB4	0.849429375	2.34E-23
UVM	Cell metabolism gene	DHX36	IPMK	0.851676375	1.36E-23
UVM	Cell metabolism gene	DHX36	GALNT1	0.863544736	6.67E-25
UVM	Cell metabolism gene	DHX36	TBL1XR1	0.865506509	3.94E-25
UVM	Cell metabolism gene	DHX36	FBXL3	0.868060183	1.96E-25
UVM	Cell metabolism gene	DHX36	CPOX	0.872096981	6.33E-26
UVM	Cell metabolism gene	DHX36	SACM1L	0.873236886	4.57E-26
UVM	Cell metabolism gene	DHX36	PIK3CA	0.913164581	3.89E-32
UVM	CGC	DHX36	ACVR2A	0.800755055	4.86E-19
UVM	CGC	DHX36	RGPD3	0.802954367	3.30E-19
UVM	CGC	DHX36	CREB1	0.803240292	3.14E-19
UVM	CGC	DHX36	ARHGAP5	0.803855203	2.81E-19
UVM	CGC	DHX36	MLLT10	0.814164804	4.22E-20
UVM	CGC	DHX36	VHL	0.814981084	3.61E-20
UVM	CGC	DHX36	MAP3K1	0.815806342	3.09E-20
UVM	CGC	DHX36	STAG2	0.815937986	3.01E-20
UVM	CGC	DHX36	SF3B1	0.816689412	2.61E-20
UVM	CGC	DHX36	MSH2	0.819062879	1.65E-20
UVM	CGC	DHX36	PBRM1	0.82610647	4.03E-21
UVM	CGC	DHX36	SUZ12	0.827029043	3.34E-21
UVM	CGC	DHX36	ERCC4	0.829042448	2.20E-21
UVM	CGC	DHX36	MALT1	0.833488593	8.62E-22
UVM	CGC	DHX36	DEK	0.852693082	1.06E-23
UVM	CGC	DHX36	TBL1XR1	0.865506509	3.94E-25
UVM	CGC	DHX36	PHF6	0.865800433	3.64E-25
UVM	CGC	DHX36	SETD2	0.867059468	2.59E-25
UVM	CGC	DHX36	STAG1	0.880384911	5.46E-27
UVM	CGC	DHX36	PALB2	0.88269882	2.67E-27
UVM	CGC	DHX36	PIK3CA	0.913164581	3.89E-32
UVM	CGC	DHX36	ATR	0.913965231	2.76E-32
UVM	Epifactor	DHX36	CUL5	0.801024512	4.64E-19
UVM	Epifactor	DHX36	SUV420H1	0.801501527	4.26E-19
UVM	Epifactor	DHX36	FAM175A	0.802733269	3.43E-19
UVM	Epifactor	DHX36	MBIP	0.803851294	2.81E-19
UVM	Epifactor	DHX36	EPC2	0.807061169	1.58E-19
UVM	Epifactor	DHX36	TADA1	0.811548864	6.90E-20
UVM	Epifactor	DHX36	KAT2B	0.812477923	5.80E-20
UVM	Epifactor	DHX36	CUL2	0.81283994	5.42E-20
UVM	Epifactor	DHX36	RMI1	0.813743207	4.57E-20
UVM	Epifactor	DHX36	MLLT10	0.814164804	4.22E-20
UVM	Epifactor	DHX36	RLIM	0.816169784	2.88E-20
UVM	Epifactor	DHX36	SF3B1	0.816689412	2.61E-20
UVM	Epifactor	DHX36	YEATS4	0.81699133	2.46E-20
UVM	Epifactor	DHX36	SIRT1	0.817076171	2.42E-20
UVM	Epifactor	DHX36	PBRM1	0.82610647	4.03E-21
UVM	Epifactor	DHX36	SUZ12	0.827029043	3.34E-21
UVM	Epifactor	DHX36	UBR2	0.832172761	1.14E-21
UVM	Epifactor	DHX36	SUV39H2	0.833029168	9.51E-22
UVM	Epifactor	DHX36	RNF2	0.836796917	4.21E-22
UVM	Epifactor	DHX36	UBE2D1	0.839754144	2.19E-22
UVM	Epifactor	DHX36	YY1	0.840221915	1.97E-22
UVM	Epifactor	DHX36	ATXN7	0.846861119	4.30E-23
UVM	Epifactor	DHX36	BMI1	0.848010399	3.28E-23
UVM	Epifactor	DHX36	DEK	0.852693082	1.06E-23
UVM	Epifactor	DHX36	TOP2B	0.853763001	8.18E-24
UVM	Epifactor	DHX36	MBD4	0.855248543	5.65E-24
UVM	Epifactor	DHX36	TBL1XR1	0.865506509	3.94E-25
UVM	Epifactor	DHX36	SETD2	0.867059468	2.59E-25
UVM	Epifactor	DHX36	PPP4R2	0.899091705	1.04E-29
UVM	Epifactor	DHX36	PHC3	0.907036149	4.94E-31
UVM	Epifactor	DHX36	ATR	0.913965231	2.76E-32
UVM	Epifactor	DHX36	HLTF	0.914764195	1.94E-32
UVM	IUPHAR	DHX36	ACVR2A	0.800755055	4.86E-19
UVM	IUPHAR	DHX36	SCYL2	0.800846933	4.78E-19
UVM	IUPHAR	DHX36	SLC44A1	0.800963138	4.69E-19
UVM	IUPHAR	DHX36	NEK4	0.80849558	1.21E-19
UVM	IUPHAR	DHX36	SLK	0.809717222	9.70E-20
UVM	IUPHAR	DHX36	SLC25A46	0.810516065	8.37E-20
UVM	IUPHAR	DHX36	KAT2B	0.812477923	5.80E-20
UVM	IUPHAR	DHX36	CSNK1G3	0.812703455	5.56E-20
UVM	IUPHAR	DHX36	IDI1	0.813857334	4.47E-20
UVM	IUPHAR	DHX36	MAP3K1	0.815806342	3.09E-20
UVM	IUPHAR	DHX36	SIRT1	0.817076171	2.42E-20
UVM	IUPHAR	DHX36	ATP13A3	0.81775235	2.12E-20
UVM	IUPHAR	DHX36	BIRC2	0.817770382	2.12E-20
UVM	IUPHAR	DHX36	SLC4A7	0.818919434	1.69E-20
UVM	IUPHAR	DHX36	TRPM7	0.825570943	4.50E-21
UVM	IUPHAR	DHX36	PBRM1	0.82610647	4.03E-21
UVM	IUPHAR	DHX36	PRPF4B	0.827543777	3.00E-21
UVM	IUPHAR	DHX36	RIOK3	0.829582681	1.97E-21
UVM	IUPHAR	DHX36	NR2C2	0.82977764	1.89E-21
UVM	IUPHAR	DHX36	ATP6V1A	0.82984389	1.86E-21
UVM	IUPHAR	DHX36	SLC35A3	0.831339666	1.36E-21
UVM	IUPHAR	DHX36	SUV39H2	0.833029168	9.51E-22
UVM	IUPHAR	DHX36	MALT1	0.833488593	8.62E-22
UVM	IUPHAR	DHX36	YES1	0.839803398	2.17E-22
UVM	IUPHAR	DHX36	SNRK	0.841043812	1.64E-22
UVM	IUPHAR	DHX36	SLC25A36	0.856089022	4.58E-24
UVM	IUPHAR	DHX36	PRKCI	0.863626701	6.53E-25
UVM	IUPHAR	DHX36	SETD2	0.867059468	2.59E-25
UVM	IUPHAR	DHX36	SLC25A24	0.867449709	2.32E-25
UVM	IUPHAR	DHX36	CRBN	0.874689825	3.00E-26
UVM	IUPHAR	DHX36	SENP7	0.881895032	3.43E-27
UVM	IUPHAR	DHX36	SLC33A1	0.885491595	1.10E-27
UVM	IUPHAR	DHX36	SLC35A5	0.885999439	9.36E-28
UVM	IUPHAR	DHX36	OXSR1	0.89398346	6.44E-29
UVM	IUPHAR	DHX36	RYK	0.896788835	2.39E-29
UVM	IUPHAR	DHX36	ATP11B	0.907162413	4.70E-31
UVM	IUPHAR	DHX36	PIK3CA	0.913164581	3.89E-32
UVM	IUPHAR	DHX36	ATR	0.913965231	2.76E-32
UVM	IUPHAR	DHX36	MFN1	0.922067614	6.80E-34
UVM	Kinase	DHX36	ACVR2A	0.800755055	4.86E-19
UVM	Kinase	DHX36	SCYL2	0.800846933	4.78E-19
UVM	Kinase	DHX36	ICK	0.805343058	2.15E-19
UVM	Kinase	DHX36	NEK4	0.80849558	1.21E-19
UVM	Kinase	DHX36	SLK	0.809717222	9.70E-20
UVM	Kinase	DHX36	CSNK1G3	0.812703455	5.56E-20
UVM	Kinase	DHX36	MAP3K1	0.815806342	3.09E-20
UVM	Kinase	DHX36	TRPM7	0.825570943	4.50E-21
UVM	Kinase	DHX36	PRPF4B	0.827543777	3.00E-21
UVM	Kinase	DHX36	RIOK3	0.829582681	1.97E-21
UVM	Kinase	DHX36	YES1	0.839803398	2.17E-22
UVM	Kinase	DHX36	SNRK	0.841043812	1.64E-22
UVM	Kinase	DHX36	PRKCI	0.863626701	6.53E-25
UVM	Kinase	DHX36	OXSR1	0.89398346	6.44E-29
UVM	Kinase	DHX36	RYK	0.896788835	2.39E-29
UVM	Kinase	DHX36	ATR	0.913965231	2.76E-32
UVM	TF	DHX36	ZNF268	0.80009004	5.46E-19
UVM	TF	DHX36	ZNF143	0.801088325	4.59E-19
UVM	TF	DHX36	THAP5	0.801318388	4.40E-19
UVM	TF	DHX36	UBP1	0.801435927	4.31E-19
UVM	TF	DHX36	ZNF613	0.803221373	3.15E-19
UVM	TF	DHX36	CREB1	0.803240292	3.14E-19
UVM	TF	DHX36	ZFX	0.803245933	3.13E-19
UVM	TF	DHX36	ZNF235	0.803909136	2.78E-19
UVM	TF	DHX36	ZNF844	0.805549681	2.07E-19
UVM	TF	DHX36	ZNF606	0.806040423	1.90E-19
UVM	TF	DHX36	ZNF616	0.807546888	1.44E-19
UVM	TF	DHX36	ZNF24	0.807823627	1.37E-19
UVM	TF	DHX36	ZNF600	0.807976904	1.34E-19
UVM	TF	DHX36	ZNF567	0.808022878	1.32E-19
UVM	TF	DHX36	ZNF770	0.809754844	9.63E-20
UVM	TF	DHX36	ZNF136	0.810104479	9.03E-20
UVM	TF	DHX36	ZNF701	0.811283366	7.25E-20
UVM	TF	DHX36	ZNF83	0.812034667	6.31E-20
UVM	TF	DHX36	ZNF559	0.814906926	3.67E-20
UVM	TF	DHX36	ZNF180	0.815161384	3.49E-20
UVM	TF	DHX36	ZNF718	0.815739208	3.13E-20
UVM	TF	DHX36	ZNF197	0.816775809	2.56E-20
UVM	TF	DHX36	ZNF354B	0.817818673	2.10E-20
UVM	TF	DHX36	ZNF283	0.8178459	2.08E-20
UVM	TF	DHX36	ZNF568	0.818107814	1.98E-20
UVM	TF	DHX36	SMAD5	0.820407588	1.26E-20
UVM	TF	DHX36	ZNF529	0.822609365	8.17E-21
UVM	TF	DHX36	ZNF420	0.823197511	7.26E-21
UVM	TF	DHX36	ZNF17	0.823278546	7.14E-21
UVM	TF	DHX36	ZNF28	0.82332157	7.08E-21
UVM	TF	DHX36	ZNF585A	0.823351675	7.04E-21
UVM	TF	DHX36	ZNF761	0.823706033	6.56E-21
UVM	TF	DHX36	ZNF587	0.825176645	4.87E-21
UVM	TF	DHX36	ZNF845	0.8258782	4.22E-21
UVM	TF	DHX36	ZNF791	0.826252348	3.91E-21
UVM	TF	DHX36	ZNF304	0.827365989	3.12E-21
UVM	TF	DHX36	ZFP14	0.827935389	2.77E-21
UVM	TF	DHX36	HBP1	0.828057454	2.70E-21
UVM	TF	DHX36	ZNF347	0.829512001	2.00E-21
UVM	TF	DHX36	NR2C2	0.82977764	1.89E-21
UVM	TF	DHX36	ZNF569	0.830993932	1.46E-21
UVM	TF	DHX36	ZNF670	0.833121514	9.32E-22
UVM	TF	DHX36	ZNF621	0.83487851	6.39E-22
UVM	TF	DHX36	ZNF354A	0.836278539	4.72E-22
UVM	TF	DHX36	ZNF550	0.836794071	4.21E-22
UVM	TF	DHX36	ZNF345	0.837597762	3.53E-22
UVM	TF	DHX36	BBX	0.837664246	3.48E-22
UVM	TF	DHX36	ZNF254	0.837698153	3.45E-22
UVM	TF	DHX36	ZNF41	0.83955025	2.29E-22
UVM	TF	DHX36	ZNF790	0.840098349	2.03E-22
UVM	TF	DHX36	YY1	0.840221915	1.97E-22
UVM	TF	DHX36	ZNF160	0.840334124	1.92E-22
UVM	TF	DHX36	ZNF765	0.841397185	1.51E-22
UVM	TF	DHX36	ZNF91	0.843509066	9.36E-23
UVM	TF	DHX36	ZNF432	0.843911177	8.54E-23
UVM	TF	DHX36	GABPA	0.844777405	6.99E-23
UVM	TF	DHX36	ZNF14	0.845450557	5.98E-23
UVM	TF	DHX36	ZNF615	0.84559263	5.79E-23
UVM	TF	DHX36	NFXL1	0.849131428	2.52E-23
UVM	TF	DHX36	ZNF558	0.850285299	1.91E-23
UVM	TF	DHX36	ZNF440	0.852550368	1.10E-23
UVM	TF	DHX36	SP3	0.852675204	1.07E-23
UVM	TF	DHX36	MBD4	0.855248543	5.65E-24
UVM	TF	DHX36	ZNF131	0.856317134	4.33E-24
UVM	TF	DHX36	ZBTB38	0.856804458	3.83E-24
UVM	TF	DHX36	ZNF525	0.859639614	1.86E-24
UVM	TF	DHX36	ZNF611	0.862911843	7.89E-25
UVM	TF	DHX36	SKIL	0.865188132	4.30E-25
UVM	TF	DHX36	ZNF776	0.865244166	4.23E-25
UVM	TF	DHX36	ZNF551	0.868971524	1.53E-25
UVM	TF	DHX36	ZNF320	0.869006125	1.51E-25
UVM	TF	DHX36	ZNF813	0.871620267	7.25E-26
UVM	TF	DHX36	ZNF627	0.874209344	3.45E-26
UVM	TF	DHX36	ZNF644	0.87815089	1.08E-26
UVM	TF	DHX36	TMF1	0.882256759	3.06E-27
UVM	TF	DHX36	ZNF614	0.882596753	2.76E-27
UVM	TF	DHX36	CGGBP1	0.884897745	1.33E-27
UVM	TF	DHX36	MYNN	0.903493984	1.98E-30
UVM	TF	DHX36	ZNF184	0.908090029	3.23E-31
UVM	TF	DHX36	ZNF639	0.909179381	2.07E-31
UVM	TF	DHX36	ZNF654	0.912763153	4.63E-32
UVM	TF	DHX36	ZBTB11	0.928402232	2.82E-35
UVM	TF	DHX36	ZNF148	0.935762027	4.72E-37
UVM	TSG	DHX36	DCLRE1A	0.800461557	5.12E-19
UVM	TSG	DHX36	CUL5	0.801024512	4.64E-19
UVM	TSG	DHX36	EAF1	0.806081246	1.88E-19
UVM	TSG	DHX36	ARL6IP5	0.808988168	1.11E-19
UVM	TSG	DHX36	VEZT	0.81116624	7.41E-20
UVM	TSG	DHX36	CUL2	0.81283994	5.42E-20
UVM	TSG	DHX36	VHL	0.814981084	3.61E-20
UVM	TSG	DHX36	USP33	0.816895241	2.51E-20
UVM	TSG	DHX36	SIRT1	0.817076171	2.42E-20
UVM	TSG	DHX36	MSH2	0.819062879	1.65E-20
UVM	TSG	DHX36	RCHY1	0.819518203	1.50E-20
UVM	TSG	DHX36	PBRM1	0.82610647	4.03E-21
UVM	TSG	DHX36	RBM5	0.826902546	3.43E-21
UVM	TSG	DHX36	SUZ12	0.827029043	3.34E-21
UVM	TSG	DHX36	HBP1	0.828057454	2.70E-21
UVM	TSG	DHX36	NR2C2	0.82977764	1.89E-21
UVM	TSG	DHX36	TANK	0.831933897	1.20E-21
UVM	TSG	DHX36	ECT2	0.851395207	1.46E-23
UVM	TSG	DHX36	MBD4	0.855248543	5.65E-24
UVM	TSG	DHX36	RANBP9	0.859109829	2.13E-24
UVM	TSG	DHX36	SKIL	0.865188132	4.30E-25
UVM	TSG	DHX36	PHF6	0.865800433	3.64E-25
UVM	TSG	DHX36	SETD2	0.867059468	2.59E-25
UVM	TSG	DHX36	PALB2	0.88269882	2.67E-27
UVM	TSG	DHX36	PHC3	0.907036149	4.94E-31
UVM	TSG	DHX36	ATR	0.913965231	2.76E-32
UVM	TSG	DHX36	HLTF	0.914764195	1.94E-32

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUAD	DHX36	DHX58	-1.72312462970692	0.000242671052720231
LUAD	DHX36	DDX3X	-1.62089915088929	0.000257795914027732
COAD	DHX36	DDX41	-2.7676342025359	0.000363647937774659
LUSC	DHX36	DDX21	1.21862192985583	0.000552086454522047
LUSC	DHX36	DDX3X	-2.36794436729211	0.000778331171335384
HNSC	DHX36	DDX1	-1.93264777047709	0.00148187079003037
COAD	DHX36	AVEN	2.35956709118857	0.00160405039787293
HNSC	DHX36	IRF7	2.93335806497612	0.00170075397613801
BLCA	DHX36	DDX3X	-1.72328745230917	0.00202178955078125
LUAD	DHX36	DDX21	1.56838494507642	0.00228472010151165
HNSC	DHX36	DDX3X	-1.28722926526269	0.00343420156059438
HNSC	DHX36	DHX58	-2.79063884938583	0.00441007382391945
PRAD	DHX36	DDX56	-1.04496621367793	0.00587204297463364
ESCA	DHX36	DDX56	-1.84653952923301	0.009765625
COAD	DHX36	LRRFIP1	-2.8031854546023	0.0189773440361023
LIHC	DHX36	DDX21	1.19694918109185	0.0257535927654766
KIRP	DHX36	DHX58	1.82861714807764	0.0341199110262096
CHOL	DHX36	DHX58	-1.33335090692313	0.0390625
LUAD	DHX36	MYD88	-1.04286104307782	1.01882840863729e-05
BRCA	DHX36	DDX3X	-1.01592592365291	1.02907748399223e-16
LUAD	DHX36	DDX41	-2.55632263400249	1.0542655358657e-09
BLCA	DHX36	LRRFIP1	-4.59539342882609	1.1444091796875e-05
LUAD	DHX36	DDX1	-1.61550836542382	1.45287170087739e-05
KIRC	DHX36	AVEN	-1.45729824434965	1.61870448444469e-11
PRAD	DHX36	IRF7	-3.73326045576777	1.90539887114352e-05
LUAD	DHX36	DDX56	-3.06892534373792	2.17106231815174e-10
BRCA	DHX36	DDX41	-1.56329228327531	2.28007454618077e-18
THCA	DHX36	AVEN	-1.98758765782557	2.38140285206299e-08
LUSC	DHX36	MYD88	-3.10779873790332	2.42825252900713e-09
KIRC	DHX36	DDX1	-4.01417090847751	2.90348670181982e-08
KIRC	DHX36	MYD88	-5.05395451657998	2.99023580948584e-11
LUAD	DHX36	LRRFIP1	-1.66565566228063	3.0833479853658e-10
STAD	DHX36	DDX56	-4.15289347349838	3.25962901115418e-08
KICH	DHX36	LRRFIP1	-4.90803358440174	3.27825546264648e-06
LIHC	DHX36	DHX58	-3.82032605970644	4.9711683760311e-06
KIRC	DHX36	DDX56	-1.0315475541928	5.81016338316469e-09
KICH	DHX36	MYD88	1.56597315230955	5.96046447753906e-08
LUSC	DHX36	DDX56	-6.82561791802898	6.01874081187647e-09
KIRP	DHX36	MYD88	-2.76276688036337	6.0301274061203e-05
LIHC	DHX36	MYD88	-2.86370504889043	6.56770792936966e-09
BRCA	DHX36	DDX56	-2.06996817001943	6.78765448018142e-18
KIRC	DHX36	LRRFIP1	-1.329451252688	8.67487085760784e-09
THCA	DHX36	DDX1	-2.14439797401062	9.38064110141239e-05
KIRC	DHX36	IRF7	-2.2785692607676	9.77412860442126e-12

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with DHX36

ATG12, PRKAB1, PARVA, ACP6, GSK3B, ILK, PANK2, RICTOR, SIRT7, CUL3, COPS5, CAND1, HINT1, FUBP1, S100A6, TAGLN2, PTGES3, SEPT7, HEBP1, IL7R, TARDBP, HECW2, rev, RPA1, RPA2, RPA3, WWOX, ASB12, LIN28A, IVNS1ABP, ZFP36, Mib1, EZH2, HNRNPA1, ZBTB38, BYSL, GATA1, RBMX, UNK, DDX5, RECQL5, NTRK1, IFI16, CCDC93, Max, Mbd2, Rpl35, Vps28, Cep85l, FGF8, FGF3, TRIM25, PCBP1, PYHIN1, EFTUD2, RIOK1, ESR2, HEXIM1, MEPCE, LARP7, RUNX1, DPF2, RECQL4, HABP4, SERBP1, MB21D1, MYC, RC3H1, RC3H2, PHB, DISC1, NR2C2, APEX1, SNRNP70, BIRC3, STAU1, NFX1, BRD7, ERCC6, CMTR1, PLEKHA4, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, DAZL, DDX3X, MEX3B, ZC3HAV1, ZC3H7A, LARP4B, MOV10, DUX4, CIT, ANLN, ECT2, KIF23, MTERF3, TBRG4, MKI67, FASN, LRRC59, ZNF263, MAFB, RBM39, UFL1, TP53, ATG10, ATG3, PAGE4, VPS33B, ABT1, H2AFJ, RPS3, HIST1H1C, HNRNPUL2, RPS13, NUPL2, RPS16, YBX2, PURG, H2AFB2, ZNF777, SRSF3, HNRNPU, SYNCRIP, RBMS2, RBM19, PRR3, PDGFB, FGFBP1, RPL15, MAGEB2, C1orf35, AKR7L, HNRNPC, SRSF6, RPL27A, PABPC5, LIN28B, DDX55, RPL17, RPL26L1, RBM3, FAM120A, SRSF5, RPS10, SRSF1, RPL13, ILF2, RPS24, KRR1, RPL23A, SRSF7, GSPT2, ZNF346, SURF6, RPSA, RPSAP58, NEIL1, APOBEC3D, RPS19, RPS6, HIST1H2AM, ZNF574, HIST1H2AE, RBM4B, RPL31, RPS2, RPL19, ZNF668, PAIP1, HIST1H1E, MRPS17, SLFN11, ESR1, EP300, FSCN1, AGO2, AGO1, CPEB1, DDX58, G3BP1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
DHX36	LUSC	chr3	154017707	154017707	G	A	Missense_Mutation	p.A490V	5
DHX36	STAD	chr3	154010429	154010429	C	T	Silent	p.T575T	4
DHX36	STAD	chr3	154002693	154002693	C	A	Missense_Mutation	p.M705I	4
DHX36	BLCA	chr3	154018909	154018909	G	C	Missense_Mutation		3
DHX36	PAAD	chr3	154002724	154002724	C	T	Missense_Mutation	p.R695Q	3
DHX36	READ	chr3	154033003	154033003	C	A	Missense_Mutation	p.K145N	3
DHX36	PAAD	chr3	154018839	154018839	T	A	Missense_Mutation	p.K432I	3
DHX36	BRCA	chr3	153995455	153995455	C	T	Missense_Mutation	p.V874I	3
DHX36	PAAD	chr3	154018849	154018849	T	C	Missense_Mutation	p.R429G	3
DHX36	BLCA	chr3	154010428	154010428	G	A	Missense_Mutation	p.H576Y	3
DHX36	PAAD	chr3	154032888	154032888	A	C	Missense_Mutation	p.L184V	3
DHX36	LGG	chr3	154024015	154024015	G	A	Missense_Mutation	p.R295C	3
DHX36	ESCA	chr3	154018442	154018442	C	T	Missense_Mutation	p.D468N	3
DHX36	LIHC	chr3	154010440	154010440	T	-	Frame_Shift_Del	p.I572fs	3
DHX36	UCS	chr3	154018782	154018782	C	T	Missense_Mutation	p.R451Q	3
DHX36	PAAD	chr3	154018452	154018452	C	T	Missense_Mutation	p.M464I	3
DHX36	UCS	chr3	154018402	154018402	T	G	Missense_Mutation	p.Y481S	3
DHX36	PAAD	chr3	153995419	153995419	G	A	Missense_Mutation	p.L886F	3
DHX36	COAD	chr3	153998375	153998375	T	-	Frame_Shift_Del	p.R854fs	2
DHX36	KIRC	chr3	154022915	154022915	T	A	Silent	p.T312T	2
DHX36	STAD	chr3	154042020	154042020	G	T	Silent		2
DHX36	UCEC	chr3	154007560	154007560	C	T	Missense_Mutation	p.D624N	2
DHX36	STAD	chr3	154002773	154002773	C	T	Missense_Mutation	p.A679T	2
DHX36	BLCA	chr3	154018909	154018909	G	C	Missense_Mutation	p.P409A	2
DHX36	LIHC	chr3	154021173	154021173	C	T	Missense_Mutation		2
DHX36	SKCM	chr3	154027597	154027597	T	G	Missense_Mutation	p.I220L	2
DHX36	LIHC	chr3	154033872	154033872	T	-	Frame_Shift_Del	p.K108fs	2
DHX36	STAD	chr3	154010429	154010429	C	T	Silent		2
DHX36	STAD	chr3	154022736	154022736	C	T	Missense_Mutation	p.V332I	2
DHX36	UCEC	chr3	154013122	154013122	A	C	Missense_Mutation	p.F519C	2
DHX36	BLCA	chr3	154002700	154002700	C	T	Missense_Mutation	p.G703E	2
DHX36	SKCM	chr3	154017629	154017629	G	A	Missense_Mutation	p.S516L	2
DHX36	HNSC	chr3	154022638	154022638	C	A	Missense_Mutation	p.L364F	2
DHX36	LIHC	chr3	153994638	153994638	A	-	Frame_Shift_Del	p.F913fs	2
DHX36	THCA	chr3	154033843	154033843	G	C	Missense_Mutation	p.A118G	2
DHX36	KIRP	chr3	154006708	154006708	C	T	Missense_Mutation	p.D660N	2
DHX36	STAD	chr3	154042020	154042020	G	T	Silent	p.I62I	2
DHX36	STAD	chr3	154010343	154010343	C	T	Missense_Mutation	p.G604E	2
DHX36	UCEC	chr3	154021159	154021159	C	G	Silent	p.P392	2
DHX36	LIHC	chr3	154010423	154010423	A	-	Frame_Shift_Del	p.D578fs	2
DHX36	HNSC	chr3	154022955	154022955	C	T	Missense_Mutation	p.R299Q	2
DHX36	UCEC	chr3	154022722	154022722	G	T	Silent	p.I336	2
DHX36	PAAD	chr3	154032888	154032888	A	C	Missense_Mutation		2
DHX36	CESC	chr3	154024010	154024010	G	T	Silent		2
DHX36	UCEC	chr3	154029441	154029441	G	A	Missense_Mutation	p.S209L	2
DHX36	HNSC	chr3	154013097	154013097	C	T	Silent	p.L527L	2
DHX36	STAD	chr3	154032978	154032978	T	-	Frame_Shift_Del	p.M154fs	2
DHX36	CESC	chr3	154006737	154006737	C	T	Missense_Mutation		2
DHX36	STAD	chr3	154002448	154002448	T	G	Missense_Mutation	p.K739T	2
DHX36	UCEC	chr3	154033949	154033949	C	T	Missense_Mutation	p.A83T	2
DHX36	PAAD	chr3	153995419	153995419	G	A	Missense_Mutation		2
DHX36	STAD	chr3	154022719	154022719	A	C	Missense_Mutation	p.H337Q	2
DHX36	UCEC	chr3	154041969	154041969	C	T	Silent	p.R79	2
DHX36	LUAD	chr3	154027503	154027503	C	T	Missense_Mutation	p.R251K	2
DHX36	LUAD	chr3	154042092	154042092	T	A	Silent	p.G38G	2
DHX36	PAAD	chr3	154002724	154002724	C	T	Missense_Mutation		2
DHX36	BLCA	chr3	154018863	154018863	T	C	Missense_Mutation	p.Q424R	2
DHX36	STAD	chr3	154011567	154011567	A	T	Missense_Mutation	p.I547K	2
DHX36	STAD	chr3	154024054	154024054	C	T	Missense_Mutation	p.E282K	2
DHX36	PAAD	chr3	154018839	154018839	T	A	Missense_Mutation		2
DHX36	BLCA	chr3	153998570	153998570	C	T	Missense_Mutation	p.E820K	2
DHX36	ESCA	chr3	154018442	154018442	C	T	Missense_Mutation		2
DHX36	HNSC	chr3	154018467	154018467	T	C	Silent	p.V459V	2
DHX36	PRAD	chr3	154032977	154032978	-	T	Frame_Shift_Ins	p.V154fs	2
DHX36	STAD	chr3	154032899	154032899	A	G	Missense_Mutation	p.L180S	2
DHX36	UCEC	chr3	153993987	153993987	T	G	Silent	p.P1000	2
DHX36	STAD	chr3	154002694	154002694	A	G	Missense_Mutation	p.M705T	2
DHX36	SKCM	chr3	154042090	154042090	C	T	Missense_Mutation	p.G39D	2
DHX36	PAAD	chr3	154018849	154018849	T	C	Missense_Mutation		2
DHX36	KIRC	chr3	154018911	154018911	A	T	Missense_Mutation	p.V408D	2
DHX36	STAD	chr3	154033048	154033048	A	G	Silent	p.T130T	2
DHX36	UCEC	chr3	153995424	153995424	T	C	Missense_Mutation	p.N884S	2
DHX36	STAD	chr3	153995437	153995437	C	T	Missense_Mutation	p.D880N	2
DHX36	COAD	chr3	154032852	154032852	G	A	Missense_Mutation	p.R196W	2
DHX36	SKCM	chr3	154042118	154042118	G	A	Missense_Mutation	p.H30Y	2
DHX36	SKCM	chr3	154007527	154007527	G	A	Missense_Mutation	p.P635S	2
DHX36	LIHC	chr3	154018423	154018423	A	-	Frame_Shift_Del	p.L474fs	2
DHX36	KIRC	chr3	154018456	154018456	T	A	Missense_Mutation	p.E463V	2
DHX36	STAD	chr3	154007584	154007584	T	G	Missense_Mutation	p.N616H	2
DHX36	UCEC	chr3	154002443	154002443	C	T	Missense_Mutation	p.A741T	2
DHX36	STAD	chr3	154007599	154007599	A	T	Missense_Mutation	p.C611S	2
DHX36	SKCM	chr3	154027598	154027598	T	C	Silent	p.L219L	2
DHX36	LIHC	chr3	154018898	154018898	T	-	Frame_Shift_Del	p.K412fs	2
DHX36	LIHC	chr3	154010423	154010423	A	-	Frame_Shift_Del	p.F577fs	1
DHX36	READ	chr3	154011585	154011585	G	A	Missense_Mutation	p.P527L	1
DHX36	STAD	chr3	154010357	154010358	TC	-	Frame_Shift_Del	p.599_600del	1
DHX36	COAD	chr3	153993961	153993961	C	T	Silent	p.X995X	1
DHX36	LUSC	chr3	154024045	154024045	C	A	Missense_Mutation	p.G285C	1
DHX36	SKCM	chr3	153998449	153998449	T	A	Missense_Mutation	p.K829M	1
DHX36	THCA	chr3	154001060	154001060	C	A	Missense_Mutation		1
DHX36	BLCA	chr3	154042035	154042035	C	T	Silent	p.L57L	1
DHX36	ESCA	chr3	154010366	154010366	G	T	Silent	p.A596A	1
DHX36	HNSC	chr3	154022739	154022739	T	A	Missense_Mutation	p.I331F	1
DHX36	BLCA	chr3	154002700	154002700	C	T	Missense_Mutation		1
DHX36	COAD	chr3	154001024	154001024	C	T	Missense_Mutation	p.E763K	1
DHX36	KIRC	chr3	153994678	153994678	T	C	Missense_Mutation	p.Y900C	1
DHX36	LIHC	chr3	154018908	154018908	G	-	Frame_Shift_Del	p.P409fs	1
DHX36	STAD	chr3	154006670	154006670	T	C	Silent	p.R672R	1
DHX36	COAD	chr3	154006723	154006723	G	A	Silent	p.L641L	1
DHX36	HNSC	chr3	154027464	154027464	G	T	Missense_Mutation		1
DHX36	LIHC	chr3	154042059	154042060	-	C	Frame_Shift_Ins	p.G49fs	1
DHX36	MESO	chr3	154024058	154024058	C	A	Missense_Mutation		1
DHX36	SKCM	chr3	153994657	153994657	G	A	Missense_Mutation	p.P907L	1
DHX36	ESCA	chr3	153995473	153995473	C	T	Missense_Mutation	p.A868T	1
DHX36	BLCA	chr3	154033931	154033931	C	T	Missense_Mutation		1
DHX36	COAD	chr3	154001025	154001025	G	A	Silent	p.Y762Y	1
DHX36	LIHC	chr3	154022928	154022928	A	-	Frame_Shift_Del	p.L308fs	1
DHX36	READ	chr3	154002755	154002755	C	A	Nonsense_Mutation	p.E671X	1
DHX36	STAD	chr3	154033826	154033826	A	G	Splice_Site	p.G123_splice	1
DHX36	BLCA	chr3	154033931	154033931	C	T	Missense_Mutation	p.E89K	1
DHX36	COAD	chr3	154033942	154033942	A	G	Missense_Mutation	p.V85A	1
DHX36	HNSC	chr3	154002767	154002767	C	T	Missense_Mutation		1
DHX36	MESO	chr3	154018868	154018868	G	C	Missense_Mutation	p.F422L	1
DHX36	SKCM	chr3	153998449	153998449	T	A	Missense_Mutation	p.K815M	1
DHX36	LIHC	chr3	154000998	154000998	A	-	Frame_Shift_Del	p.F785fs	1
DHX36	SKCM	chr3	153994658	153994658	G	A	Missense_Mutation	p.P907S	1
DHX36	UCEC	chr3	153993987	153993987	T	G	Silent	p.P1000P	1
DHX36	CESC	chr3	154018887	154018887	G	C	Missense_Mutation		1
DHX36	HNSC	chr3	154002694	154002694	A	T	Missense_Mutation		1
DHX36	BLCA	chr3	153994583	153994583	C	G	Missense_Mutation		1
DHX36	COAD	chr3	154002694	154002695	-	T	Frame_Shift_Ins	p.M705fs	1
DHX36	KIRP	chr3	154006708	154006708	C	T	Missense_Mutation		1
DHX36	LIHC	chr3	154022942	154022942	T	-	Frame_Shift_Del	p.K303fs	1
DHX36	SARC	chr3	154006744	154006744	G	T	Missense_Mutation		1
DHX36	STAD	chr3	154033826	154033826	A	G	Splice_Site	.	1
DHX36	STAD	chr3	154013119	154013119	A	T	Nonsense_Mutation	p.L520*	1
DHX36	DLBC	chr3	154002774	154002774	G	A	Silent	p.N678N	1
DHX36	HNSC	chr3	154022739	154022739	T	A	Missense_Mutation		1
DHX36	LIHC	chr3	154032979	154032979	T	A	Missense_Mutation	p.K153N	1
DHX36	SKCM	chr3	153994658	153994658	G	A	Missense_Mutation	p.P893S	1
DHX36	HNSC	chr3	153994063	153994063	C	T	Missense_Mutation	p.R975K	1
DHX36	LIHC	chr3	154010435	154010435	T	-	Frame_Shift_Del	p.K573fs	1
DHX36	SKCM	chr3	154007607	154007607	G	A	Missense_Mutation	p.P608L	1
DHX36	UCEC	chr3	153998407	153998407	A	G	Missense_Mutation	p.V843A	1
DHX36	HNSC	chr3	154022638	154022638	C	A	Missense_Mutation		1
DHX36	BLCA	chr3	154032879	154032879	C	G	Missense_Mutation		1
DHX36	COAD	chr3	154010469	154010469	T	C	Missense_Mutation	p.D548G	1
DHX36	LGG	chr3	154032922	154032922	T	C	Silent	p.Q172Q	1
DHX36	LUAD	chr3	154011603	154011603	T	C	Splice_Site		1
DHX36	SARC	chr3	153995410	153995410	G	A	Missense_Mutation		1
DHX36	SKCM	chr3	154013111	154013111	G	A	Missense_Mutation	p.P523S	1
DHX36	STAD	chr3	154042185	154042185	C	A	Missense_Mutation	p.Q7H	1
DHX36	BLCA	chr3	154032879	154032879	C	G	Missense_Mutation	p.D187H	1
DHX36	ESCA	chr3	153993988	153993988	G	T	Missense_Mutation	p.P1000Q	1
DHX36	HNSC	chr3	154022616	154022616	C	G	Missense_Mutation		1
DHX36	LIHC	chr3	153998561	153998561	T	C	Missense_Mutation	p.I823V	1
DHX36	PAAD	chr3	154018452	154018452	C	T	Missense_Mutation		1
DHX36	LIHC	chr3	154011585	154011585	G	-	Frame_Shift_Del	p.P542fs	1
DHX36	PRAD	chr3	154032977	154032978	-	T	Frame_Shift_Ins	p.M154fs	1
DHX36	SKCM	chr3	154007593	154007593	G	A	Missense_Mutation	p.H613Y	1
DHX36	UCEC	chr3	154042019	154042019	C	G	Missense_Mutation	p.G63R	1
DHX36	HNSC	chr3	154018467	154018467	T	C	Silent		1
DHX36	BLCA	chr3	154018863	154018863	T	C	Missense_Mutation		1
DHX36	COAD	chr3	154013085	154013085	A	G	Silent	p.V517V	1
DHX36	LUAD	chr3	154042124	154042124	C	T	Missense_Mutation	p.G28R	1
DHX36	SARC	chr3	154029448	154029448	G	T	Missense_Mutation		1
DHX36	SKCM	chr3	154013110	154013110	G	A	Missense_Mutation	p.P523L	1
DHX36	STAD	chr3	154010350	154010350	G	A	Nonsense_Mutation	p.R602*	1
DHX36	BLCA	chr3	154027551	154027551	C	T	Missense_Mutation	p.G235D	1
DHX36	HNSC	chr3	153994063	153994063	C	T	Missense_Mutation		1
DHX36	LIHC	chr3	154022720	154022720	T	C	Missense_Mutation	p.H337R	1
DHX36	HNSC	chr3	154002767	154002767	C	T	Missense_Mutation	p.D681N	1
DHX36	LIHC	chr3	154018859	154018859	C	-	Frame_Shift_Del	p.G425fs	1
DHX36	PRAD	chr3	154010465	154010465	G	A	Silent	p.V563V	1
DHX36	SKCM	chr3	154001041	154001041	C	T	Missense_Mutation	p.R771Q	1
DHX36	STAD	chr3	154042078	154042080	CCG	-	In_Frame_Del	p.43_43del	1
DHX36	UCEC	chr3	154021159	154021159	C	G	Silent	p.P392P	1
DHX36	CESC	chr3	154018864	154018864	G	A	Nonsense_Mutation		1
DHX36	HNSC	chr3	154013097	154013097	C	T	Silent		1
DHX36	BLCA	chr3	153998570	153998570	C	T	Missense_Mutation		1
DHX36	COAD	chr3	154018887	154018887	G	C	Missense_Mutation	p.S416C	1
DHX36	LGG	chr3	154041998	154041999	-	T	Frame_Shift_Ins	p.G70fs	1
DHX36	SARC	chr3	153995410	153995410	G	A	Missense_Mutation	p.H889Y	1
DHX36	SKCM	chr3	153995469	153995469	A	G	Missense_Mutation	p.V869A	1
DHX36	STAD	chr3	154002398	154002398	G	A	Missense_Mutation	p.H756Y	1
DHX36	ESCA	chr3	154010366	154010366	G	T	Silent		1
DHX36	HNSC	chr3	154027540	154027540	G	A	Nonsense_Mutation	p.Q239*	1
DHX36	LIHC	chr3	154002370	154002370	A	T	Splice_Site		1
DHX36	KICH	chr3	154033067	154033067	T	A	Missense_Mutation		1
DHX36	LIHC	chr3	154018869	154018869	A	-	Frame_Shift_Del	p.F422fs	1
DHX36	PRAD	chr3	154002379	154002379	G	A	Missense_Mutation	p.A762V	1
DHX36	SKCM	chr3	153993991	153993991	G	C	Missense_Mutation	p.P999R	1
DHX36	UCEC	chr3	153994087	153994087	A	G	Missense_Mutation	p.V967A	1
DHX36	CESC	chr3	154032945	154032945	G	A	Nonsense_Mutation		1
DHX36	UCS	chr3	154018402	154018402	T	G	Missense_Mutation		1
DHX36	BLCA	chr3	153994026	153994026	G	T	Silent		1
DHX36	COAD	chr3	154024012	154024012	G	A	Missense_Mutation	p.L296F	1
DHX36	LGG	chr3	154024015	154024015	G	A	Missense_Mutation		1
DHX36	LUAD	chr3	154042080	154042080	G	A	Silent	p.G42G	1
DHX36	LUAD	chr3	154027551	154027551	C	-	Frame_Shift_Del	p.G235fs	1
DHX36	SKCM	chr3	154007607	154007607	G	A	Missense_Mutation	p.P594L	1
DHX36	SKCM	chr3	154002611	154002611	T	G	Missense_Mutation	p.I733L	1
DHX36	STAD	chr3	154010357	154010358	TC	-	Frame_Shift_Del	p.R599fs	1
DHX36	LIHC	chr3	154042052	154042052	G	A	Missense_Mutation	p.R52W	1
DHX36	KICH	chr3	154033067	154033067	T	A	Missense_Mutation	p.Y124F	1
DHX36	LIHC	chr3	154032917	154032917	T	-	Frame_Shift_Del	p.N174fs	1
DHX36	SKCM	chr3	154018391	154018391	C	T	Missense_Mutation	p.E485K	1
DHX36	CESC	chr3	154018864	154018864	G	A	Nonsense_Mutation	p.Q424*	1
DHX36	UCS	chr3	154018782	154018782	C	T	Missense_Mutation		1
DHX36	BLCA	chr3	154018422	154018422	C	A	Missense_Mutation		1
DHX36	COAD	chr3	154032839	154032839	A	G	Missense_Mutation	p.M200T	1
DHX36	LGG	chr3	154032922	154032922	T	C	Silent		1
DHX36	LUAD	chr3	153998377	153998377	T	C	Missense_Mutation	p.K853R	1
DHX36	LUSC	chr3	154001039	154001039	G	A	Missense_Mutation	p.R772C	1
DHX36	SKCM	chr3	154042099	154042099	G	A	Missense_Mutation	p.S36F	1
DHX36	STAD	chr3	153998375	153998376	-	T	Frame_Shift_Ins	p.R854fs	1
DHX36	BLCA	chr3	154022956	154022956	G	A	Splice_Site	p.R299W	1
DHX36	ESCA	chr3	153993988	153993988	G	T	Missense_Mutation		1
DHX36	HNSC	chr3	154027464	154027464	G	T	Missense_Mutation	p.P264Q	1
DHX36	LIHC	chr3	154002762	154002762	T	-	Frame_Shift_Del	p.K682fs	1
DHX36	PRAD	chr3	154042043	154042043	C	A	Missense_Mutation	p.G55W	1
DHX36	SKCM	chr3	154042100	154042100	A	G	Missense_Mutation	p.S36P	1
DHX36	ACC	chr3	153994065	153994065	G	T	Silent	p.S974S	1
DHX36	CESC	chr3	154006737	154006737	C	T	Missense_Mutation	p.G650E	1
DHX36	BLCA	chr3	154032967	154032967	G	C	Missense_Mutation		1
DHX36	LIHC	chr3	154002684	154002684	A	G	Silent		1
DHX36	LUAD	chr3	154011591	154011591	C	G	Missense_Mutation	p.R539T	1
DHX36	LUSC	chr3	154010470	154010470	C	T	Missense_Mutation	p.D562N	1
DHX36	TGCT	chr3	154033066	154033066	G	A	Silent		1
DHX36	BLCA	chr3	154032967	154032967	G	C	Missense_Mutation	p.I157M	1
DHX36	ESCA	chr3	154033872	154033872	T	A	Missense_Mutation	p.K108N	1
DHX36	HNSC	chr3	154002694	154002694	A	T	Missense_Mutation	p.M705K	1
DHX36	ACC	chr3	153994065	153994065	G	T	Silent	p.S960S	1
DHX36	CESC	chr3	154024010	154024010	G	T	Silent	p.L296	1
DHX36	LIHC	chr3	154006724	154006724	A	-	Frame_Shift_Del	p.F654fs	1
DHX36	READ	chr3	154006755	154006755	T	C	Splice_Site	.	1
DHX36	SKCM	chr3	154042037	154042037	G	A	Silent	p.L57L	1
DHX36	BLCA	chr3	154042035	154042035	C	T	Silent		1
DHX36	COAD	chr3	154042124	154042124	C	A	Missense_Mutation	p.G28W	1
DHX36	LIHC	chr3	153998561	153998561	T	C	Missense_Mutation		1
DHX36	SKCM	chr3	154033018	154033018	A	T	Silent	p.L140L	1
DHX36	THCA	chr3	154033843	154033843	G	C	Missense_Mutation		1
DHX36	BLCA	chr3	154042138	154042138	C	G	Missense_Mutation	p.G23A	1
DHX36	ESCA	chr3	153998393	153998393	G	T	Missense_Mutation	p.L848I	1
DHX36	HNSC	chr3	154022616	154022616	C	G	Missense_Mutation	p.E372Q	1

Copy number variation (CNV) of DHX36
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across DHX36
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
69783	Non-Cancer	61N	CLDN18	chr3	137743566	+	DHX36	chr3	154011601	-
69783	N/A	AX184358	DCAF13	chr8	104432692	+	DHX36	chr3	154037451	-
69783	N/A	AA251139	DHX36	chr3	154032708	+	DHX36	chr3	154031544	+
69783	N/A	DN916446	DHX36	chr3	154021151	+	DHX36	chr3	154012461	+
96629	N/A	AW022050	DHX36	chr3	154018838	-	RNF121	chr11	71695824	-
69783	STAD	TCGA-CG-4301	FAT1	chr4	187560875	-	DHX36	chr3	154001060	-
69783	STAD	TCGA-CD-8531-01A	MIR29B1	chr7	130596869	-	DHX36	chr3	154033952	-
69783	N/A	DL059586	PPP1R16B	chr20	37539198	+	DHX36	chr3	153993457	+
69793	N/A	BI493012	PSPC1	chr13	20349499	-	DHX36	chr3	154018838	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	DHX36	0.00178258510695946	0.048
TGCT	DHX36	0.0044597445906426	0.12
LUAD	DHX36	0.00509350689717991	0.13
SARC	DHX36	0.00939801548304557	0.23
PAAD	DHX36	0.0130625099959731	0.3
KIRP	DHX36	9.18935257557635e-05	0.0026

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LGG	DHX36	0.00235365816664039	0.075
OV	DHX36	0.0132580675148859	0.41
ESCA	DHX36	0.00161888271590485	0.053
THYM	DHX36	0.0290731166125984	0.84
SARC	DHX36	0.0193599792276102	0.58

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source